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Articles 46771 - 46800 of 1825171
Full-Text Articles in Entire DC Network
Why Is It Always The Boys?: Evaluating Disciplinary Issues Within The Classroom, Brian P. Lynch
Why Is It Always The Boys?: Evaluating Disciplinary Issues Within The Classroom, Brian P. Lynch
West Chester University Graduate Theses, Dissertations, and Final Projects
This thesis explores the concept of discipline in the classroom and the overrepresentation of male students in disciplinary action. American public schools are nearly equally represented with male and female students, yet disciplinary action is taken far more frequently toward male students. Throughout the course of this paper, a history of disciplinary action in America is relayed. Psychological and social factors are acknowledged to explain the differences of actions in the classroom between male and female students.
To best impact students in the classroom and relieve the overrepresentation of male disciplinary issues, a community program should take place throughout the …
What We're Not Allowed To Teach: The Epistemic Suppression Of The Null Curriculum In American Formal Education, Monica Zheng
What We're Not Allowed To Teach: The Epistemic Suppression Of The Null Curriculum In American Formal Education, Monica Zheng
West Chester University Graduate Theses, Dissertations, and Final Projects
This thesis explores the history and impact of the null curriculum, which Eisner (1994) defines as "what schools do not teach" (p. 97). The null curriculum often contradicts the messages that the dominant white-supremacist patriarchy has indoctrinated into the explicit curriculum into the curriculum that American formal education uses, especially with the advent of high-stakes standardized testing. In order to overthrow this capitalist system, teachers must feel safe teaching the null curriculum. This thesis makes the case that internal reform of the American formal education system is not enough to create this liberated learning experience, and an external, full …
Donor Impact Report 2025-2026, University Of San Diego School Of Law
Donor Impact Report 2025-2026, University Of San Diego School Of Law
Donor Impact Report
No abstract provided.
Virtue Development A Christian Perspective On Character Formation In Community, Rebecca Konyndyk Deyoung
Virtue Development A Christian Perspective On Character Formation In Community, Rebecca Konyndyk Deyoung
University Faculty Publications and Creative Works
How do we become people of good character? Our default answer might include individual practices or a new program of self-discipline. This white paper will challenge that answer by introducing a more complex framework. For the Christian, spiritual maturity (“being sanctified through and through,” 1 Thess. 5:23) requires the development of virtue, empowered by the Holy Spirit, for life within the kingdom community.
- We are created for love and belonging in a life of communion with the Trinitarian God and with our neighbors. The goal of cultivating virtue is to be fitted for good community and to function well within …
The Efficacy Of International Conflict Feminism In Postconflict Peacebuilding: Learning From The Lived Experiences Of Liberian Women Through A Decolonial Lens, Kristen N. Mcnutt
The Efficacy Of International Conflict Feminism In Postconflict Peacebuilding: Learning From The Lived Experiences Of Liberian Women Through A Decolonial Lens, Kristen N. Mcnutt
Antioch University Dissertations & Theses
Focusing on Liberia, this study investigates the efficacy of governance feminism (GF) and international conflict feminism (ICF) in postconflict liberal peacebuilding, specifically analyzing United Nations Security Council Resolution 1325 and the Women, Peace, and Security (WPS) agenda to reveal critical gaps between policy narratives and the lived realities of Liberian women. Grounded in decolonial feminism and the coloniality of gender and peace frameworks, the research integrates ideographic narrative analysis of UN Women and Liberian government policy reports, a day-in-the-life study with 13 Liberian women, and surveys and interviews with multilevel actors across international organizations, government, and grassroots organizations, guided by …
The Caregiving Experience: Comparing Stress And Quality Of Life Among Caregivers Of Children With And Without Autism Spectrum Disorder, Mona Khayal
Antioch University Dissertations & Theses
This comparative cross-sectional study investigated caregiving burden, quality of life, and anxiety among primary caregivers of children with autism spectrum disorder compared to caregivers of typically developing children. Using Bronfenbrenner’s Ecological Systems Theory, 66 caregivers (31 autism, 35 comparison) of children aged 6-18 completed the Zarit Burden Interview-12, WHO Quality of Life-BREF, and GAD-7. According to the results, autism caregivers reported substantially higher burden (M = 31.26 vs. 13.23, d = 2.42) and anxiety (M = 9.13 vs. 4.63, d = 1.04), with 90% exceeding clinical burden thresholds compared to 26% of comparison caregivers. Quality of life was lower across …
