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The Pastoral Ministry Perspective Of Church Librarians, Ka Lim Cheung Aug 2025

The Pastoral Ministry Perspective Of Church Librarians, Ka Lim Cheung

The Christian Librarian

This article explores the pivotal role of church librarians from a ministry perspective, highlighting their importance in fostering spiritual growth and knowledge dissemination within congregations. It articulates the essence of ministry, emphasizing accountability to God and the spiritual significance of knowledge, as rooted in biblical teachings. The article outlines the multifaceted responsibilities of librarians, including resource management, communication, and relationship building, while advocating for a holistic approach that addresses congregants’ diverse needs. Furthermore, by highlighting the values of empathy, service, and hospitality, the article illustrates how librarians can create a welcoming atmosphere that encourages engagement with faith. It also explores …


Infusing Ot Principles Into A Program For Women Survivors Of Domestic Violence, Lark M. Wilkerson, Mary Jan Greer, Kim Broussard, Wendy Tremaine Aug 2025

Infusing Ot Principles Into A Program For Women Survivors Of Domestic Violence, Lark M. Wilkerson, Mary Jan Greer, Kim Broussard, Wendy Tremaine

Summer 2025 OTD Capstone Symposium

This capstone project proposes the development and implementation of a trauma-informed occupational therapy (OT) program designed to support women survivors of domestic violence. Grounded in trauma-informed care principles, the program aims to address the psychosocial, emotional, and functional disruptions commonly experienced by survivors, including trauma-related stress, anxiety, and difficulty engaging in meaningful daily activities. A comprehensive needs assessment informed the development of structured interventions focused on improving emotional regulation, promoting self-care, fostering social participation, and enhancing overall occupational performance. Using both qualitative and quantitative methods, the project evaluates changes in participants’ functional abilities, psychosocial well-being, and perceived quality of life. …


The Benefits Of Music In Occupational Therapy For Individuals With Dementia, Keanu Butler, Rebecca King, Keegan Mckay Aug 2025

The Benefits Of Music In Occupational Therapy For Individuals With Dementia, Keanu Butler, Rebecca King, Keegan Mckay

Summer 2025 OTD Capstone Symposium

Alzheimer’s disease is the most common cause of dementia in older adults, leading to progressive declines in memory, behavior, and daily functioning. Music interventions, whether live or recorded, have been shown to improve mood, reduce agitation, and enhance quality of life for individuals with dementia by fostering emotional connection and relaxation. The Model of Human Occupation supports these interventions by addressing volition, routines, and performance skills, helping therapists create meaningful, structured strategies to improve daily living and engagement.


Improving Effective Assistant Nurse Manager Communication In Obstetrics, Julie Marie Glover Aug 2025

Improving Effective Assistant Nurse Manager Communication In Obstetrics, Julie Marie Glover

Master's Projects and Capstones

Abstract

Problem: This quality improvement project addresses inconsistent leadership communication among Assistant Nurse Managers (ANMs) in the Obstetrics (OB) department of a hospital in Northern California. ANM and staff concerns around shift handoff, huddles, and leadership responsiveness have created confusion and hindered team coordination. The project aims to improve communication effectiveness scores among OB ANMs from 50% to 75% by July 11, 2025.

Context: The project was conducted in the Maternal-Child-Health (MCH) unit of a hospital in Northern California, specifically targeting communication practices among OB ANMs. Concerns around communication practices were voiced by both ANM leadership and frontline staff, signaling …


The Anti-Work Attitude Scale: Conceptualizing And Measuring The Resistance To The Institution Of Work, Alayna Del Rosario Aug 2025

The Anti-Work Attitude Scale: Conceptualizing And Measuring The Resistance To The Institution Of Work, Alayna Del Rosario

