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Glutathione Dynamics In Subcellular Compartments And Implications For Drug Development, Jin Wang Aug 2024

Glutathione Dynamics In Subcellular Compartments And Implications For Drug Development, Jin Wang

Faculty, Staff and Students Publications

Glutathione (GSH) is a pivotal tripeptide antioxidant essential for maintaining cellular redox homeostasis and regulating diverse cellular processes. Subcellular compartmentalization of GSH underscores its multifaceted roles across various organelles including the cytosol, mitochondria, endoplasmic reticulum, and nucleus, each exhibiting distinct regulatory mechanisms. Perturbations in GSH dynamics contribute to pathophysiological conditions, emphasizing the clinical significance of understanding its intricate regulation. This review consolidates current knowledge on subcellular GSH dynamics, highlighting its implications in drug development, particularly in covalent drug design and antitumor strategies targeting intracellular GSH levels. Challenges and future directions in deciphering subcellular GSH dynamics are discussed, advocating for innovative …

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A Group 3 Medulloblastoma Stem Cell Program Is Maintained By Otx2-Mediated Alternative Splicing, Liam D Hendrikse, Paul Layug, Victor Gordon, Kimberly A Aldinger, Parthiv Haldipur, Stephanie Borlase, Ludivine Coudière-Morrison, Ting Cai, Emma Martell, Naomi M Gonzales, Gareth Palidwor, Christopher J Porter, Stéphane Richard, Tanveer Sharif, Kathleen J Millen, Brad W Doble, Michael D Taylor, Tamra E Werbowetski-Ogilvie Aug 2024

A Group 3 Medulloblastoma Stem Cell Program Is Maintained By Otx2-Mediated Alternative Splicing, Liam D Hendrikse, Paul Layug, Victor Gordon, Kimberly A Aldinger, Parthiv Haldipur, Stephanie Borlase, Ludivine Coudière-Morrison, Ting Cai, Emma Martell, Naomi M Gonzales, Gareth Palidwor, Christopher J Porter, Stéphane Richard, Tanveer Sharif, Kathleen J Millen, Brad W Doble, Michael D Taylor, Tamra E Werbowetski-Ogilvie

Faculty, Staff and Students Publications

OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is amplified in a subset of tumours and overexpressed in most cases of group 3 and group 4 MB. Here we demonstrate a noncanonical role for OTX2 in group 3 MB alternative splicing. OTX2 associates with the large assembly of splicing regulators complex through protein-protein interactions and regulates a stem cell splicing program. OTX2 can directly or indirectly bind RNA and this may be partially independent of its DNA regulatory functions. OTX2 controls a pro-tumorigenic splicing program that is mirrored in human cerebellar rhombic lip origins. Among …

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Variation In Zero Plane Displacement And Roughness Length For Momentum Revisited, Ashvath Singh Kunadi, Richard P. Silberstein, Sally E. Thompson Aug 2024

Variation In Zero Plane Displacement And Roughness Length For Momentum Revisited, Ashvath Singh Kunadi, Richard P. Silberstein, Sally E. Thompson

Research outputs 2022 to 2026

Zero plane displacement height (d0) and momentum roughness length (z0m), describe the aerodynamic characteristics of a vegetated surface. Usually, d0 and z0m are assumed to be constant functions of the physical characteristics of the surface. Prior evidence collected from the literature and our examination of flux tower data show that d0 and z0m vary in time at sites with tree and shrub canopies, but not grasslands. The conventional explanations of these variations are based on linear functions of wind velocity and friction velocity, with little theoretical basis. This study explains the variation in aerodynamic parameters by matching four analytical canopy …

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Assessing Sarcopenia In Advanced-Stage Ovarian Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Case Series, Christelle Schofield, Dennis R. Taaffe, Robert U. Newton, Daniel A. Galvão, Paul A. Cohen, Jin Soo Kim, Tarek Meniawy, Carolyn Peddle-Mcintyre Aug 2024

Assessing Sarcopenia In Advanced-Stage Ovarian Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Case Series, Christelle Schofield, Dennis R. Taaffe, Robert U. Newton, Daniel A. Galvão, Paul A. Cohen, Jin Soo Kim, Tarek Meniawy, Carolyn Peddle-Mcintyre

