Digital Commons Network^™

Case Report: Prolonged Response To Cabozantinib And Pembrolizumab In Treatment-Refractory Metastatic Pancreatic Ductal Adenocarcinoma, Anna M. Reagan, Hannah G. Mcdonald, Jaewon Kang, Hoda Saghaeiannejad Esfahani, Caroline G. Wright, Charles J. Bailey, Carleton S. Ellis, Kaylyn R. Collette, Reema A. Patel, Mayte Murillo, Samantha F. Stokley, Michael J. Cavnar, Prakash Pandalai, Mautin T. Barry-Hundeyin, Jessica Moss, Joseph Kim

Markey Cancer Center Faculty Publications

Immunotherapy has yet to demonstrate durable efficacy in pancreatic ductal adenocarcinoma (PDAC) despite the fact that pancreatic cancer cells have higher levels of immune checkpoint expression than other cancer cell types in which immunotherapy efficacy has been well established. We observed effective cytotoxicity with the combination therapy of pembrolizumab (an anti-PD-1 monoclonal antibody, mAb) and cabozantinib (an anti-MET small molecule) in vivo. This served as the basis for an investigator-initiated phase II clinical trial (NCT05052723). The trial was open to patients with treatment-refractory metastatic PDAC with a single-arm treatment protocol of pembrolizumab and cabozantinib. Here, we report the case of …

Mental Health Needs Of Families Of Patients In Intensive Care Units And The Role Of Mobile Health: Survey Study, Anthony Faiola, Saira Soroya, Zhonglin Hao, Reinhold Munker

Markey Cancer Center Faculty Publications

Background: The experiences of patients with COVID-19 and their families manifested the most devastating effects of family separation since the 1918 Spanish influenza pandemic and, with it, a call for solutions to patient isolation and its effect on family mental health.

Objective: This study examined the recent experiences of families of critical care (intensive care unit; ICU) patients related to anxiety and depression (AD), satisfaction with clinician-family communication, and counseling from mental health and social services. This study explored correlations between these factors and family interest in mobile health (mHealth) designed to improve information flow and communication from patient bedside …

Eef2k Promotes Immune Evasion In Melanoma Via Cyclin D1–Mediated Stabilization Of Pd-L1, Yijie Ren, Darby J. Ballard, Anil Kumar, Andy F. Song, Mitiksha Gupta, Xiaofang Xiong, Xingcong Ren, Jugal Kishore Das, Jin-Ming Yang, Jianxun Song

Markey Cancer Center Faculty Publications

Eukaryotic elongation factor 2 kinase (eEF2K) is a stress-responsive regulator of protein synthesis implicated in melanoma progression, but its role in tumor immune evasion remains poorly defined. We investigated how eEF2K influences programmed death ligand 1 (PD-L1) expression through modulation of Cyclin D1. We analyzed gene expression and dependency datasets from The Cancer Genome Atlas and the Cancer Dependency Map. Protein–protein interactions were assessed by co-immunoprecipitation. Cyclin D1 was inhibited pharmacologically with palbociclib. Immune responses were evaluated in murine B16-OVA and human A2058 melanoma models using flow cytometry and immunohistochemistry after genetic or pharmacologic modulation of eEF2K and Cyclin D1. …

Improving Blood Pressure Control Through Lifestyle Modification In African Americans Adults With Uncontrolled Hypertension, Tasha Leonard

Doctor of Nursing Practice (DNP) Scholarly Projects

African American adults have the highest incidence of uncontrolled hypertension (HTN), leading to premature cardiovascular death in Texas and worldwide. In a South Texas cardiac clinic, over 90% of African American adults with HTN also have obesity, compared with 55% of their Caucasian counterparts. The most prevalent factor affecting this group is poor understanding of blood pressure management, which leads to nonadherence to dietary and exercise recommendations, medication regimens, and blood pressure monitoring. The objective was to determine whether lifestyle modification using a hypertensive bundle would improve blood pressure management among African American adults in the clinical setting. The initiative …