Master's Theses

Recent shifts in labor discourse have drawn attention to rising burnout, declining organizational commitment, and diminishing job satisfaction, which challenge traditional assumptions about the centrality and desirability of work. These tensions have given rise to the concept of anti-work, a growing discourse that questions the moral, economic, and psychological foundations of work itself. Despite its cultural relevance, anti-work remains largely undertheorized and unmeasured in empirical research. Drawing from interdisciplinary scholarship, this study defined anti-work as a negative critique of work as a social construct, questioning its value, purpose, and impact on individuals and society. Anti-work was operationalized through two higher-order …


Different Hypoxic Response Of Human Cavii And Caenorhabditis Elegans Homologous Genes Cah-3, Cah-4, Cah-5, Sümeyye Aydoğan Türkoğlu, Aysu Bozkurt, Fatma Poyrazli, Derya Okuyan Aug 2025

Different Hypoxic Response Of Human Cavii And Caenorhabditis Elegans Homologous Genes Cah-3, Cah-4, Cah-5, Sümeyye Aydoğan Türkoğlu, Aysu Bozkurt, Fatma Poyrazli, Derya Okuyan

Turkish Journal of Biology

Background/aim: A number of carbonic anhydrase (CA) family proteins have been implicated in cancer. They contribute to the hypoxic microenvironment. CAVII is often downregulated in colorectal carcinoma and it has been associated with increased tumor size, node metastasis, and adverse clinical outcomes. In this study, we aimed to investigate the effect of hypoxia on CAVII protein in human colon cancer and prostate cancer cells. In addition, the regulation of CAH genes in Caenorhabditis elegans was examined. These are homologous to CAVII in humans.

Materials and methods: CAVII expression was analyzed in different cell lines such as human colon cancer (SW480 …


Grade 3-5 Teacher Experiences Using Digital Learning Tools In Mathematics Instruction, Dorothy Yun Aug 2025

Grade 3-5 Teacher Experiences Using Digital Learning Tools In Mathematics Instruction, Dorothy Yun

Walden Dissertations and Doctoral Studies

The problem that was addressed through this study was that Grade 3–5 mathematics teachers in Chicago suburban elementary schools (CSES) faced challenges integrating digital learning tools (DLTs) to support student achievement after the COVID-19 pandemic forced a rapid transition to technology-based instruction. The purpose of this qualitative study was to explore CSES Grade 3-5 teachers’ experiences using DLTs in mathematics instruction. Guided by the technological pedagogical content knowledge framework, two research questions explored how teachers used DLTs in instruction, and what resources or supports were needed for effective implementation. For this basic qualitative design, 15 certified Grade 3–5 teachers, who …


Causes, Consequences, And Countermeasures Of Military Coups In The Gambia, Alhagie A. Mbye Aug 2025

Causes, Consequences, And Countermeasures Of Military Coups In The Gambia, Alhagie A. Mbye

Walden Dissertations and Doctoral Studies

Military coups d’état remain a persistent threat to postcolonial African states, undermining democratic consolidation and institutional legitimacy. The Gambia, although historically regarded as a relatively stable West African nation, has experienced approximately 14 coup attempts since gaining independence from Great Britain in 1965. While military coups in Africa are well documented, much of the existing literature relies on broad regional frameworks that emphasize externalities such as foreign influence and geopolitical pressures rather than internalities such as national policy direction, and domestic governance challenges. The purpose of this qualitative case study is to address that gap by providing context-specific empirical research …


Enhanced Global Oil Spill Dataset From 1967 To 2023 Based On Text-Form Incident Information, Yiming Liu, Zhuoli Yin, Hua Cai Aug 2025

Enhanced Global Oil Spill Dataset From 1967 To 2023 Based On Text-Form Incident Information, Yiming Liu, Zhuoli Yin, Hua Cai

The School of Sustainability Engineering and Environmental Engineering (SEE) Faculty Publications

