Digital Commons Network^™

From Palimpsest To Prompt: Rewriting Shakespeare, Creative Authorship, And The Generative Logics Of Large Language Models In Contemporary Theatre, Michael Harding, James Hutson

Faculty Scholarship

This article examines the convergence of creative authorship, adaptation, and generative artificial intelligence within contemporary theatre, taking Michael Harding‘s Awake, Young King as a central case study. Through the rewriting of Shakespearean drama, Harding‘s creative process demonstrates how theatrical meaning emerges through ongoing negotiation among playwright, performer, and audience, with scripts historically subject to revision, improvisation, and reinterpretation. Concerns regarding copyright, intellectual property, and the role of AI in the performing arts are reframed as extensions of enduring debates over originality and authorship, rather than novel threats. Tracing the evolution from The Rise of James VI to Awake, Young King, …

Functional Assays In Drosophila Facilitate Classification Of Variants Of Uncertain Significance Associated With Rare Diseases, Jung-Wan Mok, Shelley B Gibson, Haley A Dostalik, Shinya Yamamoto

Faculty, Staff and Students Publications

Individuals living with rare diseases often undergo a frustrating and expensive diagnostic odyssey. Clinical geneticists who analyze exome or genome sequencing data from rare disease patients often encounter a list of variants of uncertain significance (VUS) in known disease-causing genes or rare variants in genes of uncertain significance (GUS) that are difficult to interpret, even with the integration of the latest bioinformatic tools. In this Perspective, we review how studies using the fruit fly Drosophila melanogaster have facilitated rare disease diagnosis by uncovering the clinical relevance of GUS and classifying rare variants into specific allelic categories (loss-of-function or gain-of-function, Muller's …

Performance Comparison Of Quantum And Classical Machine Learning Models For Chronic Kidney Disease Prediction, Parama Sridevi, Paramita Basak Upama, Masud Rabbani, Sheikh Iqbal Ahamed

Computer Science Faculty Research and Publications

In this study, we develop and compare quantum and classical machine learning-based chronic kidney disease prediction models. We used the "Chronic_Kidney_Disease Data Set" of the UCI Machine Learning Repository. We performed data preprocessing and applied feature engineering techniques to select the best features. We developed two quantum machine learning-based models and two classical machine learning-based models. We used a hybrid classical-quantum environment for building quantum machine learning models. Finally, we compared the performances of all four models. We found that the Quantum Support Vector Machine performs best among the quantum models. The model’s accuracy was 95% with a k-fold cross-validation …

Fgf21 Promotes Longevity In Diet-Induced Obesity Through Metabolic Benefits Independent Of Growth Suppression, Christy M Gliniak, Ruth Gordillo, Yun-Hee Youm, Qian Lin, Clair Crewe, Zhuzhen Zhang, Bianca C Field, Teppei Fujikawa, Megan Virostek, Shangang Zhao, Yi Zhu, Clifford J Rosen, Tamas L Horvath, Vishwa Deep Dixit, Philipp E Scherer

Faculty, Staff and Students Publications

Approximately 35% of US adults over 65 are obese, highlighting the need for therapies targeting age-related metabolic issues. Fibroblast growth factor 21 (FGF21), a hormone mainly produced by the liver, improves metabolism and extends lifespan. To explore its effects without developmental confounders, we generated mice with adipocyte-specific FGF21 overexpression beginning in adulthood. When fed a high-fat diet, these mice lived up to 3.3 years, resisted weight gain, improved insulin sensitivity, and showed reduced liver steatosis. Aged transgenic mice also displayed lower levels of inflammatory immune cells and lipotoxic ceramides in visceral adipose tissue, benefits that occurred even in the absence …

Exploring The Efficacy Of Various Minimally Invasive Surgery (Mis) Techniques In Spinal Fusion For Degenerative Spondylolisthesis: A Systematic Review, Yolanda V. Gutierrez, Blake Martin, Joshua Nwose, Alyssa A. Sepulveda, Ronald Shaju, Aamir Ahmad, Robert H. Ablove

