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Articles 40711 - 40740 of 1826599
Full-Text Articles in Entire DC Network
One Young World: #Togetherapart (Podcast Review), Talia Agee
One Young World: #Togetherapart (Podcast Review), Talia Agee
Rushton Journal of Undergraduate Humanities Research
A podcast review of the podcast #TogetherApart produced by the London non-profit One Young World.
Optimized Resnet-18 Architecture For Multi-Class Oral Diseases Classification, Ahmed Ahmed
Optimized Resnet-18 Architecture For Multi-Class Oral Diseases Classification, Ahmed Ahmed
Karbala International Journal of Modern Science
In recent years, the classification of oral diseases has gained significant attention due to its influence on public health and the necessity for early and accurate diagnosis. Traditional diagnosis depends on manual clinical assessment, which can be slow and subjective. An optimized and subsequently quantized model is required to provide a faster and more consistent diagnostic support tool. This paper proposes an optimized ResNet-18 architecture for the classification of six oral diseases. The optimization process is based on removing the Rectified Linear Unit (ReLU), Batch Normalization (BN), and convolutional layers from the base ResNet-18 blocks that contain 128 filters. This …
Sperm-Associated Antigen 6 (Spag6) As A Potential Marker Of Sperm Function In Diagnosing Male Infertility, Ibtisam A. Al-Ali,, Kawkab A. Alsaadi
Sperm-Associated Antigen 6 (Spag6) As A Potential Marker Of Sperm Function In Diagnosing Male Infertility, Ibtisam A. Al-Ali,, Kawkab A. Alsaadi
Karbala International Journal of Modern Science
Background: While male infertility has become a significant global health concern, conventional analysis of semen has not made progress in the detection of contraindicated molecular biomarkers, such as sperm-associated antigen 6 (SPAG6), which is a protein involved in axonemal structure and flagellar motility.
Hypothesis: Expression of SPAG6 correlates with sperm motility and structural integrity. This means that its dysregulation may serve as a molecular indicator of impaired sperm performance.
Methods: A comprehensive review of recent studies was conducted with a focus on SPAG6’s molecular characteristics, expression patterns in normal versus abnormal spermatozoa, and the role it plays in motility-related …
Optimized Co2 Gas Sensing With Sns:Sm2o3/N-Si Nanocomposites Fabricated Via Spray Pyrolysis, Wasan A. Khalaf, Mays A. Hammadi, Mohammed J. Alsultani, Yahya R. Hathal, Mohammed O. Salman
Optimized Co2 Gas Sensing With Sns:Sm2o3/N-Si Nanocomposites Fabricated Via Spray Pyrolysis, Wasan A. Khalaf, Mays A. Hammadi, Mohammed J. Alsultani, Yahya R. Hathal, Mohammed O. Salman
Karbala International Journal of Modern Science
In this work, tin sulfide:samarium oxide (SnS:Sm2O3) composite films were deposited using a spray pyrolysis technique for room-temperature CO2 gas sensing. X-ray diffraction (XRD) confirmed a polycrystalline SnS nature of orthorhombic-phase crystallinity at 10 at.% Sm ions, while 20 at.% Sm induced Sm2O3 as a separate phase. Field emission-scanning electron microscopy (FE-SEM) induced uniform grains and increased the surface roughness, enhancing gas adsorption. UV-visible absorbance revealed band-gap narrowing. Fourier transform infrared spectroscopy (FTIR) analysis revealed vibrational band shifts, confirming the structural modifications. Gas-sensing measurements demonstrated 5.72%, 19.65%, and 9.65% for pure SnS, …
Marketing Strategy In The Age Of Ai, Mary C. Martin
Marketing Strategy In The Age Of Ai, Mary C. Martin
All Open Educational Resources
Marketing Strategy in the Age of AI is an Open Educational Resource designed to help students master foundational marketing strategy while understanding how artificial intelligence is reshaping marketing practice. The textbook emphasizes core strategic thinking and positions AI as a tool that enhances, rather than replaces, human judgment and decision-making. The book covers key areas of marketing strategy across the marketing mix, including environmental analysis, market research, product development, pricing, distribution, and promotion. Each chapter introduces established marketing frameworks and then explores how AI-driven tools and data improve insight, speed, and effectiveness in real-world marketing decisions. Examples and cases highlight …
Rethinking Geoengineering Governance Utilizing The Playing God Argument: Considerations Of Knowledge, Control, And Benevolence, Julian Dreiman, Brian Patrick Green
Rethinking Geoengineering Governance Utilizing The Playing God Argument: Considerations Of Knowledge, Control, And Benevolence, Julian Dreiman, Brian Patrick Green
Staff Publications and Research
Because greenhouse gas emissions continue to grow, it is increasingly challenging to limit global warming to 1.5 or 2.0 degrees Celsius. As such, there is a growing debate on whether or not to deploy geoengineering to reduce warming. Geoengineering is controversial, and many arguments have been raised against it, including the “playing God” critique. When understood through the philosopher Moti Mizrahi’s reinterpretation, the playing God critique does not eliminate the possibility of using geoengineering, but rather informs how its governance can be improved. We use Mizrahi’s interpretation of the playing God critique to claim that the existing governance literature lacks …
Acronyms And Definitions, Alice Dell'era
Acronyms And Definitions, Alice Dell'era
Course Materials
This file compiles a list of key acronyms and definitions.
