Digital Commons Network^™

Optimized Peptide Nanomaterials As Delivery Vehicles For Hydrophobic Metal-Based Anticancer Agents, Yaron Marciano

Dissertations, Theses, and Capstone Projects

Enzyme-responsive materials have been well explored, particularly as therapeutic and diagnostic agents. In this thesis we demonstrate that anionic self-assembling peptides can be utilized as delivery vehicles for metal-based hydrophobic payloads. The tunability of the system is highlighted as well as the increase in cytotoxicity and selectivity in vitro. The rapid degradation of peptides in cell media may lead to the formation of new peptide-drug bioconjugates with increased activity and selectivity. The physiological stability of these peptide delivery vehicles has been optimized by capping the N-terminus with an acetyl group. This simple backbone modification was shown to not prevent self-assembly, …

Defining Twice Exceptional Learners: A Study Of Self-Concept, Alyssa D. Landau

Dissertations, Theses, and Capstone Projects

In 2014, the first operational definition of twice exceptional (2e) learners was published in Gifted Child Quarterly to provide a clear and identifiable profile of the population (Reis, Baum, & Burke, 2014). The article defines 2e learners as, “students who demonstrate the potential for high achievement or creative productivity in one or more domains such as math, science, technology, the social arts, the visual, spatial, or performing arts or other areas of human productivity AND who manifest one or more disabilities as defined by federal or state eligibility criteria” (Reis et al., 2014, p. 222-223). Publishing an operational definition of …

Social Identity, Scientific Practice, And The Production Of Social Knowledge: An Ethnographic Investigation Of American Social Psychology Laboratories, Donald V. Brown Jr

Dissertations, Theses, and Capstone Projects

Social identity has the ability to permeate a multitude of domains in everyday life. Therefore, the science of social psychology—influential due to its impact in education, social and public policy, and the law—rightfully foregrounds the presence of social identity categories in the theorizing and empirical work of the discipline. Many researchers consider social identities such as race and gender to be socially constructed categories. This allows researchers to understand these identities in light of their history, complexity, and relationships to each other. However, the practical application and use of social identities as socially constructed “objects of study” is uncommon in …

Kingdoms Becoming: Dialectic Of Black Romanticism, Rasheed M. Hinds

Dissertations, Theses, and Capstone Projects

Kingdoms Becoming emphasizes the profound impact that biblical prophecy, the slave trade, and the American Revolution had on Romanticism, Black nationalism, and horizontal transnationalism. Whereas current scholarship identifies the French Revolution as the seismic shift that inspired British Romanticism and caused a resurgence in prophetic enthusiasm, the American Revolution represents the advent of Black Romanticism and inchoate Black nationalism; this cataclysmic event introduced Afro-British identity, Black Romantic prophecy, and Black nationalist sentiment to the English nation. While many scholars have underscored the ways in which the abolitionist movement informed both British and Black Romanticism and sparked a transnational human-rights movement, …

How The U.S. Mainstream Media Perpetuates Cis White Masculine Hegemony, Yelena Dzhanova

Dissertations, Theses, and Capstone Projects

The news is important because it helps individuals understand their place in the world and make the best decisions for themselves. Throughout its strong history and presence in the United States, the journalism industry has prided itself on delivering fact-based news using an objective framework, meaning that there is an expectation that journalists communicate the news impartially and without bias. Through an examination of gendered language and visual representations published in and by recent mainstream U.S. digital and print media outlets, this paper explains how the media plays a major role in the perpetuation of cis white masculinity. This paper …

Resource Management In Mobile Edge Computing For Compute-Intensive Application, Xiaojie Zhang

Dissertations, Theses, and Capstone Projects

With current and future mobile applications (e.g., healthcare, connected vehicles, and smart grids) becoming increasingly compute-intensive for many mission-critical use cases, the energy and computing capacities of embedded mobile devices are proving to be insufficient to handle all in-device computation. To address the energy and computing shortages of mobile devices, mobile edge computing (MEC) has emerged as a major distributed computing paradigm. Compared to traditional cloud-based computing, MEC integrates network control, distributed computing, and storage to customizable, fast, reliable, and secure edge services that are closer to the user and data sites. However, the diversity of applications and a variety …

Literature, Development, And The Reaches Of Literacy, 1979 To The Present, Stephen Tremaine

