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Blast Tube Design: How Shape And Size Influence The Resultant Shock Wave, R. L. Bauer, C. E. Johnson Feb 2025

Blast Tube Design: How Shape And Size Influence The Resultant Shock Wave, R. L. Bauer, C. E. Johnson

Mining Engineering Faculty Research & Creative Works

Shock tubes and tunnels are often used in research settings as a way of producing high pressure shock waves in a smaller footprint or without the use of explosives. However, there is no standard geometric design across laboratories. Peak pressure is a significant parameter for characterizing a shock wave. However, different tube configurations could also affect parameters such as impulse and duration, yet no research has investigated how the scale of the tube affects the overall waveform shape. To understand the implications of shock tube design, tubes with a constant length to diameter ratio were evaluated to determine how tube …


Controlling Structural Phases Of Sn Through Lattice Engineering, Chandima Kasun Edirisinghe, Anjali Rathore, Taegeon Lee, Daekwon Lee, An Hsi Chen, Garrett Baucom, Eitan Hershkovitz, Anuradha Wijesinghe, Pradip Adhikari, Sinchul Yeom, Hong Seok Lee, Hyung Kook Choi, Hyunsoo Kim, Mina Yoon Feb 2025

Controlling Structural Phases Of Sn Through Lattice Engineering, Chandima Kasun Edirisinghe, Anjali Rathore, Taegeon Lee, Daekwon Lee, An Hsi Chen, Garrett Baucom, Eitan Hershkovitz, Anuradha Wijesinghe, Pradip Adhikari, Sinchul Yeom, Hong Seok Lee, Hyung Kook Choi, Hyunsoo Kim, Mina Yoon

Physics Faculty Research & Creative Works

Topology and superconductivity, two distinct phenomena, offer unique insight into quantum properties and their applications in quantum technologies, spintronics, and sustainable energy technologies. Tin (Sn) plays a pivotal role here as an element because of its two structural phases, α-Sn exhibiting topological characteristics and β-Sn showing superconductivity. Here, we demonstrate precise control of these phases in Sn thin films using molecular beam epitaxy with systematically varied lattice parameters of the buffer layer. The Sn films exhibit either β-Sn or α-Sn phases as the buffer layer's lattice constant varies from 6.10Å to 6.48Å, spanning the range from GaSb (like InAs) to …


Helicity Modulus And Chiral Symmetry Breaking For Boundary Conditions With Finite Twist, Gaurav Khairnar, Thomas Vojta Feb 2025

Helicity Modulus And Chiral Symmetry Breaking For Boundary Conditions With Finite Twist, Gaurav Khairnar, Thomas Vojta

Physics Faculty Research & Creative Works

We study the response of a two-dimensional classical XY model to a finite (noninfinitesimal) twist of the boundary conditions. We use Monte Carlo simulations to evaluate the free energy difference between periodic and twisted-periodic boundary conditions and find deviations from the expected quadratic dependence on the twist angle. Consequently, the helicity modulus (spin stiffness) shows a nontrivial dependence on the twist angle. We show that the deviation from the expected behavior arises because of the mixing of states with opposite chirality which leads to an additional entropy contribution in the quasi-long-range ordered phase. We give an improved prescription for the …


A Model For Advocacy: Advancing Policy Change In Support For Patients With Medicaid, Betsy J. Becker, Jenae Pope Feb 2025

A Model For Advocacy: Advancing Policy Change In Support For Patients With Medicaid, Betsy J. Becker, Jenae Pope

Posters and Presentations: Physical Therapy

There are differences in access and utilization of care for patients with Medicaid. When patients cannot access timely therapeutic care, the resulting outcomes are often poor. Because a major limiting factor in accessing services is insurance type, investigating optimal coverage practices is an important first step in advocating for change. This abstract reports on Phase One of a larger collaboration with state professional associations for physical therapy (PT), occupational therapy (OT), and speech-language pathology (SLP) to present a model that describes Medicaid authorization services for PT, OT, and SLP, serving as a guide for policy change.

