Digital Commons Network^™

Accelerating Precision Exercise Medicine In Cancer Patients Using Pooled Individual Patient Data: Polaris Experience, Laurien M. Buffart, Marlou Floor Kenkhuis, Robert U. Newton, Anne M. May, Daniel A. Galvão, Kerry S. Courneya

Research outputs 2022 to 2026

Numerous exercise oncology trials have been completed, greatly informing exercise recommendations for patients with cancer. Exercise medicine can be administered in various types, doses, and schedules at various time points. Advancing precision exercise medicine requires understanding of how the effects of different exercise interventions vary by characteristics of individual patients. The Predicting OptimaL cAncer RehabIlitation and Supportive care (POLARIS) study provides an international infrastructure and shared database to perform pooled analyses of individual patient data (IPD) from multiple randomized controlled trials. This commentary aims to highlight the value of pooled IPD analyses, summarize key findings from published pooled IPD analyses …

Co-Design Of A Weekly Meal Box For Neurological Conditions: Findings From Consumer And Healthcare Provider Collaborative Workshops, Joanna Rees, Kelly Moes, Amanda Devine, Melanie Clark, Ros Sambell, Simon Laws, Travis Cruickshank

Research outputs 2022 to 2026

Introduction: This study explores the collaborative co-design process for developing a weekly meal box tailored for individuals with neurological conditions. Recognising the critical role of nutrition for this community, the research addresses the challenges posed by cognitive and physical impairments in meal preparation. Methods: Through two co-design workshops involving consumers, healthcare providers and industry experts, insights were gathered on dietary preferences, nutritional needs and practical challenges. Results: The workshops emphasised the importance of convenient, easy-to-prepare meals with simple instructions, flexibility and customisability. Consumers expressed preferences for convenient, easy-to-prepare meals with simple, easy-to-follow recipe instructions that align with optimal dietary patterns …

Co-Designing A Resilience-Based Mentoring Program For Novice Midwives: A Participatory Action Research Approach, Dianne Bloxsome, Tracy Martin, Kaoru Nosaka, Sara Bayes

Research outputs 2022 to 2026

Aim: To co-design a resilience-based mentoring program for novice midwives in Western Australia, informed by the experiences of past midwifery graduates and the perspectives of midwives in senior roles. Background: Effective workforce planning and retention strategies are essential in preventing the continued loss of midwives and in attracting newly qualified midwives to healthcare organisations. Transitioning from student to registered midwife is a known period of vulnerability that requires structured, evidence-informed support. Design: A Participatory Action Research (PAR) approach was adopted to collaboratively develop a mentoring program tailored to the transition needs of newly qualified midwives. Methods: Fourteen participants contributed to …

Decarbonising The Uk Pulp, Paper And Printing Sector: Balancing Sustainability And Global Competitiveness Through Insights From Lmdi And Mrio Analysis, T. Ibn-Mohammed, A. C. Serrenho, H. Fujii, A. Acquaye, A. Morrison-Saunders

Research outputs 2022 to 2026

The United Kingdom's pulp, paper, and printing sector (UKPPP) contributes ∼6 % of the nation's industrial CO2 emissions. While these emissions have declined since 2000, mainly because roughly half its paper mills closed due to global competitiveness challenges, other factors influencing emission dynamics (e.g., carbon intensity, energy intensity, fossil fuel dependency, economic structure, and activities) remain quantitatively unevaluated in comparison to other top global PPP countries (TGPPP). Additionally, the UKPPP relies on imports from TGPPP. Yet, a comprehensive modelling of the ecological CO2 emission exchanges and a comparison of sectoral production structures and emission dynamics between these entities have not …

Exploring Preferences For Interventions To Increase Active School Transportation Among Children And Adolescents In Australia, Anna Gannett, Paula Hooper, Julie Saunders, Gina Trapp

