Digital Commons Network^™

Anti-Amyloid Chimeric Antigen Receptor Macrophages For Alzheimer's Disease Immunotherapy, Qiuyun Pan

McKelvey School of Engineering Graduate Student Theses & Dissertations

Alzheimer’s disease is the most common cause of dementia. None of the available drugs can cure the disease. Chimeric Antigen Receptor (CAR) macrophages, because of their phagocytic activity, have potential as a cellular treatment for amyloid aggregation. In this study, we generated an anti-amyloid CAR hematopoietic progenitor cell line. By inducing the progenitor cell line to differentiate into macrophages, we show that the anti-amyloid CAR-Macrophage has enhanced specific phagocytic activity towards amyloid in in vitro experiments. In addition, in ex vivo experiments, anti-amyloid CAR significantly reduces the plaque load on brain slice from APP/PS1 mice when compared to a non-targeted …

Straining Forward To What Lies Ahead: Models Of Patristic Contemplation, Joshua Vanderhyde

Master of Sacred Theology Thesis

Vanderhyde, Joshua S. “Straining Forward to What Lies Ahead: Models of Patristic Contemplation.” Thesis, Concordia Seminary, 2022. 111 pp.

As secularization sharpens the contrast between Christian belief and western culture, many Christians are looking for ways to take a more active and intentional approach to the struggle to be conformed to Christ. The Church Fathers offer a unified theory of Christian spirituality, grounded and structured by the concept of contemplation—a theory of perception widely held in the ancient world and integral to diverse systems of thought, including Neoplatonism. In this thesis, the concept of contemplation is elucidated as a theory …

Investing Green To Become More Green: An Analysis Of Whether S&P 100 Companies Are Decreasing Their Carbon Footprint Proportional To Their Liquidity, Ashley Hendler, Ethan Hunter

Senior Honors Papers / Undergraduate Theses

Global warming may have ignited the flame in corporations to invest in the changing business and environmental climate. The importance of a broader stakeholder value perspective has grown as firms have impacted the global environment. The S&P 100 firms are at the forefront of the public’s attention in maximizing shareholder and stakeholder value. With the worldwide expectation for corporate social responsibility, these top firms are not in question of whether they are investing in sustainability initiatives but to what extent. We seek to decipher if these top corporations are reducing their carbon footprint proportional to their excess available funds. Since …

Online Teaching Self-Efficacy: An Explanatory Case Study, Lady Moran

Electronic Theses and Dissertations Archive

Data reveals growth in online learning enrollment; additionally, university strategic initiatives and emergency response efforts include reliance on online education. However, the literature indicates that many who teach in post-secondary institutions are reluctant to adopt online education. There is a need to reduce existing barriers regarding online education and build instructor online teaching self-efficacy. A suggestion for increasing online instructor self-efficacy exists within the bounds of professional development. A qualitative explanatory case study was used to determine how the completion of the Quality Matters Applying the Quality Matters Rubric (APPQMR) workshop, a training rooted in best practices of course design, …

A Social-Ecological-Technological Systems Framework For Urban Ecosystem Services, Timon Mcphearson, Elizabeth M. Cook, Marta Berbés-Blázquez, Chingwen Cheng, Nancy B. Grimm, Erik Andersson, Olga Barbosa, David G. Chandler, Heejun Chang, Multiple Additional Authors

Geography Faculty Publications and Presentations

As rates of urbanization and climatic change soar, decision-makers are increasingly challenged to provide innovative solutions that simultaneously address climate change impacts and risks and inclusively ensure quality of life for urban residents. Cities have turned to nature-based solutions to help address these challenges. Nature-based solutions, through the provision of ecosystem services, can yield numerous benefits for people and address multiple challenges simultaneously. Yet, efforts to mainstream nature-based solutions are impaired by the complexity of the interacting social, ecological, and technological dimensions of urban systems. This complexity must be understood and managed to ensure ecosystem-service provisioning is effective, equitable, and …

The Effects Of The “Chinese Virus” On The Asian American And Pacific Islander Community: Hate Crimes, Discrimination, And Violence, Emily Chang

