Digital Commons Network^™

Ensemble-Based Mutational Profiling And Network Analysis Of The Sars-Cov-2 Spike Omicron Xbb Lineages For Interactions With The Ace2 Receptor And Antibodies: Cooperation Of Binding Hotspots In Mediating Epistatic Couplings Underlies Binding Mechanism And Immune Escape, Nishank Raisinghani, Mohammed Alshahrani, Grace Gupta, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this study, we performed a computational study of binding mechanisms for the SARS-CoV-2 spike Omicron XBB lineages with the host cell receptor ACE2 and a panel of diverse class one antibodies. The central objective of this investigation was to examine the molecular factors underlying epistatic couplings among convergent evolution hotspots that enable optimal balancing of ACE2 binding and antibody evasion for Omicron variants BA.1, BA2, BA.3, BA.4/BA.5, BQ.1.1, XBB.1, XBB.1.5, and XBB.1.5 + L455F/F456L. By combining evolutionary analysis, molecular dynamics simulations, and ensemble-based mutational scanning of spike protein residues in complexes with ACE2, we identified structural stability and binding …

Collapsing Education And Teacher Rights In South Korea: Exploring Korean Teacher, Student, And Parent Relationships, Briyanna Moore

Honors Projects

South Korea has one of the best education systems, as Korean students tend to excel in multiple academic areas in comparison to the national averages of other countries (WENR, 2018). However, due to the high academic and societal pressures placed on Korean students to succeed in school, South Korean teachers have become increasingly overwhelmed with handling parent and student demands. Due to the updated Korean Child Welfare Act (2014), Korean teachers now face claims of child abuse from parents either for reprimanding students who were initially combative in class, or for denying parents’ request for after school extracurricular services for …

Miniature Battery-Free Epidural Cortical Stimulators, Chunfeng Tan

Faculty, Staff and Student Publications

Miniaturized neuromodulation systems could improve the safety and reduce the invasiveness of bioelectronic neuromodulation. However, as implantable bioelectronic devices are made smaller, it becomes difficult to store enough power for long-term operation in batteries. Here, we present a battery-free epidural cortical stimulator that is only 9 millimeters in width yet can safely receive enough wireless power using magnetoelectric antennas to deliver 14.5-volt stimulation bursts, which enables it to stimulate cortical activity on-demand through the dura. The device has digitally programmable stimulation output and centimeter-scale alignment tolerances when powered by an external transmitter. We demonstrate that this device has enough power …

Serum Neuroactive Metabolites Of The Tryptophan Pathway In Patients With Acute Phase Of Affective Disorders, Yanfang Zhou, Baopeng Tian, Wei Li, Xingguang Luo, Li Tian, L Elliot Hong, Chiang-Shan R Li, Yunlong Tan

Faculty, Staff and Student Publications

BACKGROUND: Many studies showed disrupted tryptophan metabolism in patients with affective disorders. The aims of this study were to explore the differences in the metabolites of tryptophan pathway (TP) and the relationships between TP metabolites and clinical symptoms, therapeutic effect in patients with bipolar disorder with acute manic episode (BD-M), depressive episode (BD-D) and major depressive disorder (MDD).

METHODS: Patients with BD-M (n=52) and BD-D (n=39), MDD (n=48) and healthy controls (HCs, n=49) were enrolled. The serum neuroactive metabolites levels of the TP were measured by liquid chromatography-tandem mass spectrometry. Hamilton Depression Scale-17 item (HAMD-17) and Young Mania Rating Scale …

Occentatia: Community And Escapism Through Queer World-Building, Ian Cooper

Theses and Dissertations

55 PagesOccentatia is an investigation into queer world-building, inspired by fantasy games, electronic media, and the culture of the ‘90s and early 2000’s. Built by a diverse creative team of 22 artists, audiences and readers are invited to explore the medieval-Gothic world of Occentatia through drawing and illustration, video and audio, sculpture, and installation This supportive statement guides readers through inspirations, socially engaged art, insight into characters, and the development of fantastical narratives. I hope to provide clarity to my practice, displaying the need for more research on the role fantasy and gaming play in understanding queer identities, aesthetics, and …

An Explanatory Sequential Mixed Methods Study To Understand Stakeholder Collaboration In Precision Medicine, Worlanyo Sosu-Sedzorme

Doctor of Philosophy in Translational Health Sciences Dissertations

Background: Precision medicine is a promising approach to healthcare that can improve the diagnosis, treatment, and prevention of various health conditions. However, its implementation into clinical practice is complex and requires effective collaboration among multiple stakeholders. Unfortunately, the current state of stakeholder collaboration in precision medicine is poorly understood.

