Digital Commons Network^™

Acetylcholine Receptor Based Chemogenetics Engineered For Neuronal Inhibition And Seizure Control Assessed In Mice, Quynh-Anh Nguyen, Peter M Klein, Cheng Xie, Katelyn N Benthall, Jillian Iafrati, Jesslyn Homidan, Jacob T Bendor, Barna Dudok, Jordan S Farrell, Tilo Gschwind, Charlotte L Porter, Annahita Keravala, G Steven Dodson, Ivan Soltesz

Faculty, Staff and Students Publications

Epilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient outcomes. Chemogenetic approaches, where exogenous receptors are expressed in defined brain areas and specifically activated by selective agonists, are appealing methods to constrain overactive neuronal activity. We developed BARNI (Bradanicline- and Acetylcholine-activated Receptor for Neuronal Inhibition), an engineered channel comprised of the α7 nicotinic acetylcholine receptor ligand-binding domain coupled to an α1 glycine receptor anion pore domain. Here we demonstrate that BARNI activation by the clinical stage α7 nicotinic acetylcholine receptor-selective agonist bradanicline effectively suppressed targeted neuronal activity, and controlled both …

January 18, 2024, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Evaluation Of Seven Satellite-Based And Two Reanalysis Global Terrestrial Evapotranspiration Products, Zijing Xie, Yunjun Yao, Qingxin Tang, Meng Liu, Joshua B. Fisher, Jiquan Chen, Xiaotong Zhang, Kun Jia, Yufu Li, Ke Shang, Bo Jiang, Junming Yang, Ruiyang Yu, Xueyi Zhang, Xiaozheng Guo, Lu Liu, Jing Ning, Jiahui Fan, Lilin Zhang

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Although comprehensive evaluation of different types of global terrestrial evapotranspiration (ET) products has been conducted, the satellite remote sensing techniques have prompted the development of several available global ET products, warranting a reassessment as products continue to evolve. Recently, we produced the long-term Global LAnd Surface Satellite (GLASS) ET product, but there is a lack of comparison and evaluation with other ET products and EC observations on a global scale. In this study, we evaluated the accuracy and uncertainty of seven satellite-based (GLASS-AVHRR, GLASS-MODIS, BESS, FLUXCOM, GLEAM, MOD16, and PML_V2) and two reanalysis (ERA5 and MERRA2) global terrestrial ET products …

Beyond Teaching: The Self-Fulfillment Of Creating A Positive And Safe Learning Environment For Children Exposed To Aces, Tessa J. Davis

The Journal of Advancing Education Practice

Due to factors such as burnout, lack of support, heavy workload, and student behavior, teachers are exiting the field for other occupations. Retention has become an issue. However, teachers are finding a sense of value and self-fulfillment for the same reasons they are leaving, which restores their outlook. This opinion paper will focus on teachers finding value in creating a positive learning environment in the classroom and creating resilience for students exposed to adverse childhood experiences at home.

Vol. 60 No. 4 - Whole No. 407, Megan Abrahamson

Mythprint

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

Booklet Of Sermon Notes For 1942-1943, Earl Clement Davis

Sermons, 1933-1953

For the years 1938 through 1947 Davis collected his sermon notes in more-or-less annual hand-bound booklets. This Booklet contained sermons for two years, 1942 and 1943, 101 different sermon notes in total.

The transcription of these notes have been separated into two shorter—although still long—documents, the first with the notes for sermons given during 1942 and the second for notes given during 1943. The primary document available for download is the full scan of the booklet itself. Supplemental downloads include the two transcription files, and the two sermon list documents for 1942 and 1943, respectively.