We collaborated with the …


Dubai’S Future Mobility: Systems Thinking & Scenarios, Mohammed Mazloum Hanafy Feb 2025

Dubai’S Future Mobility: Systems Thinking & Scenarios, Mohammed Mazloum Hanafy

Theses

Transportation is one of the essential pillars of any smart city. The future of transportation in Dubai faces enormous hurdles in urban mobility, including a growing population density, congestion, and environmental issues. Without careful planning and policy actions, these problems would certainly worsen in the future. Thus, the purpose of this thesis is to investigate the future of urban mobility in Dubai and to suggest solutions for constructing a sustainable, efficient, and equitable transportation system by employing future foresight tools. Dubai has emerged in recent years as a global center for technological innovation, altering its built environment and reevaluating its …


Characterizing Phosphorus Removal And Recovery Performance Of A 3d Printed Iron-Embedded Polylactic Acid Composite, Colin B. Wilson, Anthony J. Parolari, Andrew Hiestand, Brooke K. Mayer, Allison Murray Feb 2025

Characterizing Phosphorus Removal And Recovery Performance Of A 3d Printed Iron-Embedded Polylactic Acid Composite, Colin B. Wilson, Anthony J. Parolari, Andrew Hiestand, Brooke K. Mayer, Allison Murray

Civil and Environmental Engineering Faculty Research and Publications

Green infrastructure (GI) has been heralded as a solution for reducing phosphorus (P) pollution through increasing stormwater runoff infiltration and improving water quality. Despite its global implementation, GI struggles to improve the effluent water quality discharged from these systems consistently. This research evaluates the P removal performance and recovery potential of iron-embedded polylactic acid (PLA) composites through a novel application of three-dimensional (3D) printed representative unit cells (RUC) that could be used to improve effluent quality in GI. The RUC required chemical oxidation to convert the embedded iron to hematite (Fe2⁢O3) to facilitate P adsorption. Batch …


Sovereignty, Sins, And The Reassertion Of Primary Taxing Rights By The United States, Michael J. Graetz Feb 2025

Sovereignty, Sins, And The Reassertion Of Primary Taxing Rights By The United States, Michael J. Graetz

Faculty Scholarship

In this report, Graetz argues that the United States must reassert its primary taxing rights over income long conceded to other countries, especially income from intellectual property created in the United States, and he explains some changes necessary to make that happen.


Childhood Sexual Trauma, Substance Use, And Antiretroviral Therapy Adherence Among Older Adults Living With Hiv: A Mediational Analysis, Monique J. Brown, Josie Zhang, Prince Nii Ossah Addo, Amandeep Kaur, Daniel Amoatika, Elizabeth L. Crouch Ph.D., Steven A. Cohen Feb 2025

Childhood Sexual Trauma, Substance Use, And Antiretroviral Therapy Adherence Among Older Adults Living With Hiv: A Mediational Analysis, Monique J. Brown, Josie Zhang, Prince Nii Ossah Addo, Amandeep Kaur, Daniel Amoatika, Elizabeth L. Crouch Ph.D., Steven A. Cohen

Faculty Publications

Childhood sexual abuse (CSA) is linked to substance use and lower antiretroviral therapy (ART) adherence. However, studies examining the mediational role of substance use between CSA and ART adherence are lacking. Therefore, the aim of this study was to determine the potential mediational role of substance use between CSA and ART adherence among older adults living with HIV (OALH) (n = 91). Mediation analyses assessed the direct and indirect relationships between CSA, substance use, and ART adherence. Statistically significant differences existed in substance use by gender (male vs. female: 12.3 vs. 9.97) and ART adherence by race (Black vs. …


Critical Picture Book Literacy, Caitlin Stewart, Heather Koopmans Feb 2025

Critical Picture Book Literacy, Caitlin Stewart, Heather Koopmans

Faculty and Staff Publications – Milner Library

This study sought to revisit established definitions of critical visual literacy and determine how this concept could be re-envisioned specifically for picture books when informed by the approaches of teacher education students who had received limited prior formal instruction on critiquing visual texts. Seventeen sophomore elementary education students engaged in written self-discourse around the visual narrative of Milo Imagines the World written by Matt de la Peña and illustrated by Christian Robinson where they generated questions and answers critically engaging with the visuals. These participants’ responses underwent thematic analysis informed by grounded theory which uncovered a collective definition for critical …


