Digital Commons Network^™

Biphasic Sleep Is A Feature Of Sleep Disturbance In Syngap1-Rd, Aida Doucoure, Het Patel, Mark A Abboud, Alice Sperry, Sarah K Wanigatunga, Deana Crocetti, Heather Volk, Adam P Spira, Stewart H Mostofsky, Vaishnav Krishnan, Constance Smith-Hicks

Faculty, Staff and Students Publications

Study objectives: Sleep problems are common in children with SYNGAP1-Related Disorder (SYNGAP1-RD). The use of devices that objectively estimate sleep are complicated by co-occurring sensory disorders in this population. We examined the feasibility and validity of wrist actigraphy to examine sleep and rest-activity rhythms (RAR).

Methods: Data from five children with SYNGAP1-RD and 42 typically developing children were analyzed. All children were asked to wear the Actiwatch-2 for 14 continuous days and caregivers were asked to complete a sleep diary and the Children Sleep Health Questionnaire (CSHQ). Parametric (alpha, beta, acrophase, amplitude, up/down mesor, mesor), nonparametric (intradaily variability, interdaily stability, …

Herbaceous Plants In Forest Ecosystems: One Hundred Fundamental And Applied Questions, Harikrishnan Venugopalan Nair Radhamoni, Michelle Elise Spicer, Marlyse C. Duguid, Liza S. Comita, Emilio Bruna, Andrew J. Andrade, Julia I. Burton

Michigan Tech Publications

Aims: Herbaceous plants (herbs) found in the understory of forests contribute substantially to the biodiversity of these ecosystems, as well as being important socio-culturally, economically, and for advancing ecological theory. However, the ecology of herbs is less well understood compared with woody plants, despite evidence that herbs are physiologically and ecologically different. Similarly, herb research has focused on north temperate forests, with less information from forests in the tropics and Global South. Understanding this knowledge gap, and recognizing the critical importance of expanding and streamlining the scope of research on forest herbs, we set out to identify 100 fundamental and …

Longitudinal And Cross-Sectional Evidence That Daily Resting And Activity Energy Expenditures Are Independent In Humans, Andrew K Yegian, Elizabeth Pachus, Leanne M Redman, Steven B Heymsfield, K Falkenhain, Alexandra R Harris, Shaji K Chacko, William W Wong, Daniel E Lieberman

Faculty, Staff and Students Publications

Total energy expenditure (TEE) is commonly modelled as the sum of resting energy expenditure (REE), activity energy expenditure (AEE), and diet-induced thermogenesis (DIT). This additive model has recently been challenged by the constrained energy balance model, which proposes that reductions in mass-adjusted REE compensate to some extent for increases in AEE, rendering mass-adjusted TEE effectively invariant. We tested these competing models using two complementary approaches. First, we conducted a short-term longitudinal, repeated-measures experiment in 12 adults who completed 10-day periods of high and low physical activity separated by a washout period. TEE was measured with doubly labelled water, AEE with …

Na-Gst-1 Adsorbed On Alhydrogel Co-Administered With Different Toll-Like Receptor Agonists In Hookworm-Naive Adults Using A Controlled Human Infection Model In The Usa: A Phase 2, Double-Blind, Randomised Controlled Trial, Caroline K Dirosato, Elissa M Malkin, Sean M Lee, Guacyara Erwin, Lara Hoeweler, Larissa Scholte, Maria Elena Bottazzi, David I Pritchard, Peter J Hotez, Jeffrey M Bethony, David J Diemert

Faculty, Staff and Students Publications

Background: Necator americanus glutathione S-transferase-1 (Na-GST-1) performs a crucial enzymatic step in hookworm blood feeding and is a leading target for vaccine development. Phase 1 trials in Brazil, Gabon, and the USA of recombinant Na-GST-1 adsorbed on Alhydrogel (Na-GST-1/Al), co-administered with or without AP 10-701 (Toll-like receptor [TLR] 4 agonist) or CpG 10104 (TLR9 agonist), showed the vaccine was well tolerated, safe, and immunogenic. A controlled human hookworm infection (CHHI) model was previously developed to evaluate the effect of candidate hookworm vaccines on infection. We aimed to assess the effect of vaccination with three different Na-GST-1 vaccine formulations on subsequent …

