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Reverse Takotsubo Cardiomyopathy With Severe Dengue: Case Report From Pakistan., Warda Ajmal, Zahra Iftikhar, Asaad Akbar Khan Jan 2024

Reverse Takotsubo Cardiomyopathy With Severe Dengue: Case Report From Pakistan., Warda Ajmal, Zahra Iftikhar, Asaad Akbar Khan

Journal of Community Hospital Internal Medicine Perspectives

Takotsubo Cardiomyopathy is an established transient cardiomyopathy found predominately in females with intense emotional and physical strain. It has four notable variants: Apical, Mid-Ventricular, Basal and Focal. Mid Ventricular variant is also referred to as Reverse Takotsubo Cardiomyopathy. Dengue is a viral arthopod-borne tropical disease endemic to Pakistan, with multiple reports of cardiovascular involvement. We report an atypical presentation of a 17 year old male, suffering from Dengue Fever, who presented to a tertiary care hospital with Reverse Takotsubo Cardiomyopathy.


Cases From A Community Hospital…Jchimp Series #2: 66-Year-Old Man With Recurrent Painful Rashes And Oral Ulcerations, Fatima Halilu, Jing Wu, Joseph Fuscaldo, Nathan Dunsmore, Zain Syed, Pauline Daley Jan 2024

Cases From A Community Hospital…Jchimp Series #2: 66-Year-Old Man With Recurrent Painful Rashes And Oral Ulcerations, Fatima Halilu, Jing Wu, Joseph Fuscaldo, Nathan Dunsmore, Zain Syed, Pauline Daley

Journal of Community Hospital Internal Medicine Perspectives

This is part of a series of case reports detailing scenarios from our community hospital. The cases are selected to feature clinical dilemmas, provide a review on what is currently known about the topic with expert perspective. A 66-year-old black man presented to the primary care clinic with his fourth episode of generalized painful rash and oral ulcerations without a diagnosis despite two emergency room (ED) visits alongside doxycycline treatment. Symptoms interfered with daily activities with skin exam notable for widespread erythematous patches and plaques. In office biopsies were obtained with final diagnosis of erythema multiforme. Etiologic workup revealed positive …


A Rare Presentation Of Erysipelothrix Rhusiopathiae Endocarditis With Acute Heart Failure, Maryam Barkhordarian, Mark Grijalva, James Liu, Muhammad Yasir, Abraham Lo Jan 2024

A Rare Presentation Of Erysipelothrix Rhusiopathiae Endocarditis With Acute Heart Failure, Maryam Barkhordarian, Mark Grijalva, James Liu, Muhammad Yasir, Abraham Lo

Journal of Community Hospital Internal Medicine Perspectives

Erysipelothrix rhusiopathiae is an occupation-related infection that can be found in farm animals or marine life. This infection can present with a spectrum of infection ranging from local cellulitis to aortic endocarditis. Developing endocarditis is rare from this organism with only a few case reports in the literature. We presented a case of Erysipelothrix rhusiopathiae bacteremia that led to aortic valve endocarditis with a Gerbode defect within the mitral valve complicated with an acute exacerbation of congestive heart failure, necessitating emergent valve replacement surgery, with eventual permanent pacemaker due to complete heart block. We intend to highlight some unusual characteristics …


Subacute Thyroiditis Due To Covid-19 Vaccine, Nishant Kumar, Dina Zeki, Mihail Zilbermint Jan 2024

Subacute Thyroiditis Due To Covid-19 Vaccine, Nishant Kumar, Dina Zeki, Mihail Zilbermint

Journal of Community Hospital Internal Medicine Perspectives

In this report, we present a case of a 90-year-old female who exhibited a sudden onset of confusion and severe generalized weakness after receiving her second dose of mRNA SARS-CoV-19 vaccination 19 days prior to her admission in 2021. Her thyroid-stimulating hormone (TSH) levels were low, while her thyroxine (T4), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were elevated. Triiodothyronine (T3) level was not measured. Ultrasonography of the thyroid revealed multiple nodules with heterogeneous tissue, and a nuclear medicine thyroid uptake scan showed very low uptake. These findings indicated limited thyroid destruction in the form of subacute thyroiditis, …


