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Labrad : Vol 49, Issue 2 - December 2024, Aga Khan University Hospital, Karachi

LABRAD - Departments of Pathology & Laboratory Medicine and Radiology Archives

• EDITORIAL
• ARTICLES
• Anti-Glomerular Basement Membrane (GBM) Disease: Pathogenesis, Presentation, and Diagnostic Insights
• Advanced Total Laboratory Automation (TLA) Workflow: A Comprehensive Approach towards High-Throughput Analyzers in Clinical Chemistry
• Precision Under Pressure: Challenges in Therapeutic Drug Monitoring for Immunosuppressants
• Frozen Section: Diagnostic Accuracy, Pitfalls and Use of Digital Pathology
• Working Environment Perspective of a Learner
• AI Training: A Must-Have Skill for Tomorrow’s Radiologists
• Challenges in Blood Supply: Importance of Voluntary Donations
• Leadership Skills and Emotional Intelligence For Professional Capacity Building in Histopathology – A Broad Perspective
• Factor VIII and XI Deficiency; A Finding That Could Have Been Missed-A Case Report
• Accelerated Phase …

Exploring Diet Quality, Food Insecurity, And Health Status Among Utah Residents, Palak Gupta, Lendel Narine

Journal of Human Sciences and Extension

A lower-quality diet is a significant contributor to preventable mortality worldwide. This study investigated the intricate relationships between diet quality, food insecurity, and health status among residents in Utah. Using a cross-sectional survey design with a sample size of 1,522 participants, data were collected through an online survey focusing on household characteristics, diet quality, health status, and food security. The primary exposure, household food insecurity, was assessed using a validated 6-item scale, while diet quality was measured through a modified Rapid Eating Assessment for Participants– Shortened Version (REAP-S). The findings revealed an association between very low food security and poor …

Personal Protective Equipment For Minoritized U.S. Agricultural Farmworkers: Community-Based Efforts During The Pandemic & Implications For Extension, Helen Trejo

Journal of Human Sciences and Extension

There are an estimated 2 million farmworkers who are essential to the food system in the United States; however, they are exposed to hazardous environmental conditions with limited access and/or use of Personal Protective Equipment (PPE). The primary purpose of this research is to evaluate community-based organizational efforts to provide farmworkers with apparel-textile basic needs, such as face masks. A primary goal is to address the research gap regarding common environmental factors that impact farmworkers, including pesticides and the pandemic, their use of available PPE, and community-based efforts to improve access to face masks as basic PPE. We consider the …

Synthesis Of Novel Chromenone Esters For Biochemical Assays, Andrew Dean Helmerich

Undergraduate Honors Thesis Collection

This project details the synthesis of a variety of novel chromenone esters to be used as enzymatic probes. A robust, initial library of 22 chromenone esters was successfully synthesized with differences in chain length, branching, and the incorporation of cyclic and heteroatomic moieties. These new chromenones were fully characterized by 1HNMR, 13CNMR, DEPT HRMS, 19FNMR, and HSQC. The utility of these compounds comes from the fact that they will fluoresce upon cleavage of the ester; thus, this property makes them ideal candidates to be used in the monitoring of enzymatic activity of esterases. Elucidating the enzyme-substrate structure activity relationship (SAR) …

From Crisis To Prevention: Mining Big Data For Public Health Insights During The Flint Water Crisis, Charles Knoble, Gift Fabolude, Anvy Vu, Danlin Yu

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

This study investigates the utility of Google Trends and Google Search data in retrospectively analyzing the Flint Water Crisis, a significant public health event. By examining keywords relevant to the crisis, such as “lead,” “bottled water,” “water filters,” “pneumonia,” and “Legionnaires’ Disease,” we aimed to uncover patterns in public awareness and response during a public crisis and explore how such awareness and responses could potentially aid in reducing the risk of similar crises in the future. Our analysis reveals a clear correlation between search frequencies and the crisis timeline, with spikes in search terms corresponding to key events. This suggests …

73 | ‘Akko Iii: The 1991–1998 Excavations: The Late Periods Part 2: The Knights’ Hotel Site, The Messika Plot And Miscellaneous Studies, Danny Syon, Ayelet Tatcher

IAA Reports—Monograph Series of the Israel Antiquities Authority

Akko III: The Late Periods comprises two parts (IAA Reports 72 and 73), the third and fourth volumes in a series publishing the results of four excavations that took place within and just outside of the Old City of ‘Akko between 1991 and 1998. These two volumes present the archaeological finds from the Early Islamic to Ottoman periods, concentrating on the architecture and small finds from the Crusader period.

