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Communicating Through A Crisis: An Analysis Of The University Of Mississippi's Initial Covid-19 Crisis Communications, Sydney Waitley May 2022

Communicating Through A Crisis: An Analysis Of The University Of Mississippi's Initial Covid-19 Crisis Communications, Sydney Waitley

Honors Theses

This thesis, in effort to examine modern-day crisis communications, focuses on the analysis of University of Mississippi’s initial crisis communications during the COVID-19 pandemic during March 2020. The purpose of this research was to evaluate the university’s communication efforts during this crisis in order to determine the effectiveness of the University of Mississippi’s initial COVID-19 crisis communications. First, the researcher analyzed historical case studies on three notable crisis communications (the Johnson & Johnson Tylenol Crisis of 1982, the United Airlines Crisis of 2017, and the Crock-Pot Crisis of 2018). From these case studies, qualities of good crisis communications were determined …


The American Prosecutor And The Carceral State: An Analysis To Address Prosecutorial Power And Discretion In An Effort To Reduce Overincarceration In The United States, Olivia Jordan May 2022

The American Prosecutor And The Carceral State: An Analysis To Address Prosecutorial Power And Discretion In An Effort To Reduce Overincarceration In The United States, Olivia Jordan

Honors Theses

There is perhaps no other actor within our legal system that shares more power and control over the carceral state than the American prosecutor. This thesis examines the powers of the prosecutor at every stage of criminal procedure, how these powers contribute to the carceral state, and how prioritizing prosecutorial policy reform can effectively reduce persistent mass incarceration in the United States. This thesis uses three criteria- effectiveness at reducing overincarceration, feasibility of implementation, and ethical impact- to critically evaluate several proposals for addressing prosecutorial power and discretion. Ultimately, the thesis recommends a combination of three proposals for a more …


Dotphotozine, Issue 11, 2022, Students Of The Csusb Art Department, Thomas Mcgovern May 2022

Dotphotozine, Issue 11, 2022, Students Of The Csusb Art Department, Thomas Mcgovern

Dotphotozine

No abstract provided.


Absence Of Neutralizing Antibody Formation During Incobotulinumtoxina Treatement Of Spasticity In Botulinum Toxin-Naive Children With Cerebral Palsy: Pooled Analysis Of Three Phase 3 Studies, Henry Chambers, Petr Kanovsky, A Sebastian Schroeder, Edward Dabrowski, Thorin Geister, Angelika Hanschmann, Irena Pulte, Michael Althaus, Marta Banach, Deborah Gaebler-Spira, Florian Heinen May 2022

Absence Of Neutralizing Antibody Formation During Incobotulinumtoxina Treatement Of Spasticity In Botulinum Toxin-Naive Children With Cerebral Palsy: Pooled Analysis Of Three Phase 3 Studies, Henry Chambers, Petr Kanovsky, A Sebastian Schroeder, Edward Dabrowski, Thorin Geister, Angelika Hanschmann, Irena Pulte, Michael Althaus, Marta Banach, Deborah Gaebler-Spira, Florian Heinen

Conference Presentation Abstracts

Introduction: The development of neutralizing antibodies (NAbs) has been linked to secondary non-response to botulinum neurotoxin type A (BoNT-A) injections. This may be of special concern when treating conditions like pediatric spasticity. We investigated NAb formation in three large Phase 3 studies with incobotulinumtoxinA, a BoNT-A lacking complexing proteins, in children/adolescents with cerebral palsy (CP).

Patients and methods: Patients with lower-limb (LL), upper-limb (UL), or combined LL/UL spasticity (2–17 years; uni- or bilateral CP; Ashworth Scale score ≥2 in clinical patterns for treatment) received total body weight incobotulinumtoxinA ≤16–20 U/kg (max. 400–500 U) depending on the study (TIM: NCT01893411; TIMO: …


An Integrated Preaching Design : A Methodological Framework For Preaching In The Indian Context, Ancy John May 2022

An Integrated Preaching Design : A Methodological Framework For Preaching In The Indian Context, Ancy John

ATS Dissertations

No abstract provided.


