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Neurocognitive Outcomes And Functional Independence In Adult Survivors Of Childhood Medulloblastoma Diagnosed Over 3 Decades, Chiara Papini, Sedigheh Mirzaei, Mengqi Xing, Ingrid Tonning Olsson, Ralph Salloum, Katharine R Lange, Deokumar Srivastava, Wendy M Leisenring, Rebecca M Howell, Kevin C Oeffinger, Leslie L Robison, Gregory T Armstrong, Kevin R Krull, Tara M Brinkman

Faculty, Staff and Student Publications

Background: Treatment of childhood medulloblastoma has evolved to reduce neurotoxicity while improving survival. However, the impact of evolving therapies on late neurocognitive outcomes and adult functional independence remains unknown.

Methods: Adult survivors of childhood medulloblastoma (n = 505; median [minimum-maximum] age, 29 [18-46] years) and sibling controls (n = 727; 32 [18-58] years) from the Childhood Cancer Survivor Study completed surveys assessing neurocognitive problems and chronic health conditions (CHCs). Treatment exposures were categorized as historical (craniospinal irradiation [CSI] ≥ 30 Gy, no chemotherapy), standard-risk (CSI > 0 to < 30 Gy + chemotherapy) and high-risk (CSI ≥ 30 Gy + chemotherapy) therapy. Latent class analysis identified patterns of functional independence using employment, independent living, assistance with routine/personal care needs, driver's license, and marital/partner status. Multivariable models estimated the risk of neurocognitive impairment in survivors versus siblings and by treatment exposure group, and associations between neurocognitive impairment, CHCs, and functional independence.

Results: Survivors in each treatment exposure group had a 4- to 5-fold elevated …

Is Modulation Of Immune Checkpoints On Glioblastoma-Infiltrating Myeloid Cells A Viable Therapeutic Strategy?, Shashwat Tripathi, Jared T Ahrendsen, Michael A Curran, Crismita Dmello, Peng Zhang, Roger Stupp, Ganesh Rao, Amy B Heimberger

Faculty, Staff and Students Publications

The field of immunology has traditionally focused on immune checkpoint modulation of adaptive immune cells. However, many malignancies such as glioblastoma are mostly devoid of T cells and rather are enriched with immunosuppressive myeloid cells of the innate immune system. While some immune checkpoint targets are shared between adaptive and innate immunity, myeloid-specific checkpoints could also serve as potential therapeutics. To better understand the impact of immune checkpoint blockade on myeloid cells, we systematically summarize the current literature focusing on the direct immunological effects of PD-L1/PD-1, CD24/Siglec-10, collagen/LAIR-1, CX3CL1/CX3CR1, and CXCL10/CXCR3. By synthesizing the molecular mechanisms and the translational implications, …

Cover And Forewords, C. Nicholas Raphael

The Geographical Bulletin

Cover and Forewords

Volume 40-1 Complete Issue, C. Nicholas Raphael

The Geographical Bulletin

Volume 40-1 Complete Issue

Regions Of Risk: A Geographical Introduction To Disasters By Kenneth Hewitt, Taly D. Drezner

The Geographical Bulletin

Regions of Risk is a comprehensive text that painstakingly describes how disasters and the threat of disasters shape and geographically alter communities and regions all over the world. In his introduction, Hewitt writes, "Any given risk or disaster event is distinguished by its geographic location and setting. These are important keys to the origins of danger, the forms of damage and whom they most affect."

Exploring Geographic Information Systems By Nicholas Chrisman, Eric Matranga

The Geographical Bulletin

Rather than attempting to define the bounds and scope of geographic information, Chrisman provides an organizational framework that" . .. challenges the reader to participate in the exploration". Exploring Geographic Information Systems uses a nested set of interrelated issues to emphasize the need for users to think critically about the appropriate use of methods, tools, and data in GIS.

Physical Hydrology By S. Lawrence Ding-Man, Patricia J. Beyer

The Geographical Bulletin

As the public eye increasingly focuses on issues related to the use and quality of water, the science of hydrology expands from its position as an academic and engineering endeavor to one of prominance in people's everyday lives. With this expansion comes the need for education, not only for hydrologists and geomorphologists, but for biologists, botanists, earth scientists, climatologists, land managers, developers and policy makers. Water is a fascinating and complex substance: not only is water itself a resource, but it is also a main pathway for energy and chemical transfer in the Earth-atmosphere system.

Environmental Geography: Science, Land Use, And Earth Systems By William M.Marsh And John M. Grossa, Eric Matranga

The Geographical Bulletin

Environmental Geography is an introductory text for undergraduate instruction. Marsh and Grossa recognize a lack of geographic perspectives in such texts. They set as their task, building "on the traditional themes of geography". Concepts covered include environmental systems, principles of space, scale and distributions, and landscape as the result of human-environment interaction.

