Digital Commons Network^™

Distinct Interactions Stabilize Egfr Dimers And Higher-Order Oligomers In Cell Membranes, Krishna C. Mudumbi, Eric A. Burns, David J. Schodt, Zaritza O. Petrova, Anatoly Kiyatkin, Lucy W. Kim, Emma M. Mangiacapre, Irais Ortiz-Caraveo, Hector Rivera Ortiz, Chun Hu, Kumar D. Ashtekar, Keith A. Lidke, Diane S. Lidke, Mark A. Lemmon

Pathology Research and Scholarship

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase with important roles in many cellular processes as well as in cancer and other diseases. EGF binding promotes EGFR dimerization and autophosphorylation through interactions that are well understood structurally. How these dimers relate to higher-order EGFR oligomers seen in cell membranes, however, remains unclear. Here, we used single-particle tracking (SPT) and Förster resonance energy transfer imaging to examine how each domain of EGFR contributes to receptor oligomerization and the rate of receptor diffusion in the cell membrane. Although the extracellular region of EGFR is sufficient to drive receptor dimerization, …

Acculturation And Intimate Partner Violence Among Kenyans In The United States, Max J. Stein, Peter Ndiang’Ui, Eunice Menja

Journal of Social, Behavioral, and Health Sciences

Intimate partner violence (IPV) is abuse by a partner or spouse. This study focused on IPV among Kenyan immigrants to the United States. Several studies reported connections between IPV and cultural tensions experienced during the acculturation process. Scholars disagree whether acculturation buffers against IPV by exposing immigrants to adaptive social norms or heightens risk factors among those facing challenges acclimating to new settings. Whereas this association has been researched among Latinx and Asian communities in the United States, it is understudied among African and especially Kenyan diasporas. This descriptive study explored how acculturation and IPV among U.S. Kenyans were experienced …

Synergistic Protection Of Retinal Ganglion Cells (Rgcs) By Sarm1 Inactivation With Cntf In A Rodent Model Of Nonarteritic Anterior Ischemic Optic Neuropathy, Yan Guo, Zara Mehrabian, Jeffrey Milbrandt, Aaron Diantonio, Steven L Bernstein

2020-Current year OA Pubs

We evaluated whether inhibiting sterile alpha and (Toll/interleukin receptor (TIR)) motif-containing 1 (SARM1) activity protects retinal ganglion cells (RGCs) following ischemic axonopathy (rodent nonarteritic anterior ischemic optic neuropathy: rNAION) by itself and combined with ciliary neurotrophic factor (CNTF). Genetically modified SARM1(-) rats were rNAION-induced in one eye and compared against equivalently induced wild-type animals of the same background. Optic nerve (ON) diameters were quantified using optical coherence tomography (SD-OCT). RGCs were quantified 30 d post-induction using retinal stereology for Brn3a(+) nuclei. ON sections were analyzed by TEM and immunohistochemistry. SARM1(-)(-) and WT animals were then bilaterally sequentially rNAION-induced. One eye …

In Search Of The Armorial Aesthetic: The Counter-Reform Of Ariano Suassuna And The Compositional Techniques In Clovis Pereira’S Suite Macambira, Wagner De Oliveira Duarte

LSU Doctoral Dissertations

Throughout the first half of the twentieth century, in the wake of the Week of Modern Art in São Paulo in 1922, Brazil grappled with defining its national identity, distinct from European influences. While eminent figures such as Villa-Lobos, Camargo Guarnieri, and Francisco Mignone provided foundational narratives in this quest, the Armorial movement emerged as a unique and emblematic response to these nationalistic aspirations.

