Digital Commons Network^™

Task-Aligned Haze Removal With Semantic-Aware Fusion And Contrast Self-Correction, Jinbin Wang, Aiping Yang, Guosong Jiang, Wenlong Yu, Dongwei Ren, Qinghua Hu

Research Collection School Of Computing and Information Systems

Adverse haze conditions introduce complex degradations that obscure scene details and distort structural cues critical for object detection, posing persistent challenges for vision‐based sensing systems. Although existing haze removal methods have achieved notable improvements in visual clarity, their optimisation objectives are often misaligned with downstream detection requirements, leading to limited detection performance in real‐world scenarios. To address this issue, this work proposes a task‐aligned weakly supervised haze removal framework, termed Dehaze4Detection, which explicitly aligns low‐level restoration with high‐level detection objectives. The framework incorporates a Semantic‐Aware Multi‐Scale Fusion Module (SMFM) that embeds pixel‐level semantic knowledge into the dehazing process, enabling selective …

Parameterized Approximation Schemes For Fair Clustering In Doubling Metrics, Xiaoliang Wu, Ting Liang, Zhize Li, Qilong Feng

Research Collection School Of Computing and Information Systems

Fair clustering has garnered considerable attention, with various fairness notions proposed to ensure equitable representation across demographic groups. In this paper, we focus on the k-center problem in bounded doubling metrics under two popular fairness requirements: group fairness and data summarization fairness, referred to Group Fair k-Center (Gf-k-Cen) and Data Summarization Fair k-Center (Dsf-k-Cen), respectively. Both fairness notions extend classical clustering formulation by associating each data point with a demographic label. Motivated by recent advances in parameterized approximation results for fair clustering, we investigate whether these problems admit Fixed-Parameter Tractable (FPT) approximation schemes in bounded doubling metrics. The previous algorithms …

Corruption Is Futile: Hardware-Assisted Multi-User Searchable Encryption, Feng Li, Chengyan Ma, Xiaoguo Li, Pengfei Wu, Lisha Yao, Jianting Ning, Guomin Yang, Jianfeng Ma, Deng, Robert H.

Research Collection School Of Computing and Information Systems

Searchable encryption enables writers to upload encrypted data to an untrusted cloud server, while allowing authorized readers to perform keyword searches over the encrypted content without compromising data privacy. The multi writer/multi-reader (M/M) setting better reflects real-world de ployment requirements because it aligns with the collaborative nature of many modern applications, but introduces substantial challenges in both efficiency and security. The state-of-the art scheme, delegatable searchable encryption (DSE), achieves optimal search time and forward privacy in the M/M setting. Nevertheless, DSE provides only limited security guarantees: search tokens generated by readers reveal the update count of queried keywords, and the …

Medical Firms’ Online Q&A Interactions: Effect Of Language Style On Investor Engagement, Runyu Wang, Keng Siau, Zili Zhang

Research Collection School Of Computing and Information Systems

PurposeThis study aims to investigate how language styles used by medical firms on digital question and answer (Q&A) platforms influence investor engagement. It examines the linguistic characteristics of managerial responses and compares their effects across industries, with a focus on the distinctive demands of medical communication.Design/methodology/approachWe analyze a panel dataset of 1,223 firm-month observations, constructed from 13,549 individual responses provided by 70 medical firms on a major Chinese web-based firm-investor Q&A platform over a 24-month period (2020–2021). Content analysis is used to assess linguistic features, such as first-person usage, uncertainty, understandability and concreteness. A two-way fixed effects model with clustered …

