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Ten Commandments In The Public Square And Public Schools, Mark David Hall, Andrea Picciotti-Bayer Oct 2025

Ten Commandments In The Public Square And Public Schools, Mark David Hall, Andrea Picciotti-Bayer

William & Mary Bill of Rights Journal

The Ten Commandments are of paramount importance to the Jewish and Christian faiths, and they are viewed by many as a source of Western law. In America, they have been (and are) taught in churches and synagogues, and throughout much of this nation’s history they have been taught by parents, tutors, and teachers in private and public schools. They are regularly displayed in courthouses and statehouse grounds, and some states have desired to display them in public schools. Predictably, those who would scrub religion from the public square have argued that Ten Commandment displays on public property violate the First …


Regulating Deception To Protect Democracy: Global Election Misinformation Regulations Analyzed Under U.S. First Amendment Doctrine, Stephanie Hoke Oct 2025

Regulating Deception To Protect Democracy: Global Election Misinformation Regulations Analyzed Under U.S. First Amendment Doctrine, Stephanie Hoke

William & Mary Bill of Rights Journal

This Note argues that the marketplace of ideas may not always be a workable theory for the election misinformation that pervades social media platforms. Social media is a unique medium because it does not have the same safeguards as television, radio, and newspapers that are used to filter out false claims and information. Due to the lack of safeguards and the algorithms that promote misinformed posts, social media platforms provide a thriving environment for election misinformation. In addition, the presence of online “echo chambers” and the speed at which misinformation can spread calls for some form of government regulation. In …


The 10-Year Functional Outcome Of Ponseti Treatment Of Idiopathic And Arthrogrypotic Clubfeet With An Age-Matched Control, Chris Church, Nicole Wang, Stephanie Butler, Jose J Salazar-Torres, John Henley, Freeman Miller, Nancy Carlin, Maureen Donohoe, L Reid Nichols Oct 2025

The 10-Year Functional Outcome Of Ponseti Treatment Of Idiopathic And Arthrogrypotic Clubfeet With An Age-Matched Control, Chris Church, Nicole Wang, Stephanie Butler, Jose J Salazar-Torres, John Henley, Freeman Miller, Nancy Carlin, Maureen Donohoe, L Reid Nichols

Faculty and Staff Publications

Background: The Ponseti method is accepted as an effective primary conservative treatment for idiopathic clubfoot (IC) using serial casting, percutaneous Achilles tenotomy, and prolonged bracing. The outcomes of its use in treating rigid clubfoot in arthrogryposis are unclear. This study assesses the outcomes of the Ponseti method in children with IC and arthrogrypotic clubfoot at an average age of 10 years.

Methods: Outcomes of the Ponseti method were retrospectively studied in ambulatory children ages 8.0 to 12.9 years in the gait lab between 2004 and 2024. Children were excluded due to the presence of nonidiopathic or nonarthrogryposis-related clubfoot and history …


Accreditation Standards Must Protect Trainees: Creating Ethical Fellowship Programs, Anna D Goff, Ryan J Dougherty, Joelle Robertson-Preidler Oct 2025

Accreditation Standards Must Protect Trainees: Creating Ethical Fellowship Programs, Anna D Goff, Ryan J Dougherty, Joelle Robertson-Preidler

Faculty and Staff Publications

No abstract provided.


Theoretical Investigation And Practical Validation Of Ai Based Fault Detection In Bjt Amplifier Circuits, Sameh O. Abdellatif, Kyrillos Selim, Ahmad Alaa, Ola Hassan Oct 2025

Theoretical Investigation And Practical Validation Of Ai Based Fault Detection In Bjt Amplifier Circuits, Sameh O. Abdellatif, Kyrillos Selim, Ahmad Alaa, Ola Hassan

Electrical Engineering

Analog circuits are essential to electronic systems due to their variety of critical functions. Catastrophic faults, such as short- and open-circuit faults, can stop the circuit from functioning. Meanwhile, parametric faults such as drift due to temperature fluctuations, noise in components, and power supply issues cause the circuit to operate beyond its range. Such faults can harm the circuit and its constituent parts. Therefore, it is crucial to identify and address the issues brought on by these faults. Common traditional fault diagnosis methods that rely on manual testing and visual assessment are lacking in complex electronic systems and faults. Such …


Advancing Self-Powered Continuous Glucose Monitoring: A Comprehensive Simulation Of Sensor-On-Chip Development And Analog Interface Circuit Design, Sameh O. Abdellatif, Kyrillos Selim, Adham Farag Oct 2025