People, Politics, And Economic Life. An Interactive Exploration Of The Appalachian Region By Thomas Plaut, Wendy Shaw

The Geographical Bulletin

Appalachia, although often suffering from negative stereotypes, is in fact a region of great multidimensional diversity. In this diversity Appalachia is typical of much of America.

The Geography Of South Dakota. Edward By P. Hogan, Donald J. Berg

The Geographical Bulletin

Edward P. Hogan has done a considerable service for the people of South Dakota through writing The Geography of South Dakota, the first such volume in 78 years. It is a book that was long overdue, but such a project also needs the right person at the right place and the right time to author it.

Contemporary Europe: A Geographic Analysis. (7th Edition) By William H. Berent-Sen, Editor, Wendy Shaw

The Geographical Bulletin

Europe is a continent characterized by great complexity both physically and culturally. It is a fascinating place steeped in history yet seemingly in a state of con - stant flux. The region provides a challenge to authors who endeavor to present a comprehensive view of Europe. This book targets students in introductory col - lege courses and focuses on contemporary Europe. Each chapter has a different author, writing style, approach, and struc - ture that reflects that author's area of in - terest and expertise. Chapters are in - cluded that are topically focused such as those on population and …

The Geographic Society And Gamma Theta Upsilon At Arizona State University, Malcolm L. Comeaux

The Geographical Bulletin

Throughout most of the history of Arizona State University (founded in 1885) there has been a strong student organization devoted to the study of geography and the state of Arizona . This organization was established early, and once established, it always existed. A club such as this one is particularly important to students, since belonging to a small group leads to comraderie and lifelong friendships, and it can be a valuable learning experience. One of the main goals of the geography student organization was always the taking offield trips, and such field trips are fondly remembered by ex-members. Prof. Fred …

Projections And Perceptions Editorial Comment: The Limits Of Convergence; Nature, Nurture, And Growth, Jeffrey D. Sachs

The Geographical Bulletin

For the first time in history, almost all of the world's people are bound together in a global capitalist system. This momentous development forces us to think anew about the world economy. In the past, differences in policies across regions of the world resulted in vast differences in economic performance; in the future, policies are likely to be more similar. As a result, large parts of the developing world will narrow the income gap between themselves and richer nations. But this process of convergence, by itself, will go only so far. With or without markets, many developing countries will be …

Volume 40-2 Complete Issue, C. Nicholas Raphael

The Geographical Bulletin

Volume 40-2 Complete Issue

The Geography Of Kuwaiti Oil Transportation 1970-1980, Waleed Ai-Menais

The Geographical Bulletin

The transportation of oil from Kuwait between the years 1970- 80, which was a period of relative political stability, is discussed. Based on physical, geopolitical and economic factors the country elected to use tankers rather than pipelines as did many other Gulf countries. During the period 1970- 80 the oil field to transport facilities, onshore and offshore rapidly expanded and technologically improved. Paralleling this active growth, oil tanker construction and capacity had increased. In recent years geopolitical circumstances in Kuwait and emerging Asian markets justify the option of tankers moving oil via the Gulf over pipeline transport to Mediterranean ports.

Latino Migration To Green Bay, Wisconsin In The 1990s, Marcelo Cruz

The Geographical Bulletin

This paper explores Latino urban migration to Green Bay, Wisconsin, an intermediate size city of approximately 100,000 people. According to the census of 1990 there were approximately 1,500 Latinos living in Brown County with 1,000 ofthese living in the city of Green Bay. By 1997, estimates of the Latino population in Green Bay are from 6,000 to 7,000. Such a growth rate makes Latinos the fastest growing minority group in the city. The paper explores the nature of the migration process within the spatial and temporal context of Latino presence in the major urban centers of Wisconsin, and analyzes settlement …

Projections And Perceptions Editorial Comment: Has Land Use Development Lost Touch With The American Landscape? The Need For Geographers In Planning, William M. Marsh

The Geographical Bulletin

There is a predictable sameness creeping over the fact of the North American landscape. In the past several decades, highways, shopping centers, residential subdivisions and most other forms of development have taken on a remarkable similarity from coast to coast. Not only do they look alike, but modern developments also tend to function alike, including the way they relate to the environment; that is, in the way land is cleared and graded, streets are laid out, stormwater is drained, buildings are sited and designed, and landscaping is arranged. We know that this fa~ade of development masks an inherently diverse landscape …

А Review Of Scorpiofauna Of China: Nomenclatural Notes And Updated Faunistic Catalogue (Arachnida: Scorpiones), Victoria Tang