Water Budget For Monitored Watersheds At The Edwards Aquifer Authority Field Research Park: Report For The Edwards Aquifer Authority, Keagan Farrell, Tatiana Flores, Isabella Lopez, Kemerling Obregon Lucio, Gisele-Elizabeth Perez, Andrea Realyvasquez, Magali Rodriguez, Kelly Swyers, Adan Vasquez
Water Budget For Monitored Watersheds At The Edwards Aquifer Authority Field Research Park: Report For The Edwards Aquifer Authority, Keagan Farrell, Tatiana Flores, Isabella Lopez, Kemerling Obregon Lucio, Gisele-Elizabeth Perez, Andrea Realyvasquez, Magali Rodriguez, Kelly Swyers, Adan Vasquez
Hydrogeology
The purpose of the study was to determine the change in storage of two water sheds after the impact of two rain events, considering factors such as rainfall, discharge and infiltration, and evapotranspiration. The two sub-watersheds, located on the Edward’s Aquifer Authority Field Research Park, each had a weir. The larger of the two watersheds was named Watershed 1, while the smaller one was named Watershed 2. Watershed 1 was where the weir named Arnold was located, while watershed 2 was where the weir named Danny was located. Inflow and outflow were calculated by analyzing precipitation data and water flow …
Investigating The Role Of Team Chemistry In Winning Percentage Of Collegiate Women’S Soccer Teams At The End Of A Fall Competitive Season, Erin Kasmarik-Mallett
Investigating The Role Of Team Chemistry In Winning Percentage Of Collegiate Women’S Soccer Teams At The End Of A Fall Competitive Season, Erin Kasmarik-Mallett
Doctorate in Kinesiology
This study examined the relationship between team chemistry and winning percentage in collegiate women’s soccer teams following a fall competitive season. Using a quantitative, correlational design, team-level survey data assessing cohesion, team mental models, collective efficacy, and leadership were aggregated and analyzed in relation to end-of-season performance. Pearson correlations and linear regression analyses indicated a positive association between overall team chemistry and winning percentage, with team mental models and collective efficacy showing the strongest relationships. These findings support team chemistry as a measurable, multidimensional contributor to performance success and provide empirical guidance for coaches seeking evidence-based strategies to enhance team …
21st-Century Mangrove Expansion Along The Southeastern United States, Lucia I.A. Enes Gramoso, Dustin Carroll, Kyle C. Cavanaugh, Remi Bardou, Michael J. Osland, Tom Van Der Stocken
21st-Century Mangrove Expansion Along The Southeastern United States, Lucia I.A. Enes Gramoso, Dustin Carroll, Kyle C. Cavanaugh, Remi Bardou, Michael J. Osland, Tom Van Der Stocken
Faculty Research, Scholarly, and Creative Activity
Warming winter temperatures are driving range expansion of tropical, cold-sensitive mangroves into temperate ecosystems. Along the Atlantic coast of North America, the mangrove range limit is particularly sensitive to climate variability and historical data demonstrate that the mangrove-salt marsh ecotone on this coast has shifted recurrently during recent centuries. However, a comprehensive understanding of how this mangrove-salt marsh ecotone may shift in the future remains lacking. Here, we combine ensemble forecasting of mangrove distribution for the next century with high-resolution oceanographic dispersal simulations, phenological observations, and historical hurricane data to project future mangrove-salt marsh dynamics at the rapidly changing range …
Re: Conditional Approval Letter For The Draft Final Butte Reduction Works (Brw) Smelter Area Mine Waste Remediation And Contaminated Groundwater Hydraulic Control Site Pre-Design Investigation (Pdi) Evaluation Report (Dated September 12, 2025), Emma Rott
