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Articles 58591 - 58620 of 1740508
Full-Text Articles in Entire DC Network
Identity Salience Of Organizational Culture: The Intersection Of Racial And Occupational Identities In High-Risk Professions, Sarah Espinosa
Identity Salience Of Organizational Culture: The Intersection Of Racial And Occupational Identities In High-Risk Professions, Sarah Espinosa
School of Public Service Theses & Dissertations
Despite decades of effort, issues of race and color in organizations remain unresolved. Representative Bureaucracy (RB) has been a necessary but insufficient response to these challenges. While RB promotes diversity and inclusion, it struggles to address deeper issues of equity and justice, which are seen in the persistence of police brutality, even with increased representation of officers of color. This dissertation will propose a new theoretical approach to address the shortcomings of RB, a framework for the Identity Salience of Organizational Culture (ISOC). The ISOC framework seeks to build beyond RB to explain how the culture of high-risk professions with …
Building Resilience: Pastoral Preparation And In-Ministry Support, David Sedlacek
Building Resilience: Pastoral Preparation And In-Ministry Support, David Sedlacek
Faculty Publications
No abstract provided.
Assessing U.S. Fatal & Nonfatal Injury Trends By Worker Age, Alexander Mcdaniel
Assessing U.S. Fatal & Nonfatal Injury Trends By Worker Age, Alexander Mcdaniel
All-Inclusive List of Electronic Theses and Dissertations
Occupational injuries and fatalities in the United States have declined over time; however, meaningful differences by worker age remain a concern for employers and safety professionals. Younger workers often experience higher non-fatal injury rates due to limited experience and developing hazard-recognition skills, while older workers face increased risk of severe and fatal outcomes related to age-associated physical changes. The purpose of this study was to analyze long-term injury and fatality trends by age group and determine whether differences exist over time. National injury data from the Census of Fatal Occupational Injuries (1992–2023) and the Survey of Occupational Injuries and Illnesses …
A Study Of Configuration Management Database (Cmdb) Adoption In It Service Management (Itsm) Implementations Within Nj Community Colleges, Fredrick Dande
A Study Of Configuration Management Database (Cmdb) Adoption In It Service Management (Itsm) Implementations Within Nj Community Colleges, Fredrick Dande
All-Inclusive List of Electronic Theses and Dissertations
This study examines the adoption of Configuration Management Databases (CMDBs) in IT Service Management (ITSM) implementations within New Jersey (NJ) community colleges. Despite the well-documented benefits of CMDBs—such as faster issue resolution, improved compliance, and greater visibility across IT infrastructures—implementation success rates remain low. As technology continues to enhance production capabilities and expand access to information, the need for centralized configuration visibility has become critical. A CMDB provides a single system of record for IT assets and services, helping organizations manage outages, assess changes, maintain compliance, and improve asset tracking. This research used an online survey to collect data from …
Quantization For The Mixtures Of Overlap Probability Distributions, Asha Barua, Angelina Chavera, Ivan Djordjevic, Valerie Manzano, Sergio Soto Quintero, Mrinal Kanti Roychowdhury, Hilda Tejeda
Quantization For The Mixtures Of Overlap Probability Distributions, Asha Barua, Angelina Chavera, Ivan Djordjevic, Valerie Manzano, Sergio Soto Quintero, Mrinal Kanti Roychowdhury, Hilda Tejeda
School of Mathematical & Statistical Sciences Faculty Publications
Optimal quantization for mixed distributions has emerged as a compelling area of study. In this work, we have focused on a mixed distribution formed from two uniform distributions with partially overlapping supports. For this class of distributions, we have examined the structure of optimal sets of n-means and the corresponding nth quantization errors for all positive integers n. Initially, we explicitly determined the optimal sets and quantization errors for 1 < = n < = 6. Subsequently, we established several key lemmas and propositions and proposed an algorithm that facilitates the computation of optimal n-means and quantization errors for all n >= 5. Numerical results are also presented to illustrate the application of the algorithm in deriving these quantities. The findings of this study offer valuable insight and serve as a …
Variants Of Conway Checkers And K-Nacci Jumping, Glenn Bruda, Joseph Cooper, Kareem Jaber, Raul Marquez, Steven J. Miller
Variants Of Conway Checkers And K-Nacci Jumping, Glenn Bruda, Joseph Cooper, Kareem Jaber, Raul Marquez, Steven J. Miller
School of Mathematical & Statistical Sciences Faculty Publications
Conway Checkers is a game played with a checker placed in each square of the lower half of an infinite checkerboard. Pieces move by jumping over an adjacent checker, removing the checker jumped over. Conway showed that it is not possible to reach row 5 in finitely many moves by weighting each cell in the board by powers of the golden ratio such that no move increases the total weight.