Knowing how much oil was released into the environment in each incident is critical to studying the environmental, ecological, and economic impacts of oil spills. However, the release amounts (RAs) for numerous oil spill incidents remain unavailable in a structured format for large-scale analysis. The most extensive global oil spill database, managed by NOAA’s Office of Response and Restoration, only documents the worst-case scenario estimations in the machine-readable dataset, while more accurate values are embedded within unstructured incident descriptions and subsequent updates. To enhance the dataset with more accurate RAs, we developed a framework to extract the actual RAs from …


Reviewing The Need For Subject-Specific Regional Professional Development Opportunities For Business Librarians, Annette Bochenek, Heather A. Howard Aug 2025

Reviewing The Need For Subject-Specific Regional Professional Development Opportunities For Business Librarians, Annette Bochenek, Heather A. Howard

Libraries Faculty and Staff Scholarship and Research

This paper reviews the need for regional professional development opportunities for business librarians, examining the benefits and drawbacks that business librarians experience when attending national, subject-specific, and regional conferences, from the perspective of the creators and organizers of the Midwest Business Librarian Summit (MBLS). Using information gained regarding what benefits librarians seek when considering conference attendance as well as the obstacles or challenges experienced, this paper offers information about extant regional conferences for business librarians as well as suggestions for developing an in-person, subject-specific regional conference targeted toward business librarians.


Wellness Tourism: An Introduction, Karen Thal Aug 2025

Wellness Tourism: An Introduction, Karen Thal

All Open Educational Resources

Wellness tourism is a growing segment of the travel industry that focuses on experiences designed to improve physical, psychological, and spiritual well-being. From yoga retreats and spa getaways to outdoor adventures and healthy culinary experiences, this form of tourism reflects a broader cultural shift toward self-care and holistic health. The current textbook introduces wellness tourism in a U.S. context, offering a practical, business oriented overview for undergraduate students. It provides insights into the concept of wellness, defines and examines both the wellness industry and the wellness tourism sub-sector, highlights key trends, explores the motivations of wellness travelers, and explains how …


Summer Commencement: August 8, 2025, University Of North Dakota Aug 2025

Summer Commencement: August 8, 2025, University Of North Dakota

UND Commencement Programs

UND Summer Commencement program from August 8, 2025.


Refugee Families: Parental Traumatic Stress And Child Outcomes A Scoping Review, Britta Sedig Aug 2025

Refugee Families: Parental Traumatic Stress And Child Outcomes A Scoping Review, Britta Sedig

Theses and Dissertations

This scoping review synthesizes recent literature (2019-2024) to explore mechanisms linking parental trauma to child mental health outcomes within refugee families. Guided by a systemic and relational focus, 20 studies were identified and analyzed, revealing five central themes: intergenerational transmission of trauma, parenting practices as mediators, parent-child dyadic attachment, family functioning and conflict, and post-migration and acculturative stress. Findings highlighted associations between parental trauma-related symptoms and refugee children's emotional and behavioral concerns. Parenting practices were frequently linked to child wellbeing, with some studies identifying risk factors like harsh discipline and emotional unavailability, and others noting protective roles of intentional caregiving. …


The Use Of A Horizontal Reference Line While Measuring The Anterior Center Edge Angle Is More Reliable Than The Traditional Method, Roland Howard, Benjamin Miltenberg, William Johns, Neel Patel, Shyam Brahmabhatt, John Salvo Aug 2025

The Use Of A Horizontal Reference Line While Measuring The Anterior Center Edge Angle Is More Reliable Than The Traditional Method, Roland Howard, Benjamin Miltenberg, William Johns, Neel Patel, Shyam Brahmabhatt, John Salvo

Rothman Institute Papers

BACKGROUND: The anterior center edge angle (ACEA) is a radiographic parameter commonly utilized for the assessment of anterior acetabular coverage in the setting of various hip abnormalities. However, this measurement is greatly dependent on patient positioning and imaging technique.

PURPOSE: To evaluate the utility of a measurement technique utilizing a horizontal reference line and femoral head perfect circles for better control of pelvic obliquity and the assessment of its potential as a more reproducible method for determining the ACEA.

STUDY DESIGN: Cohort study (diagnosis); Level of evidence, 3.