Transcription by Davis Baird. Item …

Studying Adherence To Reporting Standards In Kinesiology: A Post-Publication Peer Review Brief Report, Nikki M. Watson, Jafra D. Thomas

International Journal of Exercise Science

International Journal of Exercise Science 17(7): 25-37, 2024. To demonstrate how post-publication peer reviews—using journal article reporting standards—could improve the design and write-up of kinesiology research, the authors performed a post-publication peer review on one systematic literature review published in 2020. Two raters (1^st & 2^nd authors) critically appraised the case article between April and May 2021. The latest Journal Article Reporting Standards by the American Psychological Association relevant to the review were used: i.e., Table 1 (quantitative research standards) and Table 9 (research synthesis standards). A standard fully met was deemed satisfactory. Per Krippendorff’s alpha-coefficient, inter-rater agreement …

Effects Of Supramaximal Anderson Quarter-Squats As A Potentiating Stimulus On Discus Performance In Division I Throwers: A Pilot Study, Ogochukwu I. Nwachukwu, Mark Debeliso Phd, Marcus M. Lawrence Phd

International Journal of Exercise Science

International Journal of Exercise Science 17(6): 99-114, 2024. No study has assessed supramaximal (over 100% 1RM) back squat variations as a potentiating stimulus in collegiate throwers. The purpose of this study was to test the hypothesis that a supramaximal Anderson (bottom-up) quarter squat potentiating stimulus would improve discus throw performance in Division I throwers compared to a dynamic warm-up alone. Nine NCAA division I thrower athletes (age: 20.1±1.4 years; 1RM back squat/body weight: 2.5±0.4 kg) randomly completed two sessions separated by at least 72 hours. One session involved a standardized dynamic warm-up alone (DyWU) followed by three trials of maximal …

Fat-Free Mass Index In A Large Sample Of Collegiate American Football Athletes, Jennifer B. Fields, Margaret T. Jones, Adam Feit, Meghan K. Magee, Nicholas M. Kuhlman, Andrew R. Jagim

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 129-139, 2024. High levels of fat-free mass (FFM) are favorable for athletes and are related to sport performance. However, fat-free mass index (FFMI), which includes adjustments for height, may offer a better way to characterize FFM beyond raw values. As FFMI is understudied relative to sport, the purpose of the current study was to assess position and age group differences in FFMI among collegiate American football players. National Collegiate Athletic Association DIII (n=111) football players underwent body composition assessment via bioelectrical impedance analysis. FFMI was calculated by dividing FFM by height squared. One-way analyses …

Lower-Body Strength Relationships With Sprint, Jump, And Sport-Specific Skill Performance In High School Girls Softball Players, Robert G. Lockie, Jacob D. Patron, J. Jay Dawes, Erika Viramontes

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 86-98, 2024. Softball athletes require multiple fitness traits (e.g., strength, speed, power) and sport-specific skills (e.g., hitting, throwing) for success. Lower-body strength could underpin these qualities; this has received little analysis among high school female athletes. This research investigated correlations between absolute and relative lower-body strength with age, linear speed, lower-body power, and throwing and hitting velocity in high school girls softball athletes. Archival data collected from 34 high school girls softball players (age=14.91±1.00 years; height=1.66±0.07 m; body mass=63.21±9.59 kg) from a private strength and conditioning facility was analyzed. The data included: age, height, …

Physical Fitness Responses After Sixteen Weeks Of Three Fitness Program Trainings In Untrained Subjects, Habil Hamdouni, Brian Kliszczewicz, Hassane Zouhal, Abderraouf Ben Abderrahman

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 54 - 72, 2024. The remarkable popularity of fitness trends like high intensity functional training (HIFT), choreographed high intensity classes (CHIC) and resistance (RT) trainings raises the question on their effect on cardio-respiratory, lactate removal rate, endurance and body composition responses. The purpose of this study was to assess and compare these effects. Ninety-five participants were randomly assigned into 16 weeks of these trainings, five sessions/week. Anthropometric and fitness tests were carried out before training (PRE), after eight (8W) and sixteen weeks (16W). Body composition measures demonstrated significant decrease in body fat percentage ( …

