Digital Commons Network^™

Harmful Effects Of The Interaction Between Microplastic Container, Aluminuim Foil And Hot Water On Some Physiological Parameters Using Pigeon Model, Faten S Mounce, Nadheerah F Neamah, Manal N Alhayder

Baghdad Science Journal

Due to common used of disposable food containers cuurrently.This study evaluated the toxicity resulted from the interaction between the boiling tap water, microplastic container , aluminuim foil with or without microwave radiation on some physiological and histological parameters in Pigeons. Forty pigeons were classified into four groups. The birds in group 1 drink tap water without boiling placed in the usual drinking bowl. The birds in group 2 received tap water in thermoplastics containers previously boiled in microwave oven for 5 minutes, whereas in group3, the birds drink boiled tap water that put in thermoplastics containers for 5 min and …

Synthesis, Biological Activity And Molecular Docking Study Of Some New Chalcones, 5,6-Dihydropyrimidin-2-Ol And 5,6-Dihydropyrimidin-2-Thiol Derivatives Bearing 1,2,3- Triazoline, Hayder Raheem Ali, Ahmed Wahed Naser

Baghdad Science Journal

Many new chemicals, including chalcones, derivatives of 5,6-dihydropyrimidin-2-ol and 5,6-dihydropyrimidin-2-thiol, are synthesized in this work. The starting materials are substituted acetophenone derivatives involving 1,2,3-triazoline (1). Chalcone derivatives (2a-h) were obtained by condensing compound (1) with some substituted aromatic aldehydes in the presence of 40% potassium hydroxide KOH. The process of producing pyrimidin-2-ol derivatives (3a–e) by cyclizing produced chalcone derivatives (2a–e) urea in the presence of sodium hydroxide. Equivalent pyrimidin-2-thiol derivatives (4a-d) were produced when chalcone derivatives (2a-d) reacted with thiourea in the presence of sodium hydroxide. The …

Synthesis, Characterization, And Anticancer Evaluation Of Novel Nickel(Ii) And Copper(Ii) Complexes Derived From Isatin Thiosemicarbazones, Shahnaz Abdulhamid Hamad

Baghdad Science Journal

The complex of (2,2'-(7,7'-dimethyl-2,2'-dioxo-1,1',2,2'-tetrahydro-3H,3'H-5,5'-biindole-3,3'-diylidene) dihydrazinecarbo thioamide), denoted as L, was prepared by the reaction of o-tolidine with chloral hydrate and hydroxylamine hydrochloride in the presence of sodium sulfate and a co-solvent, absolute ethanol. The novel complexes of Ni(II) and Cu(II) with the ligand, L, have been synthesized from a reaction of one mole of L with two moles of NiCl₂ and CuCl₂ to produce complexes with the general formula [M₂LCl₂] [where M= Ni(II) or Cu(II)]. All three complexes are novel and have a square planar geometry. The metal ions in the two metal complexes …

Hydrothermal Synthesis Of High Surface Area Mesoporous Silica As An Efficient Adsorbent For Removal Of Crystal Violet Dye From Aqueous Solution, Inaam H. Ali, Ameera Hassan Hamed, Ennas Abdul Hussein, Saadiyah A. Dhahir

Baghdad Science Journal

In this work, a sample of mesoporous silica (MPS) with a high surface area was prepared by hydrothermal synthesis procedure. To investigate the properties of the prepared sample, it was characterized using different techniques like N₂ Adsorption-desorption, Scanning electron microscopy (SEM), X-ray diffraction (XRD) and Atomic Force microscopy (AFM). In order to evaluate the efficiency of the prepared MPS, adsorption study was carried to examine the ability of MPS to remove crystal violet dye (CV) from aqueous solution. The study was done in different conditions of initial concentration (25-60 mg/L) of dye, dosage of MPS (0.01-0.05 g) and temperature …

Genetic Analysis Of Spp1 Polymorphism In Samples Of Iraqi Colon Cancer Patients, Ghufran Kadhim Talal, Ahmed Younus Abed