METHODS: There were 3 authors who retrospectively reviewed the false-profile radiographs of …


Exploration Of The Cultural Beliefs, Values, And Practices Of African American/Black Women Or Birthing Persons Regarding Postpartum Depression: A Focused Ethnography, Stephanie Jacobs Aug 2025

Exploration Of The Cultural Beliefs, Values, And Practices Of African American/Black Women Or Birthing Persons Regarding Postpartum Depression: A Focused Ethnography, Stephanie Jacobs

Electronic Theses and Dissertations

Introduction: Postpartum depression (PPD) is the most prevalent perinatal mental health illness in women, affecting approximately 10% to 20% of all women in the United States, and a disproportionately higher number of African American women. The aim of this study was to explore the cultural beliefs, values, and practices of African American/Black women or birthing persons regarding postpartum depression.

Research Question: What are the cultural beliefs, values, and practices of African American/Black women or birthing persons regarding postpartum depression?

Methodology: A focused ethnography was chosen for this study and consisted of semi-structured interviews. Data was transcribed and analyzed …


Recreational Boat Fishing Participation Varies Across Bioregional Fisheries In Western Australia, With Persistent Patterns Within Fisheries And Fisher Typologies Over Time, Karina L. Ryan, Eva Lai, Claire B. Smallwood, Jeremy M. Lyle, Kate E. Stark, Sean R. Tracey Aug 2025

Recreational Boat Fishing Participation Varies Across Bioregional Fisheries In Western Australia, With Persistent Patterns Within Fisheries And Fisher Typologies Over Time, Karina L. Ryan, Eva Lai, Claire B. Smallwood, Jeremy M. Lyle, Kate E. Stark, Sean R. Tracey

Fisheries Research Articles

Recreational fishing is popular worldwide and understanding variability in participation can inform policies that seek to improve sustain[1]ability of recreational fisheries and amenity for recreational fishers. However, not all recreational fishers are alike in their demographics or behaviours. This study explores temporal and spatial variability in licensed boat-based recreational fishing participation in Western Australia using data from a consistent survey design delivered 12 times from 2011 to 2024. Five fisher participation typologies were identified across four marine bioregions (North Coast, Gascoyne Coast, West Coast, and South Coast) and four fishery types (demersal, nearshore, pelagic, and invertebrate) with varied fisher characteristics …


Eco-Emotions And Climate Activism In Adolescents, Julianna Sahoo Aug 2025

Eco-Emotions And Climate Activism In Adolescents, Julianna Sahoo

Master's Projects and Capstones

Background. Youth are especially vulnerable to climate change, both physically and psychologically. Combatting climate change will require a coordinated, global effort. Understanding the motivations and emotions behind climate activism is essential to coordinate efforts to combat climate change.

Methods. This research uses survey data collected from first and second year undergraduates (n=521) at a private, urban university in California in the Fall of 2022. Youth were surveyed on emotions related to climate change, activism, compassion, eco-anxiety, and well-being.

Results. Experiencing positive emotions had a stronger relationship with environmental activism compared to negative emotions.

Conclusion. Results suggest climate change communications should …


Reducing Nulliparous, Term, Singleton, Vertex Cesarean Birth Rate, Roseanna Juarez Aug 2025

Reducing Nulliparous, Term, Singleton, Vertex Cesarean Birth Rate, Roseanna Juarez

Master's Projects and Capstones

Abstract

Problem: Cesarean birth rates for nulliparous, term, singleton, vertex (NTSV) pregnancies in the United States continue to exceed the Healthy People 2030 goal of 23.6%, resulting in preventable maternal and neonatal complications and higher healthcare costs.

Context: This quality improvement (QI) initiative was conducted in a high-acuity labor and delivery unit in California’s Central Valley, an area characterized by maternal health disparities, high rates of comorbidities, and limited access to prenatal care. The goal was to reduce the NTSV cesarean rate to 18.0% by July 31, 2025.

