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N-Glycosylation In The Serpin Domain Of The C1-Esterase Inhibitor In Hereditary Angioedema, Zhen Ren, John Bao, Shuangxia Zhao, Nicola Pozzi, H. James Wedner, John P. Atkinson

2020-Current year OA Pubs

Hereditary angioedema is an autosomal dominant disorder caused by defects in C1-esterase inhibitor (C1-INH), resulting in poorly controlled activation of the kallikrein-kinin system and bradykinin overproduction. C1-INH is a heavily glycosylated protein in the serine protease inhibitor (SERPIN) family, yet the role of these glycosylation sites remains unclear. To elucidate the functional impact of N-glycosylation in the SERPIN domain of C1-INH, we engineered 4 sets consisting of 26 variants at or near the N-linked sequon (NXS/T). Among these, 6 are reported in patients with hereditary angioedema and 5 are known C1-INH variants without accessible clinical histories. We systematically evaluated their …

Phase I Study Of Bms-986299, An Nlrp3 Agonist, As Monotherapy And In Combination With Nivolumab And Ipilimumab In Patients With Advanced Solid Tumors, Blessie E Nelson, Shaun O'Brien, Rahul A Sheth, David S Hong, Aung Naing, Amy Xu, Rasika Suryawanshi, Derrick Mckinley, Ruslan D Novosiadly, Sarina A Piha-Paul

Faculty, Staff and Student Publications

Purpose: BMS-986299 is a first-in-class, NOD-, LRR-, and pyrin-domain containing-3 (NLRP3) inflammasome agonist enhancing adaptive immune and T-cell memory responses.

Materials and methods: This was a phase-I (NCT03444753) study that assessed the safety and tolerability of intra-tumoral BMS-986299 monotherapy (part 1A) and in combination (part 1B) with nivolumab, and ipilimumab in advanced solid tumors. Reported here are single-center results.

Results: 36 patients were enrolled, with breast (31%), colorectal (17%), and head and neck (14%) being the more commonly enrolled cancers. Most patients (58%) had received prior immunotherapy. Therapy was well-tolerated, with G1-G2 fever (70%), neutrophilia (36%), and leukocytosis …

Empirically Validating A Computational Model Of Automatic Behavior Shaping, Vincent Berardi, Tian Lan, Ariane Guirguis, Uri Maoz

Psychology Faculty Articles and Research

Background

Mobile sensing technology allows automated behavior shaping routines to be incorporated into health behavior interventions and other settings. In previous work, a computational model was built to investigate how to best arrange automatic behavior shaping procedures, but the degree to which this model reflects actual human behavior is not known.

Purpose

To translate a previously developed computational model of automatic behavior shaping into an experimental setting.

Methods

Participants (n = 54) operated a computer mouse and attempted to locate a hidden, randomly-placed target circle on a blank computer screen and clicks within some threshold distance of the target …

Perceived Anxiety Symptoms Of Board-Certified Behavior Analysts Who Work With The Autism Population, Elyra Gonzalez

Walden Dissertations and Doctoral Studies

The increase in autism spectrum disorder (ASD) diagnoses has led to a rise in mental health issues among board-certified behavior analysts (BCBAs). Burnout has been identified as the primary cause of emotional exhaustion, poor work-life balance, and stress. Despite this, direct interviews with BCBAs are limited. Previous research has indicated that BCBAs face high demands in their work; however, their mental health has not been thoroughly evaluated. Cognitive appraisal theory was used to demonstrate that the perceived symptoms are associated with anxiety, not just burnout. Semi-structured interviews with 10 BCBAs were conducted to gain direct feedback on their view of …

Perceived Anxiety Symptoms Of Board-Certified Behavior Analysts Who Work With The Autism Population, Elyra Gonzalez

Walden Dissertations and Doctoral Studies

The increase in autism spectrum disorder (ASD) diagnoses has led to a rise in mental health issues among board-certified behavior analysts (BCBAs). Burnout has been identified as the primary cause of emotional exhaustion, poor work-life balance, and stress. Despite this, direct interviews with BCBAs are limited. Previous research has indicated that BCBAs face high demands in their work; however, their mental health has not been thoroughly evaluated. Cognitive appraisal theory was used to demonstrate that the perceived symptoms are associated with anxiety, not just burnout. Semi-structured interviews with 10 BCBAs were conducted to gain direct feedback on their view of …

