Digital Commons Network^™

Pharmacodynamics, Efficacy, And Safety Of Intraputaminal Eladocagene Exuparvovec Administered To Pediatric Patients With Aromatic L-Amino Acid Decarboxylase Deficiency Using An Mr-Compatible Cannula: 48 Weeks Of Follow-Up, Daniel J Curry, Phillip L Pearl, Scellig S D Stone, Donald L Gilbert, Sudhakar Vadivelu, Bruria Ben-Zeev, Matthew Vestal, Muhammad Zafar, Chun-Hwei Tai, Sheng-Che Chou, Zion Zibly, Lior Ungar, Mered Parnes, Mariam Hull, Lisa Emrick, Christian Werner, Alexis Krolick, Vinay Penematsa, Antonia Wang, Rezwanur Rahman, Lee Golden, Yin-Hsiu Chien, Paul Wuh-Liang Hwu

Faculty, Staff and Students Publications

Aromatic ʟ‐amino acid decarboxylase (AADC) deficiency is a rare pediatric neurotransmitter disorder that typically necessitates lifelong care, and that carries a risk of childhood mortality. Eladocagene exuparvovec gene therapy is designed to restore AADC production. Study GT‐002 (NCT04903288) is a phase 2, multicenter, open‐label trial assessing the pharmacodynamics, safety, and efficacy of eladocagene exuparvovec administered to the putamen bilaterally in pediatric patients with AADC deficiency using a magnetic resonance (MR)‐compatible cannula. Patients received eladocagene exuparvovec at 1.8 × 1011 vector genomes via the SmartFlow MR‐compatible cannula in a single operative session. Endpoints include the change from baseline in …

External Validation Of Calculator For Cesarean Delivery During Induction Of Labor, Claudia J Ibarra, Rachel L Wiley, Han-Yang Chen, Estefania Guthrie, Ipsita Ghose, Hector Mendez-Figueroa, Suneet P Chauhan

Faculty, Staff and Students Publications

Objective: To validate a published risk calculator to predict cesarean delivery (CD) among singletons undergoing induction of labor.

Methods: Our retrospective cohort study included singletons undergoing induction of labor. A predicted CD score was calculated for each individual based on a previously developed calculator. External validation of the calculator was assessed by the discriminative power of the model by using the area under the receiver operating characteristic curve, and by a calibration curve. The score was categorized as less than 10%, 10% to less than 30%, and 30% or greater. The primary outcome was CD. The secondary outcomes were a …

Examining Sleep-Related Problems In Youth With Misophonia, Kevin M Wagner, Matti Cervin, Catherine E Rast, Mered Parnes, Nicholas Murphy, Samuel Spencer, Eric A Storch, Andrew G Guzick

Faculty, Staff and Students Publications

The relationship between misophonia and sleep-related problems (SRPs) in youth is underexplored. This paucity of research is concerning because SRPs might be elevated among youth with misophonia. If left untreated, SRPs can contribute to long-term health consequences. Thus, in this study we examined the link between misophonia and SRPs in youth aged 8 to 17. In this study, we compared SRPs in 102 children and adolescents with clinically significant misophonia to SRPs in a normative youth sample and a sample of 94 youth with anxiety disorders. We also examined the extent to which SRPs were associated with misophonia severity. Approximately …

Concurrent Vulvar Vitiligo And Lichen Sclerosus: The Importance Of Melanocyte-Specific Immunostains In Resolving Diagnostic Ambiguity, Nabor S Mireles, Kaitlyn Levett, Annie Dai, Abdul Hafeez Diwan, Omid Jalali

Faculty, Staff and Students Publications

Vitiligo and lichen sclerosus (LS) are autoimmune dermatoses that may share overlapping clinical and histopathologic features, posing diagnostic challenges when they occur concurrently. We report a biopsy-confirmed case of vulvar vitiligo and LS in a 61-year-old woman presenting with pruritic, depigmented patches on the labia majora and minora. Histopathologic examination showed epidermal thinning with papillary dermal hyalinization and a dense, band-like lymphocytic infiltrate consistent with LS. Melan-A immunostaining demonstrated a complete absence of epidermal melanocytes, confirming concurrent vitiligo rather than LS-related post-inflammatory hypopigmentation. This case underscores the importance of correlating subtle clinical clues with melanocyte-specific immunostains to distinguish coexistent vitiligo …

Simulation Culture And Organizational Readiness In Social Work Education: Examining Faculty Perspectives., Kate Whitney

