Digital Commons Network^™

Direct Measurement Of Mavacamten And Deoxyatp Perturbation Of The Srx/Drx Ratio In Porcine Cardiac Myofibrils Using A Simple, Accessible And Multiplexed Approach, Matvey Pilagov, Ateeqa Naim, Kenneth S. Campbell, Thomas Kampourakis, Michael A. Geeves, Neil M. Kad

Physiology Faculty Publications

Cardiac muscle adapts to varying physiological demands by modulating the number of active myosin II motors available for contraction. These motors are organized into thick filaments in the sarcomere and generate force through an ATP-dependent interaction with thin filaments that contain actin. To conserve energy, when demand is low myosin can occupy the super-relaxed (SRX) state, which acts as a reserve. Here, we build upon the earlier studies to quantify the size of this cardiac reserve using fluorescence imaging of Cy3-ATP directly in myofibrils. This approach employs a pulse-chase method and exploits the high permeability of isolated myofibrils to monitor …

Inhibition Of Astrocyte Signaling Leads To Sex-Specific Changes In Microglia Phenotypes In A Diet-Based Model Of Cerebral Small Vessel Disease, Jenna L. Gollihue, Khine Zin Aung, Colin B. Rogers, Leopoldine B. Galopin, Nicholas A. Wright, Pradoldej Sompol, Erica M. Weekman, Yuriko Katsumata, Josh M. Morganti, Christopher M. Norris

Physiology Faculty Publications

Hyperhomocysteinemia (HHcy)-inducing diets recapitulate cerebral small vessel disease phenotypes in mice including cerebrovascular pathology/dysfunction, neuroinflammation, synaptic deficits, and cognitive decline. We recently showed that astrocyte signaling through calcineurin(CN)/nuclear factor of activated T cells (NFATs) plays a causative role in these phenotypes. Here, we assessed the impact of astrocytic signaling on microglia, which set the inflammatory tone in brain. Seven-to-eight-week-old male and female C57BL/6 J mice received intrahippocampal injections of adeno-associated virus (AAV) expressing EGFP (AAV2/5-Gfa2-EGFP) or AAV expressing the NFAT inhibitor VIVIT (i.e., AAV2/5-Gfa2-VIVIT-EGFP). Mice were then fed with control chow (CT) or B-vitamin-deficient chow for 12 weeks to induce …

Micro/Nanomechanical Properties Of Top-Seeded Melt Grown Ybco Single Crystals Determined Using Depth Sensing Indentation, Ugur Kolemen, Cafer Mert Yesilkanat, Fikret Yilmaz, Fatih Dogan, Orhan Uzun

Materials Science and Engineering Faculty Research & Creative Works

Mechanical properties of the bulk YBa2Cu3O7-x (YBCO) single crystal superconductor, prepared by using the Top Seeded Melt Growth (TSMG) method, were determined. Property measurements were conducted by the nanoindentation method under various loads and the micro indentation method at different temperatures. Hardness (H) and reduced elastic modulus (Er) values were calculated by using the Oliver–Pharr method. According to hf/h max values found from load- displacement curves, there is a sink in behavior around outer rim of the indents that was confirmed by atomic force microscopy (AFM) analysis. Nanoindentation analyses conducted on upper section, middle section and subsection revealed that all …

Best Practices: Lean Thinking For Corn And Soybean Farmers, Tomas Gutierrez, Henry Quesada

Purdue Extension Numbered Publications

This article presents a practical introduction to lean thinking for corn and soybean farmers. Lean is a proven management approach that helps reduce waste, organize workspaces and improve the use of time, tools, and materials. Although it began in manufacturing, lean has been successfully adapted to agriculture through simple, low-cost tools that focus on improving everyday tasks.

The guide explains six key lean tools — 5S, Kanban, Visual Controls, TPM, Standardization, and Kaizen — with real farm examples and step-by-step recommendations. It also offers advice on how to get started, involve workers and measure improvements using basic indicators.

