Digital Commons Network^™

Protein Sumoylation Promotes Camp-Independent Epac1 Activation, Wenli Yang, Fang C Mei, Wei Lin, Mark A White, Li Li, Yue Li, Sheng Pan, Xiaodong Cheng

Faculty, Staff and Student Publications

Protein SUMOylation is a prevalent stress-response posttranslational modification crucial for maintaining cellular homeostasis. Herein, we report that protein SUMOylation modulates cellular signaling mediated by cAMP, an ancient and universal stress-response second messenger. We identify K561 as a primary SUMOylation site in exchange protein directly activated by cAMP (EPAC1) via site-specific mapping of SUMOylation using mass spectrometry. Sequence and site-directed mutagenesis analyses reveal that a functional SUMO-interacting motif in EPAC1 is required for the binding of SUMO-conjugating enzyme UBC9, formation of EPAC1 nuclear condensate, and EPAC1 cellular SUMOylation. Heat shock-induced SUMO modification of EPAC1 promotes Rap1/2 activation in a cAMP-independent manner. …

Influence Of Knot Strength On The Mechanical Performance Of A Biodegradable Gillnet, Louis Le Gué, Esther Savina, Mael Arhant, Peter Davies, Nicolas Dumergue, Benoit Vincent

Faculty, Staff and Student Publications

Ghost fishing is a global issue that can be addressed using fishing gear materials that do not persist in the marine environment. However, for these alternatives to be widely adopted, they must meet the same mechanical specifications as current commercial materials while degrading without any negative impact. The objective of this study was to compare a conventional gillnet made of polyamide 6 (PA6) with an alternative made of poly(butylene succinate-co-adipate-co-terephthalate) (PBSAT) at three different scales: monofilament, knot, and net. While the PBSAT monofilament's strength was half that of the conventional PA6 net, knot and net losses were even more significant. …

Habit And The Potential For Actor Training With Immersive And Virtual Production Technology, John Matthews

School of Law, Humanities and Social Sciences

No abstract provided.

2024 July 4 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

How Household Economic Stress Matters: Family Functioning And Child Externalizing And Internalizing Behaviors, Jun-Hong Chen

Brown School Graduate Student Theses and Dissertations

This dissertation investigates the multifaceted dynamics of long-term economic stress and its association with subsequent caregiver psychological well-being and children's internalizing and externalizing behaviors. For a comprehensive measure of household economic stress, this dissertation delves into the severity, duration, and fluctuation of economic stress, considering diverse income and asset profiles. The research framework utilizes and integrates a range of existing theories to create a context for understanding the intricate interplay between economic stress, caregiver mental health, and children's behavioral outcomes. Data are drawn from the Panel Study of Income Dynamics, which includes both information about household economic stress and child …

Intersectional Analysis Of Vaccination Inequity Among Individuals With Disabilities In The United States During Covid-19 Pandemic, Philip Ndoki Ndoki

Walden Dissertations and Doctoral Studies

This study was an investigation of how disability status, types, sociodemographic indicators, and reasons for not receiving vaccinations influenced COVID-19 vaccination rates among individuals with disabilities in the United States. Despite efforts, vaccination disparities persisted, necessitating an understanding of barriers to uptake. Using intersectionality theory and the social determinants of health framework, this study examined the impact of marginalized identities and structural inequalities. Key questions included the association between disability status and vaccination uptake, differences among disability types moderated by sociodemographic factors, and the interaction between disability status and reasons for not vaccinating. Household Pulse Survey data from the US …

Machine Learning-Guided Design Of Nanolubricants For Minimizing Energy Loss In Mechanical Systems, Kollol Sarker Jogesh, Md. Aliahsan Bappy