Social Determinants And Comorbidities In Non-Pharmacological Interventions For Chronic Pain In Community- Dwelling Older Adults: A Scoping Review Of Randomized Controlled Trials, Anitha Saravanan, L Reagan, R Rivera, N Challa, H Lankipalle, Vrr Sareddy, A Starkweather May 2022

Social Determinants And Comorbidities In Non-Pharmacological Interventions For Chronic Pain In Community- Dwelling Older Adults: A Scoping Review Of Randomized Controlled Trials, Anitha Saravanan, L Reagan, R Rivera, N Challa, H Lankipalle, Vrr Sareddy, A Starkweather

Faculty Articles, Papers, and Other Scholarship

Background: Chronic pain frequently exists with other comorbid conditions in older adults, yet little is known about the effectiveness of non-pharmacologic interventions. A scoping review was conducted to provide an overview of the nature of the published evidence on the nonpharmacological interventions for chronic pain in community dwelling older adults with comorbid conditions.

Methods: A literature search of relevant databases was conducted using PRISMA guidelines. Studies were included if they were intervention studies, used a randomized controlled trial design, and met criteria of the critical appraisal.

Results: Eleven studies were identified as high quality. Most studies did not quantify a …


Home/Sick, Elizabeth P. Fontenot May 2022

Home/Sick, Elizabeth P. Fontenot

Electronic Theses and Dissertations

This paper is a supporting document that discusses the conceptual and technical aspects of the artworks in the accompanying exhibition, HOME/SICK. The work in the exhibition consists of selections from different series of work that are inspired by related subject matter. The content driving the work responds to anecdotal experiences of people living in communities near oil refineries and chemical processing plants and how events at these facilities affect their way of life. Many times, these are communities of color which strive to voice concerns and protect homes from harmful toxins. In one series, original and appropriated imagery serves as …


Fish Community Assembly At Multiple Spatial Scales In East Texas Streams, Jake R. Swanson May 2022

Fish Community Assembly At Multiple Spatial Scales In East Texas Streams, Jake R. Swanson

Electronic Theses and Dissertations

Stream communities are structured by environmental processes that vary in strength across different spatiotemporal scales. Therefore, revealing how stream fish communities are influenced by environmental gradients may clarify how communities respond to disturbance associated with anthropogenic change. I investigated the relative role environmental variables play in the processes that structure the taxonomic and functional diversity of stream fish communities, as well as historical trends in occurrence and local habitat associated with a species of greatest conservation need within east Texas. The results of this study indicate that stream sites with more habitat complexity and stability support a more taxonomically and …


Improvements In Upper Limb Spasticity-Related Pain In Children/Adolescents With Cerebral Palsy After Incobotulinumtoxina Injections, Florian Heinen, Michaela Bonfert, Petr Kanovsky, A Sebastian Schroeder, Henry Chambers, Edward Dabrowski, Thorin Geister, Angelika Hanschmann, Michael Althaus, Marta Banach, Deborah Gaebler-Spira May 2022

Improvements In Upper Limb Spasticity-Related Pain In Children/Adolescents With Cerebral Palsy After Incobotulinumtoxina Injections, Florian Heinen, Michaela Bonfert, Petr Kanovsky, A Sebastian Schroeder, Henry Chambers, Edward Dabrowski, Thorin Geister, Angelika Hanschmann, Michael Althaus, Marta Banach, Deborah Gaebler-Spira

Conference Presentation Abstracts

Introduction: The effects of incobotulinumtoxinA on upper limb (UL) spasticity-related pain (SRP) over multiple treatment cycles (ICs) in children/adolescents (C/As) with cerebral palsy (CP) were analyzed using pooled data from two prospective phase 3 trials.

Patients and methods: C/As aged 2–17 years with CP-associated UL spasticity received incobotulinumtoxinA for 4 ICs. SRP was assessed with the Questionnaire on Pain caused by Spasticity (QPS) using C/A- (direct or via interviewer) and parent/caregiver (P/C)-completed UL modules. The pain population included all C/As with a key QPS item score >0 at baseline; post-baseline scores of 0 indicated complete pain relief.