Biomolecular Corona Of Extracellular Vesicles: Report On Isev Workshop, Lucia Paolini, Selene Tassoni, Khuloud T. Al-Jamal, Xavier Banquy, Tamás Beke-Somfai, Paolo Bergese, Fanni Annamária Boros, Massimo Bottini, Ben Boyd, Sara Busatto, Benedetta Bussolati, Ester Canepa, Valentina Castagnola, Aled Clayton, Kenneth Dawson, Samir El-Andaloussi, András Försönits, Orazio Fortunato, Roberto Frigerio, Martina Gabrielli, Cristina Grange, Michele Guescini, Yuya Hayashi, Jonas Klejs Hemmingsen, Seungmin Kim, Ilyes Kinga, Heikki Kyykallio, Metka Lenassi, Luize Goncalves Lima, Mỹ G. Mahoney, Camille Menaceur Vandenbroucke, Andreas Möller, Angelo Musicò, Inge Nelissen, Lucas Fabrício Bahia Nogueira, Christa Nöhammer, Pietro Parisse, Charles Ramassamy, Kelly Cristine Santos Roballo, Anna Salvati, María Sancho-Albero, Ganesh Shelke, Paniz Shirmast, Tasvilla Sonallya, Imola Csilla Szigyártó, Monique A. J. Van Eijndhoven, Tapani Viitala, Shan Wang, Yan Yan, Andrea Zendrini, Edit Buzás, Annalisa Radeghieri

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

The concept of the "biomolecular corona" (BC) was first introduced to describe the spontaneous absorption of molecules, mainly proteins, onto the surface of synthetic nanoparticles upon exposure to biological fluids. More recently, the same term has been used to describe biomolecules that dynamically interact with the surface of extracellular vesicles (EVs) during their biogenesis, secretion, or upon exposure to intracellular or extracellular milieus, including biological fluids. The EV biomolecular corona is a key determinant of EV identity, shaping their cellular uptake, biodistribution, and functional outcomes in both physiological and pathological contexts. EVs, in contrast to synthetic nanoparticles, introduce distinct challenges …

Nanostructured Negative Electron Affinity Gallium Arsenide Photocathodes With Enhanced Quantum Efficiency And Extended Charge Lifetime For Advanced Photoinjectors, Md Aziz Ar Rahman

Physics Theses & Dissertations

This dissertation presents a comprehensive experimental and computational investigation of nanostructured negative electron affinity (NEA) gallium arsenide (GaAs) photocathodes. This work was undertaken to achieve higher quantum efficiency (QE) and longer charge lifetime than conventional flat NEA GaAs electron sources commonly used in photoinjectors. Finite-Difference Time-Domain and charge-transport simulations of three types of nanostructure geometries reveal substantial QE enhancement over flat GaAs via Mie resonance mode excitation. Consequently, the truncated nanocone array (TNCA) photocathodes with heights of 400, 700, and 1000 nm were fabricated and NEA activated via Cs-NF₃ deposition. In a low-voltage ultra-high vacuum chamber with a base pressure …

Naturalistic Classroom And Home Practices To Support Executive Function And Self-Regulation Of Typically Developing Preschool Children Between The Ages Of 3-5 Years Old: A Mixed Method Study, Michelle Ann Burek

Rehabilitation Sciences Theses & Dissertations

Executive function (EF) and self-regulation (SR) are foundational developmental processes supporting young children’s participation in play, learning, social relationships, and everyday occupations. Although important to school readiness, social competence, health, and well-being, these skills are often examined in structured settings rather than the natural environments in which children develop. Guided by ecological, developmental, and occupational therapy perspectives, this dissertation examined EF and SR within children’s everyday participation and explored caregiver and teacher roles in supporting these processes.

This dissertation consists of three interconnected studies. The first was a systematic review of peer-based interventions to improve social participation among children and …

I Was There, I Belonged There, And I Should Be There: The Adult Student Experience In Community College Courses Filled With High School Students, Charles Douglas Bowling

Educational Leadership & Workforce Development Theses & Dissertations

The rapid expansion of dual-enrollment and early college high school programs in North Carolina has led to a substantial increase in the numbers of dual-enrolled high school students in community college classrooms. This exploratory case study examined how adult students described their experiences in university-transfer courses in which dual-enrolled high school students make up the majority of the class. It also examined how some of these adult students’ instructors described the experiences of these adult students.