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Collaborating With ‘Blue Food’ System Stakeholders To Achieve Optimal Nutritional Health And Wellbeing In Less Affluent Communities, Clare Pettinger, Louise Hunt, Carol Wagstaff
Collaborating With ‘Blue Food’ System Stakeholders To Achieve Optimal Nutritional Health And Wellbeing In Less Affluent Communities, Clare Pettinger, Louise Hunt, Carol Wagstaff
School of Health Professions
UK food system transformation is urgently needed, but to date, minimal research has investigated ‘blue foods’ probably because they are ethically nuanced. There exists a paradox whereby materially deprived communities should be eating more fish to meet nutritional requirements, yet there is a global ‘red flag’ around global overfishing. New collaborative and creative solutions are, therefore, needed to tackle such food system inequities. By working together, all voices can be equally heard when decisions are being made to improve the system. Similarly, innovation and disruption of established supply chains will enable better access to healthy, affordable and tasty food that …
Impact Of Grain Size On Low-Temperature Carrier Phase Coherence Length In Polycrystalline Halide Perovskite Films, Aungkan Sen, Liam J. Scanlon, Axel Melchor Gaona Carranza, Jose L. Mendoza-Cortes, Johannes Pollanen, Richard R. Lunt, William J. Gannon
Impact Of Grain Size On Low-Temperature Carrier Phase Coherence Length In Polycrystalline Halide Perovskite Films, Aungkan Sen, Liam J. Scanlon, Axel Melchor Gaona Carranza, Jose L. Mendoza-Cortes, Johannes Pollanen, Richard R. Lunt, William J. Gannon
Physics and Astronomy Faculty Publications
Halide perovskites are now being studied for a full range of optoelectronic devices due to their excellent electronic and optical properties. This work explores the impact of grain boundaries on low-temperature carrier transport in polycrystalline cesium tin iodide (CsSnI3) within the quantum diffusive transport regime, comparing a range of polycrystalline samples with varying grain sizes with epitaxial counterparts. Low-temperature magnetoresistance measurements reveal the presence of weak anti-localization (spin-orbit effects) with a shorter coherence length (Lϕ) than the epitaxial films. Surprisingly, Lϕ is not found to be impacted by grain size, despite being nearly an order …
Distribution Of New Statistics Of Parking Functions And Their Generalizations, Stephan Wagner, Catherine H. Yan, Mei Yin
Distribution Of New Statistics Of Parking Functions And Their Generalizations, Stephan Wagner, Catherine H. Yan, Mei Yin
Mathematics: Faculty Scholarship
In this paper we present new results on the enumeration of parking functions and labeled forests. We introduce new statistics on parking functions, which are then extended to labeled forests via bijective correspondences. We determine the joint distribution of two statistics on parking functions and their counterparts on labeled forests. Our results on labeled forests also serve to explain the mysterious equidistribution between two seemingly unrelated statistics in parking functions recently identified by Stanley and Yin and give an explicit bijection between the two statistics. Extensions of our techniques are discussed, including joint distribution on further refinement of these new …
2025 Uninsured Adult Healthcare Safety Net Annual Report, Tennessee. Department Of Health.
2025 Uninsured Adult Healthcare Safety Net Annual Report, Tennessee. Department Of Health.
Healthcare Safety Net Annual Report
No abstract provided.
