Digital Commons Network^™

E Pluribus Unum: Prospective Acceptability Benchmarking From The Contouring Collaborative For Consensus In Radiation Oncology Crowdsourced Initiative For Multiobserver Segmentation, Diana Lin, Kareem A Wahid, Benjamin E Nelms, Renjie He, Mohammed A Naser, Michael V Sherer, Abdallah S R Mohamed, Michael Cislo, James D Murphy, Clifton D Fuller, Erin F Gillespie

Faculty, Staff and Student Publications

Purpose: Contouring Collaborative for Consensus in Radiation Oncology (C3RO) is a crowdsourced challenge engaging radiation oncologists across various expertise levels in segmentation. An obstacle to artificial intelligence (AI) development is the paucity of multiexpert datasets; consequently, we sought to characterize whether aggregate segmentations generated from multiple nonexperts could meet or exceed recognized expert agreement.

Approach: Participants who contoured ≥1 region of interest (ROI) for the breast, sarcoma, head and neck (H&N), gynecologic (GYN), or gastrointestinal (GI) cases were identified as a nonexpert or recognized expert. Cohort-specific ROIs were combined into single simultaneous truth and performance level estimation (STAPLE) consensus segmentations. …

Cotargeting Of Btk And Malt1 Overcomes Resistance To Btk Inhibitors In Mantle Cell Lymphoma, Vivian Changying Jiang, Yang Liu, Junwei Lian, Shengjian Huang, Alexa Jordan, Ruitao Lin, Joseph Mcintosh, Yijing Li, Yuxuan Che, Zhihong Chen, Jovanny Vargas, Maria Badillo, John Nelson Bigcal, Heng-Huan Lee, Wei Wang, Yixin Yao, Lei Nie, Christopher R Flowers, Michael Wang

Faculty, Staff and Student Publications

Bruton's tyrosine kinase (BTK) is a proven target in mantle cell lymphoma (MCL), an aggressive subtype of non-Hodgkin lymphoma. However, resistance to BTK inhibitors is a major clinical challenge. We here report that MALT1 is one of the top overexpressed genes in ibrutinib-resistant MCL cells, while expression of CARD11, which is upstream of MALT1, is decreased. MALT1 genetic knockout or inhibition produced dramatic defects in MCL cell growth regardless of ibrutinib sensitivity. Conversely, CARD11-knockout cells showed antitumor effects only in ibrutinib-sensitive cells, suggesting that MALT1 overexpression could drive ibrutinib resistance via bypassing BTK/CARD11 signaling. Additionally, BTK knockdown and MALT1 knockout …

Automatic Diagnosis Of Late-Life Depression By 3d Convolutional Neural Networks And Cross-Sample Entropy Analysis From Resting-State Fmri, Chemin Lin, Shwu-Hua Lee, Chih-Mao Huang, Guan-Yen Chen, Wei Chang, Shu-Hang Ng, Shun-Chi Wu

Faculty, Staff and Student Publications

Resting-state fMRI has been widely used in investigating the pathophysiology of late-life depression (LLD). Unlike the conventional linear approach, cross-sample entropy (CSE) analysis shows the nonlinear property in fMRI signals between brain regions. Moreover, recent advances in deep learning, such as convolutional neural networks (CNNs), provide a timely application for understanding LLD. Accurate and prompt diagnosis is essential in LLD; hence, this study aimed to combine CNN and CSE analysis to discriminate LLD patients and non-depressed comparison older adults based on brain resting-state fMRI signals. Seventy-seven older adults, including 49 patients and 28 comparison older adults, were included for fMRI …

Aapm Btsc Report 377: Physicist Brachytherapy Training In 2021-A Survey Of Therapeutic Medical Physics Residency Program Directors, Manik Aima, Samantha J Simiele, Susan L Richardson, Christopher S Melhus

Faculty, Staff and Student Publications

BACKGROUND: Brachytherapy (BT) was the first radiotherapeutic technique used to treat human disease and remains an essential modality in radiation oncology. A decline in the utilization of BT as a treatment modality has been observed and reported, which may impact training opportunities for medical physics residents. A survey of therapeutic medical physics residency program directors was performed as part of an assessment of the current state of BT training during residency.

