Digital Commons Network^™

Yap-Induced Glycolysis Drives Fibroinflammation And Disrupts Fibroblast Fidelity, Jong H Kim, Paulo Czarnewski, Rich Gang Li, Fansen Meng, Mingjie Zheng, Jeffrey Steimle, Xiaolei Zhao, Francisco Grisanti, Zheng Sun, Jun Wang, Md Abul Hassan Samee, Xiao Li, James F Martin

Faculty, Staff and Students Publications

Background: Separation of the pulmonic and systemic circulation is essential for terrestrial life, and mammals have evolved distinct cardiac chambers with specialized structures and functions. Transcriptomics profiling revealed cellular heterogeneity between heart chambers. However, the mechanisms underlying chamber-specific transcriptomic and metabolic differences-and their functional significance-remain poorly understood. The Hippo/YAP (yes-associated protein) pathway is a conserved signaling network that regulates diverse cellular processes. The Hippo kinases inhibit YAP in cardiac fibroblasts (CF) to restrict fibrosis and inflammation. Nonetheless, how YAP regulates the metabolic microenvironment during homeostasis and fibroinflammation remains unclear.

Methods: We investigated YAP and glycolysis activity in the 4 cardiac …

Periodontal Precision: Diagnostic Skills And Confidence Of Dentists In Asian Countries In Applying The 2017 Efp/Aap Periodontal Disease Classification- A Cross-Sectional Pilot Study, Kamran Ali, Priti Charde, Daniel Zahra, Ewen Mccoll, Tayeb Al Hadeethi, Nader Hamdan

Peninsula Dental School

Background: The classification of periodontal disease published in 2017 by the European Federation of Periodontology (EFP) and American Academy of Periodontology (AAP), provides a framework for diagnosis and treatment. The aim of this study was to evaluate the diagnostic skills and self-perceived confidence of dentists and dental students based in Asian countries in the use of this classification. Methods: A cross-sectional analytic study design was employed. An online questionnaire encompassing four periodontitis cases was used for data collection. A total of 500 participants were invited to provide a diagnosis and rate their confidence for each case. Results: Responses were provided …

Increased Intermembrane Space [Ca2+] Drives Mitochondrial Structural Damage In Cpvt, Shanna Hamilton, Radmila Terentyeva, Roland Veress, Fruzsina Perger, Zuzana Nichtova, Mark Bannister, Jinxi Wang, Sage Quiggle, Rachel Battershell, Matthew Gorr, Sandor Györke, Bum-Rak Choi, Christopher George, Andriy Belevych, György Csordás, Dmitry Terentyev

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Mitochondrial dysfunction caused by abnormally high RyR2 (ryanodine receptor) activity is a common finding in cardiovascular diseases. Mechanisms linking RyR2 gain of function with mitochondrial remodeling remain elusive. We hypothesized that RyR2 hyperactivity in cardiac disease increases [Ca 2+ ] in the mitochondrial intermembrane space (IMS) and activates the Ca 2+ -sensitive protease calpain, driving remodeling of mitochondrial cristae architecture through cleavage of structural protein OPA1 (optic atrophy protein 1).

METHODS: We generated a highly arrhythmogenic rat model of catecholaminergic polymorphic ventricular tachycardia, induced by RyR2 gain-of-function mutation S2236L(Ser2336Leu)(+/-) . We created a new biosensor to measure IMS-[Ca2+ ] …

Synergistic Potential Of Sipuleucel-T In Enhancing Immunotherapy For Metastatic Castration-Resistant Prostate Cancer, Kavita Rawat, Varnika Punia, Parker Mathews, Sara Mccoy, Wilbur Song, Muhammad A Saeed, Russell K Pachynski

2020-Current year OA Pubs

Clinical trials of immunotherapy in metastatic castration-resistant prostate cancer (mCRPC) have largely been unsuccessful despite promising preclinical studies and proven efficacy in other solid tumors. These disappointing clinical outcomes have been attributed to an immunosuppressive tumor microenvironment, a relative lack of infiltrating immune effector cells, and tumor-related and host-related factors, which collectively render prostate cancer a relatively immunologically "cold" tumor. Sipuleucel-T (Provenge), an autologous cellular immunotherapy, induces an immune response targeted against prostatic acid phosphatase. It received approval from the US Food and Drug Administration in 2010, marking the first immunotherapy to show an overall survival benefit in patients with …