Research outputs 2022 to 2026

Objectives: In ovarian and other cancers, low muscle mass and density are associated with poorer clinical outcomes. However, screening for cancer-related sarcopenia (typically defined as low muscle mass) is not routinely conducted. The European Working Group on Sarcopenia in Older People (EWGSOP) recommends an algorithm for sarcopenia screening and diagnosis in clinical settings, with sarcopenia based on muscle strength and mass, and severity on physical performance. We explored the application of the EWGSOP2 algorithm to assess sarcopenia in six ovarian cancer patients receiving neoadjuvant chemotherapy. Methods: We assessed sarcopenia risk with the SARC-F screening questionnaire (at risk ≥4 points), muscle …

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A Gendered Lens On Mediation And Market Governance: Experiences Of Women Market Vendors In Papua New Guinea, Wilma Langa, Jackie Kauli, Verena Thomas Aug 2024

A Gendered Lens On Mediation And Market Governance: Experiences Of Women Market Vendors In Papua New Guinea, Wilma Langa, Jackie Kauli, Verena Thomas

Research outputs 2022 to 2026

The majority of market vendors at urban informal markets in Papua New Guinea are women. They face vulnerabilities related to safety, security and infrastructural support. They operate within male-dominated mediation structures where women’s contributions to mediation and market governance are often invisible. However, in this article, we demonstrate how women market vendors contribute to the social aspect of market governance, particularly addressing issues of law and order within Awagasi market. Through the efforts of women vendors in mediation and conflict management, safety in the market and normal operation of the informal market have improved. The study involved 18 women market …

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First Diffusion Course: "The Structure Of Language As A Connection Between Artificial Intelligence, Information And Ethics", Dioneia Monte-Serrat Jul 2024

First Diffusion Course: "The Structure Of Language As A Connection Between Artificial Intelligence, Information And Ethics", Dioneia Monte-Serrat

Journal of Humanistic Mathematics

From August 22nd to November 21st, the first Diffusion Course on “The structure of language as a connection between artificial intelligence, information and ethics” will take place on a Thursday of each month, in Ribeirao Preto, Brazil. You are cordially invited to sign up for in-person classes and join other researchers and students on this course.

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7th International Conference On Creative Mathematical Sciences Communication (Cmsc`24), Frances A. Rosamond Jul 2024

7th International Conference On Creative Mathematical Sciences Communication (Cmsc`24), Frances A. Rosamond

Journal of Humanistic Mathematics

The 7th International Creative Mathematical Sciences Communication (CMSC) conference is scheduled for October 2024 in Trier, Germany. Initiated in Darwin, Australia in 2013, CMSC aims to explore novel methods of imparting computational thinking to diverse audiences including non-specialists, modern citizens, and children. Participants from around the world and from various and interdisciplinary disciplines such as science, education, dance, drama, and visual arts convene to exchange ideas, present experimental approaches, and collaborate on engaging children in the exploration of ongoing, unresolved research challenges.

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Oh Statistics!, Heather L. Cook Jul 2024

Oh Statistics!, Heather L. Cook

Journal of Humanistic Mathematics

This poem was written about statistics and the usefulness thereof.

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Discordium Mathematica - A Symphony In Aleph Minor, Vijay Fafat Jul 2024

Discordium Mathematica - A Symphony In Aleph Minor, Vijay Fafat

Journal of Humanistic Mathematics

How did Mathematics arise? Who created it? Why is it subject to Godel’s Incompleteness Theorems? And what does all this have to do with Coleridge’s poem, “Kubla Khan”, and “The Person from Porlock”? Here is a complete mythology of Mathematics set in an epic poetry format, fusing thoughts and verses from Western religions and Eastern mysticism… Those with immense patience and careful reading shall reap the fruit… (best read on a large screen or in printed form)

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Pi: A Perpetual Journey, Ravindra K. Bisht Jul 2024

Pi: A Perpetual Journey, Ravindra K. Bisht

Journal of Humanistic Mathematics

A brief history of the constant pi is presented with a poetic flavor.