Results: Data from …


Improvements In Lower Limb Spasticity-Related Pain In Children/Adolescents With Cerebral Palsy After Incobotulinumtoxina Injections, Florian Heinen, Michaela Bonfert, Petr Kanovsky, A Sebastian Schroeder, Henry Chambers, Edward Dabrowski, Thorin Geister, Angelika Hanschmann, Michael Althaus, Marta Banach, Deborah Gaebler-Spira May 2022

Improvements In Lower Limb Spasticity-Related Pain In Children/Adolescents With Cerebral Palsy After Incobotulinumtoxina Injections, Florian Heinen, Michaela Bonfert, Petr Kanovsky, A Sebastian Schroeder, Henry Chambers, Edward Dabrowski, Thorin Geister, Angelika Hanschmann, Michael Althaus, Marta Banach, Deborah Gaebler-Spira

Conference Presentation Abstracts

Introduction: The effects of incobotulinumtoxinA on lower limb (LL) spasticity-related pain (SRP) over multiple treatment cycles (ICs) in children/adolescents (C/As) with cerebral palsy (CP) were analyzed using pooled data from three prospective phase 3 trials.

Patients and methods: C/As aged 2–17 years with CP-associated LL spasticity received incobotulinumtoxinA for 4 ICs. SRP was assessed with the Questionnaire on Pain caused by Spasticity (QPS) using C/A- (direct or via interviewer) and parent/caregiver (P/C)-completed LL modules. The pain population included all C/As with a key QPS item score >0 at baseline; post-baseline scores of 0 indicated complete pain relief.

Results: Data from …


Prevalence Of Spasticity-Related Pain In Children/Adolescents With Cerebral Palsy, Florian Heinen, Michaela Bonfert, Petr Kanovsky, A Sebastian Schroeder, Henry Chambers, Edward Dabrowski, Thorin Geister, Angelika Hanschmann, Michael Althaus, Marta Banach, Deborah Gaebler-Spira May 2022

Prevalence Of Spasticity-Related Pain In Children/Adolescents With Cerebral Palsy, Florian Heinen, Michaela Bonfert, Petr Kanovsky, A Sebastian Schroeder, Henry Chambers, Edward Dabrowski, Thorin Geister, Angelika Hanschmann, Michael Althaus, Marta Banach, Deborah Gaebler-Spira

Conference Presentation Abstracts

Introduction: This analysis determined the prevalence and intensity of spasticity-related pain (SRP) in children/adolescents (C/As) with cerebral palsy (CP).

Patients and methods: Baseline data from the prospective incobotulinumtoxinA trials TIM, TIMO and XARA were pooled. In all three studies, SRP was assessed in C/As aged 2–17 years with lower limb (LL) and/or upper limb (UL) spasticity using the Questionnaire on Pain caused by Spasticity (QPS); both self-reports (direct or via interviewer) and parent/caregiver (P/C) observer reports were included. A C/A was considered to have SRP if any QPS key item score was rated >0 at baseline. Individual QPS modules were …


Authoring Prior Art, Joseph P. Fishman, Kristelia Garcia May 2022

Authoring Prior Art, Joseph P. Fishman, Kristelia Garcia

Vanderbilt Law Review

Patent law and copyright law are widely understood to diverge in how they approach prior art, the universe of information that already existed before a particular innovation's development. For patents, prior art is paramount. An invention can't be patented unless it is both novel and nonobvious when viewed against the backdrop of all the earlier inventions that paved the way. But for copyrights, prior art is supposed to be virtually irrelevant. Black-letter copyright doctrine doesn't care if a creative work happens to resemble its predecessors, only that it isn't actually copied from them. In principle, then, outside of the narrow …


Deliberately Indifferent: Institutional Liability For Further Harassment In Student-On-Student Title Ix Cases, Jacob R. Goodman May 2022

