Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 80041 - 80070 of 1740674

Full-Text Articles in Entire DC Network

Dynamic Postural Stability And Asymmetry In Thigh Circumference And Single-Leg Hop Test Following Anterior Cruciate Ligament Reconstruction, Aguri Kamitani, Derrick M Knapik, Matthew V Smith, John Motley, Sina Tartibi, Amanda Haas, Rick Wright, Matthew J Matava, Robert H Brophy Jul 2025

Dynamic Postural Stability And Asymmetry In Thigh Circumference And Single-Leg Hop Test Following Anterior Cruciate Ligament Reconstruction, Aguri Kamitani, Derrick M Knapik, Matthew V Smith, John Motley, Sina Tartibi, Amanda Haas, Rick Wright, Matthew J Matava, Robert H Brophy

2020-Current year OA Pubs

PURPOSE: To evaluate changes in limb symmetry index (LSI) in thigh circumference and single-leg hop for distance (SLHD) after anterior cruciate ligament reconstruction (ACLR) out to 18 months postoperatively and their association to changes in dynamic postural stability after ACLR out to 24 months.

METHODS: Patients were prospectively enroled after ACLR and followed up at 3-month intervals. Thigh circumference was measured preoperatively out to 18 months postoperatively, dynamic postural stability out to 24 months, and SLHD from 6 to 18 months following ACLR. LSI was calculated from the thigh circumference and SLHD measurements. Dynamic postural stability (DPS) was measured on …


Clinical Assessment On Days 1-14 For The Characterization Of Traumatic Brain Injury: Recommendations From The 2024 Ninds Traumatic Brain Injury Classification And Nomenclature Initiative Clinical/Symptoms Working Group, Thomas J Bayuk, Shubhayu Bhattacharyay, David L Brody, Scott A Cota, Ari Ercole, Anthony Figaji, Guoyi Gao, Christopher C Giza, Fiona Lecky, Rebekah Mannix, Ana Mikolić, Kasey E Moritz, Claudia S Robertson, Abel Torres-Espin, Spyridoula Tsetsou, John K Yue, Hibah O Awad, Kristen Dams-O'Connor, Adele Doperalski, Andrew I R Maas, Michael A Mccrea, Nsini Umoh, Geoffrey T Manley Jul 2025

Clinical Assessment On Days 1-14 For The Characterization Of Traumatic Brain Injury: Recommendations From The 2024 Ninds Traumatic Brain Injury Classification And Nomenclature Initiative Clinical/Symptoms Working Group, Thomas J Bayuk, Shubhayu Bhattacharyay, David L Brody, Scott A Cota, Ari Ercole, Anthony Figaji, Guoyi Gao, Christopher C Giza, Fiona Lecky, Rebekah Mannix, Ana Mikolić, Kasey E Moritz, Claudia S Robertson, Abel Torres-Espin, Spyridoula Tsetsou, John K Yue, Hibah O Awad, Kristen Dams-O'Connor, Adele Doperalski, Andrew I R Maas, Michael A Mccrea, Nsini Umoh, Geoffrey T Manley

Faculty, Staff and Students Publications

The current classification of traumatic brain injury (TBI) primarily uses the Glasgow Coma Scale (GCS) to categorize injuries as mild (GCS 13-15), moderate (GCS 9-12), or severe (GCS ≤8). However, this system is unsatisfactory, as it overlooks variations in injury severity, clinical needs, and prognosis. A recent report by the National Academies of Sciences, Engineering, and Medicine (USA) recommended updating the classification system, leading to a workshop in 2024 by the National Institute of Neurological Disorders and Stroke. This resulted in the development of a new clinical, biomarker, imaging, and modifier (CBI-M) framework, with input from six working groups, including …


Definition And Classification Of Dystonia, Mark Hallett, Joseph Jankovic, Christine Klein, Joachim K Krauss, Anthony E Lang, Jonathan W Mink, Sanjay Pandey, Jan K Teller, Marina A J Tijssen, Marie Vidailhet, H A Jinnah Jul 2025

Definition And Classification Of Dystonia, Mark Hallett, Joseph Jankovic, Christine Klein, Joachim K Krauss, Anthony E Lang, Jonathan W Mink, Sanjay Pandey, Jan K Teller, Marina A J Tijssen, Marie Vidailhet, H A Jinnah