Euscorpius

Two genera associated with the Chinese scorpiofauna are reviewed, Razianus Farzanpay, 1987 and Reddyanus Vachon, 1972. Holotype female of Razianus xinjianganus Lourenço et al., 2010 is presumed to be lost, as well as all type material of other Chinese scorpions described before 2020. Comments are given on the species composition of genus Reddyanus with a new synonym: Isometrus (Reddyanus) tibetanus Lourenço & Zhu, 2008 = Reddyanus assamensis (Oates, 1888) syn. n. Reddyanus kanak Lourenço, 2023 is tentatively considered as a nomen dubium. An updated catalogue of Chinese scorpiofauna is provided, including their type locality and type depository, protonym, synonym(s), …

Feasibility Study For Providing Remedial Measures For Overburden Dump In New Majri Ug To Oc Mine, Wcl Majri Area, Warora, Chandrapur, Himanshu Kumar Jangir, Rahul Shende, Omkar Navagire, Srinivasan Venkatraman, Anirban Mandal, Anjan Patel

Journal of Sustainable Mining

The central region of India is abundant in fertile black cotton soil, and the presence of such weak floors in open-cast mines poses significant slope stability concerns for overburden (OB) dumps. Addressing these issues is crucial for ensuring safe mining operations and cost-effectiveness. Several coal mines in this region have experienced overburden dump collapses due to the weak soil foundation. To enhance slope stability and mitigate the heaving effect near the toe of the dump, this study proposes parametric research that explores the flattening of the overall slope angle of the dump, bench angle optimization, and various feasible dimensions for …

Enhancing Smartphone Authentication By Integrating Decision-Making Model With Touch Pressure, Finger Location Data, And Advanced Cybersecurity Techniques, Maytham M. Hamood, Moceheb Lazam Shuwandy, Rawan Adel Fawzi Alsharida

Iraqi Journal for Computer Science and Mathematics

Smartphone authentication methods face significant challenges in achieving high accuracy, robustness, and usability within cybersecurity applications. Traditional methods, such as passwords and biometric recognition, often lack adaptability and are prone to high false-positive rates, impacting security and user acceptance. This study presents a novel hybrid approach incorporating machine learning (ML) and the Analytic Hierarchy Process (AHP) in a framework to facilitate decision-making abilities and improve smartphone authentication. A novel dataset was constructed based on 3D touch sensor data (pressure levels and spatial dynamics) collected from 20 participants performing tasks per task over sessions, where AHP was used to rank/choose relevant …

Cross-Domain Transfer Learning For Domain Adaptation In Autism Spectrum Disorder Diagnosis, Kush Gupta, Amir Aly, Emmanuel Ifeachor

School of Engineering, Computing and Mathematics

A cross-domain transfer learning approach is introduced to address the challenges of diagnosing individuals with Autism Spectrum Disorder (ASD) using small-scale fMRI datasets. Vision Transformer (ViT) and TinyViT models pre-trained on the ImageNet, were employed to transfer knowledge from the natural image domain to the brain imaging domain. The models were fine-tuned on ABIDE and CMI-HBN, using a teacher student framework with knowledge distillation loss. Experimental results demonstrated that our method outperformed previous studies, ViT models, and CNN-based models. Our approach achieved competitive performance (F-1 score 78.72%) with a much smaller parameter size. This study highlights the effectiveness of cross-domain …

Pope Francis On Forced Migration: A Pastoral Of Mercy And Its Relevance In The Indonesian Context, Alexander Hendra Dwi Asmara, Martinus Dam Febrianto

Asia Pacific Mission Studies

Dealing with refugees, was the late Pope Francis’ legacy, during his pontificate, both as the leader of the Catholic Church and a global figure. This article reviews Francis’ pastoral approach of mercy, especially in his concern and advocacy for migrants and refugees, as expressed through his gestures, statements, thoughts, proposals, and policies. Along with issues of global inequality and ecological damage, Francis believed that forced migration can only be addressed through joint efforts based on recognizing human dignity, solidarity, the need for participation, as well as connectivity and inclusivity that encompasses the entire human family. This article then highlights the …

Migrants For The Sake Of The Lord, Fr. Renzo De Luca, Sj

Asia Pacific Mission Studies

This article presents the 37 Japanese Martyrs of Japan proposed for beatification who died in the 1868–71 period. They represent a little-known part of the so called “Last Persecution” of Japan. They are proposed as an example of exiled people who accepted the trials they suffered because of their Faith. First, a brief background of their situation is given, who they were, and the influence they had in Japanese society, which was mainly the introduction of religious freedom in Japan by the Meiji Government that opened a cultural and religious exchange with the West. Some examples are given of their …