Deliberately Indifferent: Institutional Liability For Further Harassment In Student-On-Student Title Ix Cases, Jacob R. Goodman

Vanderbilt Law Review

Sexual harassment is an unfortunate problem far too many have experienced. Universities and other educational institutions owe a duty, both legal and moral, to protect students from sexual harassment, and in turn to allow students to receive the full benefits of their education. But a circuit split has limited students' ability to hold educational institutions liable. This circuit split results in the absurd scenario where an individual must experience sexual harassment more than one time to hold their educational institution liable. This Note attempts to fix that by proposing Title IX (the law governing sexual harassment at educational institutions) adopt …


Randomized, Clinical Trials On The Effects Of Robotic-Assisted Gait Training For Stroke Subjects: A Scoping Review, Daniel K. Hufnagel May 2022

Randomized, Clinical Trials On The Effects Of Robotic-Assisted Gait Training For Stroke Subjects: A Scoping Review, Daniel K. Hufnagel

University Honors Theses

Robotic-assisted gait training has been cited as a potential rehabilitation intervention for the recovery of ambulation in hemiplegic stroke patients. Previous reviews on robotic gait training have elicited a need for more randomized, clinical studies on robotic gait training for the development of evidence-based intervention protocols and elimination of research bias. The purpose of this scoping review was to provide an updated examination of the clinical research on robotic assisted gait training and address any research gaps to be considered for future research. This review included randomized, clinical trials on stroke patients with a robotic-assisted treatment (RAGT) and conventional gait …


Multi-Trophic Biodiversity Increases With Increasing Structural Complexity Of Forest Canopy, Ayanna St. Rose May 2022

Multi-Trophic Biodiversity Increases With Increasing Structural Complexity Of Forest Canopy, Ayanna St. Rose

Graduate Theses and Dissertations

Understanding the effects of forest canopy structural complexity on multi-trophic diversity is critical for conserving biodiversity and managing land sustainably. But multi-trophic diversity is often ignored when making decisions about land management due to lack of cost- and time-effective methods to evaluate it. Here, we explored a new method based on widely available remote sensing data to quantify canopy structural complexity and its relationships with multi-trophic biodiversity at landscape scale using 32 forested sites of the National Ecological Observatory Network. We investigated the influence of vertical and horizontal structural complexity of forest canopy on multi-trophic (primary producers, herbivores (beetles), omnivores …


Developmental Kindergarten Classroom Intervention For Spatial Relational Terms, Maggie Eising, Courtney Karasinski May 2022

Developmental Kindergarten Classroom Intervention For Spatial Relational Terms, Maggie Eising, Courtney Karasinski

Open Access Publishing Support Funded Articles

Purpose

Relational ability is a key attribute of language. Knowledge of relational terms, including spatial terms, can facilitate development of relational ability. Acquisition of spatial terms can be challenging and necessitates experience and input due to the abstractness of the concepts. Service delivery models for school-based speech-language pathologists (SLPs) are changing from traditional “pull-out” therapy to intervention in the classroom. Response to Intervention (RtI) and multi-tiered system of support (MTSS) frameworks have expanded SLPs’ roles to working with all children at-risk for academic difficulties.

Methods

Given the importance of spatial terms, and the changing roles and service delivery models for …


Pandemic And Post-Pandemic Fashion Consumer And Business Trends, Su Yun Bae May 2022

Pandemic And Post-Pandemic Fashion Consumer And Business Trends, Su Yun Bae

Visions in Leisure and Business

COVID-19 has had an impact on both consumers and businesses. It has shifted consumer preferences to enjoy nature more and be more aware of environmental issues than ever before. Many businesses suffered during the pandemic, but some thrived as consumer lifestyles and needs changed. This article looks at changes in the market and consumer behavior during the COVID-19 crisis as well as consumer and business trends following the epidemic. It primarily focuses on consumer positivity and sustainability, as well as a business emphasis on innovation, human capital, personalized consumer experience, and the importance of positivity, inclusivity, and diversity.


