Digital Commons Network^™

Stability Of Sufentanil Sublingual Microtablets (Dzuveo) In Extreme Cold Weather Conditions: An Experimental Study, David Mcconnell, Hayley Manners, Paul Sutton, Nicola Gawman, Tim Parham, Jonathon Lowe

School of Geography, Earth and Environmental Sciences

Introduction Extreme cold weather environments are challenging for medication storage and delivery, particularly for injectable analgesics vulnerable to freezing and device failure. These risks may compromise pain management in austere or operational settings where temperature control cannot be maintained. Sufentanil sublingual microtablets (sold in the UK as Dzuveo) provide an oral analgesic option with manufacturer-reported sub-zero stability. Evidence describing the effects of sustained extreme cold exposure and repeated freeze–thaw cycling on chemical stability and delivery system function is limited.Methods We conducted a laboratory study assessing the effect of sustained freezing and repeated freeze–thaw exposure on sufentanil sublingual microtablets (30 µg …

What History Shows: A Structural Account Of Fixed-Point Theory Formation, Griselda Poe

Publications and Research

Theory generation has long been subsumed under categories such as creativity, genius, and innovation. These categories do not distinguish assembly-based conceptual synthesis from fixed-point theory generation.

This paper makes that distinction explicit. The termination condition of assembly is external: data, citation, endorsement, usability. The termination condition of fixed-point theory generation is internal: consistency with internally held constraints, resolution of structural contradiction. The two operate under different processing conditions.

The historical record confirms this distinction. What Darwin, Einstein, Spinoza, and Kant produced was not assembly. Their processes involved unresolved branch retention and decomposition necessity, arriving at internally constrained fixed-point termination. Freud …

Asymmetric Synthesis Of Borylated Amines Via Rhodium Catalyzed Hydroboration Of Allylamine Derivatives: Surprising Role Of Counterions And Accelerators, Rukshani Wickrama Arachchilage

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The Catalytic Asymmetric Hydroboration (CAHB) reaction is a valuable method for synthesizing chiral organoboron compounds. Nevertheless, key mechanistic details, including catalyst activation, ligand effects, and rate-determining steps, are difficult to generalize and remain not fully understood. Building on previous research from the Takacs group, this work explores acyclic N-acyl allylamines as substrates in rhodium-catalyzed hydroboration and investigates the formation of active catalysts from various rhodium precursors, the role of counterions (e.g. BF₄, BArF-), ligand-to-metal ratios, and the impact of external fluoride additives (e.g. TBAT). Hydroboration of acyclic N-acyl allylamines achieves up to 90% yield and 99 : 1 …

Interventions For Behavioral Symptoms Of Dementia, Christina Khouri, Robert Martin

Advocate GME

No abstract provided.

Empowering Junior High School Students’ Collaboration Skills Through Science Learning Using The Secret Mission Game, Rahma Fika Kurnia, Imraatul Mufidah, Dyne Rizki Puspitasari

Journal of Innovation and Teacher Professionalism

This study aimed to empower the collaboration skills of Class VII B students at SMP Laboratorium UM through the implementation of the Game-Based Learning model using the Secret Mission game in science learning on the topic of Physical and Chemical Changes. The study was motivated by the low level of students’ collaboration skills, as indicated by previous classroom assignments that were mostly completed individually rather than collaboratively in groups. The study employed the Lesson Study approach, which consisted of three stages: Plan, Do, and See. During the planning stage, the Lesson Study team collaboratively designed learning modules, game scenarios, instructional …

Propasafe-Hybrid: A Text-Based Hybrid Propaganda Detection Tool, Thomas Kimmeth, Avijit Roy, Vivek Sharma

Publications and Research

Propagandistic content increasingly circulates through online news and social media, where readers often encounter it with limited scrutiny, highlighting the need for reliable and fine-grained detection. This paper introduces Propasafe-Hybrid, a sentence-level system that integrates a fine-tuned transformer classifier with LLM-based technique classification to identify, label, and explain specific propaganda strategies. The pipeline generates actionable outputs, including highlighted sentences, technique assignments, and concise rationales, so users can immediately understand why a sentence was flagged and how each label was determined. To control inference cost, Propasafe-Hybrid employs a cost-aware pre-filtering stage that forwards only high-likelihood sentences to LLMs, reducing token usage …

