Digital Commons Network^™

Tumor Radiosensitization With Gold Nanoparticles: Evolving Strategies To Improve Tumoral Gold Uptake And Catalyze Future Clinical Translation, Prapannajeet Biswal, Geraldine V Vijay, Gabrielle Krouse, Phuoc Minh Quan Mai, Bhoomika Muruvekere Lakshmisha, Mahdieh Yousefi Taba, Lydia Wt Cheung, Yuri Mackeyev, Khadijeh Koushki, Sunil Krishnan

Faculty, Staff and Student Publications

Radiation therapy is integral to the treatment regimens of over 50% of cancer patients. However, it is not biologically targeted to just the tumor, leading to adverse effects in peritumoral normal tissue. Selective uptake of gold nanoparticles (AuNPs) by tumors realizes tumor-specific radiosensitization via increased secondary electron release from high atomic number gold atoms. Here, we review AuNP-mediated radiosensitization and outline strategies to optimize tumor-targeted AuNP delivery. Modifying the physicochemical characteristics of AuNPs, including size, shape, charge, and surface chemistry, can increase their ability to evade the reticuloendothelial system (RES) and penetrate the dense tumor stromal architecture, thereby promoting tumor …

Ubiquitination Of Oncogenic Mutant P53 Via Attenuation Of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth, Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez, Andrew Massey, Neeraj Chauhan, Manish K Tripathi, Dae J Kim, Nirakar Sahoo, Tamer Oraby, Murali M Yallapu, Mohammad Moshahid Khan, Manu M Sebastian, Subhash C Chauhan, Bilal B Hafeez

Faculty, Staff and Student Publications

Dysregulated ribosome biogenesis and p53 mutations are known to play oncogenic roles in various cancers, including pancreatic cancer. In this study, we demonstrated the therapeutic potential of BMH-21, a pharmacologic inhibitor of RNA polymerase I, against pancreatic cancer by uncovering a novel molecular mechanism involving RPA194-mediated ubiquitination of mutant p53 without affecting the ubiquitination of wild-type p53. Our key findings are that (i) BMH-21 selectively induces apoptosis and cell growth inhibition of pancreatic cancer cells with no effect on normal human pancreatic ductal epithelial cells; (ii) BMH-21 degrades RPA194; (iii) BMH-21 inhibits recruitment of both RPA194 and RPA135 on rDNA …

2026-02-04 Border Protection Office Of Professional Responsibility Declines Career Fair Invitation, Kean Mathis

The Spectator Online

No abstract provided.

A Case Of Dislocation And Successful Reduction Of A Right Anterior Shoulder Inside A Space Suit: Considerations For Future Protocols, Brandon Trapp

Faculty, Staff and Student Publications

Shoulder dislocations are prevalent on Earth and pose unique challenges in spaceflight and spaceflight training, particularly during extravehicular activities (EVAs). This case report describes a 50-year-old male who experienced an anterior shoulder dislocation while performing an emergency egress exercise in a SpaceX EVA suit. The report describes the medical thought process, the operational constraints, and the reduction techniques employed to achieve a successful shoulder reduction without fully removing or damaging the suit. NASA estimates a high likelihood of shoulder injuries during long-duration lunar missions, emphasizing the importance of suit designs and rescue protocols. Quick and effective medical intervention is crucial, …

Geochemical Fate Of Lead In Contaminated Residential Soils Following Application Of Amendments For Lead Immobilization, Hadeer Saleh, Washington Braida, Zhiming Zhang, Rupali Datta, Dibyendu Sarkar

Michigan Tech Publications

Background: Lead (Pb) persists in urban soils, where its partitioning among geochemical fractions governs mobility, bioavailability, and human health risk. These fractions are strongly controlled by soil physicochemical properties, necessitating site-specific remediation strategies. Methods: This study developed a site-specific Pb immobilization framework linking amendment selection to soil geochemistry and sustainability considerations. Pb-contaminated residential soils from three U.S. cities, San Antonio (alkaline), Baltimore (acidic), and Detroit (near-neutral), were treated with gypsum, biochar + lime, and alum, respectively. Changes in Pb speciation were tracked using sequential extraction over 7, 30, and 90 days. Results: All amendments significantly reduced exchangeable Pb (F1) and …

Protocol For Personalised Prediction Of Persistent Postsurgical Pain, Katherine J Holzer, Harutyun Alaverdyan, Ziqi Xu, Madelyn R Frumkin, Karen A Frey, Stephen H Gregory, Thomas L Rodebaugh, Chenyang Lu, Christopher R King, Denise Head, Thomas Kannampallil, Simon Haroutounian

2020-Current year OA Pubs

INTRODUCTION: Persistent postsurgical pain (PPSP) affects up to 15% of patients after major surgery, impairing physical function, quality of life and increasing risk for long-term opioid use. Current PPSP prediction models rely on static or retrospective data and fail to incorporate dynamic perioperative factors. The Personalised Prediction of Persistent Postsurgical Pain (P5) study aims to develop individualised, multimodal prediction models by integrating preoperative behavioural, psychophysical and neurocognitive assessments and high-frequency symptom monitoring.