Interventions: Guided by Kotter’s 8-Step Change Theory and the Plan-Do-Study-Act (PDSA) framework, …


Mental Health And Substance Use Interventions Within Muslim Community Spaces: A Community Based-Participatory Research Proposal, Halah Mansour Alayleh Aug 2025

Mental Health And Substance Use Interventions Within Muslim Community Spaces: A Community Based-Participatory Research Proposal, Halah Mansour Alayleh

Master's Projects and Capstones

Background. Muslim Americans face significant mental health and substance use challenges compounded by Islamophobic discrimination, cultural stigma, and barriers to accessing culturally competent services. They also significantly underuse professional mental health services. Purpose. This study aims to collaborate with Muslim communities within the San Francisco Bay Area to develop a replicable intervention framework for addressing mental health and substance use stigma within mosques and other Muslim community spaces. Methods. The proposal uses a community-based participatory research (CBPR) methodology while integrating the theory of planned behavior (TPB) and stigma theory in the framework. This proposal outlines the four phases of intervention …


The Protective Role Of Resilience In Indirect Aggression Perpetration And Victimization, Amelia Klass Aug 2025

The Protective Role Of Resilience In Indirect Aggression Perpetration And Victimization, Amelia Klass

Electronic Theses and Dissertations

This study examines the relationship between resilience and indirect aggression, specifically relational and social aggression, utilizing a sample of 104 females aged 18–22. Indirect aggression, characterized by behaviors such as social exclusion, gossip, and manipulation, is associated with significant emotional and interpersonal difficulties. Using a theoretical basis that includes gender schema theory, social learning theory, and social information processing theory, this study investigates whether resilience has a significant relationship in both the perpetration of and victimization through the use of indirect aggression. Participants completed self-report measures, including the Adult Resilience Measure – Revised and the Young Adult Social Behavior Scales …


Demystifying The Discharge Coefficient For Flow Over Thin Weirs And Sills, Joseph E. Pugh, Subhas Karan Venayagamoorthy, Timothy K. Gates Aug 2025

Demystifying The Discharge Coefficient For Flow Over Thin Weirs And Sills, Joseph E. Pugh, Subhas Karan Venayagamoorthy, Timothy K. Gates

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

A revised derivation of the discharge coefficient for flows over thin weirs and sills in the limits of wall overflow to a free overfall is given. Using dimensional analysis, we show that the discharge coefficient, (Formula presented), in the classical weir-discharge equation is best understood as a weir Froude number, (Formula presented), which accounts for the combined effects of inertia, contraction and viscous energy losses within the flow field. A comprehensive set of experimental data from historical studies is complimented by new data from the authors, featuring both laboratory flume experiments and three-dimensional numerical simulations of weir flows. Synthesis of …


Dual-Function Polyester Nanoparticles For Amplified Anti-Inflammatory Effects, Ingrid M Heyns, Abiodun T Wahab, Raghu Ganugula, David Sheikh-Hamad, M N V Ravi Kumar, Meenakshi Arora Aug 2025

Dual-Function Polyester Nanoparticles For Amplified Anti-Inflammatory Effects, Ingrid M Heyns, Abiodun T Wahab, Raghu Ganugula, David Sheikh-Hamad, M N V Ravi Kumar, Meenakshi Arora

Faculty, Staff and Students Publications

This study investigates a dual-acting drug delivery system using naringenin (NAR) as a folate receptor ligand to enhance intestinal uptake and encapsulated NAR for combating inflammation. The dual-acting systems were tested in vitro on cisplatin-induced human kidney-2 cells and in vivo in a mouse model of cisplatin-induced acute kidney injury (AKI). NAR-loaded passive nanoparticles [P2Ns(NAR)] and dual-acting systems [P2Ns-NAR(NAR)] showed notable advantages over unformulated NAR, reducing the required dose by up to 57 and 79%, respectively. These nanoparticles modulated immune responses, restored T cell function, and shifted macrophage polarization from proinflammatory M1 to tissue-repairing M2. In addition, P2Ns-NAR(NAR) alleviated AKI …


South Atlantic Bank Internship Report, Trevor J. Naun Aug 2025

South Atlantic Bank Internship Report, Trevor J. Naun

Goal 8: Decent Work and Economic Growth

No abstract provided.