Pulmonary Embolism In A Patient With Rheumatoid Arthritis On Etanercept Therapy., Moni Roy, Himanshu Rathore, Ashish Kumar Roy Jan 2024

Pulmonary Embolism In A Patient With Rheumatoid Arthritis On Etanercept Therapy., Moni Roy, Himanshu Rathore, Ashish Kumar Roy

Journal of Community Hospital Internal Medicine Perspectives

Pulmonary embolism (PE) represents mechanical obstruction of one or more branches of pulmonary vasculature due to thromboembolism from a deep vein thrombosis. Hormonal contraceptives, hormonal replacement therapy, antipsychotics and fibrates are medications that are associated with increased risk of venous thromboembolism(VTE). Etanercept is a TNF alpha and beta receptor blocker. Rarely this medication has been identified as a risk factor for VTE. There is a possible correlation between rheumatoid arthritis(RA) and risk of VTE in patients with RA. Use of medication that can increase risk of VTE in a patient with systemic inflammatory condition that in itself may be a …


Reactive Arthritis After Mpox Vaccination, Indira Acharya, Lanaya Williams Smith, Chandralekha Banerjee, Lyn M. Camire, Radhika Vij Jan 2024

Reactive Arthritis After Mpox Vaccination, Indira Acharya, Lanaya Williams Smith, Chandralekha Banerjee, Lyn M. Camire, Radhika Vij

Journal of Community Hospital Internal Medicine Perspectives

Autoimmune inflammatory reaction after vaccination is a rare clinical entity. Reactive arthritis has been described after various vaccinations, but not after mpox vaccination. Here we present a case of recently diagnosed reactive arthritis after mpox vaccination that presented in the context of unrelenting fever and diarrhea complicated by migratory arthritis and anterior uveitis. We have reported this case to the Vaccine Adverse Event Reporting System (VAERS).


Pulmonary Clostridium Perfringens: Seeding Beyond The Gastrointestinal Tract, Thilini Delungahawatta, Shiavax J. Rao, Marcos Wolff, Christopher J Haas Jan 2024

Pulmonary Clostridium Perfringens: Seeding Beyond The Gastrointestinal Tract, Thilini Delungahawatta, Shiavax J. Rao, Marcos Wolff, Christopher J Haas

Journal of Community Hospital Internal Medicine Perspectives

Clostridia perfringens infection outside the gastrointestinal system is rare. Here, we report on a 75-year-old man with history of end-stage renal disease presenting after a syncopal event with lactic acidosis, leukocytosis, and mild hyperbilirubinemia. Chest imaging revealed a loculated, left-sided pleural effusion; diagnostic thoracentesis identified Clostridia perfringens, consistent with an empyema. Video-assisted thoracic left lung decortication was performed; tissue culture also speciated Clostridia perfringens. Further imaging revealed concomitant acute cholecystitis, suggesting hematogenous seeding or transdiaphragmatic extension of Clostridia perfringens to pleural space from an abdominal source. The patient was successfully managed with laparoscopic cholecystectomy and discharged on a one-month course …


A Stitch In Time Saves Nine: Planning For Artesunate Supply With Malaria On The Rise, Barath Prashanth Sivasubramanian, Viraj Panchal, Diviya Bharathi Ravikumar, Srikanth Puli, Aalok Khole, Gerard Kiernan, Vikramaditya Samala Venkata Jan 2024

A Stitch In Time Saves Nine: Planning For Artesunate Supply With Malaria On The Rise, Barath Prashanth Sivasubramanian, Viraj Panchal, Diviya Bharathi Ravikumar, Srikanth Puli, Aalok Khole, Gerard Kiernan, Vikramaditya Samala Venkata

Journal of Community Hospital Internal Medicine Perspectives

Background: Malaria is extremely rare in the United States. Physicians should not only be familiar with signs and symptoms, but also be aware of the available resources at their respective institutions to be able to effectively treat it. Presentation: 52-year-old female presented with worsening generalized fatigue. Vitals were stable. Labs were significant for anemia and thrombocytopenia. Peripheral smear showed ring formed parasitic trophozoites consistent with Plasmodium falciparum. Due to unavailability of antimalarial agents at our hospital, the patient was transferred to a tertiary care center. Patient was started on IV artesunate therapy. Repeat smear after 3 days showed