Predicting And Decoding Allosteric Binding Sites Using Protein Language Models And Structure-Based Machine Learning: An Energy Landscape-Guided Explainable Ai Framework, Kamila Riedlová, Vít Skrhák, William G. Gatlin, Max Ludwick, Lucas Turano, Marian Novotný, David Hoksza, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Computational prediction of allosteric binding sites in protein structures remains a persistent challenge, as these regulatory pockets evade detection by both sequence-based and structure-based algorithms. Both computational and physical origins of this predictive asymmetry remain insufficiently understood. In this study, we systematically examine the determinants of binding site predictability using a dual framework that integrates a fine-tuned protein language model and the structure-based method P2Rank as complementary tools probing a diverse data set of 453 human kinases, together with a physics-based interpretability layer derived from energy landscape frustration analysis. Both predictors exhibit a sharp and reproducible dichotomy on protein kinases, …

Does Your Sleep Really Matter?, Kristy Riddle

Student Scholar Symposium Abstracts and Posters

In this project, I am tracking 10 of my daily statistics revolving around my routine. I am using an Oura Ring to help accomplish some of the statistics. These include: readiness score, sleep score, screen time on cell phone, time spent on social media, steps taken, stress levels, restorative time, pages read, homework time spent, and oz of water consumed. I will be utilizing Excel for my data and will have around 3 months worth of statistics. hope to learn more about my levels of efficient sleep and how I can better improve my motivation as a student. This project …

Assessment Of Cognitive Function In Stroke Survivors Using The Montreal Cognitive Assessment (Moca), Georgia Cameron

Student Scholar Symposium Abstracts and Posters

Falls are a common and serious complication in post-stroke patients, with 37–73% of individuals falling within the first 6 months post-stroke and up to 73% within the first year (Verheyden et al., 2013). This study is part of a broader investigation examining whether gait characteristics and impaired cognitive function can predict fall risk when used alongside artificial intelligence. Prior to strength testing and gait analysis, multiple surveys were administered to assess the participants' cognitive function, including the Montreal Cognitive Assessment (MoCA). The MoCA is a cognitive screening tool developed to detect mild cognitive impairment and assess multiple cognitive domains, including …

Computational Ligand-Receptor Simulations Of Fluorinated Morphine Derivatives Using Pymol, Mirabella Romano, Emily Chen

Student Scholar Symposium Abstracts and Posters

The opioid epidemic impacts 60 million people worldwide every year. Morphine, a commonly prescribed opioid, binds to the μ-opioid receptor (MOR) in the body via protonation of its tertiary amino group and the MOR. An unfortunate side effect of this binding process is its non-selectivity in both peripheral and central tissues. While activation within inflamed peripheral tissues results in pain relief, activation within central tissues results in the unwanted and addictive side effects of opioids. Because there is a pH discrepancy between healthy (central) and inflamed (peripheral) tissues, selective binding in the inflamed tissues could provide pain relief without addictive …

Developing Narrative-Based Stem Learning Tool For K-6 Visually Impaired Students, Daniel Tsivkovski, Dylan Ravel, Jeffrey Kraskouskas, Brandon Foley, Maryam Etezad, Franceli Cibrian, Rajeev Joshi, Ariel Han

Student Scholar Symposium Abstracts and Posters

This research develops a free, accessible web application that enables K-6 students who are blind or visually impaired (BVI) to learn STEM concepts using refreshable braille displays. Currently, most online learning tools are not designed for BVI students, creating a significant educational barrier.

The application interfaces with commercial braille displays and uses narrative-based learning to make STEM content approachable and engaging. By presenting material as personalized interactive stories generated with the help of Artificial Intellligence (AI), students can connect with concepts while developing braille reading skills. The curriculum design prioritizes accessibility through the Accessible Rich Internet Applications (ARIA) standards and …

Listening To The Landscape: Designing A Conversational Agent For Native Botanical Literacy, Lucy Periale

Student Scholar Symposium Abstracts and Posters

This project investigates how physical devices integrated with conversational AI can support botanical literacy and encourage engagement with the natural world, with a particular focus on increasing awareness of California native plants. It asks: how can tangible, voice-interactive devices facilitate place-based learning without disrupting direct outdoor experience? Existing plant identification tools rely on screen-based interaction, which can distance users from their natural surroundings. This research contributes to interaction design and human-computer interaction discourse by exploring embodied learning through devices that prioritize environmental immersion. This project developed multiple design concepts and developed three prototypes namely Buddy Bot, Radio Agent and Plant …

Interpreting American Sign Language: A Literature Review Of Assistive Technologies, Natalie Louise Paradiso, Emma Grace Kochenderfer

