Digital Commons Network^™

Frequent First-Trimester Pregnancy Loss In Rhesus Macaques Infected With African-Lineage Zika Virus, Jenna R. Rosinski, Kevin K. Noguchi, Et Al.

2020-Current year OA Pubs

In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infections. Given high human immunodeficiency virus (HIV) burdens in regions where African-lineage ZIKV circulates, we evaluated whether pregnant rhesus macaques infected with simian immunodeficiency virus (SIV) have a higher risk of African-lineage ZIKV-associated birth defects. Remarkably, in both SIV+ and SIV- animals, ZIKV infection early in the first trimester caused a high incidence (78%) of spontaneous pregnancy loss within 20 days. These findings suggest …

Selective Dorsal Rhizotomy For Treatment Of Spasticity After Hemispherectomy In Children: A Case Report, Ts Park, Susan Joh, Matthew D. Smyth, Nicole L. Meyer, Deanna M. Walter

2020-Current year OA Pubs

Performing a hemispherotomy or hemispherectomy is known to treat medically intractable epilepsy successfully, yet contralateral hemiparesis and increased muscle tone follow the epilepsy surgery. Spasticity and coexisting dystonia presumably cause the increased muscle tone in the lower extremity on the opposite side of epilepsy surgery. However, the extent of the role of spasticity and dystonia in high muscle tone is unknown. A selective dorsal rhizotomy is performed to reduce spasticity. If a selective dorsal rhizotomy is performed in the affected patient and muscle tone is reduced, the high muscle tone is not due to dystonia. Two children, who previously underwent …

Design Of Serena-6, A Phase Iii Switching Trial Of Camizestrant In Esr1-Mutant Breast Cancer During First-Line Treatment, Nicholas Turner, Cynthia Huang-Bartlett, Kevin Kalinsky, Massimo Cristofanilli, Giampaolo Bianchini, Stephen Chia, Hiroji Iwata, Wolfgang Janni, Cynthia X Ma, Erica L Mayer, Yeon Hee Park, Steven Fox, Xiaochun Liu, Sasha Mcclain, Francois-Clement Bidard

2020-Current year OA Pubs

No abstract provided.

Building The Foundation For A Community-Generated National Research Blueprint For Inherited Bleeding Disorders: Research Priorities For Mucocutaneous Bleeding Disorders, Robert F Sidonio Jr, Jorge Di Paola, Et Al.

2020-Current year OA Pubs

BACKGROUND: Excessive or abnormal mucocutaneous bleeding (MCB) may impact all aspects of the physical and psychosocial wellbeing of those who live with it (PWMCB). The evidence base for the optimal diagnosis and management of disorders such as inherited platelet disorders, hereditary hemorrhagic telangiectasia (HHT), hypermobility spectrum disorders (HSD), Ehlers-Danlos syndromes (EDS), and von Willebrand disease (VWD) remains thin with enormous potential for targeted research.

RESEARCH DESIGN AND METHODS: National Hemophilia Foundation and American Thrombosis and Hemostasis Network initiated the development of a National Research Blueprint for Inherited Bleeding Disorders with extensive all-stakeholder consultations to identify the priorities of people with …

Effect Of Fecal Microbial Transplantation On Clostridioides Difficile Infection: Dysbiosis, Metabolites And Health Related Quality Of Life, Kevin W Garey, Paul Feuerstadt, Erik R Dubberke, Amy Guo, Glenn S Tillotson

2020-Current year OA Pubs

No abstract provided.

Can Breaking Heroin Addiction Lead To A Broken Heart? A Case Of Reverse Takotsubo Cardiomyopathy In A Patient With Heroin Withdrawal, Hunter Launer, Daniel Nelson, Alarica Dietzen, Atul Singla

The Texas Heart Institute Journal

Reverse takotsubo cardiomyopathy is triggered by emotional or physical stress and has a presentation similar to that of acute coronary syndrome. A 39-year-old woman with a history of heroin use disorder presented with intractable nausea, vomiting, and diarrhea. She was diagnosed with heroin withdrawal and started on buprenorphine-naloxone. On day 2 of her hospitalization, she developed chest heaviness and had an elevated troponin I level of 3.2 ng/mL (reference range, 0.015-0.045 ng/mL); electrocardiography showed new T-wave inversions in the anterior and inferior leads. Emergent coronary angiography showed patent coronary arteries, and left ventriculography showed basal hypokinesis and apical hyperkinesis, consistent …

