Digital Commons Network^™

Genetic Study Of Von Willebrand Factor Antigen Levels ≤ 50 Iu/Dl Identifies Variants Associated With Increased Risk Of Von Willebrand Disease And Bleeding, Rachel K Friedman, Adam S Heath, Jennifer E Huffman, James T Baker, Natalie R Hasbani, Sarah A Gagliano Taliun, Ming-Huei Chen, Tom E Howard, Joshua P Lewis, Nathan Pankratz, Snehal Patil, Alex P Reiner, Florian Thibord, Lisa R Yanek, Jie Yao, Hung-Hsin Chen, Joanne E Curran, Nauder Faraday, Xiuqing Guo, Marsha M Wheeler, Kathleen A Ryan, Xiang Zhou, Kelly Cho, Laura Almasy, Paul L Auer, Lewis C Becker, Peter W F Wilson, Eric Boerwinkle, Jeffrey R O'Connell, Stephen S Rich, David C Samuels, National Heart, Lung And Blood Institute (Nhlbi) Trans-Omics For Precision Medicine (Topmed) Consortium, Topmed Hematology & Hemostasis Working Group, Va Million Veteran Program, John Blangero, Myriam Fornage, Charles Kooperberg, Rasika A Mathias, Braxton D Mitchell, Jerome I Rotter, Andrew D Johnson, Nicholas L Smith, Zeynep H Coban-Akdemir, Jennifer E Below, Alanna C Morrison, Jill M Johnsen, Paul S De Vries

Faculty, Staff and Student Publications

Background: von Willebrand disease (VWD) is a common inherited bleeding disorder caused by low levels or activity of circulating von Willebrand factor (VWF). Genetic susceptibility to VWF antigen (VWF:Ag) below normal (≤ 50 IU/dL) in the general population is underexplored.

Objectives: To identify genetic variants influencing VWF:Ag levels ≤ 50 IU/dL.

Methods: We performed a genome-wide association study in 926 cases with VWF:Ag levels ≤ 50 IU/dL and 12 846 controls from 7 studies from the Trans-Omics for Precision Medicine program. We then examined whether significant genome-wide findings were also associated with clinical diagnosis of VWD in 5 biobanks with …

Language Brokering Conditions The Indirect Association Between Mexican‐Origin Adolescents’ Academic Discrimination And Educational Expectations, Su Yeong Kim, Yayu Du, Chantal Alvarado, Wei Xiang Sim, Wen Wen, Tianlu Zhang, Jingyi Shen

Research Collection School of Social Sciences

Mexican‐origin adolescents, a significant portion of the US Latino population, often experience a decline in educational expectations from early to late adolescence. Contextual factors such as academic discrimination and language brokering for parents may contribute to this decline. This study investigates the indirect effect of academic discrimination experienced in middle school on educational expectations in young adulthood through high school grades and engagement, and the moderating role of language brokering experiences in these relations. Data were collected from 604 Mexican‐origin adolescents across four waves from 2012 to 2023. Academic discrimination experiences in middle school were negatively associated with school grades …

Internet Of Things And Modern Digital Evidence Collection, Muhammad T. Haider

Student Theses

The ever-evolving landscape of technology and its innovations are populating our houses, streets and all kinds of industries. The use of smart devices is booming from most developed nations to underdeveloped countries. The complications which come with the use of the Internet of Things has been an active discussion for the past many years. If we look around in a room of 30 people, we will most likely find double the amount of IoT devices than the people in that room. All of those devices are connected to the Internet, and are communicating with data servers across the world. The …

Cg18562578 Methylquant Assay For The Discrimination Of Monozygotic Twins, Amber P. Chauca