METHODS AND ANALYSIS: P5 is a prospective, single-centre cohort study enrolling 2500 adults aged 18-75 undergoing major surgery at a tertiary academic hospital. Participants complete baseline surveys, cognitive …

Competitive Advantage Strategies For Independent Restaurant Owners, Bobby Mccrary

Walden Dissertations and Doctoral Studies

Independent restaurant owners often face challenges in achieving a sustainable competitive advantage, resulting in poor business performance and loss of profitability. Identifying practical competitive advantage strategies is essential for independent restaurant owners to surpass five years of business operations. Grounded in resource-based view theory, the purpose of this multiple case study was to explore effective competitive advantage strategies independent restaurant owners used to sustain operations beyond five years. Purposeful sampling was used to select four independent restaurant owners located in Wichita, Kansas, who sustained operations beyond five years through competitive advantage strategies. Data were collected from semistructured interviews and from …

Exploring Leadership Strategies To Foster Effective Employee Engagement, Antonwaun Johnson

Walden Dissertations and Doctoral Studies

Employee disengagement is an organizational disruption that erodes trust, weakens culture, and undermines the performance systems leaders depend on to drive results. Functional leaders are concerned with employee disengagement because it can lead to poor organizational performance and affect organizational success. Grounded in leader–member exchange (LMX) theory, the purpose of this qualitative pragmatic inquiry was to explore effective strategies functional leaders use to foster employee engagement in a working environment to enhance organizational success. The project participants were six functional leaders working in an e-commerce order fulfillment center in the southeastern United States. Data were collected through semistructured interviews and …

Agentic Ai Framework For Semantic Transaction Data Compression And Retrieval, Palakh Shangle

Defensive Publications Series

The present disclosure relates to the field of Artificial Intelligence (AI), in particular to agentic AI framework for semantic transaction data compression and retrieval. The disclosed system comprises a plurality of AI agents, including an ingest agent, a selector agent, an encoder agent, a retriever agent and a governance agent, collectively configured to process large volumes of transaction records generated by electronic payment networks. In operation, transaction records are ingested, normalized, and analyzed to dynamically determine an appropriate compression policy based on storage efficiency, semantic fidelity and retrieval latency. Compressed transaction data is stored in an object storage system along …

Achieving Dynamic Urpf With Route Scale Optimizations, Anonymous

Defensive Publications Series

Systems and methods are disclosed for achieving dynamic Unicast Reverse Path Forwarding (uRPF) with route scale optimizations in an IP routing device, in which ingress traffic is sampled and analyzed to detect conditions indicative of source address spoofing or related attacks, and upon detecting such a condition, a control plane automatically enables uRPF at a selected scope including globally, per virtual routing and forwarding instance (VRF), and/or per interface, and subsequently disables uRPF once the attack condition subsides for at least a configured inactivity interval. Because enabling uRPF can reduce the maximum number of routes installable in a hardware forwarding …

Efficient Machine Learning And Serving Using Disjoint Hamiltonian Cycles, N/A

Defensive Publications Series

The technology described in this paper relates to the use of disjoint Hamiltonian cycles to support asymmetric communication patterns effectively while maintaining desirable latency control properties of direct-connect topologies. The technique used in this paper dynamically re-maps fixed disjoint dimensions of a direct-connect topology into a flexible set of disjoint Hamiltonian cycles that can trade network dimensions and the bandwidth-per-dimension to support asymmetric communication patterns. The mapping of the asymmetric network onto Hamiltonian cycles enables dividing the workload across Hamiltonian cycles of equal length.

