Digital Commons Network^™

Catalytic Synthesis Of Protoberberine Alkaloids And Their Evaluation As Selective Dopamine Receptor Ligands, Ashok Reddy Gudipally

Dissertations, Theses, and Capstone Projects

Dopamine regulates motor control, cognition, reward, motivation, and neuroendocrine signaling. Disruption of dopaminergic neurotransmission is closely linked to central nervous system disorders, including Parkinson’s disease, schizophrenia, addiction, and related neuropsychiatric conditions. Because these functions are mediated by multiple dopamine receptor subtypes with distinct roles in physiology and disease, the discovery of subtype-selective ligands remains an important goal in neuropharmacology. Within this context, protoberberine alkaloids, particularly tetrahydroprotoberberines (THPBs), are attractive molecular frameworks because they combine structural complexity with broad biological relevance, including measurable activity in CNS-related diseases. Prior work from our laboratory and others established (–)-stepholidine (1.60) as an important lead …

Cognitive-Affective And Somatic Depressive Symptom Domains Related To Psychological Mechanisms And Sociodemographic Factors, Danielle B. Hazeltine

Dissertations, Theses, and Capstone Projects

Major depressive disorder is prevalent, chronic, and heterogeneous, including cognitive- affective (e.g., maladaptive beliefs or thinking patterns and sad mood) and somatic (e.g., fatigue, appetite, or sleep changes) symptom domains. While depression domains have been long theorized, research examining psychological mechanisms underlying this distinction is limited. Preliminary research suggests cognitive-affective symptoms relate more strongly to cognitive mechanisms (cognitive bias, perseverative thought), somatic symptoms relate more strongly to behavioral mechanisms (behavioral inhibition/activation), and gender, race, and ethnicity moderate these relationships. This study examined whether cognitive-affective and somatic symptom domains differentially relate to cognitive and behavioral mechanisms, and whether these relationships are …

Bridging Data Gaps In Retinal Imaging: From Structural Domain Adaptation To Topology-Aware Synthesis, Gözde Merve Demirci

Dissertations, Theses, and Capstone Projects

Comprehensive visualization of the retina is essential for diagnosing and monitoring blinding diseases such as Diabetic Retinopathy and Retinopathy of Prematurity (ROP), where pathological changes often extend beyond a single field of view. Despite significant advances in automated retinal image analysis, clinical deployment remains limited by two fundamental data gaps: a structural learning gap, arising from scarce expert annotations and poor generalization across imaging domains, and a spatial coverage gap, caused by the difficulty of acquiring multi-view retinal images in fragile populations. Although these challenges are often addressed independently, this dissertation argues that they are tightly coupled: accurate, …

Alzheimer’S Disease And Related Dementias Risk Profiles And Health Literacy Among South Asian Seniors, Sandra A. Kennedy

Dissertations, Theses, and Capstone Projects

Alzheimer’s Disease and Related Dementias (ADRD) pose significant health challenges globally, with South Asian seniors in the United States facing elevated risks due to high rates of cardiovascular disease, diabetes, and limited health literacy. This study assessed dementia literacy and the prevalence of cardiovascular, psychosocial, and lifestyle risk factors among South Asian seniors in New York City, utilizing community-based participatory research (CBPR) principles in collaboration with India Home, a community-based organization. Fifty-six (N=56) South Asian seniors aged 55 and older (M = 69.05, SD = 6.36), primarily of Indian or Bangladeshi origin, participated in the study. Data collection involved a …

Distinguishing Between Complex Post-Traumatic Stress Disorder And Post-Traumatic Stress Disorder: The Role Of Childhood Maltreatment, Catherine Harris

Dissertations, Theses, and Capstone Projects

The current study examined whether court-substantiated childhood maltreatment may be associated with increased risk for Complex PTSD (CPTSD) and whether individuals with CPTSD and individuals with PTSD could be distinguished in terms of complex trauma exposure. Children with documented cases of abuse and neglect prior to age 11 were matched on age, race, sex, and approximate family socioeconomic status with children without documented histories of maltreatment (controls) and both groups were followed prospectively into adulthood. Participants (N = 1,196) were assessed using a DSM-III-R based structured interview of PTSD symptoms and other self-report measures of psychiatric symptoms at mean age …