Glioma Epileptiform Activity And Progression Are Driven By Igsf3-Mediated Potassium Dysregulation, Brittney Lozzi, Yeunjung Ko, Malcolm Ford Mcdonald, Anna Rosenbaum, Alexis Cervantes, Emmet Huang-Hobbs, Carolina Cocito, Jeffrey Peter Greenfield, Ali Jalali, Jay Gavvala, Carrie Mohila, Akdes Serin Harmanci, Jeffrey Noebels, Ganesh Rao, Benjamin Deneen

Faculty, Staff and Students Publications

Seizures are a frequent pathophysiological feature of malignant glioma. Recent studies implicate peritumoral synaptic dysregulation as a driver of brain hyperactivity and tumor progression; however, the molecular mechanisms that govern these phenomena remain elusive. Using scRNA-seq and intraoperative patient ECoG recordings, we show that tumors from seizure patients are enriched for gene signatures regulating synapse formation. Employing a human-to-mouse in vivo functionalization pipeline to screen these genes, we identify IGSF3 as a mediator of glioma progression and dysregulated neural circuitry that manifests as spreading depolarization (SD). Mechanistically, we discover that IGSF3 interacts with Kir4.1 to suppress potassium buffering and found …

A Randomized, Controlled Phase 1b Trial Of The Sm-Tsp-2 Vaccine For Intestinal Schistosomiasis In Healthy Brazilian Adults Living In An Endemic Area, Frederico Talles, Marcella Rezende Silva, Shital M Patel, Shirley Galbiati, Jessie K Kennedy, Jordan S Lundeen, Maria Flavia Gazzinelli, Guangzhao Li, Lara Hoeweler, Gregory A Deye, Maria Elena Bottazzi, Peter J Hotez, Hana M El Sahly, Wendy A Keitel, Jeffrey Bethony, Robert L Atmar

Faculty, Staff and Students Publications

BACKGROUND: Recombinant Schistosoma mansoni Tetraspanin-2 formulated on Alhydrogel (Sm-TSP-2/Alhydrogel) is being developed to prevent intestinal and hepatic disease caused by S. mansoni. The tegumentary Sm-TSP-2 antigen was selected based on its unique recognition by cytophilic antibodies in putatively immune individuals living in areas of ongoing S. mansoni transmission in Brazil, and preclinical studies in which vaccination with Sm-TSP-2 protected mice following infection challenge.

METHODS: A randomized, observer-blind, controlled, Phase 1b clinical trial was conducted in 60 healthy adults living in a region of Brazil with ongoing S. mansoni transmission. In each cohort of 20 participants, 16 were randomized to receive …

Electrical Stimulation To Regain Lower Extremity Muscle Perfusion And Endurance In Patients With Post-Acute Sequelae Of Sars Cov-2: A Randomized Controlled Trial, Areli Flores-Camargo, Gil Spitz, M G Finco, Amir Behzad Bagheri, Dipaben Modi, Fidaa Shaib, Bijan Najafi

Faculty, Staff and Students Publications

Muscle deconditioning and impaired vascular function in the lower extremities (LE) are among the long‐term symptoms experienced by COVID‐19 patients with a history of severe illness. These symptoms are part of the post‐acute sequelae of Sars‐CoV‐2 (PASC) and currently lack evidence‐based treatment. To investigate the efficacy of lower extremity electrical stimulation (E‐Stim) in addressing PASC‐related muscle deconditioning, we conducted a double‐blinded randomized controlled trial. Eighteen (n = 18) patients with LE muscle deconditioning were randomly assigned to either the intervention (IG) or the control (CG) group, resulting in 36 LE being assessed. Both groups received daily 1 h E‐Stim …

Academic Performance Of Low Ses At-Risk Black And Latinx Students: A Case Study Of Teachers’ Perceptions, Shelly Lynn Anderson

