Digital Commons Network^™

Virus-Like Particle Peptoid Conjugate As A Triple-Negative Breast Cancer Targeting Delivery System, Ricky Zhu

Chemistry Theses

Triple-negative breast cancer (TNBC), an aggressive form of breast cancer, characterized by its lack of estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptors (HER2) poses a therapeutic challenge as common treatment options are rendered ineffective. Here is a strategy to develop a drug delivery system utilizing poly-glycinated LC129 8, a TNBC targeting peptoid, covalently attached to HK97 virus-like particles (VLP) containing a C-terminal LPETG sequence via a sortase mediated reaction. Using the properties of the cage-like structure of VLPs and the TNBC specificity of the LC129-8, high doses of chemotherapy can be efficiently loaded into the …

Exploring The Biological Basis For Exercise Neuroprotection In Parkinson’S Disease: A Cross-Sectional Study Of Exercise And Physical Activity On Inflammatory Cytokines And Neurotrophins, Leah Isabelle P. Alegre, Jacob M. Brewer, Adeline Florschutz, Kate E. Hamiltonthompson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Regular exercise and physical therapy are known to increase production of neurotrophins, including brain-derived neurotrophic factor (BDNF), and anti-inflammatory cytokines. These changes combine to theoretically protect and slow the progressive loss of neurons in Parkinson’s disease (PD). The purpose of this study was to examine the effect of exercise and physical activity on various anti-inflammatory and pro-inflammatory cytokines and neurotrophins in people with PD (PwP). This was a cross-sectional design involving PwP (n=37), aged 43-85 years, who participated in two 30-minute bouts of exercise (with brief rest breaks during and pre/post blood draws) separated by a week. Measures collected prior …

Anatomy Academy: An Interdisciplinary Approach To Enhancing Youth Health Literacy, Roselle Antikoll, Jonathan Nakamine, Jessica Tran

UNLV Theses, Dissertations, Professional Papers, and Capstones

To enhance health literacy among the underserved youth population in Las Vegas, Nevada, Anatomy Academy (AA) is an eight-week, seven-lesson program that educates students through structured and interactive lesson plans covering basic anatomy, physiology, and nutrition. Our program was implemented in three different Title-I elementary schools between five different classrooms across Las Vegas. These lesson plans highlighted specific body systems including the cardiovascular, musculoskeletal, and gastrointestinal systems. Our primary aim was centered around involvement of more interdisciplinary healthcare professions including occupational therapy, dental medicine, osteopathic medicine, and nutrition to aid in the delivery of the AA program. Our secondary aim …

Postural And Load Dependent Modulation Of Lower Limb H-Reflex Excitability After Stroke, Daniel Bamiro, Matthew Berdiago, Ethan Hunter, Tia Nguyen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis

Leg stiffness is regulated by reflexive, intrinsic, and passive mechanisms, which are influenced by posture, body weight loading, and motor task demands. After a stroke, the capacity to modulate these mechanisms is often compromised. The H-reflex is a widely used electrophysiological tool to assess the excitability of the Ia afferent pathway within spinal circuitry. Although prior studies in healthy individuals have examined limb loading effects, results have been variable, and the role of postural and loading changes during standing remains underexplored, particularly in individuals post-stroke. This study investigated how different postural and limb loading conditions, specifically prone, standing, and …

Effect Of An Exercise Protocol On Balance In Adults With Down Syndrome, Juan Bernal, Natalie Sato

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis: Down syndrome (Ds) is a complex genetic condition that can impact multiple systems of the body, including functional balance. Ds-specific impairments such as muscle hypotonia, ligamentous laxity, and decreased muscle strength, coupled with a sedentary lifestyle can result in poor motor control, altered proprioceptive function, static and dynamic instability. Visual and vestibular impairments are also common in this population, increasing fall risk and fear of falling, and discouraging participation in physical activity. The aim of this study is to analyze the impact of a physical therapy-based exercise program on the functional balance of adults with Ds.

Number of Subjects: …

Feasibility Of A Functional Reach Tool For Individuals With Lower Extremity Amputations, Neil Bongolan, Dustin Hoy, Ashlyn Strange

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose: Patients with lower extremity amputations are at increased risk of falls due to decreased balance ability between amputated and sound side. The purpose of this study was to examine the usefulness of a reaching tool for practitioners to assess balance in an inpatient rehab facility. It was anticipated that clinicians will find the reaching device useful when administering the Functional Reach Test (FRT) in a clinical setting, given the frequent use of these assessments and the device’s demonstrated reliability.

