Digital Commons Network^™

Biophysical Insights Into A Cryptic Ligand Site In The Hydrophobic Core Of Human Pcna, Alexis N. Dispensa, Sharon N, Greenwood, Jason Yang, Daniel E. Logatto, James Fusco, E. Railey White, Roderic G. Eckenhoff, Zhiwei Liu, Brian P. Weiser

Department of Anesthesiology Faculty Papers

Proteins contain small pockets that form due to imperfections in residue packing or the rotational and conformational movement of amino acids. In this work, we used the fluorescent probe 1-aminoanthracene (AMA) to detect a small ligand pocket in the hydrophobic core of human proliferating cell nuclear antigen (PCNA), which is a critical protein for DNA replication and repair. Fluorescence measurements of AMA reported that the core of PCNA had a dielectric constant (ε) of 4, which was very apolar and similar to cyclohexane (ε = 2). Protein mutagenesis, photoaffinity labeling, and molecular dynamics simulations localized the binding site for AMA …

Psychotropic Medication Use In Older Adults In A Long-Term Care Facility: Implications For Screening Tool, Callie M. Johnson

Dissertations

Psychotropic medication use in older adults aged 65 years and older residing in the long-term care facility has a complex issue in the high use of psychotropic medications. Older adults residing  in long-term care (LTC) facilities are affected and prescribed at least one psychotropic or antidepressant medication.

Enhancing Well-Being: Implementing Weekly Social Interventions For Older Adults In Independent Living, Rosa Huang

Dissertations

Loneliness and social isolation significantly impact the physical and mental well-being of older adults. This quality improvement project implemented an eight-week social intervention designed to reduce loneliness and enhance well-being through weekly sessions incorporating mindfulness exercises, gratitude journaling, and structured socialization activities. The intervention was delivered by nursing students to a sample of residents in a Midwestern independent living community. While most standardized measures of loneliness and mood did not show statistically significant changes, the project resulted in a statistically significant increase in social network engagement as measured by the Lubben Social Network Scale-6 (LSNS-6). The findings suggest that group-based …

Fostering Active Learning In Reproductive Health Classes Among Undergraduates Of A Nigerian Public University: The Role Of Cognitive Restructuring Health Education, Ndubuisi Friday Ugwu, Adewumi Segun Igbinlade, Adijat Bolanle Adams, Uchenna Anselm Anibueze, Gabriel Aderibigbe Oyegbami, Chinyere Chrysantus Onwurah, Sabina Nwakaego Igwilo, Olufemi M. Olubamise, Folasade Adediran, Oladipo Adeyeye Olubodun Phd, Jacob Kehinde Opele, Loveth Nnenna Ugwu, Amos Olorunwa Agbojo

Higher Learning Research Communications

Objective: This study examined the efficacy of the cognitive restructuring health education (CRHE) intervention in improving participatory learning in sexual and reproductive health classes among students at a Nigerian public university.

Methods: The study employed a randomized pretest/posttest control group design involving 130 undergraduates from Federal University Oye-Ekiti, Nigeria. Participants were randomly assigned to either a 2-week intensive health education–based cognitive restructuring program (n = 65) or a waitlist control group (n = 65). Interaction behavior was assessed at pretreatment, at post-treatment, and at a 6-week follow-up using the 14-item Interaction Behavior Checklist (reliability = 0.85). …

[Excerpt From] The Nurse Manager's Guide To Budgeting & Finance, 4th Edition, Annmarie Papa

Sigma Publications: Book Excerpts

Nurses focus on the art and science of caregiving, so stepping into a nurse manager role brings new challenges—especially when it comes to the economic reality of patient-staffing ratios, budgets, reports, accounting, and financial decision-making. Acronyms such as FTEs and ADCs can feel like a foreign language, but thankfully, this book is here to help. The Nurse Manager’s Guide to Budgeting and Finance, 4th Edition, provides real-world tools, tips, and strategies nurses need to manage resources wisely, support their team, and keep their unit on track in an increasingly complex healthcare environment. In this practical, on-the-job handbook, author AnnMarie Papa …

