Digital Commons Network^™

Whipple Disease Initial Presentation As Supraclavicular Lymphadenopathy In A Patient With Rheumatoid Arthritis: A Diagnostic Challenge, Sara E Amin, Swati Gite, Audrey Wanger, Violeta Chavez, Jacob Armstrong, Beenu Thakral, Patricia Navarro, Jennifer Makhoul, Amer Wahed, Navneet Narula, Karan Saluja

Faculty, Staff and Student Publications

Whipple disease is a rare systemic disease caused by Tropheryma whipplei. It can present with a wide range of nonspecific symptoms that might overlap with underlying medical conditions, posing a diagnostic challenge. We present a 61-year-old man with a past medical history of rheumatoid arthritis and chronic inflammatory demyelinating polyneuropathy, who presented with persistent leukocytosis and supraclavicular lymphadenopathy. A positron emission tomography scan revealed hypermetabolic activity in the supraclavicular, abdominal, and pelvic lymph nodes along with a myocardial hypermetabolic lesion, concerning a lymphoproliferative disorder versus sarcoidosis. A supraclavicular lymph node excisional biopsy revealed complete architectural effacement by a diffuse foamy …

Developing Consensus For A More Provider-Friendly Next-Generation Sequencing Molecular Biomarker Report: A Joint Consensus Recommendation Of The Association For Molecular Pathology And College Of American Pathologists, Jane Gibson, Hanadi El Achi, Dana Altenburger, Noah Brown, Amy S Clark, Joshua Coleman, Rajyasree Emmadi, Amber M Fussell, Meera Hameed, Danielle Jordan, Jennifer Laudadio, Anthony Provenzano, Robyn L Temple-Smolkin, Christopher G Suciu

Faculty, Staff and Student Publications

Despite the increasing availability of next-generation sequencing (NGS) gene panel analysis for cancers, published reports suggest underutilization of testing, citing the shortage of credentialed professionals available to assist with the interpretation of test results among the key barriers. Obtaining a multidisciplinary consensus regarding a shared best practice NGS molecular biomarker reporting section template may facilitate introduction and/or increased testing for institutions that adopt similar report structures by improving report effectiveness and efficiency for both health care providers and laboratory professionals, leading to improved patient care. To address this challenge, the Association for Molecular Pathology convened a multidisciplinary collaborative expert working …

Impact Of Propofol Or Sevoflurane On The Renoprotective Effect Of Remote Ischaemic Preconditioning In Cardiac Surgery: The Hypnorenalrip Randomised Clinical Trial, Raphael Weiss

Faculty, Staff and Student Publications

Background: Remote ischaemic preconditioning (RIPC) might reduce acute kidney injury after cardiac surgery. Protective effects appear to be restricted to patients with early and transient increases in two cell cycle arrest markers, tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7), in urine. Studies suggest that propofol can attenuate the preconditioning effect on the myocardium. This study investigated whether propofol diminishes the renoprotective effect associated with the early transient increases in TIMP-2 and IGFBP7.

Methods: This was a single-centre, prospective randomised double-blind 2×2 factorial clinical trial of high-risk patients undergoing cardiac surgery. Patients were randomised to receive …

Practical Effectiveness Of Large Language Models In Assisting Landscape Architects In Plant Selection, Paul Gardner

All Graduate Theses and Dissertations, Fall 2023 to Present

Artificial intelligence (AI) is rapidly transforming many industries, but its role in landscape architecture remains relatively unexplored. This study examines how AI, specifically GPT-4, can assist landscape architects in selecting plants for projects. By comparing AI-generated plant lists to those that human experts created, the research evaluates Accuracy, Suitability, Availability, Aesthetics, and Professional Usability.