Evaluating Impact Of Occupational Exoskeletons On Physical Fatigue Using Wearable Sensors And Deep Learning, Hardik Vora, Fatemeh Davoudi Kakhki, Armin Moghadam
Evaluating Impact Of Occupational Exoskeletons On Physical Fatigue Using Wearable Sensors And Deep Learning, Hardik Vora, Fatemeh Davoudi Kakhki, Armin Moghadam
Faculty Research, Scholarly, and Creative Activity
Musculoskeletal disorders remain a leading source of occupational injury in manufacturing and logistics industries, often resulting from repetitive lifting and load transfer tasks. While back-support exoskeletons have shown promise in alleviating physical strain, their biomechanical impact under realistic task conditions and their integration with intelligent monitoring systems require further exploration. This study investigates the efficacy of a passive lumbar-support exoskeleton in reducing muscle fatigue during manual material handling tasks by combining high-resolution surface electromyography (sEMG) data with a deep learning-based classification framework. Ten participants performed lifting and rotational (twisting) tasks with and without exoskeleton assistance, while EMG signals were collected …
Enhanced Confocal Microscopy With Physics-Guided Autoencoders Via Synthetic Noise Modeling, Shyam Pokharel
Enhanced Confocal Microscopy With Physics-Guided Autoencoders Via Synthetic Noise Modeling, Shyam Pokharel
All Publications
We present a Physics-guided deep learning framework to address common limitations in Confocal Laser Scanning Microscopy (CLSM), including diffraction-limited resolution, noise, and under sampling due to low laser power conditions. The optical system’s point spread function and primary CLSM image degradation mechanisms, namely photon shot noise, dark current noise, motion blur, speckle noise, and under sampling are explicitly incorporated into the model as physics-based constraints. A convolutional autoencoder is trained with a custom loss function that integrates these optical degradation processes, ensuring that the reconstructed images adhere to physical image formation principles. The model is evaluated on simulated CLSM datasets …
Embedding Interprofessional Education In Pediatric Clerkships: Lessons From Nebraska’S Tracking Infant Progress Statewide (Tips) Program, Grace E. Berentson, Liliana Bronner, Paige Hardy, Neil Kalsi, Brianna Brei, Kerry Miller
Embedding Interprofessional Education In Pediatric Clerkships: Lessons From Nebraska’S Tracking Infant Progress Statewide (Tips) Program, Grace E. Berentson, Liliana Bronner, Paige Hardy, Neil Kalsi, Brianna Brei, Kerry Miller
Posters and Presentations: Munroe-Meyer Institute
Background: NICU graduates experience disproportionate developmental and health challenges. Their families face barriers to equitable care including access to coordinated follow-up services. Traditional medical education rarely exposes students to authentic interprofessional models of care that address these inequities. The Tracking Infant Progress Statewide (TIPS) program provides developmental, social, and medical follow-up for NICU graduates across Nebraska, bringing together physicians, nurse practitioners, child developmental specialists, and nurses in a single family-centered visit. Embedding third-year medical students into this setting models collaborative practice, builds understanding of interprofessional competencies, and fosters awareness of systemic inequities affecting NICU families. This innovative curricular approach differs …
The Virtual Kitchen Challenge-Version 2: Validation Of A Digital Assessment Of Everyday Function In Older Adults, Marina Kaplan, Moira Mckniff, Stephanie M. Simone, Molly B. Tassoni, Katherine Hackett, Sophia Holmqvist, Rachel E. Mis, Kimberly Halberstadter, Riya Chaturvedi, Melissa Rosahl, Giuliana Vallecorsa, Mijail Serruya, Deborah A. G. Drabick, Takehiko Yamaguchi, Tania Giovannetti
The Virtual Kitchen Challenge-Version 2: Validation Of A Digital Assessment Of Everyday Function In Older Adults, Marina Kaplan, Moira Mckniff, Stephanie M. Simone, Molly B. Tassoni, Katherine Hackett, Sophia Holmqvist, Rachel E. Mis, Kimberly Halberstadter, Riya Chaturvedi, Melissa Rosahl, Giuliana Vallecorsa, Mijail Serruya, Deborah A. G. Drabick, Takehiko Yamaguchi, Tania Giovannetti
Department of Medicine Faculty Papers
BACKGROUND: Conventional methods of functional assessment include subjective self- or informant report, which may be biased by personal characteristics, cognitive abilities, and lack of standardization (eg, influence of idiosyncratic task demands). Traditional performance-based assessments offer some advantages over self- or informant reports but are time-consuming to administer and score.
OBJECTIVE: This study aims to evaluate the validity and reliability of the Virtual Kitchen Challenge-Version 2 (VKC-2), an objective, standardized, and highly efficient alternative to current functional assessments for older adults across the spectrum of cognitive aging, from preclinical to mild dementia.
METHODS: A total of 236 community-dwelling, diverse older adults …
Leveraging Wastewater Resource Recovery To Reduce Landfill Organic Loading: Process Modeling, Environmental, And Economic Impact Assessment, Ahmed I. Yunus, Arjun T. Ramshankar, Zainab O. Akinsemoyin, Thomas Igou, Ameet Pinto, George Fu, Yongsheng Chen, Joe F. Bozeman Iii
Leveraging Wastewater Resource Recovery To Reduce Landfill Organic Loading: Process Modeling, Environmental, And Economic Impact Assessment, Ahmed I. Yunus, Arjun T. Ramshankar, Zainab O. Akinsemoyin, Thomas Igou, Ameet Pinto, George Fu, Yongsheng Chen, Joe F. Bozeman Iii
Civil Engineering & Construction: Faculty Publications
No abstract provided.