Vocabulary Acquisition Through Developmental Play, Amy Storlie

Graduate Teacher Education

As the population of English learners in the United States grew, there was a greater need for linguistically and developmentally appropriate instructional approaches for young learners. The question that guided this research on appropriate instructional approaches was: How does developmental play support the acquisition of academic vocabulary among early-emergent multilingual students in kindergarten and first grade? The research review examined peer-reviewed research across three interconnected bodies of literature: play-based learning, interactions in developmental play, and vocabulary instruction. The findings indicated that purposeful, guided play strengthened executive function, expressive language, and academic growth. In addition, collaborative practices such as translanguaging supported …

Tau Pathology In Epilepsy: Emerging Mechanisms And Translational Opportunities, Arjune Sen, Xin You Tai, Aristea Galanopoulou, Maria Thom, Eleonora Aronica, Lucy Vivash, Martin Hardmeier, Action Amos, Stephan Rueegg, Matthias Koepp, Yaroslav Winter, Christoph Helmstaedter, Jeffrey L Noebels, Hilal A Lashuel, Terence J O'Brien

Faculty, Staff and Students Publications

The onset of epilepsy in adulthood occurs most commonly after 55 years of age. Given the ageing global population, this disorder represents an increasing burden on healthcare and society. The bidirectional link between epilepsy and dementia is a focus of intense research with underlying tau pathology highlighted as a potential mechanistic link. In this review, we examine the evidence for tau-related neurodegenerative processes in epilepsy beginning with how changes in biochemical and structural properties of the tau protein can lead to abnormal phosphorylation and pathological aggregation. We consider the role of tau in seizure occurrence and cognitive difficulties in experimental …

Extrafloral Nectaries In Woody Plants: Toward An Integrated Framework For Ant-Mediated Plant Defense, Fangming Liu, Qifei Cai, Victor Busov, Zhen Liu

Michigan Tech Publications

Extrafloral nectaries (EFNs)-secretory structures that recruit predatory arthropods as indirect defenders against herbivory-have been studied almost exclusively in herbaceous systems, leaving a critical gap in our understanding of plant defense in woody plants. In trees, secondary growth, ontogenetic regulation, and seasonal phenology generate structural and temporal heterogeneity in EFN expression poorly captured by existing frameworks. We synthesize evidence across structural, chemical, and functional dimensions of EFN biology to develop an integrated framework for perennial trees. Our analysis suggests that methodological limitations in EFN detection likely bias the current chemical record of woody EFNs, while incomplete chemical characterization constrains the evaluation …

Narrowband Searches For Continuous Gravitational Waves From Known Pulsars In The First Two Parts Of The Fourth Ligo–Virgo–Kagra Observing Run, The Ligo Scientific Collaboration, The Virgo Collaboration, The Kagra Collaboration, Marc Favata, Shoan Ghosh, Rodica M. Martin

Department of Physics and Astronomy Faculty Scholarship and Creative Works

Rotating nonaxisymmetric neutron stars (NSs) are promising sources for continuous gravitational waves (CWs). CWs may, if detected, inform us about the internal structure and equation of state of NSs. Here, we present a narrowband search for CWs from known pulsars, for which a matched-filter search can be applied. Narrowband searches are robust to mismatches between electromagnetic (EM) and gravitational emissions, in contrast to fully targeted searches where they are assumed to be phase-locked. In this work, we search for the CW counterparts emitted by 34 pulsars using data from the first and second parts of the fourth LIGO–Virgo–KAGRA observing run. …

Coherent Two-Photon Backscattering And Induced Angular Quantum Correlations In Multiple-Scattered Two-Photon States Of The Light, Nooshin M. Estakhri, Theodore B. Norris