The results show that AI-generated plant lists were highly efficient, accurately matching site conditions and improving plant availability while significantly reducing selection time. However, human expertise was essential for ensuring aesthetic quality and design intent. While AI can serve as a powerful tool for streamlining plant …

Improvisation Of Mands Using Augmentative And Alternative Communication, Lauren Decker

All Graduate Theses and Dissertations, Fall 2023 to Present

Research shows that young children who use pictures to communicate can use colors, shapes, and functions of items to request when the specific picture of the item is not available. This problem-solving skill is called improvisation, which this study taught to a preschool aged participant with communication delays. A four-year-old preschool student was able to make these requests with basic colors, shapes, and three function pictures. They also were able to make these requests for items not taught to them in different settings. This suggests that improvisation training can be successfully implemented with preschool aged children with communication delays and …

An Evaluation Of Virtual Reality Modeling To Improve Accuracy Of Physical Education Skills In Teenage Students With Disabilities, Kristen Lee

All Graduate Theses and Dissertations, Fall 2023 to Present

Virtual Reality (VR) technology is becoming more common in schools, especially for teaching and training. In this study, researchers explored how VR can help teenagers with disabilities improve their physical education skills, specifically push-ups, lunges, and jumping jacks. The participants all showed an increase in their skills and reached a high level of accuracy on every skill. The results showed that adding feedback was also necessary for some participants. Additionally, participants enjoyed using the VR equipment and showed high levels of happiness throughout the study. These findings suggested that using VR technology can be an effective way to support teenagers …

Understanding Impact Of Starter Culture Blends On The Ph Variation In Cheddar Cheese During Early Aging, Samuel J. Clarke

All Graduate Theses and Dissertations, Fall 2023 to Present

Consumer expectations govern what is acceptable when it comes to the flavor, texture, and color of the cheese. These quality attributes of cheese are all influenced by the pH of the cheese which is in turn controlled by the acid production of the starter lactic acid bacteria (SLAB) used to make cheese. Whatever the final pH of the cheese is, is what determines the quality of the cheese. Unfortunately, there are some Cheddar cheese manufacturers that have observed pH variation during the early aging of their cheeses. We hypothesize that the addition of thermophilic, fast-acid producing bacteria, like Streptococcus thermophilus …

Enabling Scalable Camera-Based Streamflow Monitoring With Serverless Cloud Computing, Sajan Neupane

All Graduate Theses and Dissertations, Fall 2023 to Present

This thesis introduces a modern and automated method for monitoring rivers and streams using cameras and cloud-based software tools. Traditional monitoring methods often rely on sensors placed directly in the water, which can be expensive, hard to install, and difficult to maintain, especially in remote or rough terrain. In contrast, this approach uses cameras to observe water flow from a distance, offering a safer and more cost-effective alternative. However, camera systems come with their own challenges, such as collecting large amounts of image data, transferring it reliably from the field, and analyzing it quickly enough to be useful. This research …

Golden Eagle Predation Of Greater Sage-Grouse On Diamond Mountain Plateau, Victoria E. Thorpe

All Graduate Theses and Dissertations, Fall 2023 to Present

Predation and the perceived risk of predation can have major impacts on prey populations. Golden Eagles are considered one of the main predators of adult greater sage-grouse. Sage-grouse populations have been declining for decades throughout the West and wildlife managers are concerned about the impacts of golden eagles on sage-grouse. We investigated the nonconsumptive effects of golden eagles on sage-grouse by conducting observational surveys for golden eagles, sage-grouse, and other predators at sage-grouse lek sites near Vernal, Utah during the sage-grouse breeding season from 2022–2024. Additionally, we examined the prevalence of sage-grouse in golden eagle diet using DNA metabarcoding of …

Lagomorphs, Ungulates, And Predation: Exploring Interactions And Quantifying The Effect Of Lagomorph Herbivory In Rangelands, Shantell Marie Garrett

All Graduate Theses and Dissertations, Fall 2023 to Present

Rangelands are expansive ecosystems that make up more than 30% of the total surface land area in the contiguous United States. In the west, they are typically categorized as shrublands, grasslands or deserts with low precipitation. The vegetation communities consist largely of grasses and forbs and are thus widely used for livestock grazing. Despite their barren appearance, rangelands are diverse ecosystems that are home to a wide breadth of species.