Wikipedia And Archival Internships: Preparing Memory Workers For Inclusive Practice, April K. Anderson-Zorn
Wikipedia And Archival Internships: Preparing Memory Workers For Inclusive Practice, April K. Anderson-Zorn
Faculty and Staff Publications – Milner Library
Archival internships guided by the Rayfield Archives offer opportunities for future archivists, public historians, and other memory workers to gain hands-on experience working with historical records and their communities. Along with archival processing, exhibit curation, and metadata, interns can also learn to create authoritative Wikipedia entries for underrepresented members of the ISU community. From its early, grant-funded stages in 2020 to its current iteration as an interactive, guided project, the Wikipedia internship at the Rayfield Archives prepares students for inclusive practice in memory work in the classroom and the field.
Experimental And Simulation Analysis For Different Pot-In-Pot Indirect Heating Scenarios For Cooking Applications, Pamella K. Kajumba, Jimmy Chaciga, Denis Okello, Karidewa Nyeinga
Experimental And Simulation Analysis For Different Pot-In-Pot Indirect Heating Scenarios For Cooking Applications, Pamella K. Kajumba, Jimmy Chaciga, Denis Okello, Karidewa Nyeinga
Tanzania Journal of Science
The paper presents simulation and experimental results to demonstrate heat transfer performance during cooking that can be practical in pot-in-pot arrangements for indirect cooking/heating. The cases included single pots, pot-in-pot with oil, and pot-in-pot with no oil. The aim was to optimize the heat transfer through conduction and the cooking process for a recently developed small-scale sensible heat storage system integrated with a cooking unit. Cooking experiments reported were carried out using an electric hot plate with a power rating of 1.8 kW, 220V. Temperature measurements were recorded using a TC-08 data logger. The heating rates were analyzed for the …
Appropriate Wireless Technology For Blue Data Communication To Enhance Artisanal Fishery, Abdi T. Abdalla, Eva Shayo, Angelina Misso, Baraka Maiseli, Kwame S. Ibwe, Narriman Jiddawi, Moses Ismail
Appropriate Wireless Technology For Blue Data Communication To Enhance Artisanal Fishery, Abdi T. Abdalla, Eva Shayo, Angelina Misso, Baraka Maiseli, Kwame S. Ibwe, Narriman Jiddawi, Moses Ismail
Tanzania Journal of Science
The paper examines the development of a system architecture to support smart fishing. This includes the establishment of a blue data center, which would allow government agencies and research institutions to access fisheries data. The goal is to provide policymakers with the tools they need to efficiently manage artisanal fisheries resources. The architecture also incorporates wireless communication components that are suitable for small-scale fishers in remote areas. The study delves into the selection of appropriate wireless communication technology for transmitting fishing data to the communication center. Factors such as coverage range, data rates, and cost implications are taken into consideration. …
Qualitative And Numerical Observations Into The Career Trajectories Of Early Career Academics: A Mathematical Model Approach, Oluwatayo M. Ogunmiloro
Qualitative And Numerical Observations Into The Career Trajectories Of Early Career Academics: A Mathematical Model Approach, Oluwatayo M. Ogunmiloro
Tanzania Journal of Science
This study develops and analyzes a mathematical model that describes the interplay among different researcher groups within academia by focusing on how variables such as mentorship, access to funding, and academic peer influence affect the career trajectories of early-career, experienced, redundant, and successful researchers. Using stability theory and relevant theorems of differential equations, this study ensures the existence, uniqueness, positivity, and boundedness of the model's solutions. Additionally, the model’s equilibrium states, are analyzed to determine the local asymptotic stability. Numerical simulations using the Runge-Kutta fourth-order (RK4) method, implemented in Python, are performed to illustrate issues related to career growth within …
Re: Comment Letter For Draft Clark Tailings Consolidated Waste Management Area (Ctcwma) 2024 Data Summary Report (Dated October 15, 2025), Emma Rott
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Read My Lips: No New Constructs! Construct Proliferation As A Threat To The Future Of I-O Psychology, Nathan A. Bowling, Valerie I. Sessa, Jonathan A. Shaffer, George C. Banks