Research outputs 2022 to 2026

Introduction: The observed decline in children's active school transport (AST) across numerous countries over recent decades necessitates targeted, multi-level interventions to reverse this trend. However, data on young people's preferred AST interventions is lacking. This study aimed to explore children's preferences for AST interventions and assess differences between AST users and non-users among primary and secondary school students. Methods: In 2023, a cross-sectional survey was conducted in Perth, Western Australia with n = 742 primary school students from 23 schools and n = 412 secondary school students from 9 schools. The survey assessed AST frequency, preferred transport mode, and AST …

Factors Influencing The Effectiveness Of Machine Learning Algorithms In Predicting Raw Wastewater Characteristics: An Analysis Based On Weekly Field Data, Hoda Khoshvaght, Ratish Ramyad Permala, Amir Razmjou, Mehdi Khiadani

Research outputs 2022 to 2026

Accurate prediction of raw wastewater characteristics can reduce laboratory costs, enable optimized chemical dosing, and improve the overall efficiency of wastewater treatment plant (WWTP) operations. This study evaluates machine learning (ML) models as a fast, sustainable, and cost-effective alternative for predicting Biochemical Oxygen Demand (BOD) and Ammonia Nitrogen (NH4⁺-N) in raw wastewater. Seven ML algorithms, including tree-based, neural, and regression approaches, were trained using standard wastewater indicators, including organic load, nutrient levels, and pH, with hyperparameters tuned via grid search cross-validation. Model performance was evaluated using correlation-based (R²) and error-based metrics (RMSE, MAE, MAPE) to ensure …

Sleep Environment Is Associated With Sleep Control In Fly-In, Fly-Out Mining Shift Workers, Philipp Beranek, Mitchell Turner, Johnny Lo, Michael Grandner, Ian C. Dunican, Travis Cruickshank

Research outputs 2022 to 2026

Control over sleep timing, duration, and quality is essential for obtaining healthy sleep. Fly-in, Fly-out (FIFO) mining shift workers face unique challenges in maintaining control over their sleep due to their roster. However, the impact of their sleep environment on perceived sleep control in this population remains underexplored. This study evaluates the sleep environment of FIFO mining shift workers and its association with sleep control. A cross-sectional study was conducted (2023–2024) on Australian FIFO mining shift workers residing in remote camp accommodations. Data were collected via an online survey using the Assessment of Sleep Environment (ASE) and the Brief Index …

Soft Sensing Of Biological Oxygen Demand In Industrial Wastewater Using Machine Learning Models, Muhammad Hassnain, Sarada M.W. Lee, Muhammad Rizwan Azhar

Research outputs 2022 to 2026

Traditional methods for determining biological oxygen demand (BOD) from industrial water resource recovery facilities (WRRFs) are time-consuming and often impractical for real-time process control. This study explores the application of machine learning (ML) and artificial intelligence (AI) models for the prediction of final effluent BOD (F-BOD) based on physicochemical and operational parameters by leveraging nineteen years of historical laboratory and instrumentation data from the WRRF of an essential oil manufacturing plant. The predictions from these models are then used to simulate the process dynamics, assessing the optimal operational boundary conditions for all input parameters at which the target (F-BOD) falls …

Understanding Interprofessional Co-Debriefing Practices Within Large Scale Ward-Based Simulation, Melanie Barlow, Robyn Dickie, Alycia Jacob, Shari Maver, Nick Flynn, Alison Blunt, Susan Darzins, Hugh Davies, Michelle Smith-Tamaray, Elisabeth Jacob

Research outputs 2022 to 2026

Background: Despite growing use of interprofessional simulation in healthcare education, there is a lack of published frameworks to guide structured, co-facilitated debriefing between professions. This study explored how nursing and allied health facilitators engage in interprofessional co-debriefing within a large-scale, ward-based simulation program involving over 2000 health students. Methods: Twelve interprofessional co-debriefings were observed and assessed using the debriefing assessment for simulation in healthcare (DASH) tool, with both rater (observer) and instructor (debriefer) versions. Mean debriefing assessment for simulation in healthcare (DASH) scores were compared across five core elements. Qualitative data from instructor short-answer responses and observer field notes were …

A Risk-Averse Data-Driven Distributionally Robust Optimization Method For Transmission Power Systems Under Uncertainty, Mehrdad Ghahramani, Daryoush Habibi, Asma Aziz