Faculty, Staff and Students Publications

Dystonia is a movement disorder with varied clinical features and diverse etiologies. Here we present a revision of the 2013 consensus definition and classification of dystonia in light of subsequent publications and experience with its application during the last decade. A panel of movement disorder specialists with expertise in dystonia reviewed the original document and proposed some revision. There was broad consensus to retain the definition of dystonia with only minor clarifications to the wording. Dystonia is defined as a movement disorder characterized by sustained or intermittent abnormal movements, postures, or both. Dystonic movements and postures are typically patterned and …


Predictors Of Failure To Rescue After Fenestrated-Branched Endovascular Aortic Repair Of Thoracoabdominal Aortic Aneurysms: Presented At The Thirty-Seventh Annual Meeting Of The European Society Of Vascular Surgery, Belfast, Northern Ireland, September 26-29, 2023, Bernardo C Mendes, Tomasz Jakimowicz, Darren B Schneider, Stéphan Haulon, Jonathan Sobocinski, Adam W Beck, Andres Schanzer, Mark A Farber, Carlos Timaran, Andrea Kahlberg, Tilo Kölbel, Warren J Gasper, Barend M E Mees, Mauro Gargiulo, Nuno V Dias, Anthony Lee Woongchae, Matthew P Sweet, Kevin Mani, Matthew Eagleton, Luis Mendes Pedro, Hence Verhagen, Kak Khee Yeung, Nikolaos Tsilimparis, Timothy Resch, Luca Bertoglio, Emília Ferreira, Manar Khashram, Titia Sulzer, Marina Dias-Neto, Emanuel R Tenorio, Lucas Ruiter Kanamori, Katarzyna Jama, Ezequiel Parodi, Vivian Gomes, Jesus Porras Colon, Roberto Chiesa, Giuseppe Panuccio, Geert Willem Schurink, Charlotte Lemmens, Enrico Gallitto, Gianluca Faggioli, Angelos Karelis, Anders Wanhainen, Mohammed Habib, Ryan Gouveia E Melo, Kaj Olav Kappe, Samira Elize Mariko Van Knippenberg, Bichlan Tran, Sean Crawford, Marco Panagrosso, Andrea Melloni, Stefano Bonardelli, Rita Garcia, Tiago Ribeiro, Sinead Gormley, Steven Maximus, Gustavo S Oderich, International Multicenter Aortic Research Group Jul 2025

Predictors Of Failure To Rescue After Fenestrated-Branched Endovascular Aortic Repair Of Thoracoabdominal Aortic Aneurysms: Presented At The Thirty-Seventh Annual Meeting Of The European Society Of Vascular Surgery, Belfast, Northern Ireland, September 26-29, 2023, Bernardo C Mendes, Tomasz Jakimowicz, Darren B Schneider, Stéphan Haulon, Jonathan Sobocinski, Adam W Beck, Andres Schanzer, Mark A Farber, Carlos Timaran, Andrea Kahlberg, Tilo Kölbel, Warren J Gasper, Barend M E Mees, Mauro Gargiulo, Nuno V Dias, Anthony Lee Woongchae, Matthew P Sweet, Kevin Mani, Matthew Eagleton, Luis Mendes Pedro, Hence Verhagen, Kak Khee Yeung, Nikolaos Tsilimparis, Timothy Resch, Luca Bertoglio, Emília Ferreira, Manar Khashram, Titia Sulzer, Marina Dias-Neto, Emanuel R Tenorio, Lucas Ruiter Kanamori, Katarzyna Jama, Ezequiel Parodi, Vivian Gomes, Jesus Porras Colon, Roberto Chiesa, Giuseppe Panuccio, Geert Willem Schurink, Charlotte Lemmens, Enrico Gallitto, Gianluca Faggioli, Angelos Karelis, Anders Wanhainen, Mohammed Habib, Ryan Gouveia E Melo, Kaj Olav Kappe, Samira Elize Mariko Van Knippenberg, Bichlan Tran, Sean Crawford, Marco Panagrosso, Andrea Melloni, Stefano Bonardelli, Rita Garcia, Tiago Ribeiro, Sinead Gormley, Steven Maximus, Gustavo S Oderich, International Multicenter Aortic Research Group

Faculty, Staff and Students Publications

No abstract provided.