Generation Z: Black Male Constructions Of Masculinity And Provider Roles In Heterosexual Marriages, Bentley Stafford Hylton
Generation Z: Black Male Constructions Of Masculinity And Provider Roles In Heterosexual Marriages, Bentley Stafford Hylton
Antioch University Dissertations & Theses
This study explores how expectations associated with the male provider role identity impact the psychological well-being of Black American Generation Z (“Gen Z”) men. Using a qualitative design, approximately 20 participants were surveyed to examine how efforts to meet provider role expectations influence well-being, as well as how Gen Z Black men construct and define masculinity within contemporary sociocultural contexts. While prior research has examined Black masculinity, limited attention has been given to its intersection with provider role expectations, particularly among emerging adults. Historically, messages about masculinity and marital roles have been transmitted through community institutions, leadership, and cultural narratives; …
More Than Surviving: Brazilian Immigrants' Stories Of Growth And Wellbeing In The United States, Virginia Veronica Lemos
More Than Surviving: Brazilian Immigrants' Stories Of Growth And Wellbeing In The United States, Virginia Veronica Lemos
Antioch University Dissertations & Theses
Immigration in the United States is often conceptualized within clinical psychology through deficit-oriented frameworks that emphasize risk, trauma, and psychological distress. While this work is essential for documenting vulnerability and inequity, it offers limited guidance for understanding how immigrants sustain wellbeing and meaning amid ongoing sociopolitical and institutional constraints. Brazilian immigrants represent a large and growing population in the US whose experiences remain comparatively understudied, particularly from strengths-based and interpretive perspectives. To address this gap, this qualitative study explores how Brazilian immigrants make sense of immigration and wellbeing through the narratives they construct about their lives in the US. Grounded …
Culturally Grounded Interventions Within Natural Settings: An Investigation Of How Cultural Learning Within Place Can Lead To The Enhancement Of Well-Being, Dean Masaji Tanikawa
Culturally Grounded Interventions Within Natural Settings: An Investigation Of How Cultural Learning Within Place Can Lead To The Enhancement Of Well-Being, Dean Masaji Tanikawa
Antioch University Dissertations & Theses
This study examines the impact of Culturally Grounded Interventions within Natural Settings on participants’ health and well-being, using Wilson’s (2008) Indigenous Paradigm to counter the limitations of past positivist approaches used by non-Native researchers. Culturally Grounded Interventions incorporating traditional Hawaiian practices such as mahi ‘āina (farming), koa ‘āina (reforestation), and Lā’au Lapa’au (herbal therapy) were performed at Ho’oulu ‘Āina, a nature preserve in Kalihi Valley, Hawaiʻi, Ho’oulu ‘Āina, sits on a wahi pana (sacred site), and serves the Kalihi community with cultural education and healing. The study highlights, how relationships, including connections to land (‘āina), …
A Delphi Study Of Ethical Best Practices For Psychedelic Assisted Therapy, Alyssa K. Griskiewicz
A Delphi Study Of Ethical Best Practices For Psychedelic Assisted Therapy, Alyssa K. Griskiewicz
Antioch University Dissertations & Theses
The purpose of this Delphi study was to establish areas of ethical consensus regarding psychedelic-assisted therapy (PAT) from the perspectives of an expert panel of practitioners, with attention to issues of equity and access. Participants (N = 29) include individuals with two or more years of experience in one or more of the following domains of psychedelic expertise: clinical/professional practice, scholarly/research contributions, or guided community/ceremonial facilitation. In Round 1, qualitative data were collected through open-ended questions and analyzed using thematic analysis to generate Delphi statements. In Round 2, panelists (N = 24) rated these statements using a Likert-type scale to …
"Why Don't I Talk To A Therapist?": Motivations And Reflections Of Female-Identifying Chinese Immigrants Seeking Psychotherapy For Depression, Qiuyi Wei
Antioch University Dissertations & Theses
This phenomenological study explored the lived experiences of Chinese immigrants and temporary residents struggling with depressive symptoms and their process of seeking and accepting psychotherapy support. The study aimed to describe the factors that motivated participants to enter therapy for depression while also addressing their internal concerns about treatment. Nine female-identified Chinese immigrant adults with such experiences were recruited. Participants’ perceptions of their depressive symptoms and the factors contributing to their decision to seek professional therapy were explored through in-depth, semi-structured qualitative interviews conducted in Mandarin. The interview transcripts were analyzed in Mandarin using interpretative phenomenological analysis, through which four …