A Personalized Periodontitis Risk Based On Nonimage Electronic Dental Records By Machine Learning, Laura Swinckels, Ander De Keijzer, Bruno G. Loos, Reuben Joseph Applegate, Krishna Kumar Kookal, Elsbeth Kalenderian, Harmen Bijwaard, Josef Bruers Feb 2025

A Personalized Periodontitis Risk Based On Nonimage Electronic Dental Records By Machine Learning, Laura Swinckels, Ander De Keijzer, Bruno G. Loos, Reuben Joseph Applegate, Krishna Kumar Kookal, Elsbeth Kalenderian, Harmen Bijwaard, Josef Bruers

School of Dentistry Faculty Research and Publications

Objective: This study aimed to develop a machine-learning (ML) model to predict the risk for Periodontal Disease (PD) based on nonimage electronic dental records (EDRs).

Methods: By using EDRs collected in the BigMouth repository, dental patients from the US were included. Patients were labeled as cases or controls, based on PD diagnosis, treatment and pocketing. By learning from their data, a model was trained. The ability of the developed model to predict PD was evaluated by the accuracy, sensitivity, specificity and area under the curve (AUROC) and the most important features were determined. The best-performing model was applied …


Efficacy Of 3d-Printed Chitosan-Cerium Oxide Dressings Coated With Vancomycin-Loaded Alginate For Chronic Wounds Management, Sharareh Shahroudi, Amir Parvinnasab, Erfan Salahinejad, Shaghayegh Abdi, Sarah Rajabi, Lobat Tayebi Feb 2025

Efficacy Of 3d-Printed Chitosan-Cerium Oxide Dressings Coated With Vancomycin-Loaded Alginate For Chronic Wounds Management, Sharareh Shahroudi, Amir Parvinnasab, Erfan Salahinejad, Shaghayegh Abdi, Sarah Rajabi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Multifunctional wound dressings with antibacterial and antioxidant properties hold significant promise for treating chronic wounds; however, achieving a balance of these characteristics while maintaining biocompatibility is challenging. To enhance this balance, this study focuses on the design and development of 3D-printed chitosan-matrix composite scaffolds, which are incorporated with varying amounts of cerium oxide nanoparticles (0, 1, 3, 5, and 7 wt%) and subsequently coated with a vancomycin-loaded alginate layer. The structure, antibiotic drug delivery kinetics, biodegradation, swelling, biocompatibility, antibacterial, antioxidant, and cell migration behaviors of the fabricated dressings were evaluated in-vitro. The findings reveal that all of the formulations …


Iowa Waste Reduction Center Newsletter, February 2025, University Of Northern Iowa. Iowa Waste Reduction Center. Feb 2025

Iowa Waste Reduction Center Newsletter, February 2025, University Of Northern Iowa. Iowa Waste Reduction Center.

Iowa Waste Reduction Center Newsletter

Contents:

--- Diane Albertson Memorial Scholarship
--- Introducing new IWRC Advisory Committee Members
--- Launching Compost Training Program in Rural Midwestern Communities
--- 2024 MSEI Reminder
--- Resilient Iowa Communities
--- Industry news


Five-Year Outcomes Of Lenadogene Nolparvovec Gene Therapy In Leber Hereditary Optic Neuropathy, Patrick Yu-Wai-Man, Nancy Newman, Valérie Biousse, Valerio Carelli, Mark Moster, Catherine Vignal-Clermont, Thomas Klopstock, Alfredo Sadun, Robert C Sergott, Rabih Hage, Simona Degli Esposti, Chiara La Morgia, Claudia Priglinger, Rustum Karanja, Magali Taiel, José-Alain Sahel Feb 2025