Value-Added Utilization Of Agricultural Wastes In Biocomposite Production: Characteristics And Applications, Nadir Ayrilmis, Ehab El Sayed Massoud, Murugesan Palaniappan, S Lakshmi Sankar Jul 2025

Value-Added Utilization Of Agricultural Wastes In Biocomposite Production: Characteristics And Applications, Nadir Ayrilmis, Ehab El Sayed Massoud, Murugesan Palaniappan, S Lakshmi Sankar

Faculty, Staff and Students Publications

Agro-waste-based biocomposites are reinforced with natural fibers derived from agricultural residues. These biocomposite materials have attracted a great deal of interest in recent years due to their environmentally friendly and sustainable nature as an alternative to conventional synthetic materials. Issues of environmental sustainability and the search for waste management solutions have driven research into the development of materials that minimize reliance on nonrenewable resources and have a low environmental impact. This review presents an overview of the physical and mechanical properties of some selected biocomposites derived from rice husk, coconut shell, and sugarcane bagasse. Critical properties such as density, water …


A Survey Study Of Roadblocks In Translational Science, Claudia Neuhauser, Ariel Harrison, Mary E Dickinson, Charles Minard, Bettina M Beech Jul 2025

A Survey Study Of Roadblocks In Translational Science, Claudia Neuhauser, Ariel Harrison, Mary E Dickinson, Charles Minard, Bettina M Beech

Faculty, Staff and Students Publications

Clinical and translational science needs to address roadblocks to the translational processes. We conducted a survey at two institutions, a private medical school and a large public university, to understand the frequency and distribution of barriers and roadblocks to research. We reviewed the literature to compile a pool of barriers and roadblocks and convened a panel of relevant stakeholders to develop a 20-item questionnaire. Survey respondents were asked to select and prioritize the five leading clinical and translational roadblocks, provide information regarding their academic degrees and rank/position, complete open-ended items regarding their areas of research, and optionally add additional remarks …


In Reply: Most Elderly Patients With Subclinical Hypothyroidism Do Not Need To Be Treated, Kristina Little Jul 2025

In Reply: Most Elderly Patients With Subclinical Hypothyroidism Do Not Need To Be Treated, Kristina Little

Faculty, Staff and Students Publications

No abstract provided.


Does External Labour Market Activeness Affect Agency Problem?, Yuyun Claudie Huang, Jamie Yixing Tong, Joey W. Yang Jul 2025

Does External Labour Market Activeness Affect Agency Problem?, Yuyun Claudie Huang, Jamie Yixing Tong, Joey W. Yang

Research outputs 2022 to 2026

This study examines the relationship between external labour market and the agency problem. Exploiting the staggered recognition of the Inevitable Disclosure Doctrine (IDD) by US state courts to capture a drop in external labour market activeness, we examine whether and how the activeness of external labour market affects managers' empire building behaviour. We find that in IDD-recognising states, managers are less engaged in empire-building activity, thus reducing agency costs and improving firm performance. The effect is concentrated in managers with heightened career concern where their firms experience higher degrees of financial constraints or operate within an industry of more intense …


Manufactured Superiority: The War On Terror, United States Dominated Media, And The Global Implications Of American Exceptionalism, Ayan Mohamed Jul 2025

Manufactured Superiority: The War On Terror, United States Dominated Media, And The Global Implications Of American Exceptionalism, Ayan Mohamed

Undergraduate Theses and Capstone Projects

This research examines American exceptionalism and its effects on the global perception of the United States, specifically how it shapes international narratives, marginalizes alternative perspectives, and reinforces a ruling American worldview that inhibits effective engagement and cross-cultural dialogue. The study will focus on two key areas: U.S. military interventions and media representation. First, it will analyze the War on Terror in Afghanistan and Iraq (2001–2021), assessing how U.S.-enforced destabilization in the region perpetuates hegemonic control. Second, it will investigate U.S.-backed, Israel-led Palestinian erasure as a case study of interventionism that positions the U.S. as the self-designated enforcer of global order. …


The Experience Of Codependency In Young Adult Romantic Relationships, Amanda S. Soares Jul 2025

The Experience Of Codependency In Young Adult Romantic Relationships, Amanda S. Soares

Undergraduate Theses and Capstone Projects

This qualitative study used Interpretative Phenomenological Analysis (IPA) to explore the lived experiences of codependency among four young adults (ages 21–24) who had recently exited a codependent romantic relationship. Through in-depth interviews, themes around emotional enmeshment, identity loss, boundary erosion, emotional suppression, and healing were found. Findings indicate that early attachment patterns, trauma, and socialization intersect with emotional vulnerability and self-worth to create conditions ripe for codependent dynamics. Participants describe both the psychological toll of these relationships and the personal growth that followed. These insights contribute to the limited literature on young adult codependency and may inform prevention and intervention …


