Digital Commons Network^™

Ontology Accelerates Few-Shot Learning Capability Of Large Language Model: A Study In Extraction Of Drug Efficacy In A Rare Pediatric Epilepsy, Pedram Golnari, Katrina Prantzalos, Veronica Hood, Mary Anne Meskis, Lori L Isom, Karen Wilcox, Jack M Parent, Dennis Lal, Samden D Lhatoo, Howard P Goodkin, Elaine C Wirrell, Kelly G Knupp, Manisha Patel, Jeffrey A Loeb, Joseph E Sullivan, Lauren Harte-Hargrove, Brandy E Fureman, Jeffrey Buchhalter, Satya S Sahoo

Faculty, Staff and Student Publications

OBJECTIVE: Dravet Syndrome (DS) is a developmental and epileptic encephalopathy that is characterized by severe, prolonged motor seizures and high resistance to multiple antiseizure medications (ASMs) with multiple comorbidities. Evaluating the efficacy of new drugs in DS preclinical models and mapping them to human phenotypes of DS through analysis of published literature is an important goal for improving outcomes in this rare pediatric epilepsy.

MATERIALS AND METHODS: Large language models (LLM) have demonstrated great promise in parsing published literature; however, the performance of LLMs falls short in medical applications. In this study, we investigate the effectiveness of domain ontology developed …

Reasoning From Injustice, Robert L. Tsai

Michigan Journal of Race and Law

In a series of lectures at Yale Law School, the Harvard political theorist Judith Shklar critiqued leading models of justice as overly abstract and lacking a realistic account of the social dynamics that perpetuate injustice. In this essay, Professor Tsai builds on Shklar’s account of injustice as a social phenomenon by offering a structural reading of key literary texts that explore the nature of legal injustice—from the Book of Job to Harriett Beecher Stowe’s Uncle Tom’s Cabin and Frederick Douglass’s The Heroic Slave. A close reading of these texts permits us to flesh out Shklar’s observations and “give injustice …

(Re)Birth Of A Nation: Reconstruction’S Unfinished Business, Zanita E. Fenton

Michigan Journal of Race and Law

The irony, alluding to the title of the 1915 silent movie Birth of a Nation, seeks to make conspicuous the counter-stories that more authentically account for the “birth” and development of American society. Ku Klux Klan-sponsored propaganda designed to evoke hyper-racist fearmongering and perpetuate sexual paternalism over White women, the plot from Birth of a Nation reflects the paradigmatic race-bait: relentless pursuit of a White woman by a Black man. This storyline was fictionalized, culturally unrealistic and deliberately omitted the very real sexual exploitation of Black women and girls. Birth of a Nation parallels Constitutional history that marginalizes supplemental …

An In-Depth Criticism Of Shaw V. Reno, Katherine M. Perez-Oviedo

Michigan Journal of Race and Law

If I have learned one thing from my semester taking Critical Race Theory, it is that the United States Supreme Court has repeatedly issued decisions that directly impede on remedial efforts to address past racial discrimination. When the question of “how can we use the law to instill social change?” is proposed in class discussion, it is difficult to imagine a world in which the Court would support the progressive measures suggested.

Uncovering Red Flags In The Silver State: Recognizing And Expanding The Corporate Duty Of Oversight In Nevada, Daren Dunaway

Nevada Law Journal

No abstract provided.

Build, Buy, Or Both?: On The Antitrust Laws' Supposed Preference For "Internal Growth" Over Acquisitions, Geoffrey A. Manne, Justin (Gus) Hurwitz

Nevada Law Journal

This Article challenges recent claims by antitrust enforcers that the U.S. antitrust laws embody a preference for “internal” or “organic” growth over external expansion through acquisition. It begins by examining the modern use of this claim in speeches, enforcement actions, and the 2023 Merger Guidelines issued by the Federal Trade Commission and Department of Justice. It then considers the legislative history of the 1950 Celler-Kefauver and 1976 Hart-Scott-Rodino Acts, which are frequently cited as showing congressional support for internal growth. Careful reading of these Acts, however, shows that Congress’s central goal was to close a loophole regarding asset acquisitions, and …

Immigration Detention Expansion By Stealth, Denise Gilman

Nevada Law Journal

No abstract provided.