Advancing Self-Powered Continuous Glucose Monitoring: A Comprehensive Simulation Of Sensor-On-Chip Development And Analog Interface Circuit Design, Sameh O. Abdellatif, Kyrillos Selim, Adham Farag

Electrical Engineering

The advent of continuous glucose monitoring (CGM)technology has revolutionized diabetes management, facilitating real-time blood glucose assessment that optimizes insulin therapy and dietary modifications, thereby significantly enhancing patient outcomes. This study presents comprehensive modeling, simulation, and integration of a continuous glucose monitoring system on-chip, featuring an optimized electrochemical glucose sensor equippedwith dual-energy harvesting units. In the assessment of glucose sensor performance at optimized conditions, the simulated characteristic curve showed a sensitivity of 8063 mA. m mol−1 at a working electrode width of 90 μm and height of 200 μm. The developed system incorporates a battery managementsystem that effectively bridges the harvested …


Inductorless Cascaded Low-Power Dc-Dc Converter: Optimizing Performance Metrics Through Machine Learning Techniques, Ahmed Khaled, Sameh O. Abdellatif Oct 2025

Inductorless Cascaded Low-Power Dc-Dc Converter: Optimizing Performance Metrics Through Machine Learning Techniques, Ahmed Khaled, Sameh O. Abdellatif

Electrical Engineering

This study presents a groundbreaking methodology for optimizing the operational efficiency of a three-stage boost DC-DC cascaded converter through the application of a Random Forest(RF) machine learning algorithm. A novel figure of merit is meticulously formulated to quantitatively evaluate the converter’s performance, focusing on critical metrics such as power conversion efficiency, output DC ripple levels, and response time. The Random Forest model is trained on a comprehensive dataset encompassing a wide range of resistive and capacitive design parameters, with the figure of merit serving as the output indicator. Rigorous simulations and analyses demonstrate that the integration of LM741 operational amplifiers …


University Of Baltimore Law Review, Volume 54, Issue 2, Fall 2025 Oct 2025

University Of Baltimore Law Review, Volume 54, Issue 2, Fall 2025

University of Baltimore Law Review

No abstract provided.


Woman, Motherhood, And Home: Grappling With Gendered Dwelling, Pamela Joy M. Capistrano Oct 2025

Woman, Motherhood, And Home: Grappling With Gendered Dwelling, Pamela Joy M. Capistrano

Philosophy Department Faculty Publications

Though ostensibly gender neutral, the word “home” carries with it the baggage of gender, particularly womanhood and motherhood. In English, for instance, “homemaking” is synonymous with “housewifery;” in Filipino, the mother is described as ilaw ng tahanan (“light of the home”). Housing, as well, has a similar neutral connotation; yet, when we consider the impact of urban housing crises, women are disproportionately affected. In this paper, I want to grapple with the broader implications of the gendered baggage of the idea of “home,” its impact on individuals, on how we conceive of houses, homes, and dwellings, and ultimately its impact …


Exploring Dynamics Of Nature’S Raincoat: Comparing How Nano-Scale Silk Fibers Produced By Dryland And Tropical Species Of Webspinning Insects Interact With Water, Richard P. Barber Jr, Emily A. Arias, Andrew M. Schatz, Aidan Kaneski, Janice Edgerly-Rooks Oct 2025

Exploring Dynamics Of Nature’S Raincoat: Comparing How Nano-Scale Silk Fibers Produced By Dryland And Tropical Species Of Webspinning Insects Interact With Water, Richard P. Barber Jr, Emily A. Arias, Andrew M. Schatz, Aidan Kaneski, Janice Edgerly-Rooks

Biology

Embiopterans are reliant on silk for protection and produce the finest silk fibers known in nature. This report compares silk–water interactions for four species representing two different lifestyles: two tropical arboreal species that feed on lichens on bark and two detritivores from arid regions that typically live in leaf litter and underground. Water droplets placed on spun silk transformed the fibrous top layer to a film. Arboreal embiopterans spun a denser silk covering than did the detritivores. The films that formed after exposure to water were also denser for the arboreal species. A possible underlying cause for the difference between …


The Intersection Of Managing, Leading, And Coaching: A New Discipline For Management Education, Maureen L. Mackenzie-Ruppel Ph.D., Phr, Capm, Icf-Pcc Oct 2025

The Intersection Of Managing, Leading, And Coaching: A New Discipline For Management Education, Maureen L. Mackenzie-Ruppel Ph.D., Phr, Capm, Icf-Pcc

Business: Faculty Presentations

Faculty must ensure that management education remains cutting edge and relevant to the needs of organizational leaders and to students’ academic and professional goals. This paper reports on a multi-phase research agenda that included in-depth interviews with the primary stakeholders of business education: (1) senior leaders/employers, (2) business faculty, and (3) MBA graduates who are now working professionals. The results report on potential benefits of integrating coaching skills, theories, and knowledge into management education.