Pipelined Execution Of Attention And Feed-Forward Network Operations On Heterogeneous Cores For Llm Decode Acceleration, N/A

Defensive Publications Series

The technology described in this paper relates to maximization of resource utilization for transformer based large language models (LLMs), specifically during an autoregressive decode phase. For the decode phase, each layer of a transformer model is primarily composed of two distinct computational blocks, an attention operator block and a feed-forward network (FFN) operator block. The attention operator block is overwhelmingly memory-bandwidth bound. In contrast, the FFN operator block is largely compute-bound, and the computations are dominated by large dense matrix multiplications. A chip architecture may be provided that contains at least two types of specialized co-located cores, a first core …

Large Language Model (Llm) – Agent System For Register Transfer Level (Rtl) Transformation, N/A

Defensive Publications Series

The technology described in this paper relates to transformation of functional register-transfer level (RTL) hardware designs for implementation by electronic design automation (EDA) physical synthesis tools. An intelligent, autonomous, and self-correcting RTL transformation system that is based on large language models (LLMs) is proposed. The system includes an LLM agent that is based on one or more LLM models, and a robust closed-loop transformation validation agent that is integrated with the LLM agent. A continuous feedback loop is used to allow the agent for RTL transformation validation to provide feedback to the LLM agent as error messages. The LLM interprets …

Divorce Of International Mixed Marriage And Marriage Held Abroad And Indonesian Private International Law, Tiurma M. Pitta Allagan

Indonesian Journal of International Law

The unstoppable tide of globalism not only brings an increasing commercial interconnectivity between nations, but also bonds of matrimony, and in turn, the chance of divorce. Indonesian courts entertaining international divorce cases is certainly not a rarity, neither divorce of the international mixed marriage nor the marriage that was held abroad. With two recent divorce cases having a foreign element, Indonesian courts declared having no jurisdiction under grounds of “litis pendentie” and forum non-convenience, including one by the Indonesian Supreme Court. In three other cases, the courts, after addressing the preliminary question of marriage, applied the “lex fori”, or Indonesian …

Legal Implications Of The Mauritius V Maldives Case On The Delimitation Of Archipelagic States, Aishath Ruhsha Nasheed, Mohd Hisham Mohd Kamal

Indonesian Journal of International Law

Maritime boundary delimitation is a complex field of international law characterized by uncertainty and unpredictability. Historically, States have relied on case law to develop and elaborate on the ambiguous provisions stipulated under the United Nations Convention on the Law of the Sea (UNCLOS) concerning maritime boundary delimitation. However, case law related to the maritime delimitation of archipelagic States is limited, leading to conflicting interpretations of the basic principles of maritime delimitation in the context of archipelagic States. This paper aims to examine the legal implications of the latest Mauritius v. Maldives case on the maritime boundary delimitation of archipelagic States. …

Rethinking Jewish Representation Amid Rising Antisemitism, Dereck Daschke

Journal of Religion & Film

A report on a panel that occurred at the 2026 Sundance Film Festival, "Rethinking Jewish Representation Amid Rising Antisemitism: Leveraging Insights from Our Groundbreaking USC “Jews on Screen” Study to Advance Narrative Change," presented by JITC (Jewish Institute for Television & Cinema) Hollywood Bureau.

Time And Water, Sheila Nayar

Journal of Religion & Film

This is a film review of Time and Water (2026), directed by Sara Dosa.

Ghost Story, Jan Beatty

Creative Nonfiction Magazine

No abstract provided.

The Preacher Says, Malcolm Cash

Creative Nonfiction Magazine

No abstract provided.

Language At Play, Diane Ackerman

Creative Nonfiction Magazine

No abstract provided.

Skin Deep, Megan Foss

Creative Nonfiction Magazine

No abstract provided.

Passing Through Pittsburgh, Hilary Masters

Creative Nonfiction Magazine

No abstract provided.

The Conjurer's Profession, Lester Goran

Creative Nonfiction Magazine

No abstract provided.

Notes From The Catwalk, Elissa Wald

Creative Nonfiction Magazine

No abstract provided.

Notes For Young Writers, Annie Dillard

Creative Nonfiction Magazine

No abstract provided.

Soul In A Bottle, Madison Smartt Bell

Creative Nonfiction Magazine

No abstract provided.

Cover To Cover: Reviews Of New Books, Laurie Graham, Lea Simonds

Creative Nonfiction Magazine

No abstract provided.

I Haven't Been That Far, But I'Ve Been To Norwood, Charles Fanning

Creative Nonfiction Magazine

No abstract provided.

Void And Voice: Notes From Poland, Kenneth Sherman

Creative Nonfiction Magazine

No abstract provided.

Misgivings, C.K. Williams

Creative Nonfiction Magazine

No abstract provided.