Digital Commons Network^™

Karl Van Meter Oral History, Karl Van Meter

Raymond College

No abstract provided.

Modified Critical Chain Scheduling For Construction Projects, Eslam Sayed Meabed, Sameh Youssef Mahfouz, Ahmed Alhady

Civil Engineering

No abstract provided.

High-Yield And Rapid Isolation Of Extracellular Vesicles By Flocculation Via Orbital Acoustic Trapping: Float, Joseph Rufo, Peiran Zhang, Zeyu Wang, Yuyang Gu, Kaichun Yang, Joseph Rich, Chuyi Chen, Ruoyu Zhong, Ke Jin, Je He, Jianping Xia, Ke Li, Jiarong Wu, Yingshi Ouyang, Yoel Sadovsky, Luke P. Lee, Tony Jun Huang

Faculty Publications

Extracellular vesicles (EVs) have been identified as promising biomarkers for the noninvasive diagnosis of various diseases. However, challenges in separating EVs from soluble proteins have resulted in variable EV recovery rates and low purities. Here, we report a high-yield ( > 90%) and rapid ( <  10 min) EV isolation method called FLocculation via Orbital Acoustic Trapping (FLOAT). The FLOAT approach utilizes an acoustofluidic droplet centrifuge to rotate and controllably heat liquid droplets. By adding a thermoresponsive polymer flocculant, nanoparticles as small as 20 nm can be rapidly and selectively concentrated at the center of the droplet. We demonstrate the ability of FLOAT to separate urinary EVs from the highly abundant Tamm-Horsfall protein, addressing a significant obstacle in the development of EV-based liquid biopsies. Due to its high-yield nature, FLOAT reduces biofluid starting volume requirements by a factor of 100 (from 20 mL to 200 µL), demonstrating its promising potential in point-of-care diagnostics.

Neuromodulation Techniques In Chronic Refractory Coccydynia: A Narrative Review, Richard Morgan

All Publications

Refractory coccydynia is a condition characterized by severe coccygeal pain and poses a challenging management dilemma for clinicians. Advancements in neuromodulation (NM) technology have provided benefits to people experiencing chronic pain that is resistant to standard treatments. This review aims to summarize the spectrum of current NM techniques employed in the treatment of refractory coccydynia along with their effectiveness. A review of studies in the scientific literature from 2012 to 2023 was conducted, revealing a limited number of case reports. Although the available evidence at this time suggests significant pain relief with the utilization of NM techniques, the limited scope …

How I Obtained My Phd Admission Letter: A Reflective Interaction-Based Autoethnography, Qing Xu, Kei Wei Chia

The Qualitative Report

This account utilises autoethnography to explore how the “one-child generation’s” cultural context influences behaviours and character traits, focusing on the first author’s experiences during a 5-month doctoral program application. It examines interactions with the employer, unacquainted individuals, intermediaries, and family, encapsulated in three Episodes, to analyse the personality traits of this generation. The findings reveal that, though deeply rooted in traditional culture, character traits such as risk aversion, caution, and family dependency are not immutable. It highlights the potential for personal transformation through inward growth, proactive external engagement, and the support of families who challenge traditional norms. In terms of …

Degradation Of The Mechanical Properties And Hydrogen Generation In Cement Under Gamma Irradiation Assessed By Atomistic Simulation, Omar Al Najjar

Theses and Dissertations

Although understanding the effect of the gamma-ray on cement-based materials is essential for many applications, such as the concrete contaminate of nuclear reactors or the storage of radioactive waste in cement-based waste forms, such understanding is still not fully developed. The importance of having such an understanding is becoming of utmost importance, especially with calls to extend the lifetime of nuclear power plants, and also due to some recent incidents of failures of the concrete structure in the nuclear fields. In this work, the details of preparing three molecular models as a representative structure of the main binding phase of …

Emoji Use In Social Media Posts: Relationships With Personality Traits And Word Usage, Shelia Kennison, Kameryn Fritz, Maria Andrea Hurtado Morales, Eric Chan-Tin

Computer Science: Faculty Publications and Other Works

Prior research has demonstrated relationships between personality traits of social media users and the language used in their posts. Few studies have examined whether there are relationships between personality traits of users and how they use emojis in their social media posts. Emojis are digital pictographs used to express ideas and emotions. There are thousands of emojis, which depict faces with expressions, objects, animals, and activities. We conducted a study with two samples (n = 76 and n = 245) in which we examined how emoji use on X (formerly Twitter) related to users’ personality traits and language use …