Functional Vs Anatomical Cortico-Striatal Connectivity In The Macaque Brain, Ana M G Manea, Fernando A Ortega, Damyan Hart, Jason Zhou, Jan Zimmermann, Sarah R Heilbronner

Faculty, Staff and Students Publications

The cerebral cortex provides the main input to the striatum, constituting the first step in cortico-basal ganglia loops. Decades of careful anatomical tract-tracing research have established the exquisite topography of each cortical region's projection to the striatum in nonhuman primates. In parallel, neuroimaging research has demonstrated the relationship between cortico-striatal resting-state functional connectivity and specific cognitive, behavioral, psychiatric, and neurological states in humans. However, still unclear is the extent to which functional connectivity recapitulates the specific topographies of cortico-striatal anatomical connectivity. Here, we combined datasets of cortico-striatal anatomical and functional connectivity in macaques to determine the degree of overlap between …

A Mouse Model Of Lipoatrophy Reveals Relationships Between Beige Fat Appearance And Female Fertility, Aaron R Cox, Evelyn De Groot, Avery A Ahmed, Jessica B Felix, Bokai Zhu, Stephanie A Pangas, Sean M Hartig

Faculty, Staff and Students Publications

White adipose tissue (WAT) performs vital metabolic and endocrine functions, but roles in female reproduction remain understudied and poorly understood. Here, we report that female mice experiencing progressive lipoatrophy after knockout of Ubc9 in adipocytes (Ubc9fKO) displayed disrupted estrous cycles, reduced ovarian reserve, and subfertility. During aging, female Ubc9fKO mice lose subcutaneous WAT more quickly than their male counterparts and weigh less than littermate controls. Subcutaneous WAT excised from female Ubc9fKO mice strongly enriched for thermogenesis genes generally associated with metabolic benefits. Female Ubc9fKO mice exhibited hypermetabolism and accumulated thermogenic, Uncoupling Protein 1-expressing beige fat cells in residual subcutaneous WAT …

Perception Of Veterans With Traumatic Brain Injury Regarding The Veterans Administration Rehabilitation Process, Kalangie J. Serrano

Walden Dissertations and Doctoral Studies

There was a social work practice gap on the perceptions of veterans with traumatic brain injury (TBI) regarding the Veterans Administration's (VA’s) rehabilitation process in terms of its ability to enhance their vocational skills and employability. The purpose of this qualitative study was to explore the vocational and employment needs of military veterans with TBI and to understand their perceptions and challenges in navigating the vocational rehabilitation and employment process. Using a generic qualitative approach and ecological systems theory, data were collected through semistructured interviews with seven veterans who had participated in rehabilitation programs. Thematic analysis of the data revealed …

Effective Strategies To Attract And Retain Qualified Hospitality Staff In The Post-Pandemic Caribbean, Rajan Bhattarai

Walden Dissertations and Doctoral Studies

Employee attraction and retention remain critical constraints for Caribbean luxury-wellness resorts in the post-pandemic era. Hospitality and tourism leaders are concerned because persistent vacancy, churn, and extended time-to-competence impair service quality and performance of their organizations. Grounded in the Baldrige Excellence Framework and social exchange theory, the purpose of this qualitative single case study was to explore the effective strategies employed by tourism leaders to attract and retain qualified staff within a Caribbean hospitality organization. Data were collected from five Caribbean leaders (HR director, department manager, and supervisors) using semistructured interviews and analyzing organizational documents. Thematic analysis was used to …

The Making Of Constantinople Ii: Reception And Renewal Of Conciliar Christology, A.D. 428–553, Joshua Miller

Dissertations (1934 -)

The Second Council of Constantinople in 553, recognized by many Christian traditions as the fifth ecumenical council, represents a pivotal moment in the development and articulation of the Church’s understanding of the central mystery of her faith, that of the Incarnation of the Word of God who is Jesus Christ. Constantinople II provides a clarification of the symmetrical statement of Christology produced at the Council of Chalcedon in 451 by reading it in continuity with the preceding conciliar tradition, especially the Council of Ephesus in 431, and by retrieving neglected tenets of Cyril of Alexandria’s more asymmetrical account of Christology, …