Five-Year Outcomes Of Lenadogene Nolparvovec Gene Therapy In Leber Hereditary Optic Neuropathy, Patrick Yu-Wai-Man, Nancy Newman, Valérie Biousse, Valerio Carelli, Mark Moster, Catherine Vignal-Clermont, Thomas Klopstock, Alfredo Sadun, Robert C Sergott, Rabih Hage, Simona Degli Esposti, Chiara La Morgia, Claudia Priglinger, Rustum Karanja, Magali Taiel, José-Alain Sahel

Department of Neurology Faculty Papers

IMPORTANCE: Limited studies have assessed the long-term benefit/risk of gene therapy for Leber hereditary optic neuropathy (LHON).

OBJECTIVE: To determine the safety and efficacy of lenadogene nolparvovec in patients with LHON due to the MT-ND4 gene variant for up to 5 years after administration.

DESIGN, SETTING, AND PARTICIPANTS: The RESCUE and REVERSE Long-Term Follow-up Study (RESTORE), conducted from 2018 to 2022, is the 5-year follow-up study of the 2 phase 3 clinical studies RESCUE (Efficacy Study of Lenadogene Nolparvovec for the Treatment of Vision Loss Up to 6 Months From Onset in LHON Due to the MT-ND4 Mutation) and REVERSE …


University Of Northern Iowa's Strategic Plan 2023-28, University Of Northern Iowa Feb 2025

University Of Northern Iowa's Strategic Plan 2023-28, University Of Northern Iowa

Institutional Effectiveness & Planning Documents

Contents:

--- Our Values
--- Goal 1: Innovate for Learner Success
--- Goal 2: Access for All
--- Goal 3: Empower Communities to Shape Their Future
--- Goal 4: Steward Resources Effectively


Cleaning The Plastic Spring, Trip Johnson Feb 2025

Cleaning The Plastic Spring, Trip Johnson

Vanderbilt Law Review

Everyday plastic items typically display the chasing arrows symbol with a resin identification code. When seen on a plastic product, this seemingly insignificant trade combination causes the average consumer’s mind to confer unwarranted environmental benefits to the item. Plastic, unlike aluminum, glass, or paper, poses barriers to recycling that diminish a region’s recycling capabilities. Despite knowing most Americans lack the knowledge necessary to properly discard plastic waste, plastic-producing companies continue to plaster chasing arrows symbols and resin identification codes onto their products. Worse yet, these companies do so without explaining the available recycling opportunities or challenges associated with recycling most …


Survival By Selection: The Role Of Natural Selection In Developing Biological Radiation Defenses, Seyed Alireza Mortazavi, Ilham Said-Salman, Sami El Khatib, Parmis Taghizadeh, Seyed Mohammad Javad Mortazavi, Lembit Sihver Feb 2025

Survival By Selection: The Role Of Natural Selection In Developing Biological Radiation Defenses, Seyed Alireza Mortazavi, Ilham Said-Salman, Sami El Khatib, Parmis Taghizadeh, Seyed Mohammad Javad Mortazavi, Lembit Sihver

Informatics and Engineering Systems Faculty Publications

Natural selection, a cornerstone of evolutionary biology, shapes the adaptations organisms develop to survive environmental pressures. This paper explores how natural selection drives biological adaptations to radiation exposure. We examine the genetic mechanisms at play, exemplified by the enhanced DNA repair capabilities observed in bacteria like Escherichia coli (E. coli) following exposure to radiation. We then investigate adaptations in humans residing in high-background radiation areas, highlighting potential genetic variations for radiation resistance. Finally, the contemporary relevance of natural selection is discussed, emphasizing its role in the emergence of antibiotic-resistant bacteria and the need for sustainable medical practices. By studying these …


Integrating Kemira With Interval-Valued Neutrosophic Numbers To Assess University English Teaching Quality: A Multi-Attribute Decision-Making Model, Li Ding Feb 2025

Integrating Kemira With Interval-Valued Neutrosophic Numbers To Assess University English Teaching Quality: A Multi-Attribute Decision-Making Model, Li Ding