Originating from the creative vision of Ariano Suassuna, the Armorial movement, though often perceived as a regional initiative, epitomized a broader endeavor to represent Brazil's diverse cultural tapestry. Central to understanding this movement is the work …

Application Of Learning Processes For Improving Last-Mile Logistics Optimization At Scale, Seyedeh Shaghayegh Rabbanian

LSU Doctoral Dissertations

The escalating demands of omnichannel retailing, rapid urbanization and shifting customer behaviors have propelled last-mile vehicle routing logistics to the forefront of research. This last-mile phase, recognized as a significant contributor to costs and pollution in the supply chain, necessitates efficient route optimization to minimize expenses and environmental impact. This research delves into machine learning based techniques for solving large-scale Vehicle Routing Problem (VRP), a fundamental concern in last-mile logistics, aiming to optimize delivery vehicle routing amidst diverse customer nodes and operational constraints. Three primary research subproblems are analyzed: utilizing machine learning for constructive solutions, Variable Neighborhood Search (VNS) metaheuristic, …

Intratumoral Biosynthesis Of Gold Nanoclusters By Pancreatic Cancer To Overcome Delivery Barriers To Radiosensitization, Aaron S Schwartz-Duval, Yuri Mackeyev, Iqbal Mahmud, Philip L Lorenzi, Mihai Gagea, Konstantin V Sokolov

Faculty, Staff and Student Publications

Nanoparticle delivery to solid tumors is a prime challenge in nanomedicine. Here, we approach this challenge through the lens of biogeochemistry, the field that studies the flow of chemical elements within ecosystems as manipulated by living cellular organisms and their environments. We leverage biogeochemistry concepts related to gold cycling against pancreatic cancer, considering mammalian organisms as drivers for gold nanoparticle biosynthesis. Sequestration of gold nanoparticles within tumors has been demonstrated as an effective strategy to enhance radiotherapy; however, the desmoplasia of pancreatic cancer impedes nanoparticle delivery. Our strategy overcomes this barrier by applying an atomic-scale agent, ionic gold, for intratumoral …

Multidisciplinary Prehabilitation To Improve Frailty And Functional Capacity In High-Risk Elective Surgical Patients: A Retrospective Pilot Study, Henry Man Kin Wong, Ding Qi, Bosco Hon Ming Ma, Pik Yi Hou, Calvin Ka Woon Kwong, Prehab Study Group

Faculty, Staff and Student Publications

BACKGROUND: Frailty is associated with worse outcomes and higher healthcare costs. The long waiting time for surgery is a potential 'teachable' moment. We examined the feasibility and safety of a pilot prehabilitation programme on high-risk frail patients undergoing major elective surgery.

METHODS: A single-centre, retrospective pilot study (Dec 2020-Nov 2021) on a one-stop prehabilitation programme (structured exercise training, nutritional counselling/therapy, and psychological support) in collaboration with geriatricians and allied health professionals. At least 4 weeks before surgery, patients at high risk of frailty or malnutrition, or undergoing major hepatectomy, esophagectomy, pancreaticoduodenectomy, or radical cystectomy, were referred for prehabilitation (2-3 sessions/week). …

Intratumoral Biosynthesis Of Gold Nanoclusters By Pancreatic Cancer To Overcome Delivery Barriers To Radiosensitization, Mihai Gagea

Faculty, Staff and Student Publications

Nanoparticle delivery to solid tumors is a prime challenge in nanomedicine. Here, we approach this challenge through the lens of biogeochemistry, the field that studies the flow of chemical elements within ecosystems as manipulated by living cellular organisms and their environments. We leverage biogeochemistry concepts related to gold cycling against pancreatic cancer, considering mammalian organisms as drivers for gold nanoparticle biosynthesis. Sequestration of gold nanoparticles within tumors has been demonstrated as an effective strategy to enhance radiotherapy; however, the desmoplasia of pancreatic cancer impedes nanoparticle delivery. Our strategy overcomes this barrier by applying an atomic-scale agent, ionic gold, for intratumoral …

Enhanced Scannable Info Page For Quick Settings, Hp Inc

Defensive Publications Series

A general trend among Internet-of-Things (IoT) devices is the bifurcation between 2 forms of walk-up user interfaces. The vast majority would be highly simplified (with indicator lights and buttons), while premium devices provide for increasingly large touchscreen controls. The choice of the majority is possible due to the ability of mobile computing devices such as Smartphones, to host apps that serve as a full-featured user interface, not just for 1 device, but for an entire device family. This enables significant cost savings at the device portfolio level, while enhancing usability.