School And District Leaders’ Understanding Of Technology Organizations’ Cyber Business Practices, Jayejaye Johnson

Journal of Educational Research and Practice

Educational technology (EdTech) interoperability throughout cyberspace provides the financial opportunity to collect and sell student privacy information in digital learning environments, challenging school leaders to govern schools and keep children safe. School leaders provide the resources, funding, planning, decision making, and administration for EdTech cybersecurity practices and policies, yet little is known about what public school leaders understand. A quantitative study was designed using primary data collected from an online survey. Four research questions guided this study: What are the differences in cybersecurity practices and policy response scores (1) between male and female school leaders; (2) among leaders with different …

Child Assent Practices In Research: Improving Ethics, Decision-Making, And Inclusivity, David C. Coker, Ketaki Inamdar, Daniel F. Mccleary, Lesley Cottrell

Journal of Educational Research and Practice

The following article addresses a conundrum: What if child assent in research were a fully informed, stand-alone process that empowered all children to discuss meaningfully, negotiate, and decide how and what the research experience would look like? Past research and practices suggest that child assent, when children (youths to 17-year-olds who have not been emancipated) agree to participate in research before, during, and after parents’ or guardians’ consent, is rife with problems that minimize informed participation and prize procedural ethics over true understanding of the processes and autonomous decision-making. Academic articles often lack details, as length requirements and brevity preclude …

Estate Planning Techniques: Disclaimer-A Useful Post-Mortem Estate Planning Tool, Philip E. Heckerling

Tax Adviser

No abstract provided.

Extensions And Expansions Of Ubit, Levon C. Register

Tax Adviser

No abstract provided.

Wired Differently, Not Broken, Abdullah Imran

Showcase of Scholars

No abstract provided.

Create @ State 2011, Arkansas State University - Jonesboro

Create@State

The proceedings book for 2011

Enrolled Deeds As Records And Archives In Jamaica, Andrew Williams

Journal of Contemporary Archival Studies

This paper examines the history of the enrolled deeds record series in Jamaica, from its creation in the mid-seventeenth century through to the present day. It is a critical examination of a single record series through colonialism and independence. It examines the purpose of deeds and the context in which deeds registries were created before examining the history of the series through the periods of slavery and emancipation. It examines in close detail the late nineteenth century, when the Island Record Office—which has custody of the enrolled deeds—was created and several other important changes happened. It situates the enrolled deeds …

Enhancing Archives And Records Management In Low-Resourced Organizations Through Experiential Learning, Jinfang Niu

Journal of Contemporary Archival Studies

Master’s students in Archives and Records Management could help low-resourced organizations address their Archives and Records Management needs while gaining practical experience. Archives and Records Management education programs could facilitate this mutually beneficial relationship by offering internships and service-learning courses. This paper analyzes the strengths and limitations of these two experiential learning mechanisms and discusses solutions to overcome the limitations. It argues that service-learning is especially suitable for addressing the Archives and Records Management needs of low-resourced organizations and proposes a service-learning model for that purpose.

Student-Designed Archival Pedagogy: A Workshop-As-Research Approach To Pluralizing Community Archives Education, Magdalena Wiśniewska-Drewniak

Journal of Contemporary Archival Studies

Community archives are becoming an increasingly important component of the heritage landscape, as well as an observable part of university archival education. This article is part of a research project titled “Teaching about Community Archives in the US and Poland--A Comparative Study” conducted by the author between March and May 2024. Using the student-centered learning approach, the article analyzes a workshop conducted with US-based students on the design of university courses on community archives. The designs included course audience, learning outcomes, course content, grading methods, and possible challenges. The article identifies four groups of learning outcomes (directions of community archives …

