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Steeper Size Spectra With Decreasing Phytoplankton Biomass Indicate Strong Trophic Amplification And Future Fish Declines, Angus Atkinson, Axel G. Rossberg, Ursula Gaedke, Gary Sprules, Ryan F. Heneghan, Stratos Batziakas, Maria Grigoratou, Elaine Fileman, Katrin Schmidt, Constantin Frangoulis Jan 2024

Steeper Size Spectra With Decreasing Phytoplankton Biomass Indicate Strong Trophic Amplification And Future Fish Declines, Angus Atkinson, Axel G. Rossberg, Ursula Gaedke, Gary Sprules, Ryan F. Heneghan, Stratos Batziakas, Maria Grigoratou, Elaine Fileman, Katrin Schmidt, Constantin Frangoulis

School of Geography, Earth and Environmental Sciences

Under climate change, model ensembles suggest that declines in phytoplankton biomass amplify into greater reductions at higher trophic levels, with serious implications for fisheries and carbon storage. However, the extent and mechanisms of this trophic amplification vary greatly among models, and validation is problematic. In situ size spectra offer a novel alternative, comparing biomass of small and larger organisms to quantify the net efficiency of energy transfer through natural food webs that are already challenged with multiple climate change stressors. Our global compilation of pelagic size spectrum slopes supports trophic amplification empirically, independently from model simulations. Thus, even a modest …


Development Of A Suspended Aerobic Membrane Bioreactor (Sambr) For Sustainable Wastewater Treatment On Early Planetary Bases, Talon James Bullard Jan 2024

Development Of A Suspended Aerobic Membrane Bioreactor (Sambr) For Sustainable Wastewater Treatment On Early Planetary Bases, Talon James Bullard

USF Tampa Graduate Theses and Dissertations

Environmental Control and Life Support Systems (ECLSS) ideally should treat all “waste” streams for recovery in a sustainable and near closed-loop manner. This will be critical for Partial Gravity Habitats (PGH) and Early Planetary Bases (EPB) that will be established on the Moon and Mars due to the lack of readily available resources. Currently, the Water Recovery System (WRS), onboard the International Space Station (ISS), recovers and purifies water from urine and graywater. While efficient, this system is not optimized for future missions and utilizes physical-chemical technologies that operate with single-use and hazardous consumables. In response to the lack of …


Arab Journalists Have No Place: Authorities Use Digital Surveillance To Control Investigative Reporting, Miral Sabry Alashry Jan 2024

Arab Journalists Have No Place: Authorities Use Digital Surveillance To Control Investigative Reporting, Miral Sabry Alashry

Faculty Journal Articles

The purpose of this study was to investigate the extent of digital surveillance by Arab authorities, who face risks and threats of surveillance, and how journalists seeking press freedom use tools and techniques to communicate securely, such as open source in journalism. These journalists share and rely heavily on an opensource data ideology. With novel methods and tools, they integrate a new set of actors, competencies, and technologies into journalistic practice, renegotiating and transcending professional boundaries. The methodology of the study was based on in-depth interviews from Egypt, Yemen, Syria, Lebanon, Jordan, Libya, and Tunisia with a selection of journalists …


Cell Membrane-Anchored And Tumor-Targeted Il-12 T-Cell Therapy Destroys Cancer-Associated Fibroblasts And Disrupts Extracellular Matrix In Heterogenous Osteosarcoma Xenograft Models, Jiemiao Hu, Alexander J Lazar, Davis Ingram, Wei-Lien Wang, Wendong Zhang, Dristhi Ragoonanan, Xueqing Xia, Kris Mahadeo, Richard Gorlick, Shulin Li Jan 2024

Cell Membrane-Anchored And Tumor-Targeted Il-12 T-Cell Therapy Destroys Cancer-Associated Fibroblasts And Disrupts Extracellular Matrix In Heterogenous Osteosarcoma Xenograft Models, Jiemiao Hu, Alexander J Lazar, Davis Ingram, Wei-Lien Wang, Wendong Zhang, Dristhi Ragoonanan, Xueqing Xia, Kris Mahadeo, Richard Gorlick, Shulin Li

Faculty, Staff and Student Publications

Background: The extracellular matrix (ECM) and cancer-associated fibroblasts (CAFs) play major roles in tumor progression, metastasis, and the poor response of many solid tumors to immunotherapy. CAF-targeted chimeric antigen receptor-T cell therapy cannot infiltrate ECM-rich tumors such as osteosarcoma.