The Cranial Nerves And Electrical Stimulation, Devin K. P. Adair

Dissertations, Theses, and Capstone Projects

Cranial nerves provide afferent pathways that enable bottom-up modulation of central autonomic and cognitive neural pathways. Because these pathways project to brainstem nuclei such as the nucleus tractus solitarius and engage neuromodulatory systems, including the locus coeruleus, electrical stimulation offers a mechanistically grounded approach to influencing brain function. This thesis tested whether active transcutaneous auricular vagus nerve stimulation (taVNS) produces physiological responses indicative of parasympathetic engagement, defined as decreases in heart rate, increases in heart rate variability, and decreases in respiration relative to a dose-matched earlobe control condition. Using cardiac and respiratory measures as physiological markers, taVNS at the tragus …

Authoritarianism, Hostility And Threat: An Analysis Of American Political Podcasts Surrounding The 2024 Presidential Election, Noah D. Cohen

Dissertations, Theses, and Capstone Projects

Political rhetoric surrounding key events has seen sharp increases in emotionally affective speech, intergroup sentiment, and rhetoric unbecoming of democratic societies in recent years. Similarly, semi-democratic and ideologically driven speech has become increasingly normalized within an era of political polarization and hardline beliefs in modern media. Within this economy of outrage, sensational and largely unmoderated media formats, particularly podcasts, have become a mainstay of political information and discourse. This raises an important question: how does rhetoric surrounding political events construct intergroup sentiment and authoritarian rhetoric within political media, particularly American political podcasts? Further, given political podcasts’ growing social influence in …

Shifting To Using Desmos Or Geogebra Graphing Calculators In High School Mathematics Classrooms, Nancy Lin

Dissertations, Theses, and Capstone Projects

Most high school math classrooms in Long Island use the Texas Instruments TI-84+ CE graphing calculator in the three Regents math courses. Texas Instruments holds approximately 80% of the market share of the international graphing calculator market. At a manufacturer's suggested retail price of $150 per TI-84+ CE, an inequitable situation exists for math learning, as underfunded schools and students from lower socioeconomic backgrounds cannot afford to purchase one for home use. Such students have less experience using the handheld graphing calculator when they take high-stakes math exams. Through case studies of four suburban school districts in New York that …

Vibe Diggers: The Sampling Of Brazilian Music In Hip-Hop, Romulo De Carvalho Moraes Barbosa

Dissertations, Theses, and Capstone Projects

This dissertation investigates the trend of musical borrowings of 1970s MPB (música popular brasileira) by contemporary American hip-hop producers, especially in terms of what they have called a “Brazilian vibe.” A lot has been said about sampling already from legal, sociological, and historical points of view, but less has been said about its aesthetic procedures, and even less about the wider implications of a tendency for using transnational sources. In the case of MPB, hip-hop artists seem to understand the music they sample through an often vague, intuitive representation, which fuses qualities of those recordings with an intersubjective mood, a …

Possibilities Of Being: Black Women's Storytelling As Archival Undoing, Dasharah Green

Dissertations, Theses, and Capstone Projects

This dissertation constructs a discursive genealogy of Black women’s storytelling, positioning its art and aesthetics as a form of colonial archival undoing. Each chapter explores how transmission and documentation can transform—and circumvent—traditional colonial archives. Beginning at the start of the twentieth-century to present, this project traces the discursive legacies of Zora Neale Hurston, Audre Lorde, Michelle Cliff, and Staceyann Chin, examining each writer as a site of becoming as they individually (and collectively) seek to articulate an expansive idea of a Black world that constitutes a broader understanding of Black freedom. They each share a common goal of creating a …

Potential Energy Landscape Formalism For Quantum Liquids, Yang Zhou

Dissertations, Theses, and Capstone Projects

Atomic delocalization due to nuclear quantum effects (NQE) remains poorly understood in low-temperature liquids near the glass state and during vitrification. Many liquids can be described accurately by treating their nuclei as classical particles, but this approximation fails for light elements such as He and H₂, small hydrogen-containing molecules such as water, and systems in which zero-point motion or isotope-substitution effects are important. Developing a general thermodynamic and statistical-mechanical description of such liquids has been challenging. This dissertation extends the potential energy landscape (PEL) formalism, originally developed for classical liquids and glasses, to liquids that obey quantum mechanics and exhibit …

Mapping The Water Quality Of Jamaica Bay, New York (1996-2024): Principal Component Analysis And K-Means Clustering, Sneha Srivastava

Dissertations, Theses, and Capstone Projects

Jamaica Bay, located along the southeastern coast of New York City, acts as a biodiverse estuary of wetlands, meadows, and salt marsh islands. The purpose of this study is to analyze the water quality conditions of the region over time, comparing locations around the bay to identify hyperlocal features that influence larger trends in the hydrological system. Ten variables were used as water quality indicators, including total Kjeldahl nitrogen, salinity, pH, Secchi disk depth, and total phosphorus, among others, across five stations in the bay, between 1994 and 2024. After data cleaning and standardization methods were applied, principal component analysis …