Placental Metabolism Is Linked To Prenatal Vitamin Supplement Use In The First Month Of Pregnancy In The Marbles Cohort, Meghan Miller, Irva Hertz-Picciotto, Cheryl K Walker, Carolyn M Slupsky Jul 2025

Placental Metabolism Is Linked To Prenatal Vitamin Supplement Use In The First Month Of Pregnancy In The Marbles Cohort, Meghan Miller, Irva Hertz-Picciotto, Cheryl K Walker, Carolyn M Slupsky

Faculty, Staff and Students Publications

Background: The first month of pregnancy is a key time in early developmental programming. Prenatal vitamin/mineral supplement use during the first month of pregnancy (PNVmo1) was associated with reduced risk of autism spectrum disorder (ASD) in the Markers of Autism Risk in Babies, Learning Early Signs (MARBLES) cohort.

Objectives: We aimed to evaluate the associations between PNVmo1, the placental and umbilical cord serum metabolomes, and the child's later neurodevelopmental outcome in the MARBLES pregnancy cohort.

Methods: Placental (n = 78) and umbilical cord serum (n = 132) metabolomes were investigated using 1H nuclear magnetic resonance spectroscopy. PNVmo1 was determined by …


Mass Spectrometry Imaging Reveals Alterations In Protein And N-Glycan Molecular Signatures In Endometriosis Tissues, Christina Salazar, Michael T Breen, Livia S Eberlin Jul 2025

Mass Spectrometry Imaging Reveals Alterations In Protein And N-Glycan Molecular Signatures In Endometriosis Tissues, Christina Salazar, Michael T Breen, Livia S Eberlin

Faculty, Staff and Students Publications

Endometriosis is a gynecological condition characterized by the uncontrolled growth of endometrial-like tissue outside the uterine cavity. Although highly prevalent, the biological mechanisms of endometriosis are poorly understood, and the disease is often misdiagnosed due to the unavailability of pre-operative diagnostic methods. Thus, better characterization of molecular markers of endometriosis are critical to improve our understanding of the disease and management of patients. Here, we used matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) imaging to investigate protein and N-glycan molecular signatures in eutopic endometrium and endometriosis lesions from tissues prospectively collected from patients. MALDI MS imaging of intact proteins …


Integrative Analysis Reveals The Prognostic Effects Of Epigenetic Regulators In Bladder Cancer, Naail Chowdhury, Jianrong Li, Chao Cheng Jul 2025

Integrative Analysis Reveals The Prognostic Effects Of Epigenetic Regulators In Bladder Cancer, Naail Chowdhury, Jianrong Li, Chao Cheng

Faculty, Staff and Students Publications

Background: Epigenetic regulatory genes (epiRG) are pivotal in the epigenetic regulation of the human genome, primarily through DNA and histone modifications. These genes are frequently mutated in human cancers, particularly bladder cancer (BC). However, the functional impact of epiRG mutations on patient outcomes remains poorly understood.

Methods: In this study, we developed gene signatures for the most frequent genomic aberrations of epiRG using The Cancer Genome Atlas Bladder Carcinoma (TCGA-BLCA) dataset and validated these signatures with independent tumor expression profiles for prognostic relevance. Furthermore, we evaluated the role of these signature scores in the immune system within the tumor microenvironment …


Immediate Skin-To-Skin Contact And Postpartum Hemorrhagic Morbidity, Minhazur R Sarker, Hector Mendez-Figueroa, Suneet Chauhan Jul 2025

Immediate Skin-To-Skin Contact And Postpartum Hemorrhagic Morbidity, Minhazur R Sarker, Hector Mendez-Figueroa, Suneet Chauhan

Faculty, Staff and Students Publications

Objective: To examine rates of postpartum hemorrhagic (PPH) morbidity among patients who did and did not have immediate skin-to-skin contact (SSC).