Organization Research As An Applied Science: Lessons From Fields That Shape Practice And Policy, Stephen X. Zhang, Gokhan Ertug

Research Collection Lee Kong Chian School Of Business

As an applied science, our field aims to improve organizational effectiveness and solve practical problems (Hideg, DeCelles & Tihanyi, 2020; Pfeffer & Fong. 2002; Pillutla & Thau, 2013). However, despite the increasing sophistication in methods and greater emphasis on theory in recent decades, we have not made commensurate strides in relevance and impact. As we see it, the heart of this challenge is the culture in our field that demands novel theoretical advancement from every paper (Aguinis & Cronin, 2022), which may inadvertently constrain our ability to address pressing organizational challenges. Previous appeals to enhance our impact as an applied …

Monitoring Nutrition Security: Perspectives From A Workshop On Nutrition Security Measurement, Ximena Perez-Velazco, Edward A. Frongillo Jr. Ph.D., Joanne F. Guthrie, Alisha Coleman-Jensen, Mariah D. Ehmke, Christian Gregory, Hilary K. Seligman

Faculty Publications

Nutrition security, an emerging concept distinct from and complementary to food security, has gained increasing interest as a focus of efforts to reduce hunger, improve nutrition, and prevent diet-related health conditions. Yet, unlike food security, which has well-established measures, nutrition security lacks standardized measures for assessment. This gap hinders the ability to evaluate progress in improving nutrition security both in the United States and globally. In September 2024, a workshop to explore how to measure nutrition security was hosted by the United States Department of Agriculture Economic Research Service, in collaboration with the Southern University Agricultural Science Center of Excellence …

Experiences Of Emotional Support Among Parents Of Children And Adolescents With Type 1 Diabetes: A Qualitative Study, Sahar S Eshtehardi, Marissa N Baudino, Barbara J Anderson, Deborah I Thompson, David G Marrero, Marisa E Hilliard

Faculty, Staff and Students Publications

Objective: Parents of youth with type 1 diabetes (T1D) experience substantial disease-specific demands and distress, yet their perceptions about the emotional support they receive related to the challenges of caring for a child with diabetes have not been well described. This research aimed to characterize the types of emotional support parents of youth with T1D receive and how they experience emotional support.

Methods: As part of a larger qualitative study on diabetes health-related quality of life, 23 parents (96% mothers) of youth with T1D (M age = 10.9 ± 3.8 years; 35% female) completed semi-structured interviews about various aspects of …

September 2025 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Elephant Endotheliotropic Herpesvirus 2 Infection In 5 African Elephants (Loxodonta Africana) At Multiple North American Zoological Institutions, Taylor J Willis, Anne Burgdorf-Moisuk, Maren Connolly, Jan Raines, Cameron Ratliff, Zoltan S Gyimesi, Erica Lipanovich, Genevive A Dumonceaux, Kathryn L Perrin, Lauren L Howard, Matthew E Kinney, Kirk Suedmeyer, Erin Latimer, Tiffany L Kim, Jessica R Watts, Jie Tan, Paul Ling

Faculty, Staff and Students Publications

Objective: To acknowledge that elephant endotheliotropic herpesvirus (EEHV) is a well-recognized major threat to Asian elephants (Elephas maximus) and can cause acute and often fatal hemorrhagic disease (HD). Historically, EEHV-HD has been less frequently identified in African elephants (Loxodonta africana). This case series describes 5 recent cases of EEHV2 infection in African elephants within managed care at 5 North American institutions.

Animals: 5 African elephants (L africana).