Task Prioritization In Concurrent Speaking And Visuomotor Tasks In Younger And Older Adults, Naomi Wynn Oct 2025

Task Prioritization In Concurrent Speaking And Visuomotor Tasks In Younger And Older Adults, Naomi Wynn

Theses and Dissertations

The present study examined the ability of younger and older adults to prioritize one task over another under divided attention conditions. The speech task involved the repetition of sentences that included specific vowel targets, and the non-speech task was a visuomotor pursuit rotor task which required tracking a moving target on a computer. The participants were twenty young adults between the ages of 18 and 30 and twenty older adults above the age of 60. They performed each task on its own and both tasks concurrently, prioritizing one or the other task. Audio recordings were analyzed with software to extract …


Speech Motor Learning In Divided And Undivided Attention Conditions, Garrett Barnes Oct 2025

Speech Motor Learning In Divided And Undivided Attention Conditions, Garrett Barnes

Theses and Dissertations

This study investigated the effect of dual tasking on speech motor learning. Forty young adult participants (20 male, 20 female) practiced speaking nonsense words containing non-English consonant clusters. Half of the participants practiced the words while also completing a shape identification task. After practice, the two groups produced the words in a retention task both with and without the shape identification task. They returned the next day to produce the words again with and without the shape identification task. Acoustic analysis of the consonant cluster and word duration was used as an index of motor learning. Statistical analysis revealed that …


David Tall: Some Personal Reflections, Matthew Inglis Oct 2025

David Tall: Some Personal Reflections, Matthew Inglis

The Mathematics Enthusiast

Matthew Inglis’s memories of David Tall.


A Tribute To The Life And Work Of David Tall, Sepideh Stewart Oct 2025

A Tribute To The Life And Work Of David Tall, Sepideh Stewart

The Mathematics Enthusiast

David Tall was my academic grandfather, a wonderful mentor, and a brilliant mathematics educator. He earned two PhD degrees in mathematics and mathematics education. His edited book, Advanced Mathematical Thinking, and many of his publications that followed carved the path to shape many advances in mathematics education. His work on the framework of the three worlds of mathematics resonated well with mathematicians, giving them a language to express their thought processes as they reflected on their teaching and research. His latest framework, A Meaningful Long-term Framework for Mathematical Thinking, extended his ideas further and captured more on the complexity of …


Memories Of Simon Goodchild, Paul Ernest Oct 2025

Memories Of Simon Goodchild, Paul Ernest

The Mathematics Enthusiast

Paul Ernest’s recollections of Simon Goodchild.


First-Year University Students’ Mathematics Capital And Identities, Paola Valero, Lisa Österling, Nhu Truong, Anna Danielsson, Bruna Nunes, Maria Berge Oct 2025

First-Year University Students’ Mathematics Capital And Identities, Paola Valero, Lisa Österling, Nhu Truong, Anna Danielsson, Bruna Nunes, Maria Berge

The Mathematics Enthusiast

Based on a survey of 150 respondents and 16 timeline interviews with first-year university mathematics students in Sweden, we explore how the material resources and conditions available to them —mathematics capital— connect to their mathematical identities. We found that mathematics capital has bearing on how early in life students start to consider doing mathematics. We also found individually different trajectories among students with low mathematics capital into university mathematics. The study expands both existing theoretical and methodological ways of researching the material bearings of identity and opens up for new ways of understanding and exploring the conditions that may facilitate …


Carbon Footprint Of Carrots In Western Australia, Christophe D'Abbadie, Saloomeh Akbari, Sang Ravindran Oct 2025

Carbon Footprint Of Carrots In Western Australia, Christophe D'Abbadie, Saloomeh Akbari, Sang Ravindran

Horticulture research reports

This report presents the findings of a comprehensive carbon accounting study conducted on carrot production in the Myalup area of Western Australia.

The study reveals that carrot emissions are approximately 81 kg CO2e per tonne of carrot sold from the April harvest and 76 kg CO2e per tonne from the October harvest, when using rejected carrots for other economic uses. These figures represent competitive emissions intensities compared to international benchmarks.