Landfalling Hurricanes : Impacts Of Urban Growth On Rainfall And Flooding And Advances In Ai-Based Forecasting, Ankur Kumar

Dissertations

Hurricanes remain among the most destructive natural hazards, producing widespread impacts through extreme rainfall, flooding, and damaging winds. Rapid urbanization in coastal regions further amplifies these risks by modifying land surface characteristics and increasing population, while accurately forecasting hurricane evolution remains a major challenge. This dissertation addresses these challenges through three interconnected research objectives focusing on urbanization-induced hurricane modification, hydrological response, and AI-based hurricane forecasting. The first objective investigates how incremental multi-decadal urban growth modifies hurricane rainfall distribution and rainband evolution during Hurricane Harvey (2017). Convection-permitting WRF simulations demonstrate that realistic urban growth alters boundary-layer structure, storm-relative inflow, convective organization, …

Thermodynamics Of Bubble-Through Liquid-Core Nuclear Thermal Rockets, Dakota John Santana

Dissertations

Liquid-Core Nuclear Thermal Rockets (LNTR) were originally investigated in the 1960s. Exploratory efforts have thus far been relegated to preliminary models that illustrate proof-of- concept or identify theoretical limits. Collectively they would report ranges for 𝐼𝑠𝑝 between 1000 −2000 𝑠 and thrust-to-weights between 0.5 −6. This work expands a model for the Bubbler class of LNTRs into an engineering model suitable for design exploration and system model integration. Bubblers use centrifugal force to trap molten fissile fuel while bubbling propellant radially inward to cool structural members and achieve temperatures >4500 𝐾. The Bubbler model detailed herein, dubbed Fornax, expands the …

Improving Patient Adherence To Telehealth Appointments By Implementing A Bundle Intervention, Steve Erimwioghae

Doctor of Nursing Practice (DNP) Scholarly Projects

Background: Missed appointments undermine the benefits of telepsychiatry. An outpatient psychiatric practice in Texas reported a baseline no-show rate of 30.4%, exceeding national average and disrupting continuity of care, clinic efficiency, and revenue.

Purpose: Implement and evaluate a telepsychiatry adherence bundle—tiered automated reminders, structured pre-visit check-ins, and patient education—to reduce the no-show rate among adults receiving outpatient telepsychiatry care.

Methods: A pre- and post-quality improvement project, guided by the Plan-Do-Study-Act (PDSA) framework, delivered the bundle to all scheduled adult patients over eight weeks. De-identified appointment and demographic data were analyzed in SPSS using descriptive statistics and the …

A Guideline To Address Barriers To Mental Health Treatment Experienced By Law Enforcement Officers, Jacqueline Estrella

Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Law enforcement officers are exposed to repeated trauma on the job that may negatively affect their mental health. Officers may avoid seeking mental health treatment due to police culture, stigma, and other barriers which may increase risks for suicide, absenteeism, and maladaptive coping.

Objectives: Develop an evidenced-based guideline to address barriers law enforcement officers face in seeking mental health treatment.

Methods: The National Quality Measures Clearinghouse (NQMC) Domain Framework was used to guide a literature review to identify best practices suitable for a guideline. Articles were graded for strength based on the John Hopkins Nursing Evidence Based Practice (JHNEBP) …

Diffusion Of Excitons In Thin Films Of Quantum Dots, Dustin Roberts

Dissertations

Quantum dots are heavily used in modern devices, such as consumer television screens, lasers, medical sensors, solar cells, and quantum computing. Their tunability and photo-stability make them candidates for a variety of applications which formerly required either dyes or significant amounts of band structure engineering. Despite all of the current and active applications, there is a gap in the current literature with regards to how energy is transported through thin films of quantum dots, and what methods may be used to control transport direction and range. The goal of this dissertation is to help fill those gaps, towards the end …

Moréteau On Law, Language & Heritage, Agustin Parise, Mariano Vitetta, Michel Séjean

All Scholarship

No abstract provided.

