Digital Commons Network^™

Hepatocellular Carcinoma Screening In A Contemporary Cohort Of At-Risk Patients, Nabihah Tayob, Vincent Merrill, Daniel Q Huang, Ju Dong Yang, Anand V Kulkarni, Fasiha Kanwal, Jorge Marrero, Neehar Parikh, Amit G Singal

Faculty, Staff and Students Publications

IMPORTANCE: Cohort studies demonstrating an association of hepatocellular carcinoma (HCC) screening with reduced mortality are prone to lead-time and length-time biases.

OBJECTIVE: To characterize the clinical benefits of HCC screening, adjusting for lead-time and length-time biases, in a diverse, contemporary cohort of at-risk patients.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study of patients with HCC was conducted between January 2008 and December 2022 at 2 large US health systems. Data analysis was performed from September to November 2023.

MAIN OUTCOMES AND MEASURES: The primary outcome was screen-detected HCC, defined by abnormal screening-intent abdominal imaging or α-fetoprotein level within 6 …

Deep-Learning-Based Image Super-Resolution Of An End-Expandable Optical Fiber Probe For Application In Esophageal Cancer Diagnostics, Richa Shukla, Shaleen Vasavada, Sharmila Anandasabapathy, Mark A Anastasio, Elena Petrova

Faculty, Staff and Students Publications

SIGNIFICANCE: Endoscopic screening for esophageal cancer (EC) may enable early cancer diagnosis and treatment. While optical microendoscopic technology has shown promise in improving specificity, the limited field of view (

AIM: To improve the efficiency of endoscopic screening, we propose a novel concept of end-expandable endoscopic optical fiber probe for larger field of visualization and for the first time evaluate a deep-learning-based image super-resolution (DL-SR) method to overcome the issue of limited sampling capability.

APPROACH: To demonstrate feasibility of the end-expandable optical fiber probe, DL-SR was applied on simulated low-resolution microendoscopic images to generate super-resolved (SR) ones. Varying the degradation …

Mindful Movements Matter: Differentiating Active Body Movements In Underprivileged Students’ Learning Of Physics Concepts, Seokmin Kang, Mingtsan Lu, John B. Black, Sungyeun Kim

Teaching and Learning Faculty Publications

Background

The theory of embodied cognition claims that body interaction with the environment change how we think and constitute cognition. Accordingly, active learning enriches learning experiences which in turn lead to better learning.

Purpose

Although learning by moving one’s body is often regarded as active learning, not all body movements lead to better learning. To investigate the influence of different levels of body movements on learning, we developed embodied learning activities and implemented in elementary afterschool program.

Sample

Twenty-seven fifth graders (12 girls, 15 boys) for Study 1 and forty-eight fifth graders (28 girls, 20 boys) for Study 2 were …

Increased Frequency Of Chd1 Deletions In Prostate Cancers Of African American Men Is Associated With Rapid Disease Progression Without Inducing Homologous Recombination Deficiency, Hua Li, Pranshu Sahgal, Jia Zhou, Zsofia Sztupinszki, Denise Young, Darryl Nuosome, Claire Kuo, Jiji Jiang, Yongmei Chen, Reinhard Ebner, Isabell Sesterhenn, Joel Moncur, Gregory Chesnut, Gyorgy Petrovics, Gregory T Klus, Gábor Valcz, Pier Nuzzo, Dezso Ribli, Judit Börcsök, Aurél Prósz, Marcin Krzystanek, Thomas Ried, Dávid Szüts, Kinza Rizwan, Salma Kaochar, Shailja Pathania, Alan D'Andrea, István Csabai, Shib Srivastava, Matthew Freedman, Albert Dobi, Sandor Spisak

Faculty, Staff and Students Publications

We analyzed genomic data derived from the prostate cancer of African and European American men in order to identify differences that may contribute to racial disparity of outcome and that could also define novel therapeutic strategies.

In addition to analyzing patient derived next generation sequencing data, we performed FISH based confirmatory studies of Chromodomain helicase DNA-binding protein 1 (CHD1) loss on prostate cancer tissue microarrays. We created CRISPR edited, CHD1 deficient prostate cancer cell lines for genomic, drug sensitivity and functional homologous recombination (HR) activity analysis.