The Henry Mountains, located in south central Utah, is one example of this system type. With their inspiring red-rock mesas and towering plateaus, this public land, managed by the Bureau …

Using Luminescence Of Quartz Temper From Archaeological Pottery To Infer Wildfire Intensity In The Southwestern Us, Brooklyn D. Dib

All Graduate Theses and Dissertations, Fall 2023 to Present

The size and frequency of wildfires have increased recently, impacting ecosystems, communities, and human health. This research uses the heat-sensitive luminescence signals of quartz sand temper within archaeological pottery to record past wildfire conditions. Pottery sherds, which are fragments of archaeological pottery, from the forest floor in sites in New Mexico and Arizona were collected from different fire contexts (no fire exposure, historical fires, prescribed burns, and modern wildfires). These forests are primarily Ponderosa Pine with a grassy understory. The interior sand grains of each sherd sample were analyzed using optically stimulated luminescence, which dates when the mineral grains were …

Privacy-By-Design: Case Studies In Interactive Record Linkage Using A Hybrid Human-Computer System, Theodoros Giannouchos, Qinbo Li, Adam D'Souza, Elmer V Bernstam, Jeffrey R Curtis, Alva O Ferdinand, Cason Schmit

Faculty, Staff and Student Publications

Objective: High-quality patient matching from several sources without a common identifier (ID) requires interactive record linkage (RL) using a hybrid human-computer system. MiNDFIRL (MInimum Necessary Disclosure For Interactive Record Linkage) is a hybrid prototype software system that facilitates maximizing linkage accuracy while minimizing information disclosure. We present and evaluate MiNDFIRL using two real-world case studies.

Materials and methods: Two user studies were conducted linking 10,000 data pairs from EHR data and 18,240 unique patient IDs from patient generated data. After automated RL, manual review was conducted by three teams of four reviewers (12 total) using MiNDFIRL to resolve potential matches …

Constitutional Obiter Dicta On Male-Male Sex And Fundamental Rights In Singapore, Benjamin Joshua Ong

Research Collection Yong Pung How School Of Law

The Singapore Court of Appeal held a law prohibiting male–male sexual intercourse (s 377A of the Penal Code) unenforceable on non-rights-based grounds. The court's remarks about the rights to life and liberty (including whether sexual orientation is mutable), freedom of expression, and equality are obiter. But they are significant, since in Singapore, there are few constitutional rights cases and the courts focus on spelling out the limits to executive and legislative power without necessarily striking down exercises of such power on rights grounds. Indeed, the obiter dicta prompted the Legislature to repeal s 377A. Given the repeal, the obiter dicta …

Copyright In The Generative Ai Era: Reimagining Creativity And Fairness, Huijuan Peng, David Tan

Research Collection Yong Pung How School Of Law

This article examines the need for copyright reform in response to the transformative impact of generative artificial intelligence. It identifies key legal challenges, including the absence of clear criteria for authorship and the infringement risks associated with both inputs (training of large language models) and outputs (AI-generated content). The authors argue that two overarching themes—creativity and fairness—will drive the future development of copyright law. Through a comparative analysis of how three jurisdictions—the United States, China, and Singapore—have addressed these challenges, the article offers practical and forward-looking insights for navigating the complex copyright landscape of the generative AI era.

This article …

Imprisonment When An Offender Cannot Pay A Fine, Benjamin Joshua Ong

Research Collection Yong Pung How School Of Law

According to a common-law rule in place since the 1993 case of Low Meng Chay v Public Prosecutor [1993] 1 SLR(R) 46, if the court is minded to impose a fine but the offender will clearly be unable to pay a fine, the offender should be sentenced to imprisonment instead (as opposed to a fine coupled with a default imprisonment term). While one can understand why the courts may apply this practice, the practice obscures the crucial distinction between: (a) being sentenced to a fine, then imprisoned in default of payment (which, it is submitted, is the correct course of …

Copyright Ownership And Duration Of Ai-Authored Works, Cheng Lim Saw

Research Collection Yong Pung How School Of Law

On the assumption that Parliament has endorsed the notion of AI authorship and the prospect that copyright may well subsist in works created autonomously by the AI itself, this essay further explores allied issues surrounding the ownership and duration of copyright in AI-authored works.