Electronic Theses and Dissertations

This study determined the perspective of the teacher when researching low SES at-risk Black and Latinx students’ academic performance. Research, over the years, not only highlight reasons and evidence for the low academic performance and the struggles the low SES at-risk Black and Latinx students face. In addition, research also recommends educational interventions that are not effective in bridging the achievement gap of low SES at-risk Black and Latinx students in comparison to their wealthier, White counterparts. Previous research denotes that school districts desire to implement educational interventions for struggling learners; however, theories, strategies, and interventions often do not translate …

A Multiple Case Study: The Impact Of Instructional Coaching On Novice Teachers, Misti N Tope

Electronic Theses and Dissertations

This study addressed the problem of retention for novice teachers in struggling schools. The purpose of this qualitative multiple case study was to provide insight into the support instructional coaches provide novice teachers in an urban school district. School administrators have worked to determine the best method for utilizing their instructional coach to improve instructional practices and increase novice teacher retention. Data were collected using structured interviews with instructional leadership team members and their novice teachers. Three research sites were used, including one elementary, middle, and high school in an Oklahoma large urban school district. Findings indicated that good instructional …

Speech-Language Pathologists’ Barriers To Providing Services To The Deaf And Hard Of Hearing Children Ages 2–9, Irene S. García-Benavides

Electronic Theses and Dissertations

This qualitative case study explored the knowledge and experiences of 12 speech-language pathologists (SLPs) regarding the culture and linguistic processes of the Deaf culture when assessing and treating deaf and hard of hearing children ages 2 to 9. Data analysis has resulted in identification of the following main themes: (a) The Scope of Practice, (b) Barriers Regarding Culturally and Linguistically Informed Practices, and (c) Awareness of Similarities and Differences in Language Acquisition and Structures in English and American Sign Language (ASL). The findings of this study underscored the importance of knowledge that SLPs have to acquire in order to provide …

Venous Leg Ulcers: An Analysis Of Nursing Knowledge, Shelia Moore-Miller

Electronic Theses and Dissertations

This project evaluated the knowledge level of wound center nursing staff on venous leg ulcer etiology and treatments after an educational intervention. To determine the effectiveness of the educational intervention, participants completed a pretest and posttest evaluation. Venous leg ulcers (VLUs) are chronic lower extremity ulcers affecting older Americans. VLUs are painful and negatively affect activities of daily living. Inadequate VLU treatment can become an infectious process that can ultimately threaten limb existence. A quantitative, quasi-experimental study was conducted over three weeks in a hospital-based wound care center in central Florida. The theoretical framework applied to this project is Lydia …

Burnout In Medical Assistants In Primary Care: Can Mindfulness Be A Solution?, Natalee D. Calais

Electronic Theses and Dissertations

Burnout is described as feelings associated with emotional exhaustion, depersonalization of patients, and a loss of sense of personal accomplishment and it is unique to healthcare workers. Current research highlights this condition among physicians, nurses, and mid-level providers; however, insufficient research exists regarding the effects of burnout on medical assistants. Research led to mindfulness as a possible solution defined as an intentional regulation of attention and awareness of the present moment. This project sought to see if mindfulness practices could be utilized to mitigate the effects of burnout in medical assistants. It was hypothesized that mindfulness could be a solution. …

The Development Of The Protocol For Advancing Inclusive Teaching Efforts (Paite), Tracie M. Addy, Hamna Younas, Pelin Cetin, Fatimata Cham, Monica Rizk, Chidiebere Nwankpa, Manuela Borzone

Journal of Educational Research and Practice

Inclusive teaching is instruction that fosters a sense of belonging, is equitable for a diverse student body, and shows students that they matter. Inclusivity is associated with positive student outcomes and is critical at institutions of higher education given the diversity of student populations. While there are a number of recommended practices for inclusive teaching, valid and reliable classroom observation tools that provide instructors with formative feedback on their instructional efforts are lacking. This article describes the development of the Protocol for Advancing Inclusive Teaching Efforts (PAITE). The PAITE was developed for formative purposes to provide higher education instructors with …

Canvas Outcomes For Assessment Data Collection, Virginia Kelsey, Sadie Glass

Pacific's Annual Assessment Conference

No abstract provided.