Dissertations, Theses, and Capstone Projects

In this study, I examine the twentieth century’s vast history of large-scale literacy campaigns and the imprints and legacies of those campaigns in literary texts from the global South. Literary texts by Mahasweta Devi, Nuruddin Farah, J. M. Coetzee, M. G. Vassanji, Abdulrazak Gurnah, and others provide compelling examples of narratives that foreground literacy - particularly its acquisition, loss, or redistribution in the lives, communities, and emerging independent nations in which these narratives take place. The second half of the twentieth century represents a global effort at the realignment of reading, writing, and power. In this moment, the authors at …

Synthesis Of Fluoroorganics And Applications Of Novel Fluorinated Building Blocks, Wei Wei

Dissertations, Theses, and Capstone Projects

Diastereoselectivity of fluorination of a carbanion alpha to a sulfone in enantiomerically pure N-Boc protected (R)- and (S)-2,2-dimethyl-4-((arylsulfonyl)methyl)oxazolidines has been studied. Fluorination proceeded with good to excellent diastereoselectivity, which was base-dependent and was highest with lithium diisopropylamide (LDA). Diastereoselectivity also depended on the aryl moiety of the aryl sulfone and was highest with benzothiazole-derived sulfones. Under basic conditions, epimerization at the C–F stereogenic center alpha to the sulfone has been achieved for the first time and proceeded with good to excellent diastereoselectivity, which was highest in the case of a benzothiazole sulfone and with a lithium base. …

The Rent Is Too Damn High:The Spatial And Longitudinal Dimensions Of Housing Affordability, Kasey Zapatka

Dissertations, Theses, and Capstone Projects

As the housing affordability crisis intensifies, I content that the spatial and longitudinal aspects of housing affordability are important dimensions of affordability. While much has been written about the sources and drivers of this new housing crisis, I investigate the impact of space, gentrification, and the life course on affordability patterns. I specifically address questions about the (1) role of space in shaping affordability patterns, the (2) impact of gentrification on neighborhood and household affordability, and (3) the trajectory of affordability over the life course. Broadly, I find that neighborhoods that are gentrifying in 2013 see increased affordability in 2019, …

Examining Factors Related To Tobacco Treatment Engagement Among Tobacco Dependent Black/African American; Hispanic/Latino Cancer Patients: An Analysis Of Memorial Sloan Kettering Cancer Center’S Tobacco Treatment Program, Gleneara E. Bates-Pappas

Dissertations, Theses, and Capstone Projects

Among patients diagnosed with cancer, persistent tobacco use is associated with adverse clinical outcomes such as worse treatment side effects, decreased effectiveness of cancer treatment (chemotherapy, radiotherapy, and surgery), all increasing risk of recurrence, second primary cancers, and poor survival. Despite the clinical importance of tobacco cessation in the context of high quality cancer care, engaging Black/African American and Hispanic/Latino cancer patients in tobacco treatment programs can be challenging. Prior studies with the general adult population demonstrate that Black/African American and Hispanic/Latino smokers are referred to and accept tobacco cessation treatment at lower rates compared to non-Hispanic White smokers. This …

Deconstructing Biopolitical And Performative Modes Of Gender In Spanish Science Fiction, Emma Navarro

Dissertations, Theses, and Capstone Projects

This thesis investigates the distinctly Spanish works of science fiction created by Pedro Almodóvar and Elia Barceló through biopolitical and feminist frameworks. Utilizing the theories of feminist philosopher Judith Butler and sociologist Jemima Repo, we uncover associations between the fictional and theoretical that have seldom been studied in conjunction. The paper aims to demonstrate Almodóvar and Barceló’s unique narratives free from the confines of an unwavering gender stratum while simultaneously revealing the deteriorative effects of gender as a control apparatus. Deeply influenced by the post-Franco Madrid Movida movement, these creators exemplify the feminist ideals emerging from that progressive time, rejecting …

Hands. Words. Mirrors. A Letter To My Mother., Iliana Emilia García

Dissertations, Theses, and Capstone Projects

My capstone project is a memoir of my mother in a letter format, where I tell my mother the story she forgot, who she was, where we were, and where we’re headed. After my mother was diagnosed with Alzheimer's in 2013, my focus on telling my family history shifted from research of the family to recovery. The loss of my mother's insight and recollections prompted a shift in the narrative. She, one of the main characters in my story, became my most important audience. In a photo album approach, I aim to rebuild what seems lost. I am keeping the …