Neutrosophic Sets and Systems

Evaluating the quality of university English teaching is essential for improving learning outcomes. Key factors include teaching methods, curriculum design, and teacher-student interaction. Effective teachers use engaging approaches that help students develop skills in reading, writing, listening, and speaking. Tailored course content and regular feedback mechanisms, such as surveys and assessments, enhance learning efficiency and address challenges. Teachers' enthusiasm and ability to motivate students greatly influence the quality of teaching. Emphasizing practical communication skills prepares students for real-world applications. This paper introduces the KEmeny Median Indicator Ranks Accordance (KEMIRA) method, combined with interval-valued neutrosophic sets (INSs), to address multiple-attribute decision-making …


Spatiotemporal Trends In Anopheles Funestus Breeding Habitats, Grace R. Aduvukha, Elfatih M. Abdel-Rahman, Bester Tawona Mudereri, Onisimo Mutanga, John Odindi, Henri E.Z. Tonnang Feb 2025

Spatiotemporal Trends In Anopheles Funestus Breeding Habitats, Grace R. Aduvukha, Elfatih M. Abdel-Rahman, Bester Tawona Mudereri, Onisimo Mutanga, John Odindi, Henri E.Z. Tonnang

All Peer-Reviewed Publications

Effective identification and control of malaria vector larval breeding habitats are crucial for the management and eradication of malaria. Despite its importance, the last decade has seen a decline in data availability and intervention efforts due to reduced attention and prioritization. This study addresses the geographic data scarcity concerning Anopheles funestus larval breeding habitats in a malaria-prone region of western Kenya. Employing a two-step methodological approach, we integrated multi-criteria decision analysis (MCDA) and rule-based fuzzy logic analysis to evaluate the spatiotemporal similarity or divergence of these habitats. The analysis spanned a five-year interval, 2008, 2013, and 2018 with 2013 serving …


The Historical Role Of Westward Expansion Between American Museums And Indigenous Tribes, Erika Tenorio Feb 2025

The Historical Role Of Westward Expansion Between American Museums And Indigenous Tribes, Erika Tenorio

Theses

Erika Tenorio’s thesis explores the intersection of Westward Expansion, American museums, and Indigenous communities, analyzing how 19th- and 20th-century expansionist policies shaped museum collections and Indigenous representation. The study examines how the ideology of Manifest Destiny, rooted in the Doctrine of Discovery, justified the forced removal of Native Americans and facilitated the collection of Indigenous artifacts by museums. Many of these institutions, influenced by Western colonial perspectives, portrayed Native cultures as relics of the past rather than as living traditions.

The research incorporates postcolonial and decolonial methodologies to assess evolving narratives within museums, focusing on Indigenous sovereignty, repatriation efforts, and …


Data And Digitalization In Energy Efficiency Policy Design: The Case Of Singapore, Ishani Mukherjee, Diandrea Ho Feb 2025

Data And Digitalization In Energy Efficiency Policy Design: The Case Of Singapore, Ishani Mukherjee, Diandrea Ho

Research Collection School of Social Sciences

Overarching and broad policy goals for enhancing energy efficiency have existed globally over the last 50 years as a response to rising energy demands, heightening costs, and construction levels of residential and commercial buildings, and the associated rises in greenhouse gas emissions from energy use (Levine et al., 2007; World Bank, 2010). Buildings, in particular, have been widely recognized as offering the greatest potential for reducing energy use and related greenhouse gas emissions, followed by reduced energy consumption in manufacturing, appliances, electronic goods, and end-users of electricity (Levine, 2007; IEA, 2010). And while significant technological strides have been made globally …


Religion: Evolutionary Foundation For, Nicole Fellice Ko, Norman P. Li Feb 2025

Religion: Evolutionary Foundation For, Nicole Fellice Ko, Norman P. Li

Research Collection School of Social Sciences

Religion refers to a structured set of spiritual beliefs and rituals. Evolution refers to the process by which living organisms transform and develop over time. Religion—the belief in spiritual beings—influences nearly every aspect of life, making it challenging to understand many phenomena without considering its influence (Bloom, 2012). About two-thirds of the world’s population is religious (Kramer & Tong, 2024); 70% of Americans consider themselves spiritual, and 83% believe they have a spirit separate from their bodies (PEW Research Center, 2023). Throughout history, religion has played a significant role in conflicts like war and continues to influence contemporary issues such …