A Nationwide Central Diagnosis For Pediatric Cns Tumors In Japan: The Jccg Brain Tumor And Pathology Committees, Yoshiko Nakano, Junko Hirato, Takako Yoshioka, Tetsuya Takimoto, Sumihito Nobusawa, Kaishi Satomi, Ran Tomomasa, Seiji Yamada, Taku Homma, Shoh Sasaki, Ayako Yamazaki, Maki Sakaguchi, Yasuhide Takeuchi, Nei Fukazawa, Kai Yamasaki, Kohei Fukuoka, Yui Shinohara Kimura, Yuki Nagayama, Yohei Inoue, Akira Miyahira, Ema Yoshioka, Asako Katsuma, Hayato Fukusumi, Tomoko Shofuda, Yuko Hibiya, Yuko Matsushita, Mai Honda Kitahara, Yuki Yomoda, Miho Kato, Michael D Taylor, Yasuhito Arai, Tatsuhiro Shibata, Hiroaki Sakamoto, Keita Terashima, Yoshiki Arakawa, Toshihiro Kumabe, Ryo Nishikawa, Junichi Hara, Yonehiro Kanemura, Koichi Ichimura

Faculty, Staff and Students Publications

In 2016, the Japan Children's Cancer Group launched a nationwide research initiative to provide central diagnosis incorporating pathology review and molecular profiling for pediatric central nervous system (CNS) tumors. Over the first eight years, 2224 cases were registered. Non-next-generation sequencing analyzes, such as pyrosequencing and NanoString, were routinely performed, mainly for glioma, medulloblastoma, and ependymoma. Additional analyzes, including methylation profiling and RNA sequencing, were conducted for selected diagnostically challenging cases. The most common diagnoses were low-grade glioma (26%), medulloblastoma (18%), germ cell tumor (16%), high-grade glioma (12%), and ependymoma (11%). Diagnostic or targetable alterations were detected in nearly half of …

Deporting Disability, Tania N. Valdez

Utah Law Review

Since the enactment of the earliest migration laws in the United States, people with disabilities have been targeted for exclusion and expulsion based on stereotypes that they are either dangerous or not productive. Although some of the pejorative language regarding disability in the Immigration and Nationality Act (INA) has changed over time, certain statutory provisions and the very structure of the INA still allow ableism to operate broadly in immigration adjudications. This Article focuses on the subtle, but pervasive, ways that immigration law disfavors noncitizens with disabilities. In particular, this Article examines ableism in the context of removal (commonly known …

Puhca 2.0, Joshua C. Macey

Utah Law Review

Many electric utilities today are vertically integrated and own both rate regulated (transmission and distribution) and competitive (generation) affiliates. This structure gives them incentives to make investments that favor their affiliated generators and shift risk onto captive ratepayers. The Federal Energy Regulatory Commission (FERC) and state public utility commissions have adopted a variety of rules to address these concerns, including limits on affiliate transactions and functional unbundling requirements. Unfortunately, these requirements have failed to prevent utilities from using their control over grid infrastructure to benefit affiliates that participate in competitive markets.

This Article therefore calls for a structural solution: a …

Learning From Lochner: When Children Are Harmed By Technological Revolutions, Brooke Hodson Davies

Utah Law Review

Drawing on parallels from child labor reform in the Second Industrial Revolution, this Note argues that stopping Big Tech’s harm to children in the Fourth Industrial Revolution requires Congressional legislation and judicial avoidance of Lochnerian approaches to the Constitution. Like its Big Business predecessors, today Big Tech maximizes profits by harming kids, necessitating government intervention of this market failure. Despite noble attempts, state-based efforts have been rendered relatively ineffective due to legislative non-uniformity, interstate competition, and enforcement limitations. Likewise, federal regulations currently in place fall short and even shield Big Tech from liability. Consequently, Congressional action is urgently needed. Critically, …

Taking The Thumb Off The Scale: Rebalancing Parental And Children’S Rights To Empower Child Protective Services, Sebastian Wagner

Utah Law Review

This Note provides background on the current legal framework of state prevention of child maltreatment in the United States. It discusses parental rights and the Parental Rights Doctrine, child rights in the United States, and how states prevent child maltreatment through child protective service agencies.

