Digital Commons Network^™

Linking Spinal Cord Circuits With Upper Limb Sensorimotor Control In Adults With Cerebral Palsy, Saihari Dukkipati

Theses & Dissertations

Cerebral palsy (CP) is the most common neurological disorder originating in childhood, but most of the people living with CP are currently adults. While people with CP continue to get older, the amount of research focused on adults has been rather limited. The early childhood insults leading to CP are thought to originate in the brain, but the effects on the entire neuromuscular system across the lifespan have only recently started to be explored. Of note, recent neuroimaging evidence suggests that the cervical spinal cord structure is atypical in adults with CP. However, it is largely unclear how the neurophysiological …

Genome-Wide Distribution Of Acape1 And Its Implications In Dna Repair And Transcription, Mason Tarpley

Theses & Dissertations

Endogenous DNA damage can occur throughout the genome and is resolved through the Base Excision Repair (BER) pathway. The apurinic/apyrimidinic sites that result from endogenous DNA damage, called AP-sites, are created by DNA glycosylases removing oxidized or modified bases. These AP-sites are primarily repaired by AP endonuclease 1 (APE1) through the BER pathway. Modification of APE1 by acetylation of specific lysine residues in the proteins’ unstructured, N-terminal tail, have been shown to increase the residence time of APE1 (AcAPE1) at the AP-sites. It is unknown where AcAPE1 is binding to chromatin in the genome. Here, we are testing the hypothesis …

Determining The Role Of Mir-133a In The Diabetic Heart, Tyler Kambis

Theses & Dissertations

Diabetes mellitus (DM) is characterized by hyperglycemia, hyperlipidemia, and hypoinsulemia, each of which disrupt intracellular mechanisms in the heart. DM is a chronic metabolic disease delineated into two categories: insulin deficient-type 1 DM and insulin resistant-type 2 DM. Although they differ in underlying genetic and physiological factors, both significantly increase the risk of heart failure. Impaired insulin signaling shifts energy dependency from glycolysis towards fatty acid β-oxidation in the DM heart. This DM-induced metabolic shift increases mitochondrial stress leading to mitochondrial dysfunction and cell death in the heart. The metabolically entwined ferroptosis is a novel form of myocardial cell death …

Metagenome-Wide Associations And Metabolic Modeling To Predict The Biomarkers For Colorectal Cancer, Nagavardhini Avuthu

Theses & Dissertations

Colorectal cancer (CRC) is the most common malignancy and the second most common cause of cancer-related deaths in the world. It is a multifactorial disease mediated by genetic, environmental, and lifestyle factors. Over time, the accumulation of genetic and epigenetic changes results in the activation of oncogenes and deactivation of tumor suppressor genes in the colon and rectal region which finally leads to tumor development. The gut microbiome is the main factor linking the effects of diet and environmental factors to host metabolism. Several studies showed the dysbiosis of gut microbiota in CRC patients with an increased proportion of pathogenic …

Paf1/Pd2 Augments Pancreatic Cancer Progression And Mediates Radiation And Chemoresistance, Sanchita Rauth

Theses & Dissertations

NA

Use Of Machine Learning Algorithms And Highly Multiplexed Immunohistochemistry To Perform In-Depth Characterization Of Primary Pancreatic Tumors And Metastatic Sites, Krysten Vance

Theses & Dissertations

Pancreatic cancer is currently the third leading cause of cancer death and projected to be the second by 2030. Metastatic pancreatic cancer, the most common form of the disease, has a dismal 3% five-year survival rate. However, understanding of the metastatic disease and particularly the metastatic tumor microenvironment (TME), which includes all non-cancerous cells in and around the tumor, has remained limited. The well-documented impact of the TME on cancer cell proliferation, chemoresistance, and patient survival in the primary tumors, indicates that the study of the microenvironment in metastatic cancer is integral to treating advanced patients. To better comprehend this …

Polymeric Nanocarriers For Delivery Of Small Molecules Inhibiting Tubulin Polymerization For The Treatment Of Pancreatic Cancer And Lung Metastatic Melanoma, Rajan Sharma Bhattarai

Theses & Dissertations

The aim of this thesis is to develop delivery systems for the novel small molecules which inhibit tubulin polymerization. One of the small molecules was modified to lipid conjugate to increase the lipophilicity of the molecules which in turn drastically improved the drug loading in amphiphilic polymeric system. The second molecule was conjugated to the amphiphilic polymeric backbone with pH sensitive Schiff’s linker for the tumor site specific delivery in lung metastatic melanoma model.