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Love Is No Mean Thing: A Larkin Logarithm, Michael P.H. Stanley Md Jul 2024

Love Is No Mean Thing: A Larkin Logarithm, Michael P.H. Stanley Md

Journal of Humanistic Mathematics

This poem was recited at a marriage recently in Vermont. I met the groom in my freshman year. He was the first college friend I ever made, and he used to burst into the room like Cosmo Kramer and settle down in an easy-chair to think about math (my side of the dorm was quieter than his). I thought that was remarkable and delightful, and so, when the task came to write a matrimonial poem for him, I selected a mathematical conceit. The poem concludes with a mathematical paraphrasing of Philip Larkin's last line from Arundel Tomb.

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Eighth Grade Algebra, Joseph Chaney Jul 2024

Eighth Grade Algebra, Joseph Chaney

Journal of Humanistic Mathematics

This is a poem about the affirming power of algebra in the life of a teenager.

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Prime Motivation Of Eratosthenes, Pamela L. King Jul 2024

Prime Motivation Of Eratosthenes, Pamela L. King

Journal of Humanistic Mathematics

The sieve of Eratosthenes is used as a metaphor for the concept of people falling through the social safety net, and people who were once excluded, making efforts to increase inclusiveness.

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Poems From The Series "At The Dimensional Border", Philip Fried Jul 2024

Poems From The Series "At The Dimensional Border", Philip Fried

Journal of Humanistic Mathematics

Poems about the border between the second and third dimensions, on geometry and the human condition.

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Mathematical Graffiti: Bridges 2023 Clerihew Collection Jul 2024

Mathematical Graffiti: Bridges 2023 Clerihew Collection

Journal of Humanistic Mathematics

Clerihews are poems of a form invented by Edmund Clerihew Bentley around the turn of the 19th-20th century. The poems are typically biographical, humorous, and are made up of two couplets. The rhyming pattern is always aabb, but the meter of the two couplets is usually not the same. The first line is simply the name of the person, the other three lines relate to the subject, often in an absurd way. If the rhyme is slightly off, or the rhythm irregular or awkward, or the facts a bit confused, so much the better. The present collection of clerihews, written …

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Book Review: How To Expect The Unexpected: The Science Of Making Predictions -- And The Art Of Knowing When Not To By Kit Yates, Mark Huber Jul 2024

Book Review: How To Expect The Unexpected: The Science Of Making Predictions -- And The Art Of Knowing When Not To By Kit Yates, Mark Huber

Journal of Humanistic Mathematics

Humans think about the future all the time. Prediction is a part of how we prepare for the coming of both good and bad events in our lives. Kit Yates' book, How to expect the unexpected, concentrates primarily on the question of why prediction is difficult, and what mental shortcuts people take in prediction that can lead to incorrect results. Unfortunately, a lack of concern for details and several omissions undermine the quality of the book.

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The Value Of Adding Nothing: A Call For Reform-Oriented Polynomial Division, Jonathan Clark, Jeneva Clark Jul 2024

The Value Of Adding Nothing: A Call For Reform-Oriented Polynomial Division, Jonathan Clark, Jeneva Clark

Journal of Humanistic Mathematics

The call to implement reform practices in schools reflects the historical turn away from the behaviorist theory of learning in education. Yet the praxis of this turn remains a significant challenge, particularly within mathematics classrooms where procedural memorization is emphasized. In this article, we show one means of how to advance our pursuit of meaningful mathematics into polynomial division. Building on the literature for reform-based division methods, an alternative to the long division algorithm will be explored that relies solely on adding zero and fundamental algebraic principles.