Optimizing Nanoparticle Quality And Function In Applied Research, Angela M. Fried

Dissertations, Theses, and Capstone Projects

Radiology tests are among the fastest-growing categories of diagnostic analysis, and the gold standard of radiology tests is MRI.  MRI can be more informative if a contrast agent is used, and the standard of care contrasting agents (CA) are gadolinium-based.  Gadolinium is a heavy metal, toxic, and contraindicated for renal-compromised patients and the critically ill.  We propose a nanogel (NG) vehicle for an alternative organic CA.  CNs like 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPOL) and its derivatives have a variety of medical and industrial uses.  These cyclic CNs are stable, synthetic radicals with distinctive EPR/ESR signals and are helpful for various experimental applications, from …

Analyzing Harmony In Bulgarian And Bulgarian-Influenced Choral Arrangements From The Radio To The Screen, Annie Beliveau

Dissertations, Theses, and Capstone Projects

This dissertation investigates developments in arrangements and compositions made for Bulgarian choirs between 1950 and 2025. Arrangements from Bulgaria’s communist period (1944-1989), when musical radio broadcasts were tailored to promote nationalist sentiment, eventually reached the ears of foreigners on the other side of the Iron Curtain via recordings and ensemble tours. These obrabotki (arrangements of folk tunes) became popular in the “world music” boom of the 1980s, and foreign composers soon began to create new compositions for Bulgarian choirs to sing on albums and in scores for film, television, and video games. Over time, the uses of Bulgarian choir in …

Panopticism And Pan-Oticism: Sound-Power From Foucault To Deleuze, Eric Dillenberger

Dissertations, Theses, and Capstone Projects

From Muzak to long range acoustic devices (LRADs), the contemporary proliferation of sonic technologies for governing moods, behaviors, and potentialities complicates the virtual absence of sound within Michel Foucault's primarily visual modality of disciplinary power in Discipline and Punish, exemplified by his central conceptual model of the panopticon. This thesis develops the corollary concept of pan-oticism to theorize the transformation of sound-power and its political function within administered sonic ecologies from Foucault's disciplinary societies to Gilles Deleuze's societies of control. Within the enclosed spaces constitutive of disciplinary societies, sound-power remains subordinated to Foucault's visual logic of panopticism, extending …

Rethinking Road Racing Standards: Comparing New York Road Runners Race Results To Running Industry Standards, Jennie Coughlin

Dissertations, Theses, and Capstone Projects

Running has undergone a third boom in participation since 2020, driven largely by people seeking fitness options that were outside and socially distanced during the COVID-19 pandemic. Social media has also allowed runners from groups that did not traditionally participate to find community. As the road racing population has expanded to include more people, some road racing industry standards have not kept up. This project assesses what the road racing community looks like and measures industry standards against the community of participants to see what changes in those standards would be needed to make them inclusive for all participants.

To …

The Role Of Temperament In Criminal Trajectories: Development, Stability, And Predictive Power Across The Life Course, Joshua A. Lang

Dissertations, Theses, and Capstone Projects

Temperament, an individual's largely innate tendency to experience and regulate responses to their environment, has long been studied but was only recently introduced as a primary predictor of criminal behavior (DeLisi & Vaughn, 2014). While prior criminological theories have incorporated temperament-related constructs, such as negative affect (Agnew, 1992; Moffitt, 1993) and self-control (Gottfredson & Hirschi, 1990), no other theory has explicitly positioned temperament as the central factor in offending. DeLisi and Vaughn’s temperament-based theory of antisocial behavior posits that individuals with low effortful control and high negative emotionality—features of a difficult temperament—are more likely to engage in criminal behavior. Despite …

Riluzole As A Dual-Targeted Radiosensitizer For Osteosarcoma: Targeting Tumor Cells And Angiogenic Vasculature To Enhance Single High-Dose Radiotherapy Efficacy, Pooja P. Rao

Dissertations, Theses, and Capstone Projects

Osteosarcoma (OS), the most common primary bone malignancy of children and young adults, is intrinsically radioresistant, and outcomes for patients with unresectable or metastatic disease have not improved in over four decades. Single-dose radiation therapy (SDRT) is a potent modality against radioresistant, highly vascularized sarcomas, but its application in OS is constrained by dose-dependent normal tissue toxicity. Radiosensitizers achieving tumor control at lower doses therefore offer a direct route to widening the therapeutic window. Critically, OS radioresistance is not tumor-cell-autonomous. It emerges from two coordinated compartments: aberrant DNA repair and antioxidant capacity intrinsic to the tumor cell, and a radioprotective, …

