Digital Commons Network^™

Computer Aided Design Of Aromatic Foldamer Targeting Protein-Protein Interaction, Bamidele Towolawi

Graduate Student and Postdoctoral Fellow Symposium

With the computational tools developed in our lab for accurate prediction of structures and solution dynamics of aromatic foldamers, we now target protein-protein interaction (PPI) by appending proteinogenic side chains on the external surfaces of the helical aromatic foldamers. Particularly, the activation of a regulatory protein NF-κB, a key player in the inflammatory response and cell proliferation, involves binding of NEMO (NF-κB Essential Modulator) with linear di-ubiquitin. In this study, we designed various sequences based on established protocols and investigated, by utilizing molecular dynamics (MD) simulations, their potential binding to di-ubiquitin, specifically targeting the NEMO binding interface. This study complements …

Location-Based Carbon Dioxide Adjustment Factor For Use In The Design And Deployment Or A Networking Device, Marisol Palmero, Snezana Mitrovic, Gonzalo A Salgueiro, Derek W Engi, Joel Richard Goergen

Defensive Publications Series

Techniques are presented herein that support a carbon dioxide equivalent (CO2eq) adjustment factor that may be applied during the design and deployment of a networking device in, for example, a data center environment. Such an adjustment factor may consider the impact of altitude or elevation on, among other things, power consumption, cooling requirements, heat dissipation, and other related environmental design-impacting considerations.

Large Language Model Driven Automated Software Application Testing, Fei Wang, Kamakshi Kodur, Michael Micheletti, Shu-Wei Cheng, Yogalakshmi Sadasivam, Yue Hu, Zening Li

Defensive Publications Series

Testing, including user interface testing and A/B testing is an important part of application development. It can be difficult for human testers to write appropriate test assertions or checks for user interface tests. Human testing is costly and not scalable. This disclosure describes the use of a large language model (LLM) to automate testing for software applications, including UI tests, A/B tests, and simulating manual QA tests. A dataset of prior known errors in the UI rendering is constructed and labels are associated with different types of errors. Prompt engineering is carried out to develop a library of prompts that, …

Campus Assembly Minutes 03/26 & 3/28/2024, Campus Assembly

Campus Assembly

No abstract provided.

Spartan Daily, March 26, 2024, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2024

Volume 162, Issue 26

Faculty Senate Agenda April 1, 2024, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• 3:00 Call to Order
• Approval of Minutes – March 4, 2024
• 3:05 University Business
• 3:30 Faculty Senate Business
• 3:40 Information
• 4:00 Reports
• 4:05 Old Business
• 4:10 New Business
• Adjourn: 4:30 pm

Comprehensive Constraints On Dark Radiation Injection After Bbn, A. C. Sobotka, A. L. Erickcek, Tristan L. Smith

Physics & Astronomy Faculty Works

We derive constraints on the injection of free-streaming dark radiation after big bang nucleosynthesis by considering the decay of a massive hidden sector particle into dark radiation. Such a scenario has the potential to alleviate the Hubble tension by introducing a new energy component to the evolution of the early Universe. We employ observations of the cosmic microwave background (CMB) from Planck 2018 and South Pole Telescope 2018, measurements of the primordial deuterium abundance, Pantheon+ type Ia supernovae data, and baryon acoustic oscillation measurements from BOSS DR12 to constrain these decay scenarios. Prerecombination decays are primarily restricted by observations of …

Unh Announces 2024 Commencement Speakers, Tania Deluzuriaga, Jeremy Gasowski

UNH Today Archive

No abstract provided.

Generating Crispr Mutations In The Asymmetric Leaves1 Gene Of Arabidopsis, Gabriella J. Rueschhoff, Tara Phelps-Durr

SACAD: Scholarly Activities

The goal of this study is to create new mutations in the ASYMMETRIC LEAVES 1 (AS1) gene of Arabidopsis using CRISPR technology. AS1 is a myb domain transcription factor that represses the KNOX genes, a group of genes involved in maintaining an undifferentiated cell state. AS1 binds to the chromatin remodeling protein Histone Repressor A (HIRA). In animals, HIRA is involved in the permanent suppression of proliferation genes required for early development. The interaction between AS1 and HIRA provides clues to how AS1 maintains suppression at the KNOX genes; however, we must be careful applying what …