Method: In this study, we used RNA sequencing to assess whether the recently invented membrane-anchored and tumor-targeted IL-12-armed (attIL12) T cells, which bind cell-surface vimentin (CSV) on tumor cells, could destroy CAFs to disrupt the ECM. We established an in vitro model of the interaction between osteosarcoma CAFs and attIL12-T cells to uncover the underlying mechanism by which attIL12-T cells penetrate …


Toward Standardization, Harmonization, And Integration Of Social Determinants Of Health Data: A Texas Clinical And Translational Science Award Institutions Collaboration, Catherine K Craven, Linda Highfield, Mujeeb Basit, Elmer V Bernstam, Byeong Yeob Choi, Jonathan A Gelfond, Vaishnavi Kannan, Paula K Shireman, Heidi Spratt, Kayla J Torres Morales, Chen-Pin Wang, Zhan Wang, Meredith N Zozus, Edward C Sankary, Susanne Schmidt Jan 2024

Toward Standardization, Harmonization, And Integration Of Social Determinants Of Health Data: A Texas Clinical And Translational Science Award Institutions Collaboration, Catherine K Craven, Linda Highfield, Mujeeb Basit, Elmer V Bernstam, Byeong Yeob Choi, Jonathan A Gelfond, Vaishnavi Kannan, Paula K Shireman, Heidi Spratt, Kayla J Torres Morales, Chen-Pin Wang, Zhan Wang, Meredith N Zozus, Edward C Sankary, Susanne Schmidt

Faculty, Staff and Student Publications

INTRODUCTION: The focus on social determinants of health (SDOH) and their impact on health outcomes is evident in U.S. federal actions by Centers for Medicare & Medicaid Services and Office of National Coordinator for Health Information Technology. The disproportionate impact of COVID-19 on minorities and communities of color heightened awareness of health inequities and the need for more robust SDOH data collection. Four Clinical and Translational Science Award (CTSA) hubs comprising the Texas Regional CTSA Consortium (TRCC) undertook an inventory to understand what contextual-level SDOH datasets are offered centrally and which individual-level SDOH are collected in structured fields in each …


Prediction Of Hydrogel Degradation Time Based On Central Composite Design, Manlai Zhang, Xiaohui Li Jan 2024

Prediction Of Hydrogel Degradation Time Based On Central Composite Design, Manlai Zhang, Xiaohui Li

Faculty, Staff and Student Publications

In this study, a self-degrading hydrogel was formed by free-radical-initiated copolymerization, which can be used for oil and gas well strip pressure operations. Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (1H NMR), scanning electron microscopy (SEM), and thermogravimetry-mass spectrometry (TGA-MS) were used to study the reaction mechanism as well as the microstructure of the gels. Then, the effects of the four factors and their interactions on gel degradation time were determined by central composite design (CCD). Then, the effects of copolymer concentration, cross-linker, initiator, and reaction temperature and their interactions on gel degradation time were determined by central composite …


Clpfudatabase: A Suite Of R Packages For Energy Conversion Chain Analysis, Matthew Kuperus Heun, Zeke Marshall, Emmanuel Aramendia Jan 2024

Clpfudatabase: A Suite Of R Packages For Energy Conversion Chain Analysis, Matthew Kuperus Heun, Zeke Marshall, Emmanuel Aramendia

University Faculty Publications and Creative Works

Energy flowing through societal energy conversion chains (ECCs) enables economic activity and facilitates human flourishing. To understand economic growth and human well-being, the field of societal energy analysis (Common, 1976) evaluates ECCs from the primary stage (resources extracted from the environment, such as coal, oil, natural gas, wind, and solar), to the final stage (energy purchased by consumers, such as refined petroleum and electricity), to the useful stage (energy desired by the end user, such as heat, motion, and light), and sometimes to energy services (such as thermal comfort, transport, and illumination). Societal exergy analysis (SEA) (Ertesvåg, 2001), an extension …


January 9, 2024 Ereporter, University Of Alabama At Birmingham Jan 2024

January 9, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


The Experience Of Physical Recovery And Physical Rehabilitation Following Hospital Discharge For Intensive Care Survivors—A Qualitative Systematic Review, Sian Goddard, Hilary Gunn, Bridie Kent, Rachel Dennett Jan 2024