More Than Body Composition: A Darwinian Theory Of Somatotype, Applied To A Dii Track And Field Outdoor Season, Whitley J. Stone, Matthew J. Garver, Amanda Wakeman, Danilo Tolusso, Hannah Nelson, Josie Hair, Eric Nehlsen

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 1-12, 2024. This study presents somatotype data on a team sport with chronic and diverse sporting demands. The aims were to (1) characterize a somatotype profile for Division II (DII) track and field athletes (n=54) by sex, class, and events; (2) determine if somatotype changed across the season; (3) determine if changes differed based on class or sex; and, (4) assess potential differences in somatotype between sexes. Methods: Anthropometrics (height, weight, body composition, somatotype) were evaluated after a competitive indoor season and immediately before the outdoor conference championships (41 days). Body measurements were assessed …

Feasibility Of Blood Flow Restriction Exercise In Adults With A Non-Surgically Treated Achilles Tendon Rupture; A Case Series, Andreas Bentzen, Stian Langgård Jørgensen, Sara Birch, Louise Mortensen, Marianne Toft, Michael Godsvig Lindvig, Per Hviid Gundtoft, Inger Mechlenburg

International Journal of Exercise Science

International Journal of Exercise Science 17(3): 140-153, 2024. Blood flow restriction exercise (BFRE) appears to provide a unique opportunity to preserve lower limb muscle and function in patients with an Achilles tendon rupture. The purpose of this study was to investigate the feasibility of BFRE in patients with an Achilles tendon rupture. Additionally, to evaluate muscle volume and patient-reported ankle function, symptoms, complications, and physical activity following 12 weeks of BFRE. Feasibility was measured by adherence to training sessions, drop-out rate, intervention acceptability, ankle pain exacerbation (NRS), and adverse events. At baseline and 12-weeks follow-up, patients completed the Achilles Tendon …

Evaluation Of The Craniovertebral Angle In Standing Versus Sitting Positions In Young Adults With And Without Severe Forward Head Posture, David A. Titcomb, Bridget F. Melton, Helen W. Bland, Theresa Miyashita

International Journal of Exercise Science

International Journal of Exercise Science 17(1): 73-85, 2024. The purpose of this study was to examine the effects of standing versus sitting body position on the craniovertebral angle (CVA) in young adults without pathology; and to investigate whether mean differences between positional CVA measures in subjects with severe forward head posture (FHP) are distinct from age-matched controls with normal head posture. Ninety-eight young adults (68 women, 30 men) without pathology (OVERALL; n = 98) volunteered for the study; those with CVA > 53° were also included in a normal posture group (NORM; n = 14); those with CVA < 45° were also included in a severe FHP group (SEV; n = 15). …

Bench Press Range-Of-Motion And Velocity-Based Repetition Control: Effects On Ballistic Push-Up Performance In Males, Kyle Collins, Adam Bradley, Bryan Christensen, Roman Waldera, Lukus Klawitter, Liam Ogren, Robert Salatto

International Journal of Exercise Science

International Journal of Exercise Science 17(1): 38-53, 2024. The purpose of this study was to investigate whether the ballistic push-up (BPU) is responsive to post-activation performance enhancement (PAPE) after a bench press conditioning exercise using velocity-based repetition control. Additionally, we aimed to evaluate the effects of range of motion (ROM) conditions on subsequent BPU performance. In a randomized crossover design, 18 males performed two conditions (full ROM and self-selected partial ROM) of bench press at 80% of their 1RM until mean concentric velocity dropped 10%. Each participant performed two pre- and six post-test BPUs to assess the PAPE effect. Paired …

Sleep Duration As A Risk Factor For Suicide Ideation And Attempts In Minoritized Youth, Danielle Williams

Posters-at-the-Capitol

Sleep duration as a risk factor for suicide ideation and attempts in minoritized youth

Danielle L. Williams, Caitlin P. Gregory, B.S., Jenessa Canen, B.S., & Amy Brausch Ph.D.