Lean thinking …

Digital Literacy And Family Engagement For Student Success, Genesis B. Mendoza

Capstone Projects and Master's Theses

The North Monterey County Unified School District (NMCUSD) in Castroville, California, serves a student population in which 87.5% are identified as low-income and nearly half are designated as English Language Learners. Families face significant barriers to accessing educational and community resources, barriers worsened by limited digital literacy and technology access. The NMCUSD Castro Plaza Family Resource Center serves as a vital hub supporting families in the predominantly rural and socioeconomically disadvantaged region. This project aimed to strengthen family engagement and digital inclusion through hands-on workshops. Workshop topics included online student registration and data verification, training on essential district digital tools …

An Analytical Assessment Of Sentiment Analysis Trends And Methods Through Systematic Review And Topic Modeling, Chelsey Hill, Fatima Irshaidat, Marina Johnson, Jorge Fresneda

Department of Information Management and Business Analytics Faculty Scholarship and Creative Works

Sentiment Analysis (SA) applies Artificial Intelligence (AI) and Machine Learning (ML) techniques to identify and interpret opinions, emotions, and sentiment polarity in text data. This study presents a systematic literature review of SA research published between 2012 and 2024 using a dataset of 14,482 journal articles indexed in Scopus. The primary objective of this research is to provide a data-driven overview of the evolution of SA research, offering insights into methodological evolutions, emerging application areas, and the growing influence of AI in the field. The research findings reveal a multidisciplinary growth of SA research, with increasing contributions from Health Sciences …

The Wisdom Of The Lexicon Crowds: Leveraging On Decades Of Lexicon-Based Sentiment Analysis For Improved Results, Chelsey H. Hill, Jorge E. Fresneda, Murugan Anandarajan

Department of Information Management and Business Analytics Faculty Scholarship and Creative Works

The “wisdom of the crowd” (WoC) refers to the notion that collective human knowledge is capable of outperforming even individual expert knowledge. This study investigates the application of this phenomenon to lexicon-based sentiment analysis of text data. Lexicons are frequently used to classify the sentiment of text data, particularly in the absence of sentiment class label information. We propose leveraging some of the most popular, publicly-available lexicons created in the last half century to improve sentiment analysis performance. Specifically, this research argues that the collective information provided by the thirteen lexicons included in the crowd constitutes a WoC situation that …

Injury Prevention And Care Training Website, Samantha E. Myers

Theses/Capstones/Creative Projects

Injury Prevention and Care is a University of Nebraska Omaha (UNO) resource within Campus Recreation and Wellness. It serves a variety of students, staff, , and other membership holders with a variety of resources and treatments in caring for injuries and in seeking to prevent new or worsening of injuries. In facilitating the health and growth of this department and their staff, updating the current training resources, and making them more accessible was necessary. Moving forward, discussions of the importance of accessibility and providing various resources, both in IPC and across the UNO campus, were pivotal in the formation and …

Pathways To Aggression: Understanding Peer Victimization In Adolescence, Makenzie H. Clarken

Theses/Capstones/Creative Projects

Insight into aggression among early adolescents is important to understanding its predictors and consequences. In adolescence, aggression is typically related to underlying issues. Addressing this is important, as unmanageable aggression progressing past early adolescence can result in involvement in the criminal justice system. Studies show that peer victimization is associated with increased levels of aggression. Aggressive adolescents may attract victimization from their peers, or those who are victimized may respond with aggression. The current study followed a sample of 182 fifth and sixth graders over the course of the school year. Constructs such as aggression, peer victimization, and social withdrawal …

The Participation Gap: Inequitable Speaking Times In Majority Women Classes, Cat Koenig

Theses/Capstones/Creative Projects

This study examined the participation of men and women in majority women classes. The participation of men and women was recorded in three majority women communication classes from August through October. It was found that even in majority women classes and majors, men still participate and interrupt disproportionately more. This result raises important questions about the continued presence of the chilly climate in the university setting- even in areas traditionally dominated by women. Equitable participation in the university classroom still has a ways to go, but professors may well be the answer to this problem (Farago & Flora, 2022). Prompting …

Empowerment Or Imprisonment? The Line Between Sex Work And Sex Trafficking: A Comparison Of Law Enforcement And Academic Perspectives, Jocelyn Belcastro

Theses/Capstones/Creative Projects

This research explores the line between consensual sex work and sex trafficking to gain a better understanding of the prevalence and pathways through which sex work may transition into sex trafficking. Semi-structured interviews were conducted with law enforcement professionals that work closely with survivors of sex trafficking to examine the pathways from consent to coercion. An interview with a former sex worker, now college professor, was also conducted to examine the lived experience and academic perspective. Both the law enforcement and academic perspectives were analyzed and compared to one another to form a nuanced understanding of the complex issue of …