Objective: This study explored stakeholder collaboration in precision medicine to identify barriers and facilitators and propose recommendations for effective collaboration.

Study participants: The study recruited thirty-eight individuals involved in precision medicine, including providers, patients or guardians, administrative personnel, and researchers from multiple healthcare organizations, mainly in the mid-Atlantic …

A New Vicarious Technique For Radiometric And Spatial Calibration Of Drone-Based Multispectral And Hyperspectral Imaging Systems, David N. Conran

Theses

A new technology (convex mirrors) used for radiometric and spatial characterization of remote sensing imaging systems has demonstrated equal, but unique results when compared to Lambertian targets for vicarious calibration. Using convex mirrors to characterize the radiometric and spatial response of hyperspectral and multispectral imaging systems has yet to be thoroughly investigated for drone-based platforms. When imaged, a convex mirror produces a known radiant intensity source that can characterizes the radiometric and spatial performance of an imaging system. The simultaneous assessment supports a unique understanding of the hyperspectral and multispectral instrument’s response for vicarious characterization. Assessing a new technique for …

Perceived Recovery States And Physical Fitness In Reserve Officers’ Training Corps Cadets, Lianne Emanuel, Jessie Hirsch, James Bodendorf, Amy Loin, Gregory Ioannides, Aliya Catanzarita, Tarek Harhash, Joseph Schnatter, Isaac Stein, Sean Kane, Julianne Rung, Katie Sell

International Journal of Exercise Science: Conference Proceedings

Reserve Officers’ Training Corps (ROTC) cadets are challenged mentally, emotionally, and physically with the physical fitness requirements (e.g., Army Combat Fitness Test or ACFT) required within their military science curriculum. Common physical fitness tests such as those for strength, power, and balance can provide insight into the recovery and readiness status of tactical athletes. PURPOSE: The purpose of this study was to explore the relationship between scores on the Short Recovery and Stress Scale (SRSS) and performance on a physical fitness test battery assessing balance, mobility, body composition, muscular strength, and power in collegiate ROTC cadets. METHODS: Seventeen ROTC cadets …

Effects Of Electrical Exercise On Self-Reported Depression And Quality Of Life In Those With Spinal Cord Injury, Aj Barber, Eric Heidorn, John Mcdaniel, Cody S. Dulaney

International Journal of Exercise Science: Conference Proceedings

One of the most common psychological disorders that occur as a result of spinal cord injury (SCI) is depression along with reductions in quality of life. Moreover, depression is correlated with quality of life. It is increasingly apparent that exercise offers an accessible and non-pharmacological intervention to ease depressive symptoms and improve quality of life. Unfortunately, access to meaningful exercise options remains challenging to those with mobility impairments such as those seen with SCI. PURPOSE: The purpose of this study was to assess the chronic engagement of home-based electrical stimulation exercise (ESE) on self-reported depression and quality of life …

Effects Of Electrical Exercise And Affect On Self-Reported Anxiety In Those With Spinal Cord Injury, John Zimmerman, Eric Heidorn, John Mcdaniel, Cody S. Dulaney

International Journal of Exercise Science: Conference Proceedings

Those who have incurred a spinal cord injury (SCI) have severe and immediate changes to their lifestyle. Those with SCI have reported reduced levels of positive affect and no change in negative affect compared to controls. Also, those with SCI may have reduced opportunities for engaging in meaningful exercise either due to mobility or equipment access limitations. PURPOSE: The purpose of this study was to assess the chronic engagement of home-based electrical stimulation exercise (ESE) on self-reported anxiety and positive and negative affect. METHODS: 9 individuals with ASIA A or B SCI were recruited for this study. Participants …

Effects Of Acute Exercise And Socialization On Mood And Cognition, Justin E. English, Kristine Sabo, Jane Ekhtman, Emmanuel Egwuonwu, Andy Fernandez, Douglas J. Oberlin

