Digital Commons Network^™

The Microbiome And Its Impact On Allogeneic Hematopoietic Cell Transplantation, Florent Malard, Robert R Jenq

Faculty, Staff and Student Publications

Allogeneic hematopoietic cell transplantation (alloHCT) is a standard curative therapy for a variety of benign and malignant hematological diseases. Previously, patients who underwent alloHCT were at high risk for complications with potentially life-threatening toxicities, including a variety of opportunistic infections as well as acute and chronic manifestations of graft-versus-host disease (GVHD), where the transplanted immune system can produce inflammatory damage to the patient. With recent advances, including newer conditioning regimens, advances in viral and fungal infection prophylaxis, and novel GVHD prophylactic and treatment strategies, improvements in clinical outcomes have steadily improved. One modality with great potential that has yet to …

Adding The X-Ray Bragg Reflection Physical Process In Crystal To The Geant4 Monte Carlo Simulation Toolkit, Part I: Reflection From A Crystal Slab, Fada Guan, Makoto Asai, Dirk A Bartkoski, Michael Kleckner, Ze'ev Harel

Faculty, Staff and Student Publications

X-ray diffraction from a solid crystal shows the wave nature of photons. It is an important electromagnetic (EM) physics process when X-ray photons interact with a crystal. Bragg diffraction, often called Bragg reflection, is a special case of the general form of X-ray diffraction, known as Laue diffraction. When the Bragg's law is met, the incident photon beam is reflected from the crystal plane behaving as a specular reflection at the Bragg angle. However, the Bragg reflection physical process has not been integrated into the general-purpose Monte Carlo simulation toolkit Geant4 for particle physics. In the current study, we developed …

Customizable Landmark-Based Field Aperture Design For Automated Whole-Brain Radiotherapy Treatment Planning, Yao Xiao, Carlos Cardenas, Dong Joo Rhee, Tucker Netherton, Lifei Zhang, Raphael Douglas, Stephen Skett, Tina Patel, Chris Trauernicht, Caroline Chung, Hannah Simonds, Ajay Aggarwal, Laurence Court

Faculty, Staff and Student Publications

Purpose: To develop and evaluate an automated whole-brain radiotherapy (WBRT) treatment planning pipeline with a deep learning-based auto-contouring and customizable landmark-based field aperture design.

Methods: The pipeline consisted of the following steps: (1) Auto-contour normal structures on computed tomography scans and digitally reconstructed radiographs using deep learning techniques, (2) locate the landmark structures using the beam's-eye-view, (3) generate field apertures based on eight different landmark rules addressing different clinical purposes and physician preferences. Two parallel approaches for generating field apertures were developed for quality control. The performance of the generated field shapes and dose distributions were compared with the original …

Novel Genetic Regulators Of Fibrinogen Synthesis Identified By An In Vitro Experimental Platform, Dre'von A Dobson, Lori A Holle, Feng-Chang Lin, Jennifer E Huffman, James P Luyendyk, Nicholas L Smith, Alanna C Morrison, Alisa S Wolberg

Faculty, Staff and Student Publications

BACKGROUND: Fibrinogen has an established, essential role in both coagulation and inflammatory pathways, and these processes are deeply intertwined in the development of thrombotic and atherosclerotic diseases. Previous studies aimed to better understand the (patho) physiological actions of fibrinogen by characterizing the genomic contribution to circulating fibrinogen levels.

OBJECTIVES: Establish an in vitro approach to define functional roles between genes within these loci and fibrinogen synthesis.