The current study was conducted at three community colleges in rural counties in southern Appalachia and included semi-structured interviews with 18 adult students (24-60 …

Exploring The Experiences Of Women In Mental Health Therapy After The Occurrence Of Perinatal Loss, Courtney Allison Nishnick

Counseling & Human Services Theses & Dissertations

Perinatal loss encompasses losses of pregnancies at any gestational age, as well as deaths occurring within one year post-birth. In the United States, around 40 thousand stillbirths and infant deaths occur every year (Ely & Driscoll, 2025; Gregory et al., 2025), with about 23 million miscarriages also occurring annually worldwide (Quenby et al., 2021). Perinatal loss experiences lead to distressing mental health symptoms not limited to anxiety, depression, posttraumatic stress, and grief (Crockett et al., 2019; Wamser & Ferro, 2025). While there is extensive research on perinatal loss as it pertains to medical context, there is minimal research relating to …

Becoming An Educator: A Narrative Inquiry Into The First-Year Journeys Of Community College Career-Switching Cte Faculty, Alisha Ferrington

Educational Leadership & Workforce Development Theses & Dissertations

Career and Technical Education (CTE) programs in community colleges increasingly depend on career-switching instructors, professionals who transition from industry to teaching with substantial technical expertise but limited formal pedagogical preparation. Despite their growing presence in the community college workforce, the lived experiences of first-year career-switching CTE faculty remain underexplored, particularly regarding how the transition shapes professional identity, instructional practice, and institutional belonging.

This qualitative study employed narrative inquiry to examine the first-year teaching experiences of seven career-switching CTE instructors at community and technical colleges in the Gulf South region of the United States. Guided by transformative learning theory, communities of …

Decarbonizing The C3 Splitter: Performance Optimization And Environmental Impact Of Mvr Integration, Dalia A. Ali Associate Prof.

Chemical Engineering

Due to the relatively low volatility (α) of propane and propene components, their separation is one of the most energy-intensive processes in the petrochemical industry. This study evaluates the technical, environmental and thermodynamic performance of a mechanical vapor recompression (MVR) heat pump integrated into a C3 splitter, compared to a conventional steam-heated distillation column. A sensitivity study was conducted using Aspen Plus software at different pressures, reflux ratios (RR) and at turndown operations. According to the results, the MVR system uses a compressor to raise the overhead vapor pressure to 38.7 bar to operate the heater without the need for …

Paperless Society, Paperless Future And Borderless Libraries, Ukoha O. Igwe

Library Philosophy and Practice (e-journal)

Purpose: This study explores the indispensability of books and physical libraries despite the digital technologies and digital transformation engulfing our lives, work and society.

Design/Methodology: This study used qualitative design and methodology utilizing a systematic review and synthesis of empirical research, institutional reports and documents published between 1978 and 2025 to achieve its objectives. An extensive review of the pertinent literature was undertaken to underscore the journey and permutations of the death of books and libraries. This conceptual review synthesizes the interplay between digital technologies, digital transformation,and libraries in information dissemination. This provided a basis for inferences and extrapolation of …

Multi-Dimensional Framework For Industry 5.0: Integrating Human-Centric, Sustainability, And Operational Resilience, Tamer Adel Mohamed, Mohamed Boumalkha, Ahmed S.I. Amar

Mechanical Engineering

Industry 5.0 reframes digital transformation as a socio-technical endeavor in which automation serves human capabilities, environmental limits, and operational continuity. Yet, much of the current discourse remains either conceptual—lacking implementable metrics—or technologycentric— treating humans and sustainability as constraints instead of design objectives. This paper develops a multi-dimensional implementation framework that operationalizes the three pillars of Industry 5.0: human-centricity, sustainability, and operational resilience. We synthesize recent advances in collaborative robotics and safety-aware human–robot collaboration, digital twins (including human and supply-chain twins), and AI-driven decision support—augmented by emerging 6G ultra-reliable low-latency networking capabilities such as reconfigurable intelligent surfaces, terahertz communications, multi-access edge …

Sem-Pdpl: Semantic Exposure Graphs For Privacy-Law-Informed Risk Assessment Of Public Social-Media Data, Heba Ismail

All Works

Public social-media content often contains self-disclosed personal attributes that appear low-risk in isolation but become privacy-relevant when linked across posts, platform accounts, or user-level traces. Existing research has advanced privacy-sensitive content detection, de-anonymization analysis, social-media research ethics, and privacy-compliance workflows; however, limited work operationalizes how personal-data disclosures combine structurally and how these structures can be translated into auditable governance actions. This paper proposes SEM-PDPL, a computational, privacy-law-informed risk-assessment framework for modeling public social-media exposure as semantic exposure graphs and mapping graph patterns to controls aligned with the United Arab Emirates Personal Data Protection Law (PDPL) and compatible with GDPR principles. …

The Arc Of Crisis: Geopolitical Shifts In The Horn Of Africa And Beyond, Hamdy A. Hassan

All Works

No abstract provided.