Student Scholar Symposium Abstracts and Posters

American Sign Language (ASL) is a visually elaborate, spatially oriented linguistic methodology that relies on combinations of hand movements, body positioning, facial expressions, and motion/spatial perception, aspects of which make interpretation difficult for automated machine recognition. Current assistive technology approaches to ASL interpretation are generally within the categories of computer vision models (including deep learning, multi-focus image fusion, and keypoint tracking) and wearable, multimodal/sensor-based approaches (such as smart glasses and inertial-sensor gloves). Within controlled environments, computer vision models perform well. However, when applied to conditions such as non-manual signs/features, signer variability, and rapid assimilation, they falter in processing all aspects …

Between Authenticity And Exploitation: Rethinking The Intended Audience Of Sean Baker's Tangerine, Ava Brandt

Student Scholar Symposium Abstracts and Posters

Sean Baker's Tangerine (2015) has generated genuinely divided responses among trans critics, and for good reason. This paper takes that division seriously, using two reviews published on Autostraddle within six weeks of each other to frame a central question: who is Tangerine actually for? Existing scholarship on trans cinema has tended to evaluate films on a spectrum from exploitative to affirming, but this paper argues that framework is insufficient for a film like Tangerine, which operates as both simultaneously. Through close reading of the film alongside its production history, paratexts, and reception, and drawing on Paige Macintosh's scholarship on trans …

Freshman 15? Freshman 50?? The Reality Of Daily Life Habits Of A First Year College Student, Gregorio R. Salgado

Student Scholar Symposium Abstracts and Posters

This project presents a personal data tracking study in which I collected daily self-reported metrics over the course of the Spring semester using Excel. The variables tracked include sleep duration, caloric intake, screen time, social media usage, phone checks per day, family communication, and personal spending. The goal of this project is to identify meaningful patterns and correlations between daily habits and personal well-being.

Data was collected through a combination of manual logging and smartphone-generated daily reports. This study explores potential relationships between variables such as sleep duration and social media usage, as well as the association between family communication …

L'Empire De L'Élégance: Histoire Et Marketing Du Luxe En France (The Empire Of Elegance: The History And Marketing Of Luxury In France), Kayleigh Gilbert

Student Scholar Symposium Abstracts and Posters

This thesis explores how France established and maintains its global leadership in the luxury sector by transforming high-end consumption from a tool of royal power into a modern economic pillar. The central research examines the historical evolution of French luxury, moving from the court of Louis XIV at Versailles to current global marketing, as well as how the strategic use of France’s national identity creates a manufactured desire that goes beyond a physical product. Within the context of luxury history and consumer economics, the project builds upon the work of scholars like William Beik and Michael Kwass to show how …

Kl Dra As A Benchmark Laboratory For Accretion-Disk Physics: Constraints From Tess And Ground-Based Surveys, Luis E. Salazar Manzano, Liliana E. Rivera Sandoval, Jean-Marie Hameury, Craig O. Heinke, Iwona Kotko, Thomas J. Maccarone, Manuel Pichardo Marcano

Physics & Astronomy Faculty Publications

We present the longest-term optical analysis of the AM CVn system KL Dra using ∼11 yr of monitoring from TESS and wide-field ground-based surveys. The continuous TESS coverage allows us to characterise its frequent outbursts with unprecedented detail, providing the first comprehensive study of an AM CVn during outbursts and enabling detailed modelling of these systems. The superoutbursts in KL Dra generally include a precursor and are followed by a series of rebrightenings after which a sequence of 3–4 large amplitude normal outbursts is observed. We fit parametric profiles to each superoutburst component (precursor, rise to plateau, plateau, and decay), …

Coal Ash-Derived Aluminosilicate Precursors: A Chemical Engineering Approach To Geopolymer Characterization, Hafiz Abdul Basit, Abdullah Bashir, Abdur Raafey

World of Coal Ash Proceedings

The chemical and microstructural evaluation of coal-derived aluminosilicate precursors is critical for understanding their suitability in advanced construction material systems. In this study, a characterization of Class F fly ash, ground granulated blast furnace slag (GGBFS), and Silica Fumes (SF) was conducted to elucidate their morphological and elemental features. Scanning Electron Microscopy (SEM) was used to assess particle morphology and surface characteristics (porosity, particle diameter, particle geometry), and Energy-Dispersive X-ray Spectroscopy (EDS) to determine elemental composition and distribution. The analysis revealed distinct morphological and compositional differences among the precursors, including spherical fly ash particles, calcium-rich slag phases, and ultra-fine silica …