Compartmental Modeling For The Neophyte: An Application Of Berkeley Madonna, Olcay Akman, Siddharth Bhumpelli, Cody Cline, Christopher Hay-Jahans Jan 2024

Compartmental Modeling For The Neophyte: An Application Of Berkeley Madonna, Olcay Akman, Siddharth Bhumpelli, Cody Cline, Christopher Hay-Jahans

Spora: A Journal of Biomathematics

Compartmental modeling serves as a necessary framework in many fields, especially biomathematics and ecology. This article introduces readers to a user-friendly approach to constructing compartmental models and solving the resulting systems of differential equations to simulate real-world applications. The platform used is Berkeley Madonna, a software package that has an intuitive graphical interface which empowers users—even those with limited mathematical and programming backgrounds—to focus on modeling concepts rather than mathematical or programming intricacies. This makes Berkeley Madonna an ideal platform for students, educators, and researchers.


System And Method For Redeeming Issuer Reward Currency For A Consumer Benefit Supplement, Michelle Dollin, Raja Veeramani Jan 2024

System And Method For Redeeming Issuer Reward Currency For A Consumer Benefit Supplement, Michelle Dollin, Raja Veeramani

Defensive Publications Series

The present disclosure provides a method for redeeming issuer reward currency. Initially consumer books travel and logs into issuer application. The present disclosure calls Card Eligibility Service (CES) by sending cardholder travel information to check for eligible lounges. The CES pulls all lounges in airport and checks if cardholder is eligible for any of the lounges. The CES returns the cardholder list of lounges eligibility information and redemption limits and prices. The present disclosure offers to purchase additional guests for the lounge using points. The present disclosure calls CES and Pay with Points APIs to purchase additional guest access using …


Zinc And Bismuth Additives' Impacts On The Physical Properties Of Lead-Free Alloys Used In Electronic Appliances, Hesham Elzanaty, Rizk Mostafa Shalaby Jan 2024

Zinc And Bismuth Additives' Impacts On The Physical Properties Of Lead-Free Alloys Used In Electronic Appliances, Hesham Elzanaty, Rizk Mostafa Shalaby

Mansoura Engineering Journal

The goal of the current analysis was to analytically inspect how the addition of zinc and bismuth would alter the binary structure of the lead-free solder Sn-5Sb. Binary arrangement results have been stretched to the ternary arrangements Sn–5Sb–XBi or XZn (0 ≤ X ≤ 4wt.%) solder that were composed through rapid solidification processing (RSP) using the melt–spun method. The created phases were revealed through metallographic study of the formed alloys using XRD. High elastic modulus E = 32.5 GPa and good electrical resistivity = 26x10-8 .m are two characteristics of binary Sn-Sb doped with Bi. The alloy Sn–5Sb–4Zn owns the …


Microwell Assembly Method Using Inkjet Printing On Photopolymer, Hp Inc Jan 2024

Microwell Assembly Method Using Inkjet Printing On Photopolymer, Hp Inc

Defensive Publications Series

Patterned microwell structures are ubiquitous in many applications such as biochips, microfluidics, single-cell analysis, and patterning of various functional materials including optical and magnetic nanoparticles. Conventional microwell fabrication methods are based on laser etching and lithography, which provide high resolution at micro and nanometric scales. However, these methods are expensive, multistep, patterning rigidity and limited to small area fabrication. This disclosure describes a method to fabricate microwell structures using an inkjet printer and a light responsive material (photopolymer), wherein it is simple, inexpensive, prompt and requires no further cleaning prior use. In addition, the patterning of the microwells is no …


Mapping The Light Scattering Distribution In A Three-Phase Photopolymer Resin System To Predict Cured Dimensions, Darshil Shah, Joshua Morris, Alireza Amirkhizi, Christopher Hansen Jan 2024

Mapping The Light Scattering Distribution In A Three-Phase Photopolymer Resin System To Predict Cured Dimensions, Darshil Shah, Joshua Morris, Alireza Amirkhizi, Christopher Hansen

Innovative Materials & Methods for Additive Manufacturing II (IM²AM)

Please click Additional Files below to see the full abstract.