Baghdad Science Journal

Cancer is a multistage defect and very complex disease. It is distinguished by particular genetic mutations that lead to a loss of management of cellular functions during uncontrolled growth of normal cells leading to malignant cells. CA18 occurs by the abnormal growth of cells in colon. SPP1 is multifunctional protein. The aim of this study is to study genetic polymorphism of SPP1gene in CA18 patients along with healthy individuals to find the relationship with CA18 and compare both globally. DNA was extracted and the genetic polymorphism of the SPP1gene was determined. Genetic analysis of SPP1 (in rs11730582 T/C region) polymorphism …

A Study Of Wear Measurement And Life Prediction Of Insert Chute Liner On Gold Ore Processing, Ferry Ardika Natanael, Nony Maulidya, Dedi Priadi

Journal of Materials Exploration and Findings

Chutes are critical materials handling assets to transport solid particles from one process step to another in mineral processing, coal mining and cement industries. The material transport, because of material characteristics, cause severe wear on internal lining of chutes or bins’ structure. The wear problem on internal lining of bins or chutes needs to be checked to keep production efficiency. Therefore, not checked wear rate causes liner replacement schedule becomes unpredictable. It leads to production loss and highly cost maintenance in industry. This study shows that condition-based maintenance through regular thickness measurement using Ultrasonic Transducer (UT) to predict life service …

Experiencing Race, Racism And Racialization In Transnational Contexts: Racial Literacies Of First-Year International Asian Students., Nasiba Norova

Graduate Doctoral Dissertations

This research focused on exploring the racial literacies of first-year international East Asian (EA) students, specifically examining their perceptions of and experiences with race, racism, and racialized groups in various social and educational contexts in both their home countries and the United States. The study used critical ethnography to examine the perspectives of EA international students and composition faculty. It involved multiple semi-structured interviews, journal entries, racial literacy autobiographies, site document analysis, and class observations to understand how students perceived exposure to race, racism, and racialized groups and how faculty viewed the importance of racial education for international students in …

Analysis Of Leak Testing Planning For Carbon Dioxide Piping Systems In The Development Of Carbon Capture, Utilization, And Storage Facilities In The Bintuni Basin, Devi Sentiani, Akhmad Herman Yuwono Professor

Journal of Materials Exploration and Findings

Carbon Capture, Utilization, and Storage (CCUS) technologies have become a key strategic response to global efforts to reduce CO₂ emissions. This study presents a leak testing strategy designed for a carbon dioxide (CO₂) piping system as part of a Carbon Capture, Utilization, and Storage (CCUS) project in the Bintuni Basin, West Papua, Indonesia. This study aims to ensure the system is properly prepared before commissioning by designing a leak test plan that is both practical and technical, based on ASME B31.3, ASME PCC-2, and API STD 520 Part 1. We conducted the process, which involves identifying the system boundaries, …

Preparing For The Habitable Worlds Observatory: Spectropolarimetric Radiative Transfer Models Of Terrestrial (Exo)Planets, Kenneth E. Goodis Gordon

Graduate Thesis and Dissertation post-2024

The next major step for the exoplanet community lies in the characterization of terrestrial exoplanets, especially when it comes to identifying biosignatures and determining the habitability of these worlds. In response to this, NASA has proposed the Habitable Worlds Observatory (HWO), with the primary goal of searching for and characterizing Earth-sized planets in the habitable zones (HZ) of their stars. However, current characterization strategies that only rely on the unpolarized flux from the planets lose some of the informational content of the observed light and therefore suffer from degeneracies in the calculated planetary parameters. The sensitivity of polarization to the …

Pride Or Prejudice: An Examination Of Queer Content In Florida High Schools, Niamh L. Harrop

Graduate Thesis and Dissertation post-2024

This thesis explores how queer individuals reflect on the presence—or more often, the absence—of queer content in their high school education. Despite increasing visibility of LGBTQ+ people in popular culture and legal reform, formal educational spaces remain largely heteronormative and cisnormative structured from a heterosexual and cisgender standpoint. Through a critical qualitative approach, this study draws on semi-structured interviews with 13 queer participants who attended high school in Florida in the years between the legalization of same-sex marriage in 2015 and the passage of Florida’s H.B. 1557 (“Don’t Say Gay” law) in 2022. Using thematic analysis, four key themes were …