Taming Biological Complexity Through The Use Of Symmetries, Luis A. Álvarez-García Feb 2025

Taming Biological Complexity Through The Use Of Symmetries, Luis A. Álvarez-García

Dissertations, Theses, and Capstone Projects

The study of biological systems is, inherently, the study of very complex systems. This is essentially due to the fact that they are made up of numerous, often very complicated, interactions between an extensive number of components. Often necessitating an abundance of quantitative parameters and details for a precise description. The human brain for ex- ample, consisting of ∼ 80 billion neurons with ∼ 800 to 100 trillion connections between them, each of them depending on a large set of parameters. Even simpler examples such as bacterial organisms, such as E. coli and B. subtilis, which we focus on …


Whose Innovation? Philanthropic And School-Based Visions Of High School In The Xq Super School Competition, Brett G. Murphy Feb 2025

Whose Innovation? Philanthropic And School-Based Visions Of High School In The Xq Super School Competition, Brett G. Murphy

Dissertations, Theses, and Capstone Projects

The XQ Institute, funded by Laurene Powell Jobs’ Emerson Collective, launched a design competition in 2015 to find the most innovative high schools in the country. Their goal was to spark a movement that would revolutionize secondary school in the United States, a system they claimed was 100 years behind the times. Called the Super School Project, the winning ten teams each received $10 million. While XQ claims that the best ideas about high school reform come from communities and student voice, they also have funded selective ideas about “innovation,” including computer-based personalized learning. The organization’s efforts have grown in …


Evidence For Interactive Effects Of Inhibitory And Prospective Intolerance Of Uncertainty And Stimulus-Level Uncertainty On Threat Safety Discrimination Learning, Kyoko Yazaki Feb 2025

Evidence For Interactive Effects Of Inhibitory And Prospective Intolerance Of Uncertainty And Stimulus-Level Uncertainty On Threat Safety Discrimination Learning, Kyoko Yazaki

Dissertations, Theses, and Capstone Projects

Fear is a fundamental component of human learning, critical for survival, and extensively studied through Pavlovian conditioning paradigms (LeDoux & Pine, 2016). This thesis examines the interplay between stimulus-level uncertainty and individual differences in intolerance of uncertainty (IU) on threat-safety discrimination learning. Using a within-subject design, participants were conditioned to certain (100% reinforcement), uncertain (50% reinforcement), and safety (0% reinforcement) cues through the pairing of colored visual stimuli with aversive electrical shocks. Discrimination learning was assessed using both implicit (SCR) and explicit (self-reported US expectancy estimates and unpleasantness ratings) measures.

The present study (n = 102) replicated previous findings showing …


Development Of Soil Survey Methods For Urban Areas, Kohinoor Begum Feb 2025

Development Of Soil Survey Methods For Urban Areas, Kohinoor Begum

Dissertations, Theses, and Capstone Projects

Urban soils are the foundation of urban ecosystems and play a vital role in long-term urban sustainability and resiliency. Accurate soil surveys of urban areas should be done at higher resolution since extensive human activities often result in urban soil being highly disturbed and spatially variable. Besides heterogeneity, one of the unique and challenging aspects of urban soil is the nature and properties of its organic carbon with a significant percentage of black carbon (a particulate product of incomplete combustion), which is less biologically active. Thus, in order to determine the ability of a soil to support biological activity and …


Constructing Women Who Do Not Reproduce In Global Neoliberalism: Critical Approach To The Abolition Of Legal Ban On Abortion And The Struggle In South Korea, Yumi Kwon Feb 2025

Constructing Women Who Do Not Reproduce In Global Neoliberalism: Critical Approach To The Abolition Of Legal Ban On Abortion And The Struggle In South Korea, Yumi Kwon

Dissertations, Theses, and Capstone Projects

This study historically examines the abolition of the legal ban on abortion and the struggle in South Korea, focusing on the construction of the status of “women who do not reproduce”, and accordingly aims to critically analyze how neoliberal reproductive crisis in South Korea has been reorganized into the new order through the constitutive role of the struggle.