Other authors have considered the game played on many different boards, including generalizing the standard game to higher dimensions. We work on a board of arbitrary dimension, where we allow …
Is Noise Exposure Associated With Impaired Extended High Frequency Hearing Despite A Normal Audiogram? A Systematic Review And Meta-Analysis, Sajana Aryal, Monica Trevino, Hansapani Rodrigo, Srikanta K. Mishra
Is Noise Exposure Associated With Impaired Extended High Frequency Hearing Despite A Normal Audiogram? A Systematic Review And Meta-Analysis, Sajana Aryal, Monica Trevino, Hansapani Rodrigo, Srikanta K. Mishra
School of Mathematical & Statistical Sciences Faculty Publications
Understanding the initial signature of noise-induced auditory damage remains a significant priority. Animal models suggest the cochlear base is particularly vulnerable to noise, raising the possibility that early-stage noise exposure could be linked to basal cochlear dysfunction, even when thresholds at 0.25-8 kHz are normal. To investigate this in humans, we conducted a meta-analysis following a systematic review, examining the association between noise exposure and hearing in frequencies from 9 to 20 kHz as a marker for basal cochlear dysfunction. Systematic review and meta-analysis followed PRISMA guidelines and the PICOS framework. Studies on noise exposure and hearing in the 9 …
Social Well-Being Moderates Behavioral Therapy Response For Generalized Anxiety Disorder., Jacob D. Armstrong, Nicole R. Baughman, Ricardo A. Wilhelm, Dalia El-Shafie, Hannah Berg, Hung-Wen Yeh, Elisabeth Akeman, Christopher Martell, Kate B. Wolitzky-Taylor, Michelle G. Craske, Martin P. Paulus, Robin Aupperle
Social Well-Being Moderates Behavioral Therapy Response For Generalized Anxiety Disorder., Jacob D. Armstrong, Nicole R. Baughman, Ricardo A. Wilhelm, Dalia El-Shafie, Hannah Berg, Hung-Wen Yeh, Elisabeth Akeman, Christopher Martell, Kate B. Wolitzky-Taylor, Michelle G. Craske, Martin P. Paulus, Robin Aupperle
Manuscripts, Articles, Book Chapters and Other Papers
INTRODUCTION: Identifying moderators of treatment outcome for depression and anxiety offers promise for personalizing treatment or providing novel intervention targets. Indices of social well-being have emerged as candidate moderators due to their robust impact on mental health and quality of life. Here, we examine whether measures of social support, isolation, and loneliness moderate outcomes to behavioral activation (BA) and exposure-based therapy (EXP) for individuals with GAD.
METHODS: This secondary analysis of a randomized clinical trial included 69 participants (31 EXP, 38 BA). Participants completed the GAD-7, along with NIH PROMIS (Depression; Social Isolation; and Emotional, Instrumental, and Informational Support) and …
Trends In Hospital Resource Use For Children With Complex Chronic Conditions., Nathaniel D. Bayer, Matthew Hall, Maria Osipovich, John M. Morrison, Christian D. Pulcini, Jana C. Leary, Joanna E. Thomson, Tamara D. Simon, Dennis Z. Kuo, Jeffrey D. Colvin, Eyal Cohen, Jay G. Berry
Trends In Hospital Resource Use For Children With Complex Chronic Conditions., Nathaniel D. Bayer, Matthew Hall, Maria Osipovich, John M. Morrison, Christian D. Pulcini, Jana C. Leary, Joanna E. Thomson, Tamara D. Simon, Dennis Z. Kuo, Jeffrey D. Colvin, Eyal Cohen, Jay G. Berry
Manuscripts, Articles, Book Chapters and Other Papers
IMPORTANCE: Despite a small prevalence, children with complex chronic conditions (CCCs) use substantial inpatient resources.
OBJECTIVE: To assess national trends in hospital discharges, bed days, and hospital charges for children with and without CCCs in the US from 2000 to 2022.
DESIGN, SETTING, AND PARTICIPANTS: This retrospective, repeated cross-sectional study used hospital discharge data from the Kids' Inpatient Database (KID) from the years 2000, 2003, 2006, 2009, 2012, 2016, 2019, and 2022 for US children aged 0 to 18 years, excluding uncomplicated newborn discharges.
EXPOSURE: Presence of 0, 1, 2, or 3 or more CCCs.