School of Medicine Publications

Degenerative spondylolisthesis is a common etiology of low back pain characterized by the anterior displacement of one vertebral body relative to the one below it. A key contributing factor is intervertebral disc degeneration, which compromises spinal stability. In patients with a lack of neurological issues, conservative treatment is recommended. If conservative treatment is ineffective, surgery is deemed the next step, involving decompression and fusion of the vertebrae. Over the past several decades, minimally invasive surgical (MIS) techniques have been developed and refined. This systematic review aims to compare different types of MIS techniques for the treatment of degenerative spondylolisthesis to …

Torus Probabilistic Principal Component Analysis, Anahita Nodehi, Mousa Golalizadeh, Mehdi Maadooliat, Claudio Agostinelli

Mathematical and Statistical Science Faculty Research and Publications

Analyzing data in non-Euclidean spaces, such as bioinformatics, biology, and geology, where variables represent directions or angles, poses unique challenges. This type of data is known as circular data in univariate cases and can be termed spherical or toroidal in multivariate contexts. In this paper, we introduce a novel extension of probabilistic principal component analysis (PPCA) designed for toroidal (or torus) data, termed torus probabilistic PCA (TPPCA). We provide detailed algorithms for implementing TPPCA and demonstrate its applicability to torus data. To assess the efficacy of TPPCA, we perform comparative analyses using a simulation study and three real datasets. Our …

A Survey Study Of Roadblocks In Translational Science, Fasiha Kanwal, Christopher I Amos, Katherine H Sippel, Claudia Neuhauser, Ariel Harrison, Mary E Dickinson, Charles Minard, Bettina M Beech

Faculty, Staff and Students Publications

Clinical and translational science needs to address roadblocks to the translational processes. We conducted a survey at two institutions, a private medical school and a large public university, to understand the frequency and distribution of barriers and roadblocks to research. We reviewed the literature to compile a pool of barriers and roadblocks and convened a panel of relevant stakeholders to develop a 20-item questionnaire. Survey respondents were asked to select and prioritize the five leading clinical and translational roadblocks, provide information regarding their academic degrees and rank/position, complete open-ended items regarding their areas of research, and optionally add additional remarks …

Novel Respirometry Measurement And Comparison Of Monod Kinetic Constants And Methanogen Concentrations For 27 Full-Scale Anaerobic Bioreactors, Nicholas Benn, Antonio Martins, Daniel H. Zitomer

Civil and Environmental Engineering Faculty Research and Publications

Monod kinetic coefficient values (km and Ks) as well as methanogen concentrations (Xac and Xh2) for various anaerobic bioreactors are required to gain a deeper understanding of anaerobic biotechnology. However, there are no existing, practical methods to measure or estimate these parameters or variables in typical anaerobic digester biomass that contains mixed cultures with inert organic solids. Current measurement methods rely on pure cultures developed in the laboratory. In this work, a novel respirometric method was developed and used to determine methanogen Monod parameters and active biomass concentration for samples from 27 full-scale anaerobic reactors. Differences (one to three orders …

Negotiating Racial Subjection: Analysing Black And Indigenous Resistance From Within Colonial Orders, Owen R. Brown, Arturo Chang

Political Science Faculty Publications and Presentations

This article addresses recent work on empire and colonisation which calls for a reappraisal of how agency and resistance manifests among groups responding to structural marginalisation. We argue that approaching these questions from within the colonial order reveals important idiosyncrasies regarding how groups understood resistance, agency, and popular organising as possible responses that emerged from within imperial landscapes. Using the example of race as a central regulatory category and practice of colonial power, we analyse two cases which we suggest benefit from an account of agency and resistance within colonial order: the Black Loyalists in English America and the Indigenous …

Adapt-Marketplace - A Web-Application For Xml-Based Template Sharing In Radiation Oncology, Dennis N Stanley, Joseph Harms, Gaurav N Rathi, Joel A Pogue, Ritish Nedunoori, John B Fiveash, Richard A Popple, Carlos E Cardenas

