Digital Commons Network^™

Next Generation Sequencing Based Profiling Of Genes In Patients With Syndromic Forms Of Retinitis Pigmentosa, Harshavardhini G

Theses and Dissertations

India is one of the largest populations in the world and is estimated to have a high prevalence of Retinitis Pigmentosa (RP). RP is clinically and genetically heterogenous, characterized initially as night blindness, leading to complete vision loss due to retinal degeneration. RP can occur in non-syndromic or syndromic forms, affecting other organs as observed in Bardet Biedl Syndrome (BBS) and Usher syndrome (USH).

BBS is characterized by RP, polydactyly, obesity, renal anomalies and learning difficulties. USH is characterized by RP and sensorineural hearing loss (SNHL), with variable presence of vestibular dysfunction. Nextgeneration sequencing (NGS) has become a cost-effective technology …

Non-Compete Clauses Mysteriously Appearing Out Of Thin Air: The Catastrophic Flaws Of Inevitable Disclosure Doctrine In The New Ftc Non-Compete Rule And Beyond, Bradford P. Anderson

Southern Illinois University Law Journal

The Federal Trade Commission (FTC) recently adopted a new regulation that prohibits non-compete clauses for employees (Non-Compete Rule). Simultaneously, the FTC allowed the inevitable disclosure doctrine to continue in existence, even though such doctrine is tantamount to a non-compete clause. Under the inevitable disclosure doctrine, an employer posits that an employee will be unable to abide by her/his confidentiality obligations, and therefore unable to resist use and disclosure of proprietary information at an alternative employer. As a result, prescient, mind-reading judges portend future conduct under the inevitable disclosure doctrine and can issue an order banning or restricting future employment, thereby …

Falling In Love, Rebecca Bradbury

Psychology Student Publications

No abstract provided.

Scrolling Into Disorder: Social Media And Body Image, Anna Funk

Psychology Student Publications

No abstract provided.

Debtor's Reply To Trustee's Objection To Disclosure Statement

Catholic Dioceses in Bankruptcy

No abstract provided.

An Examination Of Academic Library Platforms And Systems During Covid-19, Cole Hudson, Paul Gallagher

University Libraries Faculty Publications and Presentations

This paper examines the use and subsequent trajectory of academic library technologies due to the impact of the COVID-19 pandemic. Taking a broad view of technologies, the systems and services discussed will center around resource use because COVID restrictions shuttered many in-person technologies. The two academic libraries compared in this study show a similar pattern of use and signal growth of certain platforms and technologies for the future.

Schools Apart: Curricular Stratification Across School Socioeconomic Compositions And Implications For Educational Inequality In The Us, Daniel Mackin Freeman

Dissertations and Theses

Motivated by longstanding sociological theories and utilizing the most current, large, and nationally representative data, this dissertation aims to describe and add nuance to our understanding of how the curriculum US youth are exposed to is stratified by the socioeconomic composition of the schools they attend. All three empirical chapters suggest that school SES contributes to substantial differences in school structure, as evidenced by differences in course-taking patterns and how course-taking relates to academic achievement in high school and beyond. The first study suggests that the relationship between curricular intensity in secondary school and postsecondary achievement is variable depending on …

Microstructure Analysis Of Different Naoh Molarity Towards Fly Ash Geopolymer For Underwater Concreting Material, F. H.A. Zaidi, A. Romisuhani, M. M.A.B. Abdullah, W. M.W. Ibrahim, M. I.A. Bistamam, A. S. Sauffi, L. Y. Li

School of Engineering, Computing and Mathematics

Geopolymer concrete is a new sustainable and environmentally friendly composite with great potential to replace conventional concrete that is mostly produced by ordinary Portland cement (OPC). Binders used for geopolymer concrete such as fly ash and blast furnaces are mostly industrial wastes or by -products containing high silica and aluminium content that act as stimulants for geopolymerization. Furthermore, geopolymers also exhibit better durability and corrosion resistance than OPCs. However, material subjected to underwater placement method typically exhibit a decrease in properties. While geopolymer has not been widely used as underwater concreting material, this research is purposed to identify the effect …

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Louisiana Law Review

No abstract provided.

How Media Representation Influences Disability Bias, Emilie Brend

Psychology Student Publications

No abstract provided.

Walking Towards Wellness, Madison Lyman

Psychology Student Publications

No abstract provided.

