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Multiple Molecular Diagnoses Identified Through Genome Sequencing In Individuals With Suspected Rare Disease, Jorge Perez

All Publications

Genome sequencing is a powerful and comprehensive test that detects multiple variants of different types. The interrogation of variants across the genome enables the identification of multiple molecular diagnoses (MMDs) in a single individual. In this retrospective study, we describe individuals in whom MMDs were associated with the proband's indication for testing (IFT), secondary findings, or incidental findings. An MMD is considered where at least one of the findings is associated with the primary IFT and all variants are classified as either likely pathogenic or pathogenic. Clinical genome sequencing was performed for all individuals as part of the iHope program …

The Art And Science Of Naval Warfare: Essays In Memory Of Wayne P. Hughes Jr., Mie Augier, Sean F. X. Barrett, William F. Mullen Iii

Newport Papers

Retired Navy captain Wayne P. Hughes left an indelible mark on the U.S. Navy after a lifetime of service. The author of Fleet Tactics was outspoken in his determination to better the service to which he dedicated his life, throughout his Navy career and carrying through to his time teaching at the Naval Postgraduate School in Monterey, California. Following his passing on 3 December 2019 at the age of eighty-nine, Hughes's colleagues, students, and friends gathered virtually in June 2021—on what would have been his ninetieth birthday—to discuss his career, fleet tactics, and the lasting impact of his work. Collected …

Mitigation Of Micro-Nano Plastics Facilitated Using Microbial And Nanophotonic Degradation, And Smart Material Designs, Ashok Vaseashta, Surik Khudaverdyan, Gor Gevorgyan, Ioan Stamatin, Shushanik Kazaryan, Ashkhen Hovhannisyan, Susanna Tiratsuyan, Ludmila Sidorenko, Tatiana Gutul, Inna Rastimesina, Anatolie Sidorenko

Micro-Nano Plastics in Water: Characterization, Cure and Prevention

Please click Additional Files below to see the full abstract

Academic Year 2025–26 Annual Estimate Of The Strategic Security Environment, Us Army War College

Books, Monographs & Collaborative Studies

Maintaining strategic advantage demands professional discourse from across the force. The Academic Year 2025–26 Annual Estimate of the Strategic Security Environment provides a framework for those aspiring to tackle the Department of Defense’s most pressing challenges. This year’s authors highlight trending challenges and identify potential tension points across 15 sections organized into four enduring themes. This survey of regional, domestic, and institutional challenges represents the collective expertise of the US Army War College. The narrative is supplemented by a tailored list of 100 command-sponsored questions from 43 different Army and Joint organizations from across the Department of Defense. Combined, the …

2025 O'Callahan Society Newsletter, O'Callahan Society, College Of The Holy Cross

O'Callahan Society Newsletters

This annual newsletter of the O'Callahan Society includes articles about the 2024 O'Callahan Society Fall Dinner. Lieutenant Colonel Kevin Schmiegel, United States Marine Corps (Retired) and Holy Cross Class of 1989 was the guest speaker. VADM Nancy S. Lacore, HC ‘90 was 2025 Annual Meeting Speaker. Unit News. Alumni News. Society News.

The Orb’S Eye: Seeing The National Security Implications Of Iris Based ‘Proof Of Humanity’, Elise Annett, James M. Keagle, James Giordano

Strategic Insights

This commentary examines the national security implications of iris-based biometric identity systems such as “The Orb,” a device designed to verify human users in an AI-saturated digital environment. While proof-of-personhood technologies may help counter synthetic media, bot networks, and AI-driven disinformation, the authors argue that centralized biometric identity infrastructures create significant strategic vulnerabilities. Risks include surveillance, coercion, identity forgery, cyber-espionage, financial manipulation, and potential use in cognitive warfare or critical infrastructure disruption. The article outlines governance and security recommendations to mitigate dual-use threats. Orb-like systems could either strengthen democratic resilience or become instruments of strategic influence, depending on how they …

U.S. Withdrawal From Afghanistan And Realignment Of Eurasian Rival Powers, Toghrul Seyidbayli

Journal of Strategic Security

This article explores the geopolitical ramifications of the U.S. withdrawal from Afghanistan, focusing on how it has catalyzed strategic realignments among China, Russia, and Iran in Eurasia. By examining the withdrawal’s impact on the regional power dynamics, the article analyzes how these revisionist states have exploited the resulting power vacuum to assert their influence and challenge the existing international order. China has used this moment to expand its Belt and Road Initiative, Russia has felt emboldened to escalate its military actions in Ukraine, and Iran, despite regional setbacks, remains determined in pursuing its revisionist strategy in Eurasia. The study employs …

China-Taliban Security Ties: A Reimagining Of South Asia's Security Discourse, Amit Kumar Mr., Veena Ramachandran