Key findings include:

  • Yield improvement is the primary driver for emissions reduction: Increasing productivity, without proportional input increases, offers the most effective pathway to lower emissions’ intensity while improving economic …


To Calmly Rest: Frances E. W. Harper’S Sensational Black Disability Poetics, Vivian Delchamps Wolf Oct 2025

To Calmly Rest: Frances E. W. Harper’S Sensational Black Disability Poetics, Vivian Delchamps Wolf

English and Creative Writing | Faculty Scholarship

This article argues that Frances E. W. Harper’s poetics generate a broad understanding of disability, one that accounts for entanglements of race and structural debilitation. Drawing on Black disability studies, a field that examines intertwining oppressions of ableism and racism, the article shows how Harper’s poetry challenges expectations that Black people perform strength and resilience while they survive debilitating oppressive systems. Her work resists the reductive association of Blackness with deficiency while refusing to ignore the material effects of racial capitalism, which has long extracted from Black bodies while denying them care and rest. Centering pain and fatigue not only …


Bioinformatic Analysis Of Pogz Variants In Relation To White Sutton Syndrome, Hannah Rollins Oct 2025

Bioinformatic Analysis Of Pogz Variants In Relation To White Sutton Syndrome, Hannah Rollins

Theses

White-Sutton syndrome (WHSUS) is a rare neurodevelopmental disorder caused by mutations in the Pogo Transposable Element with ZNF Domain (POGZ) gene, which encodes pogo-transposable element with ZNF domain, a chromatin regulator essential for proper mitotic progression and DNA repair. This study uses a bioinformatic framework to evaluate the structural and functional impact of missense mutations in the conserved amino acid region (positions 500–800) of the POGZ protein. Protein modeling, variant effect prediction, conservation analysis, and molecular dynamics simulations were employed to gain an understanding of the effects of POGZ missense mutations on protein structure and movement with specific emphasis on …


International Headache Society Evidence-Based Guidelines On The Use Of Non-Invasive Neuromodulation Devices For The Acute And Preventive Treatment Of Migraine, Hsiangkuo Yuan, Serena L. Orr, Mohammad A. M. Al-Karagholi, Messoud Ashina, Fred Cohen, Hans-Christoph Diener, David W. Dodick, Rigmor Højland Jensen, Michael J. Marmura, Daniele Martinelli, Manjit S. Matharu, Anja S. Petersen, Patricia Pozo-Rosich, Simona Sacco, Lucy Simmonds, Cristina Tassorelli, Stewart J. Tepper, Gisela M. Terwindt, Shuu-Jiun Wang, Jiunn-Tyng Yeh, Stephen D. Silberstein Oct 2025

International Headache Society Evidence-Based Guidelines On The Use Of Non-Invasive Neuromodulation Devices For The Acute And Preventive Treatment Of Migraine, Hsiangkuo Yuan, Serena L. Orr, Mohammad A. M. Al-Karagholi, Messoud Ashina, Fred Cohen, Hans-Christoph Diener, David W. Dodick, Rigmor Højland Jensen, Michael J. Marmura, Daniele Martinelli, Manjit S. Matharu, Anja S. Petersen, Patricia Pozo-Rosich, Simona Sacco, Lucy Simmonds, Cristina Tassorelli, Stewart J. Tepper, Gisela M. Terwindt, Shuu-Jiun Wang, Jiunn-Tyng Yeh, Stephen D. Silberstein

Department of Jefferson Headache Center Papers and Presentations

ObjectiveTo develop evidence-based clinical practice guidelines for non-invasive neuromodulation devices in acute and preventive migraine treatment.MethodsA systematic review was conducted across six databases from 1946 to April 2025. Randomized controlled trials evaluating Food and Drug Administration-cleared or Conformité Européenne (CE)-marked non-invasive neuromodulation devices were included. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology, and recommendations were developed through consensus following GRADE Evidence-to-Decision frameworks. The working group comprised 15 senior members and six junior members.ResultsFrom 1536 initial records, 15 studies met the inclusion criteria and were finally used to develop evidence-based recommendations. …


District Vulnerability Index For Pakistan (Dvip): Harnessing Multisectoral Data To Inform Equitable Policy And Climate Action, Population Council Oct 2025

District Vulnerability Index For Pakistan (Dvip): Harnessing Multisectoral Data To Inform Equitable Policy And Climate Action, Population Council

Climate and Environmental Changes

Pakistan’s highly heterogeneous population faces significant development challenges, including unequal resource distribution and disparities in access to services, which create varying levels of vulnerability across communities. While existing studies have primarily examined vulnerability through climate, economic, or other disaster lenses, they often overlook underlying structural and systemic factors. This study aims to address that gap by developing an index that incorporates domains of vulnerability typically underrepresented in analyses of Pakistan.