Archival Notations Of The Norwegian Charter Material, Juliane Tiemann

Journal of Contemporary Archival Studies

This paper explores archival notations, primarily from the early modern and modern periods, found on the dorse of Norwegian charters dating from the 13th to the 17th century. By examining the notation practices of two prominent Norwegian archivists and collectors, the study further highlights individual efforts in documenting and preserving these materials across various collections. The archival efforts are contextualized historically, noting a transition to systematic archival management. The findings reveal the significance of this largely unexplored component of Norwegian charters as additional historical sources, emphasizing the role of dorsal annotations in provenance research. The textual and visual analysis of …

Combating Financial Corruption In The Light Of The Prophetic Hadith: An Analytical And Rhetorical Study, Manaa Rajeh Saad Alghamdi

UB Journal for Humanities

This study clarifies the rhetorical qualities and artistic dimensions of the Prophet Muhammad’s eloquence in Hadiths cautioning against the unlawful appropriation of wealth, aimed at combating widespread financial corruption in society. Using a descriptive-analytical approach, the research addresses two main questions: How is language employed to counter financial corruption, and how do the Prophet’s expressive modes vary within this context? Through a detailed rhetorical analysis of relevant Hadiths framed by a unifying thematic perspective, the study reveals the subtle intricacies of these expressions. The research is structured into an introduction and four sections that discuss the Prophet’s eloquence on bribery, …

Semiotics Of The Identity Of The Saudi National Day Slogan During The Reign Of King Salman Bin Abdulaziz, Norah Saad Mohammed Al-Shahrani

UB Journal for Humanities

This research analyzes the semiotics of the visual identity of the Saudi National Day during the reign of King Salman bin Abdulaziz. It aims to analyze the semantic and value dimensions associated with Saudi society and its cultural and civilizational contextual components through the structural elements of the logo: the visual and iconic on the one hand, and the linguistic on the other. The investigation also measures the transformations and changes in the structure of the logo and its advertising production that have evolved over the past nine years. The research utilized semiotic analysis of the logo to explore the …

The Jurisprudential Rulings Related To The Metal Palladium And Its Ownership In The Legal System Of The Kingdom Of Saudi Arabia: A Comparative Jurisprudential Study, Abdullah Ayed Abdulhadi

UB Journal for Humanities

This research presents a comparative jurisprudential study on the rulings related to the metal palladium and its ownership under the legal system of the Kingdom of Saudi Arabia. The study is divided into three sections. The first section provides definitions of the key terms. In the second section, the researcher addresses jurisprudential rulings related to religious practices, such as the use of palladium utensils for ablution and the Zakat of palladium, presenting different scholarly views, their evidence, and the most correct opinion. The third section covers rulings related to transactions, including ownership of palladium if found on private land. The …

Ethical Guidelines For Male Interaction With Non-Mahram Women Through The Questions Of The Companions To Aisha, May Allah Be Pleased With Her, Sumaiah Saleh Al-Shaikh

UB Journal for Humanities

This study explores the ethical guidelines governing interactions between men and non-mahram women through the questions posed by the Companions to Aisha, May Allah be pleased with her. The study aims to examine the nature of these questions, which reveal the ethical parameters that guided these interactions, as well as to shed light on the environment in which these questions were asked, reflecting the Companions' commitment to ethical values in their conduct. The research employs a historical-descriptive methodology to analyze the context of the questions by tracking the words and actions of the Companions who sought guidance from Aisha, in …

Restricted Word Order In Languages Without Overt Case Marking: Evidence From Modern Dialects Of Arabic, Mustafa Ahmed Al-Humari

UB Journal for Humanities

The study examines the morphosyntactic strategies used in Arabic language to indicate grammatical functions (subject, object) within a sentence, comparing and contrasting modern dialects of Arabic, particularly Saudi Arabic, and Yemeni Arabic, with Standard Arabic. The empirical observation of the study is that, while Standard Arabic mainly relies on a case marking strategy to determine grammatical functions, the modern dialects of Arabic under investigation are incapable of employing this strategy. This incapability raises questions about how grammatical functions are indicated in the absence of overt case morphology in the mentioned dialects. The paper argues that the absence of overt case …

Ibn Hajar's Annotations In His Work "Al-Nukat On Ibn Al-Salah": A Case Study On The Hasan Hadith, Nadia Abdulrahman Abdullah Alasbali