The Contribution Of Mindfulness Practice To Supporting Children And Their Families’ Challenges Among School Social Workers: A Qualitative Multicase Study Of School Social Workers In California, Catalina Andrade Jan 2024

The Contribution Of Mindfulness Practice To Supporting Children And Their Families’ Challenges Among School Social Workers: A Qualitative Multicase Study Of School Social Workers In California, Catalina Andrade

Dissertations

Purpose: The purpose of this qualitative multicase study was to describe the challenges school social workers experience when supporting students and their families in their schools. Additionally, the purpose of this study was to understand how school social workers use mindfulness practices to help them respond to the challenges of working with the students and their families in their school based on Lesser’s mindfulness model (2019): love the work, do the work, don’t be an expert, connect to your pain, connect to the pain of others, depend on others, and keep making it simpler. Methodology: In this multicase study, the …


Great Salt Lake Data And Insights Summary: A Synthesized Resource Document For The 2024 General Legislative Session, William Anderegg, Craig Buttars, Joel Ferry, Natalie Gochnour, Kim Shelley, Brian Steed, David G. Tarboton, Leila Ahmadi, Eric Albers, Blake Bingham, Paul D. Brooks, Tim Davis, Eric Dixon, Joanna Endter-Wada, Tage Flint, Candice Hasenyager, Timothy Hawkes, William Johnson, John Lin, John Mackey, Anna Mcentire, Bethany Neilson, Sarah Null, Kevin Perry, Ben Stireman, Courenay Strong, Laura Vernon, Marissa Weinberg, Matt Yost Jan 2024

Great Salt Lake Data And Insights Summary: A Synthesized Resource Document For The 2024 General Legislative Session, William Anderegg, Craig Buttars, Joel Ferry, Natalie Gochnour, Kim Shelley, Brian Steed, David G. Tarboton, Leila Ahmadi, Eric Albers, Blake Bingham, Paul D. Brooks, Tim Davis, Eric Dixon, Joanna Endter-Wada, Tage Flint, Candice Hasenyager, Timothy Hawkes, William Johnson, John Lin, John Mackey, Anna Mcentire, Bethany Neilson, Sarah Null, Kevin Perry, Ben Stireman, Courenay Strong, Laura Vernon, Marissa Weinberg, Matt Yost

Watershed Sciences Faculty Publications

In 2023, Great Salt Lake rose from the record-low elevation reached in 2022, aided by record-high winter snowfall and the adaptive management berm. Economic activity, public health, and the lake's ecosystems continue to be adversely impacted by low water levels. This summary synthesizes essential data and insights so decision-makers have the information they need to improve water management, increase water deliveries to the lake, mitigate adverse impacts, and recover the lake to a healthy range.


Improvement Of Convective Drying Equipment, A Ponasenko, Jasur Safarov, Shaxnoza Sultanova Jan 2024

Improvement Of Convective Drying Equipment, A Ponasenko, Jasur Safarov, Shaxnoza Sultanova

Technical science and innovation

Drying of agricultural raw materials is an energy-consuming but integral process. Therefore, increasing the efficiency of drying and improving the quality indicators of dried material at minimum material and energy costs is relevant for producers of agricultural products. By present time numerous researches on improvement of constructions and processes of work of dryers providing satisfactory parameters of energy saving have been carried out. In some scientific materials it is shown that the use of generative gas and straw as fuel allows to reduce energy costs for the drying process in the fluidised bed dryer by 10-30%, the quality of seeds …


Existing Methods For Monitoring Power Autotransformers, Nurali Berdiyorovich Pyrmatov, Dilafruz Rustamjon Qizi Abdullabekova Jan 2024

Existing Methods For Monitoring Power Autotransformers, Nurali Berdiyorovich Pyrmatov, Dilafruz Rustamjon Qizi Abdullabekova