Self-Organized Criticality In Biased Activated Random Walk, Joshua Meisel

Dissertations, Theses, and Capstone Projects

We demonstrate many of the conjectured universality and self-organized criticality (SOC) properties of the interacting particle system Activated Random Walk (ARW) in the setting of one-dimensional biased walks, as formulated for instance in Levine and Silvestri’s 2024 survey. Namely, there exists the same limiting critical state for two finite ARW models, as well as for the infinite model as the density approaches its critical value from below. Many of the desired properties hold, including heavy-tailed avalanches, but spatial correlations decay exponentially fast, a deviation from the SOC paradigm. Nonetheless, the obtained decay rate vanishes with the bias. Since the critical …

Parenthood And Re-Appraisal Of Childhood Maltreatment, Gayathri Cheran

Dissertations, Theses, and Capstone Projects

Background: Child maltreatment is associated with poorer physical and mental health outcomes across the lifespan.  Individuals’ appraisals of childhood maltreatment have important implications for these outcomes.  Appraisal is shaped by biological, psychological, and social-cultural factors, each of which undergoes change in parenthood.  Parenthood may prompt re-appraisal of childhood maltreatment in that being a parent evokes one’s experience of being parented.

Hypotheses: (1) Re-appraisal will be more likely in parents than non-parents.  In parents, re-appraisal will be more likely among: (2) primiparous parents, (3) parents with offspring of the same sex, and (4) parents who experienced maltreatment older in childhood (at …

Architects Of Mrna Fate: Molecular And Cellular Control Of P-Body Organization In The Drosophilia Melanogaster Female Germline, Samantha Milano

Dissertations, Theses, and Capstone Projects

Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein condensates that regulate mRNA storage, translational repression, and decay. While the biochemical principles governing condensate assembly have been extensively studied in vitro, how P-body organization is established and dynamically regulated in vivo to control specific mRNA populations remains poorly understood. This dissertation investigated the molecular and cellular mechanisms that govern P-body architecture and function in the Drosophila melanogaster female germline. First, I identified the conserved LSm protein Trailer Hitch (Tral) as a central organizer of P-body architecture. Using quantitative confocal and super-resolution microscopy combined with chemical perturbations, I showed that Tral coordinates the …

Applications Of Entanglement In Quantum Information, Nada Ali

Dissertations, Theses, and Capstone Projects

Entanglement is the resource that most sharply distinguishes quantum information processing from its classical counterpart, and this thesis examines it from two complementary directions: how it can be detected and quantified, and how it, together with the broader machinery of quantum correlations, interference, and measurement, can be put to use. We first study two simple, measurable conditions that detect bipartite entanglement, and show that the extent to which either is violated yields a lower bound on the negativity of a state. The bound is established for two qubits, extended to systems of arbitrary finite dimension, and sharpened when partial knowledge …

Unraveling Hemispheric Specializations In The Mouse Auditory Cortex: From Diseased Model Comparisons To Development, Demetrios Neophytou

Dissertations, Theses, and Capstone Projects

Hemispheric specialization is a fundamental organizing principle of mature auditory cortical function, allowing the left and right Auditory Cortex (ACx) to perform complementary computations on complex sounds. This division of labor is conserved across species, and mice recapitulate key forms of auditory cortical lateralization, providing access to the synaptic and circuit mechanisms that generate it. Disrupted hemispheric organization is also associated with neurodevelopmental disorders characterized by severe communication impairments, including Rett Syndrome (RTT). Despite this, we know little about how lateralized auditory circuits are assembled during development or why they become differentially vulnerable to neurodevelopmental disruption. Here, using a mouse …

The Development And Piloting Of A Novel Client-Rated Trans And Gender Expansive Clinical Competence Scale For Mental Health Providers, Karen Abraham

Dissertations, Theses, and Capstone Projects

Transgender and gender expansive individuals (TGEI) are people who encompass a broad and comprehensive set of experiences of gender diverse individuals and identities that exist both within and beyond a binary framework. In the United States, the Williams Institute identified a proportion of 0.5% of American adults identifying as transgender (Herman et al., 2022). TGE samples report poorer physical and mental health than their cisgender counterparts across the lifespan (Rastogi et al., 2025; Reisner et al., 2015; Reisner, Poteat, et al., 2016). Health disparities of TGEI relative to their non-TGE counterparts can be seen in the prevalence of mood disorders …