Research outputs 2022 to 2026

The increasing penetration of renewable energy sources and the consequent rise in forecast uncertainty have underscored the need for robust operational strategies in transmission power systems. This paper introduces a risk-averse, data-driven distributionally robust optimization framework that integrates unit commitment and power flow constraints to enhance both reliability and operational security. Leveraging advanced forecasting techniques implemented via gradient boosting and enriched with cyclical and lag-based time features, the proposed methodology forecasts renewable generation and demand profiles. Uncertainty is quantified through a quantile-based analysis of forecasting residuals, which forms the basis for constructing data-driven ambiguity sets using Wasserstein balls. The framework …

Assessing Compliance With Evolving Exposure Standards: Respirable Crystalline Silica (Rcs) Exposure In Western Australian Mining, Adelle Liebenberg, Kiam Padamsey, Kerry Staples, Matthew Oosthuizen, Marcus Cattani, Andy Mccarthy, Jacques Oosthuizen

Research outputs 2022 to 2026

The link between occupational exposure to Respirable Crystalline Silica (RCS) and silicosis, a potentially fatal respiratory disease, has been well-established, leading to global reductions in RCS Exposure Standards (ES). In Western Australia (WA), RCS data have been collected by the Department of Energy, Mining, Industry Regulation and Safety (DEMIRS) from 1986 to 2024 (n = 144,141). These results were analysed to assess the impacts of recent changes to the ES on compliance. Findings suggest that the WA mining sector, regardless of commodity type, is compliant with RCS exposures as assessed against the 0.05 mg/m³ ES (2019). Laboratory technicians, exploratory …

Calcium Supplementation And The Risk Of Dementia In The Perth Longitudinal Study Of Aging Women: A Post-Hoc Analysis Of A Randomised Clinical Trial For Fracture Prevention, Negar Ghasemifard, Joshua R. Lewis, Simone Radavelli-Bagatini, Simon M. Laws, Blossom C.M. Stephan, Jonathan M. Hodgson, Kun Zhu, Richard L. Prince, Marc Sim

Research outputs 2022 to 2026

Background: Concerns have been raised around whether calcium supplements increase dementia risk. This post-hoc analysis of a five-year double-blind, placebo-controlled randomised trial of calcium supplements for primary fracture prevention evaluated the long-term risk for dementia in older women, randomised to either calcium supplements or placebo. Methods: 1460 community-dwelling dementia-free Australian women (≥70 years) were randomised to 1200 mg/day calcium carbonate (n = 730) or placebo (n = 730) for five years and were observed for an additional 9.5 years afterwards. Over 14.5 years, all-cause dementia events (comprising dementia-related hospitalisations and/or deaths) were identified from linked health records. The influence of …

Effects Of Exercise On Inflammation In Female Survivors Of Nonmetastatic Breast Cancer: A Systematic Review And Meta-Analysis, Francesco Bettariga, Dennis R. Taaffe, Anita Borsati, Alice Avancini, Sara Pilotto, Stefano G. Lazzarini, Pedro Lopez, Luca Maestroni, Umberto Crainich, John P. Campbell, Timothy D. Clay, Daniel A. Galvão, Robert U. Newton

Research outputs 2022 to 2026

Background: Despite advances in breast cancer treatment, recurrence remains common and contributes to higher mortality risk. Among the potential mechanisms, inflammation plays a key role in recurrence by promoting tumor progression. Exercise provides a wide array of health benefits and may reduce inflammation, potentially reducing mortality risk. However, the effects of exercise, including mode (ie, resistance training [RT], aerobic training [AT], and combined RT and AT) and program duration, on inflammatory biomarkers in breast cancer survivors remain to be elucidated. Methods: A systematic search was undertaken in PubMed, CINAHL, Embase, SPORTDiscus, and CENTRAL in August 2024. Randomized controlled trials examining …

Explainabledetector: Exploring Transformer-Based Language Modeling Approach For Sms Spam Detection With Explainability Analysis, Mohammad Amaz Uddin, Muhammad Nazrul Islam, Leandros Maglaras, Helge Janicke, Iqbal H. Sarker