Portraits Of Agency And Power: Exploring Andean Women In Guamán Poma's Chronicle, Ruby Sygar

University Honors Theses

This study explores the depictions of women in Felipe Guamán Poma de Ayala’s chronicle titled, El primer nueva crónica y buen gobierno. By concentrating on six distinct portraits within this manuscript, the findings intend to reveal the themes, differences, and symbolic meanings that characterize and differentiate these representations. The analysis delves into how these portrayals provide insights into the roles, status, and societal perceptions of women in Inca society during the colonial period. The situation of these depictions within the general context of gender and colonialism in Andean society aims to showcase how nobleman Guamán Poma’s work critiques and …

Waves Of Change: A Call To Federally Safeguard Against Climate-Driven Floods, Trevor Johnson

Southern Illinois University Law Journal

The average flood event in the United States costs Americans $4.7 billion. Flood events have become more frequent, widespread, and of longer duration due to climate change. The United States attempts to combat the emerging threat of flooding through federal and private insurance programs. Still, as flooding risk rises, property owners are burdened by the responsibility to assess and prepare for these risks independently since standard homeowners’ and renters’ insurance does not cover flood damage under any circumstances in the United States. Rural communities are particularly vulnerable to the impacts of climate change due to economic foundations that are intricately …

Science Communication: What Are The Psychological Effects Of Keeping Secrets?, Sydney Rygg

Psychology Student Publications

No abstract provided.

Enhancing Communication And Swallowing Skills In Children With Cri Du Chat Syndrome: A Comprehensive Speech Therapy Guide, Soultana Papadopoulou, Areti Anagnostopoulou, Dimitra V. Katsarou, Kalliopi Megari, Efthymia Efthymiou, Alexandros Argyriadis, Georgios Kougioumtzis, Maria Theodoratou, Maria Sofologi, Agathi Argyriadi, Efterpi Pavlidou, Eugenia I. Toki

All Works

Background: A specific deletion on the short arm of chromosome 5 (5p) is the hallmark of the rare genetic syndrome called Cri du Chat Syndrome (CdCS). It causes severe difficulty with swallowing, speech, motor skills, and cognitive deficiencies. These arise from characteristic laryngeal abnormalities and oral–motor dysfunctions. Objective: This study aims to investigate the effectiveness of speech and language intervention in addressing the multifaceted challenges of CdCS, including speech and language impairments, feeding difficulties, and social communication deficits. Methods: A narrative review was conducted to synthesize existing studies from the last 35 years on therapeutic interventions for individuals with CdCS. …

Transcend, Anne Gregg

A Midwestern Review: A Magazine of the Arts and Issues at DePauw University

Anne Gregg is a junior English writing major, Honor Scholar, and Media Fellow at DePauw. She is also the Editor-In-Chief of A Midwestern Review. Recently she’s developed an interest in liminality, Pinterest mood boards, and cryptozoology. Contrary to popular belief, she is not young; she is ancient and rotting.

Levels Of Failure: How The United States’ Rendition, Detention, And Interrogation Program During The War On Terror Failed As Counterterrorism Policy, Maggie Carr

Washington Semester Program

No abstract provided.

Discharge-To-Water Level Conversion Using Monthly Duration Curves (Dwl-Mdc): Enhancing The Utility Of The Geoglows Ecmwf Hydrological Model, Darlly Judith Rojas Lesmes

Theses and Dissertations

Flood early warning systems are crucial for disaster risk reduction strategies, enabling communities to take timely action against threats. However, the effectiveness of these systems depends on accurate and timely hydrological data, particularly river discharge and water level measurements. Unfortunately, many regions, face significant challenges in obtaining hydrological data, especially discharge data due to outdated rating curves, high equipment costs, and logistical constraints. Water level measurements, by contrast, offer reduced uncertainty and are often more accessible, providing an alternative for hydrological modeling in data-scarce regions. To address these limitations, we developed and validated the Discharge-to-Water Level Conversion Using Monthly Duration …

Community, Service, And Growth: A Winant Fellow's Summer Of Impact, Bailey Schott

UNH Today Archive

No abstract provided.