METHODS: Candidate genes were selected on the basis of their proximity to genetic variants associated with fibrinogen levels and expression in hepatocytes and HepG2 cells. HepG2 cells were transfected with small interfering RNAs targeting …

First-In-Human Phase I Study Of The Ox40 Agonist Gsk3174998 With Or Without Pembrolizumab In Patients With Selected Advanced Solid Tumors (Engage-1), Sophie Postel-Vinay, Vincent K Lam, Willeke Ros, Todd M Bauer, Aaron R Hansen, F Stephen Hodi, Jennifer K Litton, Sandrine Aspeslagh, Karen A Autio, Frans L Opdam, Meredith Mckean, Neeta Somaiah, Stephane Champiat, Mehmet Altan, Anna Spreafico, Osama Rahma, Elaine M Paul, Christoph M Ahlers, Helen Zhou, Herbert Struemper, Shelby A Gorman, Maura Watmuff, Kaitlin M Yablonski, Niranjan Yanamandra, Michael J Chisamore, Emmett V Schmidt, Axel Hoos, Aurelien Marabelle, Jeffrey S Weber, John V Heymach

Faculty, Staff and Student Publications

BACKGROUND: The phase I first-in-human study ENGAGE-1 evaluated the humanized IgG1 OX40 agonistic monoclonal antibody GSK3174998 alone (Part 1 (P1)) or in combination with pembrolizumab (Part 2 (P2)) in patients with advanced solid tumors.

METHODS: GSK3174998 (0.003-10 mg/kg) ± pembrolizumab (200 mg) was administered intravenously every 3 weeks using a continuous reassessment method for dose escalation. Primary objectives were safety and tolerability; secondary objectives included pharmacokinetics, immunogenicity, pharmacodynamics, and clinical activity.

RESULTS: 138 patients were enrolled (45 (P1) and 96 (P2, including 3 crossovers)). Treatment-related adverse events occurred in 51% (P1) and 64% (P2) of patients, fatigue being the most …

Meniscal And Articular Cartilage Predictors Of Outcome After Revision Acl Reconstruction: A 6-Year Follow-Up Cohort Study, Rick W Wright, Laura J Huston, Amanda K Haas, Jacquelyn S Pennings, Christina R Allen, Thomas M Deberardino, Brett Brick A Lantz, Kurt P Spindler, Michael J Stuart, John P Albright, Annunziato Ned Amendola, Jack T Andrish, Christopher C Annunziata, Robert A Arciero, Bernard R Bach, Champ L Baker, Arthur R Bartolozzi, Keith M Baumgarten, Jeffery R Bechler, Jeffrey H Berg, Geoffrey A Bernas, Stephen F Brockmeier, Robert H Brophy, Charles A Bush-Joseph, J Brad Butler, John D Campbell, James L Carey, James E Carpenter, Brian J Cole, Jonathan M Cooper, Charles L Cox, R Alexander Creighton, Diane L Dahm, Tal S David, David C Flanigan, Robert W Frederick, Theodore J Ganley, Elizabeth A Garofoli, Charles J Gatt, Steven R Gecha, James Robert Giffin, Sharon L Hame, Jo A Hannafin, Christopher D Harner, Norman Lindsay Harris, Keith S Hechtman, Elliott B Hershman, Rudolf G Hoellrich, David C Johnson, Timothy S Johnson, Morgan H Jones, Christopher C Kaeding, Ganesh V Kamath, Thomas E Klootwyk, Bruce A Levy, C Benjamin Ma, G Peter Maiers, Robert G Marx, Matthew J Matava, Gregory M Mathien, David R Mcallister, Eric C Mccarty, Robert G Mccormack, Bruce S Miller, Carl W Nissen, Daniel F O'Neill, Brett D Owens, Richard D Parker, Mark L Purnell, Arun J Ramappa, Michael A Rauh, Arthur C Rettig, Jon K Sekiya, Kevin G Shea, Orrin H Sherman, James R Slauterbeck, Matthew V Smith, Jeffrey T Spang, Ltc Steven J Svoboda, Timothy N Taft, Joachim J Tenuta, Edwin M Tingstad, Armando F Vidal, Darius G Viskontas, Richard A White, James S Williams, Michelle L Wolcott, Brian R Wolf, James J York

Faculty, Staff and Student Publications

Background: Meniscal and chondral damage is common in the patient undergoing revision anterior cruciate ligament (ACL) reconstruction.

Purpose: To determine if meniscal and/or articular cartilage pathology at the time of revision ACL surgery significantly influences a patient's outcome at 6-year follow-up.

Study design: Cohort study; Level of evidence, 3.