Identification Of New Egfr Inhibitors By Structure-Based Virtual Screening And Biological Evaluation, Qinlan Li, Shanhe Wan, Zhonghuang Li, Jiajie Zhang, Xiaoyun Wu

Faculty, Staff and Student Publications

Epidermal growth factor receptor (EGFR) inhibitors have been used in clinical for the treatment of non-small-cell lung cancer for years. However, the emergence of drug resistance continues to be a major problem. To identify potential inhibitors, molecular docking-based virtual screening was conducted on ChemDiv and Enamine commercial databases using the Glide program. After multi-step VS and visual inspection, a total of 23 compounds with novel and varied structures were selected, and the predicted ADMET properties were within the satisfactory range. Further molecular dynamics simulations revealed that the reprehensive compound ZINC49691377 formed a stable complex with the allosteric pocket of EGFR …

Unraveling The Complex Web Of Fibromyalgia: A Narrative Review., Sarah Al Sharie, Scott J Varga, Lou'i Al-Husinat, Piercarlo Sarzi-Puttini, Mohammad Araydah, Batool Riyad Bal'awi, Giustino Varrassi

Women’s Health Articles

Fibromyalgia is a complex and often misunderstood chronic pain disorder. It is characterized by widespread musculoskeletal pain, fatigue, and heightened sensitivity, and has evolved in diagnostic criteria and understanding over the years. Initially met with skepticism, fibromyalgia is now recognized as a global health concern affecting millions of people, with a prevalence transcending demographic boundaries. The clinical features and diagnosis of fibromyalgia encompass a range of symptoms beyond pain, including sleep disturbances and cognitive difficulties. This study emphasizes the importance of a comprehensive evaluation for accurate diagnosis, considering the shift from tender point reliance to a more holistic approach. Etiology …

Viewing The World Through The Prism Of Cross-Cultural Romances: Film Review Of Christmas As Usual (2023) And Further Reflections, Raja Ramanathan

Markets, Globalization & Development Review

No abstract provided.

Flavors And Frailties Of Globalization, Nikhilesh Dholakia, Deniz Atik

Markets, Globalization & Development Review

No abstract provided.

Use Of The Ftir Technique As A Diagnostic And Monitoring Tool For Cancer Patients: A Review Of A Decade (2010–2022), Hiba Ghmeedh Adhab, Shaymaa Awad Kadhim, Mohammed Abduljaleel Hussein

Maaen Journal for Medical Sciences

The use of spectroscopy in the analysis of carcinoid tumors depends on this method's capacity to reveal details about the biochemical composition and the structure of the tissue. Numerous clinical investigations have shown potential benefits of employing spectroscopic techniques. These techniques have a number of advantages, including minimal implementation costs, convenience of use, and the ability to be conducted using small, portable instruments without the need for specialized equipment or professional interpretation. This article discusses several research that used FTIR spectroscopy to extract spectral characteristics from various biological materials in order to diagnose diseases in a concise manner. It was …

Protein And Polysaccharide-Based Optical Materials For Biomedical Applications., Gianna Riviello, Brendan Connor, Jake Mcbrearty, Gianna Rodriguez, Xiao Hu

College of Science & Mathematics Departmental Research

Recent advances in biomedical research, particularly in optical applications, have sparked a transformative movement towards replacing synthetic polymers with more biocompatible and sustainable alternatives. Most often made from plastics or glass, these materials ignite immune responses from the body, and their production is based on environmentally harsh oil-based processes. Biopolymers, including both polysaccharides and proteins, have emerged as a potential candidate for optical biomaterials due to their inherent biocompatibility, biodegradability, and sustainability, derived from their existence in nature and being recognized by the immune system. Current extraction and fabrication methods for these biomaterials, including thermal drawing, extrusion and printing, mold …

Honest Signalling Of Age In A Territorial Breeder, Brian A. Hoover, Walter H. Piper

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Age often indicates phenotypic quality, ecological experience or social status in animals. Consequently, behavioural signals in territorial animals that accurately convey age to potential mates or rivals might provide useful information for both signaller and receiver about the likelihood of aggression. We tested whether male territorial yodels convey information about age in the common loon, Gavia immer. Using a sample of male loons of known age, we found that the dominant frequency of Fintro3, a dominant syllable in the beginning sequence of a male yodel, increases strongly with age, but we were unable to replicate an earlier finding linking …

Predicting Sedentarism And Its Impact On Caloric Requirements, Jacob Michels, John C. Beghin

Yeutter Institute International Trade Policy Review

A recent study conducted by PhD candidate Jacob Michels and Agricultural economist John Beghin delves into the question of whether global estimates of food insecure populations need a reevaluation of their methodology to account for increasing sedentarism. This reevaluation is prompted by the increasing prevalence of sedentary lifestyles worldwide, which calls for a redefinition of caloric thresholds indicating the onset of food insecurity. In this short article, we provide a nontechnical summary of their investigation recently published in Michels and Beghin (2024).