Erasing The Artist, Policing The City: Michael Stewart And New York’S War On Graffiti, Vladislav Kirilov

Anthós

The 1983 death of Michael Stewart, a young Black graffiti artist, exposes the violent logic at the center of New York City’s War on Graffiti. Under Mayor Ed Koch and the rise of broken windows policing, graffiti was framed as a racialized symbol of disorder used to justify intensified control of public space. Rather than becoming political in this moment, graffiti is understood here as an already politicized form of expression shaped by racial and spatial inequality. The article examines how Stewart’s killing made police violence visible, provoking responses from artists, activists, and graffiti writers while revealing the human costs …

Practicing Professionalism Framework: A Coherent Course Structure Aligned With Effective Practices For Physics Programs (Ep3) Guidelines, Martha-Elizabeth Baylor, Suzanne White Brahmia

Physics and Astronomy Faculty Work

Many physics educators seek to improve their courses but feel constrained by traditional post-secondary structures and norms. Instructors often perceive a false tension between fostering inclusive learning environments and maintaining the rigor central to the discipline. The Effective Practices for Physics Programs (EP3) Guide synthesizes decades of research-based recommendations for improving physics education. However, it offers limited guidance on how to integrate these diverse recommendations into a coherent, course-level approach—a responsibility that falls to individual instructors, whose graduate training prepared them primarily as researchers rather than as educators. This paper begins by motivating and introducing the Practicing Professionalism Framework (PPF), …

Numerical Analysis And Simulation Of Enhanced Performance In Nanowire Cds/Cdte Solar Cells: A Pathway To Greater Than 25% Efficient Cdte Solar Cell, Riasad Badhan

Theses and Dissertations--Electrical and Computer Engineering

This Thesis finds a pathway to a significantly high-efficient CdTe based solar cell by demonstrating and harvesting the advantages of a nano-structure configuration in CdTe based solar cells. Nanowire CdS window layer and the “control”, planar CdS window layer films were fabricated in the laboratory and compared for their optical transmission and other characteristics affecting the performance of the CdS-CdTe solar cell. Numerical simulations were performed for a comparative evaluation of the embedded nanowire CdS-CdTe solar cell device and the traditional planar CdS-CdTe solar cell device. Experimentally measured spectral transmission of nanowire CdS film was used in the simulation environment. …

Robotizing Complex Welding Processes Through Imitation Learning And Generative Models From Human Demonstration, Yue Cao

Theses and Dissertations--Electrical and Computer Engineering

Arc welding processes demand real-time adaptive control that current robotic systems cannot achieve autonomously. This dissertation develops a systematic framework to robotize complex welding by learning from human demonstration, integrating generative modeling, physics-informed reconstruction, and model-based imitation learning. First, human--robot collaboration systems are established for both Gas Tungsten Arc Welding (GTAW) and Double-Electrode Gas Metal Arc Welding, combining robotic teleoperation with virtual reality interfaces to capture high-quality operator demonstrations. Second, a physics-informed neural network framework reconstructs complete molten pool flow fields from high-speed imaging, enriching process understanding beyond direct sensor observation. Third, generative models, including a hybrid latent variational autoencoder …

Strain-Induced Nonvolatile Domain Switching And Tunable Elastic Modulus In Ba1-Xsrxtio3 Membrane By Phase-Field Simulation., Laveeza Ahmad

Material Science and Engineering Dissertations

Ferroelectrics underpin a broad spectrum of technological applications due to its switchable ferroelectric polarization and the associated electro-mechanical responses under electrical, optical, thermal, and mechanical stimuli. Recent advancement in membrane technology offers new opportunities to tune ferroelectric polarizations via mechanical strains at relatively large magnitude and scale. However, its influence on the tunability of mechanical responses of the membrane remains underexplored. Herein, we developed a phase-field model for free-standing Ba_1-xSr_xTiO₃ ferroelectric membranes with stress-free boundary conditions on top/bottom surfaces and achieved strain-induced nonvolatile ferroelectric domain switching in the membrane. It is discovered that a …

Challenges And Applications Of Fine-Grained Temporal Action Understanding: Modeling Temporal Granularity And Data Efficiency, Halil I. Helvaci