This Note also explores the legal landscape surrounding the balance of parental rights and children’s rights in child welfare cases. One of the central issues in the current framework is how the Parental Rights Doctrine can significantly limit the state’s ability to intervene in cases where children are at risk. State intervention, governed by vague …

Blinded, Bias-Controlled Multi-Rater Evaluation Of Human-Versus-Ai Brain Metastasis Segmentation Using A Hybrid Foundation-Model Framework, Yiding Han, Enze Zhu, Mhd Hasan Ai Mekdash, Omar Awad, Piyush Pathak, Shixiao Liang, Daniel Allan Hamstra, Xizhe Zhang, Zaid Ali Siddiqui, Baozhou Sun

Faculty, Staff and Students Publications

Background: Accurate segmentation of brain metastases (BM) is essential for diagnosis, stereotactic radiosurgery planning, and longitudinal assessment. However, manual contouring is time-intensive, limiting clinical scalability, and exhibits substantial inter-observer variability. This variability complicates objective assessment of automated segmentation methods and challenges interpretation of model performance.

Purpose: To address these limitations, we developed TUM-SAM, a hybrid foundation-model framework for fully automated BM segmentation, and introduced a bias-controlled, blinded multi-rater evaluation paradigm to determine whether AI-based BM segmentation has reached expert-level performance and whether AI-generated contours are preferred by human experts under unbiased assessment.

Methods: TUM-SAM integrates nnU-Net-based lesion detection with a …

Adlm Guidance Document On Incorporating Gender Diversity In Pathology And Laboratory Medicine, Tiffany A Thomas, Gabrielle N Winston-Mcpherson, Ina Amarillo, Alisha D Berry, Caroline J Davidge-Pitts, Sridevi Devaraj, Zil Goldstein, Brad S Karon, Brooke M Katzman, Mahmoud A Khalifa, Hung S Luu, James H Nichols, Tracy L Stockley, Michelle R Stoffel, Dina N Greene, Matthew D Krasowski

Faculty, Staff and Students Publications

Background: The first international clinical standards of care for the gender-diverse population were formulated in the late 1970s. In the last 15 years, multiple subspecialty societies within the United States have developed clinical care guidelines for those with gender dysphoria, including gender-affirming hormone therapy (GAHT) and surgical treatments. To date, there are no pathology- and laboratory medicine-specific recommendations in the United States for the gender-diverse population.

Content: This document outlines pathology- and laboratory medicine-specific recommendations for providing optimal care to the gender-diverse population, with a predominant focus on the adult population. The scope of this document focuses on the following …

Performance Of Fecal Calprotectin And Serum Procalcitonin For The Diagnosis Of Spontaneous Bacterial Peritonitis In Patients With Cirrhosis: A Prospective Diagnostic Accuracy Study, Mandip Singh Bhatia, Devarakonda Uday Teja, Nipun Verma, Archana Angrup, Saurabh Chandrabhan Sharda

Faculty, Staff and Students Publications

Background:: Spontaneous bacterial peritonitis (SBP) is a life-threatening complication in patients with cirrhosis and ascites. This study aimed to evaluate the diagnostic performance of biomarkers—calprotectin (serum, ascitic, fecal) and serum procalcitonin (PCT)—for SBP.

Methods:: This prospective diagnostic accuracy study, enrolled 137 consecutive patients with cirrhosis and ascites at a tertiary care center in India. Participants were categorized into SBP (n = 55) and non-SBP (n = 82) groups based on the reference standard of ascitic fluid neutrophil count. Serum, ascitic fluid, and fecal calprotectin were measured by enzyme-linked immunosorbent assay, and serum PCT was measured by electrochemiluminescence immunoassay. …

Nascent Titanium-/Silicon-Containing Particle Formation In Corona-Discharge-Assisted Combustion, Chanakya Bagya Ramesh, Frank Daoru Han, Yang Wang