The present volume (Part 2; IAA Reports 73) presents the excavations in the Knights’ Hotel Site, which yielded a wealth of small items of daily use, including glass finds, lead ampullae, …

The First World War Letters Of H.J.C. Peirs: A Case Study Of The Creation And Growth Of A Collaborative, Pedagogy-Driven Digital History Project, Amy E. Lucadamo, R.C. Miessler, Ian A. Isherwood

All Musselman Library Staff Works

This chapter concerns the development of a First World War Digital Humanities project at a small US liberal arts college. The project, based on a manuscript collection of documents, photographs, artefacts, and nearly 300 letters (primarily written between 1915 and 1919), was designed from the beginning to be truly collaborative, featuring the creative and scholarly work of undergraduate students, a faculty member, a librarian, and an archivist to tell a unique story from the Western Front. What initially began as a project to digitally preserve and promote primary source materials for a wider audience adapted and changed over the course …

Condition And Management Futures In A Quaking Aspen Recreation Area. Final Report To Snyderville Basin Special Recreation District, Paul C. Rogers, Georgie Corkery, Anna B. Miller

Aspen Bibliography

In partnership with Snyderville Basin Special Recreation District (SBSRD), we undertook a study of ecological conditions and user preferences within a quaking aspen recreational destination forest. The location, in two sections know as Run-A-Muk and Right Turn Sage (RAM/RTS), has experienced some forest die-off in the principally aspen dominated forest dissected by ski, bike, and hiking trails. Graduate student Georgie Corkery led the study and successfully completed a Master's degree, in addition to providing needed information to SBSRD regarding the status, uses, and preferred actions at this facility. Key outcomes regarding aspen conditions include assigning causal factors—ungulate browsing and elevated …

Parole Under Ina 212(D)(5)(A): Balancing Humanitarian Needs And Legal Boundaries, Jorge Miguel Magdaniel Manzur

Immigration Law Blog

This article examines how various uses and interpretations of parole under INA § 212(d)(5) have shaped immigrants' access to benefits, highlighting the balance between executive discretion and statutory limits within recent political and humanitarian contexts.

Comparing Cardiometabolic Monitoring And Side Effect Management In A Pharmacist-Led Ambulatory Clozapine Clinic Versus Standard Care., Nicholas Buttermore Pharmd, Jenna Gilbert Pharmd, Bcpp, Naana Boachie Pharmd, Bcacp, Kenneth Wiley Pharmd, Bcacp, Sarah Ferrell Pharmd, Bcpps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. New Orleans, LA

This study found that cardiometabolic monitoring rates were significantly higher in the pharmacist group compared to standard care, and that clozapine-related side effects were screened more frequently.

High Yield Of Congenital Hypothyroidism Among Infants Attending Children Hospital, Nairobi, Kenya. Facility Based Study In The Absence Of Newborn Screening, Menbere Kahssay, Thomas Ngwiri

Paediatrics and Child Health, East Africa

Objectives: Congenital hypothyroidism (CHT) is a treatable cause of intellectual disability. Late diagnosis and delayed initiation of treatment leads to irreversible neurodevelopmental and intellectual disability. Thus, newborn screening is crucial. However, 71 % of babies are born in an area with no established newborn screening program and Kenya is not an exception. We aimed to determine the incidence of CHT, developmental outcomes of patients in the absence of newborn screening.

Methods: A retrospective data of subjects who met the inclusion criteria, newborn and infants from 3 days to 2 years whose thyroid function test (TFT) was undertaken during well baby …

Workforce Barriers And Needed Supports To Enhance Behavioral Health Service Provision For Older Adults In Nebraska, Cecilia Y.M. Poon, Shinobu Watanabe-Galloway, Yadi Liu, Charles Yale, Deepanjali Bhale, Erin O. Schneider, Julia F. Houfek, Christine Chasek, Marley Doyle, Kendra Ratnapradipa

Reports and White Papers: Behavioral Health Education Center of Nebraska

Nearly 20% of US older adults have mental health concerns, but few mental health professionals specialize in this population. In Nebraska, where almost 17% of Nebraska’s population is >65 years of age, BHECN conducted a survey to understand provider attitudes about and abilities to serve the state’s older population. Results from this online survey of licensed mental health practitioners in 2022 showed that 61% of responding practitioners were rural, 27% did not provide direct clinical services to older adults, and only 18% of their time was spent working with older adults. Barriers to providing care to older adults included Medicare …

Rehydration Kinetics Of Green Pea Grains Dried At Different Microwave Powers, Serap Kayisoglu

The Philippine Agricultural Scientist

In this study, both untreated and pre-treated green pea grain samples dried at different microwave output powers (90, 180, and 360 W) were rehydrated at three different temperatures (30ºC, 50ºC, and 70ºC). The rehydration kinetics of dried peas were analyzed using both the Peleg and the first-order kinetic models. Observations revealed that the Peleg model exhibited better agreement with the experimental data. As both microwave power and rehydration temperature increased, the rehydration capacity also increased in both pre-treated and untreated peas. The highest moisture content was observed after rehydration in pre-treated peas dried at 360 W microwave power (2.80 g …