Unlocking Potential: The School-To-Prison Pipeline For Students With Disabilities, Navena F. Chaitoo

Dissertations, Theses, and Capstone Projects

This research uses quasi-experimental, matched sampling to examine the school-to-prison pipeline for students with disabilities using data from the National Longitudinal Study of Adolescent to Adult Health. This study presents novel insights into an at-risk group that has faced disproportionate rates of school discipline and incarceration. The study finds school suspension to be associated with future involvement in the criminal legal system and lower educational attainment. Disability was not found to mediate the relationship between suspension and future involvement in the criminal legal system or the relationship between suspension and academic outcomes. However, disability was found to be a statistically …

Environmental Drivers Of Dispersal In Black-And-White Ruffed Lemurs (Varecia Variegata), Amanda Mancini

Dissertations, Theses, and Capstone Projects

Dispersal is a fundamental aspect of primates’ lives, influencing population connectivity through gene flow, driving community structure and assembly, and having important consequences for adaptation and speciation. Primates disperse within an environmental context, with both intervening and local environmental factors affecting the motivation, capacity, timing, and success of dispersal at all phases. Direct evaluations of primate dispersal are challenging given the rarity of dispersal events and the large distances that animals often settle from their departure site, therefore indirect measures– such as the use of population genetic data– are more common.

The field of landscape genetics enables researchers to combine …

A Stronger Strong Schottky Lemma For Euclidean Buildings, Michael E. Ferguson

Dissertations, Theses, and Capstone Projects

We provide a criterion for two hyperbolic isometries of a Euclidean building to generate a free group of rank two. In particular, we extend the application of a Strong Schottky Lemma to buildings given by Alperin, Farb and Noskov. We then use this extension to obtain an infinite family of matrices that generate a free group of rank two. In doing so, we also introduce an algorithm that terminates in finite time if the lemma is applicable for pairs of certain kinds of matrices acting on the Euclidean building for the special linear group over certain discretely valued fields.

The Impact Of Overseas Study Experiences On Chinese Students’ Attitudes Toward The United States, Xufeng Fang

Dissertations, Theses, and Capstone Projects

The extent to which overseas study experiences increase Chinese students’ positive attitude toward the United States has triggered debates because of Chinese government’ overwhelming influence on Chinese students studying overseas, the instability of U.S.-China relations and the especially complex characteristics of Chinese students’ attitudes themselves. I will use value theory, belief system theory, and self-categorization theory to explain the unstable character of these attitudes, and the important roles of values and identity that determine attitudes’ change. After making three key hypotheses based on these theories, this paper conducts a survey on three groups of Chinese students both in China and …

Diversity Still Matters: School-Level Racial Diversity, Poverty And Performance Of New York City Public Schools, Byunghwa Kim

Dissertations, Theses, and Capstone Projects

During the last few decades, schools in New York City (NYC) have experienced great demographic changes due to the massive influx of various ethnic and racial groups. Although the race and ethnicity makeup of NYC is 42% white, 29% Hispanic or Latino, 24% Black or African American and 14% Asian, 74% of Black and Hispanic students attend a school with less than 10 percent white students, while 34% of white students attend a school with more than half white peers. Also, more than 60% of Hispanic and Black students are attending schools where more than 75% of peer students experience …

Tgf-B Signaling Mechanisms In Caenorhabditis Elegans Response To Bacterial Pathogens, Emma J. Ciccarelli

Dissertations, Theses, and Capstone Projects

When exposed to infection, the nematode C. elegans mounts an innate immune response through secretion of antimicrobial peptides (AMPs). Different signaling pathways in the worm regulate release of these AMPs. One highly conserved pathway is the C. elegans BMP like pathway – regulated by the ligand DBL-1. The DBL-1 pathway is noted for its significant role in development but has also been shown to regulate many post-developmental processes within the worm, including the immune response. We are interested in determining how DBL-1 signaling can mediate a response specific to immunity, separate from its other functions in the worm. Through survival …

Chromatic Dissensus: An Otherwise Archive Of Natural Dyes, 1700–1856, Luke Church