Clinical presentation: The cases involved 4-, 7-, and 10-year-old males that died despite receiving aggressive medical therapy and 4- and 14-year-old females that survived. Clinical signs included lethargy, decreased appetite, lameness, changes in …

Spatial Omics Enters The Microscopic Realm: Opportunities And Challenges, Yichen Si, Joo Sang Lee, Goo Jun, Hyun Min Kang, Jun Hee Lee

Faculty, Staff and Students Publications

Spatial transcriptomics (ST) enables systematic profiling of whole-transcriptome gene expression in tissues while preserving spatial context. Recent advances in sequencing- and imaging-based ST technologies have ushered in the era of microscopic-resolution ST (μST), allowing transcriptome mapping at cellular and even subcellular scales with unprecedented precision. Despite these advances, μST faces substantial challenges, including sparse transcript discovery per submicron (or micron)-sized spatial units and data fragmentation across platforms, hindering integration and analysis. There is also a growing demand for scalable, segmentation-free, and universally applicable analysis methods, as well as strategies for 3D mapping, multi-omics integration, and artificial intelligence (AI)-driven spatial analysis. …

Shallow Coastal Bays As Sediment Carbon And Nutrient Reservoirs In The Baltic Sea, Betty Gubri, Joakim P. Hansen, Sofia A. Wikström, Martin Snickars, Martin Dahl, Martin Gullström, Emil Rydin, Pere Masqué, Andrius Garbaras, Mats Björk, Christoffer Boström

Research outputs 2022 to 2026

Coastal vegetated ecosystems are being increasingly recognized for their capacity to capture carbon, provide long-term biogenic storage, and alleviate nutrient pollution. To assess the ability of shallow, vegetated coastal bays to function as blue carbon and nutrient (nitrogen and phosphorus) sinks, we collected sediment cores in nine shallow enclosed bays (representative of the EU Habitats 1153 and 1154) in the archipelago areas of Sweden (Stockholm), Åland Island, and southwestern Finland. Our study showed strong uniformity of carbon and nutrient storage, substantial accumulation of carbon and nutrients, and minimal regional differences in carbon, nitrogen, and phosphorus sediment stocks. These findings are …

A Large-Scale Multi-Centre Study Characterising Atrophy Heterogeneity In Alzheimer's Disease, Vikram Venkatraghavan, Damiano Archetti, Pierrick Bourgeat, Chenyang Jiang, Mara Ten Kate, Anna C. Van Loenhoud, Rik Ossenkoppele, Charlotte E. Teunissen, Elsmarieke Van De Giessen, Yolande A.L. Pijnenburg, Giovanni B. Frisoni, Béla Weiss, Zoltán Vidnyánszky, Tibor Auer, Stanley Durrleman, Alberto Redolfi, Simon M. Laws, Paul Maruff, Neil P. Oxtoby, Andre Altmann, Daniel C. Alexander, Wiesje M. Van Der Flier, Frederik Barkhof, Betty M. Tijms

Research outputs 2022 to 2026

Previous studies identified atrophy-based Alzheimer's disease(AD) subtypes linked to distinct clinical symptoms, but their consistency across subtyping approaches remains unclear. This large-scale study evaluates subtype concordance using two data-driven approaches. In this work, we analyzed data from n=10,011 patients across 10 AD cohorts spanning Europe, the US, and Australia, extracting regional volumes using Freesurfer. To characterize atrophy heterogeneity in the AD continuum, we developed a two-step approach, Snowphlake (Staging NeurOdegeneration With PHenotype informed progression timeLine of biomarKErs), to identify subtypes and atrophy-event sequences within each subtype. Results were compared with SuStaIn (Subtype and Stage Inference), which jointly estimates subtypes and …

Socioeconomic Disadvantage, All-Cause And Cause-Specific Mortality In Patients Treated With Maintenance Dialysis: A Mediation Analysis Of Geographical Inequity And Multimorbidity, Farzaneh Boroumand, Wai H. Lim, Shuvo Bakar, Ryan Gately, Pedro Lopez, Dharshana Sabanayagam, Anita Van Zwieten, Lin Zhu, Germaine Wong, Armando Teixeira-Pinto

Research outputs 2022 to 2026

Rationale & Objective: Social gradient in health (a “social gradient in health” refers to the observed pattern in which individuals with lower socioeconomic status typically experience poorer health outcomes than those with higher socioeconomic status. This indicates that health disparities exist across different social levels, with the most disadvantaged groups experiencing the worst health outcomes) is significant and established in patients with kidney failure, but the pathways of this relationship are unknown. We aimed to assess the mediating effects of multimorbidity and geographical remoteness in the socioeconomic status (SES)-death associations. Study Design: A cohort study. Setting & Participants: All patients …