Technical science and innovation

autotransformers, methods, diagnostics, efficiency, monitoring.Particular attention is given to analyzing the gas composition of transformer oil, which is a sensitive indicator of various defects such as thermal breakdown and heating. In addition, methods based on the measurement of external magnetic field strength are discussed. This technique provides a unique opportunity to detect magnetic anomalies associated with possible defects in the structural components of the transformer. The article emphasizes that successful monitoring requires an integrated approach, combining different techniques. The authors analyze the advantages and limitations of each method and offer practical recommendations for integrating these methods into maintenance systems. In …


Capacitive Electrode Based Moisture Measurement Converter Errors And How To Eliminate Them, Hamdam Jabborov, Temurbek Rashidov Jan 2024

Capacitive Electrode Based Moisture Measurement Converter Errors And How To Eliminate Them, Hamdam Jabborov, Temurbek Rashidov

Technical science and innovation

The article discusses the errors associated with the moisture measuring transducer that is based on the cylindrical electrode, along with their sources and calculation formulas for error elimination. The initial capacitance of the capacitive electrode humidity converter is dependent on its geometric parameters, such as the radii of the electrodes and their length. Accurate calculation of these geometric parameters enables the reduction of regular measurement errors in the input and switching circuit of the moisture converter to a minimum value, resulting in a significant increase in the informativeness and accuracy of the output signal. Consequently, some sources of measurement errors …


January 10, 2024 Greenmail, University Of Alabama At Birmingham Jan 2024

January 10, 2024 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.


Antibiotic-Induced Gut Dysbiosis Elicits Gut-Brain Axis Relevant Multi-Omic Signatures And Behavioral And Neuroendocrine Changes In A Nonhuman Primate Model, Shivdeep S. Hayer, Mackenzie Conrin, Jeffrey French, Andrew K. Benson, Sophie Alvarez, Kathryn Dempsey, Anne Fischer, Zahraa Wajih Alsafwani, William Gasper, Mallory J. Suhr Van Haute, Haley R. Hassenstab, Shayda Azadmanesh, Missy Briardy, Skyler Gerbers, Aliyah Jabenis, Jennifer L. Thompson, Jonathan B. Clayton Jan 2024

Antibiotic-Induced Gut Dysbiosis Elicits Gut-Brain Axis Relevant Multi-Omic Signatures And Behavioral And Neuroendocrine Changes In A Nonhuman Primate Model, Shivdeep S. Hayer, Mackenzie Conrin, Jeffrey French, Andrew K. Benson, Sophie Alvarez, Kathryn Dempsey, Anne Fischer, Zahraa Wajih Alsafwani, William Gasper, Mallory J. Suhr Van Haute, Haley R. Hassenstab, Shayda Azadmanesh, Missy Briardy, Skyler Gerbers, Aliyah Jabenis, Jennifer L. Thompson, Jonathan B. Clayton

Food for Health: Publications

Emerging evidence indicates that antibiotic-induced dysbiosis can play an etiological role in the pathogenesis of neuropsychiatric disorders. However, most of this evidence comes from rodent models. The objective of this study was to evaluate if antibiotic-induced gut dysbiosis can elicit changes in gut metabolites and behavior indicative of gut-brain axis disruption in common marmosets (Callithrix jacchus) – a nonhuman primate model often used to study sociability and stress. We were able to successfully induce dysbiosis in marmosets using a custom antibiotic cocktail (vancomycin, enrofloxacin and neomycin) administered orally for 28 days. This gut dysbiosis altered gut metabolite profiles, …


The Effect Of The Heart Failure Nurse Navigator On 30-Day Hospital Readmissions Of Older Adults, Mary Ann Leavitt Jan 2024

The Effect Of The Heart Failure Nurse Navigator On 30-Day Hospital Readmissions Of Older Adults, Mary Ann Leavitt

Dissertations

Across the US, 22% of Medicare patients hospitalized with a diagnosis of heart failure (HF) will be readmitted within 30-days of discharge. There is no one cost-effective process identified to help patients transition home and maintain their own selfcare. The aim of this study is to compare readmission rates, HF knowledge, self-care, and quality of life for patients who transition home from the hospital under the care of a Heart Failure Nurse Navigator (HFNN) with patients who receive usual care.