MAIN OUTCOMES AND MEASURES: Trends …
Elevated Serum Bile Acids Predict Poor Liver Outcomes In Children With Alagille Syndrome: Results From The Gala Study Group., Carla Fiorella Murillo Perez, Shannon M. Vandriel, Emmanuel M. Gonzales, Jian-She Wang, Li-Ting Li, Huiyu She, Irena Jankowska, Piotr Czubkowski, Dorota Gliwicz-Miedzińska, Emmanuel Jacquemin, Jérôme Bouligand, Lorenzo D'Antiga, Emanuele Nicastro, Björn Fischler, Henrik Arnell, Susan M. Siew, Michael Stormon, Kathleen M. Loomes, David A. Piccoli, Elizabeth B. Rand, James E. Squires, Saul J. Karpen, Rene Romero, Mureo Kasahara, Zerrin Önal, Étienne Sokal, Tanguy Demaret, Sabina Wiecek, Florence Lacaille, Dominique Debray, Winita Hardikar, Sahana Shankar, Pamela L. Valentino, Shikha S. Sundaram, Noelle H. Ebel, Jeffrey A. Feinstein, Orith Waisbourd-Zinman, Henry C. Lin, Nathalie Rock, Henkjan J. Verkade, M Kyle Jensen, Catalina Jaramillo, Kyung Mo Kim, Seak Hee Oh, Jernej Brecemiclj, Seema Alam, Giuseppe Indolfi, Niviann Blondet, Rima Fawaz, Silvia Nastasio, Pier Luigi Calvo, Gabriella Nebbia, Cigdem Arikan, Catherine Larson-Nath, Andréanne N. Zizzo, Thomas Damgaard Sandahl, Christos Tzivinikos, Nehal M. El-Koofy, Mohamed A. Elmonem, Amal A. Aqul, Wikrom Karnsakul, Pinar Bulut, Nanda Kerkar, Victorien M. Wolters, Amin J. Roberts, Helen M. Evans, Maria Camila Sanchez, Maria Lorena Cavalieri, Deirdre A. Kelly, Jane Hartley, Way Seah Lee, Christina Hajinicolaou, Chatmanee Lertudomphonwanit, Ryan T. Fischer, Jesus Quintero Bernabeu, Ruben E. Quiros-Tejeira, Cristina Targa Ferreira, Elisa Carvalho, John Eshun, Aglaia Zellos, Antal Dezsőfi, Raquel Borges Pinto, Kathleen Schwarz, Maria Rogalidou, Jennifer Garcia, María Legarda Tamara, Marisa Beretta, Quais Mujawar, Ermelinda Santos-Silva, Cristina Molera Busoms, Eberhard Lurz, Cristina Gonçalves, Carolina Jimenez-Rivera, Jesus M. Banales, Richard J. Thompson, Bettina E. Hansen, Binita M. Kamath, Global Alagille Alliance (Gala) Study Group
Elevated Serum Bile Acids Predict Poor Liver Outcomes In Children With Alagille Syndrome: Results From The Gala Study Group., Carla Fiorella Murillo Perez, Shannon M. Vandriel, Emmanuel M. Gonzales, Jian-She Wang, Li-Ting Li, Huiyu She, Irena Jankowska, Piotr Czubkowski, Dorota Gliwicz-Miedzińska, Emmanuel Jacquemin, Jérôme Bouligand, Lorenzo D'Antiga, Emanuele Nicastro, Björn Fischler, Henrik Arnell, Susan M. Siew, Michael Stormon, Kathleen M. Loomes, David A. Piccoli, Elizabeth B. Rand, James E. Squires, Saul J. Karpen, Rene Romero, Mureo Kasahara, Zerrin Önal, Étienne Sokal, Tanguy Demaret, Sabina Wiecek, Florence Lacaille, Dominique Debray, Winita Hardikar, Sahana Shankar, Pamela L. Valentino, Shikha S. Sundaram, Noelle H. Ebel, Jeffrey A. Feinstein, Orith Waisbourd-Zinman, Henry C. Lin, Nathalie Rock, Henkjan J. Verkade, M Kyle Jensen, Catalina Jaramillo, Kyung Mo Kim, Seak Hee Oh, Jernej Brecemiclj, Seema Alam, Giuseppe Indolfi, Niviann Blondet, Rima Fawaz, Silvia Nastasio, Pier Luigi Calvo, Gabriella Nebbia, Cigdem Arikan, Catherine Larson-Nath, Andréanne N. Zizzo, Thomas Damgaard Sandahl, Christos Tzivinikos, Nehal M. El-Koofy, Mohamed A. Elmonem, Amal A. Aqul, Wikrom Karnsakul, Pinar Bulut, Nanda Kerkar, Victorien M. Wolters, Amin J. Roberts, Helen M. Evans, Maria Camila Sanchez, Maria Lorena Cavalieri, Deirdre A. Kelly, Jane Hartley, Way Seah Lee, Christina Hajinicolaou, Chatmanee Lertudomphonwanit, Ryan T. Fischer, Jesus Quintero Bernabeu, Ruben E. Quiros-Tejeira, Cristina Targa Ferreira, Elisa Carvalho, John Eshun, Aglaia Zellos, Antal Dezsőfi, Raquel Borges Pinto, Kathleen Schwarz, Maria Rogalidou, Jennifer Garcia, María Legarda Tamara, Marisa Beretta, Quais Mujawar, Ermelinda Santos-Silva, Cristina Molera Busoms, Eberhard Lurz, Cristina Gonçalves, Carolina Jimenez-Rivera, Jesus M. Banales, Richard J. Thompson, Bettina E. Hansen, Binita M. Kamath, Global Alagille Alliance (Gala) Study Group