Investigating The Perceived Efficacy Of Support Groups As A Secondary-Organization Stress Intervention Measure For Hospice Nurses, Sade A. Allen

Doctoral Dissertations and Projects

This dissertation investigated the perceived efficacy of support groups as a secondary organizational intervention measure for hospice nurses. Workplace stress is a common issue in hospice care that impacts workers negatively. It results in declining mental, physical, and social wellness. While research indicates significant benefits of support groups, they are not commonly applied in hospice care. Support groups have been widely used in mental health for years to share information and experiences and discuss problems. This dissertation interviewed eight participants using a qualitative case study approach. The participants were recruited from an online hospice nurse group on Facebook. The information …

Workplace Conflict: Its Nature, Peculiarities, And Prevention, Ayo Ogunmolasuyi

Doctoral Dissertations and Projects

Workplace conflict can arise from negative attitudes, lazy coworkers, and stress. In most cases, conflict can be instigated by managers, supervisors, colleagues, or the employer's inability to meet specific demands or provide necessary resources. The aftermath of workplace conflict can be detrimental, destructive, and expensive when it escalates. Conflict can be a significant source of stress at work. The purpose of this phenomenological study was to explore the lived experiences of participants in regard to the nature of conflict, motivational tools, and strategies for conflict prevention. This study was directed by theoretical frameworks, including post-positivism, dual concern theory, social cognitive …

Understanding The Impact Of Covid-19 On The Mental Health Of Children And Parents During The Pandemic, Whitney S. Gray

Doctoral Dissertations and Projects

The COVID-19 pandemic presented parents with stressors that affected their well-being and their life satisfaction. The pandemic caused parents to struggle with balancing their families’ needs and maintaining their happiness. Prior to the pandemic, children and adolescents had a routine that accommodated their daily functioning and provided them with social contact. The pandemic added stress with parents working odd hours at work, having to adjust to their child’s school schedules, and not being able to contribute to their support system. In addition to these daily stressors, parents had to consider the precautions surrounding COVID-19 and the worries attached to the …

Doctor Of Ministry Final Portfolio: Addressing The Lack Of Christian Education In The Local Church Through Podcasting, Workshops, Flowcharts, And Advertisement For Ministry Launch, Tracy (Trey) Harris

Doctoral Dissertations and Projects

Why Theology? The "Why Theology" question will be defended to highlight the truths of systematic theology. The truths of systematic theology within the biblical text are rooted in the doctrines of biblical truths. Answering the why question of theology within Christian education from a systematic theological perspective empowers the local church with doctrinal truths about God's nature, character, and identity. Introducing Christian education to the local ministry offers next-level learning opportunities and a learning center for theological education. Theological education may not solve the entire ministry problem of the local church, but theological education will answer the why and enhance …

Arguments For The Sovereignty Of God In The Book Of Job, Elizabeth J. Welch

Doctoral Dissertations and Projects

The book of Job is a complex piece of wisdom literature studied for centuries using various methodologies to elucidate theological doctrines, biblical themes, and literary motifs. This dissertation aims to demonstrate that a midrashic form of exposition significantly expands the understanding of the Joban arguments for and against the sovereignty of God within the context of the ancient views of divine retribution and human suffering. Encapsulated in the legal motif, the disclosure and discussion of these views with associated themes, such as theocracy, theodicy, justice, and theophany, identified God’s sovereignty as the most prevalent doctrine in the book. The three …

A Phenomenological Study Exploring The Lived Experiences Of Former Adult Drug Users’ Sobriety Journey After Graduating From A Faith-Based/Spiritual Drug And Alcohol Recovery Program, Laurine Voltaire