Student Theses

Monozygotic (MZ) twins have identical DNA, making traditional profiling methods insufficient in their discrimination. However, MZ twins can be differentiated by their levels of DNA methylation. Our research group previously developed a methodology to detect cg18562578 DNA methylation levels in MZ twins based on a two- step PCR approach and a cg18562578 MethylQuant Assay. That study generated data for only 64% of the samples it investigated, and showed a discrimination power of 77% to discriminate between MZ twins. Here, we used the same methodology but a different approach to determine DNA methylation in 73 previously unsuccessful twin pairs. We diluted …

Further Investigation Of Environmental Factors On Rapid Shear In Fibers Of A Polyester-Cotton Blend, Daniel K. Oh

Student Theses

Rapid shear is a process that occurs in thermoplastic materials when they interact with a high-velocity impact. In forensics, these interactions would typically be from a bullet interacting with clothing that consisted of synthetic fibers. When the interaction occurs, bulb-like shapes appear on damaged fiber ends, distinguishing them from other kinds of damage. The reason why these shapes occur is varied, but one prevailing factor seems to be the heat generated by the impact.

In prior experiments, the factor of temperature being important to the formation of the phenomenon, different environmental simulations that affected the sample’s temperature were done on …

Bystanders Intervening During Acts Of Cyberbullying: Examining The Moderating Influence Of “Likes” And Pleas For Help, Joseph Kallman

Student Theses

Abstract

Cyberbullying research has only recently begun exploring “cyberstanders,” also known as bystanders, and their role in cyberbullying, as well as testing the bystander effect (Barlinska et al., 2013; Machackova et al., 2013; Obermaier et al., 2016; Shultz et al., 2014). In the current study, we aim to deepen our understanding of the bystander effect by manipulating the number of likes, which will indicate the number of bystanders present and the plea for help on social media via Twitter among college students, by examining how participants respond to fictitious cyberbullying incidents. The results of this study did not support our …

Impaired Rest-Activity Rhythm Characteristics Predict Higher Risk Of Incident Type 2 Diabetes In Uk Biobank Participants, Chris Ho Ching Yeung, Alison K Wright, Daniel P Windred, Angus C Burns, Andrew J K Phillips, Sean W Cain, Martin K Rutter, Qian Xiao

Faculty, Staff and Student Publications

Objective: Circadian rhythms play a key role in metabolic health. Rest-activity rhythms, which are in part driven by circadian rhythms, may be associated with diabetes risk. There is a need for large prospective studies to comprehensively examine different rest-activity metrics to determine their relative strength in predicting risk of incident type 2 diabetes.

Research design and methods: In actigraphy data from 83,887 UK Biobank participants, we applied both parametric and nonparametric algorithms to derive 13 different metrics characterizing different aspects of rest-activity rhythm. Diabetes cases were identified using both self-reported data and health records. We used Cox proportional hazards models …

Trends In Glucagon-Like Peptide 1 Receptor Agonist Prescribing Patterns, Maria Ukhanova, Joseph S Wozny, Chau N Truong, Lopita Ghosh, Trudy M Krause

Faculty, Staff and Student Publications

Objective: Obesity affects more than 40% of US adults, increasing risks for cardiovascular disease and type 2 diabetes. Glucagon-like peptide 1 receptor agonists (GLP-1 RAs), initially indicated for diabetes, show promise in weight loss but face coverage issues, high costs, and premature prescribing from physicians. Research is needed to assess prescribing patterns, especially in patients without diabetes.

Study design: We conducted a retrospective, population-based, observational study using the Merative MarketScan Commercial Database and the Merative MarketScan Medicare Supplemental Database, which capture person-specific clinical utilization and expenditures. We analyzed GLP-1 RA prescribing rates from 2018 to 2023, comparing semaglutide with other …

Computational Frameworks To Unravel The Immune Landscape, Shan He

Dissertations and Theses (Open Access)