Journal of Strategic Security

This article examines how China constructs a distinct security discourse on terrorism through its engagement with the Taliban in Afghanistan. Moving beyond traditional materialist interpretations of security, the study draws on critical security studies to explore how China uses language, representation, and institutional practices to frame terrorism and project itself as a regional stabilizer. The Taliban’s return to power in 2021 has prompted China to expand its strategic presence in South Asia, particularly through economic diplomacy, intelligence cooperation, and regional multilateral and minilateral forums. Through qualitative discourse analysis of Chinese official statements, white papers, SCO documents, and state media narratives, …

Furthering The Legacy Of Benjamin B. Ferencz: Amending The Rome Statute’S Jurisdiction Over The Crime Of Aggression, Jennifer Trahan

Cardozo International & Comparative Law Review

The article advocates for amending the Rome Statute to strengthen the International Criminal Court's (ICC) jurisdiction over the crime of aggression. It argues that the current jurisdictional regime, established by the 2010 Kampala amendments, is too limited, creating double standards and undermining the rule of law. The author calls for harmonizing the ICC's jurisdiction over the crime of aggression with its jurisdiction over other crimes, such as genocide and war crimes, to ensure consistent and universal accountability.

Bodies Are Not Battlegrounds: Sexual And Gender-Based Violence As A War Tactic: A Ukrainian Case Study, Marina Coriale

Cardozo International & Comparative Law Review

The note examines the use of sexual and gender-based violence (SGBV) as a weapon of war, with a focus on conflict-related sexual violence (CRSV) in Ukraine. It highlights the legal frameworks and precedents established by international courts and tribunals, such as the Rome Statute, the ICTY, and ICTR, to prosecute CRSV as war crimes, crimes against humanity, and genocide. The analysis underscores the challenges faced by survivors in seeking justice and the importance of addressing root causes like gender inequality. It advocates for strengthened legal mechanisms, accountability, and reparations to promote healing and deter future atrocities.

Learning From Afghanistan: The Futility Of Occupation In Nation-Building, Jithin Raveendran

Journal of Strategic Security

This article explores the challenges and failures of nation-building under occupation Amidst an active warfare, using Afghanistan as a critical case study. Over two decades, the US-led intervention sought to establish stability and democracy but ultimately faltered due to misaligned strategies and systemic flaws. Efforts to impose Western governance structures clashed with Afghanistan’s deeply rooted tribal and cultural norms, fueling resistance and eroding legitimacy. The article identifies key shortcomings, including the neglect of local agency, cultural insensitivity, over-reliance on military solutions, and the perpetuation of dependency and corruption. It argues that nation-building by occupying forces is inherently flawed without prioritizing …

Afghanistan: Taliban’S Second Chance And Red Strategy, Oleg Golishnikov

Journal of Strategic Security

An objective evaluation of Afghanistan’s political and socioeconomic situation since the Taliban’s takeover in August 2021 is crucial for understanding and addressing security issues at the national, regional, and global levels. Unlike most studies, this article provides new insights, offering a balanced assessment of the situation in Afghanistan and developing recommendations on dealing with the Taliban regime. By employing qualitative methods and a rational theory framework, this article argues that Afghanistan under Taliban rule is experiencing a mix of positive and negative trends. Major positive trends include the relative peace in Afghanistan, the Taliban’s real power and control over the …

2025 July, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for July of 2025.

From Nation-Building To Collapse: Analyzing Afghanistan’S 2021 Fall And The Geopolitical Entropies Of U.S. Withdrawal, Arash Beidollahkhani, Edriss Rasa

Journal of Strategic Security

The collapse of the Afghan government in 2021 and the subsequent return of the Taliban marked a significant shift in contemporary geopolitics. This paper examines the political and social dynamics surrounding the U.S. and allied forces' withdrawal, focusing on the entropic forces that contributed to the breakdown of Afghanistan’s governance system. While Afghanistan has experienced recurrent governmental collapses, the post-2021 crisis highlights deeper structural challenges within both the geopolitical and domestic spheres. The research investigates the failure of the U.S.-backed Afghan government, established through two decades of nation-building efforts, and explores how the abrupt foreign withdrawal dismantled fragile political structures, …

Fostering Human Rights Awareness In Kosovo: A Case Study On The Sustainability Of Ngo Trainings, Hana Kaja

Theses

The sustainability of human rights trainings in Kosovo remains a critical issue, particularly as the country seeks to develop a rights-oriented society aligned with Euro-Atlantic values. This case study evaluates the sustainability efforts of two trainings conducted by a non-governmental organization, focusing on their alignment with objectives, participant feedback, and systemic factors such as institutional support and follow-up mechanisms. It also explores broader challenges like participant disengagement and the limited integration of human rights education into the national curriculum. A mixed-methods approach was used, combining survey data from participants, interviews with NGO representatives, and analysis of internal documents. To ensure …