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to investigate the lived experiences of former adult drug users and their sobriety journeys after graduating from a variety of faith-based or spiritual drug and alcohol recovery programs. The research included a systematic review and narrative synthesis of existing literature on faith-based and spiritual recovery programs to address the gap concerning the lived experiences of former users and an evaluation of the strategies and techniques vital for facilitating recovery. The guiding theoretical framework CHIME-D delineated the essential definitive characteristics such as connectedness, hope, identity, meaning of life, empowerment, and overcoming difficulties that …

Products Of Their Inheritance And Experiences: The Political And Personal Influences On John Quincy And Louisa Catherine Adams, Claude Randall Brawner

Doctoral Dissertations and Projects

John Quincy and Louisa Catherine Adams were important contributors to the American political landscape during a period of maturity. The Unites States was striving to solidify its independence within the dynamics of the global environment. The French Revolution and the resulting contingencies within the European nations had significant effect upon America. John Quincy and Louisa Catherine overcame significant ideological differences and each cooperated to provide essential differences within the global construct. Louisa Catherine began her marriage to John Quincy through an unexpected situation that was significantly expected and different from her childhood. The financial collapse of her father had significant …

Direction Of Prayer And Marital Satisfaction, Jeffrey Deyel Brothers

Doctoral Dissertations and Projects

The purpose of this correlational study was to assess the relationship between the constructs of prayer and marriage. Specifically, this study sought to answer the question of whether or not the direction of prayer, inward, outward, and upward was significantly correlated with marital satisfaction. Two hundred and one participants who were married, at least eighteen years of age, and who identified as Christian participated in the study. They completed a demographic questionnaire, the Prayer Thought Scale (PTS), and the ENRICH Couple Satisfaction Scale (CSS) online. Results indicated that there was no significant correlation between direction of prayer and marital satisfaction. …

The Masculine Perspective Of The Stigmatization Of Childlessness In Marriage In YorùBáLand: An Ile-Ife Phenomenological Study, Godwin Segun-George Olugbami

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe men's experiences with the stigmatization of childlessness in the context of marriage in Ile-Ife, Nigeria. The experience of childlessness as a universal phenomenon has been predominantly studied from the female perspective, and men are primarily neglected. The heteronormative ideal of women as 'mother/nurturer' is supported by only collecting women's fertility data in contrast to relatively suboptimal statistics in men's studies. This dissertation explores the view of ten African men set in the Yorùbá culture suffering from childlessness and its attendant stigmatization, mainly as a result of infertility. It provides in-depth interviews …

Analyzing Organizational Commitment And Organizational Citizenship Behavior In Telecommuting Work Environments, Joshua L. Hays

Doctoral Dissertations and Projects

The COVID-19 pandemic forced employees and organizations into telecommuting roles which created undesirable consequences for the employee (distractions, overworking, isolation, etc.) and the organization (emotional disengagement, turnover, control, lack of collaboration, etc.). The research design for this study was a quasi-experimental correlational design to analyze the relationship between organizational commitment and telecommuting environments. The data obtained from the participants was collected by using Google Forms survey design. Upon receiving the required (n = 100) completed surveys, the data was then inputted into the Statistical Package for Social Sciences (SPSS) version 29 for analysis. The participants of this study were from …

Investigating The Correlation Between Racially Based Trauma And The Imposter Phenomenon In High-Achieving Black Women, Tarra Lynn Winfield Ray

Doctoral Dissertations and Projects

This study investigates the imposter phenomenon, racially based trauma, and how the two correlate among high-achieving Black women. High achieving for this writing refers to Black women who attend college or graduate school, those in professional positions that require a degree, advanced degree, or professional licensure (i.e., corporate executives, medical doctors, attorneys, mental health clinicians, etc.), and entrepreneurs. Many current studies have focused on the unique and complex experiences that high-achieving Black women face while working to achieve goals and gain success. Many of these women have experienced racially based trauma, and many endorse the simultaneous experiencing of the imposter …

Care Providers Caring For Military Members Struggling With Grief, Clara Altagracia García