Engineering Faculty Articles and Research

We present the emergence of coherent two-photon backscattering, a manifestation of weak localization, in multiple scattering of maximally entangled pure and fully mixed two-photon states and examine the effect of entanglement and classical correlations. Quantum correlations in backscattering are investigated for finite three-dimensional disordered structures in the weak localization regime, as well as systems of a small number of scatterers with specified spatial arrangements. No assumptions are made about the statistical behavior of the scattering matrix elements. Furthermore, we study the interplay between quantum correlations induced by multiple scattering and the correlations that may be present in the illumination fields, …

Examining Inmate Labor In Emergency Management: Contributions, Challenges, And Ethical Considerations, Boris Eugene Valiance

Walden Dissertations and Doctoral Studies

Incarcerated individuals remain inconsistently engaged in disaster preparedness, response, and recovery, creating both an operational gap and an ethical challenge regarding labor equity, safety, voluntariness, and human dignity. Guided by RBT and EMT, the purpose of this qualitative case study was to explore how incarcerated individuals are utilized in emergency management and to examine stakeholder perceptions of the operational, ethical, and policy implications of inmate labor programs. The research questions examined current utilization patterns, stakeholder-perceived benefits and drawbacks, and ethical concerns influencing participation decisions. Data were collected through semi structured interviews with purposefully sampled emergency management professionals, policymakers, and correctional …

The Impact Of Social Determinants Of Health On Alcoholism Among African American Communities Aged 65 And Older, Kymberly Williams

Walden Dissertations and Doctoral Studies

Alcohol use disorder among African American older adults (aged ≥65) remains an underrecognized contributor to preventable morbidity and diminished quality of life. Although previous research has identified individual risk factors for alcohol misuse, little is known about how social determinants of health shape alcohol use among this population. The purpose of this descriptive phenomenological study was to explore how family support, experiences of racial discrimination, religious engagement, and economic stability influence late-life alcohol use. Cultural Resilience Theory guided the exploration of how cultural resources and structural stressors influence alcohol use. Five African American adults aged 65 years and older were …

Racial Profiling In Traffic Enforcement: A Qualitative Exploration Of Police Chiefs' Perspectives On Traffic Stop Data Analysis, Peter J. Didomenica

Walden Dissertations and Doctoral Studies

Racial profiling of people of color by police departments as part of traffic enforcement practices is a pervasive practice in the United States. The practice is a form of systemic racism, the conceptual framework for this study, that has resulted in people and communities of color suffering its deleterious effects. Although statistical analysis of traffic stop data is most effective in uncovering racial profiling in traffic enforcement, most police departments fail to conduct such analysis, and for those departments that do so, there is no uniform judicially accepted method. The purpose of this study was to understand the reasons most …

Fecal Fatty Acids And Other Risk Factors Associated With Multiple Sclerosis Score, Progression And Diagnosis Among Hispanic Adults, Juliana Ayala-Viqueira

Walden Dissertations and Doctoral Studies

Multiple sclerosis (MS) is a chronic neurological condition with insufficient research regarding risk factors influencing MS severity score (MSSS), progression and diagnosis among Hispanic adults living in the United States. This cross-sectional study assessed factors associated with MS score, progression and diagnosis using secondary data from the International Multiple Sclerosis Microbiome Study (iMSMS). Guided by the ecological model, the study included N = 576 participants with MS. Manuscript 1 explored the association between body mass index (BMI), sodium consumption, and the MS severity score in a Hispanic adult population. A multiple linear regression was conducted to examine whether age and …

An Early Lexical Screening Tool For British English: Psychometric Properties And Clinical Utility, Allegra Cattani, Dora Bianchi, Caroline Floccia

