Digital Commons Network^™

Investigating The E74-Mediated Regulation Of A Gata Factor In Aedes Aegypti Mosquitoes, Jacklyn Marie Estrada

Open Access Theses & Dissertations

The mosquito species Aedes aegypti has a significant impact on public health as a vector for multiple pathogens. Its ability to transmit deadly diseases, including Yellow Fever, Dengue Fever, and Zika, emphasizes the urgency of understanding its reproductive biology. In female mosquitoes, reproductive success hinges on obtaining a vertebrate blood meal, which triggers vitellogenesis - the synthesis of yolk protein precursors (YPPs) necessary for egg development. Without a blood meal, female Ae. aegypti remain in a state of previtellogenic arrest, where the YPP gene vitellogenin (Vg) is repressed by a type of transcriptional factor, GATAr (AaGATAr) (Attardo et al., 2003). …

Three Essays On Entrepreneurial Orientation And Competitive Repertoire, Gang Fan

Open Access Theses & Dissertations

While scholars confirm the positive relationship between entrepreneurial orientation (EO) and firm performance with meta-analyses, the mixed findings with widespread effect sizes imply that this critical relationship in entrepreneurship literature deserves further inspection. In this three-essay dissertation, I integrate the entrepreneurial orientation literature with the competitive repertoire literature. Specifically, in essay 1, I develop a theoretical framework of EO, competitive repertoire, and firm performance through the lens of capability theory. In the second essay, I examine the moderating role of competitive pressure on the EO-competitive repertoire relationship with a sample of all U.S.-listed firms. Finally, I articulate and examine how …

Restoring Balance: Choctaw Policy And The Environment In New Spain's Eighteenth-Century Frontier, Fior Daliso Garcia Lara

Open Access Theses & Dissertations

During the colonial period, Indigenous peoples in the Lower Mississippi Valley used their deep ecological knowledge to respond to imperial pressures. Eighteenth-century Louisiana was a contested borderland where Spain, France, and England vied for expansion through alliances, warfare, and trade with Native tribes. As European powers vied for control of the region, Native groups devised strategies to assert sovereignty over their territories and livelihoods. My dissertation examines the ecological history of the Choctaw and Spanish Louisiana from 1763 until the United States Indian Removal Act in the 1830s. It argues that imperial disputes over Indigenous lands compelled the Choctaw to …

Cellular And Noncellular Influences On Lipid Nanoparticle Tropism In The Liver, Mario Yomir Mata Corral

Open Access Theses & Dissertations

Hepatocellular carcinoma (HCC) is currently ranked as the second leading cause of cancer-related mortality worldwide, causing more than 700,000 deaths a year. The liver is important in blood filtration and metabolism, and for this reason is a prime target for drug delivery, with lipid nanoparticles (LNPs) showing promise as carriers due to their natural hepatic tropism. However, LNP efficacy is decreased in HCC due to the limited understanding of liver physiology in cancerous environments. This project proposes to address this gap by using a tissue-clearing technique known as CLARITY along with a chemically tagged LNP for comprehensive visualization of LNPs …

Evaluation Of Salt-Free Electrodialysis Metathesis For High Recovery Inland Desalination Brine Management, Tayia Oddonetto

Open Access Theses & Dissertations

Salt-Free Electrodialysis Metathesis (SF-EDM) is an emerging electro-driven membrane technology designed to minimize brine discharge while enabling selective ion separation and resource recovery. This dissertation presents an evaluation of SF-EDM, spanning bench-scale studies with synthetic brine from the Brackish Groundwater National Desalination Research Facility in Alamogordo, NM, real reverse osmosis (RO) brines from the Kay Bailey Hutchinson Desalination Plant in El Paso, TX, and finally a weeklong pilot demonstration at the Yuma Desalting Plant in Yuma, AZ. Bench-scale experiments established process feasibility and performance trends, while pilot results revealed the value of pre-treatment and system configuration. SF-EDM demonstrated high hydraulic …

Aluminum Doped Tin Sulfide Thin Films For Solar Cell Applications, Gabriel Rodriguez Guijarro

Open Access Theses & Dissertations

Tin sulfide (SnS) is theorized to be a suitable material for solar cells, but there are some difficulties that have not been overcome when making thin films that have the properties needed to compete with other materials. This work investigates the structural and optoelectronic properties of aluminum-doped SnS thin films, deposited via magnetron cosputtering physical vapor deposition at different temperatures. To characterize the films a variety of techniques were used: Raman spectroscopy, SEM, TEM, X-Ray Reflectivity, and UV-Vis spectroscopy. The results show that the target stoichiometry is a relevant parameter to take into account when growing SnS thin films, the …