Rethinking Immigration Enforcement, Peter L. Markowitz

Florida Law Review

As the nation turns the page away from the dark chapter of President Trump’s relentless assault on immigrants, it is time to take stock of the nation’s unprecedented immigration enforcement regime. During its relatively short existence, the Immigration and Customs Enforcement agency (ICE) has deported more than twice as many people as were deported in the entire previous history of the United States. The human and fiscal costs of ICE’s mass deportation agenda are astronomical, and there is almost universal agreement across the political spectrum that the United States’ immigration enforcement apparatus is badly broken. That, however, is where the …

Held At Gunpoint: Applying The Physical Restraint Sentencing Enhancement, Joshua Mccroskey

Florida Law Review

Federal circuit courts of appeal often disagree about how to interpret the United States Sentencing Guidelines. One contentious guideline is the physical restraint sentencing enhancement. This enhancement increases the sentence of a defendant who physically restrained a victim during a crime. Circuit courts disagree about whether to apply this enhancement to a defendant who points a gun at a victim and tells that victim not to move. Four circuit courts interpret the physical restraint enhancement narrowly and only apply it when a defendant does something highly similar to tying or locking up a victim. Three circuits interpret the enhancement very …

Acquiring Ethical Ai, David S. Rubenstein

Florida Law Review

Artificial intelligence (AI) is transforming how the federal government operates. Under the right conditions, AI systems can solve complex problems, reduce administrative burdens, improve human decisions, and optimize resources. Under the wrong conditions, AI systems can lead to widespread discrimination, invasions of privacy, and the erosion of democratic norms. A burgeoning literature has emerged to square algorithmic governance with the precepts of constitutional and administrative law. Federal procurement law, however, remains a dangerous blind spot in the reformist agenda. This Article pivots into that neglected space and emerges with comprehensive framework for acquiring ethical AI. Toward that end, the Article …

State-Created Environmental Dangers And Substantive Due Process, Shannon Roesler

Florida Law Review

This Article focuses on litigation arising out of contaminated drinking water in Flint, Michigan, lead paint in New York City public housing, and harms to young people from the impacts of climate change. At the heart of each case is a claim that state officials violated the plaintiffs’ substantive due process rights by creating or enhancing an environmental danger and then deliberately failing to mitigate the risk to the plaintiffs. Although the plaintiffs characterize their claims in similar fashion, the three cases are not likely to enjoy the same success as they move through the courts. The scholarly commentary thus …

Optimization Of The Cross-Section Of Generic Flexible Bridges, Manal Kamal Zaki, Mina M. Helmy, Mark M. Tawadros

Journal of Engineering Research

This paper investigates the behavior of flexible bridges prone to aerodynamic instabilities due to wind. Optimal cross-sections that reduce aerodynamic forces are recommended. This is achieved by studying a variety of bridge sections with different widths of upper and lower sloping edges in addition to studying the upper and lower cramps of the deck. The wind velocities are also parameterized. Computations are developed based on the powerful computational fluid dynamics (CFD) method known as FLUENT and embedded in ANSYS software. For parametric study, a design of experiments (DOE) is performed based on the response surface methodology (RSM) combined with the …

Anthropology Of Enabling People With Hearing Difficulties In Pub-Lic Entertainment Spaces: "A Case Study Of The Nile Corniche In Minia City", Amna Waz Amgad

Journal of Engineering Research

God compensates a person who suffers from a hearing defect by allowing that sense to give way to the part of his perception that it was expected to occupy, stimulating another sense, or by requiring him to interact with his society in other ways to compensate for the effects of his defect. As a result, the research problem was the need to develop open public entertainment spaces that are more welcoming to people who have hearing difficulties. Each individual can enjoy the space in accordance with his or her own needs, thereby implementing the Egyptian Constitution's principle of equality among …

Effects Of Processing Parameters On Kerf Cutting Quality Following Abrasive Waterjet Slotting Of Ti-6al-4v/Cfrp/Al7075 Stacks, Abeer Eisa, Abdulaziz Elshinawi, Mohamed Fattouh

Journal of Engineering Research

Abrasive water jet machining (AWJM) presents a viable substitute to traditional machining methods for cutting straight kerfs in Ti-6Al-4V/CFRP/Al7075 composite stacks. This study investigated the influences of various process settings, namely the hydraulic pressure (P), traverse speed (V), and stand-off distance (SOD) on kerf characteristics, including the kerf geometry (W_k), taper angle (θ_K), roughness (R_a), and the material removal (MRR). The metal plates, including Ti-6Al-4V and Al7075, exhibited a positive taper angle, whereas the CFRP composite plate revealed a negative taper angle across …