Mechanical Stress Testing Of Data Center Hardware And Electronics Equipment, N/A

Defensive Publications Series

This disclosure describes techniques to perform random vibration testing of data center hardware and electronics equipment such as PCBA, machines, switches, and server racks. A shaker table is utilized to simulate multiple test profiles that are defined based on an analysis of a variety of field conditions and measured data from vehicles and handling methods common in the global supply chain. The test setup includes a shaker table, in addition to a vibration data acquisition and analysis system, a high speed power supply and resistance measurement system, and strain data acquisition system using a general purpose data acquisition unit designed …

Impact Of Type Of K Fertilizer On Dcad Of Fen Grassland In Northeast Germany, A. Behrendt, J. Pickert, F. Eulenstein, B. Kroschewski

IGC Proceedings (1977-2023)

A lower DCAD is required in the diet fed during the prepartum period, but increasing the DCAD of diets fed during lactation increased milk yield and dry matter intake (Overton 2020). We conducted 3 cutting date/type of fertilizer trials, harvested with 5, 4 and 3 cuts per year over 3 years. Compared to the chloride based K fertilizer, the application of a sulphate based K fertilizer did not change dry matter yield and fodder quality (NEL-, XP-content) but led to significant higher DCAD in the grass in cut 1 - 3 of all trials over 3 years. The increase of …

The Business Case For Healthy Grasslands-Based Agriculture – Economic And Social Implications, E. Bisangwa, Pat D. Keyser

IGC Proceedings (1977-2023)

Native perennial warm-season grasses (NWSGs) of the United States (U.S.) provide valuable summer forage. Studies have shown their potential within grazing systems as a complement to cool-season forages, as well as their benefits to soil biota, wildlife biodiversity, carbon sequestration and their resiliency to extreme drought and flood events. In this paper, we demonstrate that, in addition to these benefits, NWSGs provide important economic value to beef and dairy producers as a hedge against financial risks posed by overreliance on cool-season grasses.

Breeding Forage Grasses For Increased Heat Tolerance To Combat Climate Change, Eric D. Billman, J. S. Morrison, B. S. Baldwin

IGC Proceedings (1977-2023)

The onset of climate change brings many challenges for forage production in the southeastern United States, where it is projected to become hotter and dryer in the next century. To combat this climatic challenge, recurrent phenotypic selection was conducted in growth chambers on annual ryegrass (Lolium multiflorum Lam.) and orchardgrass (Dactylis glomerata L.) to select seedlings that can germinate and survive at temperatures of 40°C. Following three cycles of selection, germination was increased from < 5% to 45% in annual ryegrass, and from 20% to 80% in orchardgrass. The rate of germination also increased, in both species by a factor of 8x that of the base germplasm. Realized heritability also increased by 40 – 45% for each species by the end of the project. This work successfully improved a quantitative trait using recurrent phenotypic selection using growth chambers as a stable environment and provided the basis for combatting climate change in other outcrossing forage species.

Breeding Small Grains As A Forage, Silage And Cover Crop For The Southern Coastal Plain (Usa) In A Changing Climatic Environment, A. Blount, Marcelo O. Wallau, S. A. Harrison, Cheryl L. Mackowiak, A. Babar, José C. B. Dubeux Jr.