Comparative Analysis Of The Effects Of Peppermint Oil On Colorectal Cancer Cells And Human Fibroblasts, Allen W. Mccumbers

Theses/Capstones/Creative Projects

This study contrasted the effects of Peppermint Oil on two cell lines, HT29s (colorectal adenocarcinoma cells) and HFFs (Human Foreskin Fibroblasts). Cytotoxic as well as genomic effects were compared between the cell lines. Trypan Blue, Alamar Blue, and qPCR assays were used to study these effects. Both cell lines were treated with a range of Peppermint Oil concentrations, and it was determined that there is a dose-dependent factor associated with cytotoxicity. To confirm results, Alamar and Trypan Blue assays were repeated at 300 and 500 cells/mL respectively. Effects were confirmed, and results were averaged and plotted. Alamar Blue revealed that …

Holistically Analyzing The Initial Athlete-Provider Interaction During Sports Injury Diagnosis, Tyler Baldwin

Theses/Capstones/Creative Projects

Recovering from injury is crucial for an athlete’s health-related quality of life and mental health. A potentially significant moment that could influence an athlete’s mindset towards recovery is the interaction between the provider and athlete during initial diagnosis. To analyze this moment from both perspectives, this study performs a thematic analysis of five semi-structured provider interviews and ten athlete interviews. In this study, all five providers exemplified an understanding of this moment’s significance, expressing awareness of their potential impact on the athlete’s mindset, and emphasizing mutual understanding to ensure streamlined recovery. Meanwhile, all ten of the athletes expressed self-awareness regarding …

Cal Poly Semester Conversion Time Capsule, Maximus La Via, Matthieu Gol, Viki Sarmasi, Tuyetthuc Nguyen

Mechanical Engineering

As Cal Poly transitions from the quarter system to the semester system, aligning itself with the other California universities, the idea has been proposed to commemorate this moment in the history of the university with a time capsule. The time capsule will be on display on the first floor of the library for a few years and later moved into the library’s archive room for permanent storage. 50 years after the completion of the semester conversion project, the time capsule will be opened. This project aims to create a secure and aesthetic device capable of storing and protecting memorabilia from …

Intentional Improvement Through 3d Environment Art, Samuel T. Pinnex

Master of Fine Arts in Digital Media Culminating Experience

The idea of self-growth can be exciting—the thought of where one might be in the near or distant future is exhilarating. As an artist, this is even more apparent. On the other side of that coin, the realization that it is all up to you can oftentimes be overwhelming. We all want to improve, and we want our work to improve with us as a showcase of that improvement. Over the past two years, I’ve learned how valuable it is to adopt a “growth mindset”. Once I became comfortable with this idea, the responsibility for my own self-growth no longer …

“For Whom The Bell Tolls”?* Is The Corporate Transparency Act Dead, And If Not, What Is Its Impact On Corporate Governance?, Kellen Ware

UC Law Business Journal

The Corporate Transparency Act (“CTA” or “the Act”) was enacted by Congress in 2021 to combat illicit financial activity through mandated beneficial ownership disclosure. While the current administration has opted not to enforce the CTA’s reporting requirements on domestic entities, the law remains in effect, and its future is uncertain amid ongoing constitutional litigation.

This Note argues that the CTA should be repealed, and state legislatures should refrain from mirroring the Act. The CTA creates undue burdens that threaten effective and efficient corporate governance in small businesses and many non-profits. This Note traces the contentious history of the CTA and …

Public Engagement In Small-Town Planning: A Case Study Of The Wellsville Trails And Active Transportation Plan, Tayli R. Hillyard

All Graduate Reports and Creative Projects, Fall 2023 to Present

This thesis presents a qualitative case study of public engagement in the Wellsville Trails and Active Transportation Plan, developed in Wellsville, Utah—a small municipality with limited staff and resources. Drawing from planning literature on effective community participation, the study evaluates outreach strategies based on their reach, feasibility, and replicability. Outreach strategies in the plan’s development included surveys, stakeholder meetings, a public open house, digital tools, and informal conversations. While early outreach efforts, such as the interest survey and personal invitations, generated meaningful input, the process fell short in sustaining engagement, reaching underrepresented groups, and maintaining consistent communication. The analysis highlights …