Effects Of Hemiparasites In Grassland Restorations Are Not Universal, Anna Scheidel, Victoria Borowicz

Faculty Publications – Biological Sciences

Root hemiparasites infiltrate the vascular tissue of host roots to acquire water and nutrients, which often reduces host growth. Hemiparasites are postulated to be keystone species in grassland communities if they suppress dominant species and increase plant community biodiversity, and ecosystem engineers if they increase nutrient accessibility for surrounding species. We examined keystone effects by evaluating species richness and evenness in 1 m2 plots in a recent prairie restoration where Castilleja sessiliflora was naturally present or absent, and in a longer-established prairie restoration with or without Pedicularis canadensis. We examined ecosystem engineer effects by determining nitrate and phosphate concentrations …

Sleep Restriction Alters The Integration Of Multiple Information Sources In Probabilistic Decision-Making, Jeryl Y. L. Lim, Johanna M. Boardman, Clare Anderson, David L. Dickinson, Daniel Bennett, Sean P. A. Drummond

ESI Publications

The detrimental effects of sleep loss on overall decision-making have been well described. Due to the complex nature of decisions, there remains a need for studies to identify specific mechanisms of decision-making vulnerable to sleep loss. Bayesian perspectives of decision-making posit judgement formation during decision-making occurs via a process of integrating knowledge gleaned from past experiences (priors) with new information from current observations (likelihoods). We investigated the effects of sleep loss on the ability to integrate multiple sources of information during decision-making by reporting results from two experiments: the first implementing both sleep restriction (SR) and …

Exploring Referral And Service Utilization Patterns Within An Outpatient Interdisciplinary Pediatric Chronic Pain Program, Aimee Hildenbrand, Christina M Amaro, Benjamin Bear, Catherine Soprano, Katherine S Salamon

Department of Medicine Faculty Papers

PURPOSE: We examine referral sources and clinical characteristics for youth presenting to an outpatient interdisciplinary pediatric chronic pain program.

PATIENTS AND METHODS: Referral data were extracted from the electronic health record. PROMIS Pediatric Anxiety and Pain Interference Scales were administered at an initial evaluation visit.

RESULTS: The program received 1488 referrals between 2016 and 2019, representing 1338 patients, with increasing volume of referrals over time. Referrals were primarily from orthopedics (19.6%), physical medicine and rehabilitation (18.8%), neurology (14.4%), and rheumatology (12.6%). Patients referred were primarily female (75.4%), White (80.1%), English-speaking (98.4%) adolescents (median=15.0 years). Of those referred, 732 (54.7%) attended …

Neighborhood Environment And Poor Maternal Glycemic Control-Associated Complications Of Gestational Diabetes Mellitus, Leela V. Thomas, Claudine T. Jurkovitz, Zugui Zhang, Mitchell R. Fawcett, M. James Lenhard

Department of Medicine Faculty Papers

INTRODUCTION: Risk of complications due to gestational diabetes mellitus is increasing in the U.S., particularly among individuals from racial minorities. Research has focused largely on clinical interventions to prevent complications, rarely on individuals' residential environments. This retrospective cohort study aims to examine the association between individuals' neighborhoods and complications of gestational diabetes mellitus.