Methods: This study was a retrospective cohort of all non-anomalous, term singleton vaginal births at a Level IV center over 2 years. Exclusion criteria included COVID-19. Immediate SSC was defined as at least 60 min of direct contact initiated between parturient and neonate within 10 min of birth. The primary outcome was a composite of maternal morbidity related to PPH compared among those with and without immediate SSC. We used multivariable Poisson regression adjusted for possible confounders with robust …


Real-World Continuous Smartwatch-Based User Authentication, N. Al-Naffakh, N. Clarke, F. Li, P. Haskell-Dowland Jul 2025

Real-World Continuous Smartwatch-Based User Authentication, N. Al-Naffakh, N. Clarke, F. Li, P. Haskell-Dowland

School of Engineering, Computing and Mathematics

User authentication is often regarded as the “gatekeeper” of cyber security. It has, however, long suffered from significant usability issues that have resulted in research focussing upon frictionless and transparent biometric approaches. Activity-based user authentication—a technique that authenticates a user by what they are physically doing at a specific point in time has attracted significant attention, particularly due to the increasing popularity of smartwatches. This research aims to overcome limitations in prior work by exploring the viability of the approach in real-world conditions. The study presents two principal experiments, one focused upon a constrained environment to provide a control and …


Reduced Risk Of Cesarean Delivery With Oxytocin Discontinuation In Active Labor: A Systematic Review And Meta-Analysis, Julia Whitley, Julia Burd, Michelle Doering, Jeannie Kelly, Antonina Frolova, Nandini Raghuraman Jul 2025

Reduced Risk Of Cesarean Delivery With Oxytocin Discontinuation In Active Labor: A Systematic Review And Meta-Analysis, Julia Whitley, Julia Burd, Michelle Doering, Jeannie Kelly, Antonina Frolova, Nandini Raghuraman

2020-Current year OA Pubs

OBJECTIVE: Our objective was to determine if oxytocin discontinuation in the active phase of labor impacts the rate of cesarean delivery compared to continuation of oxytocin.

DATA SOURCES: This study was a systematic review and meta-analysis of randomized controlled trials. A research librarian performed a database search using a combination of standardized terms and keywords related to oxytocin discontinuation and stages of labor from database inception until February 2024. This protocol was registered in The International Prospective Register of Systematic Reviews (PROSPERO).

STUDY ELIGIBILITY CRITERIA: Randomized controlled trials of pregnant patients who received oxytocin for induction or augmentation of labor, …


Liger-Hn Phase Iii Trials Of Petosemtamab + Pembrolizumab And Petosemtamab Monotherapy In Recurrent Or Metastatic Hnscc, Jean-Pascal Machiels, Douglas Adkins, Et Al. Jul 2025

Liger-Hn Phase Iii Trials Of Petosemtamab + Pembrolizumab And Petosemtamab Monotherapy In Recurrent Or Metastatic Hnscc, Jean-Pascal Machiels, Douglas Adkins, Et Al.

2020-Current year OA Pubs

Patients with recurrent/metastatic (r/m) head and neck squamous cell carcinoma (HNSCC) have limited treatment options and a dismal prognosis, especially when their cancer is resistant to standard treatments like anti-programmed cell death protein 1 and platinum-based therapies. Petosemtamab - a human, common light chain, bispecific antibody with enhanced antibody-dependent cellular cytotoxicity targeting epidermal growth factor receptor (EGFR) and leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) - demonstrated antitumor activity in r/m HNSCC. In many tumor types, including HNSCC, EGFR is an oncogenic driver, while LGR5 is upregulated. LGR5 can potentiate the wingless-type integration site (WNT)/β-catenin signaling pathway in response to …


Where Should The Cancer Control Interventions Target: A Geospatial Hotspot Analysis For Major Cancer Mortality 2018 To 2022 In The United States, Chongliang Luo, Saira Khan, Liyan Jin, Aimee S James, Graham A Colditz, Bettina F Drake Jul 2025

Where Should The Cancer Control Interventions Target: A Geospatial Hotspot Analysis For Major Cancer Mortality 2018 To 2022 In The United States, Chongliang Luo, Saira Khan, Liyan Jin, Aimee S James, Graham A Colditz, Bettina F Drake

2020-Current year OA Pubs

BACKGROUND: Identifying changes in geographic disparities of cancer mortality reveals locations where cancer prevention and control efforts should be focused/targeted. We use recent cancer surveillance data to demonstrate the geographic disparity of major cancer mortality rates in the United States and its shift compared with previous data.