Methods: Patients undergoing revision ACL reconstruction were prospectively enrolled between 2006 and 2011. Data collection included baseline demographics, surgical technique, pathology, treatment, and scores from 4 validated patient-reported outcome instruments: International Knee Documentation Committee (IKDC), Knee injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and …

Ras Nanoclusters Are Cell Surface Transducers That Convert Extracellular Stimuli To Intracellular Signalling

Faculty, Staff and Student Publications

Mutations of rat sarcoma virus (RAS) oncogenes (HRAS, KRAS and NRAS) can contribute to the development of cancers and genetic disorders (RASopathies). The spatiotemporal organization of RAS is an important property that warrants further investigation. In order to function, wild-type or oncogenic mutants of RAS must be localized to the inner leaflet of the plasma membrane (PM), which is driven by interactions between their C-terminal membrane-anchoring domains and PM lipids. The isoform-specific RAS-lipid interactions promote the formation of nanoclusters on the PM. As main sites for effector recruitment, these nanoclusters are biologically important. Since the spatial distribution of lipids is …

Bacterial Division Ring Stabilizing Zapa Versus Destabilizing Slma Modulate Ftsz Switching Between Biomolecular Condensates And Polymers, Carlos Alfonso

Faculty, Staff and Student Publications

Cytokinesis is a fundamental process for bacterial survival and proliferation, involving the formation of a ring by filaments of the GTPase FtsZ, spatio-temporally regulated through the coordinated action of several factors. The mechanisms of this regulation remain largely unsolved, but the inhibition of FtsZ polymerization by the nucleoid occlusion factor SlmA and filament stabilization by the widely conserved cross-linking protein ZapA are known to play key roles. It was recently described that FtsZ, SlmA and its target DNA sequences (SlmA-binding sequence (SBS)) form phase-separated biomolecular condensates, a type of structure associated with cellular compartmentalization and resistance to stress. Using biochemical …

Aapm Medical Physics Practice Guideline 13a: Hdr Brachytherapy, Part A, Susan L Richardson, Ivan M Buzurovic, Gil'ad N Cohen, Wesley S Culberson, Claire Dempsey, Christopher S Melhus, Daniel J Scanderbeg, Samantha J Simiele

Faculty, Staff and Student Publications

The American Association of Physicists in Medicine (AAPM) is a nonprofit professional society whose primary purposes are to advance the science, education, and professional practice of medical physics. The AAPM has more than 8000 members and is the principal organization of medical physicists in the United States. The AAPM will periodically define new practice guidelines for medical physics practice to help advance the science of medical physics and to improve the quality of service to patients throughout the United States. Existing medical physics practice guidelines (MPPGs) will be reviewed for the purpose of revision or renewal, as appropriate, on their …

Naltrexone-Bupropion Combinations Do Not Affect Cocaine Self-Administration In Humans, Sean D Regnier, William W Stoops, Joshua A Lile, Joseph L Alcorn, B Levi Bolin, Lon R Hays, Craig R Rush

Faculty, Staff and Student Publications

The FDA has not yet approved a pharmacotherapy for cocaine use disorder despite nearly four decades of research. This study determined the initial efficacy, safety, and tolerability of naltrexone-bupropion combinations as a putative pharmacotherapy for cocaine use disorder. Thirty-one (31) non-treatment seeking participants with cocaine use disorder completed a mixed-design human laboratory study. Participants were randomly assigned to the naltrexone conditions (i.e., 0, 50 mg/day; between-subject factor) and maintained on escalating doses of bupropion (i.e., 0, 100, 200, 400 mg/day; within-subject factor) for at least four days prior to the conduct of experimental sessions. Cocaine self-administration (IN, 0, 40, 80 …

Measuring Dna Modifications With The Comet Assay: A Compendium Of Protocols, Awadhesh N. Jha