UB Journal for Humanities

This study examines the concept of annotations and the related terminologies, with a focus on the importance of studying such annotations in the field of Hadith. The research highlights the contributions of the two eminent scholars, Ibn Al-Salah and Ibn Hajar, as well as the significance of their respective works. Particular attention is given to Ibn Hajar's critical annotations on Ibn Al-Salah's classification of "Hasan Hadith" (Good Hadith). The study adopts an inductive methodology, collecting and analyzing Ibn Hajar's critiques of other scholars. Key findings include the differences in terminological connotations between early and later scholars, as well as the …

Legal Controls / Regulations For Advertising Financial Products And Services Which Are Provided By The Financial Institutions, Essa Ali M Aseery

UB Journal for Humanities

Financial institutions offer multiple range of diverse services with the goal of supporting and advancing economic security, conducive to achieving benefits and profits given that hey use and utilize advertising and promotion as a means of delivering and communicating their services and products to individuals and society, to the effect that this necessitates their adherence to and compliance with legal systems and regulations related to advertising. Of importance, this requires the accuracy of the data and information it contains, the clarity and soundness of its language, the inclusion of all service and product data, the avoidance of misleading and deceptive …

The Syntax Of Verbless Sentences In Bisha Najdi Arabic, Aeshah Muqbil Saeed Almineeai

UB Journal for Humanities

This study investigates the syntactic structure of verbless sentences in Bisha Najdi Arabic (henceforth BNA). It explores the different types of BNA verbless constructions, i.e., verbless constructions with nominal predicate, adjectival predicates and adverbial predicate. It argues for the nonverbal predicate analysis, as proposed by Benmamoun (2000, 2008), and extends the analysis to BNA verbless constructions within Chomsky's (1995) Minimalist Framework. In addition, the study argues that hnaak in similar constructions is a verb-like element, and accordingly, a syntactic analysis is provided for both BNA affirmative and negative hnaak-constructions. By investigating the syntactic structure of BNA verbless sentences, the study …

The Relationship Between Emotional Intelligence And The Practices Of Servant Leadership In The Kingdom Of Saudi Arabia, Rajeh Bati Fahad Almasradi

UB Journal for Humanities

The current study aimed to identify the relationship between emotional intelligence and servant leadership practices among health sector employees in the Asir region in the Kingdom of Saudi Arabia. Emotional intelligence was studied as an independent variable and servant leadership as a dependent variable. This study also investigates the relationship between emotional intelligence and the four dimensions of servant leadership: (conceptual skills/empowerment, emotional processing and care for others, and community development. The descriptive analytical approach was used, and the questionnaire tool was applied to collect data from the study population. A random sample representative of the study population was selected. …

Variations In Politeness Strategies Among Native Speakers Of Najdi Arabic And American English In Social Communication: A Cross-Cultural Study, Aeshah Muqbil Saeed Almineeai, Asseel Ali Alshahrani

UB Journal for Humanities

Uncovering what constitutes polite language in each culture and how certain expressions deemed acceptable in one society might be inappropriate in the other is the focus of politeness. Therefore, this study investigates the variations in communication strategies among speakers of Najdi Arabic, as spoken in Bisha City, and speakers of American English. The study basically explores how individuals from these distinct linguistic backgrounds respond to five different social scenarios. The study used qualitative approach to detect the responses of 15 speakers—11 Saudi Arabian natives and 4 Americans on some situations. Findings show there are some similarities in what may be …

Exploring The Intricate Relationship Between Automation And Performance In The Saudi Public Sector., Saleh Hamed Alharbi

UB Journal for Humanities

Office automation immensely enhances the working environment. Widespread technological revolution shapes Human Resource Management (HRM) practice. The most important factor in decision-making is the information on which the decision is based. Detailed and accurate information prevents erroneous decisions. This study explores the impact of the automation of HR processes on organizational performance in the public sector. Three hundred and sixteen (316) employees from the University of Tabuk participated in the study. The study used smart Partial Least Squares–Structural Equation Model (smart PLS-SEM) to estimate the relationships between constructs. The results reveal that office automation has a direct impact on organizational …