Humboldt County, Dennis Robert Sanchez

Open Access Theses & Dissertations

Danny Marquez, a police sergeant for the Los Angeles Police Department, takes his family on a vacation to Seattle, Washington. On the way, they stop in Humboldt County, and Danny is captivated by the beauty and serenity of this county. He imagines moving his family to Humboldt County and leaving the troubles of big city life behind. He applied for the position of Chief Inspector for the Humboldt Police. By the time he is hired, he loses both his son to Fentanyl and his wife to suicide. He is hired for the position but finds himself alone. He considers suicide. …

A Digital Engineering Framework For Ai-Driven Trade-Off Evaluation And Predictive Component Classification, Alejandro Silva Au

Open Access Theses & Dissertations

This thesis introduces a digital engineering tool designed to help engineers make smarter decisions when choosing actuators. At its core, the system brings together machine learning (specifically XGBoost) and a decision-making method called Multi-Utility Attribute Theory (MUAT). The goal is to support engineers in picking components based on what really matters for their designs, whether that's speed, cost, durability, or any other performance factor. What makes this tool stand out is its user-friendly interface that lets people interact with the system directly. It takes a set of actuator performance data, classifies each one into a relevant use category, and then …

Exploring The Landscape Of Collective Leadership Practice In Rural Nebraska: A Qualitative Sequential Multimethod Study, Haden Myles Botkin

Department of Agricultural Leadership, Education, and Communication: Dissertations, Theses, and Student Research

Rural communities across Nebraska face a myriad of complex challenges that cannot be solved by individual, heroic leaders. As such, collective leadership has begun to emerge in these communities as actors coalesce around local issues. However, little is known about collective leadership practice and development in rural contexts, resulting in a theory-to-practice gap. To that end, this qualitative sequential multimethod study sought to explore how rural community leaders and community development educators perceive, describe, and make meaning of collective leadership practices in rural Nebraska. Three phases comprise this study.

Phase I, the QUAL phase, was guided by the question, How …

Beyond The Bananas: Grief, Grace, & The Groove, Abby L. Asher

Research Papers

The term 'participatory documentary' was first coined by Bill Nichols, a documentary theorist. He describes it as a mode of documentary where the observer interacts with the observed, and the filmmaker becomes a subject of the film. What started as a little documentary about a minor league baseball team's line dance group composed of women over the age of 65, shifted when tragedy hit the 'observer'. It turned out these ladies were now in the right place at the right time to help guide the documentary maker out of her grief. What resulted was a new documentary with a participatory …

Comparative Analysis And Future Trends Of Friction And Regenerative Braking Systems, Madhukar Reddy Janga

Research Papers

The Research provides a full-scale analysis of traditional friction braked systems together with regenerative braking systems with focus on their working methods along with contemporary integration practices and forthcoming technological developments. Friction braking which has been widely used since long ago provides necessary dependable slowing abilities yet leads to substantial heat generation together with the release of harmful particles. Regenative braking systems that power electric and hybrid vehicles retrace vehicle momentum during braking to create stored electrical energy which results in better fuel economy with lower environmental effect. The research performs an in-depth analysis of braking system operational mechanics through …

Broadband Resilience By Zero Trust Community Network Policy Design, Lee W. Mcknight, Danielle Smith

The Lender Center for Social Justice

This paper proposes a Zero Trust framework for broadband policy design to enhance community network resilience. It provides a governance and policy perspective for ensuring secure, equitable broadband access.

Extended Program Notes For A Viola Graduate Recital, Maria Del Mar Anasco Mina

Research Papers

María del Mar Añasco Mina, for the Master of Music degree in Performance, presented on April 10, 2025, at Southern Illinois University Carbondale.

TITLE: EXTENDED PROGRAMS NOTES FOR A VIOLA GRADUATE RECITAL MAJOR PROFESSOR: Dr. Rossana Cauti.