Mechanical Engineering Faculty Publications

This study explores the significant potential of machine learningguided design in optimizing nanolubricants, focusing on their application in reducing friction and wear in mechanical systems. Utilizing neural networks and genetic algorithms, the research demonstrates how advanced computational techniques can accurately predict and enhance the tribological properties of nanolubricants. The findings reveal that nanolubricants, particularly those containing graphene and carbon nanotubes, exhibit marked improvements in reducing friction coefficients and wear rates compared to traditional mineral oil-based lubricants. Additionally, the enhanced thermal stability and load-carrying capacity of these nanolubricants contribute to substantial energy savings and increased operational efficiency. The study underscores the …

Conservation And Management Of Chondrichthyans In The Mediterranean Sea: Gaps, Overlaps, Inconsistencies, And The Way Forward, Jason Lowther, Lydia Koehler, Ioannis Giovos, Jennifer M. Pytka, Monica Barone, Camille Loth, Dimitirios K. Moutoploulos, Simone Niedermuller, Carlotta Mazzoldi

School of Law, Humanities and Social Sciences

Over one third of sharks, rays and chimaeras (chondrichthyans) are threatened with extinction globally. In the Mediterranean Sea, more than half of chondrichthyan species face this risk, although a variety of international, regional, and national rules and regulations apply directly and indirectly targeting management and conservation for these species. In this work, we provide an overview of relevant legislation and policies in the region, which regulate, inter alia, commercial fisheries, while highlighting through cases studies how implementation in practice at national level looks like. Horizontal gaps and inconsistencies that hinder chondrichthyan management in the region are also illustrated. Furthermore, we …

Context-Dependent T-Box Transcription Factor Family: From Biology To Targeted Therapy, Siwen Li, Xiangyuan Luo, Mengyu Sun, Yijun Wang, Zerui Zhang, Junqing Jiang, Dian Hu, Jiaqian Zhang, Zhangfan Wu, Yufei Wang, Wenjie Huang, Limin Xia

Faculty, Staff and Student Publications

T-BOX factors belong to an evolutionarily conserved family of transcription factors. T-BOX factors not only play key roles in growth and development but are also involved in immunity, cancer initiation, and progression. Moreover, the same T-BOX molecule exhibits different or even opposite effects in various developmental processes and tumor microenvironments. Understanding the multiple roles of context-dependent T-BOX factors in malignancies is vital for uncovering the potential of T-BOX-targeted cancer therapy. We summarize the physiological roles of T-BOX factors in different developmental processes and their pathological roles observed when their expression is dysregulated. We also discuss their regulatory roles in tumor …

The Evolving Role Of Chlorthalidone And Hydrochlorothiazide As First-Line Treatments For Hypertensive Patients, Alan D. Kaye, Sarah C. Corley, Ellen Ingram, Peter P. Issa, Logan T. Roberts, Elisa E. Neuchat, Matthew J. Sharpe, Nicolette Doan, Olga Willett, Adam M. Kaye, Sahar Shekoohi, Giustino Varrassi

School of Medicine Faculty Publications

Hypertension is attributable long-term to various negative health outcomes, including atherosclerotic cardiovascular disease and, more broadly, to cardiovascular events such as congestive heart disease, myocardial infarction, heart failure, and stroke. Effective hypertension treatment is essential to lower the risk of these outcomes. Treatment of hypertension includes both nonpharmacologic and, if necessary, pharmacologic interventions. The drug classes proven in trials to decrease the risk of cardiovascular disease events in cases with hypertension include angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, thiazide diuretics, and calcium channel blockers. When considering thiazide diuretics as a first-line treatment, chlorthalidone (CTD) is currently recommended by the American …

Development Of A Group-Based Behaviour Change Intervention For People With Severe Obesity Informed By The Social Identity Approach To Health, The Progroup Team, Shokraneh Moghadam, Laura Hollands, Raff Calitri, Dawn Swancutt, Jenny Lloyd, Lily Hawkins, Rod Sheaff, Sarah Dean, Steve Perry, Ross Watkins, Jonathan Pinkney, Mark Tarrant