School of Biological and Marine Sciences

The comet assay is a versatile method to detect nuclear DNA damage in individual eukaryotic cells, from yeast to human. The types of damage detected encompass DNA strand breaks and alkali-labile sites (e.g., apurinic/apyrimidinic sites), alkylated and oxidized nucleobases, DNA–DNA crosslinks, UV-induced cyclobutane pyrimidine dimers and some chemically induced DNA adducts. Depending on the specimen type, there are important modifications to the comet assay protocol to avoid the formation of additional DNA damage during the processing of samples and to ensure sufficient sensitivity to detect differences in damage levels between sample groups. Various applications of the comet assay have been …

Effect Of Sirolimus On Insulin Dynamics In Horses, Kate L Kemp

Faculty, Staff and Student Publications

BACKGROUND: Sirolimus, a mechanistic target of rapamycin inhibitor, suppresses insulin production in other species and has therapeutic potential for hyperinsulinemia in horses.

HYPOTHESIS/OBJECTIVE: Determine the pharmacokinetics (PKs) of sirolimus and evaluate its effect on insulin dynamics in healthy and insulin dysregulation (ID) horses.

ANIMALS: Eight Standardbred geldings.

METHODS: A PK study was performed followed by a placebo-controlled, randomized, crossover study. Blood sirolimus concentrations were measured by liquid chromatography-mass-spectrometry. PK indices were estimated by fitting a 2-compartment model using nonlinear least squares regression. An oral glucose test (OGT) was conducted before and 4, 24, 72, and 144 hours after administration of …

Singlet Oxygen Quenching By Resveratrol Derivatives, Jin Hyeok Yoon

Faculty, Staff and Student Publications

We investigated the singlet oxygen quenching ability of several derivatives of trans-resveratrol which have been reported to have significant antioxidant ability, including photoprotective activity. We measured the total rate constants of singlet oxygen removal (kT) by the methylated resveratrol derivative 1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene, and the partially methylated resveratrol derivatives 4-((E)-2-(3,5-dimethoxyphenyl)ethenyl)phenol (pterostilbene), 5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene-1,3-diol and (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one (dihydromyricetin). A protic solvent system results in higher kT values, except for the completely methylated derivative. We also investigated the ability of trans-resveratrol to directly act as a photosensitizer (rather than via secondary photoproducts resulting from other primary photochemical …

Gender-Associated Cardiometabolic Risk Profiles And Health Behaviors In Patients With Type 2 Diabetes: A Cross-Sectional Analysis Of The Joint Asia Diabetes Evaluation (Jade) Program, Vanessa Lau, K H Yoon, Alexander T B Tan, Yook-Chin Chia, Aravind Sosale, Banshi D Saboo, Jothydev Kesavadev, Su-Yen Goh, Thy Khue Nguyen, Yotsapon Thewjitcharoen, Raymond Suwita, Ronald C W Ma, Elaine Y K Chow, Andrea O Y Luk, Juliana C N Chan

Faculty, Staff and Student Publications

Background

In Asia, diabetes-associated death due to cardiorenal diseases were 2–3 times higher in women than men which might be due to gender disparity in quality of care and health habits.

Methods

Adults with type 2 diabetes (T2D) from 11 Asian countries/areas were assessed using the same protocol (2007–2015). We compared treatment target attainment (HbA_1c < 7%, blood pressure [BP] < 130/80 mmHg, risk-based LDL-cholesterol, lack of central obesity [waist circumference <90 cm in men or <80 cm in women), use of cardiorenal-protective drugs (renin-angiotensin system [RAS] inhibitors, statins), and self-reported health habits including self-monitoring blood glucose (SMBG) by gender. Analyses were stratified by countries/areas, age of natural menopause (<50 vs. ≥50 years), and comorbidities (atherosclerotic cardiovascular disease [ASCVD], heart failure, kidney impairment [eGFR < 60 mL/min/1.73 m²]).