Free, Civil Legal Aid: An Examination Of Client Access To Free, Civil Legal Services In Tennessee, Laura E. Brown

Masters Theses and Doctoral Dissertations

Nonprofit law firms and legal aid societies provide free civil legal assistance to low-income individuals who have a civil, legal need and who qualify for the services. However, the provision of such services is not straightforward nor without challenges and barriers. This research study examined the provision of free, civil legal services to eligible citizens of Tennessee to see if there was a difference in the provision of services depending on if the recipient of services resides in a rural, urban, or suburban area. The study also explored if there was a difference in the number of cases closed and …

Hunger, Famine, And Eating Habits, Robert Dirks

Faculty Publications – Sociology and Anthropology

This paper explores how hunger and famine affect various eating habits, including commensal relations within households, shared attitudes toward eating with unfamiliar people, and typical ways of expressing appetite. Drawing on data collected from 124 societies worldwide, it provides a comparative perspective on the influence of food insecurity and nutritional stress on common, everyday eating habits. Analysis shows that chronic nutritional deficiencies and historical experiences with famine are associated with less inclusive, less amiable mealtime behaviors. Discussion offers explanations for the occasional persistence of such patterns despite ample food supply and considers the impact of nutrition alongside other factors likely …

Quantitative Imaging Of Pyruvate Metabolism In A Patient With Anaplastic Thyroid Cancer, James A Bankson, Joshua S Niedzielski, Collin J Harlan, Yunyun Chen, Christopher M Walker, Philip L Lorenzi, Lin Tan, Vikas Kundra, Matthew E Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B Peterson, Clifton D Fuller, Vlad C Sandulache, Stephen Y Lai

Faculty, Staff and Students Publications

Purpose: Magnetic resonance imaging using hyperpolarized (HP) [1-13C]-pyruvate enables assessment of pyruvate metabolism in vivo and offers new insight into metabolic changes in response to cancer therapy. Widely used semi-quantitative metrics of pyruvate metabolism can be affected by physiological factors that are extrinsic to intracellular metabolism. A validated pharmacokinetic (PK) model for analysis of intracellular pyruvate metabolism is needed to enhance the accuracy of quantitative metrics and clinical translation of metabolic MRI using HP pyruvate.

Methods: A PK model with two physical compartments and two chemical pools was developed to analyze the conversion of labeled pyruvate into lactate in vitro. …

De Novo Complex Genomic Rearrangement Spanning 2q31.1 In A Proband With Congenital Malformations: Genotype-Phenotype Correlation And Development Of A Cgr Detection Pipeline, Katherine Helle, Jesse D Bengtsson, Mira Gandhi, Christopher M Grochowski, Ming Yin Lun, Neha Sudhir, Shalini N Jhangiani, Fritz J Sedlazeck, Seema R Lalani, Neil A Hanchard, Claudia M B Carvalho

Faculty, Staff and Students Publications

The 2q31 region is commonly associated with pathogenic alleles of the HOXD cluster leading to various clinical phenotypes related to skeletal development. We present a proband with tetralogy of Fallot and multiple congenital anomalies. Genomic variant screening including an in-house CGR detection pipeline pairing genome sequencing (GS) structural variant calls with read-depth data revealed a de novo complex genomic rearrangement (CGR) spanning 2.7 Mb across 2q31 characterized by a series of duplications and triplications including the HOXD gene cluster. The genomic structure was assembled by applying combined methodologies including short-read and long-read GS, and optical genome mapping (OGM). This in-house …