Exploring Kosovo's Need For A Technology-Driven Offset Strategy, Alba Cikaqi

Theses

At a time where technological innovation is redefining national security, Kosovo risks falling behind by failing to adopt emerging technologies for defense and security. This research addresses that vulnerability by exploring the need for a dedicated national strategy as a solution. Drawing on global best practices, including the United States Offset Strategy, NATO frameworks, and innovation models from the Baltic countries, the study outlines a potential path forward. Additionally, through qualitative analysis, including interviews with key stakeholders across public, private, and academic sectors, this study looks into the opportunities and challenges of developing a context-specific strategy for integrating emerging technologies …

Assessing The Benefits Of Simulations And War Games For The Homeland Security Enterprise Workforce, David Schanzer, Daveed Gartenstein-Ross, Jessica Sperling, Victoria Lee, Elena Johanson, Eleanor Ross

Reports, Projects, and Research

In recent years, there has been great interest across government, academia, and the private sector in experiential learning, and in particular the use of simulation and game-based methodologies. The purpose of this project is to use rigorous social science research to assess the educational value of simulation-based experiential learning and provide a replicable evaluation model that allows for validation and extension by other scholars and practitioners.

This report helps to fill the gaps in understanding the specific educational and training advantages offered by games, as well as the best practices for employing games to train or educate members of the …

Introduction To Collective Neutrosophy And Collective N-Ary Neutrosophy, Florentin Smarandache

Neutrosophic Sets and Systems

No abstract provided.

Book Review: Provoked: How Washington Started The New Cold War With Russia And The Catastrophe In Ukraine, Josh Vanbuskirk

Parameters Bookshelf – Online Book Reviews

Author: Scott Horton

Reviewed by Lieutenant Colonel Josh VanBuskirk, commander, 6th Battalion, 95th Regiment, San Antonio, Texas

Billed by the reviewer as “must-read for military professionals who want to understand how the United States and Russia came to the precipice of war,” this book posits that the Washington bipartisan foreign policy consensus is to blame for the Russia-Ukraine War. Using US diplomats, bureaucrats, defense contractors, and politicians to make his point, Horton uses their work to argue for restraint when dealing with Russia.

©2025 Josh VanBuskirk

Book Review: The War For Ukraine: Strategy And Adaptation Under Fire, Jonathan P. Klug

Parameters Bookshelf – Online Book Reviews

Author: Mick Ryan

Reviewed by Dr. Jonathan P. Klug (colonel, US Army, retired), course integrator, Theater Army Staff Course, Center for Strategic Leadership, US Army War College

Mick Ryan’s book The War for Ukraine: Strategy and Adaptation Under Fire examines Russia’s and Ukraine’s strategies and, and Ukraine’s NATO supporters, “exploring how the Russians and Ukrainians adapted during the war—on the battlefield and institutionally.” The book has two parts. Part one explores strategy. Part two discusses adaptation in the Russia-Ukraine War and includes points about adaptation for future wars. The reviewer sees it as a must-read saying, “The War for Ukraine …

Vocabulary Learning Strategies Among Saudi Efl Military Cadets: Patterns And Preferences, Fahad Aldosari

Language, Literacy, and Sociocultural Studies ETDs

This study investigates the vocabulary learning strategies (VLSs) of 126 Saudi military EFL cadets, an underexplored group in second language acquisition research. Using an explanatory sequential mixed-methods design, a questionnaire identified the most and least used strategies, followed by interviews with 10 participants for deeper insights. Findings show cadets frequently use bilingual dictionaries, vocabulary lists, and group work, while cognitive strategies like written repetition and note-taking are underutilized. No significant differences in VLS use were found between Level 1 and Level 2 cadets, suggesting stable strategy preferences. Additionally, emerging strategies such as gamified learning and collaborative storytelling indicate a shift …

Fishing In Troubled Waters: Chinese Violations Of Filipino Fishers' Right To Food, Andrew Parco

Connecticut Journal of International Law

This Article explores the current maritime dispute between China and the Philippines through a human rights lens, focusing on the right to adequate food for small-scale Filipino fishers. Fishing in the SoutheastAsia Sea holds a distinct place in Filipinos' culture, tradition, and economic wellbeing, but it is most important as a food source for coastal communities. Despite this crucial role and despite the decision of an arbitration tribunal China's coast guard and maritime militia have continued to harass and intimidate Filipino fishing vessels. The right to adequate food is recognized in multilateral agreements, United Nations resolutions, and customary international law, …

Quantum Simulation Of Molecular Dynamics Processes─A Benchmark Study Using A Classical Simulator And Present-Day Quantum Hardware, Tamila Kuanysheva, Brian K. Kendrick, Lukasz Cincio, Dmitri Babikov