Science, Sand, And Faith: Exploring Competing Explanations Of Coconino Sandstone, Emily Schneider Oct 2025

Science, Sand, And Faith: Exploring Competing Explanations Of Coconino Sandstone, Emily Schneider

Science, Faith, and Origins

The Coconino Sandstone, a Permian rock layer found in the western United States, is a topic of debate among standard geologists and flood geologists. The conventional geological interpretation claims the sandstone is an eolian deposit, meaning the sediments were deposited by wind (McKee, 1979; Selley, 1968). In their view, key elements of the sandstone, like the cross-stratified beds, high degree of frosting, and the animal trackways, confirm the Coconino’s similarity to modern eolian dunes (McKee, 1979). As this rock layer is sandwiched between layers typically interpreted by flood geologists as being deposited during the flood, the idea that the Coconino …


Issue Iii: Sátya, Devin Hecht, Sofia Farinas, Sherry Li, Breeze Hong, Abby Murphy, Alex Mcintosh, Caitlyn Brabo Oct 2025

Issue Iii: Sátya, Devin Hecht, Sofia Farinas, Sherry Li, Breeze Hong, Abby Murphy, Alex Mcintosh, Caitlyn Brabo

Sátya

For the fall 2024 edition of Sátya, we have chosen seven submissions from students across the Five Colleges whose writing we felt best embodied the aims of our journal—to focus on interdisciplinary works which push the boundaries of philosophy. Not only did these students produce impressive logical arguments and concise reconstructions, but each and every paper that we chose was distinguished in its accomplishment of producing work that is both original and creative in its aims. Our hope is to create a space for innovative work to be upheld; to create a dialogue that interrogates commonly held conceptions of …


Research On Identification And Evaluation Method Of Medical Experts' Expertise Domains In Online Health Community Based On Knowledge Graph, Yunjiang Xi, Qian Zhang, Man Li, Juan Yu Oct 2025

Research On Identification And Evaluation Method Of Medical Experts' Expertise Domains In Online Health Community Based On Knowledge Graph, Yunjiang Xi, Qian Zhang, Man Li, Juan Yu

Journal of Scientific Information Research

[Purpose/significance] This study aims to identify the expertise domains of medical experts, and evaluates their domain levels to provide a basis for community expert recommendation.

[Method/process] This study utilized the improved OneRel model to structure community historical Q&A into entity relation triples. Then used the knowledge graph triples to test the consistency between the medical knowledge in the community Q&A and the domain knowledge, and finally obtained the doctor's domain levels by aggregating in each expertise domain.

[Result/conclusion] Using the data example from xywy.com website, 214 doctors in the community were ranked in terms of their average level of expertise …


Closing The Loop On Textile Waste: Policy, Technology, And Consumer Behavior In Sustainable Fashion, Anthony Amotoe-Bondzie Oct 2025

Closing The Loop On Textile Waste: Policy, Technology, And Consumer Behavior In Sustainable Fashion, Anthony Amotoe-Bondzie

Collected Student Papers

Textile waste has become one of the most visible consequences of the fashion industry’s linear production and consumption model, where materials are rapidly extracted, transformed, consumed, and discarded. This paper critically examines how sustainable fashion can move beyond isolated recycling efforts toward a more integrated circular economy framework. Rather than treating textile waste as only an end-of-life problem, the study analyzes it as a systems issue shaped by overproduction, weak product design, limited recovery infrastructure, fragmented regulation, and consumer habits that normalize short garment lifespans. The paper argues that closing the loop on textile waste requires coordinated interventions across policy, …


Humanized Mouse Models For Type 1 Diabetes., David V. Serreze, Marissa Tousey-Pfarrer, Jeremy Racine Oct 2025

Humanized Mouse Models For Type 1 Diabetes., David V. Serreze, Marissa Tousey-Pfarrer, Jeremy Racine

Faculty Research 2025

T cell-mediated autoimmune type 1 diabetes (T1D) is under complex polygenic control in both humans and the NOD mouse model. However, in both species, particular major histocompatibility complex (MHC; designated HLA in humans) haplotypes provide the primary T1D risk factor. Both MHC/HLA class I and II variants interactively contribute to T1D by respectively driving autoreactive CD8 and CD4 T cell responses that cooperatively destroy insulin-producing pancreatic β cells. While NOD mice have provided important insights to the pathogenic basis of T1D, the model has so far provided only a limited means to identify possible clinically translatable disease intervention approaches. This …