Nurses’ Emotional Intelligence, Behavior And The Mediating Role Of Job Stress In Lebanon, Suzan S. Al Kadi, Abdul Rahman Beydoun, Alaaeldine A. Ali

BAU Journal - Society, Culture and Human Behavior

The aim of this paper is to examine the influence of emotional intelligence, namely self-awareness, self-management, social awareness and management’s relationship on the nurse’s behavior within the Lebanese context. It specifically examines the indirect effect of the nurses’ EI and its sub skills on behavior, exit, voice, loyalty, neglect, through the mediating role of job stress. A total sample of subjects consisted of 365 registered nurses actively working in the Lebanese hospitals during the COVID 19 period. Mediation was tested using Baron and Kenny (1986)’s framework. The findings demonstrate that the EI elements (Self-awareness, self-management, social awareness and management’s relationship) …

Shaping Millennials’ Attitudes Towards Luxury Brands In International Cities: The Case Of Abu Dhabi, Zeina Mazloum

BAU Journal - Society, Culture and Human Behavior

This study aims to investigate the impact of two intrinsic motives (perceived self-identity and perceived self- status) and two other extrinsic motives (celebrities and social media presence) on millennials' attitudes towards luxury brands; ultimately reflecting on their buying intention. Illustrated through a conceptual framework model, results reveal that intrinsic motives strongly influence millennials' attitudes while extrinsic motives slightly influence their attitudes towards luxury brands; both resulting in molding millennials' buying intention correspondingly.

Rights Of Persons With Disabilities In India: Provisions, Promises And Reality, Triveni Goswami Vernal

BAU Journal - Society, Culture and Human Behavior

The paper Rights of Persons with Disabilities in India: Provisions, Promises and Reality traces the historical evolution of the disability related legal provisions in India briefly, in the context of the United Nations mandated Declaration on the Rights of Disabled Persons (1975) and the Convention on the Rights of the Persons with Disabilities (CRPD,2007). In such a scenario, the paper attempts to arrive at an understanding of the extent to which the provisions have been implemented. To this extent, the researcher conducted a series of telephonic interviews with several parent-advocates who have been vocal about disability rights in India. An …

A Two-Way Traffic Between Psychology And Human Rights, Mayssah El Nayal, Mona G. Sayegh

BAU Journal - Society, Culture and Human Behavior

The World Health Organization (WHO) defines health as a state of complete physical, mental and social well-being and not simply the absence of ailment or infirmity, and mental health as a state of well-being in which the individual is aware of his or her own abilities and is able to contribute to his or her community. On the other hand, the Universal Declaration of Human Rights (UDHR) declares that everyone has the right to a standard of living suitable for the health and well-being of himself and of his family. Therefore, mental health is a right and is protected by …

In The Shadow Of Supply Chains: The Eu Draft Due Diligence Directive, Corporate Enslavement, And The Case For The Inclusion Of Corporate Reparations, Simone Haines

DePaul Journal for Social Justice

No abstract provided.

Illinois: A State-Of-The-Art Model For State Immigration Rulemaking, Camilla Mroczkowski

DePaul Journal for Social Justice

No abstract provided.

Outdated, Archaic, And Stereotypical: Current Medicaid Income And Asset Limits Discriminate Against Working Individuals With Disabilities, Megan Parker

DePaul Journal for Social Justice

No abstract provided.

A Guide To Writing Quality Case Reports, Robert Chait, Graig Donini, Michael G. Flynn

HCA Healthcare Journal of Medicine

Case reports play an essential role in the dissemination of knowledge in medicine. A published case is typically an unusual or unexpected presentation in which the outcomes, clinical course, and prognosis are linked to a literature review in order to place the case into the appropriate context. Case reports are a good option for new writers to generate scholarly output. This article can serve as a template for writing a case report, which includes instructions for creating the abstract and crafting the body of the case report—introduction, case presentation, and discussion. Instructions for writing an effective cover letter to the …

Supersensitivity Psychosis With Acute Dystonia, Tatiana Nunez, Gabriella Meyerson, Mays Alani, Shahid Elahi, Enrique Vargas

HCA Healthcare Journal of Medicine

Introduction

Supersensitivity psychosis is a phenomenon that occurs with chronic usage of antipsychotics secondary to treatment resistance. At this time, there are no standardized guidelines regarding the management of supersensitivity psychosis.