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Adding plasmas to a flame has been shown to introduce high concentrations of charges, ions, and radicals to the said flame. This technique of adding plasma to a flame is called plasma-assisted combustion (PAC), and this addition has been shown to make a flame more stable and efficient. At the same time, PAC has also been shown to alter particle formation during combustion. Here, we investigate the effect of a high-frequency (∼21 kHz) alternating current (AC) corona discharge on particle formation and growth in a premixed flame, especially at the initial stages (with particle sizes below 10 nm). We first …

Reimagining International Investment Law For The Age Of Minerals, Taylor Nchako

Washington and Lee Law Review

New technologies––from artificial intelligence (AI) and electric vehicles to medical devices and consumer electronics––demand an ever-increasing amount of minerals like lithium, cobalt, and copper. The United States requires these aptly named “critical” minerals to develop AI infrastructure, advance the clean energy transition, and remain economically competitive. As technology continues to advance at an astonishing pace, the U.S. has grown increasingly interested in securing critical minerals from sources in Africa. To obtain critical minerals, the U.S. must utilize investment treaties in its business dealings with African countries. At the same time, international investment law has garnered increased attention due to a …

Fur, Feathers, And Frameworks: The Federal Legal Landscape Of Animal Welfare In The United States And Switzerland, Michael Melch

Washington and Lee Law Review

The United States relies on a predominantly utilitarian, welfarist framework that regulates certain uses of animals while preserving their status as property. Switzerland embeds the concept of animal dignity in its constitutional and statutory law, formally recognizing animals as beings with intrinsic worth. This foundational divergence produces significant doctrinal and practical differences, including the breadth of species covered, the structure of legal obligations, and the normative goals of regulation.

This Note provides a comparative analysis of animal welfare laws in the United States and Switzerland, exploring their philosophical, legal, and practical dimensions. It examines the U.S.’s utilitarian approach, exemplified by …

Litigating The Youth Mental Health Crisis: Mechanisms To Regulate Addictive Social Media Design, Talia Elliott

Washington and Lee Law Review

While social media offers real benefits to users, such as providing access to information and facilitating the free exchange of ideas, excessive social media use is associated with increases in anxiety, depression, and other serious mental-health harms. Social media platforms are designed to maximize profit by capturing user attention, resulting in interfaces that are dangerously addictive and prone to exposing users to harmful content. Currently, social media users alone bear the burden of navigating the dangers of social media. This is untenable. Young users, whose less developed brains leave them more vulnerable to addictive design features, find self-regulation especially challenging. …

Compact Cislunar Orbital Representation For Efficient Tracking In Cislunar Space, Mauro Palomo

Doctoral Dissertations and Master's Theses

Expanding lunar missions require efficient, interoperable orbital tracking where existing methods fail to scale. Two-Line Elements (TLEs) lack applicability beyond geocentric regimes, while high-accuracy Orbit Ephemeris Messages (OEMs) require excessive data volumes and bandwidth to communicate. To support increased lunar traffic, this paper proposes the Compact Cislunar Orbital Representation (CCOR), providing a novel framework that strikes a balance between TLE level efficiency and OEM-level fidelity, ensuring multi-actor communication for missions in the cislunar region. By evaluating the framework across six diverse cislunar trajectories, this study demonstrates the CCOR’s robustness and ability to compress thousands of OEM state vectors into a …

Experimental-Motion-Driven Cfd Investigation Of Slosh Dynamics In Propellant Tanks Of Spacecraft And Launch Vehicles, Priyanshu Savaliya

Doctoral Dissertations and Master's Theses

Liquid sloshing in partially filled propellant tanks can generate transient forces and moments that affect spacecraft and launch vehicle stability, guidance, and control. This research develops a one-way experimental-to-Computational Fluid Dynamics (CFD) integration framework to investigate free-surface slosh behavior under realistic excitation conditions.