METHODS: This cross-sectional study used the 2018 to 2022 county-level mortality rates of colorectal, lung, breast, and prostate cancers from the Centers for Disease Control mortality data. Counties with suppressed death counts were imputed by spatial regression models. Getis-Ord Gi* statistics were used to evaluate the spatial clustering of county mortality. Identified hotspot …


Phospho-Rpa2 Predicts Response To Platinum And Parp Inhibitors In Homologous Recombination-Proficient Ovarian Cancer, Angela Schab, Amanda Compadre, Rebecca Drexler, Megan Loeb, Kevin Rodriguez, Joshua Brill, Carmen Sandoval, Brooke Sanders, Lindsay Kuroki, Carolyn Mccourt, Andrea R. Hagemann, Premal Thaker, David Mutch, Matthew Powell, Ian S. Hagemann, Lulu Sun, Priyanka Verma, Elena Lomonosova, Dineo Khabele, Mary M. Mullen, Et Al. Jul 2025

Phospho-Rpa2 Predicts Response To Platinum And Parp Inhibitors In Homologous Recombination-Proficient Ovarian Cancer, Angela Schab, Amanda Compadre, Rebecca Drexler, Megan Loeb, Kevin Rodriguez, Joshua Brill, Carmen Sandoval, Brooke Sanders, Lindsay Kuroki, Carolyn Mccourt, Andrea R. Hagemann, Premal Thaker, David Mutch, Matthew Powell, Ian S. Hagemann, Lulu Sun, Priyanka Verma, Elena Lomonosova, Dineo Khabele, Mary M. Mullen, Et Al.

2020-Current year OA Pubs

BACKGROUNDTreatment of tubo-ovarian high-grade serous carcinoma (HGSC) includes cytoreductive surgery, platinum-based chemotherapy, and often poly(ADP-ribose) polymerase (PARP) inhibitors. While homologous recombination (HR) deficiency is a well-established predictor of therapy sensitivity, over 50% of HR-proficient HGSCs also exhibit sensitivity. Currently, there are no biomarkers to identify which HR-proficient HGSCs will be sensitive to standard-of-care therapy. Replication stress may serve as a key determinant of response.METHODSWe evaluated phospho-RPA2-T21 (p-RPA2) foci via immunofluorescence as a biomarker of replication stress in formalin-fixed, paraffin-embedded HGSC samples collected at diagnosis from patients treated with platinum chemotherapy (discovery cohort, n = 31; validation cohort, n = 244) …


Reference Range Determination For The Sflt-1/Plgf Ratio In A Diverse Cohort Of Pregnant Women In The United States, Antonio F Saad, David M Haas, Eugene Chang, Scott A Shainker, Miriah Denbo, Michelle Silasi, George Saade, Sarosh Rana, Tetsuya Kawakita, Luis D Pacheco, Jennifer Powers Carson, Angela Dietl, Deirdre Allegranza, Ge Guo, David Stamilio Jul 2025

Reference Range Determination For The Sflt-1/Plgf Ratio In A Diverse Cohort Of Pregnant Women In The United States, Antonio F Saad, David M Haas, Eugene Chang, Scott A Shainker, Miriah Denbo, Michelle Silasi, George Saade, Sarosh Rana, Tetsuya Kawakita, Luis D Pacheco, Jennifer Powers Carson, Angela Dietl, Deirdre Allegranza, Ge Guo, David Stamilio

2020-Current year OA Pubs

BACKGROUND: The serum soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio is an established tool for predicting preeclampsia in many countries but is not widely adopted in the United States. This study aimed to determine reference ranges for the Elecsys® sFlt-1/PlGF ratio and the sFlt-1 and PlGF immunoassays (Roche Diagnostics International Ltd) in a diverse US population of healthy pregnant women.

METHODS: This was a prospective, noninterventional sample and data collection study performed between November 2022 and November 2023 at 9 collection sites and one measurement site in the United States. Evaluable women were ≥18 years old, …


Inhibition Of The Gsk3Β/Nav16 Complex Suppresses Early-Stage Alzheimer’S Hyperexcitability, Nolan Michael Dvorak, Aditya Kumar Singh, Nana Aboadwe Goode, Jully Singh, Berenice Gutierrez Grebenkova, Mate Marosi, Jessica Di Re, Leandra Koff, Wissarut Wijitrmektong, Manu Bala, Hanyue Liao, Marijn Lijffijt, Adam Thomas Szafran, Michael James Bolt, Michael A Mancini, Gregory D Cuny, Diana Shu-Lian Chow, Agenor Limon, Jeannie Chin, Fernanda Laezza Jul 2025