IGC Proceedings (1977-2023)

Forage breeding of small grains in the southern Coastal Plains region of the U.S. mimic many other countries experiencing climate changes and breeding strategies should be similar for improving small grains grown for forage, silage or as cover crops. Significant focus on improvements in stress-adaptation has encouraged members of the SunGrains cooperative to cross, evaluate and develop experimental lines with inherent adaptation to climatic conditions including heat stress, drought tolerance, short-day and long-day forage production periods, and flooded conditions for events with storm-related, short-term durations. Many new cultivars, grown throughout the southeastern U.S. have resulted from breeding selection under abiotic …

Industry Perspectives, Challenges, And Opportunities To Enhance Alfalfa In Warm Climates, J. H. Bouton

IGC Proceedings (1977-2023)

Alfalfa (Medicago sativa L.; aka lucerne) acreage is low in comparison to perennial grasses in warm humid regions. This includes the tropics and subtropics, and in the USA, the Southeastern states. The alfalfa seed industry therefore saw few reasons to target sales and marketing in these regions. This overlooked logical opportunities. In this paper, these opportunities are examined for Southeastern USA. The Southeast contains a majority of beef herd, a high percentage of the dairy herd, and millions of acres suitable for conversion to alfalfa. Alfalfa is also now viewed as the best crop to solve problems inherent with …

Cooperative Evaluation Of Western Hemisphere Grassland Germplasm In Inner Mongolia, Prc, L K. Holzworth, Gu Anlin, J G. Scheetz, M E. Majerus

IGC Proceedings (1977-2023)

Replicated studies were established jointly by Chinese and American scientists in central Inner Mongolia. Both Asian and North American plant materials were included. Results of the Chinese plots show USA saline-tolerant species have potential to assist the Chinese with saline soil reclamation. On saline sites, USA cultivars rated the best stands and had the highest yields. Generally, Chinese desert steppe species outperformed USA upland entries with the Chinese legumes establishing the best stands and producing the most biomass.

Palatability Of Alfalfa (Medicago Sativa L.) And Orchard Grass (Dactylis Glomerata L.) Silages, R. D. Améndola-Massiotti, J. A. Burgueño, M. Concepción, L. Cruz

IGC Proceedings (1977-2023)

The objective was to compare palatability with different methodologies for characterizing silages at Chapingo Autonomous University, México. Eight silages were used resulting from an experiment which evaluated effects of cutting time (08:00 and 14:00), time of wilting (0, 1 and 2 h) and use of lactic bacteria inoculant on properties of alfalfa (Medicago sativa L.) and orchard grass (Dactylis glomerata L.) silages. Organoleptic properties (odor, color, texture, moisture) were assessed by trained observers, using as categories: excellent, good, fair and poor. Dry matter content, CO₂ rate of production and pH were also measured. For the evaluation of …

The Future Of Clovers In Forage Systems And As Cover Crops, J. H. Bouton, John R. Caradus

IGC Proceedings (1977-2023)

Clovers (Trifolium spp.) are the most widely used genera of legumes in forage systems, although only a limited number of the hundreds of perennial and annual species are commercially available. The number of varieties available within each of the main commercial species can be high and demonstrates past breeding achievements. Success relates to any clover’s ability to persist in mixtures with other forage species, across a range of soil types, management systems, and climates, while providing animal nutrition and biologically fixed nitrogen benefits. Uses range from traditional pasture mixtures with grasses to inclusion in multi-species mixtures, and as cover …

Economic Benefits Of Sustainable, Forage-Based Cattle Systems In Colombia And Nicaragua, S. Burkart, K. Enciso, M. Diaz, R. Van Der Hoek

IGC Proceedings (1977-2023)

Forage-based cattle systems play a key role in rural economies of developing countries in terms of food security and poverty alleviation, particularly in tropical Latin America. However, they are often related to being a major cause of negative environmental impacts by contributing to increased greenhouse gas emissions, land degradation, and the reduction of biodiversity. Significant resources have been allocated to research and development in forage material improvement, including selection and breeding. A broad range of improved materials were released by private and public sector actors showing superior characteristics in terms of productivity and environmental impacts compared to native or naturalized …

Fermentation Control And Ethanol Production Of Total Mixed Ration Prepared With Apple Pomace And Microbial And Chemical Additives, J. Fang, Yimin Cai