Youth And Caregiver Expectations In Pediatric Concussion Recovery And Persisting Symptoms, Molly A. O'Reilly
Youth And Caregiver Expectations In Pediatric Concussion Recovery And Persisting Symptoms, Molly A. O'Reilly
Antioch University Dissertations & Theses
Concussions present complex diagnostic and treatment challenges, particularly for pediatric patients who may experience persisting symptoms. Psychological mechanisms, including patient expectations and beliefs about recovery and symptoms, play a critical role in shaping outcomes. However, there is limited research exploring these factors in pediatric populations, particularly using qualitative approaches. This study sought to address this gap by employing a qualitative phenomenological design with interpretive phenomenological analysis to examine the recovery expectations of pediatric patients with persisting symptoms following concussion, as well as caregivers’ perspectives. Using the nocebo effect as a conceptual framework, eight pediatric patients and their caregivers participated in …
Improving Parental Self-Efficacy In An Integrated Primary Care Setting, Leo Parini
Improving Parental Self-Efficacy In An Integrated Primary Care Setting, Leo Parini
Antioch University Dissertations & Theses
A pediatric mental health crisis in the United States has strained integrated primary care, leaving providers with high volumes of requests for psychotherapy. Low parental self-efficacy (PSE)—reduced caregiver confidence in supporting children's emotional and behavioral needs—may contribute to this demand. This study examined whether a brief, 4-week parent training curriculum informed by Supportive Parenting for Anxious Childhood Emotions (SPACE), targeting child anxiety and obsessive-compulsive disorder (OCD) and delivered by a clinical psychologist within an integrated primary care setting, would increase PSE. Using secondary, de-identified data, PSE was measured before and after the course with the Brief Parental Self-Efficacy Scale; 19 …
External Impacts On Internal Accounting, Maggie E. Boswell
External Impacts On Internal Accounting, Maggie E. Boswell
Honors Theses
This thesis examines how external economic, legal, political, and consumer pressures can affect internal operations, accounting, and audit risk, using PepsiCo, Inc. as a case study. The analysis draws on PepsiCo’s annual reports and Form 10-K, company disclosures, government materials, and business and news sources. Attention is given to the Make America Healthy Again initiative, changing health expectations, food regulation, tariffs, and sustainability concerns. The analysis finds that these pressures could increase research and development, production, inventory, legal, and supply-chain costs while also creating opportunities for PepsiCo to expand healthier products and sustainable practices. These operational changes may also increase …
Between Brushstroke And Cut: Editing Leon Golub's Persona In Kartemquin's Golub (1988), Frauke Thielecke
Between Brushstroke And Cut: Editing Leon Golub's Persona In Kartemquin's Golub (1988), Frauke Thielecke
Mendel Sato Research Award Projects
The documentary collective Kartemquin Films was founded in 1966 in Chicago and dedicated itself to bringing critical social issues onto the big screen. Early movies such as Now We Live on Clifton (1974), which dealt with inequality and displacement in Chicago neighborhoods, The Chicago Maternity Center Story (1976), calling out the forced closure of an important women's healthcare unit, and The Last Pullman Car (1983), which followed the conflict between labor unions and corporations at the Pullman railroad car factory, show Kartemquin's commitment to portraying pressing issues. Their movies often focus on a single protagonist and follow them over sometimes …
Narcos Of The Caribbean: Addressing Transshipment Drug Trafficking Through Caribbean Ports, Manuel Muñoz-Repiso
Narcos Of The Caribbean: Addressing Transshipment Drug Trafficking Through Caribbean Ports, Manuel Muñoz-Repiso
FIU Law Review
Drug trafficking from source countries in South and Central America to other parts of the world is of growing concern as drug use increases globally. Driven by the region’s geographic proximity to source countries in South and Central America and weak antitrafficking infrastructure, drug traffickers have increasingly used routes through Caribbean ports to access target consumer nations. The use of Caribbean ports for transshipment trafficking has led to record homicide levels, corruption, and democratic backsliding. In response, Caribbean nations, other Western democracies, and international organizations have created numerous cooperative organizations and programs to reduce the number of drugs trafficked through …