This research paper is an expanded version of the program notes for the author’s viola graduate recital on December 8, 2024, at the Old Baptist Foundation in Carbondale, Illinois. The paper includes two works originally written for the instrument and two adapted. With Dr. Rossana Cauti’s help, the author chose four works to prepare a viola graduate recital, including works from different countries …

Roles Of Three Conserved Active Site Residues Of Cytochrome C Nitrite Reductases During The Early Steps Of Nitrite Reduction, Shahama Alam, Bradley J. Dimock, Brian Bennett, Steven J. Reinhardt, Shahid Shahid, A. Andrew Pacheco, Jarett Wilcoxen

Physics Faculty Research and Publications

Cytochrome c nitrite reductases (ccNiRs) catalyze reduction of nitrite to ammonium in a six-electron, eight-proton process. This report explores how the behavior of three active site ccNiR variants differs from that of the wild type enzyme (ccNiR_wt) in the presence of nitrite and a variety of electron donors. While the nitrite-loaded active site of Shewanella oneidensis ccNiR_wt could be 2-electron reduced within seconds to yield a 6-coordinate ferrous nitrosyl ({Fe(L)NO}⁷) at high applied potentials, quantitative reduction of the nitrite-loaded variants R103Q, H257Q, or Y206F required substantially stronger reductants and yielded a different product over several …

Addressing Jail Recidivism Among Inmates With Substance Use Disorders Through Treatment Interventions: A Scoping Review, Rosa C. Contreras

Electronic Theses, Projects, and Dissertations

This project studies effective treatments for formerly incarcerated individuals with substance use disorders (SUD’s) who become homeless. This study examines evidence-based, non-pharmaceutical interventions identified in current research, analyzing their effectiveness in addressing key social issues. It explores how these interventions contribute to improving outcomes for individuals and communities, particularly in areas such as mental health, addiction recovery, and rehabilitation. Additionally, the study assesses their significance within the field of social work, emphasizing their role in shaping policies, informing best practices, and fostering more holistic, client-centered approaches to care. The potential impact of these interventions is considered in relation to reducing …

The Lived Experiences Of Navajo Nurses During The Covid-19 Pandemic, Stephnie Ann Leeson

Electronic Theses and Dissertations

When COVID-19 was diagnosed on the Navajo Nation, the impact on the people and the healthcare system was not understood. For almost three years, Navajo healthcare workers battled what was known to the Navajo as Dikos Nitsaaígíí Náhást’éíts’áadah, translated as The Big Cough. The Navajo Nation President, Jonathan Nez, referred to it as a Monster, as did many people in the Navajo Nation. Navajo nurses on the frontlines battled the monster daily as they saw friends and relatives succumb to the insidious disease. Much has been written about nurses off the reservations working on the frontline during the pandemic. However, …

Antibacterial Effect Of Ethanol Extracts Of Murraya Paniculata Leaves, Smallanthus Sonchifolius Leaves, Apis Trigona Honey, And Their Combination Against Staphylococcus Epidermidis, Sri Agung Fitri Kusuma, Irma Erika Herawati, Felika Nugrahaningtiyas

Chimica et Natura Acta

Several studies have reported that combining plant extracts may enhance their efficacy against specific bacterial infections. This study aimed to analyze the antibacterial interaction of ethanol extracts of Murraya paniculata leaves, Smallanthus sonchifolius leaves, Apis trigona honey, and their combinations against Staphylococcus epidermidis ATCC 12228, as each component has shown individual antibacterial activity against this bacterium. The antibacterial interactions of the test materials, both individually and in combination, were evaluated using the agar diffusion method with clindamycin phosphate as the standard antibiotic. The minimum inhibitory concentration (MIC) of the most potent extract was determined through the microdilution method according to …

Effect Of Fermentation On The Phsyco And Functional Properties Of Red Sorghum Flour (Sorghum Bicolor L.), Elazmanawati Lembong, Endah Wulandari, Putri Widyanti Harlina, Syifa Tsalitsu

Chimica et Natura Acta

Modification of red sorghum flour by fermentation method can improve the physical, chemical, and functional properties of the resulting sorghum flour. The purpose of this study was to determine the fermentation time that can affect the physical and functional characteristics of red sorghum flour fermented spontaneous (TSS) and non-spontaneous (TTS). Results indicated that the best treatment was red sorghum flour fermented at 24 hours both spontaneous and non-spontaneous. TSS at 24 hours had a water absorption capacity of 1.04%, oil binding capacity of 1.04%, swelling volume of 7.47%, solubility of 7.57%, initial gelatinization temperature of 76.56oC, peak viscosity of 2855 …

In-Silico Of Vascular Endothelial Growth Factor Receptor-2 (Vegfr-2) Inhibitors Of Seven Bioactive Compounds From Sonneratia Alba, Madyawati Latief, Fitria Melani, Yusnaidar Yusnaidar, Indra Lasmana Tarigan