Background and Objective: Suicide is the second leading cause of death in the United States for adolescents and poor sleep is a significant risk factor for suicide ideation and attempts. However, research shows that suicide risk factors identified in predominantly white samples of youth do not have the same association for racial minority youth; sleep may be one such factor. The current study evaluated how the association of total sleep duration with …

Predicting The Reactions Of Cs2, Ocs, And Co2 With Group Iv And Group Vi Transition Metal Oxides, Marissa Shea Blair, Zachary Ryan Lee Phd, David A. Dixon Phd

Posters-at-the-Capitol

Building on a recent serious of high level electronic structure studies of Lewis acid gas reactions with metal oxide sorbents, DFT (B3LYP and ωB97X-D) and CCSD(T) methods are being used to predict the Lewis acid-base addition (physisorption) and formation of metal oxide carbonate/thiocarbonate formation (chemisorption) reactions of CS2, OCS, and CO2 of CS2, OCS, and CO2 with Group IV (MO2)n and Group VI (MO3)n (n = 1 - 3) nanoclusters. For the Group IV oxides, chemisorption to form terminal carbonates and thiocarbonates is predicted to be the most favored, with thiocarbonate ligand binding energies slightly more exothermic than their carbonate …

The Effects Of Liftng Belts On Power Output, Julio Aguilar, Benjamin Coldwell, Patrick Jackson, Cade Pippen, Zane Thornton

International Journal of Exercise Science: Conference Proceedings

JULIO AGUILAR, BENJAMIN COLDWELL, PATRICK JACKSON, CADE PIPPEN, ZANE THORTON.

Kinesiology & Health Science; Stephen F. Austin State University; Nacogdoches, TX

Category: Undergraduate

Advisor: Chelette, Amber, [email protected]

Lifting belts, when lifting heavy weights, are purportedly used to support, stabilize, and attenuate the load on the spine. With the additional support, potential questions arise about whether weightlifting belts affect the power performed when squatting. This study aimed to examine the power produced during a squat with a weightlifting belt compared to a squat performed without one. Ten subjects, five male and five female, performed squats of two sets of 3 repetitions, …

Perceived Outcomes Of Periacetabular Osteotomy, Ryan Bialaszewski, John M. Gaddis, Bretton Laboret, Joel Wells, Adina Stewart

Research Symposium

Aims: Social media is a popular resource for patients seeking medical information and sharing experiences. periacetabular osteotomy (PAO) is the gold-standard treatment for symptomatic acetabular dysplasia with good long-term outcomes. However, little is known regarding the perceived outcomes of PAO on social media. The aims of this study were to describe the perceived outcomes following PAO using three social media platforms: Facebook, Instagram, and X (formerly known as Twitter).

Methods: Facebook, Instagram, and X posts were retrospectively collected from 1 February 2023. Facebook posts were collected from the two most populated interest groups: “periacetabular osteotomy” and “PAO Australia.” Instagram and …

Signs Of Rheumatoid Arthritis With Negative Serum Markers: A Diagnostic Challenge, Prakhar Jain, Chelsea Chang, Jessica Marcela Daza

Research Symposium

Background: Rheumatoid arthritis affects 1.3 million adults in US and can be challenging to diagnose. Clinicians need to develop a good sense of pretest probability, or likelihood of this disease, before initiating testing. This case explores the association between palmar erythema, rheumatoid arthritis, the differential diagnoses and testing available.