METHODS: In March 2021, a survey consisting of 23 questions was designed by a working unit of the Brachytherapy Subcommittee of the American Association of Physicists in Medicine (AAPM) …

Dual Beam-Current Transformer Design For Monitoring And Reporting Of Electron Ultra-High Dose Rate (Flash) Beam Parameters, Kevin Liu, Allison Palmiero, Nitish Chopra, Brett Velasquez, Ziyi Li, Emil Schüler

Faculty, Staff and Student Publications

PURPOSE: To investigate the usefulness and effectiveness of a dual beam-current transformer (BCTs) design to monitor and record the beam dosimetry output and energy of pulsed electron FLASH (eFLASH) beams in real-time, and to inform on the usefulness of this design for future eFLASH beam control.

METHODS: Two BCTs are integrated into the head of a FLASH Mobetron system, one located after the primary scattering foil and the other downstream of the secondary scattering foil. The response of the BCTs was evaluated individually to monitor beam output as a function of dose, scattering conditions, and ability to capture physical beam …

Crypto Assets And The Problem Of Tax Classifications, Eric D. Chason

Faculty Publications

To date, Internal Revenue Service (I.R.S.) guidance on cryptocurrencies has been thin. When the I.R.S. has issued guidance, it occasionally mishandles the technical details (such as confusing air drops and hard forks). More personnel (and personnel with greater technical expertise) would allow the I.R.S. to keep pace with the explosive growth of cryptocurrency. Nevertheless, the I.R.S. could better leverage its existing resources by focusing on select issues and seeking enabling legislation from Congress. Specifically, the I.R.S. should focus on crypto issues occurring on a system-wide basis and not requiring taxpayer-specific considerations.

For example, determining whether Bitcoin is a “security” under …

Percutaneous Revascularization For The Treatment Of Refractory Digital Ischemia In Systemic Sclerosis

Faculty, Staff and Student Publications

OBJECTIVE: The objective of this study is to explore the role of adjunctive percutaneous revascularization of the hand in the management of patients with systemic sclerosis-associated refractory digital ischemia.

METHODS: We present our initial experience of using percutaneous upper extremity interventions to treat patients with systemic sclerosis and symptomatic Raynaud's phenomenon who presented with either refractory digital ischemia or non-healing ulcers. We discuss patient characteristics, procedural findings, and short-term clinical outcomes of these interventions.

RESULTS: We performed 14 interventions in 6 patients with non-healing digital ulcers or refractory ischemia secondary to systemic sclerosis. Angioplasty was performed at or below the …

Association Of Metformin With The Development Of Age-Related Macular Degeneration, Christine H Darwin, Neil H White, Emily Y Chew

Faculty, Staff and Student Publications

IMPORTANCE: Age-related macular degeneration (AMD) is a leading cause of blindness with no treatment available for early stages. Retrospective studies have shown an association between metformin and reduced risk of AMD.

OBJECTIVE: To investigate the association between metformin use and age-related macular degeneration (AMD).

DESIGN, SETTING, AND PARTICIPANTS: The Diabetes Prevention Program Outcomes Study is a cross-sectional follow-up phase of a large multicenter randomized clinical trial, Diabetes Prevention Program (1996-2001), to investigate the association of treatment with metformin or an intensive lifestyle modification vs placebo with preventing the onset of type 2 diabetes in a population at high risk for …

Association Of Frailty And The Expanded Operative Stress Score With Preoperative Acute Serious Conditions, Complications, And Mortality In Males Compared To Females: A Retrospective Observational Study, Katherine Moll Reitz, Ada Youk, Chen-Pin Wang, Jonathan C Silverstein, Elmer V Bernstam, Paula K Shireman

Faculty, Staff and Student Publications

OBJECTIVE: The aim of this study was to expand Operative Stress Score (OSS) increasing procedural coverage and assessing OSS and frailty association with Preoperative Acute Serious Conditions (PASC), complications and mortality in females versus males.