Findings

Among 106,376 patients (53.2% men; median (interquartile range) diabetes duration: 6.0 (2.0–12.0) years; mean ± SD HbA_1c 8.0 ± 1.9%; 27% insulin-treated), women were older and …

Building The Foundation For A Community-Generated National Research Blueprint For Inherited Bleeding Disorders: Research Priorities To Transform The Care Of People With Hemophilia, Amy L Dunn, James Jorgenson, Scott D Martin, Suzanne Martin, Shannon L Meeks, Alfredo A Narvaez, Doris V Quon, Mark T Reding, Ulrike M Reiss, Brittany Savage, Kim Schafer, Bruno Steiner, Courtney Thornburg, Lena M Volland, Annette Von Drygalski

Faculty, Staff and Student Publications

BACKGROUND: Decades of research have transformed hemophilia from severely limiting children's lives to a manageable disorder compatible with a full, active life, for many in high-income countries. The direction of future research will determine whether exciting developments truly advance health equity for all people with hemophilia (PWH). National Hemophilia Foundation (NHF) and American Thrombosis and Hemostasis Network conducted extensive inclusive all-stakeholder consultations to identify the priorities of people with inherited bleeding disorders and those who care for them.

RESEARCH DESIGN AND METHODS: Working group (WG) 1 of the NHF State of the Science Research Summit distilled the community-identified priorities for …

Release Of Tephra-Hosted Iron During Early Diagenesis Fingerprinted By Iron Isotopes, Jack Longman, Ann G. Dunlea, Philipp Böning, Martin R. Palmer, Thomas M. Gernon, James Mcmanus, Hayley R. Manners, William B. Homoky, Katharina Pahnke

School of Geography, Earth and Environmental Sciences

The micronutrient iron (Fe) plays a fundamental role controlling primary productivity in the upper ocean, with volcanic eruptions and deposition of airborne volcanic material (termed tephra) a potential source of Fe. Here, we investigate the geochemical and Fe isotopic ( Fe) composition of tephra layers, sediments, and mixed tephra-sediment samples from the Integrated Ocean Drilling Program (IODP) Hole 1396C, located offshore the volcanically active island of Montserrat in the Lesser Antilles, Caribbean Sea. We find that buried tephras, which have experienced diagenesis, exhibit lighter Fe (relative to standard IRMM-524a) compositions (down to −0.26 ± 0.04‰, 2SD) than fresh tephra deposited …

Children Over-Imitate Adults And Peers More Than Puppets., Roman Stengelin, Rabea Ball, Luke Maurits, Patricia Kanngiesser, Daniel B.M. Haun

School of Psychology

Researchers commonly use puppets in development science. Amongst other things, puppets are employed to reduce social hierarchies between child participants and adult experimenters akin to peer interactions. However, it remains controversial whether children treat puppets like real-world social partners in these settings. This study investigated children's imitation of causally irrelevant actions (i.e., over-imitation) performed by puppet, adult, or child models. Seventy-two German children (Age_Range = 4.6-6.5 years; 36 girls) from urban, socioeconomically diverse backgrounds observed a model retrieving stickers from reward containers. The model performed causally irrelevant actions either in contact with the reward container or not. Children were …

Relationships Between Farmer Psychological Profiles And Farm Business Performance Amongst Smallholder Beef And Poultry Farmers In South Africa, Renato A. Villano, Isaac Koomson, Nkhanedzeni B. Nengovhela, Livhuwani Mudau, Heather M. Burrow, Navjot Bhullar

Research outputs 2022 to 2026

Beef cattle and poultry are critically important livestock for improving household food security and alleviating poverty amongst smallholder farmers in South Africa. In this paper, our goal is to examine the relationships between farmer psychological profiles and farm business performance of commercially oriented beef cattle and poultry smallholder farmers in South Africa. We employ a multipronged interdisciplinary approach to test the theory of planned behaviour and its relationship to farm business performance. First, a behavioural science-informed survey instrument was employed to collect data from randomly selected farmer participants in two major beef and poultry projects undertaken by the authors. Second, …

Mathematical Models For Thalassemia, Hamda Mohammed Al Dhaheri

Theses

Thalassemia is a genetic blood disorder caused by gene mutation or deletion in a blood protein called hemoglobin. Treatment of thalassemia requires a life-long blood transfusion and removal of excessive iron in the blood stream, which usually causes a big pressure on health care systems. Various forms of thalassemia control measures have been used to reduce the prevalence of thalassemia major. This has resulted in a substantial reduction in the prevalence of thalassemia. However, the thalassemia carrier population remains high, which could lead to an increase in the thalassemia major population through carrier-to-carrier marriages. Thus, we developed two mathematical models …