Chemistry Faculty Research and Publications

We explore how the fundamental problems in quantum molecular dynamics can be modeled using classical simulators (emulators) of quantum computers and the actual quantum hardware available to us today. The list of problems we tackle includes propagation of a free wave packet, vibration of a harmonic oscillator, and tunneling through a barrier. Each of these problems starts with the initial wave packet setup. Although Qiskit provides a general method for initializing wave functions, in most cases it generates deep quantum circuits. While these circuits perform well on noiseless simulators, they suffer from excessive noise on quantum hardware. To overcome this …

United States Governmental Assessments Of The Rise Of Communism In And Around The Republic Of South Africa, Stuart Ledbetter

Voces Novae

No abstract provided.

Faith On The Frontlines: Exploring The Religiosity Of Ukrainian Soldiers During War, Alexander Karlsson

Occasional Papers on Religion in Eastern Europe

Wartime religiosity among Ukrainian Christian soldiers reveals a spectrum of spiritual responses shaped by personal experience, cultural identity, and institutional dynamics. Interview-based evidence indicates that war influences religious engagement in diverse and often contradictory ways. For many, religiosity intensifies during moments of danger, functioning more as a coping mechanism than a transformation of belief. Institutional realignment may also reflect broader socio-political changes, as soldiers gravitate toward religious communities that resonate with their evolving values. For some, the adoption of Norse mythology illustrates the fluidity and adaptability of religious identity in wartime. Simultaneously, confrontations with theodicy may give rise to both …

Hybrid War: The Influence Of The Russian Orthodox Church On The Ukrainian Media, Oksana Lytvynchuk, Andrii Shevchuk, Zoriana Hrytsyshena

Occasional Papers on Religion in Eastern Europe

This article examines the Russian Orthodox Church (ROC) as a key instrument of hybrid warfare against Ukraine. It analyzes the ROC's primary strategies for influencing Ukraine's information space, particularly through religious rhetoric manipulation and the exploitation of ecclesiastical structures to disseminate pro-Kremlin narratives. The study identifies key mechanisms of the ROC's media influence, including direct control over religious media outlets, active participation of clergy in promoting Russian propaganda narratives, financial backing of pro-Russian media projects, and systematic disinformation campaigns about Ukraine's religious landscape.

Key findings demonstrate the destructive consequences of this hybrid warfare: exacerbation of interfaith tensions leading to societal …

Grundnorm, Pure Theory Of Law, And Monism In The Dynamics Of International Law, Fx Adji Samekto, Muh. Afif Mahfud, Adya Paramita Prabandari

Indonesian Journal of International Law

The Grundnorm is Hans Kelsen’s teaching that was integrated into his theory known as the Pure Theory of Law. The Grundnorm is the highest source of legal imperative, which is accepted by every individual human being, based on his free will to submit orders that are no longer debated because they are accepted as truth. The Grundnorm being the source of the validity of legal imperatives, it means that is the highest source of the validity of regulatory law within the scope of national and international law. This is the background of the justification of the Monism school, which is …

The Default Option As A Nudge In Shaping Individual Decisions Under Competitive And Cooperative Conditions: An Experimental Study, Marta Sylwestrzak

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: Overbidding in competitive settings leads to resource wastage and limits potential social benefits from cooperation. This study examines how the prize structure of two types of tournaments, winner-take-all (WTA) and proportional prize (PP), and default options as behavioural nudges influence expenditure levels among paired participants. The obtained results can have practical applications in designing competitive mechanisms, such as incentive programs in organizations, to minimize resource waste and promote more efficient participant behaviour.

Methodology: The laboratory experiment involved 78 participants competing in pairs across four conditions: WTA and PP, with or without default options. Data were analyzed regarding expenditures.

Results: …

The Problem Of Staffing In Employment, Karolina Czapska-Małecka

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: The main goal of the research is to attempt to comprehensively present the problem of staffing, which is the least common form of mobbing. The publication includes legal, psychological and managerial aspects of this phenomenon, as well as methods of counteracting this form of violence.

Methodology: The research scope of the article is the problem of mobbing and its variety, i.e. staffing. The source material consisted of the case law of the Supreme Court and the Courts of Appeal in the field of mobbing and staffing. The article also used statistical data, commentaries on the Labor Code, as well …

America First: Make Nato Great Again, Matthew Thomas Becker

Faculty and Student Publications

This guest editorial appeared in multiple venues:

1. The Clarion Ledger (online: 7/8/2025, print: 7/13/2025)
2. The Commercial Dispatch (6/26/2025)
3. Hattiesburg American (7/8/2025)
4. Magnolia Tribune (7/1/2025)
5. USA Today (7/8/2025)
6. Press Reader (7/13/2025)