The overarching goal of this thesis is to develop and evaluate a one-way experimental-motion-driven computational framework for predicting liquid slosh response in a partially filled cylindrical tank. Rather than relying on idealized sinusoidal inputs, this work uses experimentally measured actuator-feedback motion as the prescribed excitation for high-fidelity CFD. The central objective is to establish the experimental and …

Online Ppo-Based Multi-Hop Task Offloading Strategy For Vehicular Edge Computing, Wenzhu Zhang, Yuewei Bian, Fuli Xiong, Siqi Cai

Journal of System Simulation

Abstract: To address the problems of frequent communication link interruptions caused by dynamic network topologies and the sharp increase in computational complexity triggered by high-dimensional decision spaces in the vehicular edge computing (VEC) environment, a multi-hop task offloading strategy for VEC based on an online PPO algorithm was proposed. A multi-hop task offloading optimization model simultaneously considering link effective time, transmission rate, and computing resource constraints was constructed; a multi-hop A* path search algorithm integrating link stability and end-to-end delay was designed; an online offloading decision framework based on PPO was proposed, which transformed the 0-1 mixed integer nonlinear programming …

Research On Temporal Action Localization Methods For Cross-Modal Understanding, Jinwei Li, Xiaoyang Liu, Rusheng Ju

Journal of System Simulation

Abstract: To address the problems of insufficient localization accuracy and high model complexity in the temporal action localization (TAL) task for video-text cross-modal understanding, an anchor-free action transformer (AFAT) model was proposed. Based on the anchor-free framework, the local self-attention mechanism of Transformer was introduced to enhance the global modeling capability of temporal features. A multi-scale feature pyramid structure was combined to strengthen the representation of actions with different durations, and a lightweight predictor was adopted to reduce computational redundancy. Experimental results show that the average precision of this model on the THUMOS14 dataset is significantly improved compared with the …

“Retalhos De Mim Costurados Por Nós” (A Patchwork Of Me, Stitched Together By Us), Marjorye Graves

MFA in Dance Theses

This document represents the culmination of my thesis project "Retalhos de Mim Costurados por Nós" (A Patchwork of Me, Stitched Together by Us), a choreographic project integrating scholarly perspectives from Dance and Social Justice, Phenomenology, and Somatics courses. Employing both dance film and solo live performance, the research interrogates the complexities of identity within the overlapping contexts of immigration, domestic violence, and motherhood. Through an embodied praxis, the project addresses the intersection of adversity and resilience, highlighting the transformative potential of community, cultural inheritance, and spirituality in my healing process.

Fundamental Uncertainties Invalidate The Precision Of Obsidian Hydration Dating: A Rapa Nui Case Study, Robert Dinapoli, Carl P. Lipo

Anthropology Datasets

Obsidian hydration dating (OHD) measures water absorption into volcanic glass to estimate artifact age. Recent studies using infrared photoacoustic spectroscopy (IR-PAS) claim ±30-year precision, comparable to radiocarbon dating. We tested these claims by applying Bayesian hierarchical models to 242 published IR-PAS measurements from Rapa Nui (Easter Island). Standard OHD practice treats burial temperature and humidity as known constants; we instead modeled them as uncertain variables and propagated that uncertainty through the rate equation. Realistic dating uncertainties are ±300 years, ten times larger than the claimed value. The 95% credible interval for any individual date (~600 years) exceeds Rapa Nui's entire …

Beyond Ai Detection: A Pilot Study Of Integrevise And Viva-Based Verification Of Student Understanding In Ai-Mediated Assessment, James Hutson, Kyle Poyer, Kelvin Adshola Atologun

Faculty Scholarship

This article examines the Integrevise platform through a repeated cross-sectional, multicycle pilot case study of viva-based verification in AI-mediated assessment environments. Integrevise pairs a submitted written artifact with a short adaptive viva in which students explain their work, reasoning, and application in their own words. Rather than functioning as an AI detector or automated grading system, the platform operates as a diagnostic assessment layer intended to surface comprehension, authorship confidence, and disengagement risk before final grades become the only available signal. The pilot was conducted across Fall 2025 and Spring 2026 at a private liberal arts college in the Midwest; …

Voices Unheard: A Phenomenological Study Of Access And Inclusion Of College Students With Autism In The Southeastern United States, Janet L. Kuchinski