Young Adult Literature: The Past, The Present, And The Person, Kelsea Abston May 2022

Young Adult Literature: The Past, The Present, And The Person, Kelsea Abston

Honors College

During the COVID-19 pandemic, many national and global issues have been brought to light such as the Taliban government takeover in Kabul, the Black Lives Matter movement, and the mental health crisis. By using the following three novels - The Fountains of Silence by Ruta Sepetys, Dear Martin by Nic Stone, and Turtles All the Way Down by John Green - intertwined with literary theories and pre-established research regarding the use of literature to facilitate discussion, this paper intends to show howYoung Adult literature can help readers - teens and adults alike - to understand the weight of such …


Good For The Goose But Not For The Gander: Biden’S Promise To Appoint A Black Female To The Supreme Court And Title Vii Principles, Michael Conklin May 2022

Good For The Goose But Not For The Gander: Biden’S Promise To Appoint A Black Female To The Supreme Court And Title Vii Principles, Michael Conklin

Texas A&M Law Review

The 2022 retirement of Justice Stephen Breyer and President Joe Biden’s promise to exclude all non-Black females from consideration for his replacement has sparked controversy. Some have praised the decision as essential to ensuring diversity on the Court and point out that there are more than enough qualified Black women to select from. And some believe the decision will result in corporate leaders making similar calls for equity in their own companies. Others have criticized the decision, expressing a belief that discriminating on the basis of race and gender is “not a great start in selecting someone sworn to provide …


Development Of Upconverting Films Containing Singlet Sink, Blake Mckay May 2022

Development Of Upconverting Films Containing Singlet Sink, Blake Mckay

Honors Theses

Upconversion is the conversion of light from a longer wavelength to a shorter wavelength. This technique has a wide range of applications in solar technology, bioimaging, drug delivery, and many other fields.1 In this study, a three-part upconverting system was developed including a component termed singlet sink in order to increase upconversion efficiency. The components of this system included Palladium (II) Octaethylporphrin (PdOEP), pyrenebutanol, and 9-phenyl-10-(p-tolylethynyl)-anthracene (PTEA). A procedure was developed in order to create and process films containing these three materials dispersed in a poly(methyl methacrylate) (PMMA) matrix. Upconversion was analyzed in both solution and the …


When The Green In Green Packaging Backfires: Gender Effects And Perceived Masculinity Of Environmentally Friendly Products, Reto Felix, Eva M. González, Raquel Castaño, Lorena Carrete, Richard T. Gretz May 2022

When The Green In Green Packaging Backfires: Gender Effects And Perceived Masculinity Of Environmentally Friendly Products, Reto Felix, Eva M. González, Raquel Castaño, Lorena Carrete, Richard T. Gretz

Marketing Faculty Publications

Previous research has emphasized the importance of product packaging to consumers’ attitudes and purchase intentions, but empirical studies that explore the specific mechanisms by which packaging color influences marketing-relevant downstream variables in relation to environmentally friendly products is scarce. The current research addresses this gap by building on insights from theories on consumption values, gender roles, and gendered products. In two studies, the current research shows (1) how color-induced perceptions of masculinity can trigger perceived product effectiveness and purchase intentions, (2) how competing mediation through masculinity and perceived fit with the product category influences perceived product effectiveness and purchase intentions …


The Happiest Place On Earth: A Grounded Theory Of Fulfillment In Mixed-Orientation Marriages, Isadora Ferreira De Melo May 2022

The Happiest Place On Earth: A Grounded Theory Of Fulfillment In Mixed-Orientation Marriages, Isadora Ferreira De Melo

Electronic Theses and Dissertations

Mixed-orientation marriages (MOMs) are often misunderstood. There is a general cynicism in research literature and in the broader culture regarding the relational viability of same-sex attracted (SSA) individuals who marry someone of the opposite sex. However, there exist couples in MOMs that are resilient and attain satisfaction. The purpose of this study is to better understand how MOMs might become successful. By interviewing maritally satisfied mixed-orientation couples, the Model of Relational Self- Determination in Mixed-Orientation Marriages was developed. This model is separated into five stages that are organized around the experience of disclosure of the SSA spouse’s sexuality. Depending on …