Cover And Contents Aug 2025

Cover And Contents

Turkish Journal of Biology

No abstract provided.


Kabasura Kudineer Choornam, A Medicinal Polyherbal Formulation, Modulates Human Macrophage Polarization And Phagocytic Function, Asli Korkmaz, Duygu Ünüvar, Si̇nem Günalp, Derya Göksu Helvaci, Duygu Sağ Aug 2025

Kabasura Kudineer Choornam, A Medicinal Polyherbal Formulation, Modulates Human Macrophage Polarization And Phagocytic Function, Asli Korkmaz, Duygu Ünüvar, Si̇nem Günalp, Derya Göksu Helvaci, Duygu Sağ

Turkish Journal of Biology

Background/aim: Kabasura kudineer choornam (KKC) is a polyherbal formulation of 15 ingredients. It has antiinflammatory and antimicrobial properties and are effective in managing the symptoms of H1N1 swine flu and COVID-19. However, its mechanism of action is not fully understood. In this study, we examined the effect of KKC on the polarization and function of primary human macrophages.

Materials and methods: Human monocyte-derived macrophages (M0 macrophages) pretreated with KKC extract were polarized into M1, M2a, or M2c subtypes. The expression of the M1/M2 polarization markers was analyzed using qPCR, flow cytometry, and ELISA, and the phagocytosis capacity of …


Mir-9-5p Alleviates The Development Of Abdominal Aortic Aneurysm By Regulating The Differentiation Of Cd4+Il-10+T Cells Via Targeting The Crosstalk Between Nrf2 And Nf-Κb Signaling Pathways, Hongfu Liu, Jinyi Zhang, Lubin Li, Benxiang Yu, Chunlei Zhang, Wenqiang Niu, Yawen Cheng, Hengyang Dong, Yukun Zhang, Xinlin Luo, Yanlian Xiong, Yueming Wang Aug 2025

Mir-9-5p Alleviates The Development Of Abdominal Aortic Aneurysm By Regulating The Differentiation Of Cd4+Il-10+T Cells Via Targeting The Crosstalk Between Nrf2 And Nf-Κb Signaling Pathways, Hongfu Liu, Jinyi Zhang, Lubin Li, Benxiang Yu, Chunlei Zhang, Wenqiang Niu, Yawen Cheng, Hengyang Dong, Yukun Zhang, Xinlin Luo, Yanlian Xiong, Yueming Wang

Turkish Journal of Biology

Background: Abdominal aortic aneurysm (AAA), a gradual segmental dilatation of the abdominal aorta, is associated with a high mortality rate. The pathophysiological molecular mechanisms underlying AAA remain unclear. In recent years, changes in miRNA levels have been reported to be involved in the development and treatment of AAA. This study aimed to investigate the potential targets and underlying mechanisms of miR-9-5p in attenuating AAA progression by modulating the inflammatory response.

Materials and methods: Biochemical kits were used to measure the levels of inflammatory factors, antioxidant enzyme activity, and serum oxidative stress in normal and AAA model mice. miR-9-5p overexpression was …


Lactic Acid Bacteria Alleviate Neuronal Excitotoxicity And Extend Caenorhabditis Elegans Lifespan, Bao Le, Thi Nhat Hong Nguyen, Seung-Hwan Yang Aug 2025

Lactic Acid Bacteria Alleviate Neuronal Excitotoxicity And Extend Caenorhabditis Elegans Lifespan, Bao Le, Thi Nhat Hong Nguyen, Seung-Hwan Yang

Turkish Journal of Biology

Aim: Neuronal cell death plays a critical role in the development of neurological disorders associated with aging. This study aimed to evaluate the beneficial effects of heat-killed lactic acid bacteria (hkLAB) on neuroblastoma cells and Caenorhabditis elegans.