Thermal Anharmonicity Of Transition Metals: A Case Study Of Tantalum, Bimal K C

Open Access Theses & Dissertations

Density functional theory (DFT) is commonly used for evaluating the thermal propertiesand equation of state of solids, usually within the quasi-harmonic approximation (QHA). In transition metals, thermodynamic quantities such as the thermal pressure and Gruneisen parameter are poorly reproduced compared with experimental values or with direct computational methods like quantum-molecular dynamics (QMD) simulations. Surprisingly, there has not been to date, a systematic study aimed at understanding the reasons for these discrepancies. Using Tantalum as a case study, we have evaluated the temperature dependence of the phonon frequencies employing Harmonic Ensemble Lattice Dynamics (HELD) combined with classical and quantum molecular dynamics. …

Restoration Of The Cantilever Deck Structure, Calvin P. Vigeant, Roger G. Biddle, Calvin S. Morgan

Architectural Engineering

The Restoration of the Cantilever Deck Structure is an inter-disciplinary project seeking to provide public safety, the continuity of a historic structure, and contribute to the life of the Poly Canyon Experimental Structures Laboratory. This project brought together architectural engineering students Roger Biddle and Calvin Vigeant and construction management student Calvin Morgan for a year long journey of Learn by Doing. The structure is visually stunning and gives the impression of a ship cresting a wave, featuring two prominent steel masts and large tapered wood beams. The deck is perched on a steep hillside site over a seasonal creek that …

Livable Marshfield: Age And Dementia Friendly Action Plan: Improving Livability For All Ages And Abilities, Caitlin E. Coyle, Beth Rouleau, Ceara Somerville

Center for Social and Demographic Research on Aging Publications

The Town of Marshfield’s Age and Dementia Friendly action plan signifies a milestone and reflects many years of dedication to creating environments within Marshfield that are supportive of residents of all ages and abilities. Guided by the Council on Aging (COA), the Town of Marshfield is dedicated to understanding and responding to the needs and interests of older adults in the community. Over the years, the share of residents over age 60 has steadily grown. According to 2019-2023 estimates from the American Community Survey, an estimated 28% of Marshfield residents are age 60 or older (approximately 7,200 residents). Projections suggest …

Metagenomic Sequencing For Early Detection Of Future Engineered Pandemics: Foreshadowing The Privacy Challenge, Nir Eyal, Bridget Williams, Kevin M. Esvelt, Jane R. Bambauer

UF Law Faculty Publications

In this commentary, we imagine how a global system of metagenomic sequencing could be governed in order to reap the benefits and manage the risks. Global institutional engineers and their academic partners would need to develop a new governance model to ensure that all partners involved in a global metagenomic surveillance system cooperate as needed.

Mental Health Survey With Client Feedback, Alessia Grace Jimenez

Capstone Projects and Master's Theses

Addressing mental health stigmas in lower-income communities and taking in client feedback to give better results back to clients. Monterey County Behavioral Health Access to Treatment provides crisis services, alcohol and substance abuse support, transitional youth programs, and access services to those with mental health disorders. The agency serves only those with medical insurance in the Monterey County area. The purpose of the mental health survey, along with client feedback, is to track client progress and outcomes. This can help ensure that clients receive the support and care that is most relevant to their individual circumstances. The most important findings …

Indisposed To Write: Teaching A Visceral Poetics, Miriam L. Atkin

The Journal of the Assembly for Expanded Perspectives on Learning

This essay begins from the premise that acts of thinking and writing are shaped immanently by corporeal need. Accordingly, my aim is to sketch a vision of composition pedagogy that acknowledges the moves and modulations of the thinking body. The route I take to get there explores four works of critical prose that mobilize form and content toward a radical re-orientation of body-in-space and body-in-writing. These texts—by Eleni Stecopoulos, Robert Kocik, William James, and Eli Clare—are to varying degrees experimental, demonstrating a manner of textual difficulty that signals the visceral difficulty implied in any act of writing. What follows is …

Effect Of Integrated Crop–Livestock Systems On Soil Properties And Microbial Diversity In Soybean Production, Namita Sinha, Brett R. Rushing, Aniruddha Acharya, Shankar Gaapathi Shanmugam

Faculty Publications - Biological Sciences

Integrated crop and livestock systems (ICLSs) have been considered an important management-based decision to improve soil health by carbon sequestration. A two-year study (2019–2021) at CPBES in Newton, MS, was conducted to evaluate the effect of an ICLS on soil microbial diversity in the southeastern region of the USA, representing agroclimatic conditions that are warm and humid. Amplicons targeting bacterial 16S rRNA genes and fungal ITS2 regions were sequenced. Taxonomic assignment and characterization of microbial diversity were performed using QIIME2®. Soil fungal diversity pattern showed significant difference (alpha diversity, p = 0.031 in 2020 and beta diversity, p = 0.037 …