A Micrometeor Impact - Lake Wilson, Kansas?, Kenneth R. Neuhauser

SACAD: Scholarly Activities

Much ado about ‘nothing’ was raised when a suspect ‘object’ hit near Lake Wilson, Kansas on August 10, 2006. After a field investigation, a magnetometer survey, thin section analysis, shotgun field tests, and neutron activation analyses (NAA), no 100% conclusive physical evidence exists as to what caused the impact. However, enough NAA chemical evidence was found to suggest a micro-meteor was what created an 18” wide and 12” deep ‘crater’ at the site.

Confidence In Crises: School Nurses' Perceptions Of Self-Efficacy In Active Shooter Emergency Preparedness, Titilayo Idowu

Dissertations

The incidence and number of mass school shootings have increased since the first reported school shooting in 1840. Since then, extensive research has been conducted to explore school violence's underlying causes and precursors, resulting in many recommendations for preventative and mitigating practices. However, no national standard or legislation currently dictates the minimal requirements for competencies and training among school nurses in preparation for active shooter incidents. This interpretive qualitative phenomenological study was conducted to explore the lived experiences of postlicensure K-12 school nurses regarding their self-efficacy and confidence to prevent, protect, mitigate, respond, and recover from a school shooting incident. …

Hearing Loss Vs Length Of Employment In The Steel Industry, Sarah Jane Hattle

Student Theses and Dissertations

The purpose of this research was to investigate if there was a relationship between hearing loss and length of employment in the steel industry. Participants included 11 males that worked in the steel industry. Participants completed questionnaires regarding demographics, employment, and noise exposure, as well as took part in an audiological exam. The results of the audiological evaluations showed that 45% of participants had hearing loss in the right ear, 36% of participants had hearing loss in the left ear, and 36% of participants had loss in both ears. While there was no significant relationship between hearing loss and the …

An Examination Of The Relational Aspect Of Cohesive Co-Teaching Relationships, Debra L. Byers

Student Theses and Dissertations

Co-teaching has developed as a successful instructional strategy to support various learning requirements and differentiation, especially as more students with disabilities are integrated into general education classrooms. To establish efficacious co-teaching partnerships, it is important to surmount some interpersonal barriers and apply relational skills. To better understand the dynamics of meaningful co-teaching relationships, this phenomenological study interviewed seven co-teaching pairs who had participated in the Arkansas Co-Teaching Project's year-long professional development program. Additionally, to understand how to foster equality and synergy, both individual and group interviews were conducted. Findings highlighted the need for more intensive training and support systems to …

Changing The Culture Of Secondary School Mathematics: What Are The Effects Of Interventions On Student Attitudes, Beliefs, And Motivation?, Meagan Coronado

Student Theses and Dissertations

In this study, 80 ninth-grade students enrolled in Algebra I from a high school in south Texas completed the Implicit Theories of Intelligence Scale for Children (ITIS) Survey and the Attitudes Toward Mathematics Inventory (ATMI) Survey, before and after a set of interventions. The students were divided into one of four groups, three with applied intervention and one control group: intelligence theory, utility value theory, both intelligence theory and utility value theory, and no interventions (control group). Analyses were conducted to determine the impact of the interventions on the overall scores on the ITIS and ATMI surveys. The results showed …

The Impact Of Covid-19 On The Utilization Of Early Magnetic Resonance Imaging (Emri) In The Assessment Of Acute Uncomplicated Low Back Pain (Lbp) And The Subsequent Effect On Health Care Service Utilization And Patient Outcomes, Kimberly F. Radcliffe

MUSC Theses and Dissertations

OBJECTIVES: To examine changes in MRI rates between Pre-COVID-19 period (Feb-April 2019) and COVID-19 period (Feb-April 2020) among commercially insured patients aged 18-60 with a diagnosis of acute LBP, and to analyze differences in patient characteristics and outcomes between the time periods. Additionally, to examine the impact of eMRI on patient outcomes and health care costs for patients in the COVID-19 period.