METHODS: Demographic and clinical data were extracted from electronic health records and linked to American Community Survey data from the U.S. Census Bureau for 2,047 individuals who had 2,164 deliveries in 2014-2018. Data were analyzed in 2021-2022 using Wilcoxon rank sum test and chi-square test for bivariate …

Barriers And Facilitators To Enhance Interprofessional Education For Rehabilitation Science Graduate Students, Mary A. Riopel, Kimberly Wynarczuk, Taylor Grube

The Qualitative Report

Interprofessional education (IPE) aims to develop healthcare practitioners who work effectively in teams, demonstrate strong communication skills, respect others, and have a working knowledge of the roles and responsibilities of other professionals. Of identified research to date, it is unclear what students perceive as important for effective IPE delivery and learning. The purpose of this study was to identify graduate students' perceptions of facilitators and barriers to learning interprofessional practice using phenomenology. Three semi-structured focus groups were conducted including athletic training, occupational therapy, or speech-language pathology students and the transcripts were analyzed using thematic analysis. Four themes emerged about IPE …

On Restorative Validity: Reorienting Inquiry Toward Peace, Justice, And Healing, Giovanni P. Dazzo

The Qualitative Report

This work begins with a simple premise: (re)imagining a healing and restorative space for inquiry. Drawing on the work of John H. Stanfield II (2006), who first suggested the restorative functions of qualitative inquiry, this manuscript forms the basis for an axiologically-actuated conceptual model, restorative validity, which asks what it would take to (re)humanize researcher and researched alike. Beginning with the knowledge of co-researchers in our collective, the formulation of this framework was organized to understand the importance of orienting our research and ourselves toward relationships, justice, and liberation. After this review, I discuss a series of reflexive questions, rooted …

Exploring Primary School Teacher Perspectives On Adaptability And Its Links With Classroom Management And Psychological Wellbeing: A Qualitative Inquiry, Robyn Davis, Andrew Holliman, Michael John Burrows, Daniel Waldeck, David Holliman

The Qualitative Report

Teacher shortage is a major concern for educational institutions. One key psychological resource for teachers that may reduce teacher shortage (e.g., prevent burnout, improve wellbeing) is teacher adaptability (i.e., the capacity to adjust to situations of novelty and change). Indeed, teacher adaptability is known to be associated with positive functioning and wellbeing. However, little qualitative research has been conducted exploring how adaptability may be experienced by teachers. The present study set out to explore the unique perspective of a sample of teachers on their adaptability and its links with classroom management and wellbeing. Semi-structured interviews were conducted with four primary …

Visual Methods For Qualitative Research With Older Refugees: Reflection On Strengths And Drawbacks, Prince Chiagozie Ekoh, Christine A. Walsh

The Qualitative Report

Although older refugees have similar characteristics and vulnerabilities as other populations that have benefited from visual research methods, there is scarce evidence of these methods being used for qualitative social work studies with older refugees. In this article, we discuss the application of visual methods for social work research with older refugees for a better understanding of their experiences and challenges, highlighting how it can be evocative, improve discussions by reaching senses that ordinary interviews cannot grasp, avoid re-traumatisation during research, and build resilience and coping in older refugees. We propose that visual methods could address power dynamics that privilege …

Sexuality Research During A National Lockdown: Reflexive Notes And Lessons From My Ph.D. Fieldwork, Tshepo B. Maake Mr

The Qualitative Report

The COVID-19 pandemic presented challenges for qualitative researchers since many countries had to implement lockdown policies to control the spread of the virus. Within the South African context, research on sexual minority identities and experiences is automatically sensitive and risky given the extent of intolerance and high regard for heteronormative ideologies and beliefs that continually exclude sexual minorities from the “normal.” The sensitivity is intensified during a national lockdown since there is an excessive reliance on digital public spaces to recruit participants and conduct interviews. Based on the experience of Ph.D. fieldwork, this paper pays attention to a sexuality researcher’s …

Walking Toward The Demonumentalization Of Qualitative Research: A Collaborative Autoethnography Account While Producing An Educational Podcast, Carmen H. Guerrero-Nieto, Alvaro H. Quintero-Polo

The Qualitative Report

This article examines how two teacher educators, as researchers and as research teachers, engaged in a collaborative interpretation of their autoethnographies about questioning an instrumentalist and positivist research culture in the field of English Language Teaching (ELT). The autoethnographies simultaneously emerged from the research activities related to the production of a bilingual podcast named “Conversing about "Investigación Cualitativa.” Specifically, the authors conducted a qualitative study of autoethnographic and collaborative nature while working on their podcast. The data were individual written retrospective accounts, which were shared, discussed, and interpreted in online live meetings. The outcomes of the study were …

A Path To Food Self-Provisioning And Experiences From Learning New Skills: An Autoethnographic Depiction, Toni Ruuska