We found that subclonal deletion of CHD1 is nearly three times as …

Novel Methods For The Remote Investigation Of Emerging Substances: Application To Kratom, Kirsten E Smith, Jeffrey D Feldman, Kelly E Dunn, Christopher R Mccurdy, Oliver Grundmann, Albert Garcia-Romeu, Leigh V Panlilio, Jeffrey M Rogers, Abhisheak Sharma, Salma Pont-Fernandez, Marina Kheyfets, David H Epstein

Faculty, Staff and Students Publications

The botanical product commonly called "kratom" is still relatively novel to the United States. Like other natural products marketed as supplements, kratom is highly variable, both in terms of the alkaloids naturally occurring in kratom leaves and in terms of processing and formulation. Kratom products sold in the United States are not well-characterized, nor are daily use patterns among regular users. Surveys and case reports have comprised most of the literature on kratom use among humans. To advance our understanding of real-world kratom use, we developed a protocol for the remote study of regular kratom-using adults in the United States. …

Brandeisian Banking, Kathryn Judge

Faculty Scholarship

Banking law shapes the structure of the banking system, which in turn shapes the structure of the economy. One of the most significant ways that banking law in the United States traditionally sought to promote Brandeisian values of stability and decentralization was through a combination of carrots and sticks that enabled small banks across the country to thrive. To see this requires a richer understanding of Brandeis as someone who valued not just atomistic competition but also small business and broad flourishing. It also requires a deeper understanding of the ways different parts of banking law worked together during the …

Racing Dobbs, Katherine M. Franke, Ria Tabacco Mar

Faculty Scholarship

In Dobbs v. Jackson Women's Health Organization, the U.S. Supreme Court reversed Roe v. Wade's limits on a state's ability to restrict, and indeed completely outlaw, abortion. The case raises fundamentally important questions about rights to reproductive autonomy, bodily integrity, sex equality, privacy, and health.

Upon closer examination, Dobbs is also about race and the nation's racial history, as the two papers published here argue. In Dreding Dobbs, Professor Katherine Franke suggests that Dobbs should be read alongside the Supreme Court's 1857 decision in Dred Scott v. Sandford, in which the Court held that Black people-even free or freed Black …

A Double-Blind, Randomized Controlled Study Of The Effects Of Celecoxib On Clinical Symptoms And Cognitive Impairment In Patients With Drug-Naïve First Episode Schizophrenia: Pharmacogenetic Impact Of Cyclooxygenase-2 Functional Polymorphisms, Li Wang, Thomas R Kosten, Xiang-Yang Zhang

Faculty, Staff and Students Publications

Chronic low-grade peripheral and central nervous system inflammation may have a role in the pathogenesis of schizophrenia (SCZ). Inhibition of cyclooxygenase-2 (COX2), the arachidonic acid pathway, may inhibit cytokine responses and minimize inflammation. In this study, we added the COX2 inhibitor celecoxib to risperidone monotherapy to examine its efficacy on clinical symptoms and cognitive deficits in drug-naïve first episode (DNFE) SCZ patients. First, we genotyped two polymorphisms (rs5275 and rs689466) in the COX-2 gene in a case-control study of 353 SCZ patients and 422 healthy controls. Ninety patients participated in a 12-week, double-blind, randomized, placebo-controlled trial of celecoxib 400 mg/day. …

Culture Education Program To Improve Work Culture In Healthcare, Ngufor Fube Divine

Electronic Theses and Dissertations

Abstract

This study investigated the efficacy of a culture educational intervention program in addressing toxic work culture within healthcare settings. The prevalence of toxic work environments in healthcare has been linked to adverse outcomes for both employees and patients. The purpose of this study was to assess the impact of a targeted culture educational intervention on shifting organizational culture towards more positive dimensions, specifically focusing on Clan, Adhocracy, Market, and Hierarchy cultures. Utilizing a quantitative quasi-experimental design, this study employed repeated measures to assess participants' perceptions of organizational culture before, immediately after, and preferred following the intervention. The sample consisted …

Empowerment In Patriarchy: A Phenomenological Study Of Working Mothers In The Church Of Jesus Christ Of Latter-Day Saints, Michael Snapp

Electronic Theses and Dissertations

The purpose of this phenomenological study was to explore systems of empowerment and support for female members of a patriarchal society who work full-time outside of the home. Specific to this study are the lived experiences of female members of The Church of Jesus-Christ of Latter-day Saints (the Church) who are married, have at least one child at home, and have full-time employment outside the home, and the systems of support or empowerment that have been in place, or that they wish had been in place. Ten participants described their experiences as they related to working full-time outside the home, …

Investigating Essential Oils, Natural Compounds, And Marine Based Rumen Buffers As Feed Additives For Enteric Methane Mitigation And Improved Ruminant Productivity, Ian Hodge

