Digital Commons Network^™

Adipocyte-Specific Deletion Of Sine Oculis Homeobox Homolog 1 Inhibits Lipolysis And Reduces Skin Fibrosis, Nancy Wareing, Tingting W Mills, Scott Collum, Minghua Wu, Lucy Revercomb, Hui Liu, Mikhail Kolonin, Marka Lyons, Brian Skaug, Weizhen Bi, Meer A Ali, Haniyeh Koochak, Anthony R Flores, Yuntao Yang, W Jim Zheng, William R Swindell, Shervin Assassi, Harry Karmouty-Quintana

Faculty, Staff and Student Publications

Dermal fibrosis is a cardinal feature of systemic sclerosis (SSc) for which there are limited Systemic sclerosis (SSc) is characterized by dermal fibrosis accompanied by loss of dermal white adipose tissue (DWAT), yet the mechanisms linking adipocyte depletion to fibroblast activation remain unclear. Here we identify the transcription factor SIX1 as a central regulator coupling adipogenic repression with profibrotic signaling. SIX1 expression was increased in skin biopsies from two independent SSc cohorts and localized to fibroblast and perivascular stromal cells. In mice, ubiquitous or adipocyte-specific deletion of Six1 preserved DWAT, reduced collagen accumulation, and selectively decreased pro-fibrotic mediators. In cultured …

The Overlooked Burden: Anti-Seizure Medications, Laxatives, And Antipsychotics Prescribed In Primary Care For People With Intellectual Disability, Rohit Shankar, Richard Laugharne, Ian Wilson, Mike Wilcock

Peninsula Medical School

Objectives: People with intellectual disabilities (PwID) have higher prevalences of epilepsy and constipation than the general population. Constipation is having fewer than three bowel movements or requiring laxatives three or more times weekly. Both epilepsy and constipation contribute significantly to premature mortality. To manage constipation, many individuals are prescribed long-term laxatives, which serve as a surrogate indicator of constipation. PwID and epilepsy also have a high prevalence of multimorbidity and polypharmacy, particularly involving antiseizure medications (ASMs) and antipsychotics. This study aimed to explore associations between ASM use, antipsychotics, and laxative prescribing.Method: The primary care dataset in Cornwall, England (population 572,000), …

A Transcriptional Program Associated With Neurotransmission In The Living Human Brain, Alexander W. Charney, Lora E. Liharska, Eric Vornholt, Alissa Valentine, Anina Lund, Alice Hashemi, Ryan C. Thompson, Terry Lohrenz, Jessica S. Johnson, Nicole Bussola, Esther Cheng, You Jeong Park, Salman Qasim, Alisha Aristel, Lillian Wilkins, Kimia Ziafat, Hannah Silk, Lisa M. Linares, Brendan Sullivan, Claudia Feng, Beniamino Hadj-Amar Ph.D.

Faculty Publications

At the foundation of neurotransmission, and by extension at the foundation of brain function, are coordinated programs of gene expression involving many thousands of genes. These programs are poorly defined in humans because most modern studies that characterize human brain gene expression use tissue obtained in the postmortem state when neurotransmission and brain function have ceased. Here, to advance knowledge of the gene expression programs at the foundation of neurotransmission in the human brain, gene expression was characterized in 130 prefrontal cortex (PFC) samples obtained from participants of the Living Brain Project (LBP) during neurosurgical procedures in conjunction with intracranial …

Environmental Chemicals And Maternal Depression During And After Pregnancy: A Scoping Review, Pengfei Guo, Yunyue Shi, Cindy Nguyen, Haoran Zhuo, Tormod Rogne, Zeyan Liew

Faculty Publications

Purpose of Review

There is increasing evidence that several environmental exposures may pose a risk for depression, including maternal depression. We conducted a scoping review of epidemiological evidence regarding maternal exposure to environmental chemicals and perinatal depression.

Recent Findings

We searched PubMed, Embase, Web of Science, Dimensions, and Scopus, and summarized the findings from 27 articles that examined environmental chemical exposures and maternal depression. Studies of ambient air pollutants (N = 11) showed exposure to NO₂ and PM10 to be most consistently associated with antenatal or postnatal depression. Studies of endocrine-disrupting chemicals, including phthalates (n = 6), …

Tunable Gold Nanoparticle Synthesis Using Microfluidic Flow Focusing Enabled By Reusable 3d-Printed Multimaterial Connectors, Muhammad Mubashar Saeed, Bilal Javed, Eadaoin Carthy, Nicholas Dunne, David Kinahan