Inhibition Of The Gsk3Β/Nav16 Complex Suppresses Early-Stage Alzheimer’S Hyperexcitability, Nolan Michael Dvorak, Aditya Kumar Singh, Nana Aboadwe Goode, Jully Singh, Berenice Gutierrez Grebenkova, Mate Marosi, Jessica Di Re, Leandra Koff, Wissarut Wijitrmektong, Manu Bala, Hanyue Liao, Marijn Lijffijt, Adam Thomas Szafran, Michael James Bolt, Michael A Mancini, Gregory D Cuny, Diana Shu-Lian Chow, Agenor Limon, Jeannie Chin, Fernanda Laezza

Faculty, Staff and Students Publications

Introduction: Network hyperexcitability (NH) is observed in patients with early-stage Alzheimer's disease (AD), emerging decades before cognitive decline. A key molecular determinant of NH is voltage-gated Na+ channel 1.6 (Nav1.6), which mediates action potential firing in CA1 hippocampal neurons. Ameliorating NH through inhibition of the glycogen-synthase kinase 3β (GSK3β/Nav1.6 complex may provide immediate benefits to cognition and memory and slow AD progression.

Methods: Hight-throughput virtual screening and multiple in vitro biological assays were utilized to identify compound 1063. Patch-clamp electrophysiology and electroencephalogram recordings were utilized to functionally assess 1063 in models of AD neuropathology.

Results: Building on previous studies identifying …


The Effect Of An Interdisciplinary Project On Students’ Understandings Of Mathematical Interdisciplinarity: A Qualitative Action Research Study, Jaime Krause Jul 2025

The Effect Of An Interdisciplinary Project On Students’ Understandings Of Mathematical Interdisciplinarity: A Qualitative Action Research Study, Jaime Krause

Theses and Dissertations

The siloed nature of education has likely caused some high school students to not recognize the interdisciplinary nature of mathematics, leading them to misunderstand its relationship to other subject areas. A misunderstanding of mathematical interdisciplinarity can cause issues when these students approach interdisciplinary problems later in life. The purpose of this study was to observe, investigate, and analyze the ways in which students understand mathematical interdisciplinarity following a collaborative and interdisciplinary project. I implemented a descriptive qualitative action research approach to determine how a collaborative interdisciplinary project on NASA technology in a high school mathematics course affects students’ understandings of …


Examining Coping, Individual Resilience, And Family Resilience As Strengths-Based Factors For Lgbtq+ Individuals, Elizabeth Moriarty Combs Jul 2025

Examining Coping, Individual Resilience, And Family Resilience As Strengths-Based Factors For Lgbtq+ Individuals, Elizabeth Moriarty Combs

Theses and Dissertations

Lesbian, Gay, Bisexual, Transgender, Queer/Questioning, and More (LGBTQ+) individuals are part of a diverse and complex community that has unique considerations regarding physical and mental health. While there is ongoing health equity research regarding LGBTQ+ individuals, the focus is often on health disparities. A strengths-based approach to helping LGBTQ+ individuals through research and other avenues may be beneficial. This multi-manuscript dissertation includes two studies that explored the current literature on strengths-based factors such as coping, individual resilience, and family resilience within LGBTQ+ individuals, as well as determined the feasibility of utilizing these factors to assist LGBTQ+ individuals with health and …


An Investigation Of Preservice And Novice Elementary Education Graduate Students’ Self-Efficacy Toward Teaching Engineering Design, Victoria Harkins Cameron Jul 2025

An Investigation Of Preservice And Novice Elementary Education Graduate Students’ Self-Efficacy Toward Teaching Engineering Design, Victoria Harkins Cameron

Theses and Dissertations

This mixed-methods action research study examined how an experiential learning–based pedagogical approach influenced the development of teaching engineering self-efficacy in preservice and novice elementary education graduate students. Grounded in Bandura’s self-efficacy theory and Kolb’s experiential learning cycle, the study examined the impact of mastery experiences, vicarious experiences, verbal persuasion, and affective states on shaping participants’ instructional self-efficacy. Data were collected using the Teaching Engineering Self-Efficacy Scale (TESS), written reflections, and a focus group. Engineering pedagogical content knowledge was the only TESS construct to show statistically significant gains, while qualitative findings indicated broader growth in self-efficacy and emotional readiness. The study’s …


The Digital Forum: A Pedagogical Approach To Teaching College English Composition, Thomas Edward Plichta Jul 2025

The Digital Forum: A Pedagogical Approach To Teaching College English Composition, Thomas Edward Plichta