Doctor of Social Work Capstone Projects

Despite the growing emphasis on simulation-based learning (SBL), faculty perceptions of organizational readiness for this approach in social work education remain understudied. This exploratory mixed-methods study examined faculty readiness across two CSWE-accredited programs using the Simulation Culture Organizational Readiness Scale (SCORS) and qualitative open-ended questions (𝑁=21). Findings revealed modest and uneven readiness across both programs, with full-time faculty reporting significantly lower readiness scores than adjunct and part-time faculty. Qualitative data identified critical needs for foundational dialogue on SBL principles, strategic institutional investment, and targeted faculty development. Participants also expressed concerns regarding the pace of adoption and potential conflicts with the …

Substance Use Stigma: Examining The Role Of Social Work Education., Eboni Burton

Doctor of Social Work Capstone Projects

This study explored the extent of substance use related stigma among social work students and professionals (i.e., BSW, MSW, PHD and DSW) and its relationship to specialized education/training in substance use and professional practice with people who use drugs (PWUD)/live with a substance use disorder (PWSUD). Stigma was measured using the Opening Minds Provider Attitudes Toward Opioid Use Scale and the Medical Condition Regard Scale. The final sample size was 263. Results indicate that current enrollment in a social work program, post degree or non-curriculum related substance use related training, and personal and professional experience with substance use specifically, mitigate …

Emergency Department Boarding For Psychiatric Care: The Effect Of Pointclickcare Integration., Chris Rowan

Doctor of Social Work Capstone Projects

Emergency Department Boarding for Psychiatric Care: The Effect of PointClickCare Integration

Abstract

For many individuals in psychiatric crisis, the emergency department has become the first place to seek help, highlighting gaps in how behavioral health care is accessed and coordinated. In Massachusetts, PointClickCare's Behavioral Health Treatment and Referral Platform (BH TRP) was implemented to centralize and streamline referrals between emergency departments and inpatient psychiatric facilities. This capstone evaluates whether implementation of the BH TRP was associated with changes in psychiatric boarding time at a community hospital emergency department. Using a mixed-methods program evaluation design, this study analyzed de-identified electronic medical …

The Unexplored Relationship Between Adverse Childhood Experiences, Burnout, And Resiliency Among Hospital Staff., Elizabeth Davis

Doctor of Social Work Capstone Projects

This study addresses the critical issue of staff turnover at Baptist Health Floyd, where rates exceed national hospital averages. While prior research connects burnout to workplace stressors, less is known about the role of adverse childhood experiences (ACEs) and resilience among hospital staff. Understanding these relationships is essential for improving workforce stability and patient care outcomes. A cross-sectional survey design was used, with convenience sampling of hospital employees and providers (n=207). Data were collected via a Qualtrics survey using validated instruments: the Maslach Burnout Inventory (Maslach et al., 2016), the ACE questionnaire (Felitti et al., 1998), and the Brief Resilience …

Submission To The Decadal Plan For Australian Education Research Consultation Paper, Australian Council For Educational Research (Acer)

Shaping educational policy

This submission to the Decadal Plan for Australian Education Research Consultation Paper recognises a critical role for education research is to equip educators, leaders and systems with robust information, tools and practices to confidently inform decision-making about teaching, learning, and leadership. The submission highglights the importance of First Nations-led research, and an inclusion mindset for education research and AI as a tool for learning as key to justice, quality and equity for all. ACER understands that the field of education is highly interconnected and draws on evidence from multiple disciplines; it follows that collaboration in education research is the key …

A Critical Review Of Statistical, Signal Processing And Machine Learning Methods For Continuous And High-Frequency Water Quality Data Improvement, A.T. Badrudeen, D. Sahoo, Calvin Sawyer, Jeremy Pike, R.D. Haramel

Publications

In the digital water world, high-frequency water quality monitoring from sensors is crucial for capturing rapid changes, especially during storm events or discharge fluctuations, in which important signals can occur at sub-hourly intervals. These signals are represented in a time series and can sometimes be irregular, noisy, and prone to missing values or errors due to buried conditions, sediment interference, and signal loss. The fine resolution of reporting also increases the risk of sensor errors and data loss, necessitating effective correction methods to ensure the accuracy and usability of the data. This literature review investigates the current state of time …

Enterprise Digital Transformation: An Analysis Of Value Creation From An Operational Perspective, Weiguo Ling

Dissertations and Theses Collection (Open Access)

Digital transformation has become a critical pathway for the manufacturing sector to break through growth bottlenecks and reshape its core competitiveness. However, in practice, a large number of enterprises are trapped in the transformation paradox of a “discrepancy between perceived consensus and actual outcomes”. The core issue lies in the fact that traditional investment evaluation methods struggle to effectively measure the multi-dimensional value created by digitalization. From the perspective of operational management, this study focuses on the mechanisms and evaluation methods of digital value creation in different manufacturing contexts. A four-dimensional Value Evaluation Framework is proposed, comprise of Value Identification, …