Design And Assessment Of A Leo Gnss Miniconstellation For Positioning, Navigation, And Timing (Pnt), Mariya Abdulkhaleq Mohamad

Theses

Recently, there has been a resurgent demand in the United Arab Emirates for more accurate positioning, navigation, and timing signals, especially for some targeted applications such as autonomous vehicles and flying taxis. The existing Global Navigation Satellite Systems (GNSS) provide real-time positioning accuracy for up to several meters, while the targeted applications require fast convergence of centimeterlevel positioning accuracy. Recent studies have shown that transmitting GNSS signals from a Low Earth Orbit (LEO) instead of a Medium Earth Orbit (MEO) would enhance positioning accuracy. The main objective of this thesis is to design and simulate an optimum scenario of a …

Molecular Characterization Of Germination Of Date Palm Seeds Maintained At Microgravity In Outer Pace (International Space Station), Wesam Izzeldeen Khader

Theses

Over the past decade, the UAE has experienced unprecedented innovations in the space sector. Collaborating closely with universities and space agencies around the world, the country's efforts have advanced steadily but quietly under the public radar. The proposed research focuses on basic research to complement the UAE initiative to send date palms to Mars for future space missions. Plant growth analysis of date palm seeds was performed after maintaining at zero gravity in outer space in the International Space Station (ISS) and simultaneously under normal gravity at ground level. In this context, this work was carried out to analyze the …

Feasibility Study On The Characterization Of Mars Atmospheric And Surface Features In Spacecraft Images By Machine Learning And Similar Automated Methods, Hind Hassan Alriyami

Theses

This thesis is focused on automated detection of Mars atmospheric and surface features in spacecraft images based on machine learning and similar automated methods using crater detection algorithm (CDA) software, named DeepMars2 algorithm. The purpose of this study is to perform machine learning to detect coarse and high-resolution topography craters on mars. The algorithm is applied to two digital elevation models (DEMs) of the Mars surface with high and coarse resolution in order to identify craters using machine and deep learning methods. The DEMs are based on the satellite instruments MOLA/MGS (Mars Orbiter Laser Altimeter/Mars Global Surveyor) and HRSC/MEX (High …

The Cost Of Connectivity - Assessing The Impact Of Superblock Road Design Costs On The Distance, Directness, And Diversity Of Pedestrian Routes, Rim Ibrahim Anabtawi

Theses

Superblocks have been massively constructed and cover a remarkable amount of Abu Dhabi’s urban landscape. Recent research has shown that Abu Dhabi’s superblocks promote car dependency, which dominates approximately all local transportation, and results in increases in fossil fuel consumption, increase in greenhouse gas emissions, and negative impacts on air quality. This thesis, along with multiple recent studies, addressed this issue, looking at the different designs of internal road networks of residential superblocks in order to better understand their connectivity. The evaluation of different network designs used in the city’s superblocks has provided valuable insights by which to support and …

The Three-Dimensional Visualization Of Mars Dust Storms Based On Deriving Digital Elevation Maps From Satellite Imagery, Meirah Ali Alzeyoudi

Theses

This work focuses on generating a Three-Dimensional Visualization of Mars's local dust storms utilizing satellite images from publicly available archives. The work aimed to create a Three-Dimensional Visualization of two Local Dust storms, the first local dust storm occurred on May 20, 2020, in the Chryse Planitia Region of Mars, while the second one occurred on 8 June 2021, on the northern side of the Utopia Planitia Region of Mars. The visualization will assist in providing a better understanding of the dynamics of Dust Storms on Mars by indicating and analyzing the main features of dust storms on Mars. Also, …

Correlation Between The Preparation Methods And The Physiochemical Characteristics Of Mgal₂O₄ As A Support For Ni Catalysts In Partial Oxidation Of Methane, Fatima El Alem