Comparison Of Decision-Making Skill In 360° Video To The Field Setting In Highly Skilled Rugby Union Players, Hannah J. Vawser, Khaya Morris-Binelli, Benjamin Piggott, Sean Müller, Paola Chivers, Evan Dekker

Research outputs 2022 to 2026

Little evidence exists of whether decision-making in immersive 360° video is representative of the field setting in sport. The purpose of this study was to investigate whether decision-making performance of a representative exemplar competition specific skill was similar between 360° video and a field task. Fifteen players from skilled junior rugby union pathways and professional rugby union teams in Australia were recruited to complete a 360° video decision-making choice response task involving four attackers and three defenders. Their decision-making was previously assessed in a similar field decision-making task that was representative of rugby game play. Decision-making was scored according to …

Occupational Exposure To Diesel Particulate Matter In Western Australian Mining: A Retrospective Analysis And Challenges To Future Compliance, Matthew Oosthuizen, Kerry Staples, Adelle Liebenberg, Kiam Padamsey, Marcus Cattani, Andy Mccarthy, Jacques Oosthuizen

Research outputs 2022 to 2026

De-identified diesel particulate matter (DPM) exposure data (n = 24,459) was obtained from the Western Australian mining regulator to assess compliance with the current Workplace Exposure Standard (WES) of 0.1 mg/m³, measured as submicron elemental carbon, and a proposed limit of 0.01 mg/m³, assessed as respirable elemental carbon. R and R-Studio were used to generate summary statistics comparing compliance to the current and proposed limits, stratified by industry and occupational groups. To examine temporal trends, a zero-adjusted gamma model was used to assess whether expected sample means changed over the past ten years, using commodity and …

Do Companies’ Green Credentials Enhance Trade Credit Provisions? Global Evidence, Rashid Zaman, Nader Atawnah, Deepa Banigidadmath, Muhammad Nadeem, Jia Liu

Research outputs 2022 to 2026

We investigate the impact of corporate renewable energy (RE) adoption on suppliers’ trade credit provisions. Using a global sample of 30 countries, we establish that firms engaging in higher RE consumption secure increased trade credit. Our results remain robust to a variety of sensitivity tests and after accounting for potential endogeneity concerns using the Paris Agreement and companies switching to green energy as exogenous shocks. Our channel analysis reveals that RE take-up mitigates companies’ environmental risk (proxied by environmental violation fines, media coverage of environmental controversies, GHG emissions, and environmental policy stringency). Additional tests reveal that the relationship between RE …

History Informing The Future Of Exercise Oncology, Daniel A. Galvão, Kerry S. Courneya, Alejandro Lucia, Anne M. May, Karen Mustian, Allison B. Warner, Wiskemann Joachim, Karen Wonders, Kathryn H. Schmitz, Robert U. Newton

Research outputs 2022 to 2026

Exercise is increasingly recognized by patients, clinicians, and allied health professionals globally as an important component of cancer care. In this paper, we provide a viewpoint on developments in exercise oncology over the past 4 decades leading up to the creation of the International Society of Exercise Oncology (ISEO). We briefly review research in adult and pediatric cancers from early foundation studies to larger randomized controlled trials published in mainstream oncology journals alongside critical work undertaken in exercise and cancer biological mechanisms. We also discuss potential strengths, weaknesses, opportunities, and threats facing ISEO in becoming a global forum for exercise …

Multi-Objective Optimization Of A Three-Level Sustainable Food Supply Chain: Modeling The Impact Of Government Subsidies, Reza Kiani Mavi, Majid Semiari, Seyed Ashkan Hosseini Shekarabi, Neda Kiani Mavi, Fatemeh Moshkdanian, Arezoo Nikravesh, Sadegh Golsorkhi

Research outputs 2022 to 2026

This study develops an integrated optimization framework which supports the sustainable design of a food supply chain with three echelons: suppliers, a central manufacturer, and retailers. The model minimizes total cost and carbon emissions while simultaneously maximizing the share of products made with certified green processes, capturing economic, environmental, and social pillars of sustainability. Government policy is represented through two distinct incentives: a per-unit subsidy for green production and a per-use subsidy for alternative fuel vehicles, both directly reducing relevant costs in the decision space. For scalability, a tailored non-dominated sorting genetic algorithm II (NSGA-II) is developed and benchmarked against …