The Impact Of Service Model Innovation Of Woodworking Machinery Equipment Suppliers On Downstream Furniture Industry Enterprises' Competitiveness, Wenquan Jing

Dissertations and Theses Collection (Open Access)

This study examines the impact of service model innovation by woodworking machinery equipment suppliers on the competitiveness of downstream furniture enterprises, focusing on evolving competitive dynamics in equipment manufacturing within the context of service-oriented manufacturing and digital transformation. In the digital economy era, industrial competition is transitioning from traditional product-centric approaches to a value co-creation-oriented paradigm centered on customer value and service capabilities. As a typical equipment manufacturing subsector, the woodworking machinery industry has long relied on equipment sales and after-sales maintenance models that fail to meet downstream furniture enterprises" demands for flexible production, intelligent operation and maintenance, and end-to-end …

The Impact Of Civic Engagement On Filipino Youth During The Pandemic: The Role Of Social Networking Sites For Social Capital Building, Ma. Glenda Wui, Katrina Yuzon, Joane Denise Alliah Axibal, Gel Christian Llames, Enrique Niño P. Leviste

Journal of Youth Development

This study examined the civic engagement of Filipino youth (N=14) volunteers during the COVID-19 pandemic. Anchored in the asset-based framework of Positive Youth Development, the study discussed the critical role of civic engagement in enhancing the well-being of youth during the pandemic. It also analyzed the role of Social Networking Sites (SNS) in building social capital for civic engagement. Through in-depth interviews, the study examined the impact of the participants’ engagement on their lives, and how they confronted challenges related to civic work. Thematic analysis of the interview data yielded four themes: personal challenges during the pandemic, coping with the …

Improving Agent Retention By Documenting The Impact Of 4-H In Kentucky, Ken Culp, Kimberly Ragland, Tori Stanton, Katherine L. Thompson

Journal of Youth Development

The purpose of this study was to improve agent retention by documenting the positive impact that 4-H agents were making by identifying the most effective program delivery methods in Kentucky. This could help agents prioritize their time, emphasizing high-impact activities. Agents indicated that while one year of 4-H makes the greatest impact, 10 years’ membership is ideal. The most impactful delivery methods were clubs and camps. The most important life skills developed in 4-H were communication, leadership, and community service. Club programming includes all highly valued core experiences identified in this study (leadership opportunities, community service, and communication).

Community-Based Programming And Ecological Resilience In Vulnerable Youth: A Mixed Methods Study, Alicia Mcvarnock, Leanna M. Closson, Meg Ternes, Nichole L. Cole

Journal of Youth Development

This exploratory sequential mixed-methods study aimed to provide a deeper understanding regarding ecological resilience theory among adolescents and emerging adults engaged in community-based programming. Phase 1 participants were 18 Leave Out Violence Nova Scotia Youth Leaders and alumni aged 16 to 31 (M_age = 24.28, SD = 3.75; n = 10 female). Semi-structured interviews were used to examine participants’ past and present experiences with Leave Out Violence Nova Scotia, with a focus on perceptions of resilience in their lives. Results were analyzed through mixed (inductive and deductive) thematic analysis. In Phase 2, a focus group assisted in developing a …

Love, Support, Good Vibes: Unconditional Positive Regard And Lgbtqia+ Youth After-School Stories, M V. Pease, Maggie Brooks, Wilson Lazo-Salmeron, Ayushi Sarkar, Halle Ho-Yee Shen, Sharon Colvin

Journal of Youth Development

LGBTQIA+ youth face high rates of identity rejection and bullying, creating an urgent need for support and affirmation within oppressive societal structures. School environments can uniquely support LGBTQIA+ youth through after-school programming designed to provide positive community experiences. Using qualitative thematic analysis of personal stories from LGBTQIA+ youth (N=94), we examined what LGBTQIA+ youth envision as ideal support within after-school programming. Our analyses, informed by humanistic psychology principles, revealed eight major themes: good vibes, compassion and empathy, non-judgment and acceptance, multidimensional human connection, safety, proxy for home/family, adults and mentors, and altruism. Results indicate the need for warmth, safety, connection, …

From “Scared” To “Empowered”: Lived Experience Of Out-Of-School Youth In The Philippines, Sheilalaine G. Romulo