Effectiveness Of Leadership Rounding In Reducing Patient-Related Falls In A Medical-Surgical Unit, Elsie-Solange Mvoueng Nkoi-Mimba

Walden Dissertations and Doctoral Studies

Summary In this Doctor of Nursing Practice (DNP) project, I evaluated whether the project site organization’s implementation of leadership rounding reduced patient falls within a medical-surgical unit. Despite established fall prevention strategies, the unit continued to experience ongoing incidents, prompting the implementation of structured leadership rounding. The practice-focused question assessed changes in fall rates over a 3-month postintervention period compared to the preceding 3 months. A retrospective chart review was conducted from December 2023 to June 2024, excluding March 2024 due to partial implementation. I used descriptive statistics to analyze trends. The average monthly fall rate remained stable at 2.67 …

What Are The Predictors Of Malignancy In Inflammatory Bowel Disease?, Zülal İstemi̇han, Bi̇lger Çavuş, Ali̇ Emre Bardak, Ayşe Merve Kirkoğlu, Cansu Kiziltaş, Rüveyda Si̇lay, İbrahi̇m Volkan Şenkal, Zi̇ya İmanov, Kenan Nuri̇yev, Aynure Rüstemzade, Sezen Genç, Mi̇ne Güllüoğlu, Asli Çi̇fci̇başi Örmeci̇, Kadi̇r Demi̇r, Fati̇h Beşişik, Sabahatti̇n Kaymakoğlu, Fi̇li̇z Akyüz

Turkish Journal of Medical Sciences

Background/aimː This study aims to investigate the prevalence of malignancy in patients with inflammatory bowel disease (IBD) followed up in a tertiary reference center.

Materials and methodsː IBD patients with at least 6 months of follow-up from the gastroenterology clinic between 2000 and 2022 wereevaluated retrospectively in a tertiary center. Patient information was obtained from the patient registration system.

Resultsː There were 697 patients in the study, 320 (45.9%) of these were female. The mean age of the patients at IBD diagnosis was 33.4± 13.1 years. The mean follow-up time was 93.1 ± 64.8 (median 84, IQR (25–75) (36–144)) months. …

Different Local Anesthetic Volumes In Pericapsular Nerve Group Block For Hip Fracture Patients, Yusuf Özgüner, Savaş Altinsoy, Gökçen Kültüroğlu, Sevda Gökçe Gürpinar, Derya Özkan, Jüli̇de Ergi̇l, Erbi̇l Aydin

Turkish Journal of Medical Sciences

Background/aim: The pericapsular nerve group (PENG) block is an effective method for pain management in patients with hip fractures. In our study, we compared three different local anesthetic volumes of the PENG block in patients who underwent surgery for hip fracture.Materials and methodsː Patients who underwent surgery with spinal anesthesia for intertrochanteric femur fractures (60 patients) were divided into three groups based on the volume of local anesthetic administered: Group 1 (20 mL), Group 2 (30 mL), and Group 3 (40 mL). Postoperative patient-controlled analgesia was initiated. Postoperative tramadol consumption, rest and movement pain scores, and the duration of motor …

Factors Affecting Extremity Fracture Risk In Children With Attention Deficit Hyperactivity Disorder, Yüksel Sümeyra Naralan, Esra Demi̇rel

Turkish Journal of Medical Sciences

Background/aim: Attention-Deficit/Hyperactivity Disorder (ADHD) is increasingly recognized not only for its behavioural and cognitive challenges but also for its potential implications in physical health, particularly injury risk. This study aimed to investigate the incidence of extremity fractures among children and adolescents diagnosed with ADHD and to evaluate the influence of demographic, clinical, and pharmacological variables—including ADHD subtypes and medication types—on fracture risk