Participants: Physical Therapists and patients at an Inpatient Rehab Facility in Henderson, Nevada

Materials/Methods: A prototype reaching tool was provided …

Uneven Terrain Treadmill Training For Lower Limb Prosthesis Users: A Feasibility Study, Brian Diep, Keegan Feroah, Ani Gasparyan, Nevena Jovanovic

UNLV Theses, Dissertations, Professional Papers, and Capstones

Individuals with lower limb amputation (LLA) face an increased risk for falls which may limit mobility, confidence, and participation in daily activities. Current rehabilitation programs for this population rarely integrate surface training as an intervention, despite walking on different surfaces being a necessity to participate in the real world. This feasibility study aimed to evaluate the practicality, acceptability, and preliminary efficacy of an uneven treadmill training protocol for individuals with LLA. Five adults with LLA (P1: transfemoral, 38 years old, 1.75 m, 88.8 kg; P2: hip disarticulation, 38 years old, 1.60 m, 106.7 kg; P3: transfemoral, 53 years old, 1.81 …

The Yorp Effect In Reboundx, Kaelyn Clement

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Yarkovsky-O’Keefe-Radzievskii-Paddack (YORP) effect is a radiation-induced torque that can affect the spin and rotational obliquity of small bodies. It has been observed to alter the rotation rate of asteroids in the Solar System (Lowry et al. 2007; Taylor et al. 2007). Under extreme circumstances, YORP can cause a body to fragment, inducing a cascade of fissions. This effect may be important in driving the pollution of white dwarf atmospheres in conjunction with other radiative forces. I developed a YORP calculator for REBOUNDX (Tamayo et al. 2020), an extensional library to the N-body integrator REBOUND (Rein & Liu 2012). I …

The Dehumanization Of Nfl Players In The Media, Destiny D. Farley

UNLV Theses, Dissertations, Professional Papers, and Capstones

This creative thesis aims to bridge the gap in sports journalism by humanizing National Football League (NFL) players, showcasing their lives outside of sports, and exploring their nuanced relationships with the media. NFL players are objectified in the press in a variety of ways, with some common themes including coverage of drafting/trading, performance statistics, salary/contracts, and their overall celebrification. Through an episodic visual narrative podcast, the project grants autonomy back to the players by providing them with a platform to showcase their personalities, discuss media experiences, and share untold stories. This podcast series—featuring a blend of A-roll and B-roll—immerses audiences …

Volunteer Experiences In Outdoor Recreation: Navigating Uncertainty And Belonging, Morgan R. Purdy

UNLV Theses, Dissertations, Professional Papers, and Capstones

Volunteers play a central role in the operation of outdoor recreation areas, yet their positions often lack formal training, clear authority, and consistent structural guidance. While organizational socialization research has focused primarily on paid employees, less is known about how volunteers in outdoor contexts navigate uncertainty and develop identity through communication. Guided by organizational socialization theory and volunteer communication scholarship, this qualitative study examines two research questions: How do outdoor recreation volunteers manage uncertainty during socialization? And how does volunteering shape their sense of identity and belonging? Drawing on 13 semi-structured interviews and prolonged ethnographic fieldwork within a public land …

Digital Society: Media And Mental Health, James P. Sims

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis examines how contemporary media environments especially algorithmic, mobile, and socially interactive platforms are shaping attention, identity, emotional regulation, and mental health in a mediatized society. While research has documented rising levels of anxiety, depression, social comparison, compulsive media use, and fragmented communication patterns, much of the existing scholarship is quantitative and clinical, leaving a gap in how individuals experience these effects subjectively. This project combines literature grounded in media effects theory with a qualitative documentary film featuring lived-experience narratives from media users, clinicians, and scholars. The thesis argues that the psychological, social, and behavioral outcomes associated with digital …

A Cross-Cultural Analysis Of Mukbang Influencers In China And The United States: Food, Identity, And Cultural Values, Anni Zhang

UNLV Theses, Dissertations, Professional Papers, and Capstones

Mukbang, a type of online eating broadcast which originated in South Korea, has become a widely popular form of digital media practice across different platforms. Although existing studies have examined Mukbang from perspectives such as audience psychology, health concerns, and platform economies, fewer studies have focused on how Mukbang influencers communicate cultural meanings and identity through food-related media contents in different cultural contexts. To address this gap, this study conducts a cross-cultural analysis of Mukbang influencers in China and the United States, focusing on how food, identity, and cultural values are represented in digital media environments.