A Cultural Identity Approach To The Generational Divide, Davelle Lee, Andree Hartanto

Research Collection School of Social Sciences

Some scholars have argued strongly against the idea that differences between generations are responsible for intergenerational conflict, calling for organisations and policymakers to do away with the notion of generations altogether. The current review argues that generations are an important social identity and makes the case for why generational identity should inform policy, despite inconsistent empirical evidence for generational differences. Drawing on cultural psychology and social identity theory, we find parallels between how racial and ethnic identities shape how people interpret and respond to racial diversity and so-called racial and ethnic “differences”, and how generational identity influences people's attitudes and …

Reliability And Validity Of A Self-Administrated Online Assessment Of Intrinsic Capacity: A Singapore Cohort Study, Paulin Tay Straughan, William Tov, Lay Khoon Lau, Li Ling Grace Cheong, Chong Sheng Micah Tan, William Tov, Yew Yoong Ding, Wee Shiong Lim

Research Collection School of Social Sciences

Objective: To ascertain the construct validity and reliability of a self-administered web-based assessment of intrinsic capacity (IC). Design: Cross-sectional data analysis of a prospective cohort study. Settings and Participants: We included data from 6,434 respondents (age, mean (SD): 65.33 (5.81) years; 52.4% women) of the Singapore Life Panel population study who participated in the online surveys in March 2022 and May 2022.MethodsIncremental nested factor structures of IC were modelled with confirmatory factor analysis (CFA) and their goodness-of-fit were assessed mainly with root mean square error of approximation (RMSEA), comparative fit index (CFI), Tucker-Lewis index (TLI), and standardized root mean square …

Does Social Media Undermine Trust? Institutional Trust In Civil Society And Governance Institutions, Christianna Sirindah Parr

Research Collection School of Social Sciences

What is the relationship between social media use and trust in civil society and governance institutions? In many parts of Asia, trust in government remains high despite limited political accountability and civil liberties. This study examines whether online political expression reshapes institutional trust in governance institutions and civil society organizations. The analysis considers the dual role of social media as a site for civic engagement and a channel for disaffection with formal authority. Using data from the Asian Barometer, the findings show that political expression on social media is associated with lower trust in governance institutions and higher trust in …

Attachment To Artificial Intelligence: Development Of The Ai Attachment Scale, Construct Validation, And The Psychological Mechanisms Of Human-Ai Attachment, K Tennakoon Appuhamillage Sandeeshwara Kasturiratna, Andree Hartanto

Research Collection School of Social Sciences

Artificial intelligence (AI) systems are increasingly integrated into daily life, not only as tools but also as social partners that people may turn to for interaction and support. This raises important questions about whether, how, and why individuals form attachment-like bonds with AI, and the psychological implications of such attachments. Across five studies involving 1259 unique participants from Singapore and the U.S., the current work developed and validated the 15-item AI Attachment Scale and investigated the dispositional and motivational factors associated with attachment to AI, as well as its emotional and social outcomes. The AI Attachment Scale displayed strong psychometric …

Factors Influencing The Provision Of Human Milk Feeding Support For Preterm Infants In Neonatal Intensive Care Units In China: A Qualitative Study Of Neonatal Nurses’ Perspectives, Wenjie Guo, Haiyan Zhang, Li Wang, Fang Huang, Dongmei Ma, Maggie Zgambo, Sanmei Chen, Yan Wu, Yanmei Bu, Yoko Shimpuku

Research outputs 2022 to 2026

Background: Human milk feeding is crucial for the survival and development of preterm infants, yet their human milk feeding rates at Neonatal Intensive Care Units (NICUs) discharge remain lower than those of healthy newborns. Effective support is essential for improving breast milk feeding outcomes, but remains challenging for NICU nurses. Therefore, this study aimed to examine factors that influence NICU nurses in providing human milk feeding support, including the challenges they face and their needs. Methods: This study employed a qualitative descriptive design. Using maximum variation and purposive sampling, 19 nurses in the NICU were recruited. Between August and September …