The Experience Of Physical Recovery And Physical Rehabilitation Following Hospital Discharge For Intensive Care Survivors—A Qualitative Systematic Review, Sian Goddard, Hilary Gunn, Bridie Kent, Rachel Dennett

School of Health Professions

Background: Over 120,000 people in the UK survive critical illness each year, with over 60% of these experiencing mobility issues and reduced health-related quality of life after discharge home. This qualitative systematic review aimed to explore critical care survivors’ perceptions, opinions, and experiences of physical recovery and physical rehabilitation following hospital discharge. Methods: This review followed the Joanna Briggs Institute (JBI) methodology with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and was conducted between January 2020 and June 2022. The search was conducted using the following databases: Embase, CINAHL, Medline Ovid, Cochrane, and the Joanna Briggs Institute, …


Age-Related Differences In Motor Skill Transfer With Brief Memory Reactivation, Kylie B Tomlin, Brian P Johnson, Kelly P Westlake Jan 2024

Age-Related Differences In Motor Skill Transfer With Brief Memory Reactivation, Kylie B Tomlin, Brian P Johnson, Kelly P Westlake

2020-Current year OA Pubs

Motor memories can be strengthened through online practice and offline consolidation. Offline consolidation involves the stabilization of memory traces in post-practice periods. Following initial consolidation of a motor memory, subsequent practice of the motor skill can lead to reactivation and reconsolidation of the memory trace. The length of motor memory reactivation may influence motor learning outcomes; for example, brief, as opposed to long, practice of a previously learned motor skill appears to optimize intermanual transfer in healthy young adults. However, the influence of aging on reactivation-based motor learning has been scarcely explored. Here, the effects of brief and long motor …


The Immune System And Metabolic Products In Epilepsy And Glioma-Associated Epilepsy: Emerging Therapeutic Directions, Craig M Horbinski, Jessica W Templer, Joshua M Rosenow, Timothy L Sita, Charles D James, Benjamin Deneen, Stephen D Miller, Amy B Heimberger Jan 2024

The Immune System And Metabolic Products In Epilepsy And Glioma-Associated Epilepsy: Emerging Therapeutic Directions, Craig M Horbinski, Jessica W Templer, Joshua M Rosenow, Timothy L Sita, Charles D James, Benjamin Deneen, Stephen D Miller, Amy B Heimberger

Faculty, Staff and Students Publications

Epilepsy has a profound impact on quality of life. Despite the development of new antiseizure medications (ASMs), approximately one-third of affected patients have drug-refractory epilepsy and are nonresponsive to medical treatment. Nearly all currently approved ASMs target neuronal activity through ion channel modulation. Recent human and animal model studies have implicated new immunotherapeutic and metabolomic approaches that may benefit patients with epilepsy. In this Review, we detail the proinflammatory immune landscape of epilepsy and contrast this with the immunosuppressive microenvironment in patients with glioma-related epilepsy. In the tumor setting, excessive neuronal activity facilitates immunosuppression, thereby contributing to subsequent glioma progression. …


Recommendations To Solve The Problem Of Increased Referrals At The Escambia County Alternative School In Flomaton, Alabama, Ronda Hoffman Jan 2024

Recommendations To Solve The Problem Of Increased Referrals At The Escambia County Alternative School In Flomaton, Alabama, Ronda Hoffman

Doctoral Dissertations and Projects

The purpose of this research study was to provide recommendations to solve the problem of increased referrals at the Escambia County Alternative School in Flomaton, Alabama. The problem was the number of referrals on file at Escambia County Alternative School increased by 50% from November/December 2021 to January/February 2022. The rationale for this study was the referrals written can impact the students in more ways than the given discipline. The central research question was, How can the problem of increased referrals be solved at the Escambia County Alternative School? Three forms of data collected for this applied research included qualitative …


The Effects Of Social Gratitude On Anxiety, Depression, And Persistence To Graduate Among College Students, Terrie L. Hilbun Jan 2024

The Effects Of Social Gratitude On Anxiety, Depression, And Persistence To Graduate Among College Students, Terrie L. Hilbun