Recent advances in immunotherapy, including immune checkpoint blockade (ICB) and adoptive cell therapy, face challenges such as resistance and immune-related adverse events, partly due to our limited understanding of the immune signaling pathways. While high- throughput genomic data provide unprecedented resolution into these immune pathways, their full potential is limited by the lack of well-annotated, context-specific immune gene sets. To address this need, I developed a workflow to construct immune gene sets by integrating RNA- seq datasets and performing decomposition. Using this approach, I constructed 28 immune- specific gene sets from 83 bulk RNA-seq datasets and 12 Natural Killer (NK) …

Use Of The Protein Misfolding Cyclic Amplification For Food Safety And Drug Discovery, Maria R. Benavente Garcia-Huidobro

Dissertations and Theses (Open Access)

Prion diseases are fatal neurodegenerative disorders caused by the misfolding of the normal prion protein (PrP^C) into its infectious form (PrP^Sc). While the zoonotic potential of chronic wasting disease (CWD) remains uncertain, the presence of prions in food products raises public health concerns. Additionally, therapeutic strategies for prion diseases remain limited. This thesis presents a methodological exploration of the Protein Misfolding Cyclic Amplification (PMCA) technique to address these challenges in two key areas: (1) detecting CWD prions in processed meats subjected to common cooking procedures, and (2) identifying potential anti-prion compounds through a high-throughput PMCA adaptation. …

Effects Of Sex And Aging In The Response To Global Cerebral Hypoperfusion, Alexis Mcalister

Dissertations and Theses (Open Access)

Introduction

The prevalence of dementia worldwide is projected to double by the year 2030 and triple by 2050. Vascular cognitive impairment and dementia (VCID) encompasses diseases that lead to cognitive decline and dementia due to cerebrovascular disease. VCID is the second most common form of dementia after Alzheimer’s disease, accounting for approximately 15- 40% of all dementia cases. Reductions in cerebral blood flow from intracranial and extracranial atherosclerosis increase VCID risk, even in the absence of overt clinical or imaging evidence of stroke/embolization. The pathology seen in patients with chronic cerebral hypoperfusion, such as inflammation, neuronal loss, white matter abnormalities, …

Microbial Metabolite Regulation Of Microglial Ahr Signaling In Alzheimer’S Disease, Ghalya E. Alrousan

Dissertations and Theses (Open Access)

Introduction: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β plaque accumulation, neuroinflammation, and cognitive decline. Recent evidence suggests that systemic factors, particularly the gut microbiota and its metabolites, play a significant role in shaping brain immune responses, including microglial activation. However, the mechanisms linking gut dysbiosis to microglial dysfunction in AD are poorly understood. The aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor responsive to tryptophan metabolites, has recently gained attention as a key regulator of neuroinflammation and microglial function. I hypothesize that the loss of beneficial microbial AHR ligands, specifically indole derivatives, during aging and AD …

The Effects Of A Tier 2 Intervention On The Behavior Of Elementary School Students Participating In Second Step: Enhancing A Schoolwide Social-Emotional Learning Curriculum, Charlotte Annalee Kennington

Theses and Dissertations

After reviewing the current research literature on the effects of social-emotional learning (SEL) on the behavior of elementary-age children, it was clear that there was limited research data on the effects of Tier 2 interventions designed to augment the effects of schoolwide SEL programs. Specifically, to what extent could a brief, group-delivered intervention improve the academic engagement, problem behavior, and socially appropriate comments of fifth-grade students receiving schoolwide SEL through Second Step in a traditional public school? Three fifth-grade students were recruited to participate in this study who all engaged in frequent problem behavior during Second Step lessons and throughout …

The Experiences Of Elite, Female Club Volleyball Players – An Interpretative Phenomenological Analysis, Chelsea Brehm

Dissertations

The purpose of this qualitative study was to investigate the lived experiences of female athletes participating in national-level club volleyball in a Midwestern U.S. state. Amid increasing sport privatization and a growing emphasis on early sport specialization, female athletes in club volleyball are navigating complex pressures tied to elite competition, college recruitment, and psychosocial well-being. Using Interpretative Phenomenological Analysis (IPA), this study sought to uncover how athletes experience and make meaning of their participation in this highly demanding sport structure.