Full Issue, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

The Effect Of Common Road Salts And Organic Additives On Microbial Respiration In Urban Streams, Claire Meara

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

Due to significant population growth and urbanization, there has been an increase in impervious surfaces such as roads and sidewalks. During winter, impervious surfaces are often treated with salt to make road conditions safer. However, this has significant impacts on water quality when salt enters urban streams during runoff events. The addition of road salts to urban streams has been shown to have detrimental effects to various organisms across trophic levels and affects nutrient cycling and greenhouse gas release. These findings have made the development of alternative treatments necessary, such as using organic additives, like beet juice, which can decrease …

Citizens’ Perceptions Of Wetlands Before And During The Restoration Of A Local Wetland, Delaney Ringgold

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

This study investigates the impact of a wetland restoration project on homeowners' perceptions and knowledge of wetlands in a residential area in Fayetteville, Arkansas. The research employs a pre- and during-restoration survey methodology to assess shifts in public perception and awareness of wetland environments. As part of the restoration project, native vegetation was reintroduced, and non-native species were removed, with the goals of ecological enhancement and improving the visual appeal of the wetland area. Surveys, consisting of Likert-scale questions and open-ended responses, were administered to homeowners before and during the restoration process to capture changes in demographic factors, wetland knowledge, …

Analyzing Food Sources And Food Insecurity Of Kichwa Farming Families In The Ecuadorian Amazon, Reina Watanabe

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

While the right to food is internationally recognized and the United Nations established the sustainable development goal to end hunger and achieve food security by 2030, many households remain without consistent access to food in 2024. In Latin America, approximately 4 in 10 households were reported as food insecure in 2020 with higher rates in rural and indigenous communities. Rural areas, which have great overlap with indigenous communities in Ecuador, experience disproportionately high levels of poverty and food insecurity compared to urban areas. The most populous indigenous nationality in the Ecuadorian Amazon and the participants of this study are the …

Valor: Villains, Creatures And Foes - A Tabletop Roleplaying Game Expansion And A Methodology For Planning And Managing Tabletop Roleplaying Game Projects, Erik Ryan Ottosen

Student Projects for Graduate Degrees

Valorous Games, an independent developer and producer of Tabletop Roleplaying Games (or TTRPGs), has successfully executed three book development projects over the past seven years (the third project being a reprint and update of their first book), in addition to smaller ancillary projects. In 2023, it was determined that rescoping and restarting their third book, Valor: Villains, Creatures and Foes, would better align with future goals for the company and its proprietor. Initial research showed that little to no academic material exists for study of Project Management (or PM) in the context of the Tabletop Role-Playing Game hobby; thus, it …

How Detrimental Is Transunion V. Ramirez, Really? Understanding The Impact On Environmental Law, Lauren Young

Washington Law Review

In 2021, the United States Supreme Court issued a controversial opinion with the potential to constrict the standing doctrine. TransUnion v. Ramirez appeared to alter standing’s “concrete harm” requirement, which would significantly restrict plaintiffs’ ability to invoke the jurisdiction of federal district courts. Building off its 2016 case, Spokeo v. Robins, the Court declared that intangible harms are only concrete when “plaintiffs have identified a close historical or common-law analog[] for their asserted injury.” The “common-law analog[]” required a “close relationship to harms traditionally recognized as providing a basis for lawsuits in American courts.” The Court mandated this requirement …

Building Social Capital In Nonprofit Human Service Organizations, Glenn M. Birch

School of Professional and Continuing Studies Nonprofit Studies Capstone Projects

All forms of capital enhance the ability to accomplish tasks efficiently. Like physical, human, and financial capital, social capital enables individuals or organizations to accomplish more than is otherwise possible. When groups undertake actions to cooperate and achieve a shared purpose, it is a sign of social capital at work. This study looks specifically at human service nonprofit organizations to examine strategies and practices that can lead to the building of social capital. As a comparative case study of two nonprofit organizations, I explore how nonprofit organizations learn to build social capital across lines of difference; look at how bridging …

Navigating Neither, Susan S. Kuo

University of the Pacific Law Review

No abstract provided.

Osha Overreach: The Nondelegation Doctrine And The Strain On Small Businesses, Zachary Byrne

University of the Pacific Law Review

No abstract provided.

Algorithms, Images, And Authorship: Creating Copyright Criteria In The Age Of Ai-Assisted Imagery, Whitney Ellis

University of the Pacific Law Review

No abstract provided.