International Journal of Exercise Science: Conference Proceedings

How do social interactions, exercise, or a combination of both affect a person’s mood and cognition? Research has shown benefits of aerobic exercise, for example, a recent study showed that group fitness classes decreased perceived stress among a group of medical students. However, it didn’t explain if that was because of the socialization that occurs in a group fitness setting or if it was because of the physical activity. PURPOSE: The purpose of this study was to compare how aerobic exercise and socialization contribute to acute improvements in mood and cognition. METHODS: Participants, recruited from CUNY campuses (n=19), …

Artificial Sociality, Simone Natale, Iliana Depounti

Human-Machine Communication

This article proposes the notion of Artificial Sociality to describe communicative AI technologies that create the impression of social behavior. Existing tools that activate Artificial Sociality include, among others, Large Language Models (LLMs) such as ChatGPT, voice assistants, virtual influencers, socialbots and companion chatbots such as Replika. The article highlights three key issues that are likely to shape present and future debates about these technologies, as well as design practices and regulation efforts: the modelling of human sociality that foregrounds it, the problem of deception and the issue of control from the part of the users. Ethical, social and cultural …

The Perturbing Mediatization Of Voice-Based Virtual Assistants: The Case Of Alexa, Leopoldina Fortunati, Autumn P. Edwards, Chad Edwards

Human-Machine Communication

This study examines the role of voice-based assistants (VBAs), specifically Alexa, in the mediatization paradigm framework. The authors hypothesize that emerging technologies such as chatbots and VBAs intensify the process of online meta-reintermediation of news. Three research questions were investigated through a questionnaire administered to 655 university students in the US and Italy: Do participants try to get news from Alexa? Are participants aware that VBAs represent a case of meta-reintermediation of news? Does Alexa contribute to the potential hybridization of news, information, and knowledge? The analysis of 451 open-ended answers showed that only a fraction of participants searches for …

Communicative Ai And Techno-Semiotic Mediatization: Understanding The Communicative Role Of The Machine, Göran Bolin

Human-Machine Communication

Mediatization discourse has so far mainly been centered on media from institutional or social-constructionist approaches. The technological developments within communications industries coupled with the wider societal process of datafication might, however, beg for dusting off the smaller, although the long-time existing, technological approach to mediatization as a complement to the two other approaches, in order to understand aspects of automation and human-machine communication. This theoretical article explores how existing mediatization approaches can refocus to include lessons learned from human-machine communication. The first section accounts for the main mediatization approaches. The second section discusses debates on communication, artificiality, and meaning-making. The …

Quacking For Noggin: Farm Animal Assisted Therapy For The Traumatic Brain Injury Survivors, Alex Sargsyan

Epsilon Sigma at-Large Research Conference

The Aim

The aim of this study was to examine the effects of Animal Assisted Therapies with Farm Animals (AATF) with domesticated ducks on depression, anxiety, and self-efficacy in patients with traumatic brain injury (TBI) . Furthermore, the following hypothesis was tested:

Engaging in AATF with domesticated ducks will be associated with decrease in depression, anxiety, and an increase in self-efficacy.

Methods

The study examined the effects of AATF on anxiety and depression among patients with TBI. Time series quasi-experimental design structure was utilized. At the beginning of the study participants received Hospital Anxiety and Depression Survey (HADS) and General …

Optimal Control Of Coefficients For The Second Order Parabolic Free Boundary Problems, Ali Hagverdiyev

Mathematics Colloquium Series

In this talk I will discuss Inverse Stefan type free boundary problem for the second order parabolic equation arising for instance, in modeling of laser ablation of biomedical tissues, where the information on the coefficients, heat flux on the fixed boundary, and density of heat sources are missing and must be found along with the temperature and free boundary. New PDE constrained optimal control framework is employed, where the missing data and the free boundary are components of the control vector, and optimality criteria are based on the final moment measurement of the temperature and position of the free boundary. …

Health Literacy And Diabetes Outcomes In Adults With Type 2 Diabetes In Southwest Virginia, Casandra Reyes Arellano

Epsilon Sigma at-Large Research Conference

Purpose: To determine if a quality improvement project involving individualized, one-on-one Diabetes education will improve health literacy and Diabetes outcomes in adults with Type 2 Diabetes in a rural primary care clinic. Diabetes is a chronic condition affecting the United States with 9.6% of Virginia’s population living with Diabetes.