Journal of Youth Development

In the Philippines, marginalized youth (e.g. out-of-school) are mostly excluded from civic engagement. This study explores how 5 young Filipino leaders, once out-of-school, navigated a community-based alliance with adults. The lifeworld of these young leaders is accessed through a phenomenological interview guided by Max van Manen’s phenomenological method. Their lived experience tells a transformative journey of being scared youth to becoming empowered young leaders who have found their voice after overcoming insecurities, fear of exclusion, and being misunderstood. It can also be gleaned from their lived experience how the adult partners may have contributed to their transformation. This article recommends …

Growing Mathletes: Integrating Growth Mindset, Math, And Sports To Support Youth Learning, Sanlyn Buxner, Erin Turner, Seneca B. Miller, Christina Baze, Ricardo Valerdi

Journal of Youth Development

Through Growing Mathletes, we developed and field-tested informal education activities designed to teach math within the context of baseball in a way that supports youth in developing a growth mindset. We present our development strategy and discuss our implementation with third through eighth graders at five informal learning sites across the United States. Assessment of program success included pre- and post-program surveys and post-program interviews with youth from all five informal education settings. Our findings revealed our strategy to integrate growth mindset concepts with math and baseball lessons led to positive outcomes related to youth mindset and confidence. We present …

Scoping Review: Facilitators, Barriers, And Cultural Adaptations In The Caregiver Skills Training Program For Children With Developmental Concerns, Cecilia Montiel-Nava, Maria C. Montenegro, Ana C. Ramirez, Victoria Villarreal, Lucia Murillo Chacko, Pamela Dixon, Sarah Dababnah

Psychological Science Faculty Publications

Autism interventions are predominantly developed in high-income countries, limiting access for families in low- and middle-income countries due to systemic, cultural, and logistical barriers. The Caregiver Skills Training program aims to address this disparity by equipping caregivers with practical skills. This scoping review examines the cultural adaptations, facilitators, and barriers to the implementation of Caregiver Skills Training, focusing on its accessibility, feasibility, and acceptability. A comprehensive search of ERIC, PsycINFO, PubMed, and Web of Science identified eligible studies that reported cultural or linguistic adaptations of Caregiver Skills Training. Forward searches and manual reference checks supplemented the review. Data were extracted …

Trauma: Blunt Solid Organ Injury, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Student Mental Health: Screening For Stress, Anxiety And Depression Using Fitbit Data, Rebecca Lopez, Avantika Shrestha, Ml Tlachac, Kevin Hickey, Xingting Guo, Shichao Liu, Elke Rundensteiner

Information Systems and Analytics Department Faculty Conference Proceedings

College students experience many stressors, resulting in high levels of anxiety and depression. Wearable technology provides unobtrusive sensor data that can be used for the early detection of mental illness. However, current research is limited concerning the variety of psychological instruments administered, physiological modalities, and time series parameters. In this research, we collect the Student Mental and Environmental Health (StudentMEH) Fitbit dataset from students at our institution during the pandemic. We assess the ability of predictive machine learning models to screen for depression, anxiety, and stress using different Fitbit modalities. Our findings indicate potential in physiological modalities such as heart …

How Agile Became The Design Philosophy Of Ai Fishbowl Under Real-World Constraints, Jad Saad

University Honors Theses

This capstone review examines the development of AI Fishbowl, a public-facing, interactive artificial intelligence system, as a case study in how Agile methods evolve from a project management tool into a design philosophy under real-world constraints. Although the project adopted an Agile workflow early on through a Kanban-style task management approach, the initial system design and architecture were still shaped by a largely plan-first mindset. This created a mismatch between flexible process and rigid design assumptions, which became increasingly apparent as the team moved from high-level architecture into implementation.

A critical turning point occurred when early architectural plans proved difficult …

Ce Spotlight: New Dentists! Check Out These Great Annual Session Courses, David Foe

The Journal of the Michigan Dental Association

This source highlights continuing education opportunities specifically recommended for new dentists at the upcoming Michigan Dental Association (MDA) Annual Session in Grand Rapids. It lists a variety of course titles covering clinical techniques, leadership, practice ownership, and personal wellness. Additionally, it provides information on how to access a full listing of MDA CE courses, including on-demand webinars and radiography training, through the official website.