Theses

Due to different technical challenges associated with direct use of methane, the main component of natural gas, its conversion to higher hydrocarbons has been a subject of great industrial importance. All of the known routes for methane conversion are catalytic processes, where the performance is largely dependent on the physicochemical properties of the catalyst. The catalysts that have shown promising performance in methane reforming are based on expensive metals such as Pt, Pd, and Ru. Ni, on the other hand, is a cost-effective metal and has shown promising catalytic activity. These catalysts are usually in the form of metal nanoparticles …

Generating Synthetic Satellite Images Of Mars Dust Storms Based On Radiative Transfer Models, As A Follow-On Application Of Marswrf Dust Cycle Simulations, Fatima Ali Alkaabi

Theses

Dust is a fundamental component of the Martian atmosphere; it plays a vital role in the planet's climate system and atmospheric variability. For these reasons, it is considered one of the essential keys to understanding the Martian atmosphere's behavior. The dust events on Mars range from local/regional dust storms that occur every Martian year to global dust storms that have only been observed, on average, once every 3-4 Martian years. The large regional and global dust storms have strong thermal and dynamic effects on the atmosphere. MarsWRF is a Mars version of the terrestrial numerical weather and climate model WRF …

Specification-Based Autonomous Driving System Testing, Yuan Zhou, Yang Sun, Yun Tang, Yuqi Chen, Jun Sun, Christopher M. Poskitt, Yang Liu, Zijiang Yang

Research Collection School Of Computing and Information Systems

Autonomous vehicle (AV) systems must be comprehensively tested and evaluated before they can be deployed. High-fidelity simulators such as CARLA or LGSVL allow this to be done safely in very realistic and highly customizable environments. Existing testing approaches, however, fail to test simulated AVs systematically, as they focus on specific scenarios and oracles (e.g., lane following scenario with the "no collision" requirement) and lack any coverage criteria measures. In this paper, we propose AVUnit, a framework for systematically testing AV systems against customizable correctness specifications. Designed modularly to support different simulators, AVUnit consists of two new languages for specifying dynamic …

Concept-Oriented Transformers For Visual Sentiment Analysis, Quoc Tuan Truong, Hady Wirawan Lauw

Research Collection School Of Computing and Information Systems

In the richly multimedia Web, detecting sentiment signals expressed in images would support multiple applications, e.g., measuring customer satisfaction from online reviews, analyzing trends and opinions from social media. Given an image, visual sentiment analysis aims at recognizing positive or negative sentiment, and occasionally neutral sentiment as well. A nascent yet promising direction is Transformer-based models applied to image data, whereby Vision Transformer (ViT) establishes remarkable performance on largescale vision benchmarks. In addition to investigating the fitness of ViT for visual sentiment analysis, we further incorporate concept orientation into the self-attention mechanism, which is the core component of Transformer. The …

Generalizing Graph Neural Network Across Graphs And Time, Zhihao Wen

Research Collection School Of Computing and Information Systems

Graph-structured data widely exist in diverse real-world scenarios, analysis of these graphs can uncover valuable insights about their respective application domains. However, most previous works focused on learning node representation from a single fixed graph, while many real-world scenarios require representations to be quickly generated for unseen nodes, new edges, or entirely new graphs. This inductive ability is essential for high-throughtput machine learning systems. However, this inductive graph representation problem is quite difficult, compared to the transductive setting, for that generalizing to unseen nodes requires new subgraphs containing the new nodes to be aligned to the neural network trained already. …

Proactive Conversational Agents, Lizi Liao, Grace Hui Yang, Chirag Shah

Research Collection School Of Computing and Information Systems

Conversational agents, or commonly known as dialogue systems, have gained escalating popularity in recent years. Their widespread applications support conversational interactions with users and accomplishing various tasks as personal assistants. However, one key weakness in existing conversational agents is that they only learn to passively answer user queries via training on pre-collected and manually-labeled data. Such passiveness makes the interaction modeling and system-building process relatively easier, but it largely hinders the possibility of being human-like hence lowering the user engagement level. In this tutorial, we introduce and discuss methods to equip conversational agents with the ability to interact with end …