In Its Right Mind - Governance Of Social Superintelligence, David Filippi, Bill Tomlinson, Andrew W. Torrance
In Its Right Mind - Governance Of Social Superintelligence, David Filippi, Bill Tomlinson, Andrew W. Torrance
FIU Law Review
This Comment argues that a broad presumption of public access to court documents is essential to preserving the legitimacy and constitutional values of the American legal system. Although the principle of public access is rooted in common law and constitutional tradition, individual states differ in how they approach transparency in the context of court documents. These jurisdictional inconsistencies continue to gain significance, as the digital age has completely transformed the way people consume information. The increasing digitization of court records has heightened the need for consistent and constitutionally grounded standards that preserve transparency while adequately protecting legitimate privacy interests. Florida’s …
Fear, Uncertainty, And The Chilling Effect: A Case Study Of Organizational Racialized Omission, Annie Jones
Fear, Uncertainty, And The Chilling Effect: A Case Study Of Organizational Racialized Omission, Annie Jones
Graduate Studies Theses and Dissertations 2026
Florida passed House Bill 7 in 2022 and Senate Bill 266 in 2023, both policies that restrict how race and racism are discussed and taught in the public higher education setting. Although scholars of race and racism contend that colorblind ideology drives the “new racism,” the U.S. is experiencing a resurgence in similar curriculum bans explicitly based on topics related to race and racism. With these trends has emerged a need to understand how explicitly racialized policies fit within the “new racism” framework. Using Victor Ray’s Theory of Racialized Organizations, this study analyzes how colorblind ideology and racialized threat are …
The Need To Prioritize Educating Special Educators On Augmentative And Alternative Communication Systems, Natalie Owens
The Need To Prioritize Educating Special Educators On Augmentative And Alternative Communication Systems, Natalie Owens
Graduate Research Papers
As alternative and augmentative communication (AAC) devices continue to be present in classrooms, it is vital for special educators to have a grasp of the potential systems they could interact with. Existing literature has indicated three main themes among special educators and their relation to AAC systems: a lack of preservice training, poor in-field experiences relating to collaboration and deficiencies in educational resources, and little understanding of evidence-based interventions and their implementations. It will be shown that through the continued absence of AAC systems in preservice training, special educators’ knowledge and skill set will help future students suffer. This synthesis …
Navigating Retail Automation: The Impact Of Perceived Autonomy Support On Frontline Employee Digital Adaptive Performance, Xun (Catherine) Sun, Ishtehar Sharif Swazan, Song-Yi Youn
Navigating Retail Automation: The Impact Of Perceived Autonomy Support On Frontline Employee Digital Adaptive Performance, Xun (Catherine) Sun, Ishtehar Sharif Swazan, Song-Yi Youn
Faculty Publications - Family and Consumer Sciences
As automated technologies become increasingly embedded in retail operations, understanding the antecedents of enhancing frontline employees’ digital adaptive performance has become critical. The study examines (a) how frontline employees’ perceptions of autonomy support from supervisors enhance their motivations in enhancing digital adaptive performance in retail automation contexts, and (b) how technology anxiety moderates the influence of perceived autonomy support from supervisors on psychological motivation. Survey data from U.S. frontline retail employees (n = 305) were analyzed using PLS-SEM. The findings highlight the significant role of perceived autonomy support from supervisors in positively associating with all employees’ three basic psychological …
Lessons Learned From Clinical Trials Of Thymic Stromal Lymphopoietin (Tslp) Inhibition, Jonathan Corren, Larry Borish, Christopher Brightling, Joseph K. Han, Emma Guttman-Yassky, Steven Ziegler, Jean Publicover, Jyotsna Gulati, Nestor Molfino, Christopher S. Ambrose, Jean-Pierre Llanos, Lang Chen, Jane R. Parnes, Joseph Spahn, Andrew Lindsley
Lessons Learned From Clinical Trials Of Thymic Stromal Lymphopoietin (Tslp) Inhibition, Jonathan Corren, Larry Borish, Christopher Brightling, Joseph K. Han, Emma Guttman-Yassky, Steven Ziegler, Jean Publicover, Jyotsna Gulati, Nestor Molfino, Christopher S. Ambrose, Jean-Pierre Llanos, Lang Chen, Jane R. Parnes, Joseph Spahn, Andrew Lindsley
Department of Otolaryngology (ENT) Faculty Publications