Dissertations, Theses, and Capstone Projects

Chromatic Dissensus: An Otherwise Archive of Natural Dyes, 1750-1856 works from the premise that the absences regarding subaltern life structuring the colonial archive are an epistemological problem—that is, navigating the colonial archive requires an interrogation of the parameters and practices of knowledge formation. Building from recent scholarship in early American studies which details how eighteenth-century colonial knowledge developed out of an epistemic entanglement between British colonists, diasporic Africans, and indigenous Americans, my dissertation queries the overdetermination of colonial knowledge and subsequent occlusion of alternative parameters for knowing. Enlisting aesthetics, in its broad definition as the theorization of sense making, my …

Police Academy Attrition Rates: A Long-Term Analysis Of Female Candidates In California, Texas, Wisconsin, Arizona, And New Jersey, Shamus W. Smith

Dissertations, Theses, and Capstone Projects

Police agencies throughout the country still have an underrepresentation of women police officers. Research has shown that the benefits of hiring women police officers are many, as they have proven to be as competent as their male counterparts, less likely to use excessive force, can implement community-oriented policing, respond to calls for domestic violence effectively, bring about beneficial changes in policy for all agencies, and reduce the problems of sexual discrimination and harassment within an agency. Yet, the obstacles encountered for women are significantly different from their male counterparts. As such, this research uses secondary, non-identifiable data obtained from police …

Examination Of Korean Feminism From The Intersections Of Colonialism, Modernity, And Nationalism In Colonial Korea (1910–1945), Yae Hee Choi

Dissertations, Theses, and Capstone Projects

This thesis aims to investigate the politics of Korean feminism during the time of Japanese colonization (1910-1945) from the perspectives of colonialism, modernity, and nationalism. The study illustrates how Korean women perceived themselves in terms of individuals, colonial subjects, and Korean nationals during a period of significant societal changes. It also intends to broaden the boundaries of gender inquiries in colonial Korea, which often focus on binary constructions of Japanese repression versus national resistance. This study argues that a nationalist paradigm oversimplifies the intricate dynamics and varied experiences of colonized subjects, specifically women. The logic of nationalism places all forms …

Storytelling In Modernist Fiction: A “Method Of Presence”, Laura Malhotra

Dissertations, Theses, and Capstone Projects

This dissertation explores the relationship between narrative modes in cinema and literature and adopts the lineage laid out by Lukács that connects the oral tradition and epic poetry to the novel. I attach art cinema to this lineage and seek to justify its position as an equally significant medium representative of the age in which it is produced. This study aims to correct one established view of film, put forth by the Frankfurt School, of its low value as an art form and as a site of meaning. I compare the birth of literary modernism in Britain to the emergence …

Indigenous Performances In Contemporary Indian Urban Public Theatres: Coloniality, Globalization, And The State, Mayurakshi Sen

Dissertations, Theses, and Capstone Projects

Indigenous Performances in Contemporary Indian Urban Public Theatres: Coloniality, Globalization, and the State examines the aesthetic and political dimensions of contemporary public theatres in the major Indian cities of Kolkata, Mumbai, and Delhi, with a special focus on the utilization of India’s indigenous precolonial (or extra-colonial) classical, regional, and folk performance forms, elements, and repertoires in such urban practice. Through dramaturgical, ethnographic, and archival analyses, this dissertation studies significant contemporary productions from representative urban Indian theatre groups, including Nandikar, Rangakarmee, and Padatik in Kolkata; the Indian People’s Theatre Association, Mumbai, Ekjute, and Rangshila in Mumbai; and Circle Theatre Company and …

American Eel (Anguilla Rostrata) And Other Fishes As Surveyed By Environmental Dna In The Bronx River And Hudson River Watershed, Sam C. Chin

Dissertations, Theses, and Capstone Projects

Mounting an effective response to the threats faced by freshwater fish may require expansions to aquatic biomonitoring in excess of what is feasible using the capture-based survey techniques currently relied upon by natural resource managers. Methods for analyzing environmental DNA (eDNA) are emerging as a minimally invasive and cost-effective approach for surveying fish and other organisms. By detecting taxon-specific DNA sequences recovered from environmental samples (e.g. water, sediment), eDNA methods are able to infer species presence from samples that can be collected rapidly with simple equipment. In many cases, eDNA detection rates of fish species have been shown to meet …