Colocalization Of Eqtls With Type 2 Diabetes And Glycemic Traits Using Whole-Genome Sequences In Diverse Populations From The Nhlbi Trans-Omics In Precision Medicine (Topmed) Program, Ningyuan Wang, Daniel A Dicorpo, Yixin Zhang, Erica Kleinbrink, Donna K Arnett, John Barnard, John Blangero, Donald W Bowden, April P Carson, Yii-Der Ida Chen, Mina K Chung, Joanne E Curran, Dawood Darbar, Ravindranath Duggirala, Patrick T Ellinor, Diane Fatkin, Myriam Fornage, Nancy Heard-Costa, Jiang He, Lifang Hou, Sharon L R Kardia, Charles Kooperberg, Ruth J F Loos, David D Mcmanus, Braxton D Mitchell, Ryan L Minster, Kari E North, Bruce M Psaty, Laura M Raffield, Susan Redline, Stephen S Rich, Dan Roden, Jerome I Rotter, Moore B Shoemaker, Jonathan D Smith, David R Van Wagoner, Francois Aguet, Kristin Ardlie, Joshua C Bis, Jennifer A Brody, Brian E Cade, Clary B Clish, Paul S De Vries, James S Floyd, Barry I Freedman, Stacey Gabriel, Robert E Gerzsten, Mark O Goodarzi, Charles Gu, Xiuqing Guo, Namrata Gupta, Susan R Heckbert, Sarah Hsu, Yi-Jen Hung, Rita R Kalyani, Tanika N Kelly, Gregory L Kinney, Changwei Li, Simin Liu, Yongmei Liu, Donald M Lloyd-Jones, Joann E Manson, Rasika A Mathias, Josep M Mercader, Alanna C Morrison, Take Naseri, Suna Onengut, Nicholette D Palmer, Patricia A Peyser, Qibin Qi, Sridharan Raghavan, Alex P Reiner, Mary R Rooney, Magdalena Sevilla-Gonzalez, Chloe Sarnowski, Joshua D Smith, Jennifer A Smith, Nicole L Spartano, Usman Tahir, Kent D Taylor, Deirdre K Tobias, Russel P Tracy, Satupa'itea Viali, Heming Wang, Alexis C Wood, Lisa R Yanek, Wei Zhao, Yinan Zheng, Josée Dupuis, Ching-Ti Liu, Robert Sladek, Jennifer Wessel, James B Meigs, Alisa K Manning, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium

Faculty, Staff and Students Publications

Large-scale multiancestry genome-wide association studies have identified hundreds of loci associated with type 2 diabetes (T2D) and glycemic traits, yet imputed genotyping arrays limit the detection of low-frequency and rare variants. Whole-genome sequencing (WGS) offers a more complete view of genetic variation, especially across diverse populations. We analyzed high-coverage (38×) WGS data from 21,913 T2D case subjects, 61,036 control subjects, and up to 50,011 individuals with no diabetes with fasting glucose, fasting insulin, and HbA1c from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Program. We performed single-variant association testing, conditional analysis, fine-mapping, and Bayesian colocalization to …

Future Prospects Of Pediatric Lung Transplantation, Ernestina Melicoff, David Moreno Mcneill, Christian Benden

Faculty, Staff and Students Publications

This special issue of the Journal of Heart Transplantation Open is dedicated to Pediatric Thoracic Transplantation. The authors will discuss subjects related to pediatric lung transplantation such as access to donor organs, allograft dysfunction and role of functional status in outcomes.

Indications, Techniques, And Safety Of Cryotherapy And Cryobiopsy Via Flexible Bronchoscopy In Pediatric Patients, Alex J Katz, Haley Haskett, Kubra M Bozkanat, Aoife Corcoran, Lauren M C Grant, Antoinette Wannes Daou, Sin Tran, Esra Caylan, Alfin Vicencio, Dan T Benscoter, Cherie A Torres-Silva, Sara M Zak, Gregory Burg, Lisa R Young, Pelton Phinizy, Shailendra Das, Richard Paul Boesch, Erik B Hysinger, Joseph Piccione

Faculty, Staff and Students Publications

Rationale: Cryotherapy and its diagnostic analogue, cryobiopsy, are emerging techniques via bronchoscopy with a wide range of clinical applications. While the use of cryotherapy and cryobiopsy has been established in adult pulmonary medicine, pediatric data describing the indications, procedural specifics, outcomes, and complications are limited.

Objective: To describe the indications, procedural specifics, outcomes, and complications of cryotherapy and cryobiopsy use in pediatric bronchoscopy.