Doctoral Dissertations and Projects

Anxiety and depression have become increasingly prevalent among college students, leading to negative consequences such as decreased persistence to graduate. This study’s goal was to research the effects of a two-week gratitude intervention on attitude health, focusing on gratitude, depression, anxiety, and persistence of college students. The participants were drawn from a convenience sample of community college students located in northeast Alabama. A single pre-and post-test design was utilized, to compare the effects of a social gratitude intervention on gratitude, anxiety, depression, and persistence. A total of 25 volunteers, aged 18 or older, participated. It was hypothesized that there would …


Exploring The Relationship Between Staffing And Long-Term Care Worker Mental Health, Matthew R. Trombley Jan 2024

Exploring The Relationship Between Staffing And Long-Term Care Worker Mental Health, Matthew R. Trombley

Doctoral Dissertations and Projects

This research delves into the relationship between staffing levels during a crisis in the healthcare workforce and the mental well-being of long-term care workers, with a specific focus on variables such as burnout, compassion fatigue, and compassion satisfaction. With increasing workforce shortages, the attention to providing quality care during this tumultuous period has become increasingly urgent. There has been scarce empirical research that has explicitly sought to comprehend the connection between staffing levels and the mental health of long-term care professionals. This study was designed as a non-experimental, quantitative correlational investigation, aiming to understand the intricate dynamics between patient-to-staff ratios …


Parameters Of Need For Loved Ones Of Addicts Following Overdose Bereavement, Adrienne Nichole Weiss Jan 2024

Parameters Of Need For Loved Ones Of Addicts Following Overdose Bereavement, Adrienne Nichole Weiss

Doctoral Dissertations and Projects

This research pairs past evaluation of aid for friends and families throughout the life of a loved one suffering opioid addiction and seeks to elicit the potential for further considerations for after-math care in the wake of overdose bereavement. Traumatic grief and secondary trauma in relation to individuals having suffered the loss of a loved one to opioid-related circumstances will be the framework focus to prove the need to engage a forgotten population of people. Considering the vast review of literature engaging the discussion of addiction as well as traumatic grief, this qualitative analysis takes on a newly woven perspective …


Effectiveness Of Emotionally Focused Therapy (Eft) With Chinese Couple Clients: From The Chinese Eft Therapists' Cultural Lens, Yifan Wang Jan 2024

Effectiveness Of Emotionally Focused Therapy (Eft) With Chinese Couple Clients: From The Chinese Eft Therapists' Cultural Lens, Yifan Wang

Doctoral Dissertations and Projects

The purpose of this phenomenological study is to understand the Chinese EFT (Emotionally Focused Therapy) therapists’ experiences of working with Chinese couples in EFT sessions, as well as to discover how the cultural factors play a role in the effectiveness of EFT use with Chinese couples. This study was conducted by finding out 10 EFT-oriented therapists and analyzing via online interviews their experiences of working with Chinese couples. The theories guiding this study are based on Emotionally Focused Therapy (EFT). One of the founding therapists of this approach is Dr. Sue Johnson. EFT is heavily influenced by attachment theory, which …


The Unprecedented Stressors Of Early Childhood Educators During The Covid-19 Pandemic And Post-Pandemic Restoration: A Case Study, Ida Mae Lewis Jan 2024

The Unprecedented Stressors Of Early Childhood Educators During The Covid-19 Pandemic And Post-Pandemic Restoration: A Case Study, Ida Mae Lewis

Doctoral Dissertations and Projects

The purpose of this case study was to describe the unprecedented stressors of early childhood educators (ECE) during the COVID-19 pandemic and the post-pandemic restoration at two early childhood education centers (ECEC) in a midwestern state. The central research question was: How did the COVID-19 pandemic’s unprecedented stressors impact ECE in the post-pandemic era? Data collection included structured interviews with open-ended questions, focus groups, and documents. The three data sources were triangulated for themes, perspectives, and interpretations, and coding was used to help gain a deep understanding of the stressors experienced by early childhood educators. The conceptual framework guiding this …


Choral Educators’ Perspectives On Block Scheduling In Middle Schools, Heather Anderson Perryman Jan 2024

Choral Educators’ Perspectives On Block Scheduling In Middle Schools, Heather Anderson Perryman