Dissertations

Although access to higher education has expanded for students with autism spectrum disorder (ASD), many continue to encounter barriers to meaningful inclusion, belonging, and participation within the college environment. The purpose of this interpretative phenomenological analysis (IPA) study was to explore the lived experiences of college students with ASD regarding access and inclusion in higher education. Purposeful sampling was used to recruit five college students with ASD who were at least 19 years of age, currently enrolled in college, and registered with disability services. Data were collected through semi-structured interviews conducted via Microsoft Teams and analyzed using established IPA procedures. …

Alfred Russel Wallace Notes 41. Violet Wallace’S ‘Natural History For Infants’, Charles H. Smith

Faculty/Staff Personal Papers

In 1893 Violet Wallace (1869-1945), daughter of Alfred Russel Wallace (1823-1913), published a serialized work entitled ‘Natural History for Infants’.

Adjustment Challenges In The International Student Population At A Rural Mid-Size Midwestern University, Sara El Bizri Hussein

All NMU Master's Theses

This qualitative descriptive study explored the adjustment experiences of non-athlete international students attending a rural, mid-size Midwestern university and identified the challenges and supports that shaped their transition.

Guided by Berry’s acculturation framework and informed by theories of student integration and coping, data were collected through an initial survey and semi-structured interviews. Seven participants were interviewed. Interview transcripts were analyzed using open and focused coding procedures to identify recurring patterns and themes.

Analysis revealed that international student adjustment is multidimensional and influenced by social, academic, emotional, cultural, environmental, and structural factors. Three major themes emerged from the data: (1) Social …

Using Zebrafish To Investigate The Innate Immune Response To R132h Mutant Glioma, Mikaela L. Fairbanks

All NMU Master's Theses

Gliomas are the most commonly occurring brain tumor found in adults. The most dominant mutation found in glioma is in the isocitrate dehydrogenase 1 (IDH1) gene. IDH converts isocitrate into α-ketoglutarate (α-KG), but the mutated form of it will take α-KG and further convert it into D-2-hydroxyglutarate (D-2-HG). Mutated IDH1 glioma (mIDH1) produces a higher concentration of D-2-HG than the wild-type IDH1 glioblastoma (wtIDH1). These mIDH1 tumors tend to have a better prognosis, growing slower and having less inflammation than the wtIDH1 counterpart, potentially due to the increased D-2-HG. However, the effects of mIDH1 and D-2-HG on the innate immune …

Assessing The Relationship Between The Degree Of Static And Dynamic Quadricep Angle And Kinetic Asymmetry Index % In Females During The Follicular Phase Of Menstruation, Madeline Grace Poirier

All NMU Master's Theses

The quadriceps angle (q-angle) quantifies lateral pull on the knee. Females have greater static and dynamic q-angles due to anatomical factors including a wider pelvis and more lateral tibial tuberosity, which may influence ACL injury risk. The kinetic asymmetry index (KAI %) measures limb-to-limb differences in ground reaction force (GRF) impulses during dynamic tasks including countermovement jumps (CMJs), with values > 10% linked to injury risk. During the follicular phase of the menstrual cycle, fluctuating hormones increase joint laxity, further heightening biomechanical vulnerability in females.

This cross-sectional study examined the relationship between static and dynamic q-angle and KAI % in active, …

Developing Solvent-Based Recycling Methods At Ambient Conditions To Regenerate Bisphenol A Diglycidyl Ether And Recover Metal Oxides From Epoxy Nanocomposites, Heaven Smith

Rose-Hulman Undergraduate Research Publications

No abstract provided.

Highly Confident But Slightly Uncertain: A Long Overdue Reinvention Of The School Scientific Method, Teaching - Volume 4, Stephen Demeo

Publications and Research

In Volume 4, the last book of the series, I continue the argument for greater parity between conceptual knowledge—the "what" of science—and methodological knowledge—the "how" of science—but in the context of teacher instruction. To this end, two literature reviews are presented: One on how students build confidence, specifically regarding the reliability or consistency of measurement or results, and the other on scientific uncertainty. Research studies focusing on student misconceptions are summarized and organized from the elementary to the college level. These literature reviews describe invaluable ways for teachers to improve their instruction, while providing examples of experiments that can be …