Peninsula Medical School

Introduction: Interventions to support behaviour change in people living with chronic health conditions increasingly use patient groups as the mode of delivery, but these are often designed without consideration of the group processes that can shape intervention outcomes. This article outlines a new approach to designing group-based behaviour change interventions that prioritizes recipients' shared social identity as group members in facilitating the adoption of established behaviour change techniques (BCTs). The approach is illustrated through an example drawn from research focused on people living with severe obesity. Methods: A prioritization process was undertaken in collaboration with stakeholders, including behaviour change experts, …

Penatalaksanaan Okupasi Terapi Pada Down Syndrome Menggunakan Behavior Modification Dan Sensori Integrasi Dalam Aktivitas Toileting (Case Study), Eka Talia Kameswari, Reza Nur Arsyi, Muhammad Luthfi, Hermito Gidion, Ayleen Alicia Kosasi, Abdul Aziz, Erna Faryza Mohd

Jurnal Vokasi Indonesia

Down syndrome is a condition of physical and mental developmental delays caused by chromosomal abnormalities. Children with Down syndrome generally show differences in motor development compared to other children, including delays in developing independence in daily activities. This study evaluates An. N, a 9-year and 9-month-old child with Down syndrome, who has issues with independence, particularly in toileting activities. To address this issue, an occupational therapy program was implemented using behavior modification and sensory integration approaches. The behavior modification techniques employed included positive reinforcement and prompting (physical, verbal, gestural, modeling), while the sensory integration techniques involved play. The results of …

Tolkien: Voyage En Terre Du Milieu (2019), Ed. By Vincent Ferré And Frédéric Manfrin, Deidre A. Dawson

Journal of Tolkien Research

Book review, by Deidre A. Dawson, of Tolkien: Voyage en Terre du Milieu (2019) ed. by Vincent Ferré and Frédéric Manfrin

Sifat Fisika Kimia Tanah Ordo Vertisol Pada Penggunaan Lahan Pertanian, Novita Anis Sholihah, Dwiyono Hari Utomo, Juarti Juarti

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

This research aims to know the physical and chemical properties of Ordo Vertisol soil in agriculture land used (paddy fields, dry fields, and farms). This research uses survey method that is implemented in the field and laborato ry. Samples were obtained by overlaying two maps using Arc-GIS 10.1 software to produce the Land Unit Map, then the sample was taken by using purposive sampling method which consider the land was planted and has decreased of har vested area, or in productivity or the amount of crop production. Descriptive analysis is used to explain the results of the research and the …

Better Together: Attitudinal And Institutional Change For Stereotype And Prejudice Reduction, Diana Quito

Essays in Education

This article begins by examining the adverse effects of ostracization on students' mental health and academic performance. It identifies deficit thinking within educational institutions as contributing to the social exclusion experienced by students, leading to their psychological need for belonging going unmet. Deficit thinking, fuelled by racist and classist ideologies, theorizes that the blame for a student’s failure in school results from their inherent deficiencies. Deficit thinking oppresses and marginalizes students by justifying harmful practices such as school segregation and scientific racism. Schools serving communities of color are disproportionately impacted, compromising students’ educational achievement and prospects. To disrupt deficit thinking, …

The Essential Guide To Playing And Creating Music Online Together, Rebekah Wilson

Journal of Network Music and Arts

No abstract provided.

Telematic Performance In Electronic Dance Music (Edm), Yongsi Wang

Journal of Network Music and Arts

This paper aims to discuss to what extent telematic performances within the framework of the “Beyond Time and Space - London Tokyo Online 2023” initiative serve as a comparative paradigm to physical live performances, particularly in the domains of technical exigencies, artistic expression, and audience engagement.

Central to this study is the “Beyond Time and Space - London Tokyo Online 2023” event, a simultaneous, interactive electronic live music performance connecting physical venues in London and Tokyo. Through JackTrip and Open Broadcaster Software (OBS), this event aspired to explore the applicability and limitations of telematic technology in live electronic music performance …

Kompost*Klang*Küche*: Telematic Worlding With Glitch, Hannah Vyborg Walter, Robert Torche, Cedric Spindler, Eric Larrieux, Patrick Muller

Journal of Network Music and Arts

This paper explores concepts and practices of telematic performances, particularly through the lens of the project kompost*klang*küche*. It emphasizes spatial discontinuity within networked artistic collaborations, as opposed to immersive continuity.