Materials and methods: We pretreated heat-killed Lactobacillus fermentum CNU384 (hkCNU384), L. brevis CNU386 (hkCNU386), L. helveticus CNU395 (hkCNU395), and L. paracasei CNU396 (hkCNU396) at a concentration of 109 CFU/mL to investigate their neuroprotective effects on glutamate-induced SH-SY5Y cells and their impact on the lifespan of 6-hydroxydopamine (6-OHDA)-induced C. elegans.

Results: Our findings indicate that hkCNU395 and hkCNU396 protected against glutamate-induced cell death …


Chelidonium Majus L.-Containing Gel May Improve Diabetic Wound Healing By Modulating Mmp-2, Mmp-9, And Collagen Levels, Kaan Kaltalioğlu, Eli̇f Naz Gürsoy, Barbaros Balabanli, Zeki̇ Aytaç, Şule Coşkun Cevher Aug 2025

Chelidonium Majus L.-Containing Gel May Improve Diabetic Wound Healing By Modulating Mmp-2, Mmp-9, And Collagen Levels, Kaan Kaltalioğlu, Eli̇f Naz Gürsoy, Barbaros Balabanli, Zeki̇ Aytaç, Şule Coşkun Cevher

Turkish Journal of Biology

Background/aim: Delayed wound healing in diabetic patients is a significant complication that reduces quality of life, prompting the continuous investigation of new therapeutic agents. This study designed to explore the dose-dependent effects of different parts of Chelidonium majus L. (CM), a medicinal plant traditionally used for skin disorders, on diabetic skin wounds.

Materials and methods: In diabetic rats, full-thickness excisional wounds were formed. CM-containing gels (aerial parts at 3%, 6%, 9% and root at 0.5%, 1%, 1.5%) were developed and applied to the wounds. After the treatment period, the rats were sacrificed, and wound healing activity was assessed macroscopically, histopathologically, …


Cathepsin G As A Mechanistic Driver Of Tumor Growth And Osteolytic Bone Metastasis, Srilaasya Nedunoori, Ridhi Bhola, Reegan Sturgeon, Rakesh K. Singh Aug 2025

Cathepsin G As A Mechanistic Driver Of Tumor Growth And Osteolytic Bone Metastasis, Srilaasya Nedunoori, Ridhi Bhola, Reegan Sturgeon, Rakesh K. Singh

Posters: 2025 Summer Undergraduate Research Program

Breast cancer is one of the leading causes of cancer-related mortality, largely due to its tendency to metastasize to bone. Our lab has demonstrated that tumor-bone interaction is important in this osteolytic bone metastasis mediated by the dysregulation of a unique set of genes. Among these genes, several proteases are up-regulated at the tumor-bone interface, including Cathepsin G, a serine protease, which is primarily secreted by neutrophils. These proteases act as mediators between the tumor and the stroma. Previously, we have shown that malignant cells and osteoclasts at the TB interface express higher levels of Cathepsin G, which is critical …


Development Of Numerical Tools And Performance Metrics For Analysis Of Optical Particle Counters, Doug Webb Aug 2025

Development Of Numerical Tools And Performance Metrics For Analysis Of Optical Particle Counters, Doug Webb

Theses and Dissertations

Monitoring air quality is essential for understanding and mitigating the health impacts of airborne particulate matter (PM), which is linked to respiratory and cardiovascular disease. Optical particle counters (OPCs) are widely used for air quality monitoring, yet their precision and accuracy remain uncertain due to inconsistent performance evaluations. In this thesis, performance metrics are developed that can be used to assess the accuracy of OPCs in measuring PM concentrations and size distributions. Computational fluid dynamics (CFD) simulations are employed to analyze the behavior of particle-laden air streams through representative OPC models. The impact of design parameters is quantified using newly …