Materials and Methods: This retrospective cross-sectional study included 754 children and adolescents aged 6–18 years who were diagnosed with ADHD according to DSM-5 criteria. Data were collected from electronic health records at a tertiary referral hospital. Variables …

Blood Group Profile Of Türkiye With Regional And Demographic Differences: A 23-Year Retrospective Study, Levent Sağdur, Azi̇z Karaca, Mustafa Nuri̇ Günçikan, Mustafa Yilmaz, Kerem Kinik

Turkish Journal of Medical Sciences

Background/aim: This study aims to comprehensively analyze the distribution of ABO and Rh blood groups, as well as demographic characteristics and regional variations, using data from 9.5 million blood donors across Türkiye.

Materials and methods: In this multicenter, retrospective, cross-sectional study, data were collected from 9,587,592 healthy, voluntary donors who donated to the Turkish Red Crescent between 1998 and 2021. Donors met the criteria of being 18–70 years old, weighing over 50 kg, with hemoglobin levels above 13.5 g/dL for male and 12.5 g/dL for female. The data were evaluated based on age, gender, education level, and geographic region.

Results: …

Evaluation Of Teachers' Knowledge And Awareness About Autism Spectrum Disorder, Hami̇t Harun Bağci, Abi̇de Aksungur, Gülsüm Öztürk Emi̇ral, Erhan Şi̇mşek

Turkish Journal of Medical Sciences

Background/aim: Teachers play an essential role in the early identification of autism spectrum disorder (ASD) and associated difficulties in children. Increasing teachers’ knowledge of ASD can be helpful in identifying these children and making the necessary referrals. This study aimed to assess teachers’ knowledge and awareness of ASD and the factors affecting them.

Materials and methods: This is a cross-sectional study conducted among school counsellors. A total of 171 school counsellors were contacted; school visits were arranged by prior appointment, and the purpose of the study was explained. Data were collected using a questionnaire prepared by the researchers and the …

Comparison Of Novel Diard-Hbv Dna Qpcr Kit With The Artus Hbv Qs-Rgq Kit For Quantification Of Hbv Dna In Clinical Samples, Ülker Çuhaci, Hande Toptan, Bengül Durmaz, Mehmet Köroğlu, Riza Durmaz

Turkish Journal of Medical Sciences

Background/aim: Hepatitis B virus (HBV) leads to widespread chronic infections that may result in long-term complications such as cirrhosis and hepatocellular carcinoma. The use of sensitive molecular methods for HBV DNA quantitation has provided significant contributions for diagnosis and monitoring of disease. The current study aimed to evaluate the diagnostic performances of a novel DiaRD HBV qPCR kit (novel kit) in comparison with the artus HBV QS-RGQ kit (comparator kit).

Materials and methods: A total of 288 plasma samples—105 HBV DNA-positive and 183 HBV DNA-negative—were tested using both kits. The diagnostic and quantitative results of the novel kit were compared …

The Benefits Of Establishing Attending Behavior Prior To The Discriminative Stimulus During Discrete-Trial Instruction: A Systematic Review, Ruben S. Pereira

Seton Hall University Dissertations and Theses (ETDs)

Discrete trial instruction (DTI) is one of the most effective and commonly used instructional strategies for teaching individuals with autism. Researchers and professionals have informally promoted the importance of establishing attending behavior prior to initiating discrete trials. However, some researchers have reported a lack of literature analyzing the effects of establishing attending behavior, prior to instruction, on skill acquisition. Therefore, the benefits of establishing attending as part of DTI remain unknown. The goal of the current thesis was to conduct a systematic review using PRISMA guidelines to search for published studies where attending behavior was a primary independent variable within …

Synthesis, Characterization, Biological Activity And Antioxidant Studies Of New Metal Ion Complexes Based On (E)-4-((Benzo[D]Thiazol-2-Ylimino)Methyl)-1,5-Dimethyl-2-Phenylpyrazolidin-3-One, Rafah Saad Talib, Naser Shaalan