Transfer Learning Neural Networks For Nuclear Forensic Image Morphology Using Image Splitting Techniques, Niko A. Petrocelli, Lee C. Lambert, Brett J. Borghetti, Abigail A. Bickley

Faculty Publications

Manual morphological analysis of actinide particles from scanning electron microscope (SEM) imagery is a critical component of nuclear forensics but is prone to significant inter-analyst variability. To address this challenge, this work develops and evaluates an automated classification method using deep learning. We introduce a methodology based on partitioning 1906 SEM images, representing 13 classes of uranium compounds, into smaller patches for analysis. Three convolutional neural network (CNN) architectures of increasing complexity were compared: a custom baseline CNN, a simple transfer learning model using ResNet50v1, and a complex model featuring hierarchical feature extraction and a spatial attention mechanism built upon …

Design And Development Of A 12-Degree-Of-Freedom Quadruped Robot, Kai De La Cruz

Master's Theses

This thesis presents the design, analysis, and experimental validation of a 12-degree-of-freedom (DOF) quadruped robot developed as a research platform for legged locomotion and control. The system builds upon the Cal Poly Legged Robotics Group’s prior 8-DOF quadruped, addressing key limitations in manipulability, load distribution, and mechanical robustness by introducing a 3-DOF leg architecture.

The mechanical design emphasizes lightweight construction, structural integrity, and modularity to support future research extensions. Static and dynamic loading models were developed to inform component sizing and material selection. A carbon-fiber chassis and redesigned leg assemblies were fabricated and validated through finite element analysis and physical …

The Application, Construction, And Validation Of Hidden Markov Model Profiles For Carbonic Anhydrase Enzymes, Samuel F. Kaplan

Master's Theses

Carbonic anhydrases (CAs) catalyze the reversible hydration of CO2 and have evolved independently at least eight times, resulting in structurally distinct enzyme families (α, β, γ, δ, ζ, η, θ, ι). Traditional sequence alignment methods struggle to classify these convergently evolved proteins because their sequential similarity does not reliably indicate functional or evolutionary relationships. Many CA sequences in public databases are annotated generically without family assignments, and prior computational approaches have focused predominantly on the three well characterized families (α, β, γ), leaving the five recently discovered classes without robust classification tools. Family level assignment is often a prerequisite for …

Sea Level Trends Near Critical Levees In The Sacramento-San Joaquin Delta, Reyna Sanchez Gomez

Master's Theses

The Sacramento-San Joaquin Delta (Delta) levee system faces threats from rising sea levels, land subsidence, and deteriorating levees, all of which pose risks to California’s primary surface water supply. The purpose of this thesis is to assess relative sea level rise (RSLR) and estimate the spatially varying factors that influence water levels in the Delta. This thesis extends the work of Baranes et al. (2023) to the period 1975-2022 by appending recently acquired water-level records (1975-1982) to modern datasets (1982-2022) from 10 water-level stations. These water level datasets were digitized, quality-assured, and referenced to a common geodetic datum, as described …

Measurement And Control Of The Oxidation-Reduction Potential And Its Chemical And Sensory Consequences In Wines, William Jordan Wright

Master's Theses

The oxidation-reduction potential (ORP) is a measurement thought to reflect the overall ability of a solution to oxidize or reduce substances within that solution. In wine, there is no absolute agreement as to which substances control or dominate the ORP; however, oxygen, ethanol, iron-tartrate and copper-tartrate complexes, and glutathione are suspected to play key roles, while sulfur dioxide and phenolics may act as buffers. Anecdotally, some varieties of Vitis vinifera are prone to oxidation while others are prone to reduction, though the chemical basis of this remains unclear. The following works aim to further elucidate the influence of specific chemical …

Designing For Trust In Chat-Based Question Answering Systems: An Exchange-Based Retrieval Approach, Nathan Mccutchen

Master's Theses

Community chat platforms such as Discord and Slack support spontaneous, collaborative communication but make it difficult to retrieve previously discussed information. As conversations accumulate, valuable exchanges become buried, leading to repeated questions and sustained burden on experienced community members.

This work contributes a set of design requirements for question-answering systems operating over unstructured chat data, a Discord bot prototype implementing those requirements named Echo, and an empirical evaluation of how such a system affects user trust. Rather than encoding discrete question-answer pairs or generating synthetic responses with a language model, Echo indexes conversation topics for semantic retrieval and presents results …

Associations Between Nutrition-Related Chronic Disease And Food Insecurity: Data From The California State University, Elizabeth Ochoa

Master's Theses

Food insecurity is a growing public health concern consistently associated with elevated rates of nutrition-related chronic disease (NRCD) across the general population. Despite young adulthood being a critical window for dietary pattern formation, this relationship remains minimally explored among college students. This thesis examined associations between food insecurity and NRCD diagnosis, including hypertension, diabetes, hyperlipidemia, and cardiovascular disease, among undergraduate students across the California State University (CSU) system. Cross-sectional data were drawn from the Spring 2021 CSU National College Health Assessment, administered across all 23 campuses. After exclusions, the analytical sample comprised 13,762 students. Bivariate analyses assessed relationships between key …