Undergraduate Honors Theses

With the spread of the global health crisis that is COVID-19, hate crimes towards Asian Americans and Pacific Islanders (AAPIs) have skyrocketed in the U.S., largely due to the charged rhetoric and misperceptions perpetrated by the U.S. government that link COVID-19 to people of Asian descent. This project analyzes the history of discrimination towards AAPIs in the United States and its present-day context. Moreover, this analysis reveals the detrimental effects of verbal and physical assaults on the emotional and physical health of AAPIs and explores the possible solutions we can implement to decrease these crimes. Finally, I consider the implications …

Application Of Neural Networks To Predict Patient-Specific Cellular Parameters In Computational Cardiac Models, Chang Hi Lee

McKelvey School of Engineering Graduate Student Theses & Dissertations

Sudden cardiac death(SCD) is a significant cause of death that accounts for more than 180,000 deaths in the US and 4 million deaths worldwide annually. SCDs are mainly caused by irregular heartbeats called arrhythmias, which are caused by abnormal electrical activity within the heart. Precision medicine, in the form of personalized computational cardiac models of a patient’s heart, can suggest optimal therapies for cardiac arrhythmias. Prior work has used finite element meshes derived from cardiac MRIs to simulate cardiac electrical activity. In this study, I sought to augment this approach by developing a neural network to learn the parameters that …

Design Of An Offner-Chrisp Imaging Spectrometer For A Planetary Fluorescence Instrument, Tristan Wells Carlson

McKelvey School of Engineering Graduate Student Theses & Dissertations

Spectrometers have been an integral part of space exploration in the late 20th and 21st centuries and will continue to provide quantitative measurements to answer exciting questions like, “Is or was there life on other planets?” PERISCOPE, Probe for Exploring Regolith and Ice by Subsurface Classification of Organics, Polycyclic aromatic hydrocarbons, and Elements, is a next generation spectrometer designed to explore icy worlds like Europa. It uses time-resolved ultraviolet (UV) fluorescence spectroscopy, a technique that identifies organic molecules, polycyclic aromatic hydrocarbons (PAH), and rare earth elements (REE). Photon wavelength discrimination is very important for this technique and is accomplished by …

The Wizard's Alphabet Book: Illustration As Counter-Environment To The Digital World, Stephen Barany

MFA in Illustration & Visual Culture

This thesis essay accompanies a built installation of twenty-six densely drawn illustrations, each consisting of numerous creatures and objects whose names all begin with the same letter. Thus, each illustration represents a different letter of the alphabet. Printed on cloud-shaped substrates and suspended as a group in a 10”x10” ring, the array of illustrations form a small space where viewers can immerse themselves in the act of free and careful looking. This essay elaborates on the ideas that propelled the design and construction of this illustrated installation.

This essay explores the potential for illustration to create a space for looking …

Home Suite Home: An Analysis Of Comfort In Americana And Motel Culture, Jodi Kolpakov

MFA in Illustration & Visual Culture

This essay provides a critical look at the motel, investigating it as a souvenir, exploring its nostalgic phenomenon, and questioning its complexity of comfort. We begin by looking at the evolution of the motel and how its strange stereo- type came to be. I dissect the terms “shady” and “sketchy” as both a psychological and illustrated representation of the motel while closely reading how these terms appear in other forms of media, such as Bates Motel and Bad Times at the El Royale. Through exploring nostalgic Americana, I investigate how motels connect us from the past to the pres- …

A Perfect Escape: Fantasy, Place And Narrative In Adolescence, Cydney Cherepak

MFA in Illustration & Visual Culture

This essay explores the realms of special places, the literary genre of fantasy, narrative, and comics. These topics are traversed alongside subjects of adolescence and the creation of stories for middle-grade readers. Framed with personal stories, as well as peaks into my process, I investigate these subjects through the lens of my own life and work, specifically my thesis project, a comic for middle-grade readers titled Beyond the Castle Walls. Beginning with adolescence in association with special places, I consider the work of developmental psychologists David Sobel and Edith Cobb as they pin-point the role of secret forts, nature, …

Application Of Crowdsourcing And Machine Learning To Predict Sentiments In Textual Student Feedback In Large Computer Science Classes, Robert Kasumba