DESIGN/METHODS: Using IBM® MarketScan® Commercial Database (MarketScan) we performed a quantitative pre-post comparative retrospective observational study of 117,150 total patients to examine adjusted differences in patient characteristics and rates of MRIs between time periods. We analyzed 49,020 patients …

Unh Announces 2024 Commencement Speakers, Tania Deluzuriaga

Media Relations

No abstract provided.

Mental Health-Seeking Behaviors For Hispanic Individuals In The United States, Ana Aluisy

USF Tampa Graduate Theses and Dissertations

Purpose: This dissertation examines the complexities of mental health service (MHS) utilization among Hispanic individuals in the United States, elucidating myriad factors influencing help-seeking behaviors within this community.

Methods: This dissertation unpacks the barriers to and facilitators of MHS utilization through an integrative review and two cross-sectional studies among Hispanic college students and residents of El Paso. Additionally, the latter two studies assessed attitudes towards mental health services (ATMHS) within these subgroups.

Results: Barriers to MHS utilization included a preference for the Spanish language and the varied role of gender (male or female). The facilitators of MHS utilization included higher …

Usa V. Eric Triplett

2024 Decisions

USDC for the Western District of Pennsylvania

Examining Childhood Trauma And Substance Use Problems Among Justice-Involved Adolescents In Florida, Skye C. Bristol

USF Tampa Graduate Theses and Dissertations

The purpose of this dissertation was to assess the relationship between childhood trauma and substance use problems as latent constructs among justice-involved adolescents (JIA). Additionally, racial differences and spatial analyses were examined. Previous research underscores the limitations of conceptualizing childhood trauma solely through Adverse Childhood Experiences (ACEs). This justified integrating child welfare involvement, or out-of-home placement, as an additional indicator to develop a comprehensive scope of childhood trauma among JIA. Furthermore, current literature established that childhood trauma is a key predictor of substance misuse among JIA. However, the lack of a standardized measure of substance misuse across juvenile justice systems …

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2024 Helehan Borrow Material Submittal #2 (Dated March 12, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Impacts Of Nature-Based Sediment Restoration Practices On Coastal Wetland Soil Biogeochemistry, Jacob Z. Cheng

LSU Master's Theses

Coastal marshes provide many valuable ecosystem services. However, these wetlands are threatened worldwide, being subject to sea level rise, sediment starvation, subsidence, coastal edge erosion, etc. Many efforts are being made to counteract this wetland loss and preserve the ecosystem services. Two such methods are sediment diversion and the thin layer placement (TLP) of dredged sediment.

Sediment diversion involves reconnecting the main channel of a river body to disconnected wetlands, supplying much needed soil-building materials. However, this method affects the salinity of the waters, introducing large amounts of freshwater into the system. Salinity changes can affect marsh biogeochemistry. Most ecological …

Aggressive Behaviors Related To Delirium In Hospitalized Older Adults: A Systematic Review, Julia D. Trahan

LSU Master's Theses

This is a systematic review of the aggressive behaviors related to delirium in hospitalized older adults. The objective of this study was to review relevant literature regarding the moderation of delirious related aggressive behaviors within a hospital setting and examining the extent of interventions being conducted with aggression being a main factor. The eligibility factors for studies to be included were as follows: diagnosis of delirium, aggressive behaviors or agitation present, study occurring within a hospital setting, the goal of preventing aggressive behaviors, and participants must be over the age of 65. Academic Search Complete, PsychINFO, MEDLINE, SocINDEX, CINHAL Complete …

Petition For Redress Or Telephonic Harassment? When Calling The Government Is A Crime, Daniel Caballero

Fordham Law Voting Rights and Democracy Forum

The telephone has enabled significant enhancements in communication. However, it has also brought with it abuses. One of these is telephonic harassment. The states and the federal government have passed laws that criminalize this inappropriate and psychologically harmful use of telephones. This Article assumes that these laws are constitutional when the caller harasses an ordinary citizen. But the First Amendment protects the right to petition the government for redress of grievances. So, what happens when the caller is both petitioning the government and intending to harass a government official? Does the First Amendment protect telephonic harassment of a public official? …