Manuscripts, Articles, Book Chapters and Other Papers
BACKGROUND AND AIM: Alagille syndrome (ALGS) is a rare disorder characterised by cholestasis and extrahepatic manifestations. Given the current era of ileal bile acid transporter (IBAT) inhibitor therapies that reduce serum bile acid (SBA) levels, we evaluated whether SBA predicts liver disease outcomes in ALGS.
METHODS: Patients were ascertained from the Global ALagille Alliance (GALA) cohort. A prognostic threshold of SBA 102 μmol/L was assessed as a time-dependent covariate in Cox regression analyses for native liver survival (NLS) and event-free survival (EFS), while adjusting for total bilirubin (TB) levels.
RESULTS: 570 GALA patients were included (348 [61%] male). There was …
Clinical Long-Read Sequencing Test For Genetic Disease Diagnosis., Isabelle Thiffault, Emily G. Farrow, Cassandra Barrett, Meadow Scott, Amy Ross, John C. Means, Warren A. Cheung, Adam F. Johnson, Boryana Koseva, Rebecca Mclennan, Elin Grundberg, Chengpeng Bi, Carl F. Schreck, Byunggil Yoo, Jeffrey J. Johnston, Florencia Del Viso, Vitoria Paolillo, John Herriges, Lei Zhang, Margaret Gibson, Ana S A Cohen, Joseph Alaimo, Carol J. Saunders, Tomi Pastinen
Clinical Long-Read Sequencing Test For Genetic Disease Diagnosis., Isabelle Thiffault, Emily G. Farrow, Cassandra Barrett, Meadow Scott, Amy Ross, John C. Means, Warren A. Cheung, Adam F. Johnson, Boryana Koseva, Rebecca Mclennan, Elin Grundberg, Chengpeng Bi, Carl F. Schreck, Byunggil Yoo, Jeffrey J. Johnston, Florencia Del Viso, Vitoria Paolillo, John Herriges, Lei Zhang, Margaret Gibson, Ana S A Cohen, Joseph Alaimo, Carol J. Saunders, Tomi Pastinen
Manuscripts, Articles, Book Chapters and Other Papers
This diagnostic study examines the diagnostic yield and turnaround time of long-read sequencing compared to standard-of-care approaches.
Requirement Of Prepiilin Peptidase Activity For Variovorax Paradoxus Eps Flp/Fap Pilus Assembly, Jenny L. Lanthripp
Requirement Of Prepiilin Peptidase Activity For Variovorax Paradoxus Eps Flp/Fap Pilus Assembly, Jenny L. Lanthripp
Electronic Theses, Projects, and Dissertations
Variovorax paradoxus is a Gram-negative aerobic bacterium present in both soil and the human oral microbiome. This species contributes to biotransformation of xenobiotics and promotes plant growth. Interestingly, although the genome of strain EPS lacks the flagellum operon annotated in strain S110, the microbe remains motile, and flagella can be observed microscopically. To investigate this unexpected phenotype, motility mutants were enriched from a Tn5 mutant library using a liquid culture settling strategy. A total of 122 isolates were screened for motility defects, and 57 exhibited significantly reduced motility compared to the wild type. Rescue cloning revealed that over 60% of …
Potential Adverse Effects On Lifestyle And Food Intake Pattern In Night Shift Workers, Stacie L. Coleman
Potential Adverse Effects On Lifestyle And Food Intake Pattern In Night Shift Workers, Stacie L. Coleman
Electronic Theses, Projects, and Dissertations
Abstract
Night shift work is prevalent in healthcare and other industries, yet its effects on lifestyle factors such as food intake, sleep quality, and mental health remain underexplored. This study investigates the impact of night shift schedules on nurses’ wellness, focusing on eating patterns, sleep, physical activity, and mood. A sample of 13 nurses were divided into two shift groups: day (n=5) and night (n=8); and they completed a questionnaire to assess the variables related to their behavior, food choices, eating habits, sleep patterns.