Identifying Barriers For Community Pharmacies As Vaccines For Children (Vfc) Providers In Rural Alabama: Opportunities For Solutions, Myra Bajwa

Honors Theses

Significant Human papillomavirus (HPV) vaccination disparities exist between rural and urban areas in the US. A primary contributor is low access to preventive care in rural areas. Among the most promising strategies to overcome this is increasing access through offering HPV vaccination in non-traditional, convenient health settings such as pharmacies. In rural areas, community pharmacies are trusted, convenient pillars of the community. In Alabama, community pharmacies are eligible for enrollment in the Vaccines for Children (VFC) Program, a federally-funded program that provides free vaccines to children and adolescents under 18 years old who are uninsured, underinsured, American Indian, or Alaska …

Exploring Internship’S Role In Non-Virtual Social Capital Development: A Gen Z Student Perspective, Christina M. Galli

Dissertations

Gen Z students often complete internships as they prepare to enter the workforce (Maloni et al., 2019; Shtembari & Elgün, 2023). However, because the population relies heavily on digital technology to develop social relationships, Gen Z students may not have the social skills to develop non-virtual social capital (Fernandez et al., 2023; Henry & Shannon, 2023; Osorio & Madero, 2024). Existing research focuses on Gen Z individuals as students (Maloni et al., 2019; Pichler et al., 2021; Shtembari & Elgün, 2023). However, existing literature lacks specifications about Gen Z students’ strategies for gaining non-virtual social capital through internship experiences. This …

Institutional Sustainability In Ai Governance: Comparing Paths In The Eu, Japan, And Taiwan, Kuan-Wei Chen

Yearbook of Antitrust and Regulatory Studies

This article explores the concept of institutional sustainability in AI governance by comparing the approaches in the European Union, Japan, and Taiwan. It begins by arguing that the relationship between AI and sustainability extends beyond environmental concerns, encompassing the sustainability of governance institutions themselves. The article posits that institutional sustainability, referring to the capacity of governance frameworks to remain effective over time, is essential in the context of rapidly evolving and future-oriented AI governance. The analysis proceeds by examining the EU’s strategy of normative anchoring through legal codification, Japan’s agile governance model based on collaboration and coordination, and Taiwan’s digital …

Marsanywhere: Dataset And Cross-View Diffusion Model For Satellite-To-Ground View Synthesis With Mars Data, Benjamin T. Hinchliff

Master's Theses

Satellite-to-ground view synthesis aims to create a realistic ground view image from a corresponding satellite view image. This is a well-studied problem for street level imagery, with good results being achieved by using modern image synthesis techniques such as diffusion models. However, despite the public availability of satellite and ground level imagery on Mars, these techniques have yet to be applied to the domain due to difficulties in collating and processing the data into a usable form. We address this deficiency by creating a dataset consisting of ground view panorama imagery from the Perseverance rover, along with associated satellite view …

The Moderating Effect Of Income Inequality On The Income–Emissions Relationship In G20 Countries, Zahra Rizky Fadilah, Budiasih Budiasih

Economics and Finance in Indonesia

This study analyzes the moderating effect of income inequality on the income–emissions relationship in the environmental Kuznets curve (EKC) framework. Findings indicate that the relationship is inverted U-shaped in middle-income G20 countries, but monotonically increasing in high-income G20 countries. Interestingly, income inequality moderates this relationship only in the latter group. These findings suggest that middle-income G20 countries should focus on raising income per capita to mitigate environmental degradation, while their high-income counterparts need to prioritize reducing income inequality to effectively decouple income from emissions.

Lived Experiences Of Chemotherapy-Induced Nausea And Vomiting Among Patients Diagnosed With Cancer At Machakos Level Five Hospital, Nancy Njeri Kamau

MSc in Advanced Practice Nursing

Background: Chemotherapy-induced nausea and vomiting (CINV) remains one of the most prevalent and distressing adverse effects of cancer treatment, affecting a substantial proportion of patients and significantly compromising their physical functioning, nutritional status, treatment adherence, and overall quality of life. However, there is a paucity of localized evidence on the magnitude and functional burden of CINV among patients diagnosed with cancer receiving chemotherapy at county referral hospitals, such as Machakos Level 5 Hospital, hence the current study.