Iran's Nuclear Program: A Struggle For Security And Modernity, Sina Azodi

USF Tampa Graduate Theses and Dissertations

This dissertation explores the historical evolution of Iran's nuclear program from its inception in the 1950s to the signing of the Joint Comprehensive Plan of Action (JCPOA) in 2015. It examines how threat perceptions have, over the decades, influenced Iran's nuclear posture, leading the Iranian political leadership to adopt a hedging strategy that extends beyond changes in ruling regimes. This study employs the Proliferation Strategy Theory (PST) as its theoretical foundation. This framework helps in dissecting the dynamics between threat perceptions and the candidate state's adopted nuclear posture. The principal findings of this dissertation highlight the direct impact of regional …

Development Of 3d Printed Anatomically Equivalent Thermoplastic Polyurethane Conduits For Peripheral Nerve Regeneration, Allen Zennifer M

Theses and Dissertations

Three-dimensional (3D) printing is an emerging tool for creating patient-specific tissue constructs analogous to the native tissue microarchitecture. In this study, anatomically equivalent 3D nerve conduits were developed using thermoplastic polyurethane (TPU) by combining reverse engineering and material extrusion (i.e., fused deposition modelling) technique.

Printing parameters were optimized to fabricate nerve-equivalent TPU constructs. The TPU constructs printed with different infill densities supported the adhesion, proliferation, and gene expression of neuronal cells. Subcutaneous implantation of the TPU constructs for three months in rats showed neovascularization with negligible local tissue inflammatory reactions and was classified as a non-irritant biomaterial as per ISO …

Modeling Studies Of An Intensified Reforming/Fischer-Tropsch Synthesis Process For Gas To Liquid Conversion, Brian Gray

USF Tampa Graduate Theses and Dissertations

Despite rigorous study and advancement in fields of green energy, the world's transportation industry remains poised to continue reliance on liquid hydrocarbon fuels. To date, the primary source of diesel and jet fuels is the petroleum industry; however, continuing trends in rising greenhouse gas emissions present a need for study into processes for the production of synthetic hydrocarbon fuels. The most promising technologies to meet this goal are gas-to-liquid (GtL), biomass-to-liquid (BtL) and coal-to-liquid (CtL). The commonality of these technologies is that they utilize a feedstock to produce carbon monoxide and hydrogen gas (syngas) which becomes the building blocks of …

Older Adults Are At Greater Risk Of Opioid Use Disorder In Communities With High Social Vulnerability, Tse-Chuan Yang, Seulki Kim, Stephen A. Matthews, Carla Shoff

Population Health Research Brief Series

The prevalence of opioid use disorder (OUD) among older adults has increased and imposes a heavy burden on the health care system in the United States. This brief summarizes findings from a study that used data from the Centers for Medicare and Medicaid Services to examine how county characteristics contributed to the prevalence of OUD among Medicare beneficiaries age 65+ in U.S. counties in 2021. They found that the prevalence of OUD among these adults is higher in counties with more place-level social vulnerability (e.g., socioeconomic disadvantage, high housing cost burden).

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Multiple Shots To Understanding Gun Violence, Lexi Gill

USF Tampa Graduate Theses and Dissertations

Gun violence is a ubiquitous issue across the United States, and recently, gun violence surpassed the previously recorded highest rates. Each year, tens of thousands of individuals lose their lives to gun-related violence. Gun violence is the leading cause of death among youth and disparately impacts young Black men. Some suggest gun violence is a social contagion that transmits from one individual to another and circulates through certain communities, suggesting gun violence can be “cured” with the appropriate treatment. Despite the proliferation of gun violence, current research on gun violence is underdeveloped. It is imperative to assess gun violence from …

The Myths Of Plato: Socratic Kenosis And The Call Of Beauty, Daniel Edward Shirley

Master of Arts in Classical Studies

The myths of Plato have been inordinately subordinated to the “intellect” of Plato since the eighteen-thirties. The ancient Christian tradition of interpreting stories and scriptures with symbolic understanding serves as a potentially primary hermeneutical pattern that could correct the modern tendency of subconscious materialism. To restore the Platonic myths, there are two foundational arguments to be made about the myths. The first is that these myths are kenotic in function. Observing the Socratic call to self-emptying, especially in the cosmological image of the World Axis, challenges modern assumptions concerning the second goodness of Platonic myth. The second argument is the …