Chapter 1 discusses the tumor microenvironment for the solid tumor especially focusing on Pancreatic Ductal Adenocarcinoma (PDAC). Further the drug delivery system currently researched for addressing …

Gender Nonconformity In Mexico: A Study Of Community And Isolation In Carmín Tropical, Maddox Arnold

Honors College Theses

As media representation of minority communities becomes more common, it is important to consider how such representation reflects the real-life experience of the communities in question. Rigoberto Pérezcano’s 2014 film Carmín Tropical offers a clear view of the gender nonconforming experience in Mexico. Although Mexico remains one of the deadliest countries for transgender people, over the last decade many states have introduced legislation to advance the rights of the transgender and gender nonconforming community. This places Mexico in a unique position as the country finds itself balancing between violence and progress. Carmín Tropical tells the story of Mabel, a muxe …

Food Insecurity Among Niu College Students, Hannah Schaumberg

Student Projects

Many people with certain privileges never notice them, because they are so fixated on the hasty generalizations of what is seen on the surface rather than the interior aspects. For many students, understanding and recognizing privileges is the main concept to understanding their surroundings. The concept of reflecting on their interactions and knowledge of food insecurity will be curasol among communities. By researching the concepts of food insecurities among NIU students, we can bring awareness of the topic within society. The focus is to understand which intersectional groups are affected by food insecurity and to bring awareness of the subject …

Novel Mobility Device For Conjoined Twins, Allyson Bowgren

Honors Capstones

This project provides a solution to a problem proposed by a pair of conjoined clients. With their desire to become fully independent, the clients need an improved mobility device. Being joined at the head, moving around was always difficult for them and their situation did not get any better after an accident left one of them immobile. Their current device was a decent and quick solution at the time it was first needed. However, since its conception the device quickly became obsolete, and they are now in need of a more effective device that allows them to travel easier. This …

Nitro-Aromatic Polymers For Conversion-Style Battery Cathodic Materials, Brady P. Samuelson

Honors Thesis

The development of organic electrode materials in rechargeable batteries has seen a resurgence in recent decades. This spike in interest is mostly due to the increased investments in renewable energy sources, grid-scale energy storage, and the rapid transition to electric vehicles. Current lithium battery cathode materials typically use some form of lithium metal oxide (specific capacity: 272 mAh g^-1 which has problems with limited capacity, thermal runaway, and an unreliable supply chain. Our research group’s solution involves investigating new lightweight, organic redox groups combined with a conductive polymer backbone to serve as a possible replacement for the cathode in …

Synthesis And Transition Metal-Catalyzed Coupling Of A-Chloro-B-Lactones, Tyler Lynn

Honors Projects

No abstract provided.

Astrocytic Contribution To Sensory Hypersensitivity In A Mouse Model Of Fragile X Syndrome, Lara E. Bergdolt

Theses & Dissertations

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and a leading cause of autism spectrum disorder (ASD). FXS is caused by mutations in the fragile X mental retardation gene (FMR1), which result in complete or substantial loss of expression of its protein product fragile X mental retardation protein (FMRP). Neuronal impairments in the absence of FMRP have been extensively characterized. However, much less is known about the impact that loss of FMRP has on the physiology and function of astrocytes and the implications for behavior. A common behavior exhibited by both FXS and ASD patients …

Magma Production Beneath Subduction Zones: Using Numerical Models To Evaluate Melt Production Under Batch And Fractional Melting Conditions, Francesca Burkett

Honors Theses

No abstract provided.

Reforming The United States’ Currency Production, William Cather

Departmental Honors & Graduate Capstone Projects

Since the 1980s, the debate about the one-cent piece’s production and use has been discussed throughout relatively recent Congressional history; and has involved economic, financial, industry-based, as well as numismatic groups to weigh in on the topic. The question arises: Why have other countries successfully changed their lower-denomination currency and converted their economic system into one that incorporates cash-rounding while the United States has struggled to do so?

By observing international examples of the obsoletion of low-denomination coinage and the implementation of cash-rounding, the proposed economic and financial reform has proved to work as an economically-sound alternative to the current …

Ddx173.1 User Centered Design: Ux Report Presentation Example 1, Sae University College

Exemplars

UX Report for a public transit agency app.

The UX Report delineates the goals and deliverables for a mobile-responsive website. It provides a summary of the findings of a user experience study conducted using the Design Thinking Framework. The report accurately reflects the needs of the intended audience.