2020-Current year OA Pubs

PURPOSE: The adaption of radiotherapy (RT) plans in response to anatomical and physiological changes during treatment marks a significant shift toward personalized cancer care. However, the complexity of Online Adaptive Radiotherapy (OART) procedures often leads to variability in treatment quality across institutions. The development of planning templates, particularly through the Ethos treatment planning system (TPS) and Intelligent Optimization Engine (IOE) (Varian Medical Systems, Palo Alto, CA), plays a crucial role in standardizing and streamlining OART. To address the challenges of sharing and optimizing treatment templates across diverse clinical environments, we developed the ADaptive rAdiotherapy Planning Template (ADAPT-) Marketplace to facilitate …

Liger-Hn Phase Iii Trials Of Petosemtamab + Pembrolizumab And Petosemtamab Monotherapy In Recurrent Or Metastatic Hnscc, Jean-Pascal Machiels, Douglas Adkins, Et Al.

2020-Current year OA Pubs

Patients with recurrent/metastatic (r/m) head and neck squamous cell carcinoma (HNSCC) have limited treatment options and a dismal prognosis, especially when their cancer is resistant to standard treatments like anti-programmed cell death protein 1 and platinum-based therapies. Petosemtamab - a human, common light chain, bispecific antibody with enhanced antibody-dependent cellular cytotoxicity targeting epidermal growth factor receptor (EGFR) and leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) - demonstrated antitumor activity in r/m HNSCC. In many tumor types, including HNSCC, EGFR is an oncogenic driver, while LGR5 is upregulated. LGR5 can potentiate the wingless-type integration site (WNT)/β-catenin signaling pathway in response to …

Reference Range Determination For The Sflt-1/Plgf Ratio In A Diverse Cohort Of Pregnant Women In The United States, Antonio F Saad, David M Haas, Eugene Chang, Scott A Shainker, Miriah Denbo, Michelle Silasi, George Saade, Sarosh Rana, Tetsuya Kawakita, Luis D Pacheco, Jennifer Powers Carson, Angela Dietl, Deirdre Allegranza, Ge Guo, David Stamilio

2020-Current year OA Pubs

BACKGROUND: The serum soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio is an established tool for predicting preeclampsia in many countries but is not widely adopted in the United States. This study aimed to determine reference ranges for the Elecsys® sFlt-1/PlGF ratio and the sFlt-1 and PlGF immunoassays (Roche Diagnostics International Ltd) in a diverse US population of healthy pregnant women.

METHODS: This was a prospective, noninterventional sample and data collection study performed between November 2022 and November 2023 at 9 collection sites and one measurement site in the United States. Evaluable women were ≥18 years old, …

A Phenomenological Study On The Enabling Role Of Digital Competencies In Heutagogical Learning Contexts, Jennifer Dean

Masters

This study examines how digital competencies contribute to independent learning within heutagogical contexts in higher education.   The research was conducted to address assumptions that digital competence directly enables learner autonomy, despite limited understanding of this empirical relationship in practice.   A qualitative hermeneutic phenomenological approach was employed, using nine semi-structured interviews to explore learners’ lived experiences in digitally mediated environments.   The findings indicate that self-directed learning is primarily driven by intrinsic motivation and often occurs unconsciously.   Digital competencies were found to act as enabling factors by facilitating access, flexibility and engagement, however, their influence on autonomy was context-dependent rather than deterministic. …

Naqbu: Cosmological Undercurrents In Sumer And Akkad, Fiona Eirene Andrews

Theses and Dissertations

The concepts of primordial incomprehensibility, ordered creation, and the liminal chaos between them, form a foundational framework in Mesopotamian intellectual culture. The distinctive ways in which these concepts manifest in Sumero-Akkadian cultures suggest a systematic cosmological substructure — characterized by the paradoxical, cyclical, and co-creative relationships between forces such as Infinity and measure, generation and destruction, and definition and obscurity — that remains insufficiently examined in current scholarship. Drawing from diverse corpus of Mesopotamian creative works, Kabbalistic exegesis, and post-modern scholarship, this thesis seeks to elucidate the essential dynamics within that substructure. By proposing a semiotic hermeneutical strategy attuned to …