Mediated Locality: Assembling The Independent Music Scene In Brooklyn, New York, Frank Meegan

Dissertations, Theses, and Capstone Projects

This dissertation investigates how independent musicians, concert organizers, and other scene participants in Brooklyn, New York use digital technology and new media in their artistic practice. It is based on three years of participant observation in Brooklyn from 2016 to 2019, where I attended events at small venues like bars and DIY spaces, and interviewed musicians, concert organizers, independent label runners, and other scene participants. I also observed the online activity of musicians and organizers on public Facebook, Instagram, and Bandcamp pages. I argue that Brooklyn independent musicians use digital media, and are themselves mediated, as their activities at physical …

Dynamics In Designed Elastins And Enzymes, Jonathan M. Preston

Dissertations, Theses, and Capstone Projects

In this dissertation I present experimental results on the structure and dynamics of elastin, an elastomeric extracellular component in vertebrates that, in mammals, provides structure and elasticity to the circulatory system, lungs, skin and joints. These experiments, using a set of designed elastin like proteins with properties analogous to the natural protein, show that elastin is highly disordered and connect this disorder to its mechanism of assembly and elasticity. In addition, I also present preliminary work on imparting flexibility into a set of computationally designed metalloenzymes to broaden the range of catalytic activities they perform.

Synthesis And Analysis Of Novel Troponoid-Based Chemical Probes, Alex Berkowitz

Dissertations, Theses, and Capstone Projects

Troponoids are a class of non-benzenoid aromatic species featuring a cycloheptatrienone ring and varying degrees of oxygenation. These scaffolds have proven ubiquitous amongst natural products, and have displayed promise as therapeutic agents against a variety of diseases. Herein, we will describe our efforts towards furthering troponoids as potential pharmaceuticals. In Chapter 1, we outline a kojic acid-derived oxidopyrylium cycloaddition/ring-opening method developed in our lab to generate ahydroxytropolones (aHTs). This route was successfully adapted to synthesize a small library of lipophilic aHTs that were proven to be effective against herpes simplex virus-1 (HSV-1) replication, while providing further insight into the mechanism …

Pleasure And Power In A Cover Culture: Audiences, Musicians, And Venues In İZmi̇R’S Popular Music Scene, Yılmaz Onur Sönmez

Dissertations, Theses, and Capstone Projects

The live popular music scene in İzmir, Turkey, is dominated by slow-changing cover repertoires that are performed by musicians who have been on stage for a few decades, at places that have been hosting covers shows for a prolonged time. In this dissertation, I question the reasons behind this practice, which I call cover culture, and analyze it from the three different but interrelated perspectives of audiences, musicians, and venues. My analysis relies on the fieldwork data I collected between March 2019 and May 2022, and on my long-term involvement with and observations of the scene since the early 2000s. …

Examining Past, Present, And Future Of Agricultural Labor: From The Bracero Program To The Coalition Of Immokalee Workers, Francesca Paradiso

Dissertations, Theses, and Capstone Projects

This thesis is a comparative study that examines the Bracero Program and the work of the Coalition of Immokalee Workers (CIW). The Bracero Program brought Mexican workers into the United States on temporary work visas from 1942-1964. The CIW is an organization of Mexican workers that was founded in 1992 as a response to the horrible working conditions that Mexican tomato pickers faced in Immokalee, Florida. In this thesis, I show that by putting these programs side by side, we can see the exploitation of Mexican farmworkers has relied on changing government tools—different forms of visas, different immigration regimes, different …

Exploring The Barriers And Facilitators Of Puerto Rican Women Senior Leadership In New York City Nonprofit Social Service Organizations, Emily Lopez

Dissertations, Theses, and Capstone Projects

Puerto Rican women in senior leadership positions within nonprofit organizations contribute to the direction and governance of many New York City agencies. The findings in this research bring attention to their experiences and grit in the sector. According to Smith and Nkomo (2022) grit gives women of color in leadership the ability to bounce back after being discouraged and sidelined in their careers or to survive in hypermasculine cultures. Grit is defined as women who lead with passion, perseverance and know who they are (Smith & Nkomo, 2022). This study explores barriers and facilitators encountered by Puerto Rican women who …