Doctoral Dissertations and Projects

This research aims to address the lack of grief support services for service members (SMs) and veterans, which affects them and the wider community. The mission is to uncover the needs of SMs and veterans and devise effective strategies to support them. The literature review will provide the foundation for the need for research and create a reasonable solution for a healthier grieving process for SMs. This research aims to determine how complicated grief goes undetected and how counseling can help SMs and veterans. The thesis project will impact the grief counseling process of others in this field and bring …

Caring For Ukrainian Healthcare Professionals In Wartime: Moral Injury And Psycho-Spiritual Intervention, Rodger L. Stenger

Doctoral Dissertations and Projects

This mixed-methods study examined the prevalence of Moral Injury (MI) among Ukrainian healthcare professionals (UHCPs) and their willingness to engage in evidence-based, psycho-spiritual interventions targeting MI that has resulted from the Russian invasion and the COVID-19 pandemic. MI is a psychological construct resulting from actions that violate an individual’s moral code and can overlap with Post Traumatic Stress Disorder (PTSD) symptoms. While MI has been extensively researched in the military, it has gained attention in healthcare settings. Utilizing the Moral Injury Symptom Scale-Healthcare Professional (MISS-HP), this study quantitatively identified a moderate prevalence of MI among doctors and nurses in Ukraine. …

Intimate Partner Violence And The Black Church Culture: A Place Of Judgement Or Healing, Indea J. Hamlin

Doctoral Dissertations and Projects

This transcendental phenomenological study will discover how Black clergy and lay leaders in urban communities respond to Black women who report intimate partner violence. Semi- structured interviews will take place in urban churches or secure locations within the communities. Six male and six female church pastors, clergy, and lay leaders will be selected as participants for the study, which will capture their firsthand experiences, levels of awareness and belief about the prevalence of IPV in urban communities, and their preparedness to address this form of violence against Black women. Thematic analysis will be employed to generate codes, uncover any themes …

An Examination Of Maternal Messages Given To Academically Successful African American Undergraduate Males By Their Single Mothers, Denee' Scott-Elliott

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to examine the lived experiences of successful African American undergraduate males from single-parent homes, and the maternal messages that contributed to their academic success and resilience. Research shows that African American males face an icreased risk of academic underachievement, particularly those raised by single mothers. The participants consisted of African American undergraduate males who grew up in a single-parent home headed by their mother. For the purpose of this study, academically successful males were defined as males enrolled in a Historically Black College or University (HBCU) in the District of Columbia, Maryland and …

Exploring Joint Manifestations In Rasopathies: A Prospective Survey, Lavinia Dobrea

Doctoral Dissertations and Projects

RASopathies, a group of genetic diseases, affects approximately 1 in 1000 people worldwide. Despite advances documented in medical journals, there is limited understanding about the impact of various joint problems on activities of daily living (ADL) and quality of life (QOL) among those afflicted. This study was conducted, utilizing a qualitative phenomenological methodology, to better understand the lived experiences of people with RASopathies impacted by joint problems. Participants were selected from RASopathy communities by employing purposeful sampling to ensure population representation. Data was obtained through online surveys and virtual interviews. Thematic analysis was used to identify recurring themes, and data …

Technology-As-Instrument: A Case Study Of Undergraduate Student Experience With Daw Technology, Brian Coski

Doctoral Dissertations and Projects

Within the typical music appreciation class, diverse subsections of students exhibit varying levels of experience that can result in challenging inequities in engagement and comprehension. For those students with no background in playing an instrument or singing, musical ideas often need more context and perspective. Technology can present an opportunity for all students to explore the elements of music by utilizing music production software as a virtual instrument. In this study, the researcher utilized curriculum strategies specifically designed to foster deep musical connection through a technology-as-instrument approach. Through informal learning and the tools of music production, students visualized and interacted …

Religiosity And Dating Relationships: How Individual And Dyadic Religiosity Influence The Dating Relationship Quality Among Indonesian Dating Couples, Hans Ega Saputra

Doctoral Dissertations and Projects

The study is a replication of the previous study conducted by Aragoni et al. (2021) to follow up on the future direction of the study by replicating the study within a new population of Indonesia. Research on how religiosity influences marital quality has been widely addressed, but little research has been conducted on the population of dating couples. Collectivism and religiosity are strongly embedded within the culture of Indonesia, which influence how Indonesian people view interpersonal relationships. Thus, the present study is critical because it addresses how much religiosity influences dating relationship quality among Indonesian dating couples. Religiosity as an …