Data collection included a demographic survey distributed to national-level athletes (n = 66) and in-depth, semistructured interviews with five female …

Burning The Wick At Both Ends: A Three Paper Investigation Of Burnout And Educators, Karla P. Miner

All Dissertations

Researchers in the late 20th century identified the impact of burnout on organizational and individual success. The urgency to address burnout in education has intensified following the disruptions caused by the COVID-19 pandemic. Teacher burnout, characterized by exhaustion, cynicism, and feelings of inadequacy, has been a commonly discussed topic among educators internationally following the COVID-19 pandemic. Recent studies highlight the alarming rates of burnout among educators, emphasizing the need for targeted interventions to support well-being and mitigate educator attrition. This collection of papers addresses three primary aspects of burnout and practice: a literature review of individual and organizational practice, a …

Designing Multilingual (Maker) Spaces: Exploring The Intersections Of Play, Posthumanism, And Pre-Kindergarten, Victoria G. Pennington

All Dissertations

In this dissertation, I explore the posthuman play literacies of multilingual makerspaces with four-year-olds, emphasizing the need for such a study while situating my arguments within the existing literature and outlining my methodological approach. Chapter One critiques the public 4-year-old kindergarten systems, arguing institutionalized cultural and linguistic ideologies restrict multilingual learners’ (MLs) opportunities for meaning-making. I draw on the raciolinguistic perspective (Flores & Rosa, 2015) and its intersection with a posthumanist paradigm (Braidotti, 2013), framing my research questions as lines of inquiry to guide the study. Key posthumanist literacies concepts are defined, highlighting the entanglement of literacies, discourses, materials, and …

Advancing Life Cycle Assessment For Environmental Sustainability Of Carbon Fiber-Reinforced Polymer Composites (Cfrps)), Hao Chen

All Dissertations

Carbon fiber-reinforced polymer composites (CFRPs) have emerged as promising materials, particularly for lightweight applications, with the potential to reduce environmental impacts across multiple sectors, including automotive, aerospace, and renewable energy. However, fully realizing their sustainability potential requires a more comprehensive and context-specific understanding of their environmental performance throughout the entire life cycle—from raw material production to end-of-life management.

This dissertation advances life cycle assessment (LCA) practices for CFRPs by addressing key challenges across multiple phases of the CFRP life cycle. First, I conducted a critical review and meta-analysis of carbon fiber manufacturing, revealing substantial variability in reported data on energy …

Influence Of Experience And Risk With Natural Hazards On Geoscience Interest And Career Expectations, Shannon Conner

All Dissertations

Understanding student interest in geoscience is important, as it has the potential to inform departmental decisions such as the selection of classroom examples and marketing strategies to attract new geoscience majors. Recruitment to geoscience is critical to address future social and environmental challenges. Our work may also provide insight into how to approach persistent recruitment problems within departments, such as student enrollment and the lack of diversity within the geosciences. This work involves developing a geoscience interest scale, integrating geospatial and educational data sets related to hazard risk and interest, and an exploring career motivations as related to natural hazard …

Transforming Childhood Adversity Into Executive Excellence: Impact On Firm Performance, Kimberly Byars

All Dissertations

Many successful business leaders have overcome difficult childhoods, yet little research has examined how early hardships might actually contribute to leadership effectiveness. This study investigated whether CEOs who experienced childhood adversity can transform these difficult experiences into strengths that improve their companies' performance.

The research surveyed 165 business owners across two groups: general business owners and automotive dealership owners. Participants answered questions about their childhood experiences, their ability to grow from trauma, and various psychological traits like grit, mental toughness, resilience, and growth mindset. Company performance data was also collected.