McKelvey School of Engineering Graduate Student Theses & Dissertations

With the increasing enrollment numbers into popular computer science courses, there is a need to bridge the similarly increasing feedback gap between individual students and course instructors. One way to address this challenge is for instructors to collect feedback from students in form of textual reviews or unit-of-study reflections – however, manually reading these reviews is time-consuming, and self-reported Likert scale responses are noisy. Rule-based approaches to sentiment analysis such as VADER (Valence Aware Dictionary and sEntiment Reasoner) have been used to capture the sentiments conveyed in textual feedback, they however fail to capture contextual differences as many words have …

Storytelling For A Changing World: Comics As Agitprop, Kruttika Susarla

MFA in Illustration & Visual Culture

This essay imagines fictional storytelling and urban practices of maintenance, repair, and care as interrelated to one another. They are both practices engaged in building a better world. Urban scholars like Gautam Bhan, Shannon Mattern, and David Harvey propose the city as a space for envisioning the kind of community we want to be—a space for working towards our collective future. By engaging in fictional storytelling, I argue, we are doing the same thing: the dual work of taking from fact and representing it to an audience while also engaging in imagining and world-building. This is also a practice of …

On The Value Of Operational Flexibility In Anheuser Busch Inbev’S Trailer Loading And Shipment Problem: Data-Driven Approaches And Reinforcement Learning, Yunsi Yang

Doctor of Business Administration Dissertations

This paper introduces the Anheuser Busch Inbev (ABI)'s trailer shipment problem and suggests data-analytics methodologies to deal with it. The problem is to determine the proper weight of products loaded on a trailer (a transporting container) owned by ABI, which is delivered by a tractor (a motor vehicle) owned by third-party logistics (3PL) providers. ABI must meet a regulation that restricts the gross weight of the truck on the road. However, the challenge comes from the fact that the tractor weight is uncertain and unknown to ABI when it determines the load size on the trailer. We suggest machine learning …

2022 Draft Final Insufficiently Reclaimed Sites Quality Assurance Project Plan (Qapp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Potential Of Service Learning In Rural Schools: The Case Of The Working Together Project, Benjamin Ingman, Katie Lohmiller, Nick Cutforth, Elaine Belansky

The Rural Educator

Service learning has been established as a promising method of teaching and learning that engages youth as change agents in their schools and communities. But service learning has not been widely implemented or studied in rural K-12 schools. This study explores the case of a service learning curriculum, the Working Together Project (WTP), in a rural, high-poverty school. Data collection included classroom observations, surveys, and individual/focus group interviews with participants of the curriculum. The case study findings illustrate how the WTP curriculum unfolded with students, benefits for the school (cross-generational collaboration, school introspection and improvement), benefits for the students (collaborative …

A Critical Review Of Bioaccumulation And Biotransformation Of Organic Chemicals In Birds, Dave T. F. Kuo, Barnett A. Rattner, Sarah C. Marteinson, Robert Letcher, Kim J. Fernie, Gabriele Treu, Markus Deutsch, Mark S. Johnson, Sandrine Deglin, Michelle Embry

United States Geological Survey: Staff Publications

A literature review of bioaccumulation and biotransformation of organic chemicals in birds was undertaken, aiming to support scoping and prioritization of future research. The objectives were to characterize available bioaccumulation/ biotransformation data, identify knowledge gaps, determine how extant data can be used, and explore the strategy and steps forward. An intermediate approach balanced between expediency and rigor was taken given the vastness of the literature. Following a critical review of >500 peer-reviewed studies, >25,000 data entries and 2 million information bytes were compiled on >700 organic compounds for ~ 320 wild species and 60 domestic breeds of birds. These data …

Adverse Radiation Effect And Freedom From Progression Following Repeat Stereotactic Radiosurgery For Brain Metastases, Michael Mcdermott

All Publications

Objective: The authors previously evaluated risk and time course of adverse radiation effects (AREs) following stereotactic radiosurgery (SRS) for brain metastases, excluding lesions treated after prior SRS. In the present analysis they focus specifically on single-fraction salvage SRS to brain metastases previously treated with SRS or hypofractionated SRS (HFSRS), evaluating freedom from progression (FFP) and the risk and time course of AREs.