Aim of the study: The study aimed at exploring the lived experiences of chemotherapy induced nausea and vomiting among patients diagnosed with …

From The Bench To The Feed: Conflict Between Public Official Accounts And The First Amendment, Betty Yu

Washington Law Review

Imagine one day waking up, opening Facebook, and discovering that the official White House account blocked you because you left a comment expressing a viewpoint. In this case, your First Amendment right to free speech would most likely be violated. However, what happens if your local official blocks you or deletes your comments? Are your First Amendment rights violated? Well, it depends.

Historically, public officials have used public forums such as town halls to meet with citizens and answer questions. However, as social media platforms like X and Facebook have become increasingly crucial tools for communication, the distinction between personal …

The Guardian The Month Of December 2025, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the Month of December 2025. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

Colophon

The Prairie Light Review

No abstract provided.

Combating Antimicrobial Resistance In Asia: A Comprehensive Review Of Strategic Action Plans, Policies, And The Role Of The Who, Saud Almawash

Saudi Medical Journal

ABSTRACT Over the past 70 years, antimicrobial resistance (AMR) has emerged as a critical public health concern in Asia. Regional challenges such as dense population, scarce resources, and diverse healthcare systems further complicate the containment efforts. To address this, Asian countries have adopted several strategies and policies. A comprehensive review of published literature was conducted to identify key policies and interventions. Findings revealed diverse approaches to AMR containment, including surveillance and monitoring systems, antibiotic stewardship programs, infection control measures, vaccination strategies, and public health awareness campaigns. However, implementation of these strategies is hindered by resource, political, and regulatory barriers. The …

Unlocking Hidden Health Risks: Exploring Community-Based Screening For Kidney Disease, Rehab B. Albakr, Fadel Alrowie, Ibrahim A. Sandokji, Omar A. Alshammari, Hadeel A. Mitwalli, Hamood Alsudais, Abdulaziz B. Albacker, Mohamad-Hani Temsah, Ahmed H. Mitwalli, Khalid A. Alhasan

Saudi Medical Journal

ABSTRACT Objectives: To conduct a community-wide screening of the Saudi population for chronic kidney disease risk factors. Methods: This study utilized a non-selective, exploratory point-of-care screening approach involving 215 participants in Riyadh, Saudi Arabia, during a kidney disease awareness campaign for World Kidney Day in March 2022. Participants were randomly selected, and their estimated glomerular filtration rates (eGFRs) were measured to assess kidney function. Results: The findings revealed that 4% of participants had eGFRs less than 60 mL/min/1.73 m², 34% had eGFRs between 60 and 90 mL/min/1.73 m², and the rest had eGFRs over 90 mL/min/1.73 m². Key risk factors …

Why Doody's New Health Humanities List Is A Vital Catalyst, Sandra Y. Desjardins

Library Staff Publications

No abstract provided.

A Feasibility Study Of Sexual Organ-Dose Sparing Volumetric Modulated Arc Therapy In Female Low Rectal Cancer Patients Treated With Three-Dimensional Conformal Radiation Therapy, Margaret Downes, Victoria Olsen, Andre Williams, Rendi Sheu, Maria Thor, Lucy Greenwald, Vishruta Dumane, Kristin Hsieh, Ayesha Ali, Orly Morgan, Michael Buckstein, Deborah Marshall

Department of Radiation Oncology Faculty Papers

BACKGROUND: Sexual dysfunction is a significant toxicity of pelvic radiation therapy (RT) for female rectal cancer patients and may be more common with intensity-modulated techniques compared to three-dimensional conformal radiation therapy (3D-CRT). However, limited research has evaluated dose sparing of female sexual organs at risk (OARs), particularly erectile tissues that are critical for sexual function.

PURPOSE: This feasibility study aimed to demonstrate the practicality of contouring and sparing female sexual OARs in rectal cancer RT by generating sexual organ-sparing volumetric modulated arc therapy (SO-VMAT) plans from a small 3D-CRT cohort and comparing dose distributions to guide future planning.

METHODS: Nine …