The results of previous research studies indicate that night shift nurses are more likely to adopt …
Experimental Characterization Of An Additively Manufactured Porous Gyroid Air-Cooled Heat Sink, Grant S. Resler
Experimental Characterization Of An Additively Manufactured Porous Gyroid Air-Cooled Heat Sink, Grant S. Resler
Mechanical Engineering Undergraduate Honors Theses
This paper presents the development of a ducted test facility designed to evaluate heat sinks efficiency at varying air velocities. This enables the evaluation of both heat transfer and pressure drop performance. These metrics are essential to the overall efficiency of heat sinks and help identify the optimal air velocity to achieve the desired thermal performance. A standard plate fin heat sink was used as a control for comparison to a novel heat sink. The specialized heat sink geometry was generated using nTop, a generative design software focused on additive manufacturing. This design was fabricated via Direct Metal Laser Sintering …
Leveraging Virtual Reality In Nursing Education To Enhance Confidence And Knowledge, Kerry Vaccaro, Amanda Bodinet, Concetta Zak
Leveraging Virtual Reality In Nursing Education To Enhance Confidence And Knowledge, Kerry Vaccaro, Amanda Bodinet, Concetta Zak
Biennial Convention (CONV)
Blood transfusion reactions can be life threatening and are rarely encountered by nursing students in clinicals. Simulation has been shown to have a positive impact on transfusion-related competence in nursing students (Brown, C. & Brown, M., 2023). BSN nursing students faced challenges in recognizing and responding to blood transfusion reactions. A Virtual Reality (VR) simulation was introduced as an innovative teaching modality. Virtual Reality provides learners with a more life-like experience that is standardized and safe (Kiegaldie & Shaw, 2023). The purpose of this study was to evaluate whether VR simulation, compared to traditional lecture, improves senior-level BSN students' confidence …
Advanced Practice Provider (App) Midline Training Initiative, Al-Zada Aguilar, Sarah D. Maute
Advanced Practice Provider (App) Midline Training Initiative, Al-Zada Aguilar, Sarah D. Maute
Biennial Convention (CONV)
Temporary, non-tunneled central venous catheters (CVCs) are commonly used for vascular access in patients with vesicant infusion needs or difficult intravenous access (DIVA). However, CVCs are associated with primary bloodstream infections (BSIs), contributing to significant morbidity, mortality, and financial burdens. At our institution, central line-associated bloodstream infection (CLABSI) rates and central utilization ratios have steadily increased since 2023, rising from 0.43 to 0.75 and 0.17 to 0.21, respectively, despite system-wide infection prevention initiatives. Recognizing the limitations of current approaches, particularly for DIVA patients, midlines emerged as an alternative to both CVCs and ultrasound-guided peripheral IVs (USG-PIVs).
In response, a multimodal …
Integrating Telehealth Innovation To Advance Emergency Department Flow And Nursing-Led Care, Patrice Callagy, Maria Cheung
Integrating Telehealth Innovation To Advance Emergency Department Flow And Nursing-Led Care, Patrice Callagy, Maria Cheung
Biennial Convention (CONV)
Purpose: Efficient patient flow is critical for managing capacity and delivering timely, equitable care in emergency departments (EDs). As patient acuity and census increased at Stanford Health Care (SHC), traditional Fast Track spaces were reassigned to higher-acuity patients, leaving lower-acuity patients with prolonged lengths of stay (LOS). Prolonged LOS increases the risk of patients leaving without treatment, impacting care outcomes. To address this, SHC’s Digital Health team and Emergency Services leadership developed an innovative Virtual Fast Track care framework using telehealth technology and multidisciplinary workflows.
Methods: This novel approach applies an "inverted telemedicine" model in which care is provided within …
Sustaining The Future Workforce With What Matters Most To Nurses, Deirdre O'Flaherty
Sustaining The Future Workforce With What Matters Most To Nurses, Deirdre O'Flaherty
Biennial Convention (CONV)
Introduction: Meaningful recognition confirms the value of nurses’,environments that acknowledge this influence a healthy workplace. Applying quadruple aim framework, optimizing healthcare system outcomes places wellbeing in the forefront and supports fostering resilience, hardiness, interprofessional collaboration and engagement, augmenting the work setting.