Methods: Brain metastases treated from September 1998 to May 2019 with single-fraction SRS after prior SRS or HFSRS were analyzed. Serial follow-up magnetic resonance imaging (MRI) and surgical pathology reports were reviewed to score local treatment failure and …

Experimental And Numerical Investigation Of 3d-Printed Viscoelastic Dampers, Mohammed Jaradat

Civil Engineering ETDs

Elastomeric materials are extensively used in energy dissipation applications to mitigate large lateral displacements and attenuate vibrations. One way of exploiting the capabilities of elastomeric materials is using shear-damping mechanisms such as viscoelastic damping devices (VEDs).

In this research the freedom of design offered by additive manufacturing technology is utilized to produce 3D printed elastomeric parts that act as the viscoelastic layer in an energy damping device. A mechanically interlocked viscoelastic damper (MIVED) with a jigsaw-like interlocking mechanism was designed and manufactured. MIVED is composed of a rigid and soft phase. It operates in two modes, modes I and II, …

Library Support Services At The University Of Zambia Amid The Covid-19 Pandemic: A Swot Matrix, Pailet Chewe, Zachary Zulu Mr., Mercy M. Wamunyima Mrs., Given M. Kuntumoya Ms, Celine M. Mwafulilwa Mrs., Sarah T. Gwayi Mrs., Fabian Kakana Mr., Eness M.M. Chitumbo Mrs., Gelvazio Sakala Mr., Christine W. Kanyengo Ms, Judith Banda Mrs, Francina N.S. Makondo Mrs.

Library Philosophy and Practice (e-journal)

When the Coronavirus disease (COVID-19) forced learning institutions in Zambia to abruptly transition to virtual instruction, library services adapted quickly to provide research services, instruction, and access to collections. This paper details how the University of Zambia Library used a SWOT (Strengths, Weaknesses, Opportunities and Threats) Analysis framework to evaluate academic support services of the Library in the wake of the Covid-19 pandemic. Key variables included the library collections, staffing, services and technology. The analysis revealed that strengths comprised qualified staff, technology support and a rich collection of information resources. Weaknesses are in the areas of poor funding and low …

Record Management And Services Delivery Of Independent National Electoral Commission (Inec) Delta State Chapter, Chibueze Norbert Onwuekwe, Awajionyi Blessing Suleiman

Library Philosophy and Practice (e-journal)

ABSTRACT This research work investigated the record management and services delivery of Independent National Electoral Commission (INEC) Delta state chapter. The study was carried out by using descriptive survey research design. Three specific objectives, three research questions were formulated to guide the study. The population of the study comprises 452 staff of Independent National Electoral Commission (INEC) Delta state chapter, with sample size of 213 staff. Questionnaire was used as instrument for data collection. Data was analysed with descriptive statistics. The findings of the study revealed that INEC make use of online storage, such as website/webpage and email, and the …

Investigation Of Factors Affecting Covid-19 Vaccine Acceptance Among Communities Of Universities In The United Arab Emirates., Maisa El Gamal, Ayisha Siddiqua, Waheed Kareem Abdul, Badria H Almurshidi, Fares M Howari

All Works

The COVID-19 pandemic affected the lives of people living across the world and the development of vaccines against SARS-CoV-2 is considered to be one of the most promising solutions to contain the COVID-19 pandemic. In several countries, we are witnessing hesitancy toward COVID-19 vaccines, which is a complex phenomenon influenced by a variety of factors. A cross-sectional study was performed to comprehensively investigate the impact of factors like demography, COVID-19 pandemic-induced behavior, and vaccine attitude on COVID-19 vaccine acceptance (VA) among communities of five different universities in the United Arab Emirates (UAE). To investigate the effect of demography and COVID-19 …

Nsf Award Will Boost Uab Research In Machine-Learning-Enabled Plasma Synthesis Of Novel Materials, Jeff Hansen

Browse All News

No abstract provided.