Case presentation: This case involves a 55 year old woman with no past medical history who is presenting to the clinic with a 1 year duration of 7 out of 10 throbbing pain of the bilateral palms. There is no arthralgia. The pain worsens with activities that involve the hands and …

Effective Management And Implementation Of A Coordinated Health Program - The Steps Snap-Ed Experience, Moises Cisneros, Brenda Rodriguez-Guerra, Joseph Reyes, Emilio Puente Barrios

Research Symposium

Purpose: Coordinated health programs have been proposed for more than four decades to improve the health of children in school settings. Although a challenging task, it has the potential to touch many lives, especially those from impoverished communities (Darlington, Violon, & Jourdan, 2018). The South Texas Early Prevention Studies (STEPS) aim to positively impact the community of the Rio Grande Valley, a population known to have a high rate of obesity, by implementing a comprehensive and proactive approach with various components within a preschool students’ life. The project's goal has been to plant a seed at an early age for …

Submental Intubation In Oral Maxillofacial Surgery: A Case Report And Review Of Indications And Complications, Jennifer Inofomoh, Mark Lavering, Ed Wong Alvarado, Diego Aleman

Research Symposium

Introduction/ Background: Submental intubation is a valuable alternative airway management technique employed in oral maxillofacial surgery when intraoral or nasal intubation is contraindicated or poses a potential risk (Schütz, 2008). This case report presents a clinical scenario in which a patient underwent oral maxillofacial surgery necessitating submental intubation. Additionally, we review the indications, technique, and potential complications associated with this specialized intubation approach.

Oral maxillofacial surgeries frequently involve complex fractures, extensive soft tissue injuries, or anatomical variations that preclude traditional intraoral or nasal intubation. Submental intubation provides a safe and effective option in such cases, avoiding the need for tracheostomy …

Treatment Strategies For Metabolic Associated Fatty Liver Disease (Mafld) In Childhood: A Systematic Review, Anthony Alanis, Alisha Valdez, Hector Rivera-Marrero, Joshua Membreno, Isabel Omaña-Guzman, Marisol Rosas-Diaz, Yoscelina Estrella Martínez-López, Esperanza Milagros Garcia-Oropesa, Nayely Garibay-Nieto, Alejandra Bustamante, Octelina Castillo-Ruiz, Beatriz Tapia, Leonel Vela, Kathleen V. Carter, Juan Carlos Lopez-Alvarenga

Research Symposium

Introduction: Obesity is associated with various metabolic conditions, but the impact differs between children and adults. Our previous research has demonstrated that children may exhibit reversibility in biochemical features, while experiencing less response in terms of anatomical damage. Metabolic Associated Fatty Liver Disease (MAFLD) is a condition that necessitates urgent treatment during childhood to mitigate future complications, such as worsening chronic inflammation and increased predisposition to diabetes, hypertension, or endothelial damage. In this study, we aim to evaluate the main clinical interventions (including drugs, behavioral treatments, nutrition programs, and traditional medicine) that effectively reduce MAFLD in children with obesity. …

Alcoholism And Psychiatric Comorbidity: A Complex Relationship, Aniket Saini, Pooja Chawla

Research Symposium

Alcoholism, also known as alcohol use disorder (AUD), is a chronic and relapsing condition characterized by the excessive and compulsive consumption of alcohol which leads to negative effects on the physical as well as mental health. Heavy drinking associated with alcoholism can coexist with or contribute to several different psychiatric disorders like depression, bipolar disorder, anxiety disorder, antisocial personality disorder, and schizophrenia. In patients with AUD, around 80% of cases suffer from a social anxiety disorder, 27% -40% of cases are diagnosed with major depressive disorder, 19%-26% of young adults suffer from attention-deficient hyperactivity disorder, 21% of patients with AUD …

Communication And Cultural Strategies Impacting Ukrainian Refugees And Others Involved, Kimberley Barker, David A. Victor, Christine R. Day

Global Advances in Business Communication

The Russian armed forces moved into Ukraine on February 24, 2022. Immediately and in the months following, millions of Ukrainians left their homes to seek a safe haven elsewhere. The dimensions of the Ukrainian refugee crisis are, in the words of Germany’s representative to the United Nations High Commission on Refugees (UNHCR) Katherina Lumpp, “unprecedented… the refugee movement we are now seeing in Ukraine is unique. It is currently the second largest refugee[1] situation in the world. No situation has developed this rapidly since the Second World War” (Bauer, 2022). As of October 2023, the UN Refugee Agency has …