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Geometric Shapes That Sing And Move: An Interdisciplinary Lesson With Pre-Service Teachers, Gladys Krause, Gustavo Velandia Jul 2024

Geometric Shapes That Sing And Move: An Interdisciplinary Lesson With Pre-Service Teachers, Gladys Krause, Gustavo Velandia

Journal of Humanistic Mathematics

Our work shares a practical example of an interdisciplinary lesson in which two teacher educators collaborated to integrate mathematics and music in an elementary mathematics methods course. This paper describes the process of collaboration in designing the lesson and shares original instructional resources to be used in the classroom. We also discuss what the pre-service teachers participating in the lesson shared about their learning experience, and what we, the teacher educators, learned from this experience. In presenting this work we aim to promote the opening of spaces in teacher preparation programs that allow pre-service teachers to develop their own instructional …

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Fibonacci-Inspired Spiral Quilts, Kathleen Offenholley, Sk Collins, David Radcliffe Jul 2024

Fibonacci-Inspired Spiral Quilts, Kathleen Offenholley, Sk Collins, David Radcliffe

Journal of Humanistic Mathematics

This article provides insight into the mathematics and designs of quilts inspired by Fibonacci and logarithmic spirals. We introduce the history and development of the Fibonacci number sequence and how to hand-draw a Fibonacci spiral. Further, we explain the relationship between the Fibonacci spiral and logarithmic spirals, the advantages of using logarithmic spirals to create designs, and how to produce digital spiral designs using Desmos, a free web-based graphing calculator. Finally, we discuss methods for designing spiral quilts or other triangle and spiral designs (such as collage or other media) and derive a formula for calculating the apex angles of …

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States Of Matter, Todd Sformo Jul 2024

States Of Matter, Todd Sformo

Journal of Humanistic Mathematics

This is a non-fiction essay overtly about three methods used in overwintering physiology, set in the context of my first learning them, along with associated thoughts and ideas as I began working on my PhD. The mathematics shows up mainly in the final section of the essay whose subtitle plays on a poem by Wallace Stevens called “Anecdote of the Jar”. This section is fable-like in its explanation of protein purification and begins with an impossible statement that is slowly adjusted to make sense by words and math.

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Badass Women, Richard Delaware Jul 2024

Badass Women, Richard Delaware

Journal of Humanistic Mathematics

In this true story, one mathematics major supports another in an unexpected way.

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Intuitive Explanations In Mathematical Education, Jerzy Pogonowski Jul 2024

Intuitive Explanations In Mathematical Education, Jerzy Pogonowski

Journal of Humanistic Mathematics

I discuss the role of intuitive explanations in the learning, teaching, and popularization of mathematics. Several examples of such explanations are presented, related to linguistic explanations, perception, empirical models, and internal explanations inside mathematics itself. I emphasize the fact that intuitive explanations in a sense transgress mere mathematical arguments. I also discuss in brief the role of paradox resolution in mathematical education.

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Bootstraps And Scaffolds: What A Cognitive-Historical Analysis Of The Complex Number System Reveals About Numerical Cognition, Charles R. Card, Gary G. Miller Jul 2024

Bootstraps And Scaffolds: What A Cognitive-Historical Analysis Of The Complex Number System Reveals About Numerical Cognition, Charles R. Card, Gary G. Miller

Journal of Humanistic Mathematics

The following investigation is a cognitive-historical analysis of the conceptual development of complex numbers. The history of this development spans nearly two millennia, from the earliest appearance of the square root of a negative quantity in the calculations of Heron of Alexandra (1st Century CE) to the full flowering of complex numbers in the first half of the 19th Century. The approach used for this analysis is Nersessian's, including her formulations of model-based reasoning and mental models. Additional aspects of the analysis feature the prominent roles played by process representations, including object-process complementarities, and by core numerical systems. Our analysis …

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Building Communities Of Care For Equity, Justice, And Culturally Responsive Practice In Mathematics Education, Nicole Fletcher, B Waid Jul 2024

Building Communities Of Care For Equity, Justice, And Culturally Responsive Practice In Mathematics Education, Nicole Fletcher, B Waid

Journal of Humanistic Mathematics

Teaching is widely considered one of the “caring professions,” but conceptualizations of care and how care is put into practice in education are not universal. In this article, we draw from a range of perspectives on care that integrate supportive interpersonal relationships, high expectations, and culturally relevant theories of critical care, as well as Queer Theory and Disability Justice, to explore the application of these ideas in mathematics education. We identify key elements for building communities of care in mathematics education contexts: co-constructing community agreements, redefining participation, shifting traditional power structures, collaborative problem solving, and building networks of care beyond …

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Mathematical Models And Pedagogy Of Marxist Political Economy, Christopher Perez Jul 2024

Mathematical Models And Pedagogy Of Marxist Political Economy, Christopher Perez

Journal of Humanistic Mathematics

How can we teach people about the economics of labor and exploitation in mathematics courses? We define a mathematical model for describing the relationships embodied by commodities and labor. We then use this model to illustrate the exploitative nature of profit and the tendency for catastrophic chain-reactions that lead to market crashes. Lastly, we discuss applications to pedagogy in mathematics courses using a simplified version of the model.