Research outputs 2022 to 2026

Short Message Service (SMS) is a widely used and cost-effective communication medium that has unfortunately become a frequent target for unsolicited messages - commonly known as SMS spam. With the rapid adoption of smartphones and increased Internet connectivity, SMS spam has emerged as a prevalent threat. Spammers have recognized the critical role SMS plays in today's modern communication, making it a prime target for abuse. As cybersecurity threats continue to evolve, the volume of SMS spam has increased substantially in recent years. Moreover, the unstructured format of SMS data creates significant challenges for SMS spam detection, making it more difficult …

Healing Right Way: A Stepped Wedge Cluster Randomised Controlled Trial Aiming To Enhance Quality Of Life For Aboriginal Australian Survivors Of Stroke And Traumatic Brain Injury, Elizabeth Armstrong, Tapan Rai, Judith M. Katzenellenbogen, Sandra J. Thompson, Meaghan Mcallister, Natalie Ciccone, Deborah Hersh, Leon Flicker, Dominique A. Cadilhac, Erin Godecke, Graeme J. Hankey, Neil Drew, Colleen Hayward, Deborah Woods, Mel Robinson, Ivan Lin, Sanita Kratina, Jane White, Juli Coffin

Research outputs 2022 to 2026

Objective: To determine the effect of cultural security training (CST) for health professionals and access to an Aboriginal Brain Injury Coordinator (ABIC) for Aboriginal Australians with stroke or traumatic brain injury (TBI). Design: A stepped wedge cluster randomised controlled trial; the intervention package consisted of CST for hospital professionals and 6-month access to ABICs providing education, support, liaison and advocacy; the commencement order of the intervention phase was randomised. Setting: Four urban and four rural hospitals in Western Australia, 2018–2022. Participants: Aboriginal adults ≥ 18 years hospitalised with stroke or TBI. Main Outcome Measures: Primary outcome was quality of life …

I Know What To Say Now: Students' Evaluation And Utilisation Of Accidental Counsellor Training, Joanna E. Harnett, Claire E. Ashton-James, James Kite, Tonia Crawford, Sanetta H.J. Du Toit, Leigh A. Wilson, Rosa Howard

Research outputs 2022 to 2026

Introduction In 2020 and 2021, 280 health profession students who were engaged in student leadership roles and peer mentoring were invited to undertake extracurricular training in accidental counselling to build skills in recognising and responding to a person in distress. The aim of this study was to evaluate the acceptability of the online training course, and to explore students’ confidence to use Accidental Counsellor tools to support peers in distress after completion of the training course. Methods A retrospective cohort study including a post- intervention only design was used. A survey was administered approximately 12 months after 225 students completed …

I’M Here Whether I Like It Or Not: A Focused Ethnographic Description Of Transition Into Residential Aged Care, Stacey Scott, Annette Raynor, Julie Dare, Jennifer Grieve, Leesa Costello

Research outputs 2022 to 2026

Transition into residential aged care (RAC) is a challenging process, often characterised by vulnerability, fear, and isolation. This study aimed to provide a contextualised description of transition within a care-facility in Australia to deepen our understanding of this major life event. A focused ethnography was conducted, which included formal interviews with residents during their first 6 months of living in RAC. The findings provide an account of the participants’ views on acceptance, highlight the challenges of loss, and showcase the coping practices new residents used. This paper provides a type of report card for the sector, which reveals that there …

Membrane Fouling Dynamics And Flux Optimization In The Ultrafiltration Of Chlorella Sp. Mur 269 And Dunaliella Salina Cs 744/01, Victor Okorie Mkpuma, Mohadeseh Najafi, Javad Farahbakhsh, Masoumeh Zargar, Navid Reza Moheimani, Houda Ennaceri