Theses

Ruminant dietary additives were investigated for enteric methane (CH4) mitigation and their effects on rumen fermentation characteristics during both in vitro and in vivo supplementation trials. A meta-analysis of the peer reviewed published literature was initially performed to establish the state of the art in the field and allowed benchmarking of the performance of the dietary additives screened during the project. Investigated feed additives included garlic oil (GO), nitrate, Ascophyllum nodosum (AN), Asparagopsis (ASP), Lactobacillus plantarum (LAB), calcareous marine algae (CMA), chitosan (CHI), essential oils (EO) and 3-nitrooxypropanol (3-NOP). The development of an in vitro screening method to evaluate the …

A Mobile Health Transitional Care Intervention Delivered By Nurses Improves Postdischarge Outcomes Of Caregivers Of Patients With Traumatic Brain Injury: A Randomized Controlled Trial, Amelia Ganefianty, Praneed Songwathana, Jintana Damkliang, Akhmad Imron, Jos M. Latour

School of Nursing and Midwifery

OBJECTIVE: Caring for patients with traumatic brain injury (TBI) during the transition from hospital to home can be psychologically challenging to caregivers. This study aimed to assess the effectiveness of a novel mobile health (m-health) transitional care intervention to reduce stress and burden of caregivers of patients with TBI and to reduce readmissions.

METHODS: A randomized controlled trial was conducted with 74 caregivers of adult patients with moderate or severe TBI admitted to a referral hospital in Indonesia. An m-health application for Android mobile phones was designed including education and information for caregivers. The application included an online chat feature …

A Pilot Intervention For Adolescent Adoptees: The Interoception Curriculum, Francie X. Bailey

Capstone Projects

This pilot study sought to evaluate the efficacy of Mahler’s (2019) Interoception Curriculum on increasing emotional regulation and interoceptive awareness among adolescent adoptees. A pre - posttest design was employed to assess changes in emotional regulation and interoceptive awareness following a condensed, 10 - week version of the curriculum. Six participants, and their respective parent, completed pretest and posttest assessments following the completion of the weekly intervention. Results demonstrated minimal improvements in both parent and adolescent perceived emotional regulation competency but significant improvement in adolescents’ ability to notice and attend to their bodily sensations, listen to their body cues, and …

Program Development For Group Interventions Targeting Loneliness In Older Adults, Antoinette Cave

Capstone Projects

The topic of loneliness is complex and subjective in nature, and treatment of the condition requires the client-centered approach that occupational therapy encompasses within its scope of practice. Using an occupation-based, mental health approach to develop the program, weekly focus groups were created based on participant-preferred activities to decrease loneliness among older adults at PACE InnovAge’s outpatient and assisted living locations in Thornton, Colorado. Education was provided to participants and staff throughout the 14-week experience. Further training and sustainability efforts were created and distributed among participants and staff at the end of the experience through an occupation-based handout with external …

Trauma Informed Care Resources For Foster And Adoptive Families, Nitasha Cooper

Capstone Projects

Trauma informed care is meeting the needs of children who have undergone trauma by addressing the direct impact caused by the trauma the child experienced. My objectives looked to assist parents in the carryover from the occupational therapy clinic to home by providing videos on techniques to address behaviors occurring in and out of the home and building a connected relationship between child and caregiver as well as resources such as books for children and caregivers; podcasts; social media personnel; support groups; and a respite list. These objectives resulted in a plethora of resources for caregivers and families to access …

Development Of Occupation-Based And Trauma-Informed Care Resources To Promote Successful Reentry Following Release From Prison, Anna Burch

Capstone Projects

This 14-week capstone project focused on program development and education to establish occupational therapy-based resources into the Region 4 OS Reentry program through Michigan Department of correction (MDOC). The project was based out of Kent County Parole Office with the target population focusing on people who are actively on parole. Region 4 OS Reentry provides those on parole with many resources including bus cards, transitional housing, food vouchers, clothing/self-care assistance, trauma counseling and more. The purpose of this project was to utilize an occupational therapy lens to create resources revolving around ADL/IADLs, mental health, connecting the program with other community …

Student Comprehension Of Addressing Acote Standards Related To Fieldwork Educators And Level I Fieldwork Sites, Baileigh Grabow

Capstone Projects

Accreditation Council of Occupational Therapy Education (ACOTE) standards are the rules and procedures occupational therapy academic programs across the country are mandated to follow and uphold (ACOTE, 2018). The standards are the framework to ensure quality education of the same rigor across OT/OTA programs preparing the future practitioners of occupational therapy. The ACOTE Standards (2018) have an “A” section related the resources, faculty experience, public policies, curriculum framework, and strategic plan requirements, a “B” section related to didactic program content requirements, a “C” section for fieldwork requirements, and a “D” section related to capstone requirements.