Black Steel In The Hour Of Chaos: Hip-Hop And The Carceral State In The East San Francisco Bay Area, William Maclane Hull

Theses and Dissertations

“Black Steel in the Hour of Chaos: Hip-Hop and the Carceral State in the East San Francisco Bay Area” explores the histories of urban redevelopment and deindustrialization, racialized poverty, police and the carceral system, and hip-hop culture in Oakland and other parts of the eastern San Francisco Bay Area. It explores East Bay politics and urban development in the 1900s, which resulted in the flight of industries and wealthy white residents to the suburbs and the erosion of public services. Black community organizations and funk music alike articulated the damages done by these processes in the 1960s. Subsequently, politicians and …

‘If You Design For The Future To Treat Of Witches:' Diabolic Service Magicians, Astrologers, And Witchcraft In John Dunton's Athenian Mercury, 1690-1697, Lauren Rebecca Rowe

Theses and Dissertations

Originating in the print stands of seventeenth-century London, the Athenian Mercury enjoyed a nearly miraculous seven-year run time as the most well-known and successful anonymous question and answer periodical of its time. Conceptualized and produced by bookseller John Dunton, the Mercury existed as an interface for intellectual discourse readily accessible to men and women. Kept entirely anonymous on the part of the author and reader, the intellectually curious could write questions to the Mercury and receive answers in turn on a vast variety of subjects twice a week. Aside from the more expected queries on science, love, mathematics, and religion, …

Democracy’S Sanctuary: Highlander Folk School’S Campaign For Justice From The Labor Movement To The Civil Rights Movement, 1932-1962, Alexandra Elizabeth Bethlenfalvy

Theses and Dissertations

A sanctuary for political democracy, the Highlander Folk School was established in 1932 as a center for community activism, serving as the leading labor union organizing site in rural Tennessee during the Great Depression. With social unrest swelling in the 1930s, Highlander empowered workers, equipping them with the skills and knowledge needed to demand improved conditions and union representation across the anti-labor South. During World War II, however, as ranks of organized labor grew and civil rights activism in the South accelerated, Highlander convened interracial workshops, beginning in 1944, at a time when racial segregation was enforced by law and …

Birth Of Inspiration: York County, South Carolina, The Setting That Inspired The Clansman, Zachary Alan Lemhouse

Theses and Dissertations

In 1905, Thomas Dixon, Jr., published his controversial novel The Clansman. Monopolizing on racist sentiments held by white southerners, Dixon’s narrative contributed significantly to the perception of the Lost Cause myth and defense of white supremacy in America. The novel, and its subsequent adaptations as a play and the film Birth of a Nation, was inspired by actual events that occurred in Dixon’s ancestral home of York County, South Carolina. Located in the northernmost region of South Carolina’s Piedmont, York County played host to a struggle for civil rights during the Reconstruction Era that garnered national and international …

Conjuring Realities: Southern Supernaturalism And Race From The Antebellum Era To The Early Twentieth Century, Dylan T. Kobus

Theses and Dissertations

Conjure practices in the nineteenth-century American South, such as “Hoodoo” or “Voodoo,” are commonly portrayed as primarily “black” beliefs or entrenched in “Africanistic” cultures. For the enslaved, their black spiritual systems, including conjure, were a powerful tool of resistance against the white enslaver. Black conjure practitioners established themselves as an affordable and pervasive medical alternative to often ineffective or harmful professional medicines for black and white Southerners, regardless of class. In this way, conjure challenged the authority of racial capitalism and destabilized the perceived moral and intellectual superiority of whiteness. Moreover, by examining legal documents, newspapers, fictional literature, and oral …

“Cruelty, Bloodshed, And Degradation From The Inauspicious Conjunction Of Stars”: “Magic” In The 1857-58 Rebellion In India, Summer Bordon