Aims: To improve patient’s Diabetes literacy scores, BMI, and Hemoglobin A1c levels through Diabetes education.

Processes: There are pre- and post-education phases. Data to be collected at the end of both phases consist of DNT15 scores, BMI, and A1c. In the pre-education phase, BMI was obtained, DNT15 was administered, and Diabetes …

Phun With Phages: Discovering Novel Bacteriophages In The Soil, Julia Kutz, Ryan Dodds, Logan Dykstra, Taylor M. Rentschler, Emma Steinhardt, Megan Vangarven, Jacie Vanderwaal, Shayler Vangelder, Byron Noordewier, Sara S. Tolsma

Celebration of Research

We used three bacterial hosts: Mycobacterium smegmatis, Microbacterium foliorum, and Gordonia terrae, to isolate novel bacteriophages from soil samples. We named these phages, created high titer lysates, and purified their DNA genomes. We have archived the high titer lysates at Northwestern College and the University of Pittsburgh. The genomes of three of our phages were sequences at the University of Pittsburgh and we will be sequencing the remaining genomes this summer. Additionally, we are planning to image our phages with transmission electron microscopy at the University of Iowa or Nebraska yet this semester.

Association Between Carpal Tunnel Syndrome And Amyloid Heart Disease May Assist With Early Detection And Reduced Morbidity And Mortality, Kayla Nachbar, Nicole Kirk, Jaclyn Freese

Celebration of Research

Carpal tunnel syndrome may help identify more systemic issues than previously thought. Multiple research studies establish an association between carpal tunnel syndrome and heart disease, most specifically cardiac amyloidosis. This link is of importance as it requires alternative treatment choices to extend life expectancy for those diagnosed with the disease. Based on this analysis of multiple studies, there may be an indication for a screening criterion in those with carpal tunnel syndrome to identify a previously illusive disease before it progresses. History and certain clinical features may add to the utility of this finding to be applied as a screening …

Prepplates: Meal Prep For Busy Lives, Alec Coronado Garcia, Luc Roelofs, Kade Fey

Celebration of Research

PrepPlates is an innovative meal idea based in Sioux County. Our purpose is clear: to transform the way people approach mealtime by providing not only nourishment but also a comprehensive dining experience suited to their preferences and lifestyles. Our business venture aims to revolutionize the meal kit industry by providing convenient, affordable, and high-quality meal solutions tailored to the preferences and lifestyles of our demographic. Through research and strategic planning, PrepPlates emerges as a beacon of innovation in the competitive landscape of meal preparation services. Rooted in a comprehensive understanding of demographic and market trends, our business model is tuned …

Metabolic Characterization Of Porcine Hepatocytes, Sophie Swart, Ainslie Robinson, Daiki Jonouchi, Marcus Blankespoor, Kip Cullinan, Zachary Varpness, Ryan Schulze

Celebration of Research

No abstract provided.

H(Hydrogen)-Alpha Spectral Imaging Of Z>5 Quasars, Pratik Paudel, Mari Hirota, Hyunsung Jun

Celebration of Research

We aim to measure the H-alpha line excess over the photometric continuum for distant quasi-stellar radio objects, or quasars. Supermassive black holes grow in mass through accretion of stars or gas nearby, often outshining the total stellar light of the galaxies they reside in, for quasars. On the other hand, the structure of these active galactic nuclei are hard to resolve, where we often rely on the relationship in between different light emission regions to better understand the geometry and emission mechanisms. In this work, we measure the H-alpha luminosity of 44 quasars at z>5 (light coming from less …

Muscle Activation Frequency Relationship With Cost Of Transport At Increasing Walking Speed Reveals Interplay Of Both Active And Passive Dynamics, Grace Van Namen

Celebration of Research

The purpose of this study was to examine the correlation between metabolic cost and muscle activity, with a focus on frequency of EMG signals during walking at different speeds. The findings will be valuable in rehabilitating individuals who suffer from gait-related disorders. Nine participants were recruited. In the first session of data collection, each participant performed a ten-meter walk test determining their average walking speed. Using these average walking speeds, six more speeds were subsequently established during the second session. In the second session, subjects walked for four minutes at each of the six speeds while EMG data was collected …