Case Presentation

We present a case of a patient with schizoaffective disorder who developed supersensitivity psychosis and acute dystonia in response to discontinuing psychotropic medications, including high-dose quetiapine and olanzapine. The patient presented with excessive anxiety, paranoia, bizarre thoughts, and generalized dystonia affecting the face, trunk, and extremities. We treated the patient with olanzapine, valproic acid, and diazepam, which alleviated the psychosis back to baseline and significantly improved the …

Juvenile-Type Granulosa Cell Tumor In Pregnancy Presenting As A Ruptured Abdominal Mass, Odinaka Mogor, Steven Feinstein, Glen Friedman, Jose Salvador Saldivar, Melissa Mendez

HCA Healthcare Journal of Medicine

Introduction

Granulosa cell tumors (GCTs) are part of the sex cord-stromal tumors occurring with a rare incidence rate that only makes up about 2-5% of all ovarian malignancies.

Case Presentation

A 28-year-old woman, gravida 2, para 1, presented with a juvenile-type granulosa cell tumor at 31 weeks gestation, which appeared as a rapidly growing mass with rupture. She underwent an exploratory laparotomy with unilateral salpingo-oophorectomy, and consequently had a successful vaginal delivery. Post-operatively she was treated with paclitaxel and carboplatin chemotherapy regimen with no evidence of recurrence after one year.

Conclusion

Radical surgical management is recommended for these tumors due …

Calciphylaxis, A Case Series: The Importance Of Early Detection, Nikita Sijapati, Suy Sen Hung Fong, Omar Ansari, Subhasis Misra, Edgar Mercado, My Myers, Vijay Narasimha

HCA Healthcare Journal of Medicine

Introduction

Calciphylaxis is a rare disorder that involves the formation of cutaneous, subcutaneous, and vascular calcifications. Although it is predominantly seen in patients with end-stage renal disease (ESRD), it has also been reported in patients without chronic kidney disease. The presence of multiple risk factors, a poorly understood mechanism, high mortality, and the lack of standardized treatment make calciphylaxis an important subject.

Case Presentation

We describe the clinical presentation, disease course, and management of 3 patients with calciphylaxis and also provide a literature review. In all 3 patients, the diagnosis was confirmed histologically, and the management involved the continuation of …

Best Practices For Improving Blended Learning In Nigeria: Critical Reflections On The Breast Cancer Clinical Pathway Development Course, Peace I. Egharevba, Kelechi Eguzo, Enyichukwu M. Anya, Nuhu Tumba, Kingsley Nnah, Chukwuemeka Oluoha, Precious Mbaraonye

Journal of Graduate Education Research

Although cancer clinical pathways (CPs) are standardized care plans for the treatment of specific cancers, they are not commonly used in Nigerian hospitals. Many Nigerian clinicians do not have the requisite skill for developing and implementing the use of CPs. Critical reflections provide an important perspective in the philosophy, design, implementation, and outcome of interventions. This paper critically reflects on the design and implementation of a multidisciplinary, blended learning (i.e. online and in-person) course which sought to improve the competence of local doctors, nurses, and allied students in developing clinical pathways. Reflective feedback was obtained from a mix of project …

Tracing East Asian Librarianship In Correspondence: A Data Analysis Of Eastlib Messages From 1995 To 2020, Tang Li, Junjiro Nakatomi, Xiang Li

Journal of East Asian Libraries

The Eastlib listserv, established by the Council on East Asian Libraries (CEAL) as its official mailing list in the early 1990s and hosted at the University of North Carolina, Chapel Hill until the end of May 2022, has been the primary communication channel for East Asian librarians in North America for nearly 30 years. In 1999, Eastlib’s functionality was enhanced to allow its subscribers and the general public to browse and search through email discussions online. However, due to unanticipated system setting changes, it was discovered in March 2020 that access to the online Eastlib archive was limited to postings …

Lists Of Selected Full-Text Databases By Subscription In East Asian Studies, Dongyun Ni, Michiko Ito, Ellie Kim, Anlin Yang

Journal of East Asian Libraries

No abstract provided.