Doctoral Dissertations and Projects

The purpose of this study is to identify how common the practice of block scheduling is currently among American public middle schools. This study also determines the perspectives of choral music educators working in public middle schools with existing block schedules. More extant literature is needed to examine block scheduling practices at the middle school level and the possible effects of block scheduling on middle school choral programs. Such an examination is essential for ascertaining curriculum needs, staffing issues, scheduling challenges, and choral music education advocacy initiatives. A qualitative design and case study approach are utilized to infer connections between …


Using Interprofessional Collaboration To Bridge Athletic Training And Strength And Condition Programs In High School Settings To Reduce Injuries, Craig Hermans Jan 2024

Using Interprofessional Collaboration To Bridge Athletic Training And Strength And Condition Programs In High School Settings To Reduce Injuries, Craig Hermans

Doctoral Dissertations and Projects

The purpose of this practicum is to identify the differences between between the athletic training professional and the strength and conditioning professional in a school which may cause barriers in using interprofessional collaboration. Currently, the rate of reinjury in a student-athlete population is quite high due, in part, to the different focuses between athletic trainers and that of strength and conditioning coaches. This practicum prepares a compiled review of the literature of research as well as independent research evaluating the student/athletes’ recovery from injury in relation to reinjury. The findings from the research serve a purpose to establish a deeper …


Philosophies Of Empirical And Habitual Teaching: Healthy Vocal Methodologies In Higher Education For The Twenty-First Century, Katie Denise Osuamkpe Jan 2024

Philosophies Of Empirical And Habitual Teaching: Healthy Vocal Methodologies In Higher Education For The Twenty-First Century, Katie Denise Osuamkpe

Doctoral Dissertations and Projects

Despite research done on healthy vocal methodologies, there are continuous changes in how best to prepare collegiate music students, relating to their emotional health through empirical and habitual teachings. This study will show how healthy vocal methodologies can influence higher education vocal students of the twenty-first century. This qualitative study can build a bridge to related topics in an exploratory framework with perspectives on: Dr. William Hettler’s Emotional Well-Being and its seven dimensions, Jean Piaget's Cognitive Construction Theory, Peter Salovey and John Mayer's Emotional Intelligence Theory, Daniel Goleman’s Social Emotional Learning Methodology, Susan Brookhart’s “Classroometrics” Theory, Howard Gardner’s Theory of …


An Existential-Phenomenological Exploration Of The Experience Of Being A White Undergraduate Psychology Student In A Multicultural Counseling Course, Mona Lynnette Swallow Jan 2024

An Existential-Phenomenological Exploration Of The Experience Of Being A White Undergraduate Psychology Student In A Multicultural Counseling Course, Mona Lynnette Swallow

Doctoral Dissertations and Projects

This existential-phenomenological study sought to explore the experiences of White undergraduate psychology students enrolled in a multicultural counseling course to gain an understanding of how White students described their lived experiences while enrolled in the course. This was accomplished by conducting virtual interviews with nine participants recruited through an online university announcement. Three key experiential constituents emerged from the data supporting previous research of the conflicts White students experience as they process understanding their racialized identities as members of the dominant ethnic-racial group in U.S. society in context to the topics discussed in the course. This lack of understanding was …


Differences In Out-Of-School Suspensions Between Black And White High School Students When Controlling For Student Factors, School Factors, And Delinquency, Steven Craig Davidson Jan 2024

Differences In Out-Of-School Suspensions Between Black And White High School Students When Controlling For Student Factors, School Factors, And Delinquency, Steven Craig Davidson

Doctoral Dissertations and Projects

This quantitative, correlational study aims to determine how accurately out-of-school suspensions can be predicted from a linear combination of student delinquency, in-school delinquency, and prior suspensions for Black and White high school students. Further, a causal-comparative design is used to determine if there is a statically significant difference in out-of-school suspensions between Black and White high school students when controlling for student factors, school factors, and student delinquency factors. The study consists of five guiding theories that inform two general hypotheses. The first hypothesis, referred to as the differential selection hypothesis, is guided by critical race theory (CRT) and implicit …


Burnout Triggers In The Novice Registered Nurse, Sharon K. Nguyen Jan 2024

Burnout Triggers In The Novice Registered Nurse, Sharon K. Nguyen

Doctoral Dissertations and Projects

Nurse burnout has been strongly associated with decreased patient satisfaction and reduced retention rates in the novice registered nurse. This phenomenon is exacerbating the already rising global nursing shortage. A strong correlation is established between novice registered nurses who endure repeated or multiple triggers, such as unsafe staffing ratios, inadequate preceptorship, and ineffective leadership to those who succumb to burnout. Burnout is a significant problem in the United States, impacting how healthcare is perceived by the public. In 2019 there were more than six million nurses, making up the largest segment of the healthcare population and directly affecting the safety …