The Impact Of Blood Flow Restriction On Heart Rate And Muscle Activation, Janaya Battles, Rajat Singh, Daniel Swier

Celebration of Research

Blood Flow Restriction (BFR) is a rehabilitation technique used in physical therapy to improve muscle growth in patients. The technique involves using blood cuffs on the limbs to occlude blood flow within the muscles, thus limiting the buildup of muscle growth inhibitors. The current literature provides information regarding these aspects but is limited in providing information regarding the impact of BFR on neural muscular coordination. Therefore, the purpose of this study was to determine how various pressure levels of the BFR cuffs can impact the muscle activation of the restrained muscles and heart rate. Our results have shown that a …

Deaths Of Despair In Rural Populations, Tirzah Wittenberg, Dr. Pam Hulstein

Celebration of Research

A literature review was conducted between August 2023-November 2023 to explore deaths of despair in rural and urban populations. The ten articles reviewed center around revealing the prevalence of substance abuse and suicide within different population densities. The purpose of examining this research is to create a foundation of understanding that can then be utilized when making changes on the micro and macro levels in access to health care resources. In this literature review, the prevalence of deaths of despair in rural populations is revealed, along with suggestions for future health care resource investments.

Perceived Severity Of Trauma: The Impact Of Gender And Exposure, Macy Hajek

Celebration of Research

The purpose of this study was to examine factors that may influence the perceived severity of traumatic events. Perceived severity scores were examined in a 2x2 factorial ANOVA with the factors of gender and trauma exposure. A qualitative measurement of the most feared trauma was also investigated. Participants were a convenience sample of 98 Northwestern College Students ranging from ages 17 to 22. Perceived severity scores and the most feared trauma were obtained using an adapted version of the Trauma History Questionnaire. A Trauma History Screener was used to divide participants into trauma exposure groups. It was hypothesized that females …

Interventions To Reduce Risk Of Perineal Tearing, Bailey Varpness, Kylie Lyman, Sandra Muyskens

Celebration of Research

Perineal tearing is one of the most common injuries that can be sustained during vaginal delivery, it can be physically and mentally debilitating for the mother to endure. Preventing this injury can lead to an easier healing process for the mother, allowing her to have a more impactful postpartum journey. There is debate as to whether warm compresses, perineal massage, and alternative birthing positions decrease the incidence of perineal tearing. This review of literature focuses on how these interventions work and if they are effective at decreasing the risk for perineal tearing during vaginal delivery.

A Shift Towards Informed Decision Making: Hormonal Contraception Versus Natural Cycle Tracking, Lauren Jurrens, Sydnee Isom, Deann Jelsma

Celebration of Research

Females participating in the wide array of birth control options are continuing to expand. With that, more females are expressing concerns about potential adverse drug reactions and side effects of hormonal birth control. While general side effects do occur, the risks for venous thromboembolism (VTE) vary depending on the hormone taken, and cancer risks are minimal to even nonexistent.^3,4,7,15 Yet, many females are turning to natural cycle tracking to avoid synthetic hormones, common side effects, and potential poor health outcomes. Both options can provide comparable efficacy when used appropriately. Therefore, providers must be knowledgeable in all contraception options to …

Ai In The Classroom, Shareef Zaid Arroyo

Andrews University Teaching and Learning Conference

No abstract provided.

Animal-Assisted Services And Occupational Therapy Within An Australian Context: A Survey Study, Jessica Hill, Carlie Driscoll, Kelly Pearse

People and Animals: The International Journal of Research and Practice

Introduction: The incorporation of animal-assisted services is an emerging field of occupational therapy. There remains varying levels of involvement and knowledge of what is involved in animal-assisted services among Australian occupational therapists. The profession of occupational therapy acknowledges that competence as a clinician requires appropriate education and knowledge guiding clinical decision making.

Research Question: This study aimed to explore the understanding and role of Australian occupational therapists including animal-assisted services in their practice, as well as the changes required to support future service delivery.

Methods: A cross sectional survey was conducted online. Participants were recruited through a digital mailing list, …