Telematic performance formats utilize network technologies to facilitate low latency artistic endeavors across geographical divides, creating a complex interplay between local, remote, and intermediary spaces. In this context, we interpret spatial configurations from a phenomenological point of view as telematic SPACE in which technical components are in place in three spaces (local, remote and intermediary space) while practiced, embodied and inhabited in an anthropological space, where the overlay and dynamics …

How To Be In Two Places At Once: A Search For The Immersive Experience In Renaissance Music And Visual Arts., Andrew Hallock

Journal of Network Music and Arts

Immersion is a hot topic, but it is often invoked in a vague or shallow way. This essay aims to arrive at a more nuanced consideration of the immersive experience by presenting some perhaps surprising arguments from the past—from Renaissance music and visual arts—drawing parallels with our own time, and positing that the Network Arts can take inspiration from this history to enhance its own immersive endeavours. Four interrelated topics serve as the basis for this investigation: miniature devotionalia, polyphonic canons, anamorphic puzzles, and early cosmology. By using perspective to disclose hidden meanings, ideas, and realities, these varied practices draw …

Connectivity, Presence, And Time: A Pedagogical Experience With Telematic Music, Cássia Carrascoza Bomfim, Alexandre Ficarelli, Danilo Rossetti

Journal of Network Music and Arts

This article aims to discuss the notions of connectivity, presence, and time in the specific context of telematic music. To do so, we describe the work of the Telematic Ensemble LaFlauta, formed by students and professors from the University of São Paulo, Ribeirão Preto campus, for performance at the NowNet Arts Conference 2023.4 This work involved rehearsals and performances of three compositions dedicated to the group: Virtual Studies (2023) by Paulo C. Chagas, Modules 2 - My Words (2023) by Cássia Carrascoza, and Textural Studies (2023) by Danilo Rossetti. We conclude that the positive results of telematic music in a …

Editorial, Sarah Weaver

Journal of Network Music and Arts

No abstract provided.

The Cycle Of Care: An Illustrated History Of Dreyer Medical Clinic, Advocate Health - Midwest

Historical Documents - Combined

An illustrated history of Dreyer Medical Clinic, starting with its original founder, Dr. John W Dreyer in 1905, to the subsequent growth of the Clinic from the partnership he formed in 1922, to the organization's significant accomplishments through 2007.

The Lived Clinical Experiences Of Expatriate Athletic Trainers, Emily K. Mulkey, Elizabeth R. Neil, Trisha Cousins, Mary Murray

Internet Journal of Allied Health Sciences and Practice

One of the ways that healthcare systems have adapted to the needs of patient care is to expand the role of allied healthcare professionals. The utilization of these clinicians, with wide-ranging skill sets, allows for increased adaptability and improved patient outcomes.¹ Expansion of physician reach through allied health professions provides improved connectivity to patients.² While medical communities all have a common goal, the healthcare system varies among nations in terms of the representation of allied healthcare professions.² Within the United States (US), one of the most versatile allied health professions is athletic training. With a skill set …

“Who All Gon Be There?”: On Blackness, Transness, And K-12 Pedagogies For [Black] Trans Futures, Shea W. Martin

Journal of Queer and Trans Studies in Education

Grounded in trans-of-color critique and Black trans studies, this theoretical meditation reckons with the impossibility of Black trans safety, recognition, and futurity within our U.S. K-12 educational landscape. Situated in a “post-Transgender Tipping Point” sociopolitical landscape, I explore how these limitations contribute to Black trans youth’s disparate experiences in today’s schools, particularly with attention to the [in]effectiveness of existing queer and trans pedagogies. In an attempt to locate what is deemed possible for Black trans youth in imagined educational futures, I discuss trends within select K-12 trans pedagogical scholarship through which I explore questions related to authorship, reflexivity, and intersectional …