Unilateral Hemicraniectomy With Titanium Cranioplasty For The Treatment Of High Intracranial Pressure In A Pediatric Patient With Camurati-Engelmann Disease: Illustrative Case, Roboan Guillen-Arguello, Nicholas Sader, J. Gordon Mccomb

School of Medicine Faculty Publications

BACKGROUND Camurati-Engelmann disease (CED) is an extremely rare autosomal dominant genetic disorder that can cause increased intracranial pressure (ICP) secondary to cranial hyperostosis, which decreases intracranial volume. Surgical procedures to reduce ICP in medically refractory cases include intracranial volume expansion and ventriculoperitoneal shunting. OBSERVATIONS The authors present the case of a pediatric patient with CED and medically refractory increased ICP who underwent unilateral hemicraniectomy with titanium cranioplasty, resulting in a complete long-term resolution of symptoms. LESSONS Unilateral hemicraniectomy with titanium cranioplasty is a feasible surgical treatment for CED in pediatric patients with medically refractory increased ICP and papilledema.

Innovations In Genicular Outcomes Registry (Igor): Protocol For A Real-World Registry Study Of Treatments For Knee Osteoarthritis, Vinod Dasa, William Mihalko, Adam Rivadeneyra, Joshua Urban, Andrew Wickline, David Rogenmoser, Andrew Concoff, Andrew Spitzer, Michael A. Mont

School of Medicine Faculty Publications

BACKGROUND: Osteoarthritis (OA) is the leading cause of disability among US adults and most commonly affects the knee. Guidelines for knee OA treatment include behavioral, nonpharmacological, pharmacological, and surgical interventions. While emerging knee OA treatments show promise for pain control, data gaps remain regarding the efficacy, safety, comparative effectiveness, and real-world value of treatments. OBJECTIVES: The Innovations in Genicular Outcomes Registry (IGOR) is prospectively collecting real-world data to assess clinical effectiveness, safety, health-related quality of life, and healthcare resource utilization of knee OA treatments. DESIGN: The IGOR is a prospective, observational, longitudinal, multicenter registry (NCT05495334) examining knee OA pain treatment …

The Health Profile Of Students And Teachers In Madrasah Al Ihsan, Kecamatan Ciparay, Kabupaten Bandung, Ellin Febrina, Irma E. Herawati, Indah S. Wahyuni, Aziiz M. Rusdianto, Rini Hendriani, Irma M. Puspitasari, Mutakin Mutakin, Eli Halimah, Sri A. Sumiwi, Jutti Levita

Pharmacology and Clinical Pharmacy Research

The prevalence of diabetes mellitus and hypertension in Indonesia is increasing both in low- and high-income communities. Therefore, health awareness should be started from a younger age for the prospective future generation. This study, included in a community engagement activity, aims to assess the health profile, in terms of blood pressure (BP) and total cholesterol, of the students (by cross-sectional method) and teachers (by cohort method) of a private madrasah in the rural area of Kecamatan Ciparay, Kabupaten Bandung, West Java. 54 students and 10 teachers participated in this study. Results revealed that the students' average systolic and diastolic BP …

Whispers In The Wind: Face Mask Sampling For Mycobacterium Tuberculosis Detection In Children With Pulmonary Tuberculosis, Stela Kulciţkaia, Viola Dreyer, Doris Hillemann, Qiniso Dlamini, Caroline Williams, Michael Barer, Folke Brinkmann, Renate Krüger, Stephanie Thee, Alexander Kay, Anna Maria Mandalakas, Christoph Lange

Faculty, Staff and Students Publications

Background: Recently, face mask sampling (FMS) confirmed detection of Mycobacterium tuberculosis DNA from exhaled breath in adults with tuberculosis. To date, no study has evaluated the use of FMS to detect pulmonary tuberculosis in children. We developed a method for FMS of M. tuberculosis-specific DNA in children and performed a clinical exploration to assess feasibility in children.

Methods: Face masks were spiked, analyzed on GeneXpert-Ultra, quantitative polymerase chain reaction, and targeted next-generation sequencing. Children with pulmonary tuberculosis were asked to wear 3 modified FFP2 masks for 30 minutes as part of an exploratory clinical study.