Methods: A multicenter retrospective observational study was conducted at 5 pediatric hospitals in the United States. Patients aged 0 to 21 years who underwent cryotherapy or cryobiopsy via bronchoscopy between January 2017 and January 2025 were included. …

Proteomic Signatures Of 3-Year Progression From Impaired Fasting Glucose To Diabetes: The Atherosclerosis Risk In Communities (Aric) Study, Mary R Rooney, Justin B Echouffo Tcheugui, Jingsha Chen, Keenan A Walker, Christie M Ballantyne, Eric Boerwinkle, Tanika N Kelly, Chiadi E Ndumele, James S Pankow, Morgan E Grams, Wendy S Post, Peter J Ganz, Alexis C Wood, Jerome I Rotter, Elizabeth Selvin, Josef Coresh

Faculty, Staff and Students Publications

Objective: To identify proteomic signatures underlying 3-year progression from impaired fasting glucose (IFG) to diabetes.

Research design and methods: We examined IFG progression in the Atherosclerosis Risk in Communities (ARIC) study from visit 2 (1990-1992) to visit 3 (1993-1995). We tested associations of 4,955 plasma proteins (SomaScan version 4.0) with ∼3-year progression from IFG (FG 100-125 mg/dL without diabetes) to diabetes (diagnosis, medication, or FG ≥126 mg/dL) using logistic regression models adjusted for demographics, cardiometabolic risk factors, and baseline glucose with Bonferroni correction (P < 10-5). We explored biological pathways enriched among the top proteins and calculated improvements in prediction (ΔAUC and net reclassification using 3-year risk thresholds of 6% and 15% in 80% training and 20% internal validation subsamples). We validated results in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.

Results: There were 3,786 ARIC participants with IFG (mean [SD] age 57 [6] years, 52% female, …

Rates Of, Reasons For, And Reactions To Discontinuation Of Glp-1 Receptor Agonists: A Narrative Review, Henry D Heisey, L Parker Gregg, Christopher D Verrico, Dennis T Villareal, Terri L Fletcher

Faculty, Staff and Students Publications

GLP-1RAs are increasingly used for their glucose-lowering and weight-management effects, but many patients discontinue them. In this narrative review we aim to review real-world, quantitative and qualitative GLP-1RA discontinuation, adherence, and persistence evidence as it aligns with an established conceptual framework for understanding medication adherence in noncommunicable chronic disease. Many inconsistencies exist in how discontinuation, adherence, and persistence are studied in this literature. Few qualitative studies have focused on discontinuation of GLP-1RAs. Quantitative approaches often focus on medication-related factors and more superficial aspects of socioeconomic and condition-related factors. Very few studies encompass all 5 dimensions of the medication adherence conceptual …

Nutrition Considerations In Youth With Type 2 Diabetes Using Glucagon-Like Peptide-1 Receptor Agonists: A Commentary, Maria E Diaz, Grace Kim, Mili Vakharia

Faculty, Staff and Students Publications

No abstract provided.

Cost-Effectiveness Of Hes V2.0 And Galad For Hepatocellular Carcinoma Surveillance In Patients With Cirrhosis, Mert Sahinkoc, Gizem S Nemutlu, Hashem B El-Serag, Mary Linton B Peters, Ali Hajjar, Anthony E Samir, Leigh Anne Dageforde, Fasiha Kanwal, Jagpreet Chhatwal

Faculty, Staff and Students Publications

Background: Ultrasound-based surveillance for HCC is limited by suboptimal sensitivity and low adherence. Blood-based biomarkers are potential alternatives for routine HCC surveillance. We aimed to define optimal sensitivity, specificity, and cost parameters under which blood-based biomarkers could serve as cost-effective alternatives in patients with cirrhosis.