Baghdad Science Journal

The study involved synthesis of four new complexes involving bidentate ligand [(E)-4-((benzo[d]thiazol-2-ylimino) methyl)-1,5-dimethyl-2-phenylpyrazolidin-3-one] with the general formula [M(L)₂Cl₂].xH₂O or [MLCl₂]. xH₂O, where M represents Mn²⁺, Co²⁺, Ni²⁺ and Cu²⁺. The ligand was synthesized by treating the 4-Antipyrinecarboxaldehyde and 2-aminobenzothiazoles in an alcoholic solution. The structural characteristics of ligand and complexes were characterized quantitatively and qualitatively by using various techniques including elemental analyses, magnetic susceptibility measurement, molar conductivity, infrared, ultraviolet absorption, Gc-Mass, and ¹H-NMR spectroscopy studies. The physical measurements indicated that the prepared …

Randomised, Placebo-Controlled Trial Of Oral Hymecromone In Adults With Pulmonary Hypertension, Kathryn Czepiel, Nadine Nagy, Tamera Panjalingam, Anissa Kalinowski, Adam R Frymoyer, Harry Karmouty-Quintana, Bo Gu, Haley Hedlin, Gernot Kaber, Sylvie Dobrota Lai, Joelle I Rosser, Paul L Bollyky, Vinicio De Jesus Perez, Roham T Zamanian

Faculty, Staff and Student Publications

Background: Pulmonary hypertension (PH) is a progressive cardiopulmonary condition associated with increased morbidity and mortality. The extracellular matrix component hyaluronan (HA) is linked to vascular remodelling and interstitial fibrosis in PH. We hypothesised that inhibition of HA synthesis with hymecromone could serve as a reverse-remodelling therapy in PH.

Methods: We performed a proof-of-concept phase IIa randomised, double-blind, placebo-controlled study in adults with pulmonary arterial hypertension and PH associated with interstitial lung disease (PH-ILD). Patients were randomised to a 5:3 ratio and stratified by PH group to receive oral hymecromone or placebo two times per day over 24 weeks. The primary …

Skin-To-Skin Contact At Birth For Very Preterm Infants And Symptoms Of Depression And Anxiety In Parents During The First Year – A Secondary Outcome Of A Randomized Clinical Trial, Siri Lilliesköld, Karoline Lode-Kolz, Björn Westrup, Nils Bergman, Kimmo Sorjonen, Ulrika Ådén, Evalotte Mörelius, Siren Rettedal, Wibke Jonas

Research outputs 2022 to 2026

Background: Mental health issues are common in parents to preterm infants. In the neonatal intensive care unit (NICU), skin-to-skin contact (SSC) as an avenue for parent-infant closeness may improve parental mental health. Few studies exist regarding its benefits when initiated immediately postbirth. The aim was to determine the effect of SSC for very preterm infants at birth on parents' mental health, by assessing symptoms of depression and anxiety within the first year. Methods: The Immediate Parent-Infant Skin-to-Skin Study was a randomized clinical trial conducted 2018–2021 at three NICUs in Sweden and Norway. Very preterm infants (28–33 weeks of gestation) were …

Collapse Of A Quantum Vortex In An Attractive Two-Dimensional Bose Gas, Sambit Banerjee, Kai Zhou, Shiva Kant Tiwari, Hikaru Tamura, Rongjie Li, Panayotis Kevrekidis, Simeon I. Mistakidis, Valentin Walther, Chen Lung Hung

Physics Faculty Research & Creative Works

We experimentally and numerically study the collapse dynamics of a quantum vortex in a two-dimensional atomic superfluid following a fast interaction ramp from repulsion to attraction. We find the conditions and timescales for a superfluid vortex to radially converge into a quasi-stationary density profile, demonstrating the spontaneous formation of a vortex soliton like structure in an atomic Bose gas. We record an emergent self-similar dynamic caused by an azimuthal modulational instability, which amplifies initial density perturbations and leads to the eventual splitting of a solitonic ring profile or direct fragmentation of a superfluid into disordered, but roughly circular arrays of …

Exploration Of Language And Identities Among Study Abroad Participants In Non-Anglophone Context: Experience Of Asian International Students Studying Abroad In Belgium, Long Yat Ding