State Permitting Program Update, Jessica Reiss

World of Coal Ash Proceedings

State Permitting Program Update Jessica L. Reiss, Barnes & Thornburg LLP, 11 South Meridian Street, Indianapolis, IN 46204 KEYWORDS: states, permitting, permit program, rulemaking ABSTRACT At the end of 2016, the United States Congress authorized states to establish permit programs for coal combustion residuals (CCR) surface impoundments and landfills.[1] Since then, several states have established such programs, and the United States Environmental Protection Agency (U.S. EPA) has approved programs for Oklahoma,[2] Georgia,[3] Texas,[4] and North Dakota,[5] proposed approval for Wyoming,[6] and denied approval for Alabama.[7] Other states, such as Indiana,[8] are actively working through the state rulemaking process and plan …

Zero-Waste And High-Value Valorization Of Coal Combustion Residues Via Critical Minerals Recovery And Cementitious Materials Production, Hongyan Ma

World of Coal Ash Proceedings

Coal combustion residues (CCRs) pose significant environmental and disposal challenges, yet they also represent an untapped resource rich in aluminosilicates and critical minerals. This work presents a zero-waste, high-value valorization pathway that integrates critical mineral recovery with the production of cementitious materials. Advanced separation and extraction techniques are employed to recover strategically important elements such as gallium and rare earths, while the mineral-rich residues are simultaneously processed into supplementary cementitious materials (SCMs) for blended cements and concretes. This integrated approach not only offsets the environmental burden of CCR disposal but also supports domestic supply chains of critical minerals and reduces …

Revolutionizing Closure Systems: The Performance Advantages Of Structured Geomembranes, Scott Perugia

World of Coal Ash Proceedings

Coal combustion residual (CCR) containment facilities have traditionally been closed using methods that have changed little over several decades, but structured geomembranes are now reshaping closure design by improving slope stability, increasing interface friction, enhancing drainage, and providing long-term durability. Two systems are emerging as leading solutions: a structured geomembrane paired with a geotextile and vegetative cover, and a structured geomembrane paired with engineered turf. This presentation compares these approaches using field performance data, laboratory testing, and lessons learned, with emphasis on key factors such as infiltration control, drainage efficiency, slope stability, constructability, and regulatory compliance. The engineered turf system …

Developing Concentrated Brines / Salt Slurries For Disposal Of Coal Ash Wastewaters., Lance Edling

World of Coal Ash Proceedings

If coal ash wastewater is not fully concentrated to the greatest extent possible, then this results in greater disposal volumes and costs. However, concentrating a wastewater stream high in scaling compounds can be difficult. Membranes are prone to scale and Vacom thermal systems are higher in operating cost. This presentation will discuss the need to minimize disposal volumes by concentrating wastewater that is readily prone to scale and foul. The discussion will present past project examples of waste streams that were concentrated until salt crystals formed and the method used to minimize fouling and scaling during the concentration process. In …

Recinis™ Wet Beneficiation Process For Landfilled Coal Ash, Tim Sambrook

World of Coal Ash Proceedings

The decline of coal-fired power generation has reduced fresh “Run-of-Station” ash availability, increasing reliance on reclaimed ash from landfills to meet supplementary cementitious material (SCM) demand. This shift has lowered OPC replacement rates and raised concrete costs due to inconsistent ash quality. ReCinis™ offers a low-capex wet beneficiation solution for landfill-aged, saturated, and variable-quality coal ash. With over 5 billion tons of ash impounded in the U.S., this process enables long-term supply security where dry beneficiation is unsuitable. Combining proven mineral processing techniques with coal ash expertise, ReCinis™ can be deployed as a 150,000 tpa skid-mounted plant or scaled to …

Lessons Learned From A Full-Scale Discrete In-Situ Stabilization Project For Ccr Impoundment Closure, Tony Moran, Paul Jennings, Jacob Susser, Tim Silar

World of Coal Ash Proceedings

ENTACT, in collaboration with Silar Services, Inc., the patent holder of Discrete In-Situ Solidification (DISS) technology, has successfully performed a full-scale implementation of DISS in a Coal Combustion Residual (CCR) impoundment. DISS hydraulically isolates ash from surrounding groundwater by constructing a low-permeability barrier at the impoundment bottom to treat a layer of ash and tying into underlying natural soil layers. DISS enables targeted stabilization within a designated treatment zone, minimizing the disturbance of overburden compared to traditional excavation methods and reducing the use of costly cementitious reagents. The process starts with Reagentless Drilling of the overburden CCR utilizing a specialized …