Methods: We developed a microsimulation model of the natural history of HCC in individuals with compensated cirrhosis. We compared the cost-effectiveness of biannual surveillance using 2 blood-based biomarkers-HES V2.0 and GALAD-versus ultrasound-based surveillance across a range of sensitivity, specificity, test costs, and adherence levels. Outcomes included quality-adjusted life years (QALYs), costs, and incremental cost-effectiveness ratios …

Clingen Variant Curation Interface Workshops: Training Variant Scientists On An International Platform, Deborah I Ritter, Mark Mandell, Christine Preston, Marina Distefano, Sahia M Bryant, Nadia Carstens, Rolanda S Julius, Aimé Lumaka, Madhuri Hegde, Joanne Ngeow, Joannella Morales, Matt W Wright, Heidi L Rehm, Sharon E Plon

Faculty, Staff and Students Publications

Purpose: The Clinical Genome Resource (ClinGen) is creating a central resource of clinically relevant genetic knowledge to improve genomic medicine. Dissemination and use of the ClinGen Resource is essential to ensure broad community uptake. We report on experiences and sustained use of ClinGen tools through engaging international genetics groups based in India, Africa, and Singapore in variant classification training workshops using the ClinGen Variant Curation Interface (VCI).

Methods: We developed pre- and postworkshop questionnaires and analyzed ClinGen tool use following the workshops. We evaluated organizational aspects and costs of creating a dedicated ClinGen VCI instance for each workshop.

Results: The …

Increased Risk Of Sarcomas In Children With Congenital Anomalies: Findings From The Genetic Overlap Between Anomalies And Cancer In Kids (Goback) Registry Linkage Study, Russ Wolters, Ji Yun Tark, Tiffany M Chambers, Tania A Desrosiers, Michael E Scheurer, Charles Shumate, Wendy N Nembhard, Mahsa M Yazdy, Eirini Nestoridi, Amanda E Janitz, Jean Paul Tanner, Russell S Kirby, Jason L Salemi, Yao Yu, Chad D Huff, Sharon E Plon, Philip J Lupo, Jeremy M Schraw

Faculty, Staff and Students Publications

Background: Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated.

Procedure: We obtained data on maternal and perinatal characteristics, congenital anomalies, and pediatric sarcoma diagnoses for all live births in nine states. We used Cox proportional hazards regression to estimate the hazard ratio (HR) and 95% confidence interval (CI) of sarcoma (overall and by subtype) among children with non-syndromic congenital anomalies. We considered all non-syndromic …

Global Disparities In Neurosurgical Literature: A Narrative Review Of Underrepresentation Of Low- And Middle-Income Countries And Pathways To Research Equity, Tirath Patel, Naveed Ahmad, Abbas Hussain, Bisma Faraz, Amna Binte Naeem, Urooj Sheraz, Laiba Noor, Saleha Khan, Muhammad Seerat Ali, Nikhilesh Anand

School of Medicine Publications

The global neurosurgical literature is dominated by high-income countries, with low- and middle-income countries (LMICs) contributing minimally despite bearing the most significant share of the neurosurgical disease burden. Underrepresentation limits equitable knowledge dissemination and the relevance of guidelines. The objective of this review was to assess neurosurgical publication disparities, identify deterrents to LMIC participation, and outline initiatives that foster equity and inclusion in research. This narrative review synthesized evidence on global disparities in neurosurgical literature through a structured search of PubMed, Scopus, and Google Scholar (2010–2025). Eligible studies examined research output, authorship trends, publication barriers, or equity initiatives. Findings mapped …

Engagement Of Understudied Populations As Community Change: The South Texas Adrc Model, Gladys E. Maestre, Neela K. Patel, Rosa V. Pirela, Robin C. Hilsabeck, Kendra Stine, Neyra García, Roberto Reyes, Omar Oropeza, Cristian Maestre, Jesus D. Melgarejo, Sarah Williams-Blangero, Ney Alliey Rodriguez, Sylvia A. Robles

School of Medicine Publications

Many populations experiencing the highest burdens of Alzheimer's disease and related dementias remain understudied, in part because traditional recruitment and retention models are insufficient to support sustained engagement. The Outreach, Recruitment, and Engagement Core (OREC) of the South Texas Alzheimer's Disease Research Center reconceptualized participant recruitment as a long-term system change in a Hispanic-majority, urban–rural region. OREC institutionalizes shared power through community advisory governance, aligns research protocols with local lived realities (through patient navigators, community health workers/promotores, and decentralized access points), and employs a data-driven feedback loop for continuous improvement. In 1 year, 46 outreach events touched 10,134 individuals (71% …