The purpose of this doctoral …

Inclusive Yoga Programming For Children With Diverse Needs, Allison H. Hansel

Capstone Projects

Limited research exists to support the use of yoga as an occupational therapy intervention for children with disabilities. In the studies that are available, yoga is primarily used to target children with autism spectrum disorder (ASD). Currently there is no research available that explores use of yoga in a group of children with a variety of disabilities and diagnoses. The aim of my doctoral capstone experience was to design and implement an inclusive yoga group for children with diverse needs. Objectives were created to guide this capstone project such as creating intake forms, pre/post surveys, weekly yoga curriculum and weekly …

Enhancing Self-Regulation Skills With The Zones Of Regulation, Sara Hayes

Capstone Projects

It has been highlighted that children with Autism Spectrum Disorder (ASD), Cognitive Impairments, Emotional Impairments, and other Sensory Processing Disorders. often lack the ability to self-regulate appropriately. Self-regulation is defined as the ability to control one’s emotions and behaviors, get along with others and engage in learning. Self-regulation helps children learn effectively, obtain, and maintain relationships, and communicate appropriately. A tool proven to teach and implement appropriate self-regulation is Leah Kupyers’ Zones of Regulation curriculum. The purpose of this literature review is to analyze the potential for OT involvement in the implementation of the Zones of Regulation curriculum within the …

The Development Of An 8-Week Neurodiversity-Affirming Caregiver Co-Regulation Coaching Program., Carissa Heestand

Capstone Projects

The realm of pediatric care is witnessing the rapid emergence of two innovative practices centered on nurturing safety within a child's nervous system. This program development endeavors to synergize these practices to optimize occupational balance within the familial unit. The first pioneering approach involves Neurodiversity (ND) affirming care, which is seamlessly integrated into therapy sessions. Here, therapists honor and embrace the diverse nature of each child's brain, while acknowledging and celebrating their unique abilities. The second innovative practice involves caregiver coaching sessions, with a primary focus on educating caregivers about co-regulation techniques. Previous research has highlighted the efficacy of such …

The Role Of Occupational Therapy In Transition Programs For High School Students With Disabilities, Kara Hutchison

Capstone Projects

Students with disabilities frequently experience a gap in services as they grow older and after exiting the public education system. During school, students have Individualized Education Plans (IEPs) to support their education, but once they graduate, the services they were receiving expire. Occupational therapy is under- utilized in transition planning for students after graduating high school and entering adulthood. The purpose of this DCE was program development and advocacy with the Project SEARCH transition program while exploring the role of occupational therapy has in transition planning for high school students with disabilities. The goal of this project was to improve …

The Integration Of Occupational Therapy In Transition Programs To Improve Outcomes For Students, Morgan Jagiela

Capstone Projects

Numerous studies exist depicting the benefit and efficacy of an occupational therapy (OT) presence within post-secondary transition programs. Both transition programs and occupational therapists aim to help students with disabilities improve independent living skills, vocational skills, and social/communication skills, so they may live functional adult lives with as few supports as possible. Despite this success and the overlap in scope, OT is rarely found in transition programs. The purpose of this doctoral capstone experience (DCE) was to develop a program that would implement occupational therapy into the Empower U transition program. Through the creation and completion of objectives, success and …

Friends At Work: Creating A Peer-To-Peer Program For Individuals With Disabilities In The Workplace, Claire Johnson

Capstone Projects

Students with disabilities face social isolation, loneliness, mental health conditions, and unemployment rates at a disproportionately high rate compared to their typically developing peers (Choiseul-Praslin et al., 2019). Peer support programs and transition to work organizations have the ability to combat these factors. The following Doctoral Capstone Experience depicts the development and implementation of a peer-to-peer program within a transition to work program to increase social participation amongst transitional students with disabilities. The program was implemented at Project SEARCH at Corewell Health Beaumont Troy Hospital. Additionally, this project attempts to quantitatively qualify the effectiveness of the Project SEARCH program in …

Improving The Care Of Individuals With Neurogenic Bowel And Bladder Dysfunction In An Inpatient Rehabilitation Setting, Brooke Loucks