Becoming Stewards Of Attention: A Theological Appeal, Joshua Gorenflo May 2022

Becoming Stewards Of Attention: A Theological Appeal, Joshua Gorenflo

Electronic Theses and Dissertations

The widespread compromising of attention currently taking place in our digital age is, at least in part, a theological issue necessitating a theological response, which invites an examination of the human person in relation to God. Familiar within the biblical narrative and throughout Christian tradition, I suggest that when the role of steward functions as the operative paradigm for humans, the claims made upon their lives have profound implications for attending within the digital age. More specifically, the steward’s attention becomes a tangible expression of authority and accountability in representation of God’s image to the rest of creation. In pursuit …


No Such Thing As A New “Normal”: The Future Of Teaching In A Pandemic World, Victoria Benard May 2022

No Such Thing As A New “Normal”: The Future Of Teaching In A Pandemic World, Victoria Benard

Honors College Theses

Due to the many changes wrought on our society by the COVID-19 pandemic, teachers in high schools have had to dramatically alter their methods of teaching in order to comply with new rules and regulations. These guidelines, deemed safe by the CDC, have completely upended traditional high school classrooms and left teachers scrambling to effectively teach their content and assess student learning. The purpose of this research is to determine the successes and/or failures of high school teachers’ teaching strategies that have undergone dramatic adaptations amidst the COVID-19 pandemic. One goal of this research is to produce a concise understanding …


Sangaku In Multiple Geometries: Examining Japanese Temple Geometry Beyond Euclid, Nathan Hartmann May 2022

Sangaku In Multiple Geometries: Examining Japanese Temple Geometry Beyond Euclid, Nathan Hartmann

Honors College Theses

When the country of Japan was closed from the rest of the world from 1603 until
1867 during the Edo period, the field of mathematics developed in a different way
from how it developed in the rest of the world. One way we see this development
is through the sangaku, the thousands of geometric problems hung in various Shinto and Buddhist temples throughout the country. Written on wooden tablets by people from numerous walks of life, all these problems hold true within Euclidean geometry. During the 1800s, while Japan was still closed, non-Euclidean geometries began to develop across the …


The Lead, May 2022, Lindenwood University May 2022

The Lead, May 2022, Lindenwood University

The Lead

The Lead is an electronic newsletter produced by the Lindenwood College of Education & Human Services.


Ultrasound-Guided Lumbar Medial Branch Blocks And Intra-Articular Facet Joint Injections: A Systematic Review And Meta-Analysis, Zachary M Ashmore, Michael M Bies, James B Meiling, Rajat N Moman, Leslie C Hassett, Christine L Hunt, Steven P Cohen, W Michael Hooten May 2022

Ultrasound-Guided Lumbar Medial Branch Blocks And Intra-Articular Facet Joint Injections: A Systematic Review And Meta-Analysis, Zachary M Ashmore, Michael M Bies, James B Meiling, Rajat N Moman, Leslie C Hassett, Christine L Hunt, Steven P Cohen, W Michael Hooten

Open Access Publications

There is great interest in expanding the use of ultrasound (US), but new challenges exist with its application to lumbar facet-targeted procedures. The primary aim of this systematic review and meta-analysis was to determine the risk of incorrect needle placement associated with US-guided lumbar medial branch blocks (MBB) and facet joint injections (FJI) as confirmed by fluoroscopy or computerized tomography (CT). An a priori protocol was registered, and a database search was conducted. Inclusion criteria included all study types. Risk of bias was assessed using the Cochrane risk of bias tool for randomized controlled trials and the National Heart, Lung, …