SUMMARY BACKGROUND DATA: Veterans Affairs male-dominated study showed high mortality in frail veterans even after very low stress surgeries (OSS1).

METHODS: Retrospective cohort using NSQIP data (2013-2019) merged with 180-day postoperative mortality from multiple hospitals to evaluate PASC, 30-day complications and 30-, 90-, and 180-day mortality.

RESULTS: OSS expansion resulted in 98.2% case coverage versus 87.0% using the original. Of 82,269 patients (43.8% male), 7.9% …

Assessment Of Symptom, Disability, And Financial Trajectories In Patients Hospitalized For Covid-19 At 6 Months, Sarina K Sahetya, Kelly C Vranas, Kirby P Mayer, Aluko A Hope, Sarah E Jolley, Ellen Caldwell, Max L Monahan, Katrina Hauschildt, Samuel M Brown, Neil R Aggarwal, B Taylor Thompson, Catherine L Hough

Faculty, Staff and Student Publications

IMPORTANCE: Individuals who survived COVID-19 often report persistent symptoms, disabilities, and financial consequences. However, national longitudinal estimates of symptom burden remain limited.

OBJECTIVE: To measure the incidence and changes over time in symptoms, disability, and financial status after COVID-19-related hospitalization.

DESIGN, SETTING, AND PARTICIPANTS: A national US multicenter prospective cohort study with 1-, 3-, and 6-month postdischarge visits was conducted at 44 sites participating in the National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Network's Biology and Longitudinal Epidemiology: COVID-19 Observational (BLUE CORAL) study. Participants included hospitalized English- or Spanish-speaking adults without severe prehospitalization …

Clinical Characteristics, Microbiology And Outcomes Of A Cohort Of Patients Treated With Ceftolozane/Tazobactam In Acute Care Inpatient Facilities, Houston, Texas, Usa, Faris Alnezary, Kirsten Rydell, Rafael Rios, Lorena Diaz, Blake M Hanson, Jose M Munita, Claudia Pedroza, Samuel A Shelburne, Samuel L Aitken, Kevin W Garey, Ryan Dillon, Laura Puzniak, Cesar A Arias

Faculty, Staff and Student Publications

BACKGROUND: Ceftolozane/tazobactam is a β-lactam/β-lactamase inhibitor combination with activity against a variety of Gram-negative bacteria, including MDR

METHODS: We conducted a multicentre retrospective study of patients receiving at least 48 h of ceftolozane/tazobactam therapy from January 2016 through to September 2019 at two hospital systems in Houston. Demographic, clinical and microbiological data were collected, including the infecting bacterial isolate, when available. The primary outcome was composite clinical success at hospital discharge. Secondary outcomes included in-hospital mortality and clinical disposition at 14 and 30 days post ceftolozane/tazobactam initiation. Multivariable logistic regression analysis was used to identify predictors of the primary outcome …

Inflation-Adjusted Medicare Reimbursement For Hip Arthroscopy Fell By 211% On Average Between 2011 And 2022, Paulo Padilla

Faculty, Staff and Student Publications

PURPOSE: To examine Medicare reimbursement for hip arthroscopy from 2011 to 2022.

METHODS: The seven most common procedures performed with hip arthroscopy by a single surgeon were gathered. The Physician Fee Schedule Look-Up Tool was utilized to access financial data of the associated Current Procedural Terminology (CPT) codes. The reimbursement data for each CPT were gathered from the Physician Fee Schedule Look-Up Tool. With the consumer price index database and inflation calculator, reimbursement values were adjusted for inflation to 2022 U.S. dollars.

RESULTS: Following an adjustment for inflation, it was found that reimbursement rate for hip arthroscopy procedures on average …

Genetic Determinants Involved In Acquisition Of Iron In The Opportunistic Pathogen Mycobacterium Abscessus, Manal F. Farhat

Dissertations, Theses, and Capstone Projects

The opportunistic pathogen Mycobacterium abscessus subsp. abscessus (Mab) has become an emerging public health threat due to the increasing number of Mab-associated chronic pulmonary disease cases. Infection cure rates are only 50% due to the complex resistance of Mab to most antimicrobial drugs and chemotherapy.