The Mental Health Effects Of Vicarious Trauma, Moral Injury, And Positive Religious Coping With Canine Comfort Handlers, Terri Jeanne O'Brien-Cross Jan 2024

The Mental Health Effects Of Vicarious Trauma, Moral Injury, And Positive Religious Coping With Canine Comfort Handlers, Terri Jeanne O'Brien-Cross

Doctoral Dissertations and Projects

The intention of this study was to examine whether positive religious coping buffered the mental health effects of vicarious trauma and moral injuries in canine comfort handlers. By examining whether positive religious coping would reduce symptoms of posttraumatic stress disorder (PTSD), a better understanding of the mental, emotional, and spiritual effects of volunteer handlers was discovered. Handlers work throughout their communities and deploy to crisis events such as mass shootings and natural disasters. By partnering with highly trained canines, they provide support and comfort to those in need. During these interactions, handlers are often exposed to traumatic situations and may …


Indirect Effects Of Self-Compassion On Self-Forgiveness Through Self-Esteem And Self-Condemnation With Gender Moderation: A Parallel Moderated Mediation Analysis, Jill A. Marin Jan 2024

Indirect Effects Of Self-Compassion On Self-Forgiveness Through Self-Esteem And Self-Condemnation With Gender Moderation: A Parallel Moderated Mediation Analysis, Jill A. Marin

Doctoral Dissertations and Projects

Two studies explored the relationship between self-compassion and self-forgiveness as well as the role of self-esteem, self-condemnation, and gender in that relationship. Since self-forgiveness is associated with greater well-being, the studies’ importance included gaining knowledge to increase well-being by investigating factors that contribute to self-forgiveness. Research questions were if the relationship between self-compassion and self-forgiveness was mediated by self-esteem and self-condemnation and if gender moderated those mediations. Two quantitative correlational studies, of 94 MTurk and 114 social media participants, used online Qualtrics surveys with established measurements to collect data. Associations, mediators, and moderators were examined by bivariate correlations, mediation analysis, …


Moral Disengagement And Psychopathy: A Quantitative Correlational Study On Attachment To God And Empathy, Kimberly Essler Jan 2024

Moral Disengagement And Psychopathy: A Quantitative Correlational Study On Attachment To God And Empathy, Kimberly Essler

Doctoral Dissertations and Projects

Moral disengagement and lack of empathy are rising concerns in the United States. Those who are morally disengaged or display limited empathy are often associated with anti-social personality disorder or psychopathy. Studies consistently show trauma and early childhood attachment are predictors for the development of behaviors associated with psychopathy. Current literature has demonstrated semi-effective therapeutic treatment and pharmacotherapy for comorbid disorders and symptoms such as anxiety. However, research fails to adequately address the prevention and treatment of lack of empathy – a major factor in the perilous behaviors of psychopathy. Psychopathy includes structural and functional brain abnormalities in the cortical …


Indirect Prophecies Concerning The Death Of Christ In Narrative, Lindsay A. Siemers Jan 2024

Indirect Prophecies Concerning The Death Of Christ In Narrative, Lindsay A. Siemers

Doctoral Dissertations and Projects

In Luke 24, two disciples recognized that Jesus had predicted He would suffer, be betrayed, and handed over to death by crucifixion, and had said He would rise again on the third day. It was now the third day, and Jesus was no longer in the tomb, but they were confused as to what these things meant and how they came to be. Jesus says to them, “‘O foolish ones and slow of heart to believe in all that the prophets have spoken! Ought not the Christ to have suffered these things and to enter into His glory?’ And beginning …


Integrating Genetic Regulation And Single-Cell Expression With Gwas Prioritizes Causal Genes And Cell Types For Glaucoma, Aboozar Monovarfeshani, Xinyi Jiang, Puja A Mehta, Jayshree Advani, Yuyang Luo, Qingnan Liang, Skanda Rajasundaram, Arushi Shrivastava, Katherine Duchinski, Sreekar Mantena, Jiali Wang, Tavé Van Zyl, Louis R Pasquale, Anand Swaroop, Puya Gharahkhani, Anthony P Khawaja, Stuart Macgregor, Rui Chen, Veronique Vitart, Joshua R Sanes, Janey L Wiggs, Ayellet V Segrè Jan 2024