Theses and Dissertations

During the 1857-58 rebellion in India, British soldiers and civilians saw ample evidence of Indian belief in “magic”. Prophecies about the end of British rule were implicated in inciting rebellion. When a solar eclipse occurred during the British army’s campaign to regain control of Delhi, victory was attributed partially to Indian superstition. Much of the historiography of the 1857-58 rebellion has uncritically accepted British sources’ conceptions of Indian “magic”, dismissing it as superstitious, politically hindering, and divorced from material reality. Yet, British understandings of magic cannot be taken at face value. Instead, they must be located within broader colonial narratives …

Emotional Landscapes: St. Teresa Of Avila And The Spiritual Journey, Jillian Louise Breeden

Theses and Dissertations

This paper examines the writings of St. Teresa of Avila (1515-1582) through the methodological lens of the history of emotions, arguing that her mystical accounts represent a crucial yet understudied contribution to our understanding of early modern emotional frameworks. Through close textual analysis of Teresa's major works, this study demonstrates how her detailed articulations of spiritual ecstasy, divine love, and religious melancholy offer unique insights into both the religious and secular emotional landscapes of Counter-Reformation Spain. Teresa's innovative emotional vocabulary, which combined traditional Catholic devotional language with embodied metaphors and spatial conceptualizations, allowed her to navigate the complex ecclesiastical politics …

The Penn Center’S Impact On Rural Health Through Midwife Programming In 20Th Century South Carolina, Kathryn Addison Greenberg

Theses and Dissertations

The Penn School of the Sea Islands provided an education to thousands of rural, Black South Carolinians over the twentieth century. Northern missionaries including the founders of the Penn School, Laura M. Towne and Ellen Murray, taught and provided healthcare to the residents of the Port Royal Experiment through the Civil War and into Reconstruction. With the arrival of Rossa Cooley and Grace House, the Penn School put emphasis on auxiliary programing including midwifery training institutes held in conjunction with Dr. Hilla Sheriff and the South Carolina Department of Public Health’s Division for Maternal and Child Health. With the goal …

July 2025 Library News, University Libraries

Library News

No abstract provided.

Cardiac Transplantation Does Not Improve Exercise Tolerance, Muscle Mass, Or Substrate Metabolism In Barth Syndrome, W Todd Cade, Kathryn L Bohnert, Linda R Peterson, Lisa De Las Fuentes, Emily Poehlein, Cynthia L Green, Christina A Pacak, Barry J Byrne, Dominic N Reeds, Adil Bashir, Brian Feingold, Carolyn Taylor

2020-Current year OA Pubs

Barth syndrome (BTHS) is a rare X-linked recessive disorder characterized by mutations in the TAFAZZIN gene, leading to mitochondrial dysfunction, cardioskeletal myopathy, neutropenia, exercise intolerance, and growth delay. While cardiac transplantation can improve heart function in BTHS patients, the metabolic effects of this procedure remain poorly understood. This study aimed to compare skeletal muscle morphology, substrate metabolism, energetics, and exercise tolerance in individuals with BTHS who had undergone cardiac transplantation (BTHS-T) versus BTHS patients without transplantation (BTHS-noT) and healthy controls. Six (

Toward The Professionalization Of Executive Coaching: A Delphi Study Of The Requisite Knowledge, Skills, And Abilities For Coaching Executives To Behave Ethically, Richard R. Fletcher

Electronic Theses and Dissertations

The problem explored through this research involved the lack of consensus on executive coaching knowledge, skills, and abilities for facilitating ethical behaviors on the part of business executives. This problem led the researcher to employ a mixed-method Delphi study to explore professional executive coach perceptions concerning the establishment of a governing body overseeing the activity of executive coach consulting and to assess the knowledge, skills, and abilities perceived as fundamental to executive coaching. The researcher focused the research approach through a systematic, iterative research design where a panel of six experts in the field of professional executive coaching located in …

Under The Legal Lens: Navigating Psychological Safety And Conflict For Black Women In Legal Support Roles, Chanel M. Bradden