The HFNN is a home health RN with specialized training in HF care. The HFNN visited intervention group (IG) participants …


A Case Study Of The Implementation Of The New Clery Act Guidelines, Eunice Adigun Jan 2024

A Case Study Of The Implementation Of The New Clery Act Guidelines, Eunice Adigun

Theses and Dissertations

The Clery Act requires all higher education institutions participating in federal financial aid programs to keep and disclose campus crimes by submitting an Annual Security Report by October 1st of every year. In October 2020, the U.S. Department of Education replaced the 265-page Clery Act guidelines for administrators with a 13-page Appendix with specific changes to geographical locations to include in the report, eliminated the definition of crimes, and limited individuals designated as Campus Security Authority to those with direct responsibilities over student affairs. This case study examined how campus security officers implement the new Clery Act guidelines in crime …


Able Will Suffice Universal Design For Learning In Music Education, Tina Holmes-Davis Jan 2024

Able Will Suffice Universal Design For Learning In Music Education, Tina Holmes-Davis

ABLE Books

No abstract provided.


Henderson Named One Of The Most Influential People In Legal Education, James Owsley Boyd Jan 2024

Henderson Named One Of The Most Influential People In Legal Education, James Owsley Boyd

Keep Up With the Latest News from the Law School (blog)

Indiana University Maurer School of Law Professor Bill Henderson has once again been recognized as one of the most influential people in legal education, but he’s not the only one with ties to the Law School on this year’s list.

The National Jurist ranked Henderson #18 on its list. Kellye Testy, a 1991 alumna of the Law School and president and CEO of the Law School Admission Council, is ranked second.


Cambrian Trilobites From The Nounan Dolomite And Lower St. Charles Formation (Upper Marjuman To Lower Sunwaptan; Miaolingian To Furongian Series), Smithfield Canyon, Northern Utah, Frederick A. Sundberg, Hannah R. Cothren, Carol M. Dehler Jan 2024

Cambrian Trilobites From The Nounan Dolomite And Lower St. Charles Formation (Upper Marjuman To Lower Sunwaptan; Miaolingian To Furongian Series), Smithfield Canyon, Northern Utah, Frederick A. Sundberg, Hannah R. Cothren, Carol M. Dehler

Geosciences Faculty Publications

The trilobite faunas that occur with the Steptoean Positive Isotope Carbon Excursion (SPICE) at Smithfield Canyon, Utah, have been reported, but not illustrated. Given the importance of the SPICE at this section for international correlations, the trilobites from new collections from the upper Nounan Dolomite to lower St. Charles Formation at Smithfield Canyon are reported herein and integrated with the previously reported taxa. Trilobite assemblages indicate that the upper Cedaria to the Ellipsocephaloides biozones (Miaolingian Series, Guzhangian Stage to Furongian Series, Jiangshanian Stage) are present stratigraphically below or above the SPICE.

Some of the taxa reported herein may represent new …


Introducing The Digital Scholarship Lab, Rebecca Fitzsimmons, Rachel Scott Jan 2024

Introducing The Digital Scholarship Lab, Rebecca Fitzsimmons, Rachel Scott

Faculty and Staff Publications – Milner Library

Milner Library recently opened a Digital Scholarship Lab and invites the community to consider how it might inform their teaching and research. Developed with input from two interdisciplinary working groups, the lab provides a space, programming, and specialized software and equipment for those interested in applying digital methods to their research and learning. The speakers will highlight some of the capabilities of the lab and invite your questions about integrating the space into your instruction and research. The session will bring together scholars with an interest in learning more about and engaging in digital scholarship, extending the community of practice …


Medical Monitoring Working Group Focused Call Summaries, Mike Mcanulty Jan 2024

Medical Monitoring Working Group Focused Call Summaries, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Temporal Changes In The Surface Chemistry And Topography Of Reactive Ion Plasma-Treated Poly(Vinyl Alcohol) Alter Endothelialization Potential, Ryan A. Faase, Novella M. Keeling, Justin S. Plaut, Christian Leycam, Gabriela Acevedo Munares, Monica T. Hinds, Joe E. Baio, Patrick L. Jurney Jan 2024