Unifying Text And Music: Applying Shurtleff's Twelve Guideposts To Operatic Arias For Soprano, Jamey J. Wright

LSU Doctoral Dissertations

In the present culture of operatic performance, artistry is measured not only by singers’ musical interpretation and vocal technique, but also by their ability to communicate compelling characterization. This monograph explores a helpful technique for dramatic interpretation in opera. The discipline of musical performance provides helpful guides to characterization through elements such phrasing, rhythm, harmony, and instrumentation. Techniques borrowed from the spoken theater, particularly those pioneered by Constantin Stanislavski, include the Magic If, objectives, actions, and tactics. The literature on auditioning for the theater is useful for synthesizing these techniques for singers, because audition techniques emphasize compelling characterization with …

Open Hardware In Science: The Benefits Of Open Electronics, Michael Oellermann, Jolle W. Jolles, Diego Ortiz, Rui Seabra, Tobias Wenzel, Hannah Wilson, Richelle L. Tanner

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Openly shared low-cost electronic hardware applications, known as open electronics, have sparked a new open-source movement, with much untapped potential to advance scientific research. Initially designed to appeal to electronic hobbyists, open electronics have formed a global “maker” community and are increasingly used in science and industry. In this perspective article, we review the current costs and benefits of open electronics for use in scientific research ranging from the experimental to the theoretical sciences. We discuss how user-made electronic applications can help (I) individual researchers, by increasing the customization, efficiency, and scalability of experiments, while improving data quantity and quality; …

One Size Doesn’T Fit All: Towards Optimising The Therapeutic Potential Of Endogenous Pain Modulatory Systems, K Bannister, S Hughes

School of Psychology

Introduction. Top–down processing pathways modulate neuronal transmission at the level of the spinal cord dorsal horn and thus govern, in part, the percept of pain. In health, these descending control systems can give rise to a naturally occurring form of pain inhibition. Despite a high therapeutic potential, the clinical applicability of harnessing such endogenous systems has not been fully realised. We propose that this is due to several complicating issues. First, the descending pain modulatory system (DPMS) is influenced by sensory as well as affective brain circuits. Thus, because of the bidirectional nature of the DPMS, pain may be facilitated …

Copper(I)‒Pyrazolate Complexes As Solid-State Phosphors: Deep-Blue Emission Through A Remote Steric Effect, Yuichiro Watanabe, Benjamin M. Washer, Matthias Zeller, Sergei Savikhin, Lyudmila V. Slipchenko, Alexander Wei

Department of Chemistry Faculty Publications

We describe a novel manifestation of rigidochromic behavior in a series of tetranuclear Cu(I)–pyrazolate (Cu4pz4) macrocycles, with implications for solid-state luminescence at deep-blue wavelengths (< 460 nm). The Cu4pz4 emissions are remarkably sensitive to structural effects far from the luminescent core: when 3,5-di-tert-butylpyrazoles are used as bridging ligands, adding a C4 substituent can induce a blue shift of more than 100 nm. X-ray crystal and computational analyses reveal that C4 units influence the conformational behavior of adjacent tert-butyl groups, with a subsequent impact on the global conformation of the Cu4pz4 complex. Emissions are mediated primarily through a cluster-centered triplet (3CC) state; compression of the Cu4 cluster into a nearly close-packed geometry prevents the reorganization of its excited-state structure and preserves the 3CC energy at a high level. The remote steric effect may thus offer alternative strategies toward the design of phosphors with rigid excited-state geometries.

Disadvantaged Students’ Experiences With Social Studies Distanced Learning: A Phenomenological Study, Supardi Supardi

The Qualitative Report

Distanced learning, for most people, is synonymous with internet-based education and high technology. High technology-based learning in distanced learning contrasts with the distributed learning experienced by children in disadvantaged areas. This topic is complex and requires attention so that no child is left behind; yet it is rarely discussed in literary works, especially the facts of distanced learning without the internet from students' point of view who directly experience the phenomenon. This study aims to explore students’ experiences in disadvantaged areas in Indonesia regarding the implementation of distanced learning during the COVID-19 pandemic. In the process of in-depth individual interviews …

Using A Network Model To Control The Spread Of An Infectious Disease On A College Campus With Contact Tracing, Christopher R. Boyette

Biology and Medicine Through Mathematics Conference

No abstract provided.

Understanding Biofilm-Phage Interactions In Mathematical Framework, Blessing Emerenini

Biology and Medicine Through Mathematics Conference

No abstract provided.