Objectives: Discussing strategies, interprofessional collaboration, engagement, fortified resilience, empowered staff and have brought value and meaning to nurses. This study compares peer-reviewed literature on the impact of leadership styles, organization culture and support among nurse managers.
Methods: We previously studied and analyzed clinical nurses’ and nurses in leadership positions perceptions of resilience, empowerment and pre-pandemic engagement. Results …
Goodbye Textbook: Content Creation For A Non-Clinical Nursing Course Using Ai Tools, Julie Kientz Elting
Goodbye Textbook: Content Creation For A Non-Clinical Nursing Course Using Ai Tools, Julie Kientz Elting
Biennial Convention (CONV)
Purpose: To provide guidance for faculty interested in creating materials using AI tools for nursing courses which allows ‘unadoption’ of textbooks.
Background: When discussing AI text generation tools like ChatGPT and Gemini (AI tools), many nursing faculty are only aware of the risks to academic writing (Abujaber et al., 2023). But there are many pedagogical benefits of AI tools that enhance student learning (Elting & Desio, 2024; Glauberman et al., 2023; Srinivasan et al., 2024) and manage faculty teaching, communication, and administrative tasks (Srinivasan et al., 2024). What is less known is how AI tools can be used to create …
Repealing Reorgs, Reuven S. Avi-Yonah
Repealing Reorgs, Reuven S. Avi-Yonah
Law & Economics Working Papers
Under the Supreme Court's opinion in Moore, it is likely that realization is essential for defining income as a constitutional matter. Therefore, when a transaction involves realization, it should presumptively be taxable unless there are very good reason for nonrecognition of gain. Given this reality, there are good reasons for Congress to consider repealing tax-free reorganizations and the other nonrecognition rules of the corporate tax, primarily for non-tax reasons. Acquisitive A, B, and C reorganizations and acquisitive section 351 transactions typically are used for large public corporations to acquire startups, which encourages monopolies. Triangular mergers raise corporate governance concerns …
Dual-Level Pattern Tree For Visual Field Improves Glaucoma Progression And Polygenic Risk Prediction, Luo Song, Lucy Q. Shen, Louis R. Pasquale, Michael V. Boland, Sarah R. Wellik, Carlos Gustavo De Moraes, Ayellet Segre, Janey L. Wiggs, Constance Turman, Jonathan S. Myers, Tobias Elze, Nazlee Zebardast, David S. Friedman, Jae H. Kang, Mengyu Wang
Dual-Level Pattern Tree For Visual Field Improves Glaucoma Progression And Polygenic Risk Prediction, Luo Song, Lucy Q. Shen, Louis R. Pasquale, Michael V. Boland, Sarah R. Wellik, Carlos Gustavo De Moraes, Ayellet Segre, Janey L. Wiggs, Constance Turman, Jonathan S. Myers, Tobias Elze, Nazlee Zebardast, David S. Friedman, Jae H. Kang, Mengyu Wang
Wills Eye Hospital Papers
PURPOSE: To develop a dual-level pattern tree to characterize visual field (VF) loss subtypes that can be used to better predict glaucoma progression and glaucoma polygenic risk scores (PRSs).
METHODS: This study included 113,030 patients from three datasets, each used for a specific purpose: (1) model training, (2) progression forecasting, and (3) PRS correlations. We applied archetypal analysis to cluster 24-2 VFs into trunk patterns and their branch patterns. The Cox regression model was used to forecast VF progression using mean deviation (MD) slope, MD-fast slope, total deviation (TD) pointwise slope, and visual field index (VFI) slope. Multivariable regression analyses …
Acute Effects Of Lactate Infusion On Metabolism, Ad Biomarkers, And Cognition, Riley E. Kemna, Paul J. Kueck, Anneka Blankenship, Casey S. John, Chelsea N. Johnson, Zachary D. Green, Hana Mayfield, Lauren Yoksh, Lance Johnson, John P. Thyfault, Jonathan D. Mahnken, Benjamin F. Miller, Jill K. Morris
Acute Effects Of Lactate Infusion On Metabolism, Ad Biomarkers, And Cognition, Riley E. Kemna, Paul J. Kueck, Anneka Blankenship, Casey S. John, Chelsea N. Johnson, Zachary D. Green, Hana Mayfield, Lauren Yoksh, Lance Johnson, John P. Thyfault, Jonathan D. Mahnken, Benjamin F. Miller, Jill K. Morris
Physiology Faculty Publications
BACKGROUND: Impaired cerebral glucose metabolism is a hallmark of Alzheimer's disease (AD). Lactate is an alternative brain fuel; however, whole-body lactate metabolism has not been measured in AD. METHODS: The Lactate for Energy and Neurocognition Trial (NCT05207397) was a single-arm trial that enrolled 24 cognitively healthy (CH) older adults and 12 cognitively impaired (CI) participants. Subjects underwent a stable isotope lactate infusion to evaluate lactate metabolism, cognitive testing, and blood biomarker analyses. pTau217, brain-derived tau (BD-tau), pTau181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), total tau, and brain-derived neurotrophic factor (BDNF) were analyzed by Simoa HD-X (Quanterix). RESULTS: …