School of Psychology

BackgroundExisting direct measures of vocabulary for ages 2–3 years are insufficient as vocabulary increases to include nouns, verbs, adjectives and adverbs, reflecting qualitative changes that support emerging grammatical abilities.AimsThe present study aims to establish the psychometric properties and validate a lexical screening tool for 19–36-month-old British English-speaking children, the WinG (Words in Game) test. Specifically, it examines gender differences in internal consistency, concurrent validity and predictive gender invariance across comprehension and production tasks. In addition, the study evaluates the diagnostic accuracy of the tool by establishing clinical cut-off scores to distinguish children with typical versus at-risk language development. Finally, it …

Tree Layer Composition And Regeneration Status Of Quercus Floribunda Lindl. On Different Aspects Of Nainital Catchment In Kumaun Himalaya, Ambica Agnihotri, Ashish Tewari, Shahbaz Ali

Journal of Environmental Science and Sustainable Development

Oaks are climax-forming species found at various elevations in the Himalayas between 2100– 2700 masl. However, aspect-wise regeneration patterns of Quercus floribunda in the Nainital catchment remain poorly documented. While previous studies focused on oak forest structure, the present study provides new insight into aspect-wise variation in the regeneration stages of Q. floribunda in relation to microclimatic conditions. The present study aims to evaluate tree composition and the regeneration status of Q. floribunda forests across different slope aspects in the Nainital catchment area of the Kumaun Himalaya. Four sites representing different slope aspects were selected in the Nainital catchment. Soil …

Usa V. Dennis Bastian

2026 Decisions

USDC for the Middle District of Pennsylvania

Nanoscale Morphological Perturbations Of Lipid Membranes Induced By Membrane Active Peptides, Yasith Sandeepa Indigahawela Gamage

USF Tampa Graduate Theses and Dissertations

Membrane-active peptides (MAPs) are a diverse group of biologically relevant molecules that induce nanoscale modulations during their interactions with cell membranes. Understanding the precise mechanism by which these MAPs perturb or modulate the cell membranes is a cornerstone of membrane biophysics, as it facilitates rational design of useful therapeutics. That is, if we have the knowledge to determine what the peptide can do, how selective it is, or how toxic it might be, we can optimize them and design new peptide therapeutics such as for antimicrobial, anticancer, or drug-delivery applications. In general, MAPs can be categorized into two classes based …

Extrafloral Nectaries In Woody Plants: Toward An Integrated Framework For Ant-Mediated Plant Defense, Fangming Liu, Qifei Cai, Victor Busov, Zhen Liu

Michigan Tech Publications

Extrafloral nectaries (EFNs)—secretory structures that recruit predatory arthropods as indirect defenders against herbivory—have been studied almost exclusively in herbaceous systems, leaving a critical gap in our understanding of plant defense in woody plants. In trees, secondary growth, ontogenetic regulation, and seasonal phenology generate structural and temporal heterogeneity in EFN expression poorly captured by existing frameworks. We synthesize evidence across structural, chemical, and functional dimensions of EFN biology to develop an integrated framework for perennial trees. Our analysis suggests that methodological limitations in EFN detection likely bias the current chemical record of woody EFNs, while incomplete chemical characterization constrains the evaluation …

Implementation Of A Follow-Up Call To Improve Glp-1 Medication Compliance, Hanna Weitzman-Flanigan

DNP and Student Works

Background: Obesity is a major driver of healthcare spending in the United States. GLP-1 receptor agonists are effective for weight management; however, high rates of early discontinuation reduce both clinical and economic value.

Methods: A pre–post quality improvement project implemented a nurse-led follow-up call at four weeks.

Results: Adherence improved significantly (p=0.009), weight decreased by 10 pounds (p=0.023), and estimated annual savings per patient were $6,472, contingent on sustained long-term adherence. Total estimated project savings were $80,141.

Conclusion: Nurse-led follow-up calls are a high-value intervention supporting economic sustainability.