Advancing The Science Of Genomic Learning Healthcare Systems., Teri A Manolio, Renee Rider, Carol J Bult, Rex L Chisholm, Patricia A Deverka, Geoffrey S Ginsburg, Eric D Green, Gail P Jarvik, George A Mensah, Jahnavi Narula, Erin M Ramos, Mary V Relling, Dan M Roden, Robb Rowley, Noura S Abul-Husn, Adam H Buchanan, Christopher G Chute, Guilherme Del Fiol, Gai Elhanan, Susanne B Haga, Rizwan Hamid, Carol R Horowitz, Peter J Hulick, Cynthia A James, Janina M Jeff, Bruce Korf, Latrice Landry, Deven Mcgraw, Howard L Mcleod, Nancy J Mendelsohn, Travis Osterman, Casey Overby Taylor, Daryl Pritchard, Heidi L Rehm, Krystal S Tsosie, Jason L Vassy, Karriem Watson, Ken Wiley, Marc S Williams Oct 2025

Advancing The Science Of Genomic Learning Healthcare Systems., Teri A Manolio, Renee Rider, Carol J Bult, Rex L Chisholm, Patricia A Deverka, Geoffrey S Ginsburg, Eric D Green, Gail P Jarvik, George A Mensah, Jahnavi Narula, Erin M Ramos, Mary V Relling, Dan M Roden, Robb Rowley, Noura S Abul-Husn, Adam H Buchanan, Christopher G Chute, Guilherme Del Fiol, Gai Elhanan, Susanne B Haga, Rizwan Hamid, Carol R Horowitz, Peter J Hulick, Cynthia A James, Janina M Jeff, Bruce Korf, Latrice Landry, Deven Mcgraw, Howard L Mcleod, Nancy J Mendelsohn, Travis Osterman, Casey Overby Taylor, Daryl Pritchard, Heidi L Rehm, Krystal S Tsosie, Jason L Vassy, Karriem Watson, Ken Wiley, Marc S Williams

Faculty Research 2025

INTRODUCTION: Identifying key characteristics of exemplar genomic learning healthcare systems (gLHS) and knowledge gaps that can be explored by collaboration among them is likely to accelerate the sharing of best practices and generation of evidence that informs the use of genomics in clinical care.

METHODS: Deliberations of an expert group convened by the National Human Genome Research Institute (NHGRI) supplemented by relevant literature.

RESULTS: Recent advances in genomic data standardization, automated clinical decision support, increased interoperability, and improved genomic technologies have enabled the development of several robust gLHS. They remain concentrated in major academic centers, however, and operate largely independently. …


Evaluation Of Hippocampal Dlgap2 Overexpression On Cognition, Synaptic Function, And Dendritic Spine Structure In A Translationally Relevant Ad Mouse Model., Andrew R Ouellette, Kristen M S O'Connell, Catherine Kaczorowski Oct 2025

Evaluation Of Hippocampal Dlgap2 Overexpression On Cognition, Synaptic Function, And Dendritic Spine Structure In A Translationally Relevant Ad Mouse Model., Andrew R Ouellette, Kristen M S O'Connell, Catherine Kaczorowski

Faculty Research 2025

INTRODUCTION: Developing effective therapeutics for Alzheimer's disease (AD) requires a better understanding of the molecular drivers of the disease. Our previous work nominated DLGAP2 as a modifier of age-related cognitive decline and risk for AD. We tested the hypothesis that overexpression of DLGAP2 in the hippocampus would protect against cognitive and synaptic deficits in a susceptible F1 5XFAD model.

METHODS: DLGAP2 was overexpressed in the hippocampus of F1 hybrid 5XFAD and non-transgenic littermates using a viral approach. Cognitive function, electrophysiological properties, and dendritic spine morphology were assessed at 6 and 14 months of age.

RESULTS: DLGAP2 overexpression impaired synaptic plasticity …


Stress On Healthcare Workers During The Covid-19 Pandemic, Tim Frink Oct 2025

Stress On Healthcare Workers During The Covid-19 Pandemic, Tim Frink

Expo Student Presentations

2025 Fall Expo Online Poster Presentation

  • Health Sciences & Health Professions
  • Social & Behavioral Sciences