Temporal Changes In The Surface Chemistry And Topography Of Reactive Ion Plasma-Treated Poly(Vinyl Alcohol) Alter Endothelialization Potential, Ryan A. Faase, Novella M. Keeling, Justin S. Plaut, Christian Leycam, Gabriela Acevedo Munares, Monica T. Hinds, Joe E. Baio, Patrick L. Jurney

Faculty Research, Scholarly, and Creative Activity

Synthetic small-diameter vascular grafts (<6 mm) are used in the treatment of cardiovascular diseases, including coronary artery disease, but fail much more readily than similar grafts made from autologous vascular tissue. A promising approach to improve the patency rates of synthetic vascular grafts is to promote the adhesion of endothelial cells to the luminal surface of the graft. In this study, we characterized the surface chemical and topographic changes imparted on poly(vinyl alcohol) (PVA), an emerging hydrogel vascular graft material, after exposure to various reactive ion plasma (RIP) surface treatments, how these changes dissipate after storage in a sealed environment at standard temperature and pressure, and the effect of these changes on the adhesion of endothelial colony-forming cells (ECFCs). We showed that RIP treatments including O2, N2, or Ar at two radiofrequency powers, 50 and 100 W, improved ECFC adhesion compared to untreated PVA and to different degrees for each RIP treatment, but that the topographic and chemical changes responsible for the increased cell affinity dissipate in samples treated and allowed to age for 230 days. We characterized the effect of aging on RIP-treated PVA using an assay to quantify ECFCs on RIP-treated PVA 48 h after seeding, atomic force microscopy to probe surface topography, scanning electron microscopy to visualize surface modifications, and X-ray photoelectron spectroscopy to investigate surface chemistry. Our results show that after treatment at higher RF powers, the surface exhibits increased roughness and greater levels of charged nitrogen species across all precursor gases and that these surface modifications are beneficial for the attachment of ECFCs. This study is important for our understanding of the stability of surface modifications used to promote the adhesion of vascular cells such as ECFCs.


Development Of A Xenograft For Annular Repair Using Pulsed Electric Field Exposures For Enhanced Decellularization, Prince Mensah Kwaku Atsu Jan 2024

Development Of A Xenograft For Annular Repair Using Pulsed Electric Field Exposures For Enhanced Decellularization, Prince Mensah Kwaku Atsu

Theses and Dissertations

Severe back injuries and chronic pain necessitate surgical replacement of damaged intervertebral disc (IVD) cartilage in advanced disease stages. Bovine IVD tissue has been exposed to an upper threshold pulsed electric field (PEF) dose, causing cell death without thermal damage to the tissue. Subsequent PEF exposures at lower magnitudes have accelerated the removal of immunogenic biomolecules though electrokinetic extraction using optimized aqueous solutions. This approach yields a natural scaffold, ready for biocompatibility and mechanical strength assessment. The effects of microsecond pulsed electric fields (µsPEF) on primary bovine AF fibroblast-like cells have been characterized in vitro. PEFs of 10 and 100 …


Integrated Computer-Aided Design, Experimentation, And Optimization Approach For Perovskites And Petroleum Packaging Processes, Swapana Subbarao Jerpoth Jan 2024

Integrated Computer-Aided Design, Experimentation, And Optimization Approach For Perovskites And Petroleum Packaging Processes, Swapana Subbarao Jerpoth

Theses and Dissertations

According to the World Economic Forum report, the U.S. currently has an energy efficiency of just 30%, thus illustrating the potential scope and need for efficiency enhancement and waste minimization. In the U.S. energy sector, petroleum and solar energy are the two key pillars that have the potential to create research opportunities for transition to a cleaner, greener, and sustainable future. In this research endeavor, the focus is on two pivotal areas: (i) Computer-aided perovskite solar cell synthesis; and (ii) Optimization of flow processes through multiproduct petroleum pipelines. In the area of perovskite synthesis, the emphasis is on the enhancement …