Capstone Projects

Neurogenic bladder and bowel dysfunction can lead to serious health complications and negatively impacts one’s mental health and quality of life (Kurze et al., 2022l; Borsh et al., 2019 ). Despite the abundance of research on the topic concerning the spinal cord injury population, there is limited generalization to other neurologic conditions with similar presentation. There is also a need for practical implementation and clinical guidelines in health care systems (Kurze et al., 2022l; Borsh et al., 2019). Toileting is one of the main activities of daily living listed in the Occupational Therapy Practice Framework ( AOTA, 2020) yet the …

Occupational Therapy Health & Wellness Promotion For Adults Living With Intellectual/Developmental Disabilities, Sydni Rodriguez

Capstone Projects

Based on educational principles and program development, this occupational therapy doctoral capstone experience (DCE) was centered on addressing the health and wellness needs of adults living with intellectual/developmental disabilities (I/DD) at Self-Help Alternative Living Opportunities Michigan (SHALOM), a Christian non-profit organization. Research has shown that adults living with I/DD have an increased chance of having health complications related to health disparities when compared to the general population of adults. Occupational therapists have a profound role in health and wellness as it relates to access and engagement in daily occupations. This DCE was accomplished through development of a recurrent monthly walking …

Occupational Therapy's Role In Post-Secondary Transition Programing For Young Adults With Disabilities, Mallory Rubley

Capstone Projects

Post-secondary transition programs for young adults with intellectual or developmental disabilities (IDD) are designed to support young adults with IDD in areas of independent living, academics, relationships, financial management, health and safety, and employment. All of which are within the scope of occupational therapy (OT). Within the limited post-secondary transition programs that exist for these young adults, OT is rarely included as a provided service, creating an unintentional disadvantage to the students and clients. The purpose of this Doctoral Capstone Experience (DCE) was program development and advocacy for the role of occupational therapy within Ready for Life (RFL), a post-secondary …

Implementation Of A Life Skills Program With Houseless Youth, Stephanie Velasco

Capstone Projects

The goal of my capstone project was to use occupational therapy knowledge and processes to integrate life skills training into a pre-existing program of services at a not-for-profit organization that helps youth overcome being houseless on Oahu, Hawaii. Occupational therapy as a profession helps individuals to engage in everyday meaningful activities as independently as possible. The scope of occupational therapy includes education and practice of life skills. Life skills are practical abilities and behaviors that allow individuals to effectively meet the demands and challenges of everyday life. Examples of these are knowledge of food and nutrition, meal preparation, home cleanliness …

Recollection-Based Occupational Therapy: An Activities Program For Catholic Dominican Sisters With Dementia, Alyssa J. Visockis

Capstone Projects

Recollection-based occupational therapy is a nonpharmacological approach to dementia, involving five categories of activities: horticultural, physical, art, musical, and instrumental activities of daily living (IADLs). The purpose of this approach is to incorporate memories of a person’s childhood, adulthood, and older adulthood before dementia in activities. Furthermore, the Grand Rapids Catholic Dominican sisters at Aquinata Hall needed a method to gather psychosocial history on their residents as well as new activity programming on the dementia- care unit that had meaningful purpose. Therefore, during this capstone experience, a psychosocial history assessment was created and conducted with the sisters. Using the results …

Support Group Development And Implementation For Parents With Disabilities, Jessica Zydorczyk

Capstone Projects

The focus of this capstone project was to develop a peer-to-peer support group open to any parent or caregiver with a disability navigating the challenges of pregnancy and parenthood. Occupational therapy can have a large impact on the population of individuals parenting with a disability with increased awareness and understanding of their needs. Friendship, community, resource access, and awareness were all needs addressed with the development of the parent support group. The objectives set to be achieved during the 14-week experience included conducting extensive research on the disabled parenting experiences of day-to-day life, developing of handouts and resource collection on …

Implementation Of A Bilingual Feeding Program For Hispanic Children With Autism Spectrum Disorder, Sarah Aguilar

Capstone Projects

Feeding is an important occupation that contributes to a child’s physical, emotional, and social development and is also influenced by cultural and environmental factors, (Korth & Maune, 2020). In individuals with developmental delays, specifically autism spectrum disorder (ASD), feeding difficulties have been reported in as many as 75% of children (Nygren et al., 2021). These difficulties often result in increased feelings of anxiety experienced by the child and caregiver. Limited information exists on the impact of these on minority populations, such as Spanish speaking families that face many challenges when accessing healthcare services like language and cultural barriers. Similarly, group …