Chimica et Natura Acta

Cancer is a disorder resulting from genetic changes, abnormal growth, and spread to other parts of the body. Cancer treatment is commonly administered through chemotherapy, which often results in adverse side effects. Therefore, research is essential to identify safer alternative cancer therapies. This study aims to identify potential bioactive compound ligand receptor targets from Sonneratia alba as anticancer candidates in silico by identifying VEGFR target proteins based on their pharmacophores and studying their interactions through the reverse docking method. Docking simulations between the native ligand (Tivozanib) and the receptor yielded promising results, with a free energy value of -12.76 kcal/mol …

The Effect Of Different Synthesis Solvents And Dialysis Processes On The Optical Properties Of Carbon Dots From Spent Coffee Grounds Using The Solvotermal Method, Wahyuni Eka Putri, Ahmad Sjahriza, Sri Sugiarti

Chimica et Natura Acta

The distinctive optical properties of carbon dot (CD) make CD is one of the most widely developed carbon nanomaterials today. CD can be synthesized from materials that high in carbon content, such as spent coffee grounds. The optical properties of synthesized CD are influenced by several factors, including the solvent used to synthesize it and the purification method. The purification process that can be done is dialysis. However, this technique is not always used in several researches to purify CD. This study aims to synthesize CD from spent coffee grounds through solvothermal methods with three different solvents, which are water, …

Synthesis Of 1,2-Di(Phenyl)Ethan-1,2-Dione Through Oxidation Of 2-Hydroxy-1,2-Dipheniletanone By Using Copper(Ii) Citrate, Winda Seviani, Arif Fadlan, Vania Wirastuti

Chimica et Natura Acta

1,2-Di(phenyl)-1,2-dione widely used in chemical and pharmaceutical industries and found as a framework in secondary metabolites can be obtained through oxidation of 2-hydroxy-1,2-diphenylethanone using strong acids, homogeneous, heterogeneous, and metal catalysts. However, these oxidation methods exhibit various drawbacks. This study reported the oxidation of 2-hydroxy-1,2-diphenylethanone by using copper(II) citrate to produce 1,2-di(phenyl)-1,2-dione. The oxidation performed with copper(II) citrate and ammonium nitrate in glacial acetic acid as solvent yielded 1,2-di(phenyl)-1,2-dione in 88% yield higher than the nitric acid method (79% yield). The FTIR, NMR spectriscopies, and mass analysis confirmed the structure of 1,2-di(phenyl)ethane-1,2-dione. The oxidation of 2-hydroxy-1,2-diphenylethanone using copper(II) citrate is …

Cytotoxicity Of Chromanone Acid From The Steam Bark Of Calophyllum Incrassatum Against P-388 Leukemia Murine Cells, Ulfatun Hasanah, Robi’Atul Andawiyah, Barrotut Taqiyah, Ratih Dewi Saputri, Tjitjik Srie Tjahtjandarie

Chimica et Natura Acta

Calophyllum incrassatum is one of the plant species of the Calophylloceae family and is found endemic in Kalimantan and Sumatra. This study aims to isolate chromanone acid compounds from the stem bark of C. incrassatum and determine the relationship between structure and activity against murine Leukemia P-388 cells. The extraction method used was maceration using methanol solvent, partitioned with n-hexane and ethyl acetate solvents. Separation and purification of n-hexane and ethyl acetate extracts by vacuum liquid chromatography, pressed column, and radial. Two chromanone acids derivatives, isoapetalic acid (1), and methyl isoapetalic (2), have been successfully isolated from the stem bark …

Lesbian, Gay, Bisexual, Transgender, Gender Expansive, And Queer+ Client Experiences Discussing Consensual Nonmonogamy In Therapy: An Interpretive Phenomenological Analysis, Evan Wendell Engle-Newman

Dissertations

This dissertation presents the findings from an Interpretive Phenomenological Analysis (IPA) study on how lesbian, gay, bisexual, transgender, gender expansive, and queer+ (LGBTGEQ+) clients experience discussing consensual nonmonogamy (CNM) in therapy. This study explored how five individuals made meaning of their experiences discussing CNM with current or prior therapists. The meaning they made of these experiences were situated in the context of social and cultural factors that influenced their discussions of CNM in therapy.