The findings challenge conventional wisdom that difficult childhoods necessarily harm …

Melts To Solutions: Structure, Dynamics, And Response Of Polyelectrolytes, Shalika Meedin

All Dissertations

The current research elucidates the changes in the structure and motion of polyelectrolytes as they are perturbed by solvents and shear flows. Polyelectrolytes are macromolecules whose backbone consists of long, predominantly hydrocarbon chains, substituted by ionizable groups, which tend to dissociate into ions in polar solvents. Their properties result from a delicate balance of elastic energy that arises from the polymeric backbone and electrostatic forces, which stem from the ionizable groups. Though polyelectrolytes have an immense potential to propel numerous technologies, from clean energy to drug delivery systems, understanding the delicate balance between the properties of the polymer backbone and …

Evaluating Covid-19, Influenza, And Rsv Vaccine Effectiveness, Iromi N. Jayawardena

All Dissertations

Respiratory infectious diseases, including COVID-19, influenza, and RSV, pose significant public health challenges, especially during the respiratory virus season. Vaccination remains the primary intervention to mitigate morbidity and mortality associated with these diseases. Vaccine effectiveness (VE) can vary between seasons and populations, necessitating continuous evaluation. This study aims to evaluate the effectiveness of the 2024-2025 COVID-19 mRNA vaccine, 2024-2025 seasonal influenza vaccine, and single-dose RSV vaccine over two seasons.

Utilizing electronic health records (EHRs) from the Prisma Health healthcare system, this dissertation emulated target trials to assess the vaccine effectiveness of each vaccine. Risk set propensity matching was used to …

Culturally Relevant Pedagogy In Undergraduate General Chemistry, Destinee J. Cooper

All Dissertations

General chemistry is a foundational course for advancement in most undergraduate STEM programs, but unfortunately, many students do not continue in STEM after their experiences in their general chemistry course. Culturally relevant pedagogy (CRP) has the potential to increase students’ positive experiences in general chemistry by centering their needs, identities, and backgrounds. However, this pedagogical approach has not been widely studied in the college general chemistry context. As such, my four-paper dissertation broadly aimed to explore both the implementation and outcomes of CRP in undergraduate general chemistry.

The first paper reviewed the literature on culture-based pedagogies across the full undergraduate …

Black Women Policymakers And Black Feminist Approaches In United States Gender-Based Violence Policies: Analyzing Policy Making, Institutional, And Social Media Discourse Through The Narrative Policy Framework, Gugu Selela

All Dissertations

This research study examines how gender-based violence (GBV) policy in the United States marginalizes Black women through race-neutral language and punitive frameworks. Despite facing disproportionate violence, Black women are often excluded from policy narratives, debates, and institutional priorities. Grounded in Black Feminist Thought and the Narrative Policy Framework, this study investigates how exclusion operates across legislative, digital, and institutional domains, and how Black women in public service resist and reshape GBV policy through care-centered, survivor-informed practices. Focusing on the U.S. South, the study uses a qualitative, multi-method design. It analyzes ninety-three Senate committee transcripts from South Carolina, North Carolina, and …

Emotional Safety In Pediatrics: The Impact Of Child Life Services On Healthcare Professionals’ Perceptions Of Their Own, Patients’, And Families’ Outpatient Experiences, Jenni Davis

All Dissertations

Medical visits, regardless of setting, are stressful for children and their families. Care that focuses on the emotional safety of children and families can help reduce this stress. However, not all staff feel prepared to provide emotionally safe care. Child life specialists (CLSs) are specifically trained to support emotional needs during healthcare encounters. Their presence may help staff stress as well, not just stress for children and families.

This study used three surveys to understand stress among healthcare staff working in pediatric outpatient clinics and surgery settings, and how support from a CLS affects staff, children, and families. All staff …

Are They Ready? Impacting Kindergarten Readiness Through The Science Of Reading, Traci T. Boyles

All Dissertations

The purpose of this research study was to investigate how Science of Reading (SOR) professional development for preschool teachers, implemented through collaborative teaching and assessment cycles, influences the kindergarten readiness of preschool students.