Deeper knowledge of Mab biology is needed to illuminate potential candidates for development of improved therapeutics against Mab infections. The ESX-3 type VII protein secretion system of Mab plays an important role in host inflammatory and pathological responses during infection.

In this study, we demonstrate a functional link between the ESX-3 secretion …

Optimized Peptide Nanomaterials As Delivery Vehicles For Hydrophobic Metal-Based Anticancer Agents, Yaron Marciano

Dissertations, Theses, and Capstone Projects

Enzyme-responsive materials have been well explored, particularly as therapeutic and diagnostic agents. In this thesis we demonstrate that anionic self-assembling peptides can be utilized as delivery vehicles for metal-based hydrophobic payloads. The tunability of the system is highlighted as well as the increase in cytotoxicity and selectivity in vitro. The rapid degradation of peptides in cell media may lead to the formation of new peptide-drug bioconjugates with increased activity and selectivity. The physiological stability of these peptide delivery vehicles has been optimized by capping the N-terminus with an acetyl group. This simple backbone modification was shown to not prevent self-assembly, …

Design And Applications Of Fmoc-Histidine And Aspartic Acid Tripeptides As Proton Conductive Materials, Shejla S. Pollozi

Dissertations, Theses, and Capstone Projects

The increasing demand for clean and sustainable energy has driven forward rapid improvements in polymer-electrolyte fuel cells and the use of ion-conducting polymers (ionomers) as proton exchange membranes and catalyst binders. While perfluorinated electrolytes have been commercially used as conductive membranes for nearly four decades, a new class of sustainable, conductive materials has emerged, inspired by the efficiency of charge transport processes in biological systems. These molecules, knows as peptide amphiphiles (PAs), have gained popularity as building blocks for the bottom-up fabrication of nanomaterials through supramolecular self-assembly. Supramolecular nanostructures, often in the form of hydrogels, are held together via non-covalent …

Social Identity, Scientific Practice, And The Production Of Social Knowledge: An Ethnographic Investigation Of American Social Psychology Laboratories, Donald V. Brown Jr

Dissertations, Theses, and Capstone Projects

Social identity has the ability to permeate a multitude of domains in everyday life. Therefore, the science of social psychology—influential due to its impact in education, social and public policy, and the law—rightfully foregrounds the presence of social identity categories in the theorizing and empirical work of the discipline. Many researchers consider social identities such as race and gender to be socially constructed categories. This allows researchers to understand these identities in light of their history, complexity, and relationships to each other. However, the practical application and use of social identities as socially constructed “objects of study” is uncommon in …

Kingdoms Becoming: Dialectic Of Black Romanticism, Rasheed M. Hinds

Dissertations, Theses, and Capstone Projects

Kingdoms Becoming emphasizes the profound impact that biblical prophecy, the slave trade, and the American Revolution had on Romanticism, Black nationalism, and horizontal transnationalism. Whereas current scholarship identifies the French Revolution as the seismic shift that inspired British Romanticism and caused a resurgence in prophetic enthusiasm, the American Revolution represents the advent of Black Romanticism and inchoate Black nationalism; this cataclysmic event introduced Afro-British identity, Black Romantic prophecy, and Black nationalist sentiment to the English nation. While many scholars have underscored the ways in which the abolitionist movement informed both British and Black Romanticism and sparked a transnational human-rights movement, …

How The U.S. Mainstream Media Perpetuates Cis White Masculine Hegemony, Yelena Dzhanova

Dissertations, Theses, and Capstone Projects

The news is important because it helps individuals understand their place in the world and make the best decisions for themselves. Throughout its strong history and presence in the United States, the journalism industry has prided itself on delivering fact-based news using an objective framework, meaning that there is an expectation that journalists communicate the news impartially and without bias. Through an examination of gendered language and visual representations published in and by recent mainstream U.S. digital and print media outlets, this paper explains how the media plays a major role in the perpetuation of cis white masculinity. This paper …