There were three research questions for this study including one primary question and two guiding sub-questions. The primary question was: what are the experiences of LGBTGEQ+ …

Investigating Undergraduate Students’ Statistical Literacy In Media Contexts, Samuel Waters

Dissertations

As the uses of data in society continue to expand, it is vital to prepare students to engage with data in meaningful and critical ways. Undergraduate introductory statistics courses provide an opportunity for students to develop important knowledge and skills for interpreting and questioning statistical information in social contexts. The purpose of this convergent mixed methods study was to use quantitative assessment data and qualitative interview data to investigate the statistical literacy of students in an undergraduate introductory statistics course in media contexts. This study defined statistical literacy using Watson and Callingham’s (2003) six-level construct. Specifically, this study investigated students’ …

From Foster Care To College Graduation: A Qualitative Study Of The Experiences Of College Graduates Who Aged Out Of Foster Care, Antonia Irene Thomas

Dissertations

Students who have spent time in the foster care system encounter a myriad of barriers and challenges to academic success. Among these challenges is attending post-secondary school and completing a college degree. High school academic performance, knowledge of the college application process, and lack of financial support are some factors that act as barriers to post-secondary attendance. Lack of support and difficulty navigating the college experience can negatively impact the ability to complete college. Even in instances of desire and academic ability to attend college, many of these students never attend, or do not complete and obtain a degree. Between …

Revealing The Impacts Of Teachers’ Lived Experiences With Burnout: An Educational Criticism Study, Joanna Laurx

Dissertations

The purpose of this educational criticism study is to describe the experiences of burnout for four teachers in a western state school district. To represent and illustrate these experiences, Eisner’s methodology, educational connoisseurship and criticism, was utilized. Three research questions guided this study; How do teachers describe experiences of burnout?; How do teachers describe the impact of curriculum on burnout?; How do teachers perceive burnout impacts their instruction and interactions with students? Data for this study was collected on the four participants through a one-on-one interview, two focus groups, two classroom observations, and artifacts and analyzed using emotions and values …

Beliefs Of California And Colorado Parents, School Professionals, And School Administrators Around Providing Comprehensive Sexuality Education To School-Aged Youth With Intellectual And Developmental Disabilities, Michelle Aleen Kalos

Dissertations

People with intellectual and developmental disabilities (IDD) are victims of sexual assault at a rate seven times higher than people without IDD (Shapiro, 2018a). “One of the best ways to stop sexual assault is to give people with intellectual disabilities the ability to identify abuse and to know how to develop the healthy relationships they want” (Shapiro, 2018b, p. 1). Comprehensive sexuality education (CSE) could be a scientifically accurate, evidence-based, age-appropriate, culturally relevant, and inclusive educational experience for youth with IDD (Koch et al., 2024). However, only around 16% of students with IDD were likely to receive sex education in …

Sensitivity Analysis Of Flexible Pavement For South Carolina Conditions, Shilpa Girish

All Dissertations

The objective of the study was to evaluate the sensitivity of various input variables on the flexible pavement design thickness of high-speed, high-traffic routes in South Carolina using the Mechanistic-Empirical Pavement Design Guide (MEPDG) by means of the AASHTOWare Pavement ME Design software using global calibration coefficients with a focus on bottom-up fatigue cracking. The variables considered in this investigation included two-way average annual daily truck traffic (AADTT), asphalt mix type, climate station, subgrade type and resilient modulus, and aggregate base thickness. The study includes comparative analysis using older methods like the AASHTO 1993 method and the South Carolina DOT …

Radiation Induced Vaporization Of Exoskeletal Droplets As Potential X-Ray Acoustic Contrast Agents, Mohamed E. Eldib, William N. Frantz, Mark A. Borden, Ryan Lanning, Moyed Miften, David H. Thomas

Department of Radiation Oncology Faculty Papers

BACKGROUND: In vivo dosimetry is a crucial component of ensuring accurate and safe radiation therapy (RT) delivery, but many existing techniques face challenges such as low signal-to-noise ratio (SNR), which can limit their clinical applicability.

PURPOSE: In this study, we investigate a novel contrast agent sensitive to megavoltage (MV) radiation in vitro, ultimately aiming for in vivo dosimetry.

METHODS: Vaporizable exoskeletal droplets were engineered to phase-change into ultrasound-responsive microbubbles upon exposure to MV photon radiation. These droplets comprised a hydrocarbon (HC) exoskeleton doped with gold nanoparticles (GNPs) surrounding a liquid fluorocarbon (FC) core. Radiation absorbed by the GNPs induced localized …

(Wp 2025-04) Individual And Collective Behavior, John B. Davis

Economics Working Papers

Compares the mainstream and Institutional and evolutionary economics views of individual and collective behavior. Describes the methodological assumptions for each. Distinguishes the two opposed approaches conceptions of time they employ. Explains the role social identity applies in explaining two opposed approaches adopt different conceptions of time. Closes with an explanatory dilemma the subject creates.