This research adopts an …

Enhanced And Confused: The High Price Of Partnership In American Theater, Brandan Walsh

Student Theses

Broadway’s contemporary development ecosystem relies on a complex and increasingly fragile relationship between nonprofit regional theaters, Equity workshop models in New York City, and a small number of fully commercial out-of-town tryouts. In recent decades, nonprofit regional theaters have become central to the commercial development process, hosting fully staged productions of Broadway-bound work under a banner of artistic partnership. These institutions provide infrastructure, audiences, labor, and institutional credibility, absorbing reputational risk in hopes of high rewards and financial gain from donors. In return, they receive limited financial participation in downstream commercial success and operate under strict ethical and legal constraints …

Proceedings Of The 18th Indonesian Occupational Medicine Update (Iomu) 2026 - Occupational Medicine Without Borders: Emerging Risks, Evolving Workforces, And Inclusive Collaboration, Indonesian Association Of Occupational Medicine Specialists (Perhimpunan Kedokteran Okupasi Indonesia / Perdoki)

Occupational and Environmental Medicine Journal of Indonesia

This Supplemental Issue of the Occupational and Environmental Medicine Journal of Indonesia (OEMJI) compiles the scientific abstracts presented at the 18th Indonesian Occupational Medicine Update (IOMU) 2026, convened in Surabaya, Indonesia, from 15 to 17 May 2026. The IOMU has matured into the most prominent annual scientific platform of the Indonesian occupational medicine community, hosted by the Indonesian Association of Occupational Medicine Specialists (Perhimpunan Kedokteran Okupasi Indonesia / PERDOKI). Since its inception, the conference has served as a meeting point where clinicians, academics, industrial hygienists, regulators, employers, and worker representatives gather to translate emerging scientific evidence into …

Micromagnetic Simulations Of Field-Driven Antiferromagnetically Coupled Skyrmions, Aidan D. Kirk

Physics and Astronomy Honors Papers

Competing magnetic interactions can stabilize smooth magnetization textures and can be characterized by a topological winding number. A specific spin configuration/texture, spatially localized within a two-dimensional plane, is commonly known as a skyrmion. On the classical level, the significance of skyrmions for condensed matter physics and their potential for applications, ranging from spintronic devices to qubits, has been intensely investigated in recent years. This thesis focuses on antiferromagnetically (AF) coupled Neel-type magnetic skyrmions, which are comprised of two skyrmions with opposite topological charges, yielding a net topological charge of 0. This configuration results in the cancellation of their respective Magnus …

David "Dave" Bruce Papers, 1983-1995, David Bruce Jackson

Center for Restoration Studies Archives, Manuscripts and Personal Papers Finding Aids

No abstract provided.

Weighted Blankets: Implementation Of A Quality Improvement Pilot Project In The Neurosciences Intensive Care Unit, Anita Musafar

Doctoral Projects

The weighted blanket quality improvement pilot project was implemented at Stanford Healthcare (SHC) to address the limited number of nonpharmacological interventions available for agitation management in the critical care setting. Patients within the Neurosciences ICU (NSICU) at SHC are clinically complex and uniquely vulnerable to experiencing agitation. The objectives of this initiative were to understand nurses' perceptions surrounding weighted blanket use in the critical care setting and assess whether there was a decrease in Richmond Agitation-Sedation Scale (RASS) scores with this intervention. From September 2025 to December 2025, the nurses within the NSICU implemented the use of weighted blankets for …

Oxidized Lipids Are Inflammatory Danger Signals. The Hydrolytic Enzyme Carboxylesterase 1 Regulates Their Metabolic Fate, Thereby Shaping Macrophage Phenotype., Oluwabori Adekanye

Theses and Dissertations

Macrophages originate from hematopoietic progenitors they are immune cells, part of innate immunity. They patrol tissues to identify damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) from microorganisms. Macrophage pattern recognition receptors (PRRs) detect these signals, and respond by secreting lipid mediators, cytokines, and chemokines, thereby initiating the inflammatory response. Carboxylesterases (CES) belong to the α/β-hydrolase fold family of proteins and catalyze the hydrolysis of ester-containing substrates into alcohols and carboxylic acids. CES1 is one of the six CES identified in the human genome. They are localized in the endoplasmic reticulum lumen and cytosol of cells, primarily expressed in …