IGC Proceedings (1977-2023)

The objective of this study is to evaluate the impacts of moisture adjustment, lactic acid bacteria (LAB) inoculant and chemical additives on fermentation characteristics and ethanol production of a total mixed ration (TMR) containing apple (Malus domestica) pomace. The TMR was prepared with apple pomace, corn, wheat bran, soybean meal, timothy, and alfalfa hay. In Experiment 1, the proportion of apple pomace was 150 g/kg of dry matter (DM), and the moisture of the TMR was unadjusted (control) or adjusted to 450, 500, and 550 g/kg, respectively. In Experiment 2, the same ingredient proportions as in experiment 1 …

Modelling Leucaena Biomass Under Rainfed Production Systems Of Semiarid Regions, M. J. D. Cândido, J. L. G. Santos, A. C. R. Cavalcante, S. R. Maranhão, M. A. Santos, J. M. Osorio Leyton

IGC Proceedings (1977-2023)

The climatic variability of semiarid regions is the main source of uncertainties associated with forage and animal production, indicating a need for tools that accurately estimate forage production in order to construct a forage budgeting plan for livestock. This study simulated the biomass of Leucaena (Leucaena leucocephala) using the PHYGROW model in four locations located in Brazilian Semiarid. The work was carried out based on field data collected from 2019 to 2021. After sowing in 2018, leucaena was harvested when it reached 200 cm and to a target residual height of 70 cm. The biomass (fresh matter) was …

Canopy Characteristics And Growth Rate Of Bahiagrass Monoculture And Mixtures With Rhizoma Peanut, N. Caram, Lynn E. Sollenberger, Marcelo O. Wallau, C. H. Wilson

IGC Proceedings (1977-2023)

Understanding relationships among canopy light interception (LI), canopy height and structure, and leaf area index (LAI) informs management decisions and can improve efficiency of forage-livestock systems. In a long-term experiment in Florida, USA, we assessed the LI, LAI and sward height relationships of rhizoma peanut (Arachis glabrata Benth., RP)-bahiagrass (Paspalum notatum Flügge) mixed swards compared with bahiagrass monoculture to determine whether changes in canopy structure affect herbage accumulation (HA) rate due to changes in radiation use. Treatments were arranged in a semi-factorial, split-plot design (r=4). Bahiagrass monoculture and bahiagrass-RP mixtures were whole-plot treatments. Sub-plot treatments were an undefoliated …

3rd Annual Hu Research Symposium Program 2021, Akeisha Belgrave, Erica Ward, Rebekah Harriger

Harrisburg University Research Symposium: Highlighting Research, Innovation, & Creativity

3rd Annual HU Research Symposium program and schedule of presenters. Presentations were held April 21st, 2021 virtually on the Teams platform.

2019: Designing A Wikia Fandom Page, Brandon Carl

Harrisburg University Research Symposium: Highlighting Research, Innovation, & Creativity

No abstract provided.

Effectiveness And Cost Of Shrub Removal Methods In Degraded Woodlands Being Converted To Silvopasture, S. Cartoni-Casamitjana, M. J. Renz

IGC Proceedings (1977-2023)

Transforming degraded woodlands to silvopasture is of interest in the Midwestern USA as it increases profitability of farms and benefits animal health. Invasive shrubs within woodlands, however, are a major obstacle to silvopasture establishment. Research was undertaken to evaluate the effectiveness, cost and resulting herbaceous canopy light interception of common brush-control methods when used alone or integrated over a two-year timeframe. Five treatments were established in a randomized complete block design. In the first year, treatments were either forestry mowed (mow) or rotationally grazed by goats (goats) at a stocking density of 5700 to 6000 kg per hectare. In the …

Herbage Accumulation And Mass In Massai Grass Plots Mixed With Forage Peanut And Fertilized With Nitrogen, Carlos A. B. Carvalho, M. O. Leal Junior, P. P. Carneiro, J. V. B. Ramos, N. Schultz, J. C. C. Almeida, A. J. Paiva