Results: Experiments with H37Ra M. …

Utility Of Immobilized Metal Salens As Electrocatalysts: Fuel Cells And Organic Electrosynthesis, Zachary A. Nguyen, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

There have been significant advancements in the electrosynthesis of fuels and organic molecules, making it an increasingly sustainable and cost-effective alternative to traditional chemical redox reagents. Early versions of these systems faced challenges in chemo selectivity due to high applied overpotentials, which have been mitigated with the introduction of molecular electrocatalysts, like metal salens (MSalens). These MSalens reduce the required overpotentials, increase turnover numbers (TON), and have simple modularity within their ligand structure allowing for tunable selectivity. While these MSalen electrocatalysts are typically used homogeneously for engineering simplicity, downstream separations are often costly and time-consuming. Immobilization of MSalens addresses these …

International Engagement Newsletter, December 16, 2024, University Of Northern Iowa. Office Of International Engagement.

Office of International Engagement newsletter

In this issue:

--- Winter Break Hours
--- Immigration Updates
--- Winter Break Reminders
--- Breakfast at Threehouse

Jessy Mckee And Shayne Mackee, Appellants V. Clayton Mckeachine, Carolyn Harns, G&C Servi Es Inc., And Irene Mckee, Appellees : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from the Order of Permanent Appointment of Limited Guardian and Full Conservator of Incapacitated Persons entered on August 10, 2023 by the Honorable Gregory Lamb, Eighth Judicial District Court, in and for Uintah County, State of Utah, Case No. 21380083.

Alan Dunaway, Attorney for Appellant, Clayton Mckeachnie, Pro Se Appellee, Kurt D. Reber, Attorneys for Appellee G&C Services, Inc

Kenneth J. Melrose, Attorney for Appellee Irene McKee, Deborah R. Chandler, Attorney for Christine DeLambert

Phosphorus Buffering Determines How Soil Properties And Rainfall Influence Wheat (Triticum Aestivum) Yield Response To Phosphorus Fertiliser, Craig Scanlan, Raj Malik, Gustavo Boitt, Mark Gherardi, James Easton, Zed Rengel

Grain and Other Field Crops Research Articles

Context

Current decision support systems (DSS) for phosphorus (P) fertiliser were developed using data from historical cropping systems. An understanding of how soil properties and rainfall influence wheat (Triticum aestivum) response to P fertiliser in current systems is required to optimise P management. Aims

The aims of this study were to: (1) assess the soil properties that have the greatest influence on relative yield; (2) examine how rainfall conditions influence relative yield; and (3) examine whether there were interactive effects between rainfall and soil properties on relative yield. Methods

Forty P rate-response field experiments were completed in Western …

Maria Castlen Art 399 Portfolio, Maria Castlen

Professional Practices (ART 399)

Often, I find myself following the mindset of “go, go, go”. I get caught up in the rush and chaos of the world. The bold, stimulating designs that are prevalent today further feed into the need to constantly to keep busy. To counter this, I like to bring a little bit of the past into my designs. I see it as a throwback to a time when things were simpler. Whether it be through the font, color palette, or illustration style, I embrace the chance to use a blast from the past.

I create designs that find the medium between …

Testing Routine Activity Theory: Behavioural Pathways Linking Temperature To Crime, Christopher Thomas, Jinuk Jeong, Kevin T. Wolff

Publications and Research

This study examines direct observations of outdoor routine activities to investigate the pathways through which temperatures shape crime. Daily administrative records of crime, weather, and outdoor activity were assembled from 2015 to 2019 in New York City. Mediation analysis (with bootstrapped standard errors) reveals that alterations in routine activities account for a statistically significant, yet modest, proportion of temperature’s relationship with homicides, shootings, assaults, larceny, and public consumption violations. The comparable mediation effects across violent and nonviolent crimes support routine activity theory as an explanatory framework for understanding temperature's impact on crime. The measures introduced here offer a novel approach …

Innovations In Educational Research: Developing An Original Questionnaire To Measure New Mexico’S Teacher Practices And Beliefs Related To Project-Based Learning And Culturally And Linguistically Responsive Teaching, Zachary R. Ramsey

Teacher Education, Educational Leadership & Policy ETDs

This dissertation investigates teacher practices and beliefs related to project-based learning (PBL) and culturally and linguistically responsive teaching (CLRT), central to New Mexico’s educational reform efforts following Martinez & Yazzie v. New Mexico (2018). The study also explored teachers’ professional learning needs and their awareness of the state’s reform initiatives. I collected responses from 37 participants using an original questionnaire instrument. While the findings are not generalizable, they reveal that teachers practiced elements of PBL and CLRT with moderate frequency and generally believed in their efficacy for improving educational outcomes for diverse student groups. The results also highlighted varying levels …