Triage Tools To Inform The Prioritisation Of Physical Health Services Following A Diagnosis Of Cancer: A Scoping Review, Georgia L. White, Lauren C. Capozzi, Corey Linton, Adrian Wright, Tamara Jones, Hattie H. Wright, Kate A. Bolam, Elizabeth A. Johnston, Briana K. Clifford, Keegan Bean, Stephanie Brown, Sarah Kolesaric, Mary A. Kennedy, Bryan A. Chan, Grace L. Rose

Research outputs 2022 to 2026

Purpose: Many people face multiple cancer- and treatment-related sequalae. Triage and referral to physical health services can manage such consequences, but a comprehensive understanding of available triage tools is lacking. This review (i) identifies tools used to triage to physical health services, (ii) maps tool characteristics and application outcomes and (iii) summarises existing gaps. Methods: A systematic search was conducted (three databases, April 2024). Articles were included if they used a tool to triage to physical health services. Tools were classified by triaged disciplines (i.e., diet, exercise, physical rehabilitation, multidisciplinary) and screened physical impairments (e.g., malnutrition). Tool characteristics (e.g., triage …

A Systematic Review Using A Multi-Layered Criteria Framework For Assessing The Validity And Reliability Of Velocity Monitoring Devices In Resistance Training, Youssef J. Wannouch, Samuel R. Leahey, Rodrigo Ramírez-Campillo, Harry G. Banyard, Harry S. Dorrell, Steven Stern, Gordon J. Ross, Jason C. Laffer, Kelvin Y.H. Chua, Paul Comfort

Research outputs 2022 to 2026

Background Velocity-Based Training (VBT) is an emerging method in resistance training for objectively prescribing and monitoring training intensity and neuromuscular function. Given its growing popularity, assessing the validity and reliability of VBT devices is critical for strength and conditioning coaches. Objective The primary purpose of this review was twofold: (1) to identify and address methodological gaps in current assessments of VBT device validity and reliability, and (2) to propose and apply a novel, multi-layered, criterion-based framework—developed in collaboration with statisticians and domain experts—for evaluating these devices. Methods A systematic search was conducted in PubMed, Scopus, and SPORTDiscus following PRISMA guidelines, …

More Prioritisation On Food Security – Exploring What Initiative Leaders Envision For A Food Secure Regional Australia, Isabelle Chiera, Jess Doe, Melissa Stoneham, Saranne Herrington, Amanda Devine, Emily Humphreys, Stephanie L. Godrich

Research outputs 2022 to 2026

Food security is a particular challenge in rural, regional and remote locations due to complexities associated with food availability, access, utilisation, stability, agency and sustainability dimensions. Existing approaches, such as emergency food relief, have been found to inadequately address these challenges, suggesting that a comprehensive portfolio of solutions could be more effective. Understanding what food security initiative leaders operating in these areas consider important will help establish a shared goal to guide the development of a portfolio approach. This paper aimed to determine government and community-led food security initiative leaders' visions of a food secure regional Australia. This qualitative study …

Muscle Creatine Levels And Sprint Performance In Young Adult Vegans And Vegetarians After 7 Days Of Creatine Monohydrate Supplementation, Thomas Christian Bonne, Valentina Arthemalle, Colin Stephen Doherty, Andreas Breenfeldt Andersen, Jacob Bejder, Thomas Ehlers, Henrik Holm-Sørensen, Nikolai Baastrup Nordsborg

Research outputs 2022 to 2026

Athletes use creatine monohydrate (CM) to enhance high-intensity exercise performance by increasing creatine phosphate availability. While CM supplementation is known to raise muscle creatine levels in vegans and vegetarians, its impact on exercise performance remains uncertain. We examined the effects of CM supplementation on muscle creatine content and exercise performance in vegans and vegetarians. In a randomized, double-blind placebo-controlled design, 15 healthy vegans and vegetarians consumed CM (0.3 g/kg/day, n = 7) or placebo (PLA, 0.3 g maltodextrin/kg/day, n = 8) four times a day for 7 days. Before and after supplementation, repeated sprint capacity was determined. Body mass and …