Longitudinal Associations Between Maternal And Child Screen Use At 1 Year Of Age And Child Behavior And Development At 3 Years Of Age, Stephanie Sim, Juliana Zabatiero, Natasha Bear, Amber Beynon, George Thomas, Ravisha Srinivasjois, Brad Jongeling, Desiree Silva, Leon Straker

Research outputs 2022 to 2026

Background: Young children are increasingly exposed to evolving screen technology. International guidelines recommend no screen use for children under the age of 2 years, due to the potential for detrimental effects on behaviour and development. However, evidence for these guidelines is limited by inadequate consideration of device-specific effects (TV and mobile phone/tablet computer), maternal screen use, confounders such as maternal mental health and importance of effect sizes. Our aim was to investigate longitudinal associations of device-specific maternal and child technology use and covariates (including maternal mental health) with behavioural and developmental outcomes, to guide adults on screen use behaviours by …

Midwife-Led Birth Debrief: A Concept Analysis, Kate Buchanan, Elliesha O'Reilly, Georgia Wilcox, Sara Bayes, Lauren Kearney, Linda Sweet, Hazel Keedle

Research outputs 2022 to 2026

Background: Psychological birth trauma (PBT) affects approximately 19 % of postnatal women, making its prevention a global priority. Midwives are responsible for providing psychosocial care during the postnatal period to foster the mother-infant relationship, provide education and screening and support positive transitions to parenting. However, the specific attributes of a birth debrief and the role of the midwife in a supporting a woman to review their birth experience is less well documented in regulatory frameworks or scientific literature. This has created significant ambiguity in both clinical practice among health professionals and in research contexts. The lack of a clear understanding …

Periodizing Exercise Medicine Prescription For Patients With Cancer: A Narrative Opinion, Francesco Bettariga, Robert U. Newton, Chris Bishop, Luca Maestroni, Anita Borsati, Alice Avancini, Sara Pilotto, Dennis R. Taaffe, Daniel A. Galvão, G. Gregory Haff

Research outputs 2022 to 2026

Exercise has emerged as an effective therapeutic strategy in cancer management. Long-term supervised exercise programs, including resistance training and aerobic training, can improve body composition and physical fitness, modulate circulating factors (e.g., hormones, cytokines), enhance treatment tolerance, and reduce side effects, potentially influencing cancer progression and reducing mortality risk. Despite advancements in exercise oncology, opportunities remain to refine exercise prescription through the integration of advanced methodologies such as periodization and autoregulatory programming strategies. Periodization, a systematic approach to organizing training over time, has demonstrated benefits in general fitness and clinical populations but is underexplored in cancer care. Emerging evidence suggests …

Relationships Of Upper Respiratory Tract Infections And Holistic Diets And Lifestyles In Northeast China, Hongmei Wang, Khui Hung Lee, Shaoxiao Qin, Kan Yu, Shaoying Hou, Kaihong Tang, Jiabao Liu, Yingyu Jin, Zhuo Shang, Deyu Dai

Research outputs 2022 to 2026

Background: Upper respiratory tract infections (URTIs) are prevalent public health issues worldwide. Their prevention is challenging, and they pose a significant economic burden due to their susceptibility to secondary infections and lack of effective treatments. This study investigates the relationship between URTIs and the holistic diets and lifestyles of residents in Northeast China. Methods: A cross-sectional study was conducted using data from 4058 participants aged 12 to 70 who participated in the Internet-based dietary questionnaire for Chinese (IDQC), collected between 2012 and 2019. Statistical analyses were performed with SPSS 20.0 software, employing chi-square tests for categorical data and Kruskal-Wallis tests …

Teaching Computer-Based Writing: Primary Teachers’ Preparation, Self-Efficacy, And Instructional Practices, Anabela Malpique, Debora Valcan, Deborah Pino-Pasternak, Susan Ledger

Research outputs 2022 to 2026

In the digital age, skilful computer-based writing is essential for school aged children since it empowers them to communicate, acquire knowledge, critically engage with information, and produce text-based original thoughts. However, there is a lack of studies examining teachers’ preparation and self-efficacy for supporting students in developing computer-based writing skills and instructional practices implemented in primary classrooms. In the current study, 340 primary teachers (Grades 1–6) from across Australian states completed a survey about the computer-based writing instruction provided in their classrooms. While results showed that teachers found it was important to teach computer-based writing skills, most respondents reported allocating …