Students from impoverished families start kindergarten at a considerable disadvantage regarding literacy. Literacy-focused curricula and professional development for teachers strongly affect reading outcomes. Multi-Tiered Systems of Support (MTSS) provides a systemic framework for data-based problem solving and decision-making. The MTSS framework aligns literacy interventions with tiered supports to ensure all students receive the assistance they need to achieve reading proficiency.

The South Carolina Child Early Reading Development …

Ecomorphological Diversification Of Tooth Complexity In The Oral Jaws Of Marine Teleostean Fishes, Keiffer L. Williams

All Dissertations

Teeth are essential biological tools that function as a direct interface between predator and prey, thus providing essential insights into the evolutionary history and ecological diversity of vertebrates. Historically, studies on vertebrate dentitions have been qualitative and focused on mammals. More recently, quantitative methods have been developed that can reliably measure tooth surface complexity. These methods have been applied across both mammals and saurian reptiles to test for correlations with diet, leading to the conclusion that herbivorous species generally possess higher overall tooth complexity than any other dietary group. Surprisingly, the relationship between tooth complexity and diet in the most …

From Cities To Ranches: Assessing Public Support For Jaguar (Panthera Onca) Conservation And Livestock Predation In Colombia, Luz Angelica Solano

All Dissertations

Jaguars are among the most emblematic large carnivores worldwide. Nonetheless, the species has declined by 25% in less than 25 years and their range has been reduced by 55%, approximately, primarily due to habitat loss from increasing agricultural development, retaliatory killings from human-jaguar conflict, and overhunting of their natural prey. Given the anthropogenic nature of these threats, developing effective coexistence strategies and public support for jaguar conservation are increasingly urgent for the continued persistence of this species. I conducted a scoping review to assess trends and gaps in the existing peer-reviewed literature, grey literature, and news articles related to human-jaguar …

Issues In Contrasting Conservative And Considered Estimation: A Reply To Bobko Et Al. (2024), Paul R. Sackett, Christopher M. Berry, Filip Lievens, Charlene Zhang

Research Collection Lee Kong Chian School Of Business

Bobko et al. (2024) responded to Sackett et al.'s (2022) compilation of meta-analytic evidence for the validity of a wide variety of measures used as predictors of overall job performance, offering a set of alternative methodological choices which they term “considered estimation” to counter the Sackett et al. approach of “conservative estimation.” Here we offer a rebuttal to Bobko et al. A primary concern is that Bobko et al. apply the label “conservative estimation” to the full range of methodological choices made by Sackett et al. Yet, we clarify the narrow and specific meaning of “conservative estimation,” and note that …

From Classroom To Workplace: Evaluating Communication Curriculum In Physician Assistant Education, Camryn G. Evett

Honors Thesis

Effective communication is a critical competency for physician assistants (PAs), impacting patient outcomes, interprofessional collaboration, and clinical decision-making. This paper explores the many communication challenges faced by PAs, including navigating supervisory relationships, clarifying scope of practice, building patient trust, and managing clinical interactions. It also examines how the national accrediting and certifying bodies such as the Accreditation Review Commission on Education for the Physician Assistant (ARC-PA), the National Commission on Certification of Physician Assistants (NCCPA), and professional organizations such as the American Academy of Physician Associates (AAPA) shape communication training through formal standards. These frameworks influence curricular design, assessment methods, …

Jury Decision Rules In Criminal Trials, Emma Archibald

Dalhousie Journal of Legal Studies

Discussions of juries in democratic systems often frame the jury as a symbol of democracy, an essential safeguard for an accused, and a legitimizer of state authority. However, the context in which the jury operates has evolved, and there is a widening gap between our empirical understanding of juries and our commitment to their theoretical value. Piecemeal reforms of the jury have also moved the system away from the historical model, with the consequence of undermining the remaining aspects. This paper argues one such aspect is the decision rule under which a jury renders its verdict. Canada is one of …