Direct Measurement Of Mavacamten And Deoxyatp Perturbation Of The Srx/Drx Ratio In Porcine Cardiac Myofibrils Using A Simple, Accessible And Multiplexed Approach, Matvey Pilagov, Ateeqa Naim, Kenneth S. Campbell, Thomas Kampourakis, Michael A. Geeves, Neil M. Kad
Direct Measurement Of Mavacamten And Deoxyatp Perturbation Of The Srx/Drx Ratio In Porcine Cardiac Myofibrils Using A Simple, Accessible And Multiplexed Approach, Matvey Pilagov, Ateeqa Naim, Kenneth S. Campbell, Thomas Kampourakis, Michael A. Geeves, Neil M. Kad
Physiology Faculty Publications
Cardiac muscle adapts to varying physiological demands by modulating the number of active myosin II motors available for contraction. These motors are organized into thick filaments in the sarcomere and generate force through an ATP-dependent interaction with thin filaments that contain actin. To conserve energy, when demand is low myosin can occupy the super-relaxed (SRX) state, which acts as a reserve. Here, we build upon the earlier studies to quantify the size of this cardiac reserve using fluorescence imaging of Cy3-ATP directly in myofibrils. This approach employs a pulse-chase method and exploits the high permeability of isolated myofibrils to monitor …
Inhibition Of Astrocyte Signaling Leads To Sex-Specific Changes In Microglia Phenotypes In A Diet-Based Model Of Cerebral Small Vessel Disease, Jenna L. Gollihue, Khine Zin Aung, Colin B. Rogers, Leopoldine B. Galopin, Nicholas A. Wright, Pradoldej Sompol, Erica M. Weekman, Yuriko Katsumata, Josh M. Morganti, Christopher M. Norris
Inhibition Of Astrocyte Signaling Leads To Sex-Specific Changes In Microglia Phenotypes In A Diet-Based Model Of Cerebral Small Vessel Disease, Jenna L. Gollihue, Khine Zin Aung, Colin B. Rogers, Leopoldine B. Galopin, Nicholas A. Wright, Pradoldej Sompol, Erica M. Weekman, Yuriko Katsumata, Josh M. Morganti, Christopher M. Norris
Physiology Faculty Publications
Hyperhomocysteinemia (HHcy)-inducing diets recapitulate cerebral small vessel disease phenotypes in mice including cerebrovascular pathology/dysfunction, neuroinflammation, synaptic deficits, and cognitive decline. We recently showed that astrocyte signaling through calcineurin(CN)/nuclear factor of activated T cells (NFATs) plays a causative role in these phenotypes. Here, we assessed the impact of astrocytic signaling on microglia, which set the inflammatory tone in brain. Seven-to-eight-week-old male and female C57BL/6 J mice received intrahippocampal injections of adeno-associated virus (AAV) expressing EGFP (AAV2/5-Gfa2-EGFP) or AAV expressing the NFAT inhibitor VIVIT (i.e., AAV2/5-Gfa2-VIVIT-EGFP). Mice were then fed with control chow (CT) or B-vitamin-deficient chow for 12 weeks to induce …
Micro/Nanomechanical Properties Of Top-Seeded Melt Grown Ybco Single Crystals Determined Using Depth Sensing Indentation, Ugur Kolemen, Cafer Mert Yesilkanat, Fikret Yilmaz, Fatih Dogan, Orhan Uzun
Micro/Nanomechanical Properties Of Top-Seeded Melt Grown Ybco Single Crystals Determined Using Depth Sensing Indentation, Ugur Kolemen, Cafer Mert Yesilkanat, Fikret Yilmaz, Fatih Dogan, Orhan Uzun
Materials Science and Engineering Faculty Research & Creative Works
Mechanical properties of the bulk YBa2Cu3O7-x (YBCO) single crystal superconductor, prepared by using the Top Seeded Melt Growth (TSMG) method, were determined. Property measurements were conducted by the nanoindentation method under various loads and the micro indentation method at different temperatures. Hardness (H) and reduced elastic modulus (Er) values were calculated by using the Oliver–Pharr method. According to hf/h max values found from load- displacement curves, there is a sink in behavior around outer rim of the indents that was confirmed by atomic force microscopy (AFM) analysis. Nanoindentation analyses conducted on upper section, middle section and subsection revealed that all …
Best Practices: Lean Thinking For Corn And Soybean Farmers, Tomas Gutierrez, Henry Quesada
Best Practices: Lean Thinking For Corn And Soybean Farmers, Tomas Gutierrez, Henry Quesada
Purdue Extension Numbered Publications
This article presents a practical introduction to lean thinking for corn and soybean farmers. Lean is a proven management approach that helps reduce waste, organize workspaces and improve the use of time, tools, and materials. Although it began in manufacturing, lean has been successfully adapted to agriculture through simple, low-cost tools that focus on improving everyday tasks.