Research outputs 2022 to 2026

Membrane filtration has emerged as a viable technique for microalgal dewatering. However, fouling constraints limit their large-scale implementation. In this research, the fouling patterns during ultrafiltration of Chlorella sp. and Dunaliella salina were investigated using both dead-end and crossflow filtration modules. Chlorella sp. filtration in the dead-end module revealed an initial flux of 72.02 L.m⁻².h⁻¹ in the first cycle, which rapidly decreased to 19.18 L.m⁻².h⁻¹ within 30 min. In the second and third cycles, the initial flux exhibited decreases of 23 % and 50 %, respectively. Chlorella sp. demonstrated lower fouling than D. salina …

Rapid Discrimination Of Mycobacterium Tuberculosis And Non-Tuberculous Mycobacteria Disease Via Interpretive Machine Learning Analysis Of Routine Laboratory Tests, Jia Wei Tang, Xue Song Xiong, Ting Ting Huang, Yu Lu Zhang, Lin Fei Yao, Wen Wen Zhang, Yun Yun Xie, Quan Fa Liang, Zhi Xuan Tan, Kun Jiang, Xin Liu, Liang Wang

Research outputs 2022 to 2026

Objectives Rapid discrimination of infections caused by Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacteria (NTM) is crucial in clinical settings. Despite overlapping clinical and radiological features, the two require markedly different therapeutic approaches and public health responses. Current laboratory methods are time-consuming and complex, underscoring the urgent need for a simple and efficient diagnostic tool to inform public health decision-making. Methods Demographic, haematological and biochemical data were collected from two hospitals in Jiangsu province, China, between December 2018 and October 2024. A total of 400 patients were included in the training cohort, with 66 patients used for external validation. Six machine …

Systematic Review And Meta-Analysis Of Microrna-7-5p Expression And Biological Significance In Head And Neck Squamous Cell Carcinoma, Rikki A.M. Brown, Michael Phillips, Andrew J. Woo, Omar Kujan, Stephanie Flukes, Louise N. Winteringham, Larissa C. Dymond, Fiona Wheeler, Brianna Pollock, Dianne J. Beveridge, Elena Denisenko, Peter J. Leedman

Research outputs 2022 to 2026

Background: Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy with poor clinical outcomes. microRNA-7-5p (miR-7-5p) has been described as both a tumour suppressor and an oncomiR depending on the tissue context, but its role in HNSCC remains unclear. This study aimed to clarify the clinical significance and biological function of miR-7-5p in HNSCC by integrating data from multiple sources. Methods: A systematic review of the literature was conducted to identify studies analysing miRNA expression in human head and neck tissues. A meta-analysis of individual patient data from Gene Expression Omnibus (GEO), ArrayExpress, and The Cancer Genome Atlas …

Temporal Eating Patterns And Ultra-Processed Food Consumption Assessed From Mobile Food Records Of Australian Adults, Janelle D. Healy, Satvinder S. Dhaliwal, Christina M. Pollard, Amelia J. Harray, Lauren Blekkenhorst, Fengqing Zhu, Deborah A. Kerr

Research outputs 2022 to 2026

Background/Objective: Temporal eating patterns and ultra-processed food (UPF) consumption have independently been associated with obesity and non-communicable diseases. Little is known about the temporal patterns of UPF consumption, as data is challenging to collect. Temporal data can be extracted from mobile food records (mFRs). The aim of this study was to identify the temporal eating patterns of those consuming UPFs using an mFR. Methods: A combined sample of 243 young (18–30 years) and 148 older (>30 years) adults completed a 4-day mFR. The time of eating was extracted from the mFR image metadata. UPFs were identified using the NOVA …

The Consequences Of Habitual Rumination, Expressive Suppression, And Perceived Stress On Mental And Physical Health Among Older Adults, Eyal Gringart, Rodrigo Becerra, Andrea Smith

Research outputs 2022 to 2026

Background/Objectives: The current study aimed to investigate whether habitual rumination, suppression, and perceived stress predict poor mental and physical health as well as well-being in a group of older adults (aged 50 to 80 years) from a non-clinical community sample. Methods: The current study comprised a cross-sectional survey design with online self-report measures. It was predicted that higher levels of rumination, suppression, and perceived stress would predict lower levels of general health as well as well-being, and heightened levels of depression and anxiety. Results: Findings from the study indicated that both rumination and perceived stress significantly predicted heightened anxiety, heightened …