Impacts Of Structural Design On Oyster Survival And Predation In Restored Oyster Reefs, Jaden Akers

Theses and Dissertations

Restoration efforts are critical to ensure healthy oyster populations, but the high cost and marginal success rate of many restoration efforts demonstrates the need to evaluate alternative oyster reef restoration designs and strategies. To address this issue, I conducted a paired field and mesocosm study to assess the influence of structural design on oyster survival and predation. Results of the field portion of this study showed that oyster survival was greatest in short and bed-level (i.e., sitting on the sea bottom) reef designs. When assessing how design features impact oyster drill activity, elevated reefs (i.e., elevated above the sea bottom) …

Machine Learning-Based Decision Support Models With Applications In Postsecondary Education, Marco Paolo Anglesio

Theses and Dissertations

This dissertation investigates the deployment of machine learning methodologies in an industrial engineering framework for the development of advanced decision support systems in the context of enrollment management. Drawing on techniques from educational data mining, the research addresses three key phases in the lifecycle of traditional and non-traditional students. First, it analyzes student retention using predictive classification models designed to identify individuals at elevated risk of attrition. Second, it employs temporal convolutional networks for time series forecasting, estimating aggregate enrollment levels over highly variable, finite planning horizons on the basis of partially observed data and using an asymmetric loss function. …

The South Got Somethin' To Say!: Black Student Affairs Professionals Sustaining Equity Work Amid Dei Dismantling, Jaborius D. Ball

Theses and Dissertations

Scholarship within the academy extensively interrogates the realities of Black faculty but neglects the lived experiences of Black Student Affairs Professionals (BSAPs). This omission renders BSAPs labor and experiences institutionally invisible while reinforcing the narrative of equity work being a racial obligation pushed on Black professionals rather than institutional responsibility. Although representing 15% of the higher education workforce, this gross percentage is disproportionately concentrated in lower-paying, non-exempt staff positions (e.g., service, office/clerical) rather than in decision-making authority (CUPA-HR, 2025). Despite structural marginalization and inconsistencies, institutions rely on Black professionals to bear the brunt of racialized equity labor work classified as …

The Development And Evaluation Of An Automated Tactical Tillage Tool To Identify And Control Weeds In Row-Crop Production Systems Using Vision-Based Machine Learning., Clara Anne Cobb

Theses and Dissertations

Controlling in-field weeds in row-crop production systems is vital to the success of the operation. To control weeds, most producers use combinations of weed control strategies, including tillage and herbicide applications. Cotton production operations across the country have been trending toward conservation tillage practices in an effort to minimize soil disruption and maintain crop residues on the soil surface. This practice, in addition to the adoption of herbicide-tolerant cotton varieties, has encouraged more use of chemical herbicides. The overuse of these herbicides has resulted in an increase in herbicide-resistant weeds, making weed control difficult for farmers. This research aimed to …

British Subjects "Of Ye Jewish Religion": The Negotiated Identities Of The Levy-Franks Family, Laura Miriam Drake

Theses and Dissertations

Through a series of determined choices over sixty-five years, the Levy-Franks family blended their religious identity as Jews with their claimed British socio-political identity to achieve economic success in eighteenth-century colonial New York. Through colonial records, newspapers, legal petitions, portraits and, most significantly, the letters of Abigaill Levy Franks, this dissertation examines the family’s actions taken to create a blended identity, despite the potential threat that their participation in the broader British Atlantic world posed to their religious selves. During a time in British history when religious identities were at the forefront of political debate, the Levy-Franks family created a …

Patterns Of Molecular Evolution Driving Reproductive And Genomic Processes In Sauropsids, Taylor Green

Theses and Dissertations

Sexual reproduction is an important driver of genetic diversity and speciation through such forces as selection, mutation, and drift. Sauropsids are an appropriate clade to study shared molecular drivers of sexual and genomic evolution due to their genome architecture, sex determination mechanism (SDM) plasticity, and large syntenous genomic regions. Using comparative phylogenetic methods, I identify predictable patterns of selection in meiotic recombination genes and clade-specific drivers of recombination rate evolution. Then, leveraging whole genome sequencing, I demonstrate that American alligator genomes are characterized by an ancient loss of genetic diversity driven by drift and historic inbreeding. I also generate a …