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The Braids On Your Blanket, Michelle Cheng, Robert Uwe Laugwitz Jul 2024

The Braids On Your Blanket, Michelle Cheng, Robert Uwe Laugwitz

Journal of Humanistic Mathematics

In this expository essay, we introduce some elements of the study of groups by analysing the braid pattern on a knitted blanket. We determine that the blanket features pure braids with a minimal number of crossings. Moreover, we determine polynomial invariants associated to the links obtained by closing the braid patterns of the blanket.

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What Is An Imaginary Number? The Plane And Beyond, Andrew W. Powell Jul 2024

What Is An Imaginary Number? The Plane And Beyond, Andrew W. Powell

Journal of Humanistic Mathematics

In this article I argue that i is a quantity associated with the two-dimensional real number plane, whether as a vector, a bi-vector, a point or a transformation (rotation). This position provides a foundation for the complex numbers and accounts for complex numbers in some equations of applied mathematics and physics. I also argue that complex numbers are fundamentally geometrical and can be described by geometric algebra, and that moreover the meaning of complex numbers in physics varies with dimension and geometry of the manifold.

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Millions, Billions, Or Trillions: How To Partition Large Numbers Into Friendly Figures, Eryn Michelle Maher, Ha Nguyen, Cynthia Sanchez Tapia Jul 2024

Millions, Billions, Or Trillions: How To Partition Large Numbers Into Friendly Figures, Eryn Michelle Maher, Ha Nguyen, Cynthia Sanchez Tapia

Journal of Humanistic Mathematics

Communicating and making sense of large numbers — millions, billions, and trillions — is a persistent struggle in our society. Using large numbers is a learning requirement for elementary school children, but even adults struggle with it. Hence supporting future teachers in developing their own understanding of the concepts is valuable. To construct, enact, and revise an educational experience for preservice teachers, we apply three frameworks of teaching mathematics for social justice tasks, high cognitive demand tasks, and productive mathematics discussion. The context uses United States educational and defense spending, the national budget, and the gross domestic product. Preservice teachers …

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Language Analysis Via The Run And Flattened Statistics On Permutations, Jennifer Elder, Pamela E. Harris, Anthony Simpson Jul 2024

Language Analysis Via The Run And Flattened Statistics On Permutations, Jennifer Elder, Pamela E. Harris, Anthony Simpson

Journal of Humanistic Mathematics

A permutation π in Sn can be decomposed into its runs π = τ1τ2 . . . τk, where a run of π is a maximal contiguous subsequence whose elements are in increasing order. If the first values of each run are in increasing order, then π is said to be flattened. Motivated by the study of flattened permutations, we study the words in the Danish, German, English, Spanish, French, Italian, Dutch, and Norwegian languages. In each language considered, our work provides the following: a list of the longest flattened words, histograms for the proportion …

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The Modern Geometrician: Euclidean Construction For Digital Paper, Deborah A. Kent, David J. Muraki Jul 2024

The Modern Geometrician: Euclidean Construction For Digital Paper, Deborah A. Kent, David J. Muraki

Journal of Humanistic Mathematics

The emphasis on traditional hand-drawn compass and straight-edge geometrical constructions has been reduced in the core narrative of most current curricula. In response to this trend, this paper presents a virtual toolkit for producing precision geometrical figures within the popular note-taking app, Notability. These graphical procedures employ the app's stylus-based input and shape tools (for lines, circles and squares) to offer a modern take on classical geometrical construction. These procedures are adaptations of familiar textbook methods, necessary because the app's circle-drawing tool behaves differently from a standard compass. Beyond the familiar canon of elementary Euclidean constructions, such as angle bisectors …

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