Journal of Comparative & International Higher Education

This Research Summary examines the study abroad experiences of Asian international students who study in non-anglophone Belgium. This research investigates how the experiences of mobility programme participants impact individual identity, with a focus on national, regional, and global citizenship identity. Eighteen qualitative in-depth semi-structured interviews were implemented. Mixed lived experiences and reactions towards national, regional and global identity after participation in mobility programmes were identified. Findings showcase non-anglophone European Higher Education and the study abroad experience of non-anglophone speakers from Asia in the post-COVID-19 era. The Research Summary provides a critical snapshot of Asian International students’ lived experience, especially under …

What Is Lost When Time Is Saved: Drawing In Collaboration With The Urban Periphery, Carmen Ribaudo

MFA in Visual Art

I pay attention to the overlooked spaces where land and industry meet, prompting me to wonder what can be gleaned in the oily and cracked urban periphery. With a focus on my hometown St. Louis, this industrial city is my subject matter. And so, I draw in a neighborhood bisected by a highway. I animate with sand near the river confluence on land preserved after a historic flood. I make my own bricks in this Brick City, setting up in locations of former terra cotta clay mines. I sit in the tension of what author Michael Martone calls the “midwestern …

Clinical, Tumor, And Product Features Associated With Outcomes After Axicabtagene Ciloleucel Therapy In Follicular Lymphoma, Soumya Poddar, Jiali Yan, Gayatri Tiwari, Darawan Rinchai, Justin Budka, Wangshu Zhang, Weixin Peng, Shruti Salunkhe, Madison Davis, Qinghua Song, Sara Beygi, Harry Miao, Mike Mattie, Rhine S Shen, Caron A Jacobson, Davide Bedognetti, Simone Filosto, Sattva S Neelapu

Faculty, Staff and Student Publications

Background: Axicabtagene ciloleucel (axi-cel), anti-CD19 chimeric antigen receptor (CAR) T cell therapy, demonstrated remarkable efficacy with manageable toxicity in relapsed/refractory indolent B cell lymphomas in the ZUMA-5 trial.

Methods:Here, we report associations of product attributes, serum biomarkers, clinical features, and tumor characteristics with outcome in 124 patients with follicular lymphoma (FL).

Results: In univariate and multivariate analyses, pretreatment inflammatory markers, including TNF-α and IL-12p40, as well as total metabolic tumor volume (TMTV), associated with disease progression. Conversely, T-naive–like product phenotype associated with improved outcome, particularly in patients with high TMTV. These covariates improved risk stratification when combined with the …

Contemporary Outcomes Of Octa-Nonagenarians With Newly Diagnosed Acute Myeloid Leukemia, Jayastu Senapati, Hagop M Kantarjian, Tapan M Kadia, Jeannot Kekedjian, Gautam Borthakur, Naval Daver, Courtney D Dinardo, Elias Jabbour, Prithviraj Bose, Nicholas J Short, Musa Yilmaz, Nitin Jain, Naveen Pemmaraju, Hussein A Abbas, Ghayas C Issa, Abhishek Maiti, Guillermo Montalban Bravo, Indraneel Deshmukh, Elizabeth Shpall, Partow Kebriaei, Uday Popat, Sanam Loghavi, Beenu Thakral, Guilin Tang, Fadi G Haddad, Yesid Alvarado, Guillermo Garcia Manero, Farhad Ravandi

Faculty, Staff and Student Publications

Background: Octa-nonagenarians with acute myeloid leukemia (AML) represent a high-risk group due to frequently poor performance status, adverse genomics (e.g., TP53 mutations, complex karyotype), a high incidence of secondary AML, and inability to undergo an allogeneic stem cell transplantation. Evaluating their outcomes with modern treatment approaches is important.

Methods: This retrospective study analyzed outcomes of patients ≥80 years old with newly diagnosed AML treated at our center from 2013-2023.