From Clogs To Compliance: Overcoming Persistent Leachate Head Issues In Ccr Landfills, Breanne Kahnk, Zachary Bauman

World of Coal Ash Proceedings

State and federal regulations require that landfills, including coal combustion residual (CCR) landfills, be designed and operated to maintain leachate head levels of less than 30 centimeters (approximately 1 foot). While proper leachate collection system design and routine maintenance are critical for meeting this requirement, challenges such as clogging of drainage media, pipes, fittings and/or pipeline perforations, settlement of collection pipes, and breaks in the piping system can lead to elevated leachate levels, posing risks to compliance and long-term system performance. TRC will provide an overview of leachate collection system regulatory requirements along with design, operation, and maintenance strategies that …

Plasma Coal Ash Processing For Enhanced Recovery Of Rare Earth Elements & Precious Metals: Proven From R&D To Commercial Plants, George Paskalov, Victoria Campbell, Jason Honigberg

World of Coal Ash Proceedings

Our Radio-frequency Plasma System is an ash pretreatment before the application of extractive metallurgy and addresses current elemental, methodological, and technological limitations of complex and refractory coal ash. Our system data shows from 10-20% improved recovery, to 9x-100x. RFP can access all metals contained in coal ash. Our focus is not on the alteration of established methodologies, such as cyanidation for non-refractory ore, which has a proven return and capacity to achieve target revenue at-scale. Using the RFP systems, no waste is created, overburden can be more easily dealt with, and no metal content will be left behind. We assert …

Probing The Critical Element Chemistry Of Coal-Combustion Fly Ash: Electron Microbeam Investigations Of The Spent Ash From The Pilot-Scale Acid Extraction Of Rare Earth Elements From A Beneficiated Kentucky Fly Ash, James Hower

World of Coal Ash Proceedings

Fly ash derived from the combustion of an eastern Kentucky high volatile bituminous coal blend was beneficiated to yield a <75-μm product with a reduction in the carbon and spinels and reacted with a strong acid in a pilot-scale unit to extract rare earth elements. Electron microscopy showed a wide range of rare earth-bearing minerals. The acid-extracted fly ash had a rim that was depleted in REE and in most other elements except silicon.

Standardization Of Coal Ash Testing, Classification, And Harvesting, Benjamin Gallagher, Chris Frishcosy, Eric Hageman

World of Coal Ash Proceedings

Standards such as product specifications, test methods, practices and guides play a crucial role in supporting both commerce and science. Standardization helps build consistency and reliability whether it pertains to the performance of an ingredient in a product or in the measurement of a material characteristic. Coal combustion products, such as coal ash and synthetic gypsum, exhibit unique characteristics and many standard have been developed to characterize these materials and support their beneficial use. ASTM is a voluntary, consensus-based organization, and publishes many standards related to coal combustion products. Currently, there are seven ASTM standards related to chemical analysis of …

Leachate Quantification And Reduction – One Facility’S Path To Zld, Cedric Ruhl

World of Coal Ash Proceedings

The Environmental Protection Agency (EPA) promulgated Effluent Limitation Guidelines (ELG) that govern liquids discharged from energy production facilities. According to the ELG, energy production facilities that burn coal beyond December 31, 2034 must convert to a Zero Liquid Discharge (ZLD) system by December 31, 2029*. This presentation focuses on one coal-burning facility’s strategy to meet ZLD requirements. The predominant source of liquid that will be treated by the proposed ZLD system is leachate from an active coal combustion residual (CCR) landfill. Is the ZLD’s design capacity suitable for average leachate flow conditions? Is there enough leachate storage volume to manage …

Ai-Guided Upcycling Of Coal Combustion Residues In Blended Cement And Concrete, Hongyan Ma

World of Coal Ash Proceedings

Coal combustion residues (CCRs), including fly ash, bottom ash, desulfurization gypsum, etc., on specification or off-specification, remain an abundant yet underutilized byproduct of power generation. While these materials have long been considered as supplementary cementitious materials (SCMs), their variable chemical and physical characteristics limit broader adoption in blended cement and concrete. This study introduces an AI-guided framework to accelerate the upcycling of CCRs into high-performance construction materials. By integrating materials informatics, machine learning models, and experimental validation, the framework enables rapid property prediction and performance-based preprocessing recommendation or mix design optimization for diverse CCR sources. Preliminary results demonstrate the ability …