Validation Of A Mind Diet Screener In Older Adults, Desarae A. Dempsey, Puja Agarwal, Shane Fernandez, Jared R. Brosch, Sujuan Gao, Daniel O. Clark, Frederick W. Unverzagt, Liana G. Apostolova, David G. Clark, Martin R. Farlow, Sunu Mathew, Sophia Wang, Michelle Quirke, Yolanda Graham-Dotson, Colette Blach, Leyla Schimmel, Rima Kaddurah-Daouk, Andrew J. Saykin, Shannon L. Risacher

Research outputs 2022 to 2026

Introduction: Higher adherence to the Mediterranean-DASH (Dietary Approaches to Stop Hypertension) Intervention for Neurodegenerative Delay (MIND) diet has been associated with reduced Alzheimer's disease (AD) risk. This study assessed the validity of a brief 15-item MIND diet screener compared to a comprehensive food frequency questionnaire (FFQ). Methods: The validity of an adapted MIND diet screener relative to the VioScreen FFQ was evaluated in 92 older adults from the Indiana Alzheimer's Disease Research Center (IADRC). Correlation coefficients and tertile-based classification statistics were used, and FFQ nutrient profiles were examined across screener-based MIND diet tertiles. Results: MIND diet scores from the screener …

A Five-Country Comparison Of Midwifery Students' Confidence In Facilitating Normal Labor And Birth, Juliet Wood, Jalana Lazar, Barbara Baranowska, Clare Davison, Debora Dole, Cindy L. Farley, Jane Fry, Maria Healy, Felicity Agwu Kalu, Urszula Tataj-Puzyna, Emma Ritchie, Maria Wegrzynowska

Research outputs 2022 to 2026

Introduction: Midwifery students need confidence in recognizing and supporting normal birth, the backbone of the midwifery professional role. Developing this confidence in the face of decreasing rates of physiological birth worldwide is a critical challenge. Midwife researchers from Australia, England, Northern Ireland, Poland, and the USA investigated midwifery student confidence for supporting normal birth and explored enhancing and detracting factors. Methods: A cross-sectional survey design was undertaken with 570 midwifery students at 8 academic midwifery programs across 5 countries The Student Confidence for Supporting Normal Birth Questionnaire with free text and Likert-type questions on a 1 (least influential) to 4 …

Rtn4ip1 Is Required For The Final Stages Of Mitochondrial Complex I Assembly And Coq Biosynthesis, Monika Oláhová, Rachel M Guerra, Jack J Collier, Juliana Heidler, Kyle Thompson, Chelsea R White, Paulina Castañeda-Tamez, Alfredo Cabrera-Orefice, Robert N Lightowlers, Zofia M A Chrzanowska-Lightowlers, Alexander Galkin, Ilka Wittig, David J Pagliarini, Robert W Taylor

2020-Current year OA Pubs

A biochemical deficiency of mitochondrial complex I (CI) underlies approximately 30% of cases of primary mitochondrial disease, yet the inventory of molecular machinery required for CI assembly remains incomplete. We previously characterised patients with isolated CI deficiency caused by segregating variants in RTN4IP1, a gene that encodes a mitochondrial NAD(P)H oxidoreductase. Here, we demonstrate that RTN4IP1 deficiency causes a CI assembly defect in both patient fibroblasts and knockout cells, and report that RTN4IP1 is a bona fide CI assembly factor. Complexome profiling revealed accumulation of unincorporated ND5-module and impaired N-module production. RTN4IP1 patient fibroblasts also exhibited defective coenzyme Q biosynthesis, …

Hemodynamic Characteristics Of Dilated Ascending Aorta In Patients With Bicuspid Aortic Valve, Yu Xia, Xuehuan Zhang, Shuai Zhu, Suwei Chen, Wentao Dong, Zhuo Chen, Nan Zhang, Jiafu Ou, Junming Zhu, Duanduan Chen, Tie Zheng

2020-Current year OA Pubs

BACKGROUND: The aim of this study is to investigate the influence of aortic diameter on hemodynamic environment characteristics in patient with the bicuspid aortic valve (BAV) and dilated ascending aorta (AAo).