Full Issue: Summer 2026

DePaul Magazine

In DePaul Magazine's summer 2026 issue, learn how DePaul is living its Vincentian mission through innovative community engagement and service learning, exemplified by its Irwin W. Steans Center and Speech Language Pathology and Occupational Therapy graduate programs. Also, meet alumna Kate Steinberg who revisits her youth and DePaul days as a rising social media influencer, get the latest news from DePaul's 10 colleges and schools, and much more.

Class Notes

DePaul Magazine

From promotions to performances, see the latest accomplishments by DePaul alumni across class years and generations. Plus, read alumni spotlight profiles of Derrick M. Robinson Jr. (SCPS '11), who battles bullying through sneakers donations, and Alessandra Swanson (JD '09), a first-generation alumna who rose to partner at a prominent national law firm.

Sensitivity Analysis Of A Line-Scan Hyperspectral Camera For Single-Channel Ifld-Based Solar Induced Fluorescence Retrieval And Early Nitrogen Stress Detection In Cotton, Angelin Regina Maria Villanueva Favorito

Electronic Theses and Dissertations Archive

Nitrogen (N) deficiency is a significant contributor to crop stress and yield loss in cotton, yet early detection remains challenging because conventional vegetation indices such as NDVI only resolve physiological changes after prolonged stress has produced outward structural symptoms. Solar-induced chlorophyll fluorescence (SIF), estimated via the improved Fraunhofer Line Depth (iFLD) method, offers a functional indicator of photosynthetic activity that responds to stress before structural changes emerge. This thesis presents two studies investigating the use of a single-channel line-scan hyperspectral camera for proximal SIF retrieval and its application to early N-stress detection in cotton. Study I demonstrated that an in-scene …

On Culpability: When Ai Goes Wrong, Who Is At Fault?, David J. Mulder

Faculty Work Comprehensive List

"I found the book so engrossing precisely because it forced me to sit in the discomfort of distributed blame, especially as someone who uses AI regularly."

Posting about ­­­­­­­­the novel Culpability from In All Things, an online hub that offers insight into maintaining and faithful and orthodox  Reformed Christian worldview while fearlessly engaging in  every aspect of contemporary life – until all is made new.

On Culpability

Al Kuwait Hospital Dubai, Emirates Health Services 1st Research Week 2025: Research Abstracts Of Clinical And Scientific Advances, Suad Hannawi, Linda Saf Eldin, Alaa Abuquta, Yusra Abdulrahman, Maryam Yaslam, Sabaa Saleh Al-Hemyari, Maimouneh Qazi, Noor Majed Al Mheiri, Ahmed Alamadi, Alia Aljasmi, Sondos Al Salmi, Maria Al-Salmi, Moza Aljamri, Ahmed Ibrahim Abdulrahman, Sharifa Alamadi, Haifa Hannawi

Saudi Medical Journal

No abstract provided.

Seasonal Variation Of Diabetic Ketoacidosis Among Children And Adolescents With Type 1 Diabetes: A Single-Center Tertiary Experience, Nour Gazzaz, Fajr A Saeedi

Saudi Medical Journal

Objectives: Diabetic ketoacidosis (DKA) seasonal variations among children and adolescents with type 1 diabetes mellitus (T1DM) have been widely studied; however, findings remain inconsistent. Although several studies reported a higher incidence during colder months, others showed no consistent patterns. This study investigated whether DKA frequency and severity vary across seasons, particularly in humid cities. Methods: This retrospective cohort analyzed children and adolescents with T1DM admitted to a tertiary hospital with DKA (2015–2025). Data included demographics, seasonal admission trends, clinical severity, and outcomes. Statistical analyses involved the Chi-square and ANOVA tests. Results: A total of 369 DKA cases …

Glp-1 Receptor Agonists And Sglt-2 Inhibitors In Diabetic Nephropathy: A Comparative Study, Sara Ghadeer Alghadeer, Sama Sami Kanfar, Zakiah Dheya Algallaf, Fatimah Mudhar Alfardan, Rana Alshammrany, Maha Farhat, Cyril Cyrus