Timeless: A Sanctuary In Libraries, Taylor D. Vaughan

Masters Theses

This Master of Fine Arts Creative Writing thesis focuses on the literary element: character development. It includes a vision and background for the thesis project as a whole. An analysis of characters involved in wartime conflict will focus on William Shakespeare’s tragedies Macbeth and Hamlet and various characters in C.S. Lewis’s Chronicles of Narnia. The creative manuscript that concludes the thesis incorporates fantasy and war genres and character development research. The manuscript aims to shed light on traumatic events in our modern world rather than use escapism in fantasy to ignore them.

Young Adult Fiction Through The Years: An Analysis Of What Readers Want, Treanna Greenwood

Masters Theses

In this literary critique, I discuss the advantages of reading young adult fiction, specifically fantasy. I define what young adult fantasy is, and then analyze some of the most famous young adult book series and discuss how popular they are and how they contribute to the genre. I also discuss works that are relevant to the creative piece I am submitting and explain why my piece has a place in the world of young adult fantasy. Finally, I acknowledge what I hope to contribute to the field.

Preformulation Study Of Kigelia Africana Fruit Ethanolic Extract As Topical Preparations, Tareq Maqlam, Abdullah H Maad, Mohammed E Shayoub, Zuheir Osman

Al-Ameed Journal for Medical Research and Health Sciences

Background: Preformulation studies have a significant role in anticipating formulation problems and identifying logical paths in dosage form technology.

Aim: This study aimed to evaluate the preformulation criteria of the aquatic ethanol extract of Kigelia africana fruit as topical antibacterial therapy.

Methods: The preformulation parameters of the extract were evaluated by testing its organoleptic characteristics, melting point, pH, spectroscopic assay, stability, solubility, and partition coefficient.

Results: The study demonstrated that the extract possessed satisfactory organoleptic properties, a melting point of 195.3–198.0 °C, a pH of 6.26, chemical stability under acidic conditions, photostability, higher solubility in basic conditions and in the …

The Frequency Of Elliptic Curves Over $\Mathbb{Q}[I]$ With Fixed Torsion, Alan S. Zhao

Rose-Hulman Undergraduate Mathematics Journal

Mazur\textsc{\char13}s Theorem states that there are precisely 15 possibilities for the torsion subgroup of an elliptic curve defined over the rational numbers. It was previously shown by Harron and Snowden that the number of isomorphism classes of elliptic curves of height up to $X$ that have a specific torsion subgroup $G$ is on the order of $X^{1/{d(G)}}$, for some positive $d(G)$ depending on $G$. We compute $d(G)$ for these groups over $\Qi$. Furthermore, in a collection of recent papers it was proven that there are 9 more possibilities for the torsion subgroup in the base field $\Qi$. We compute the …

The Likelihood Of Sport Fans Selecting A Team To Follow Based On Uniform Color, Frederick G. Grieve, Daniel L. Wann, Logan M. Grieve, Jordan M. Pearsall

Findings in Sport, Hospitality, Entertainment, and Event Management

The purpose of the present investigation was to examine the relationship between color and supporting sport teams. Some reasons why individuals support teams are team identification, need to belong, and the minimal group paradigm. Participants in this study (final sample N = 131) completed a questionnaire packet to assess their selection of teams because of uniform color. Participants provided their favorite team and demographics, then completed the SSIS, SFQ, vignette, and TAS. Results from the current study indicated that some participants selected a team based on color. Those who did select a team based on color reported that they would …

The State Of Ong Scholarship - A Symposium At Gonzaga University, Sara Van Den Berg, Thomas D. Zlatic, Paul A. Soukup, James Jarc, Kristina J. Morehouse, Heather M. Crandall, Dung Q. Tran, Kateland Wolfe

Communication Research Trends

No abstract provided.

Serving With The Strength God Supplies, Sarah Moss

The Voice

No abstract provided.