METHOD: In this study, an MRI of one BAV patient with 4.5 cm AAo was collected and numerical model was constructed. Based on the images, three additional anatomical models were constructed with different AAo sizes of 4.0 cm, 5.0 cm and 5.5 cm respectively, while the size and the geometry of other parts were fixed. Then hemodynamics in these four models was simulated numerically and the flow patterns and …

High Prevalence Of Abnormal Baseline Lung Function In Pediatric And Young Adult Hematopoietic Stem Cell Transplant Recipients: A Report From The Transpire Study, Adam Lane, Sara Katherine Loveless, Lauren Strecker, Kelly E Lake, Kasiani C Myers, Christopher Towe, Jessica Patti, Laura L Walkup, Kathryn A Wikenheiser-Brokamp, Margaret L Macmillan, Philip Lacher, Tamara Griffin, Merve Tekman, Gabriel Salinas Cisneros, Kevin Wu, Matthew S Zinter, Fernando A Urrego, K Scott Baker, Matthew F Abts, Sheri Ballard, Jason L Freedman, Alexander Caraballo, Lisa R Young, Maureen B Josephson, Julian L Allen, Devaney M Camburn, Erin E Doherty, Mashid Sababi Azamian, Martha Arredondo, Manuel Silva-Carmona, Leslie E Lehmann, Wai Wong, Jonathan M Gaffin, William Mcalpine, Mona Li, Samuel B Goldfarb, Jason C Woods, Stella M Davies

Faculty, Staff and Students Publications

Background: Pulmonary complications are a major cause of morbidity and mortality in pediatric and young adult hematopoietic stem cell transplant (HSCT) recipients. The impact of preexisting lung dysfunction on posttransplant outcomes remains understudied.

Methods: In a multi-institutional prospective cohort of 444 patients (≤24 years) undergoing allogeneic HSCT at eight centers, baseline lung function was categorized as normal or abnormal using clinical history, imaging, pulmonary function tests (PFTs), and pulmonologist review. Spirometry and diffusion capacity were assessed at baseline, Day 100, 1 year, and 2 years post-HSCT.

Results: Baseline pulmonary dysfunction was present in 224 patients (50.4%), including impaired spirometry (46.4%), …

Transdiagnostic Correlates Of Family Accommodation In Anxious Youth, Hannah N Sansone, Daphne M Ayton, Amanda Palo, Abigail E Candelari, Wayne K Goodman, Andrew G Guzick, Eric A Storch

Faculty, Staff and Students Publications

Anxiety disorders are common in children and cause significant impairment. Family accommodation, which refers to behavioral changes that family members make to temporarily alleviate a child’s anxiety, has been linked to child anxiety symptom severity. Although emotional vulnerabilities for anxiety such as emotion dysregulation, anxiety sensitivity, and distress intolerance have been associated with family accommodation, research concerning the relationship between these constructs among anxious youth is limited. We hypothesized that these variables would be uniquely and positively associated with family accommodation and would moderate the relationship between anxiety symptom severity and family accommodation. Treatment-seeking child–parent dyads (N = 90; …

Correction: Ron Signalling Promotes Therapeutic Resistance In Esr1 Mutant Breast Cancer, Sarah K Herzog, David G Edwards, Hangqing Lin, Thomas L Gonzalez, Sandra L Grimm, Cristian Coarfa, Doug W Chan, Beom-Jun Kim, Jean-Paul De La O, Matthew J Ellis, Dan Liu, Shunqiang Li, Alana L Welm, Suzanne A W Fuqua

Faculty, Staff and Students Publications

No abstract provided.

Updated Cross-Sectional Prevalence Data For Lichen Sclerosus In The All-Of-Us Database: Implications For Current Routine Genital Skin Examination Practices, Daniel P Friedmann, Mary Fitzgibbon, Michelle B Tarbox, Theodore Rosen

Faculty, Staff and Students Publications

No abstract provided.