The Use Of Force Plate Technology To Measure Force Production Characteristics In Military Personnel: A Scoping Review Of Methodological Reporting Practices, Peter Ladlow, Kieran M. Lunt, Paul Comfort, Oliver O’Sullivan, Francisco J. Robles-Palazón, Nicholas J. Ripley, John J. Mcmahon, Natalie Masters, Robyn P. Cassidy, Marina De Vecchis, Vanessa Bell, Alexander N. Bennett, Russell J. Coppack

Research outputs 2022 to 2026

Background: Force plates have become one of the most frequently used assessment tools in the field of strength and conditioning research and applied practice. Their use for measuring force production characteristics among military personnel is growing. The aim of this scoping review is to: (1) Describe the current evidence base underpinning the use of force plates to assess maximal and rapid lower-limb force production in military in three priority areas; occupational task performance, injury risk profiling, and rehabilitation, (2) Identify potential trends and/or differences by participants’ sex, job role, and/or level of performance in tests, methodologies, and metrics selected, and …

Therapeutic Potential And Enhanced Bioactivity Of Ficus Carica (Fig) Fruit: Exploring Bioactive Compounds And Nano-Additive Synergies, Mst Sumya Yeasmin, Shamima Abdul Rahman, Waheedah Abdul Hakeem, Tarek Abedin, Mohammad Nur-E-Alam

Research outputs 2022 to 2026

The present investigation deals with the phytochemical, anticancer, antioxidant, anti-inflammatory, antidiabetic, and Anti-constipation activities of Ficus carica (FC) fruit. The phytochemical analysis of FC fruit has revealed a rich array of bioactive compounds, highlighting the fruit's complex and diverse natural chemistry together with some secondary metabolites that contribute to its high antioxidant activity which was evident from 1-Diphenyl-2-picrylhydrazyl (DPPH), 2,2′-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and Ferric reducing power (FRAP) assays. Fruit extracts of FC demonstrated anticancer activity against MCF-7 breast cancer, U2OS osteosarcoma, HepG2 liver cancer, and Huh7it liver cancer cell lines. The anti-inflammatory activity of FC fruit is attributed to steroids …

Interhemispheric Inhibition Modifies Reaction Time Of The Index Finger, Liam C. Tapsell, Christopher Latella, Anthony J. Blazevich, Janet L. Taylor

Research outputs 2022 to 2026

Interhemispheric inhibition (IHI) acts between hemispheres to decrease motor cortical excitability. IHI changes during movement preparation, but it is unknown whether altering IHI, independent of other factors, alters movement initiation. For the index finger abductor muscle (first dorsal interosseous; FDI), IHI is weaker during contralateral index abduction than adduction. Thus, this study aimed to modulate IHI through contralateral contraction and measure resultant changes in reaction time. Fifteen healthy participants (age 19–39 years) completed a reaction-time task requiring brief left index finger abduction. Prior to reactions, participants started either a sustained isometric abduction or adduction contraction of the right index finger. …

A Configurational Approach To Strategic Entrepreneurship: Unlocking Customer Success In New Ventures In Emerging Economies, Sayuri Wijekoon, Mahdi Vesal, Aron O'Cass

Research outputs 2022 to 2026

New ventures (NVs) in emerging economies often face significant challenges in cultivating quality customer relationships and achieving customer satisfaction. This study applies the strategic entrepreneurship framework and configurational theory to investigate how combinations of strategic behaviors, decision-making logics, resource allocation mechanisms, and leader sociocognitive characteristics influence customer-focused performance. Utilizing multi-informant data from 135 NVs (entrepreneurs and marketing managers) in Sri Lanka, our analysis reveals that NVs employing effectual decision-making and bricolage resource allocation achieve stronger alignment between entrepreneurial and market orientations, resulting in enhanced customer satisfaction and stronger relationships. Additionally, the study identifies entrepreneurs’ long-term orientation and managers’ perfectionism as …