Type 2 (T2) immune–mediated epithelial-driven diseases are characterized by dysregulated immune responses at epithelial barrier surfaces. A key mediator of these diseases is thymic stromal lymphopoietin (TSLP), an epithelial cytokine that acts as a regulator of both T2 and non-T2 inflammation. TSLP activates dendritic cells and other immune cells, promoting the release of proinflammatory cytokines, including IL-4, IL-5, and IL-13. Given its central role in initiating and amplifying T2 inflammation, TSLP has emerged as a promising therapeutic target in multiple epithelial-driven inflammatory diseases. Tezepelumab is a human monoclonal antibody that selectively blocks TSLP from interacting with its receptor complex, thereby …
Absolute Quantification And Identification Of Rna From Rna-Lipid Nanoparticles Using High Resolution Mass Spectrometry, Jason C. Funderburk, Yasir A. Alshehry, Matthew S. Halquist Phd, Sandro R.P. Da Rocha Phd
Absolute Quantification And Identification Of Rna From Rna-Lipid Nanoparticles Using High Resolution Mass Spectrometry, Jason C. Funderburk, Yasir A. Alshehry, Matthew S. Halquist Phd, Sandro R.P. Da Rocha Phd
Graduate Research Posters
Background
RNA therapeutics are a rising drug category with potential use for a range of conditions encompassing infectious diseases to therapies for cancer, diseases, and genetic disorders. RNA-lipid nanoparticles (RNA-LNPs) are the prominent delivery method for these therapeutics approved products include mRNA vaccines and polyneuropathy treatments. The emergency use authorizations and orphan drug status of current RNA-LNP drugs has allowed approval without finalization of the regulatory analytical procedures for quality monitoring. The objective of the study was to develop an LC-MS assay to simultaneously measure identity and concentration of two therapeutically relevant intact RNA constructs extracted from RNA-LNPs to enhance …
Annual Security Report For Calendar Year 2025, Illinois State University Police Department
Annual Security Report For Calendar Year 2025, Illinois State University Police Department
Clery Act Annual Security Report
Illinois State University Police Department Annual Security Report
Department Of English Newsletter, Winter 2025-2026, Illinois State University, Department Of English
Department Of English Newsletter, Winter 2025-2026, Illinois State University, Department Of English
Department of English Newsletter
Newsletter of the Illinois State University Department of English
Are Skip Laminectomy And Oblique Corpectomy Effective Options To Treat Degenerative Cervical Myelopathy While Preserving Motion? Results Of A Scoping Review, Justin L Lomax, Ankit Mehta, Aditya Vedantam, Rory Goodwin, Nathan Evaniew, Mario Ganau, Chris J Neal, Rex A W Marco, Ryan Quisling, Jonathan Palmer, Adam T Archie, Keith L Jackson, John G Devine, Jefferson R Wilson, Uzondu F Agochukwu
Are Skip Laminectomy And Oblique Corpectomy Effective Options To Treat Degenerative Cervical Myelopathy While Preserving Motion? Results Of A Scoping Review, Justin L Lomax, Ankit Mehta, Aditya Vedantam, Rory Goodwin, Nathan Evaniew, Mario Ganau, Chris J Neal, Rex A W Marco, Ryan Quisling, Jonathan Palmer, Adam T Archie, Keith L Jackson, John G Devine, Jefferson R Wilson, Uzondu F Agochukwu
Faculty, Staff and Student Publications
Study Design
Scoping Literature Review.
Objective
The aim of this literature review is to examine the results of both skip laminectomy and oblique corpectomy in the setting of degenerative cervical myelopathy (DCM).
Methods
A scoping review of the relevant literature examining the efficacy of cervical skip laminectomy and oblique corpectomy in patients with DCM was conducted using the Medline database. Our review strategy aimed at answering two research questions. #1: Do clinical outcomes differ between patients undergoing cervical laminoplasty vs skip laminectomy in the setting of myelopathy. #2: Which outcomes can oblique corpectomy provide, and how its related complication profile …
Parent And Family Guide, 2026-2027, Illinois State University, Dean Of Students Office, Parent And Family Services
Parent And Family Guide, 2026-2027, Illinois State University, Dean Of Students Office, Parent And Family Services
Parent and Family Guide
Campus guide prepared by the Illinois State University Dean of Students Office's Parent and Family Services Department
The Psychiatric Burden Of Hidradenitis Suppurativa: A Trinetx Analysis Of Sex-Specific Disparities In Mental Health And Medication Use, Emily Sheetz, Julia Feord, Collette Sholi, Parker Adams, Tamas Gal, Susan G. Kornstein, Arturo Saavedra
The Psychiatric Burden Of Hidradenitis Suppurativa: A Trinetx Analysis Of Sex-Specific Disparities In Mental Health And Medication Use, Emily Sheetz, Julia Feord, Collette Sholi, Parker Adams, Tamas Gal, Susan G. Kornstein, Arturo Saavedra
Department of Medicine Faculty Publications
Background:
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition associated with physical and psychological burden. Prior research has shown increased rates of depression and anxiety among individuals with HS; however, sex-based disparities in the prevalence of these mental health conditions in patients with HS remain underexplored.