Optical Glass With Increased Refractive Index Based Bao – B2o3 – Sio2 System, Yury G. Pavliukevich, Ludmila F. Pаpko, Ekaterina E. Trusova

CHEMISTRY AND CHEMICAL ENGINEERING

The aim of the research is to develop lead-free optical glass with increased refractive index based on BaO – B₂O₃ – SiO₂ system. A study of technological and physical-chemical properties of glass was conducted. It has been shown that the glass of this system tends to the phase separation of segregation type. The area of glass composition with refractive index of 1.6195 – 1.6650 has been established. The peculiarities of influence of the modifiers – Al₂O₃ and oxides of the RO group – on the technological and optical properties of the glass of …

Method, System, And Computer Program Product For Object-Oriented Reporting, Gregory Paul Loomis Visa

Defensive Publications Series

A method, system, and computer program product are provided for object oriented reporting. The method includes receiving transaction data associated with a plurality of transactions for at least one account, the transaction data comprising a plurality of fields, generating a data library comprising a plurality of modular and self-contained certified data objects, each modular data and self-contained certified object of the plurality of modular and self-contained certified data objects corresponding to at least one field of the plurality of fields, each modular and self-contained certified data object comprising a tag, a length, and a value, generating a string comprising the …

“Dynamic Schema Evolution”, Harshwardhan Tripathi

Defensive Publications Series

The present disclosure provides a solution for seamless integration of data from diverse sources by dynamically managing schema changes. The solution comprises establishing a base schema during data processing and comparing it to incoming data layouts. Any detected changes, such as new tags or fields, are automatically managed within a staging layer, preventing disruptions to the main dataset. These changes are reviewed by Business and Engineering teams for relevance and compatibility. Only after thorough validation, approved changes are processed into the final dataset. This approach ensures that only validated and reliable data is integrated, maintaining data integrity and minimizing disruptions. …

Influence Of The Moisture On Fumes Derived From The Anfo Detonation, Andrzej Biessikirski, Mateusz Pytlik, Michał Dworzak, Michał Twardosz, Mariusz Wądrzyk, Rafał Janus

Journal of Sustainable Mining

ANFO is one of the most commonly used explosives in open-pit mining, usually produced by mixing systems on the blast site. One of the problems usually not considered is the moisture”s influence on the stored ammonium nitrate(V). The influence of moisture on fumes and the detonation process has been investigated by placing ammonium nitrate(V) prills in the climatic chamber. In the investigation, the influence was evaluated for ANFO samples which were produced based on the two types of fuel oils. It was concluded that the 3.0% moisture level resulted in the lowest NOx content in both case studies. Further increased …

Power Efficient Connectivity Between Mobile Devices, Nazih Almalki, Andy Killen

Defensive Publications Series

Mobile devices, such as wearable computing devices (e.g., smart watches), may default to a particular radio for tethering (e.g., connectivity) with a computing device (e.g., a phone). In accordance with the techniques disclosed herein, a wearable computing device may utilize a connectivity context to proactively provide power efficient connectivity between the wearable computing devices and the computing device. The wearable computing device may select a radio from a plurality of onboard radios based on the connectivity context. The connectivity context may indicate conditions for which the selected radio may be better suited for connectivity (e.g., data transfer) with the computing …

System And Method For Configurable Vehicle Metrics Collection And Reporting, Selim Gurun, Umang Bhatia, Rui Qiu, Sergey Grizan

Defensive Publications Series

This publication describes systems and techniques for implementing a vehicle communications language for describing vehicle system data sources, data collection rules, data processing, and data results using Protobuf for serializing data and establishing an interface description language for communications among various vehicle systems and vehicle data sources. Described techniques may enable vehicle data collection, vehicle data configuration and report generation. Aspects of the disclosure may include end-to-end cloud integration for vehicle systems and data sources utilizing a digital twin of a subject vehicle within the infrastructure of a cloud services provider and defining within the digital twin, available vehicle services, …