The results of the analysis are as follows: First, by examining Fraser’s theory, I explain that when the “boundary” dividing the realms of production and reproduction is a place of contradiction and struggle, the phenomenon of women not reproducing is centrally located …


Modernity And The Promise Of Democracy: A Democratic Reading Of Machiavelli And Hobbes, Gabriel Garber Feb 2025

Modernity And The Promise Of Democracy: A Democratic Reading Of Machiavelli And Hobbes, Gabriel Garber

Dissertations, Theses, and Capstone Projects

A review of the democratic scholarship on Niccolò Machiavelli and Thomas Hobbes reveals a tension between institutional and anti-institutional democratic interpretations. This reflects a knot in democracy itself. Miguel Vatter’s labels this knot ‘form and event’ in his democratic interpretation of Machiavelli. Machiavelli’s theory of form and event comes through an exploration of the tensions between structure, agency, rhetoric, and radical openness in the political realm. For Hobbes, the radically egalitarian state of nature produces one first and final event (the social contract) towards a world of strict form. The democratic interpreters have best noticed the tension between form and …


Quantified Lives: Data, Bias, And The Cost Of Categorization, Colin F. Geraghty Feb 2025

Quantified Lives: Data, Bias, And The Cost Of Categorization, Colin F. Geraghty

Dissertations, Theses, and Capstone Projects

This project critically examines how statistical methods and data visualization have historically been used to categorize, rank, and control human populations. By exploring the works of key figures like Francis Galton, Karl Pearson, and R.A. Fisher, it traces the evolution of categorization frameworks from their eugenic roots to modern applications in artificial intelligence and global metrics like the World Happiness Report. Through interactive visualizations and historical analysis, the project invites users to question the legitimacy of these frameworks and reflect on their impact on society. At its core, this work emphasizes the need to move beyond rigid classification systems, challenging …


Unifying Comprehension And Competence Through Merge: A New Linking Hypothesis Connecting Electrophysiological Data To Linguistic Intuitions, Kevin Patrck Guzzo Feb 2025

Unifying Comprehension And Competence Through Merge: A New Linking Hypothesis Connecting Electrophysiological Data To Linguistic Intuitions, Kevin Patrck Guzzo

Dissertations, Theses, and Capstone Projects

This dissertation integrates neuroscience and linguistics to investigate the cognitive mechanisms underlying syntactic processing. To do this, we focus on Early Syntactic Negativities (ESNs) which are rapid negative electrophysiological responses known to be elicited by phrase structure violations due to an unexpected lexical category. We examine ESNs elicited in two previously undocumented elliptical constructions, sluicing and swiping, employing event-related potentials (ERPs) and behavioral acceptability judgments. Our investigation builds upon Collins and Stabler’s (2016) formalization of minimalist syntax, proposing a novel Merge Hypothesis of ESNs. This hypothesis posits a direct link between ESNs and violations of the Merge operation, a fundamental …


Solvation Thermodynamic Mapping Approaches For Computer-Aided Drug Discovery, Vjay Molino Feb 2025

Solvation Thermodynamic Mapping Approaches For Computer-Aided Drug Discovery, Vjay Molino

Dissertations, Theses, and Capstone Projects

The drug discovery process is inherently long and costly, prompting the development and integration of computational tools to mitigate these challenges. One of area explored in computer-aided drug discovery is to understand the role of solvation in protein-drug binding and to develop computational tools and methods that can be integrated in the drug discovery process. Grid Inhomogeneous Solvation Theory (GIST) is a tool that provides a framework for mapping solvation thermodynamiproperties of water molecules on the protein surface.This thesis explores the use of GIST in generating pharmacophore models and elucidates the role of solvation in protein structural fluctuations.

One of …