Ornamentalism: Costuming And The Portrayal Of The Chinese Woman In Film, 20th-21st Century, Andrea Yepez

Dissertations, Theses, and Capstone Projects

This thesis aims to analyze the concept of “Ornamentalism,” a term created by Anne Anlin Cheng. In Ornamentalism (2019), Cheng proposes the term—a combination of Orientalism and ornament—as a new way to study Asiatic femininity. Cheng applies the term to a case study of the career of Anna May Wong, the first Asian-American actress to feature in Hollywood films. Throughout her career, which began in the 1920s, Anna May Wong held the status of it-girl and muse to designers such as John Galliano. However, Wong was also subjected to playing stereotypical Asian roles in films and was consistently the victim …

Literature, Development, And The Reaches Of Literacy, 1979 To The Present, Stephen Tremaine

Dissertations, Theses, and Capstone Projects

In this study, I examine the twentieth century’s vast history of large-scale literacy campaigns and the imprints and legacies of those campaigns in literary texts from the global South. Literary texts by Mahasweta Devi, Nuruddin Farah, J. M. Coetzee, M. G. Vassanji, Abdulrazak Gurnah, and others provide compelling examples of narratives that foreground literacy - particularly its acquisition, loss, or redistribution in the lives, communities, and emerging independent nations in which these narratives take place. The second half of the twentieth century represents a global effort at the realignment of reading, writing, and power. In this moment, the authors at …

The Bracero Program And The Exploitability Of Migrant Workers, Kayla E. Dantona

Dissertations, Theses, and Capstone Projects

This thesis explores the exploitability of migrants working in the United States. Historically, the United States government has emphasized the economic utility of migrant workers, while ignoring their basic human rights. Policymakers have viewed these people as a disposable work force and seek to control them by generating widespread fear of deportation, racialized segregation, discriminatory treatment, and with the help of governing and policing entities willing to turn a blind eye to these injustices, as long as they continue to profit financially.

This thesis will look at the Bracero Program with a historic lens to exemplify the system of exploitation …

Type Of Glossing Affects Cognitive Load And Retrieval Of Meaning During L2 Reading, Camilo Andrés Bonilla Carvajal

Dissertations, Theses, and Capstone Projects

The use of translation in language teaching has been a source of controversial debate, nevertheless, glossing—and, specifically, interlinear glossing—remains an understudied type of materials, despite having been used by learners and teachers of foreign languages since at least 1000 C.E. (Bata, Gwara & Porter, 1997). In the absence of a comprehensive literature review tracing the history of interlinear glossing, as well as the absence of enough empirical studies addressing the effect of glossing on cognitive effort in language learning, the present work aims at exploring the role of first language glossing in facilitating reading by describing the results of an …

Deconstructing Biopolitical And Performative Modes Of Gender In Spanish Science Fiction, Emma Navarro

Dissertations, Theses, and Capstone Projects

This thesis investigates the distinctly Spanish works of science fiction created by Pedro Almodóvar and Elia Barceló through biopolitical and feminist frameworks. Utilizing the theories of feminist philosopher Judith Butler and sociologist Jemima Repo, we uncover associations between the fictional and theoretical that have seldom been studied in conjunction. The paper aims to demonstrate Almodóvar and Barceló’s unique narratives free from the confines of an unwavering gender stratum while simultaneously revealing the deteriorative effects of gender as a control apparatus. Deeply influenced by the post-Franco Madrid Movida movement, these creators exemplify the feminist ideals emerging from that progressive time, rejecting …

The Numbers Don’T Lie: A Quantitative Examination Of Trauma Outcomes Among Black Homeless Women, Lisa Marie Persad

Dissertations, Theses, and Capstone Projects

Based on the extensive levels of trauma exposure and the need to provide effective mental health treatment for homeless women and their families, this dissertation was conducted to better understand trauma-related psychological distress and associated mental health outcomes among Black homeless women. More specifically, this study’s researcher examined a national sample of homeless women using three theoretical frameworks (Social Determinants of Health, Critical Race Theory, and Intersectionality), conducting a secondary analysis of the Mental Health Client Level-2018 dataset from the Substance Abuse and Mental Health Services Administration (SAMHSA), and employing hierarchical logistic regression modeling to examine the relative impact of …