Read My Lips: No New Constructs! Construct Proliferation As A Threat To The Future Of I-O Psychology, Nathan A. Bowling, Valerie I. Sessa, Jonathan A. Shaffer, George C. Banks
Department of Psychology Faculty Scholarship and Creative Works
Industrial and organizational (I-O) psychology recognizes dozens of different constructs, including several individual differences, environmental variables, job attitudes, and work-related behaviors. It is, of course, necessary to retain a variety of constructs in order to adequately capture the complexities, subtleties, and diversity of work-related phenomena. But do the many constructs recognized by I-O psychologists all serve a useful purpose? Or has our field been too eager to welcome redundant, unnecessary constructs into the fold? And if I-O psychology has embraced too many unnecessary constructs, then what—if anything—should we do about it? In the current focal article, we first discuss when …
Powering Up Clinical Scholarship In Evidence-Based Practice For Nurse Residents, Evelyn Wang
Powering Up Clinical Scholarship In Evidence-Based Practice For Nurse Residents, Evelyn Wang
HSLIC Faculty and Staff Instructional Resources
This Nurse Residency Evidence-Based Practice workshop introduces core concepts of clinical scholarship for nurse residents, emphasizing how to turn clinical questions into structured literature searches and use HSLIC resources to support scholarly projects. Topics include framing answerable clinical questions (e.g., PICOT), navigating key clinical information tools (PubMed, CINAHL, PsycINFO, EMBASE, ClinicalKey, UpToDate), applying practical literature search techniques (Boolean operators, truncation, wildcards, proximity operators, subject headings), documenting basic search strategies, accessing full text (LibKey Nomad, proxy authentication, interlibrary loan and document delivery), and a brief introduction to critical appraisal tools and publishing supports available through HSLIC.
The Effect Of Exercise On Cognitive Function In The Elderly, Anna Petersen
The Effect Of Exercise On Cognitive Function In The Elderly, Anna Petersen
Advocate GME
No abstract provided.
Assessing The Effects Of Ehealth Literacy And The Area Deprivation Index On Barriers To Electronic Patient Portal Use For Orthopedic Surgery: Cross-Sectional Observational Study, Audrey Lynn Litvak, Nicholas Lin, Kelly Hynes, Jason Strelzow, Jeffrey G Stepan
Assessing The Effects Of Ehealth Literacy And The Area Deprivation Index On Barriers To Electronic Patient Portal Use For Orthopedic Surgery: Cross-Sectional Observational Study, Audrey Lynn Litvak, Nicholas Lin, Kelly Hynes, Jason Strelzow, Jeffrey G Stepan
2020-Current year OA Pubs
BACKGROUND: As electronic patient portals (EPPs) continue to gain popularity and systems transition to online tools for scheduling, communication, and telehealth, patients without access or skills to use these tools may be overlooked.
OBJECTIVE: This study analyzed patient and neighborhood-level factors, including eHealth literacy level and the Area Deprivation Index (ADI), that may limit EPP access for orthopedic surgery.
METHODS: A cross-sectional, survey-based study was performed at a single urban tertiary academic medical center in the United States across foot and ankle, hand and upper extremity, and orthopedic trauma subspecialty clinics from June 21, 2022, to August 12, 2022. Survey …
3d Reconstruction Of Spatial Transcriptomics With Spatial Pattern Enhanced Graph Convolutional Neural Network, Chen Tang, Yuansheng Zhou, Xue Xiao, Lei Dong, Lei Yu, Guanghua Xiao
3d Reconstruction Of Spatial Transcriptomics With Spatial Pattern Enhanced Graph Convolutional Neural Network, Chen Tang, Yuansheng Zhou, Xue Xiao, Lei Dong, Lei Yu, Guanghua Xiao
Faculty, Staff and Student Publications
Spatially resolved transcriptomics (SRT) is a promising new technology that enables simultaneous analysis of gene expression and spatial information for biomedical research. However, the existing statistical and deep learning algorithms used for analyzing SRT data rely solely on two-dimensional (2D) spatial coordinates, which limits their ability to accurately identify spatial domains, spatially variable genes (SVGs), cell-to-cell communications, and developmental trajectories in a three-dimensional (3D) spatial manner. To address these limitations, we introduced Spa3D, which utilized the anti-leakage Fourier transform and graph convolutional neural network model to reconstruct 3D-based spatial structures from multiple 2D SRT slices. We demonstrate that Spa3D is …