IGC Proceedings (1977-2023)

The objective of this work was to evaluate herbage accumulation and mass during the growing season of Massai grass mixed with peanut forage and fertilized with nitrogen. The work was carried out at Federal Rural University of Rio de Janeiro, Brazil, from 11/2021 to 03/2022. A randomized block experimental design was used, in plots of Massai grass Megathyrsus maximus, in a factorial arrangement, with seven replications. Four treatments formed by the combination of the presence or absence of Archis pintoi and nitrogen fertilization (0 and 50 kg ha^-1 of N). Canopy heights of the plots were evaluated weekly …

Brs Sarandi: A New Andropogon Gayanus Cultivar For Tropical Pastures, Marcelo A. Carvalho, C. E. F. Lazarini, Allan K. B. Ramos, Gustavo J. Braga, Claudio T. Karia

IGC Proceedings (1977-2023)

BRS Sarandi is adapted to low and medium fertility soils. It has a medium-high height, with a semi-erect growth habit and a high total number of tillers. The annual productivity of dry matter is 11 t ha-1, concentrated in the rainy season (90%). Of the total DM produced, 60% are leaves. The levels of crude protein (CP), in vitro dry matter digestibility (IVDMD), neutral detergent fiber (NDF) and acid detergent fiber (ADF) are, on average, 8.7, 56.5, 66.7 and 38.2%, respectively. . The average daily weight gain was 0.7 kg/head/day, the gain per was and 1.7 kg ha-1 day with …

The Molecular Mechanism Of Seed Physical Dormancy In Legume Forage, Maofeng Chai, Z. Wen, Hui Li, Z-Y. Wang

IGC Proceedings (1977-2023)

Legume forage seeds have evolved a specific dormancy trait, physical dormancy, to inhibit germination until favorable conditions appear. Physical dormancy is an adaptive trait that widely exists in higher plants and plays a vital role in maintaining natural seed banks. This kind of dormancy is caused by a waterimpermeable layer that blocks water and oxygen from the surrounding environment. The outermost cuticle of the seed coat is critical for establishing seed physical dormancy. The molecular mechanism underlying physical dormancy remains largely elusive. Using Medicago (Medicago truncatula) as a model, we set up the legume plant to study seed …

Production And Management Simulation Of Family Pasture In Different Pastoral Areas Based On Ommlp Model, Chen Chen, G. D. Han, Z. G. Li, S. J. Lv

IGC Proceedings (1977-2023)

Family ranch grassland livestock production optimal management model was used to simulate the grassland supply and livestock demand, family economic status under different stocking rates senarion with collection of grassland, livestock, and economics data from Wuzhumuqin Banner and Tongliao as two types of pastoral areas in Inner Mongolia Autonomous Region. The livestock is grazing all year long in Wuzhumuqin Banner, but the livestock is grazing in summer and feeding in hovel in winter in Tongliao, which we call it as semi-farming and semi-pastoral area. The results showed that summer grassland productivity could meet the energy demand of livestock. As the …

Mass Production And Morphology Of Brauna Brachiaria Under Different Nitrogen Rates In The Brazilian Savannah, E. A. Collao-Saenz, M. F. P. Carvalho, P. S. Ribeiro, R. A. De O. Rodrigues, T. A. Cavalcante

IGC Proceedings (1977-2023)

Nitrogen is the nutrient that most contributes to increase forage productivity and quality. The objective was to evaluate Brauna brachiaria (Urochloa brizantha cv. Brauna) submitted to nitrogen doses in the Brazilian savannah through the total and green mass production, leaf:stem and brachiaria:weed ratio. Plots were established in a randomized block design, with four replications and four N doses 0, 50, 100 and 150 kg N/ha). After the uniformization cut, the data collect cycles occurred when the canopy reached 30 cm average height. Samples were taken until 15 cm from the ground in an area of 0.25 m² . …