Integrating Genetic Regulation And Single-Cell Expression With Gwas Prioritizes Causal Genes And Cell Types For Glaucoma, Aboozar Monovarfeshani, Xinyi Jiang, Puja A Mehta, Jayshree Advani, Yuyang Luo, Qingnan Liang, Skanda Rajasundaram, Arushi Shrivastava, Katherine Duchinski, Sreekar Mantena, Jiali Wang, Tavé Van Zyl, Louis R Pasquale, Anand Swaroop, Puya Gharahkhani, Anthony P Khawaja, Stuart Macgregor, Rui Chen, Veronique Vitart, Joshua R Sanes, Janey L Wiggs, Ayellet V Segrè

Faculty, Staff and Students Publications

Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However, its molecular and cellular causes are not well understood. Elevated intraocular pressure (IOP) is a major risk factor, but many patients have normal IOP. Colocalization and Mendelian randomization analysis of >240 POAG and IOP genome-wide association study (GWAS) loci and overlapping expression and splicing quantitative trait loci (e/sQTLs) in 49 GTEx tissues and retina prioritizes causal genes for 60% of loci. These genes are enriched in pathways implicated in extracellular matrix organization, cell adhesion, and vascular development. Analysis of single-nucleus RNA-seq …


Analisis Butir Soal Okupasi Terapi Pada Pediatri Menggunakan Software Klasika Dengan Pendekatan Classical Test Theory (Ctt), Reza Nur Arsyi, Hermito Gideon Jan 2024

Analisis Butir Soal Okupasi Terapi Pada Pediatri Menggunakan Software Klasika Dengan Pendekatan Classical Test Theory (Ctt), Reza Nur Arsyi, Hermito Gideon

Jurnal Vokasi Indonesia

Penelitian ini bertujuan untuk mendeskripsikan hasil analisis kualitas soal yang ada pada soal okupasi terapi pediatri dibutuhkan karena sebagai salah satu bahan evaluasi pengajaran dan evaluasi terhadap pengetahuan yang dimiliki oleh mahasiswa. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kuantitatif. Ujian terdiri dari 31 item yang diujikan pada 60 mahasiswa yang telah mendapatkan mata kuliah Okupasi Terapi pada pediatri, Evaluasi tersebut dianalisis dengan pendekatan classical test theory menggunakan software klasika. Hasil yang diperoleh dari penelitian klasika diperoleh nilai SEM 2,123, alpha 0,635, mean biserial 0,428, daya pembeda pada item diterima sebanyak 20, 4 item perlu direvisi/dicek dan 7 item ditolak. …


Hubungan Antara Fear Of Falling Dengan Aktivitas Fisik Pada Lansia Di Panti Jompo, Inez Deviantika, Farahdina Bachtiar, Ika Fitri Wulan Dhari, Andy Sirada Jan 2024

Hubungan Antara Fear Of Falling Dengan Aktivitas Fisik Pada Lansia Di Panti Jompo, Inez Deviantika, Farahdina Bachtiar, Ika Fitri Wulan Dhari, Andy Sirada

Jurnal Vokasi Indonesia

Pada lanjut usia (lansia), terjadinya perubahan fisik akan mempengaruhi proses aktivitas fisiknya. Salah satu faktor yang menjadi faktor terhambatnya aktivitas fisik adalah rasa takut jatuh, dimana hal ini dapat timbul dari pengalaman yang dirasakan lansia. Lansia akan menghindari aktivitas yang menimbulkan risiko jatuh bagi dirinya. Penelitian ini bertujuan untuk mengetahui hubungan antara fear of falling dan aktivitas fisik pada lansia. Penelitian ini menggunakan metode cross sectional dengan pendekatan korelasi di Panti Jompo Hajjah Andi Hasmah Noor Jakarta. Alat ukur yang digunakan dalam penelitian ini adalah Physical Activities Scale For Elderly (PASE-I) dan Modified Falls Efficacy Indonesian Scale (FES-I). Berdasarkan hasil …