Objective:
To evaluate sex-based differences in the prevalence of major depressive disorder (MDD), generalized anxiety disorder (GAD), and the prescribing of antidepressants and anxiolytics among patients with HS.
Methods:
Using the TriNetX database, we identified patients over the age of 18 who had a recorded diagnosis of HS. Propensity score matching based on …
Thyroid Storm At Sea: A Case Report Of Algae-Induced Thyrotoxicosis, Alynna Knaub, Amanda Cecchini, John Janousek, Laura Strojny, Jairo Noreña, Zachary Pawlikowski
Thyroid Storm At Sea: A Case Report Of Algae-Induced Thyrotoxicosis, Alynna Knaub, Amanda Cecchini, John Janousek, Laura Strojny, Jairo Noreña, Zachary Pawlikowski
Department of Medicine Faculty Publications
Iodine-induced thyrotoxicosis (IIT), also known as the Jod-Basedow phenomenon, is a rare yet recognized cause of hyperthyroidism. While iodinated contrast is the most frequent trigger, iodine-rich supplements such as seaweed products or supplements can also precipitate thyrotoxicosis, particularly in individuals with prior chronic iodine deficiency or preexisting thyroid nodular disease. We present a case of thyroid storm following short-term ingestion of Irish sea moss as part of a “crash diet.” A 37-year-old woman with type 1 diabetes mellitus, well controlled on subcutaneous insulin therapy, presented with nausea and vomiting after 6 days of following a restrictive diet consisting solely of …
Enhancing Mri Accessibility Through Community Engagement For Autistic Young Adults, Antonio F Pagán, Grace Gogola, Ashley Huang, Katherine A Loveland
Enhancing Mri Accessibility Through Community Engagement For Autistic Young Adults, Antonio F Pagán, Grace Gogola, Ashley Huang, Katherine A Loveland
Faculty, Staff and Student Publications
The present study, a community-engaged research initiative, was specifically designed to enhance MRI accessibility and optimize the overall experience for autistic Latino young adults. Crucially, we employed a Community-Based Participatory Research (CBPR) approach, ensuring that the voices and perspectives of the target community were central to every stage of inquiry. Insights were gathered from Community Scientist meetings and 18 autistic Latino young adults (ages 18-25) through focus groups with nine MRI-naïve individuals and individual interviews with a separate cohort of nine individuals who had prior MRI experience. Transcripts from these sessions underwent thematic analysis to identify key patterns related to …
Defining Clinically Meaningful Within-Patient Changes In Heart Failure: Jacc Heart Failure Position Statement, Amin Yehya, Rebecca Hahn, Barry Borlaug, Victoria Delgado, Andrew Ambrosy, Ross Arena, Nosheen Reza, Gregory Lewis, Natalie Tapaskar, Salvatore Carbone, Cynthia Chauhan, Mitchell A. Psotka, Norman Stockbridge, James Januzzi, Javed Butler, Jennifer Cowger, Biykem Bozkurt, John Spertus
Defining Clinically Meaningful Within-Patient Changes In Heart Failure: Jacc Heart Failure Position Statement, Amin Yehya, Rebecca Hahn, Barry Borlaug, Victoria Delgado, Andrew Ambrosy, Ross Arena, Nosheen Reza, Gregory Lewis, Natalie Tapaskar, Salvatore Carbone, Cynthia Chauhan, Mitchell A. Psotka, Norman Stockbridge, James Januzzi, Javed Butler, Jennifer Cowger, Biykem Bozkurt, John Spertus
Department of Medicine Faculty Publications
Heart failure (HF) clinical trials increasingly rely on diverse endpoints beyond mortality, including hospitalizations, imaging, hemodynamic status, biomarkers, functional capacity, and patient-reported outcomes. Although statistically significant differences between treatment groups are commonly reported, interpreting whether these changes are clinically meaningful for individual patients remains challenging. This JACC: Heart Failure position statement proposes a pragmatic framework for defining clinically meaningful within-patient change across commonly used HF outcomes by integrating measurement variability, prognostic associations, and patient-anchored evidence where available. Relative and absolute risk reductions should both inform interpretation of clinical events, while imaging, hemodynamic, biomarker, and functional measures require changes exceeding measurement …