The guide explains six key lean tools — 5S, Kanban, Visual Controls, TPM, Standardization, and Kaizen — with real farm examples and step-by-step recommendations. It also offers advice on how to get started, involve workers and measure improvements using basic indicators.
Lean thinking …
Digital Literacy And Family Engagement For Student Success, Genesis B. Mendoza
Digital Literacy And Family Engagement For Student Success, Genesis B. Mendoza
Capstone Projects and Master's Theses
The North Monterey County Unified School District (NMCUSD) in Castroville, California, serves a student population in which 87.5% are identified as low-income and nearly half are designated as English Language Learners. Families face significant barriers to accessing educational and community resources, barriers worsened by limited digital literacy and technology access. The NMCUSD Castro Plaza Family Resource Center serves as a vital hub supporting families in the predominantly rural and socioeconomically disadvantaged region. This project aimed to strengthen family engagement and digital inclusion through hands-on workshops. Workshop topics included online student registration and data verification, training on essential district digital tools …
An Analytical Assessment Of Sentiment Analysis Trends And Methods Through Systematic Review And Topic Modeling, Chelsey Hill, Fatima Irshaidat, Marina Johnson, Jorge Fresneda
An Analytical Assessment Of Sentiment Analysis Trends And Methods Through Systematic Review And Topic Modeling, Chelsey Hill, Fatima Irshaidat, Marina Johnson, Jorge Fresneda
Department of Information Management and Business Analytics Faculty Scholarship and Creative Works
Sentiment Analysis (SA) applies Artificial Intelligence (AI) and Machine Learning (ML) techniques to identify and interpret opinions, emotions, and sentiment polarity in text data. This study presents a systematic literature review of SA research published between 2012 and 2024 using a dataset of 14,482 journal articles indexed in Scopus. The primary objective of this research is to provide a data-driven overview of the evolution of SA research, offering insights into methodological evolutions, emerging application areas, and the growing influence of AI in the field. The research findings reveal a multidisciplinary growth of SA research, with increasing contributions from Health Sciences …
The Wisdom Of The Lexicon Crowds: Leveraging On Decades Of Lexicon-Based Sentiment Analysis For Improved Results, Chelsey H. Hill, Jorge E. Fresneda, Murugan Anandarajan
The Wisdom Of The Lexicon Crowds: Leveraging On Decades Of Lexicon-Based Sentiment Analysis For Improved Results, Chelsey H. Hill, Jorge E. Fresneda, Murugan Anandarajan
Department of Information Management and Business Analytics Faculty Scholarship and Creative Works
The “wisdom of the crowd” (WoC) refers to the notion that collective human knowledge is capable of outperforming even individual expert knowledge. This study investigates the application of this phenomenon to lexicon-based sentiment analysis of text data. Lexicons are frequently used to classify the sentiment of text data, particularly in the absence of sentiment class label information. We propose leveraging some of the most popular, publicly-available lexicons created in the last half century to improve sentiment analysis performance. Specifically, this research argues that the collective information provided by the thirteen lexicons included in the crowd constitutes a WoC situation that …
Injury Prevention And Care Training Website, Samantha E. Myers
Injury Prevention And Care Training Website, Samantha E. Myers
Theses/Capstones/Creative Projects
Injury Prevention and Care is a University of Nebraska Omaha (UNO) resource within Campus Recreation and Wellness. It serves a variety of students, staff, , and other membership holders with a variety of resources and treatments in caring for injuries and in seeking to prevent new or worsening of injuries. In facilitating the health and growth of this department and their staff, updating the current training resources, and making them more accessible was necessary. Moving forward, discussions of the importance of accessibility and providing various resources, both in IPC and across the UNO campus, were pivotal in the formation and …