The Qualitative Report

In this autoethnographic depiction, I tell a story of change and renewal. In the narrative, I present a story of personal choices and epiphanies that have changed the course of my life. At the turning point, I portray the process of learning new skills regarding food self-provisioning. I come from a privileged, but de-skilled, middle-class suburban background, and the past four years has been a diverse journey of insecurity, alienation, and fatigue, but also of learning, empowerment, and self-realization. From a person with limited skills, to an at least somewhat skilled food neo-self-provisioner, I have partaken in a process of …

A Mixed-Methods Study Of Compassionate Mind Training For Pupils (Cmt-Pupils) As A School-Based Wellbeing Intervention, Frances A. Maratos, Wendy Wood, Rory Cahill, Yessica Abigail Tronco Hernández, Marcela Matos, Paul Gilbert

School of Health Professions

Objectives: Mental health difficulties in children are increasing, especially following transition from elementary to high-school education. In attempts to mitigate risk of these difficulties, proactive wellbeing interventions are becoming increasingly explored in school settings. Recently, Compassionate Mind Training (CMT) has been shown to be well-accepted and efficacious in promoting school staff wellbeing and prosocial behaviours. This paper outlines the impact of CMT as a pupil wellbeing intervention. Method: Sixty-seven pupils aged 11–12 took part in either Personal, Social, Health and Economic (PSHE) lessons as usual (n=30), or CMT-Pupils (n=37) as their PSHE lessons, over a 5-week period. A mixed-methods quantitative …

Assessing Pattern Of The Pediatric Multisystem Inflammatory Syndrome (Pmis) In Children During The Covid-19 Pandemic: Experience From The Emergency Department Of Tertiary Care Center Of A Low-Middle-Income Country, Saleem Akhtar, Iqra Anis, Kumar Nirdosh, Muhammad Ihsan Tayyab Ihsan, Ahmed Raheem Buksh, Surraiya Bano

Department of Paediatrics and Child Health

Background: Pediatric Multisystem Inflammatory Syndrome (PMIS) is a hyperinflammatory condition affecting multiple organs in children, often resembling incomplete Kawasaki Disease during later phases of COVID-19 infection. Data on PMIS in low-middle-income countries, particularly in emergency department settings, is limited.
Objectives: This prospective observational study at Aga Khan University Hospital, Karachi, aimed to determine the frequency, clinical presentation patterns, and laboratory parameters of children with PMIS visiting the emergency department during the COVID-19 pandemic. Secondary objectives included assessing factors associated with in-hospital mortality.
Methods: From March 2020 to September 2021, patients meeting World Health Organization PMIS criteria were enrolled. COVID-19 testing …

Impact Of Kras Mutations And Co-Mutations On Clinical Outcomes In Pancreatic Ductal Adenocarcinoma, Abdelrahman Yousef, Mahmoud Yousef, Saikat Chowdhury, Kawther Abdilleh, Mark Knafl, Kristin Alfaro-Munoz, Jennifer Peterson, Brandon G Smaglo, Robert A Wolff, Shubham Pant, Michael S Lee, Jason Willis, Michael Overman, Sudheer Doss, Lynn Matrisian, Mark W Hurd, Rebecca Snyder, Matthew H G Katz, Huamin Wang, Anirban Maitra, John Paul Shen, Dan Zhao

Faculty, Staff and Student Publications

The relevance of KRAS mutation alleles to clinical outcome remains inconclusive in pancreatic adenocarcinoma (PDAC). We conducted a retrospective study of 803 patients with PDAC (42% with metastatic disease) at MD Anderson Cancer Center. Overall survival (OS) analysis demonstrated that KRAS mutation status and subtypes were prognostic (p < 0.001). Relative to patients with KRAS wildtype tumors (median OS 38 months), patients with KRASG12R had a similar OS (median 34 months), while patients with KRASQ61 and KRASG12D mutated tumors had shorter OS (median 20 months [HR: 1.9, 95% CI 1.2-3.0, p = 0.006] and 22 months [HR: 1.7, 95% CI 1.3-2.3, p < 0.001], respectively). There was enrichment of KRASG12D mutation in metastatic tumors (34% vs 24%, OR: 1.7, 95% CI 1.2-2.4, p = 0.001) and enrichment of KRASG12R in well and moderately differentiated tumors (14% vs 9%, OR: 1.7, 95% CI 1.05-2.99, p = 0.04). Similar findings were observed in the external validation cohort (PanCAN's Know Your Tumor® dataset, n = 408).

Volume 10, 2023

James Madison Undergraduate Research Journal (JMURJ)

No abstract provided.