Electronic Theses and Dissertations

The intersectional challenges of Black women in legal support roles are an overlooked phenomenon in organizational research. Despite diversity efforts in the legal profession, Black women face challenges due to gender, race, and professional status that impact their career advancement, as well as their mental and psychological well-being. As a result of experiencing the effects of racialized workplace dynamics and destructive leadership behaviors, Black women in legal support roles find resilience through self-protection strategies while working through the effects of intersecting forms of oppression in legal workspaces. This study addressed the lack of knowledge of the lived experiences of Black …

Unheard Echoes: Undocumented Students’ Success Amidst Challenges At U.S. Higher Education Community Colleges, Elvia Ortiz Segura

Electronic Theses and Dissertations

This qualitative descriptive study explored the lived experiences of undocumented Latinx students at a southern U.S. community college, identifying support services that assisted students with barriers that emerged in their academic journey. The problem of the study was the complex challenges undocumented students face in higher education and how they are addressed and supported. The research used a qualitative descriptive methodology to magnify student voices and influence institutional policies. Using Bronfenbrenner’s ecological systems theory as the theoretical framework, this study examined how family, culture, policy, and institutional systems influenced undocumented students’ educational journeys. Data were collected through semistructured interviews with …

Efforts Of Public 2-Year Higher Education Institution Leadership Reducing Nonexempt Student Affairs Employees’ Intention To Quit, Christopher M. Viser

Electronic Theses and Dissertations

This narrative qualitative study examined the influence of leadership support and workplace factors on the intentions of nonexempt student affairs employees to leave a public 2-year higher education institution (HEI) in Texas. The study addressed the issue of workplace factors contributing to these employees’ developing intentions to quit their jobs. The research focused on identifying the workplace factors that most significantly influenced nonexempt student affairs employees and explored how leadership support influenced employee experiences. The study used narrative inquiry as its methodology to gather employee narratives through semistructured interviews conducted via Zoom, a communication platform. Nine participants were selected for …

Mindful: Machine Intelligence Towards Neuropsychiatric Data For Unified Learning, Zehan Li

Dissertations and Theses (Open Access)

Suicide remains a leading cause of preventable death, with particularly high burden in underserved populations treated in safety-net psychiatric hospitals. Early detection is challenged not by the absence of data, but by the informational opacity of psychiatric clinical narratives which is unstructured, subjective, and heterogeneous records that resist traditional analytic methods. This article-based dissertation addresses this challenge by developing an integrated MINDFUL framework that combines clinically validated annotation, advanced machine learning, and explainable AI to enable accurate, interpretable suicide phenotyping in high-acuity psychiatric settings. The first study created a gold-standard annotated corpus of psychiatric notes labeled for suicidal ideation, suicide …

Clinical Assessment On Days 1-14 For The Characterization Of Traumatic Brain Injury: Recommendations From The 2024 Ninds Traumatic Brain Injury Classification And Nomenclature Initiative Clinical/Symptoms Working Group, David K Menon, Noah D Silverberg, Adam R Ferguson, Thomas J Bayuk, Shubhayu Bhattacharyay, David L Brody, Scott A Cota, Ari Ercole, Anthony Figaji, Guoyi Gao, Christopher C Giza, Fiona Lecky, Rebekah Mannix, Ana Mikolić, Kasey E Moritz, Claudia S Robertson, Abel Torres-Espin, Spyridoula Tsetsou, John K Yue, Hibah O Awad, Kristen Dams-O'Connor, Adele Doperalski, Andrew I R Maas, Michael A Mccrea, Nsini Umoh, Geoffrey T Manley

Faculty, Staff and Students Publications

The current classification of traumatic brain injury (TBI) primarily uses the Glasgow Coma Scale (GCS) to categorize injuries as mild (GCS 13-15), moderate (GCS 9-12), or severe (GCS ≤8). However, this system is unsatisfactory, as it overlooks variations in injury severity, clinical needs, and prognosis. A recent report by the National Academies of Sciences, Engineering, and Medicine (USA) recommended updating the classification system, leading to a workshop in 2024 by the National Institute of Neurological Disorders and Stroke. This resulted in the development of a new clinical, biomarker, imaging, and modifier (CBI-M) framework, with input from six working groups, including …