The Rent Is Too Damn High:The Spatial And Longitudinal Dimensions Of Housing Affordability, Kasey Zapatka

Dissertations, Theses, and Capstone Projects

As the housing affordability crisis intensifies, I content that the spatial and longitudinal aspects of housing affordability are important dimensions of affordability. While much has been written about the sources and drivers of this new housing crisis, I investigate the impact of space, gentrification, and the life course on affordability patterns. I specifically address questions about the (1) role of space in shaping affordability patterns, the (2) impact of gentrification on neighborhood and household affordability, and (3) the trajectory of affordability over the life course. Broadly, I find that neighborhoods that are gentrifying in 2013 see increased affordability in 2019, …

Hands. Words. Mirrors. A Letter To My Mother., Iliana Emilia García

Dissertations, Theses, and Capstone Projects

My capstone project is a memoir of my mother in a letter format, where I tell my mother the story she forgot, who she was, where we were, and where we’re headed. After my mother was diagnosed with Alzheimer's in 2013, my focus on telling my family history shifted from research of the family to recovery. The loss of my mother's insight and recollections prompted a shift in the narrative. She, one of the main characters in my story, became my most important audience. In a photo album approach, I aim to rebuild what seems lost. I am keeping the …

Unlocking Potential: The School-To-Prison Pipeline For Students With Disabilities, Navena F. Chaitoo

Dissertations, Theses, and Capstone Projects

This research uses quasi-experimental, matched sampling to examine the school-to-prison pipeline for students with disabilities using data from the National Longitudinal Study of Adolescent to Adult Health. This study presents novel insights into an at-risk group that has faced disproportionate rates of school discipline and incarceration. The study finds school suspension to be associated with future involvement in the criminal legal system and lower educational attainment. Disability was not found to mediate the relationship between suspension and future involvement in the criminal legal system or the relationship between suspension and academic outcomes. However, disability was found to be a statistically …

Extremism In America: Explaining Variations In Ideologically Motivated Fatal Violence, Celinet Duran

Dissertations, Theses, and Capstone Projects

This dissertation uses data from the United States Extremist Crime Database (ECDB) to assess the nature of extremist violence between left-wing, far-right and al-Qaeda and associated movements (AQAM) inspired ideological fatal violence. It extends the empirical literature on extremist violence in three significant ways by: (1) expanding an existing database to provide a comparative component that is both timely and policy-relevant and conveys a more complete picture of the nature of domestic extremism in the U.S.; (2) systematically comparing extremist violence across the left-wing, far-right and AQAM ideologies to better assess the nuances of extremist violence; and (3) applying empirical …

Diversity Still Matters: School-Level Racial Diversity, Poverty And Performance Of New York City Public Schools, Byunghwa Kim

Dissertations, Theses, and Capstone Projects

During the last few decades, schools in New York City (NYC) have experienced great demographic changes due to the massive influx of various ethnic and racial groups. Although the race and ethnicity makeup of NYC is 42% white, 29% Hispanic or Latino, 24% Black or African American and 14% Asian, 74% of Black and Hispanic students attend a school with less than 10 percent white students, while 34% of white students attend a school with more than half white peers. Also, more than 60% of Hispanic and Black students are attending schools where more than 75% of peer students experience …

Political Theatre After Occupy: Participation, Interpellation, And The Search For New Subjectivities In The Theatre, Andrew J. Goldberg

Dissertations, Theses, and Capstone Projects

The use of audience participation in political theatre has become a common feature of many performances. In this dissertation, I consider the dramaturgies of a number of political theatre performances that have premiered since 2011 and demand various forms of embodied audience engagement to elucidate the potential for theatre to produce a criticality about subjectivity and the processes of subjectivation. Drawing on the recent re-engagement with Althusser’s theory of interpellation by contemporary political theorists, I develop a theory of critical aesthetic interpellation, the strategic and self-reflexive play with the theatrical apparatus to defamiliarize the process of political subjectivation. These …