Evaluation Of Awareness, Knowledge, And Preventive Intervention Of Nonalcoholic Fatty Liver Disease Among Chinese Young Adults, Yi Du

Theses & Dissertations

The prevalence of nonalcoholic fatty liver disease (NAFLD) among Chinese young adults (CYA) aged 18-25 years ranges from 4.7% to 15.1% and has kept increasing in recent years. Previous studies reported limited awareness and knowledge of NALFD among middle-aged and older Chinese populations, however, they have not investigated awareness in CYA, for which there is no well-validated questionnaire. There is currently no efficacious educational intervention on NAFLD for CYA.

The objectives were 1) to develop and validate a questionnaire which can be used to assess the awareness and knowledge of NAFLD among CYA; 2) to assess the awareness and knowledge …

Contextual Factors And Sti/Hiv Sexual Risk Behaviors Among Hispanic Youths Aged 13 To 24 Years, Mariam Taiwo

Theses & Dissertations

Despite the growing population of Hispanics and several efforts to combat the high STI/HIV rates among Hispanic youths aged 13 to 24 years in the United States, this population continues to experience stark disparities in STI/HIV and is underrepresented in STI/HIV research relative to their White peers. This dissertation consists of three distinct studies designed to identify and understand the contextual factors of STI/HIV sexual risk behaviors across the social-ecological model that are pertinent to Hispanic youths.

Results from the first study showed that STI/HIV sexual risk behavior varied by Hispanic youths’ acculturation types and moderated by gender. We found …

Strengthening Capacity For Clinical And Translational Science: A Multi-Method Assessment Of Research Capacity Development In A Regional Clinical And Translational Research Network, Lakaija Johnson

Theses & Dissertations

The National Institute of Health (NIH) has made significant investments to establish and maintain statewide and regional clinical and translational research (CTR) networks. These networks are designed to accelerate the translation of research discoveries from laboratory and clinical settings to improve community and population health. The National Institute of General Medical Science (NIGMS) Institutional Development Award (IDeA) Program Infrastructure for Clinical and Translational Research (CTR) [IDeA-CTR] initiative was initiated in 2012 to broaden participation in CTR in regions and territories with IDeA designation, having historically been funded by the NIH at lower levels. IDeA-CTR networks stimulate infrastructural investments in complex …

A Comprehensive Analysis Of Concepts And Methodologies In Accounting, Ashley Eickholz

Honors Theses

The following thesis is comprised of thirteen case studies concerning to various accounting concepts and methodologies that are current and relevant to the public accounting industry. These cases include numerous topics learned in financial accounting courses with respect to specific companies and real-world situations. Additionally, two specific cases relate to the recruiting process and potential cities of interest for the internship experience. Each case includes a different topic that reviews accounting theory; thus in combination entails a comprehensive analysis into the sector. The applications of the concepts and methodologies pertain to a future career in the public accounting industry.

These …

Trafficking In Persons: The Reliability Of The Tier Ranking System And Its Ability To Influence Global Policy Decisions, Zoe Storck

Honors Theses

This research investigates the Trafficking in Persons (TIP) report published annually by the United States. Specifically, this research examines both the role that the Trafficking in Persons report plays in pushing specific human rights policy decisions throughout the world and its overall effectiveness in creating governmental response. The tier rankings and country narratives included in the report are essential for identifying specific government responses to recommendations made in the TIP report, and the tier rankings specifically have created a system that pressures countries to pursue steps toward combatting human trafficking. The data collection method utilized throughout this research consists primarily …

Body Image Perceptions Reflected In Social Media: A Guatemalan Instagram Study, Sarah Harris

Honors Theses

Guatemala has faced a long battle with colonialism, civil war, and an ensuing, rapid urbanization. Still today, the country exhibits high levels of malnourishment while also facing an ascending obesity epidemic. This project seeks to explore how the obesity epidemic has changed body image perceptions in the region. Through the use of social media accounts on Instagram, I aim to analyze how Guatemalan influencers use their platform to explore notions of varying body image perceptions in a country where food is culturally significant, malnutrition has plagued many communities, and obesity is growing in prevalence daily. This thesis aims to answer …

On The Intersections Of Childhood Maltreatment, Self-Control, And Behavioral Outcomes Across The Life-Course, Ameleigh Bippen