Assessment Of Energy And Hydration Demands Of Farm Workers In Mississippi, Mckenzie Lynne Hargrove

Theses and Dissertations

The agricultural community in Mississippi is critical to the state’s economy and the health of its communities. Farm workers meet these needs by performing highly demanding work with long hours of labor, limited resources, and stressful environmental conditions. The purpose of this investigation was to examine and measure indicators of physiological and behavioral adaptations to the heat such as whole body sweat rate (WBSR), sweat sodium (Na+) content, urine specific gravity (USG), and fluid intake, as well as determine total daily energy expenditure (TEE) and water influx (rH2O) via the doubly labeled water technique (DLW) in farm workers during the …

Adaptive Channel Switching For Contention Resolution, Shafqat Hasan

Theses and Dissertations

Contention resolution is a fundamental problem in distributed computing, where multiple devices compete to transmit over a shared channel without centralized coordination. Classical models typically assume a single always-available channel and focus on minimizing makespan. However, modern wireless systems increasingly operate under spectrum-sharing frameworks in which access to high-capacity spectrum is opportunistic and may be interrupted by higher-priority users. These settings introduce new challenges, including asymmetric channel speeds, adversarially scheduled evictions, and non-trivial switching costs. In this thesis, we study contention resolution in a dual-channel model consisting of a slow, always-available channel and a faster channel subject to adversarially scheduled …

A Research-Informed Wellness Guide For Creating A Culture Of Educator Wellness And Retention In Schools, Anthony L. Herbert

Theses and Dissertations

Teacher attrition in high-poverty K–12 schools continues to undermine instructional continuity, organizational stability, and educational equity. While compensation and accountability pressures contribute to turnover, emerging research identifies workload intensity, emotional exhaustion, and the absence of systemic wellness supports as central drivers of burnout and departure decisions. The purpose of this capstone project is to develop a research-informed wellness guide designed to assist site-based leaders in embedding educator wellness within school systems as a strategic approach to improving teacher retention. This study addresses the question: What leadership strategies and school-level practices does the research recommend for creating supportive, wellness-centered environments in …

Developing And Evaluating U.S. Army Bridging For Ship Simulation, Jacob C. Hodges

Theses and Dissertations

This research investigates the intricacies of ship simulation and developmental processes for integrating wet gap crossing capabilities into a simulated environment. The US Army Mark III Bridge Erection Boat (BEB) and Improved Ribbon Bridge (IRB) were modeled in commercial off the shelf (COTS) and Government Co-Owned (GCO) navigation software suites to determine their performance capabilities and limitations. Each model was constructed using naval architecture concepts to accurately capture their hydrostatic and hydrodynamic effects before being validated against available performance data and expert elicitation from expert US Army watercraft operators. Models were configured and tested in simulated river flows with current …

Mapping And Measuring Sidewalk Network Connectivity In Starkville, Mississippi: The Role Of Policy-Required Development, Public Investment, And Destination Access, Isabella R. Jones

Theses and Dissertations

Sidewalks support pedestrian mobility, public health, social community, and access to destinations, but few studies explore sidewalk connectivity in small cities. This study examines changes in sidewalk network connectivity in Starkville, Mississippi after the adoption of a sidewalk ordinance in 2009. Using ArcGIS Pro, a dataset of the city’s sidewalk network was created and used to analyze changes in the network between 2009 and 2024. Sidewalks were given connectivity ratings using a system that considered physical connections to the network as well as proximity to important destinations such as grocery stores, parks, schools, bus stops, and the city’s hospital. The …

Accelerating Defensive Cyber Operations Via Unsupervised Log Clustering And Automated Regex Template Synthesis, Charles Matthew Jones

Theses and Dissertations

Modern Security Operations Centers (SOCs) ingest millions of log entries per day, but manual parsing does not scale to the volume, heterogeneity, and rapid evolution of log formats. This dissertation investigates whether unsupervised clustering can automate the generation of candidate field-extraction templates while remaining deployable in production and feasible under realistic runtime and memory constraints. The central research question asks whether a machine-learning-assisted pipeline that proposes extraction templates for security engineer review—relative to reproducible human-authored baselines such as hand-written regular expressions—can measurably improve rule-set deployability and corpus-scale extraction quality. Improvement is quantified using four applicability metrics: Coverage Rate (CR), Exclusive …