Results: A total of 289 patients (median age, 83 years; range, 80-95 years) were included. Venetoclax containing low-intensity therapy was administered to 107 patients (37.0%). AML subtypes included de novo (123, …

Outcomes Of Patients With Newly Diagnosed Acute Myeloid Leukemia With Flt3-Tyrosine Kinase Domain Mutations: Prognostic Implications Of Npm1 Co-Mutation, Sankalp Arora, Wei-Ying Jen, Musa Yilmaz, Indraneel Deshmukh, Jayastu Senapati, Sanam Loghavi, Ghayas C Issa, Nicholas J Short, Tapan M Kadia, Courtney D Dinardo, Gautam Borthakur, Joseph Jabbour, Naveen Pemmaraju, Michael Andreeff, Koichi Takahashi, Kapil Bhalla, Uday Popat, Elizabeth J Shpall, Betul Oran, Hussein A Abbas, Guillermo Garcia-Manero, Farhad Ravandi, Hagop Kantarjian, Naval Daver

Faculty, Staff and Student Publications

Background: The prognostic impact of Fms-like tyrosine kinase 3 (FLT3)-tyrosine kinase domain (TKD) mutation in patients with acute myeloid leukemia (AML) is not well defined. The authors described outcomes of one of the largest cohorts of patients with FLT3-TKD mutated (FLT3-TKDmut) AML to date.

Methods: This retrospective study included patients with newly diagnosed AML who received frontline treatment at The University of Texas MD Anderson Cancer Center from January 2012 to March 2024 divided into two cohorts: FLT3-TKDmut AML and nucleophosmin-mutated (NPM1mut)/FLT3-TKD wild-type (FLT3-TKDwt) AML. Patients with FLT3 internal tandem duplication mutations were excluded.

Results: In total, 2922 patients were …

Staff Education On The Columbia-Suicide Severity Rating Scale, Nathlie Ndokame

Walden Dissertations and Doctoral Studies

Summary This was a staff education project aimed at improving nurse knowledge on the Columbia-Suicide Severity Rating Scale (C-SSRS) tool. The identified gap in practice was a lack of knowledge and confidence among psychiatric nursing staff in utilizing this evidence-based suicide risk assessment tool. This project question was as follows: Does the implementation of an education program for psychiatric nursing staff on the use of the Columbia-Suicide Severity Rating Scale improve knowledge of patients at risk for suicide? The project employed the ADDIE framework and the Johns Hopkins evidence-based practice model. A comprehensive literature search was conducted, yielding 67 relevant …

Rna’S Symphony: Harmonizing Splice Junctions And Exon Counts For A Novel Approach To Differential Splicing Analysis, Jelard Aquino

UNLV Theses, Dissertations, Professional Papers, and Capstones

Alternative Splicing (AS) plays a critical role in transcriptome complexity and cell-type-specific gene regulation, yet its analysis remains methodologically fragmented, especially in the context of noisy and sparse single-cell RNA sequencing (scRNA-seq) data. This dissertation addresses key computational challenges in AS detection by evaluating existing tools, developing integrative frameworks, and proposing new strategies for improving analysis accuracy in both bulk and single-cell contexts. In chapter 1, I present a comprehensive literature review of computational tools designed for detecting and quantifying AS from bulk and scRNA-seq data. This review outlines major methodological paradigms, including exon-based and splice junction-based approaches, and evaluates …

Empowering Science With The World's First High Accuracy And High Throughput Functional Assay, Christopher Giacoletto

UNLV Theses, Dissertations, Professional Papers, and Capstones

Understanding the functional consequences of genetic mutations remains a central challenge in modern biology, with far-reaching implications for human health and disease. While early systematic methods like alanine scanning and phage display provided foundational insights into protein structure and function, the emergence of high-throughput approaches—such as Multiplexed Assays of Variant Effect (MAVEs)—and predictive tools powered by artificial intelligence have vastly expanded our ability to profile mutational landscapes. However, these methods are often constrained by trade-offs between accuracy, scalability, and biological relevance.This dissertation presents the development and application of the GigaAssay, the world’s first high-throughput functional assay capable of delivering both …