Saudi Medical Journal

Objective: To investigate the effects of glucagon-like peptide-1 receptor agonist (GLP-1RAs) on renal function in type 2 diabetes mellitus (T2DM) patients and compared their efficacy to sodium-glucose co-transporter-2 inhibitors (SGLT-2i) in managing diabetic nephropathy. Methods: This is a retrospective cohort study conducted at King Fahad University Hospital, including 115 adults (≥ 18 years) with T2DM and baseline estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73m², treated with GLP-1RAs or SGLT-2i for over 1 year. Patients on renal replacement therapy, nephrotoxic drugs, or with incomplete records were excluded. Data were analyzed with Jeffrey's Amazing Statistics Program; the significant value …

Investigating Medical Radiation Awareness Of Saudi Arabian Cardiologists In Catheterization Labs: A Survey Study, Abdulmajeed Alotaibi, Raseel Alsallum, Reemas Alotaibi, Ali M. Aldhebaib, Noha Althubaity, Oinam Gokulchandra Singh, Zyad M. Almutlaq, Abdulaziz M. Albaraikan, Winnie Philip, Abrar M. Al-Mutairi, Mostafa Alqarras, Basma Alrowailli, Abdulrahman Alkhulaifi, Dhaifallah Ziyad Alanazi

Saudi Medical Journal

Objectives: To assess the knowledge, attitudes, and practices of interventional cardiologists in Kingdom of Saudi Arabia (KSA) regarding occupational radiation safety. Occupational radiation exposure poses significant long-term health risks for interventional cardiologists. Understanding current safety knowledge and practices is essential for guiding improvement strategies. Methods: A multicenter, cross-sectional survey was administered across several cardiac centers in KSA. The survey evaluated radiation safety awareness, use of dosimetry monitoring, and adherence to protective measures among practicing interventional cardiologists. Results: The study identified notable gaps in radiation safety knowledge and considerable inconsistencies in dosimetry monitoring. Despite these shortcomings, participants demonstrated high compliance …

Awareness Of The Mediterranean Diet And Its Perceived Effect On Cardiovascular Health In The Western Region, Saudi Arabia, Abdullah M. Alharbi, Mohammed S. Alsaedi, Mutaz S. Alharbi, Faisal F. Almutairi, Adeeb M. Aloufi, Azzam M. Alharbi, Rakan D. Alsaedi, Hatim F. Alhejaili, Motasem M. Alyamani

Saudi Medical Journal

Objective: To increase awareness of mediterranean diet (MD) and its perceived effects on cardiovascular health, enhance knowledge and inform public health efforts aimed at improving the population's health outcomes of. The MD comprises heart-healthy eating patterns high in vegetables, legumes, nuts and seeds, and fruits. Methods: This cross-sectional study involved adult participants who were living in the Western region of the Kingdom of Saudi Arabia. The data were collected online through social media platforms, then cleaned, coded, and analyzed using Statistical Package for the Social Sciences, version 21 to generate key insights. Results: A total of 390 participants were included …

Early Initiation And Dual Patterns Of Cigarette And E-Cigarette Use Among Adults In The Eastern Province, Saudi Arabia: A Cross-Sectional Study, Haidar A. Alridha, Nora A. Alafif

Saudi Medical Journal

Objectives: To explore the early initiation of cigarette and e-cigarette use and the dual patterns of usage among adults in the Eastern Province of Saudi Arabia. Methods: A cross-sectional survey was conducted from December 2024 to February 2025 among adults living in the Eastern Province. An online self-administered questionnaire collected data on sociodemographic characteristics, smoking behaviors, age of initiation, dual-use patterns, and quit attempts. Convenience sampling was applied, and a total of 551 participants were included. Descriptive statistics summarized distributions of smoking behavior and initiation age. Pearson's Chi-square tests were used to examine associations between smoking status, age of initiation, …