Performing Hybridity: Solo Cello Works By Diasporic Korean Composers Isang Yun And Younghi Pagh-Paan, Sarah Song

Dissertations, Theses, and Capstone Projects

This dissertation follows my personal exploration of solo cello works by Korean diasporic composers Isang Yun and Younghi Pagh-Paan. While the study of postwar Korean music has long been discussed within an “East meets West” framework, my research aims to abandon such divisive binaries and explores the activity between two musical cultures during learning and performance. By engaging with a wide network of meaning (e.g., score-based, extra-musical knowledge, historical context), I track cumulative layers of discovery while considering a multitude influences from Korean and Austro-Germanic cultures as a second-generation Korean American. My methodology includes a reflective approach categorized in two …

Object (Im)Permanence: Toward A Hauntology Of The Violin, Pala Garcia

Dissertations, Theses, and Capstone Projects

Object (Im)permanence goes looking for the violin’s ontological uncertainties, its persistent historical specters, and its relation to things not fully present, no longer, or yet to come. Drawing on the history of the author’s own instrument as an inherited object, this study explores the violin’s strangest affordances: its capacity to hold a psychic charge, sustain absent presence, remotely activate somatic memory, and invite reciprocal relationality. Adapting the Derridean concept of “hauntology” as a framing for the violin’s spectral vitality, Object (Im)permanence imagines how a hauntology of the violin can account for its ontological uncertainties, logic of absent presence, and persistent …

Behind The Score: The Influence Of Neighborhood Policy Contexts On New York Regents Exam Performance Across New York City Public High Schools, Philip J. Kovacevic

Dissertations, Theses, and Capstone Projects

This study used a two-level hierarchical linear model (HLM) to test whether New York City neighborhood zoning and land-use characteristics independently predict school-level performance on the New York State Regents Examinations, after controlling for school demographic and organizational characteristics, and Regents mean scores, both drawn from the NYC DOE's Regents Exam Results file (NYC Public Schools InfoHub, 2024). Using NYC Primary Land Use Tax Lot Output (PLUTO) 2025 data, a Neighborhood Educational Quality (NEQ) index was built for each of the city’s 42 community districts by combining the commercial floor area ratio (CommFAR) and the proportion of lots zoned residential …

Cavity Optomechanics Via Mechanically Induced Coupling Of Optical Modes, Satyam S. Jha

Dissertations, Theses, and Capstone Projects

This thesis introduces a transverse, symmetry-breaking mode of optomechanical coupling that departs from the conventional dispersive and dissipative interactions, taking its motivating platform from whispering-gallery-mode (WGM) resonators, where a mechanical displacement lifts the near-degeneracy of azimuthal mode pairs and couples them. After reviewing the standard optomechanical model and the sideband-cooling phenomenology it underlies, we derive the Hamiltonian for the transverse-coupling system and first study its Hamiltonian dynamics, without drive or dissipation. Recast in terms of Schwinger pseudospin operators, the model exhibits a Hamiltonian Hopf bifurcation separating stable and unstable dynamical regimes. In the stable regime, the mechanical nonlinearity permits controlled …

Skipping Town: An Examination Of Fugitive Travel Patterns, Flight Duration, And "Journey-From-Crime", Shun Q. Feng

Dissertations, Theses, and Capstone Projects

Purpose: Existing research on fugitive mobility has largely examined fugitive travel patterns and flight duration as separate phenomena, often relying on limited geographic areas or a cross-section of the fugitive population. This dissertation addresses these gaps by examining where fugitives travel relative to their originating county, and how long they avoid apprehension. Utilizing a national sample of fugitives with data provided by the United States Marshals Service (USMS), the study investigates how individual characteristics, situational warrant factors, and county-level characteristics influence fugitive travel patterns across a broader, more comprehensive scope.

Methods: Using data from the Justice Detainee Information System (JDIS) …

Curated Spaces: Cognition By Design, Sydney Harvey

Dissertations, Theses, and Capstone Projects

“Curated Spaces: Cognition by Design” is a dissertation that considers the connection between designed spaces and cognition. This work combines philosophy of mind and aesthetics. The dissertation introduces the term “Curated Cognition”, which builds on the concept of situated cognition ( Brooks, 1991; Odling-Smee, Laland, and Feldman,  2003;  Sterelny, 2010; Krueger, 2015; Colombetti, 2020 ). The dissertation argues that the environment is essential to cognition, and all environments are curated; therefore, the way we think, feel, and act is curated as well. Some non-human animals may inhabit worlds that are not curated. For example, an octopus may find shelter in …