Theses and Dissertations

This action research study focused on the identification of ways to improve the curriculum of freshman Writing Intensive Seminars using an innovative multimodal pedagogical methodology, the Digital Forum, in addition to formal papers and in-class writing. The research examined a Writing Intensive Seminar with approximately 20 students; There were two Research Questions for the present study. RQ1: How does the incorporation of the Digital Forum as a pedagogical approach in college freshman writing classes influence students' levels of behavioral, cognitive, and emotional engagement? RQ2: How does the incorporation of Digital Forums in freshman English Composition courses affect the quality of …


Impact Of Participation In Extracurricular Activities On Female Students’ Motivation, Noha Ibrahim Jul 2025

Impact Of Participation In Extracurricular Activities On Female Students’ Motivation, Noha Ibrahim

Theses and Dissertations

This study investigated the impact of extracurricular activities (ECAs) on academic motivation among female high school students at a semi-governmental international school in the UAE. It addressed three research questions: (1) the effect of ECA participation on academic motivation, (2) students’ perceptions of how these activities influence their motivation, and (3) teachers’ perspectives on their impact. I conducted this action research in a school of 4,500 K-12 students predominantly local and from high-income backgrounds with an international teaching staff. Participants included grade 11 and 12 female students (ages 16–18) enrolled in one of four clubs (Reading, International, Sports, and Art) …


Structure-Activity Relationships Of Isothiourea And Silicon Phthalocyanine Catalysts, Christian J. Harrison Jul 2025

Structure-Activity Relationships Of Isothiourea And Silicon Phthalocyanine Catalysts, Christian J. Harrison

Theses and Dissertations

Efficient organic synthesis often relies on improving catalyst designs and investigating reaction mechanisms to accomplish feats such as high stereoselectivity, low catalyst loadings, and performing sustainable chemistry. Within the field of organocatalysis, intermolecular interactions between a catalyst and a substrate are a large contributing factor to the control of a reaction, including rate and selectivity. Investigating mechanisms can provide information on the type of intermolecular interactions occurring in the reaction, aiding future reaction and catalyst development. This dissertation will explore two recent projects and how probing intermolecular interactions through simple modifications provides information useful for new catalyst designs and properties. …


Naqbu: Cosmological Undercurrents In Sumer And Akkad, Fiona Eirene Andrews Jul 2025

Naqbu: Cosmological Undercurrents In Sumer And Akkad, Fiona Eirene Andrews

Theses and Dissertations

The concepts of primordial incomprehensibility, ordered creation, and the liminal chaos between them, form a foundational framework in Mesopotamian intellectual culture. The distinctive ways in which these concepts manifest in Sumero-Akkadian cultures suggest a systematic cosmological substructure — characterized by the paradoxical, cyclical, and co-creative relationships between forces such as Infinity and measure, generation and destruction, and definition and obscurity — that remains insufficiently examined in current scholarship. Drawing from diverse corpus of Mesopotamian creative works, Kabbalistic exegesis, and post-modern scholarship, this thesis seeks to elucidate the essential dynamics within that substructure. By proposing a semiotic hermeneutical strategy attuned to …


Camp In The Kitchen: Feminism And Craft In Liza Lou's Beaded Worlds, Aurora X. Bell Jul 2025

Camp In The Kitchen: Feminism And Craft In Liza Lou's Beaded Worlds, Aurora X. Bell

Theses and Dissertations

Kitchen (1991–96) was the first major work of art by American artist Liza Lou. It is an installation of a life-size kitchen in which every surface and object is covered in glass beads. Kitchen, which Lou refers to as a monument to women’s unsung domestic labor, received considerable critical attention and drew the artist into ongoing conversations around the relationship between “fine art” and “craft” and about the role of feminism in the art of the 1990s. In contemporary interviews, however, Lou expressed discomfort with the label of “craft” as well as with feminist art that she considered “didactic.” …


In Their Own Words: How Standardization Shapes Student Learning Experiences, Jessica Cantley Jul 2025

In Their Own Words: How Standardization Shapes Student Learning Experiences, Jessica Cantley

Theses and Dissertations

This qualitative action research study explores how students perceive and experience standardized and elective educational environments in a rural, Title I high school in the U.S. South. Through semi-structured interviews and focus group discussions with seven diverse participants, the study investigates student-defined learning objectives, motivation and engagement across different classes, and youth perceptions of valuable learning experiences. The research is grounded in constructivism, applying feminist theory and critical race theory as lenses to challenge power dynamics and promote equality in education.

Findings confirm the problem of practice that inspired the study by revealing a contrast between students’ experiences in standardized …