Evaluating The Efficacy Of Rib-To-Pelvis Growth-Friendly Surgery For The Treatment Of Non-Ambulatory Early-Onset Scoliosis Myelomeningocele Patients, Norman Ramirez, Gerardo Olivella, Ryan E Fitzgerald, John T Smith, Peter F Sturm, Paul D Sponseller, Lawrence I Karlin, Scott J Luhmann, Norberto J Torres-Lugo, Tricia St Hilaire, Pediatric Spine Study Group May 2022

Evaluating The Efficacy Of Rib-To-Pelvis Growth-Friendly Surgery For The Treatment Of Non-Ambulatory Early-Onset Scoliosis Myelomeningocele Patients, Norman Ramirez, Gerardo Olivella, Ryan E Fitzgerald, John T Smith, Peter F Sturm, Paul D Sponseller, Lawrence I Karlin, Scott J Luhmann, Norberto J Torres-Lugo, Tricia St Hilaire, Pediatric Spine Study Group

Open Access Publications

INTRODUCTION: Early-onset scoliosis (EOS) is a well-known orthopaedic manifestation in patients with myelomeningocele. The rib-based growing system (RBGS) has been proposed as an alternative for these individuals because of the poor outcomes with traditional surgical techniques. We aimed to describe the effect of RBGS in patients with nonambulatory EOS myelomeningocele.

METHODS: We retrospectively reviewed the Pediatric Spine Study Group Multicenter Database for all patients with nonambulatory EOS myelomeningocele treated with RBGS from 2004 to 2019. Demographics, surgical data, radiographic findings, and postoperative complications were obtained. The quality-of-life parameters were assessed postoperatively using the Early-onset Scoliosis Questionnaire-24.

RESULTS: Thirty patients (18 …


Techno-Economic Feasibility Analysis Of A Fully Mobile Radiation Oncology System Using Monte Carlo Simulation, Alex T Price, Casey Canfield, Geoffrey D Hugo, James A Kavanaugh, Lauren E Henke, Eric Laugeman, Pamela Samson, Clair Reynolds-Kueny, Elizabeth A Cudney May 2022

Techno-Economic Feasibility Analysis Of A Fully Mobile Radiation Oncology System Using Monte Carlo Simulation, Alex T Price, Casey Canfield, Geoffrey D Hugo, James A Kavanaugh, Lauren E Henke, Eric Laugeman, Pamela Samson, Clair Reynolds-Kueny, Elizabeth A Cudney

Open Access Publications

PURPOSE: Disparities in radiation oncology (RO) can be attributed to geographic location, socioeconomic status, race, sex, and other societal factors. One potential solution is to implement a fully mobile (FM) RO system to bring radiotherapy to rural areas and reduce barriers to access. We use Monte Carlo simulation to quantify techno-economic feasibility with uncertainty, using two rural Missouri scenarios.

METHODS: Recently, a semimobile RO system has been developed by building an o-ring linear accelerator (linac) into a mobile coach that is used for temporary care, months at a time. Transitioning to a more FM-RO system, which changes location within a …


A Novel Methodological Approach To Simultaneously Extract High-Quality Total Rna And Proteins From Cortical And Trabecular Bone, Martina Faraldi, Laura Mangiavini, Caterina Conte, Giuseppe Banfi, Nicola Napoli, Giovanni Lombardi May 2022

A Novel Methodological Approach To Simultaneously Extract High-Quality Total Rna And Proteins From Cortical And Trabecular Bone, Martina Faraldi, Laura Mangiavini, Caterina Conte, Giuseppe Banfi, Nicola Napoli, Giovanni Lombardi

Open Access Publications

Molecular differences between cortical and trabecular bone, of relevance to understanding the pathophysiological basis of bone diseases, can be determined only through effective isolation methods for RNA and proteins. Here we present a TRIzol-based method, which combines bone pulverization and homogenization to extract simultaneously total RNA and proteins from human cortical and trabecular bone from the same carrot. RNA integrity and purity were determined as the 260/280 nm and 260/230 nm absorbance ratios and the 28S/18S rRNA ratio. Protein integrity and quality were evaluated by Coomassie blue staining. Reverse transcription quantitative polymerase chain reaction and immunoblotting for bone-specific genes and …