Research Outputs: 2025-Present

The design and fabrication of reusable, cost-effective, and leakage-resistant microfluidic connectors using a commercial multi-material 3D printer (Connex Objet 3D, Tri-Tech 3D, UK) is reported. The connectors, comprising plugs, adapters, and ports, were fabricated from VeroClear™ (rigid polymer) and incorporated TangoBlack (elastomeric soft polymer) as integrated ferrules and gaskets. This multi-material approach enabled the attachment of the connectors using physical locking mechanisms; thus eliminating the need for adhesives and so enabling reusability without mechanical failure. These 3D printed plugs and ports are demonstrated by the synthesis of gold nanoparticles (AuNPs) in a HEPES-mediated microfluidic system under different flow rate ratios …

“From Compression To Closure: Efficacy And Safety Of Vascular Closure Devices (Vcd) Versus Manual Compression: A Comparative Analysis Of Hemostatic Strategies Of Obtura, Angioseal, And Proglide Vcd“, Praveen Shukla, Kumar Himanshu, Ali Mohammed, Mukesh Jitendra Jha, Santosh Kumar Sinha, Puneet Aggarwal, Mohammad Mahmodullah Razi, Mohit Sachan, Awadhesh Kumar Sharma, Umeshwar Pandey, Neeraj Prakash, Rakesh Kumar Verma

Journal of the Saudi Heart Association

Objective: Use of vascular closure devices (VCDs) for femoral artery puncture site hemostasis has increased but their safety and efficacy have remained unclear. This study was designed to compare safety and efficacy of Obtura, Angioseal, and Proglide VCD to manual compression (MC) and also between for femoral artery haemostasis.

Methods:This was prospective, randomized controlled study where patients were randomly assigned on 1:1:1:1 basis. Primary endpoints were time to hemostasis (TTH) and ambulation time (AT) while secondary endpoints were deployment success, device related adverse events and technical success rate. ANOVA and Tukey HSD was conducted to draw significant difference between …

Reconstruction In Philosophy Of Mathematics, Davide Rizza

Dewey Studies

No abstract provided.

The Serious Business Of Play: Finding Connection, Meaning, And Sometimes Joy, Sasha Barab, Alan Gershenfeld

Creative Nonfiction Magazine

No abstract provided.

Pragmatism In Transition, Michael G. Festl

Dewey Studies

No abstract provided.

John Dewey's Pragmatic Philosophy As A Critique Of Economic Discourse, Maciej Kassner

Dewey Studies

No abstract provided.

Field Philosophy: Deweyan Inquiry On Climate Change Adaptation Perspectives, Anthony Voisard

Dewey Studies

No abstract provided.

Slipping Away, Sue Fagalde Lick

Creative Nonfiction Magazine

No abstract provided.

5 Tips For Great Sex (Writing), Suzanne Roberts

Creative Nonfiction Magazine

No abstract provided.

He Was My First, Too, Roger Tolle

Creative Nonfiction Magazine

No abstract provided.

Recollections Of A Fly Sex Therapist, Natalie Van Hoose

Creative Nonfiction Magazine

No abstract provided.

Secret Museums, B. Pietras

Creative Nonfiction Magazine

No abstract provided.

When They Start Asking Questions, Steph Auteri

Creative Nonfiction Magazine

No abstract provided.

A Kink In The Tale: On Libido And The Writing Practice, Nicola Waldron

Creative Nonfiction Magazine

No abstract provided.

Visits To The Border, Susan V. Meyers

Creative Nonfiction Magazine

No abstract provided.

Yellow, Maureen Hirthler

Creative Nonfiction Magazine

No abstract provided.

The Cherry Birds, Kateri Kosek

Creative Nonfiction Magazine

No abstract provided.

What We Don't Talk About When We Talk About Drinking, Beth Kracklauer

Creative Nonfiction Magazine

No abstract provided.

Mahmoud V. Taylor: A Significant Victory For The Religious Rights Of Parents With Children In Public Schools, Rena M. Lindevaldsen

Liberty University Law Review

The Supreme Court’s June 2025 decision in Mahmoud v. Taylor unmistakably accomplished two things: it strengthened the Free Exercise Clause protections of the First Amendment, and it weakened the ability of schools to press an ideological agenda on matters of human sexuality and gender identity when the materials substantially interfere with the religious development of children. After Montgomery County refused to exercise its discretion to give parents notice and the right to opt their elementary-aged children out of objectional material concerning gender identity and sexual orientation, several parents and a non-profit organization sued, alleging free exercise and parental rights claims. …

Master Class, Shannon Reed

Creative Nonfiction Magazine

No abstract provided.

Bottomless, Jefferson Slagle

Creative Nonfiction Magazine

No abstract provided.

You Don't Have To Be Here, Anne P. Beatty

Creative Nonfiction Magazine

No abstract provided.

Faith Healing, Kelly Beard

Creative Nonfiction Magazine

No abstract provided.

The Diving Well, Sarah Kasbeer

Creative Nonfiction Magazine

No abstract provided.

From The Editor: What's The Story?, Lee Gutkind

Creative Nonfiction Magazine

No abstract provided.

Relevé: To Rise, Victoria Sottosanti

Creative Nonfiction Magazine

No abstract provided.