Waste By-Products In Asphalt Concrete Pavement Construction: A Review, Nuha S. Mashaan, Daniel O. Oguntayo, Chathurika Dassanayake

Research outputs 2022 to 2026

The use of mining by-products in bitumen and asphalt mixture modification has drawn a lot of interest lately since it can improve pavement performance while advancing the goals of the circular economy and environmental sustainability. Mining by-products such as steel slag, red mud, silica fume, and fly ash have demonstrated good results as sustainable materials for improving the chemical, mechanical, durability, and rheological properties of asphalt binders and mixtures while also reducing the environmental degradation brought about by the disposal of these by-products. This study reviews research efforts on mining by-products (specifically steel slag, silica fume, red mud, and fly …

A Fascination With Gastrointestinal Viruses, Mary Kolb Estes

Faculty, Staff and Students Publications

My arrival into this world came quickly, according to my mother, and it feels like my life has mirrored that rapid beginning. I have enjoyed a rich, varied, and stimulating life and career that have gone through several phases. I credit genetics, my family, technological advances, and many environmental factors for shaping my career. Being a virologist allowed me to be curious and creative and to make several unexpected discoveries. This has been a fun and rewarding journey, but it wasn't always easy. I am not accustomed to talking about myself, but I am happy to share some scientific achievements …

The Outcomes Of A Structured Bowel Management Programme On Childhood Functional Constipation: A Retrospective Pre – Post Intervention Study, Gunilla Flankegård, Peter Wide, Evalotte Mörelius

Research outputs 2022 to 2026

Aim: The purpose of this study was to describe and evaluate the effectiveness of a six-month structured bowel management programme (SBMP) for children with therapy-resistant functional constipation (FC). Method: A retrospective review of medical records with a pre-post design was conducted at an outpatient paediatric clinic in Sweden. Bowel frequency, stool form, faecal incontinence, and abdominal pain were compared before and after the intervention. Predictive factors for successful discharge and duration of care through long-term follow-up were calculated. Results: Of the 142 children enrolled in the SBMP, 132 completed the programme. Despite previous FC therapy resistance, the SBMP achieved a …

Automated Instance Segmentation And Registration Of Spinal Vertebrae From Ct-Scans With An Improved 3d U-Net Neural Network And Corner Point Registration, James Hill, Muhammad Rizwan Khokher, Chuong Nguyen, Matt Adcock, Ron Li, Stuart Anderson, Thomas Morrell, Tim Diprose, Olivier Salvado, Dadong Wang, Guan K. Tay

Research outputs 2022 to 2026

This paper presents a rapid and robust approach for 3D volumetric segmentation, labelling, and registration of human spinal vertebrae from CT scans using an optimised and improved 3D U-Net neural network architecture. The network is designed by incorporating residual and dense interconnections, followed by an extensive evaluation of different network setups by optimising the network components like activation functions, optimisers, and pooling operations. In addition, the network architecture is optimised for varying numbers of convolution layers per block and U-Net levels with fixed and cascading numbers of filters. For 3D virtual reality visualisation, the segmentation output of the improved 3D …

Wound-Healing And Onboard Care During Long-Duration Human Deep Space Exploration From A Surgical Perspective Through The Lens Of A Scoping Review, Dora Babocs, Krishi Korrapati, Cooper Lytle, Monika L Gloviczki, Gustavo S Oderich, M Mark Melin, Rowena Christiansen

Faculty, Staff and Students Publications

Objective: The aim of this study was to develop a bridge between the fields of aerospace medicine and vascular surgery, and to emphasize the need for leading experts in vascular medicine, interventional radiology, and surgery to address the critical human spaceflight research gaps highlighted by the National Aeronautics and Space Administration (NASA).

Methods: A scoping review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted on literature published between 2000 and 2024. A well-defined search strategy was employed for keyword searches across multiple databases, including PubMed, Scopus, Cochrane, Embase, the NASA Life Science Data Archive, …