Theses and Dissertations--Electrical and Computer Engineering

Fine-grained Temporal Action Segmentation (TAS) has become a cornerstone of video understanding, offering dense frame-level predictions essential for clinical assessment, surgical skill evaluation, and human-computer interaction. While TAS methods have delivered strong results on coarse-grained benchmarks, two fundamental challenges persist: (1) global attention mechanisms dilute boundary information critical for subsecond precision, a phenomenon we term the temporal granularity bottleneck, and (2) dense frame-level annotation remains prohibitively expensive, with most datasets requiring exhaustive labeling of lengthy untrimmed videos. These challenges are particularly pronounced in medical domains, where sub-second primitives define clinical outcomes while expert annotation remains scarce. In this dissertation, we …

Design Of Energy-Efficient, Scalable, And Flexible Tensor Processing Architectures With Electro-Photonic Integrated Circuits, Oluwaseun Alo

Theses and Dissertations--Electrical and Computer Engineering

In recent years, artificial intelligence has achieved remarkable success across domains such as computer vision, natural language processing, and scientific computing. This progress has been driven largely by advances in deep learning, particularly deep neural networks (DNNs), including convolutional neural networks (CNNs) and transformer-based models. While these models deliver unprecedented accuracy, often surpassing human performance, their computational complexity continues to grow rapidly due to multibillion- and trillion-parameter designs. As model sizes and deployment scales expand, the demand for energy-efficient and high-throughput hardware accelerators has intensified. Conventional electronic platforms based on CPUs, GPUs, ASICs, and FPGAs are increasingly constrained by the …

Learning-Enabled Methods For Optimal, Constrained, And Fault-Tolerant Robot Motion Planning, Charles L. Clark

Theses and Dissertations--Electrical and Computer Engineering

Safe and efficient motion planning is a core requirement for robots operating in complex real-world environments, yet traditional model-based approaches struggle to simultaneously achieve computational efficiency, solution optimality, and the ability to handle complex constraints and potential hardware failures. This dissertation investigates how neural networks, as general purpose function approximators, can be leveraged in both traditional and novel ways to overcome these limitations and advance beyond what purely model-based methods can offer. Three distinct contributions are presented. First, a new motion planner is developed that uses ReLU neural networks to decompose the configuration space into linear cost regions, enabling existing …

Asthma Integrative Review: Effects Of Aerobic Exercise On Asthma Exacerbation, Abigail Williams, Dazya Crayton, Nicole Stasiak, Sabrina Stich

Master's Projects

Asthma is a chronic respiratory illness defined by airway inflammation and episodes of exacerbation. Pharmacological intervention remains the treatment of choice; however, there is growing evidence to support moderate intensity aerobic exercise as adjunct therapy to promote asthma control. The integrative review evaluates current evidence supporting the PICO question: In adults with mild to moderate asthma, what is the effect of prescribed aerobic exercise on reducing exacerbations? A systematic search of CINAHL, Health Source: Nursing, MEDLINE, and PubMed identified eligible studies. The inclusion criteria required peer-reviewed quantitative articles written in English and published within the past five years. In addition, …

Dead Trees & Etz Chaim: A Messianic Jewish Autoethnographic Reflective Poetry Chapbook, Mark Trager

Master's Projects

This capstone project, Dead Trees & Etz Chaim, is an autoethnographic reflective poetry chapbook that explores the author’s identity as a Messianic Jewish believer through the Jewish motif of the Tree of Life (Etz Chaim). Drawing on personal experience, biblical texts and theology, and archival research, the collection integrates poetry and prose to examine themes of faith, worthiness, suffering, redemption, and salvation.