Assessing The Impact Of Sustainable Recycled Concrete Aggregate On The Mechanical Properties Of Hot Mix Asphalt Mixtures, Tameem Mohammed Hashim

Al-Mustaqbal Journal of Sustainability in Engineering Sciences

The utilization of recycled materials in asphalt mixtures has gained significant attention in recent years due to environmental and economic considerations. This study aims to assess the impact of recycled concrete aggregate (RCA) on the mechanical properties of hot mix asphalt (HMA) mixtures. The mechanical properties examined include Marshall stability, air voids, and flow. A comprehensive laboratory investigation was conducted, involving the preparation and testing of HMA specimens with four proportions of RCA (0%, 20%, 40%, and 60%). The results indicated that incorporating RCA into HMA mixtures had a noticeable effect on the mechanical properties. As the proportion of recycled …

Features Of Monthly Precipitation Data Over Iraq Obtained By Trmm Satellite For Sustainability Purposes, Riyadh Abdul Abbas Ali Al-Sultani, Zahra Salahaldain, Sepanta Naimi

Al-Mustaqbal Journal of Sustainability in Engineering Sciences

To achieve the goals of sustainability, hydrological studies require analysis and modeling of precipitation data, in an accurate and reliable manner. However, measurements of precipitation ought to be more accurate representations of the actual distribution of precipitation. The methods and methods used to gather data on precipitation are numerous. With the advent of satellite products, namely, the Tropical Rainfall Measuring Mission (TRMM) precipitation, which can be used to estimate and analyze precipitation data, hydro-meteorological and climatological applications of satellite precipitation products have recently seen a significant improvement. In this study, the Iraqi Meteorological and Seismology Organization (IMSO) gathered ground-based rain …

Investigate The Effect Of Temperature Change On The Properties Of The Pp/Caco3 Composites: A Comparative Study, Nawar S. Bakly, Nabeel H. Al-Mutairi, Ali A. Layla, Mohammed Hamzah Almaamori

Al-Mustaqbal Journal of Sustainability in Engineering Sciences

In this paper, the effect of different temperatures (60 °C and 5 °C) between winter and summer in Iraq on the properties of PP that was filled with CaCO3 particles has been studied. The effects of CaCO3 particles with different percentages (8 wt.%, 16 wt.%, and 24 wt.%) on the mechanical, thermal, and rheological properties have been investigated. A twin-screw extruder was used for the preparation of the composite PP/ CaCO3. Mechanical properties such as tensile strength, elastic modulus, elongation at break, and impact strength were studied. Both Differential Scanning Calorimetry (DSC) and Fourier transform infrared (FTIR) were used to …

High-Fidelity 3d Hair Modeling Using Computed Tomography

Defensive Publications Series

An automatic framework for creating high-fidelity 3D hair models that are suitable for use in downstream graphics applications. This approach utilizes real-world hair wigs as input, and is able to reconstruct hair strands for a wide range of hair styles. Systems and method leverage computed tomography (Cl) to create density volumes of the hair regions, allowing users to see through the hair unlike image-based approaches which are limited to reconstructing the visible surface. To address the noise and limited resolution of the input density volumes, we employ a coarse-to-fine approach. This process first recovers guide strands with estimated 3D orientation …

The Role Of Storytelling In Advertising Design To Enhance The Brand, Eman Gibrel Ahmed Mohamed, Nagwa Yehia El Adawy, Samar Hany Abu Donia

Journal of Art, Design and Music

Storytelling has been a part of human civilization for thousands of years. It is used to send messages and share knowledge. Storytelling is a powerful communication tool that differentiates brands from others. It brings brands to life and gives them personality. As social media has become a vital part of individual's daily life, it provides companies with the ability to promote their products and services. Video advertisements are a type of visual storytelling that can attract and engage recipients. The aim of this research is to clarify the concept of storytelling, the structure and tools that storytellers use to create …