Honors Theses

Childhood abuse and neglect are highly deleterious experiences that a number of children continue to encounter. The purpose of the current discussion is to examine the impact of childhood abuse and neglect on the growth and development of self-control in early childhood. In service of this goal, several methods were employed, including a review of the historical and current research on the development of self-control. In addition to this, specific scientific theories and their advancements were analyzed to provide further insight into the connection between poor impulse regulation (and decision-making) and downstream linkages with criminal offending. Perhaps not surprisingly, evidence …

The Implementation Of An Authenticity Clause In Social Media Influencers' Contracts, Sarah Tonos

Honors Theses

In the age of social media influencers turning social media platforms into jobs– monetizing pictures of their cats, dancing for dollars, or even making a mockery of themselves for fame and money, the question of whom to trust or distrust has become increasingly important among consumers. As more brands are starting to collaborate with influencers, it is essential to acknowledge the current relationship among all parties involved, including the Federal Trade Commission. There is currently a blurred line among trust, distrust, authenticity, and reliability during sponsorships. The common question among consumers is whether social media influencers believe in the brand …

Mercy Otis Warren’S Marcia(S) And Cornelia(S): A Case Study In Women’S Internalization Of Classicism In Early America, Brittany Ellis

Honors Theses

The connection between people in early America and classicism is a field of study that has been heavily documented, although it has remained a very male-focused field with little research done about how women in early America formed a relationship with antiquity. This thesis reveals that elite white women had a deep emotional and intellectual attachment with mothers and matrons from ancient Greece and Rome as a basis for expressing political thoughts and identity; classicism formed a common language that many women could relate to each other before, during, and after the American Revolution. This assessment is achieved through a …

Effects Of Music Exposure On Autobiographical Memory In Alzheimer's Patients: A Systematic Review And Meta-Analysis, Gregory Vance

Honors Theses

The progression of Alzheimer’s disease is primarily characterized by a loss of memory concerning past events, as well as a lack in ability to create new memories. While this spans across many subsets of memory, such as recognition, recall, and autobiographical memory, there seems to be a lesser impact on musical memory in those with Alzheimer’s. Multiple studies have suggested that exposure to music and introduction of music therapy can even improve other aspects of memory in Alzheimer’s patients. This systematic review and meta-analysis sought to examine the relationship between music exposure and autobiographical memory specifically. A pool of electronic …

Ageism, Eldercare, And Healthcare: An Examination Of Growing Old In Costa Rica, Akshaya Vijayasankar

Honors Theses

The world’s aging population and the Covid-19 pandemic have revealed the high level of ageism against older adults around the globe, which has resulted in an overall decreased quality of life for elders. Societies are now faced with the challenge of creating a suitable and equitable model of care to support their aging population. Despite the recent publication of the World Health Organization's Global Report on Ageism, there is still a large gap in the literature regarding ageism. This paper addresses the issues of institutional ageism in the eldercare and healthcare sector. I argue that Costa Rica serves as a …

Shock Tube Response Of Polycarbonate And Polyvinyl Chloride Exposed To Uv Radiation For Use In Military Application, Tallulah Jones

Honors Theses

As today’s society becomes increasingly more conscious of finding alternative ways to

power our vehicles, research surrounding solar-charged military vehicles is on the rise. With this endeavor comes an engineering feat of discovering the proper material that is cost-effective, wear-resistant, and strong enough to withstand the harsh elements and potentially large impacts that these military-grade vehicles may encounter.

This research tested two types of materials in a shock tube to simulate their behavior in a dynamic impact. These materials were polycarbonate and polyvinyl chloride, more commonly known as PVC. In addition to control samples of both of these materials, samples …

An Exploration Of Physical Education Teachers’ Perceptions Of And Experiences With Body Image, Natallie Noel

Honors Theses

Adolescents experience a broad range of physical and emotional changes and begin looking to peers and social media to determine what their bodies should look like through the lens of society. This process of adolescents beginning to visualize themselves is known as body image. These include physical competence, motivation, self-esteem, and confidence through the way the teachers interact with students, develop positive learning spaces, and develop and implement intentional instruction and programs, thus, providing a space where adolescents begin to develop a healthy perception of their own body (Kerner et al., 2017). However, the breadth of literature on body image, …

A Series Of Case Studies, Bailey Baudier

Honors Theses

Throughout the course of my junior year at the University of Mississippi, I was given the amazing opportunity to work with Dr. Victoria Dickinson and complete my thesis as an accounting major. Each week, we were given a case assignment to work on with a different topic to cover. From potential future living arrangements to researching a financial crisis, our range never settled for anything lower than the high expectations given as an honors student. All of this was used to prepare us for the dedication we needed to put in for our most important assignment. In the last semester …