Structured in five thematic chapters, the chapbook traces a progression from early spiritual questioning and formative experiences, including the author’s bar mitzvah, to deeper theological reflections on the nature of the Jewish Messiah. The work advances the claim …

App-Uh-Latch-Uh, Sarah B. Moore

Master's Projects

This capstone project focuses on my personal experiences with the Appalachian dialect. Using scholarship as the background of the writing, I composed a series of creative nonfiction scenes from my life to foreground what could be revealed for K-12 teachers, administrators, and anyone interested in linguistic justice or about the Appalachian dialect and education. Then, I created a guide for teachers, detailing ways to better respond to prejudice against dialect and to create a sense of linguistic justice within the classroom. Throughout the project, it became increasingly clear that, while a vast amount of research exists about dialects and English …

Philosophical System Of General T-Continuity As The Base Of Culture-Space Economics, Victor L. Tonn

Faculty and Staff - Articles & Papers

This paper presents a holistic philosophical system based on systric forms, operational transformors, and T-Continuity, aiming to establish cultural foundations for Type I and II Economies. Culture-space economics bridges Earth and space, initiating universal economics for the Great Space Era. The Comprehensive Universe (『SELF』) comprises three systems supporting mutual-central, micro-private, and macro-collective economies. Humanity’s spaceward journey advances T-Continuity, with human creativity—not just technology—as the primary driver, offering hope for cosmic peace through ideal cultural-spatial economies. This paper presents a holistic philosophical system based on systric forms, operational transformors, and T-Continuity, aiming to establish cultural foundations for Type I and II …

2026 Series A & Series B (Federally Taxable) : Official Statement, Second Program Bonds, Tennessee State School Bond Authority.

Higher Education Facilities Program Bonds

No abstract provided.

Impacts Of Spatial Intensity Policies On Jakarta Property Prices, Stevanus J. Manahampi, M. Halley Yudhistira

Jurnal Ekonomi dan Pembangunan Indonesia

This study examines the effects of floor area ratio (FAR) and building coverage ratio (BCR) on property prices in Jakarta. Using a hdonic price mdel with data from property listings and a geographical information system (GIS) analysis, it explores how these regulations influence values across regions and property types, accounting for access to amenities and infrastructure. Results show FAR lowers prices in dense areas like Central Jakarta but raises them in less developed regions like East Jakarta. BCR effects are mixed, positive where infrastructure is strong but negative where it is weak, underscoring the need for context-specific urban planning.

Hubungan Pertumbuhan Ekonomi Dengan Inflasi Di 90 Kabupaten-Kota Indonesia, Samsul Arifin, Hermanto Siregar, Lukytawati Anggraeni, Yeti Lis Purnamadewi

Jurnal Ekonomi dan Pembangunan Indonesia

This study aims to explain the relationship between economic growth and inflation in 90 Indonesian cities during the period 2018–2022 using the GMM estimator with Windmeijer - Sigmund robust standard errors. The author’s findings reveal that the two-way relationship between the two is that economic growth has a significant positif effect on inflation, while inflation has a negatif but insignificant effect. Through the results of this study, policymakers and stakeholders can consider priority objectives, namely achieving economic growth targets compared to inflation problems during the COVID-19 crisis and economic development during the future economic recovery.

Strafford County 2025 Annual Report Of The Commissioners, Treasurer, Other County Officers, And The Strafford County Delegation For The Year Ending December 31, 2025, Strafford County Representatives

Strafford County, NH Annual Reports

This is an annual report for 2025 containing vital statistics for Strafford County in the state of New Hampshire.

Msw Portfolio, Ryan Stadheim

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Spiritual Ecology For Entanglement: Reshaping Perceptions Through Spirituality, Education, And Enchantment, Hannah M. Bregman

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

A Third Way: An Unlikely Professional Portfolio, Sami C. Pack-Toner

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Age, Law, And Political Economy, Alexander Boni-Saenz

Articles

This Article examines the intersection of age, class, and the law. Its central claim is that age is an essential dimension for the analysis of law and political economy. There are two primary reasons why. First, age is embedded in a large body of legal rules that structure the labor market and address vulnerabilities associated with particular life stages. Child labor laws set minimum ages for entry into the workforce, while social welfare laws use age eligibility criteria to shape the material conditions for older adults. Second, age and its sibling concept, generation, indirectly shape economic and political relations by …