Digital Commons Network^™

Shale Investment Dashboard In Ohio Q3 And Q4 2024, Andrew R. Thomas, Mark Henning

All Maxine Goodman Levin School of Urban Affairs Publications

This report presents findings from an investigation into shale-related investment in Ohio, looking at up, mid, and downstream activities. The investment estimates are for July through December of 2024. The report also includes an estimate of cumulative investment into shale in Ohio from 2012 through December 2024. Prior biannual investments are included in previously posted reports that are available from Cleveland State University.

Child Development: A Developmentally Appropriate Practices Approach, Second Edition, D.R. Meece

Open Textbooks

The book follows a topical approach and covers children from prenatal to late childhood/early adolescence. The book follows a Developmentally Appropriate Practices approach, emphasizing that development results from the interaction of age-related expectations, culture and context, and individual child characteristics. The text is written for education majors, as well as others who will work with children and families in a variety of fields, including psychology, social work, nursing, and others.

Maria Gaetana Agnesi And The Proto-Feminist Movement, Katherine D. Wahnsiedler

Honors College Theses

Maria Gaetana Agnesi, a mathematician and scholar from the 18 th century, is an important historical figure who received a position at the University of Bologna. She is the second woman ever to be appointed to a University professorship, laying the foundation for other women in academia later to come. Many historians interpret Agnesi’s life to be representative of early feminist ideas and would therefore be an example of a proto-feminist. However, this is not accurate, nor is it an ideology Agnesi likely would have subscribed to. Analyzing primary sources written by Agnesi and her contemporaries helps provide insight into …

Adaptive Deep Learning In Physical Layer Applications, Ali Owfi

All Dissertations

Traditionally, signal processing models in communication systems have been designed based on solid foundations in statistics and information theory, often assuming linearity and optimizing for simplified models. However, real-world communication systems exhibit numerous imperfections and non-linearities that traditional linear models struggle to capture accurately. Deep Learning (DL)-based approaches, unconstrained by rigid mathematical models, have shown promise in optimizing system performance by accommodating specific hardware configurations and dynamic channel conditions as an alternative to the traditional methods. Despite all the recent research efforts on DL-based methods for physical layer applications, DL models have still not been widely applied to physical layer …

Interview With Orca Award Winner Karen Kunc, Unl Art; Abstract Print Artist, Mark Griep, Karen Kunc

UNL ORCA Interview Series

Emeritus Prof. Karen Kunc the Outstanding Research and Creative Activities Award in 1998. She was born in Ralston, Nebraska, in the Omaha Metro Area. Something in her youth must have sparked an interest in art because she earned her bachelor of fine arts degree from the University of Nebraska-Lincoln in 1975. Next, she ventured 800 miles east to Ohio State University in Columbus, where she earned a master of fine arts. For the next six years, she enhanced her teaching credentials as a printmaking instructor at the Columbus College of Art & Design. From there, she joined the University of …

Self-Efficacy In Juvenile Probation Officers: An Examination Of Training, Eva K. Ott Hill

Master's Theses

The role of juvenile probation officers (JPO) has significantly changed in the past two decades. Rather than a focus on compliance, juvenile probation officers are tasked with using evidence-based practices focused on rehabilitation. Training is a key tool as it equips juvenile probation officers with the skills they need to implement new evidence-based practices and programs. Juvenile probation officers’ confidence in their ability to complete their changing job tasks should increase when they receive training. The current study examines how training impacts perceived self-efficacy among juvenile probation officers in Connecticut. The study seeks to understand what aspects of training impact …

Vol. 8, No. 2 Cover

Southern African Journal of Policy and Development

No abstract provided.

Beyond The Aid Paradigm: Neocolonialism, Recolonisation And The Future For Africa’S Development, John Ringson, Manamela Johannes David Matshabaphala

Southern African Journal of Policy and Development

The persistence of poverty, inequality, and underdevelopment in Africa, despite decades of foreign aid and assistance, has raised fundamental questions about the efficacy and sustainability of the aid paradigm. This qualitative desktop research study, employing discourse analysis, critically examines the complex relationships between aid, neocolonialism, and recolonisation in Africa, exploring the implications for the continent's future development. Drawing on a critical discourse analysis of existing literature, policy documents, and online archives, this study reveals how the aid paradigm has perpetuated neocolonialism and recolonisation in Africa, undermining the continent's sovereignty, agency, and self-determination. The study illuminates the power dynamics and relationships …

How Is South Africa's Black Economic Empowerment Policy (Bee) Addressing Historical Inequalities And Promoting Inclusive Development As Of 2024?, Nasim Uz Zaman

Southern African Journal of Policy and Development

South Africa’s Black Economic Empowerment (BEE) policy was introduced to dismantle apartheid-era economic disparities; however, its corporate-driven model has fostered symbolic compliance rather than substantive transformation. This study critically examines BEE’s structural limitations, specifically its failure to generate mass employment, its susceptibility to elite capture, and the prevalence of "fronting" practices. By juxtaposing BEE with affirmative action frameworks in Malaysia, India, and the United States, this research elucidates why ownership redistribution alone has failed to translate into inclusive economic mobility. Employing a qualitative policy analysis, this study synthesizes unemployment trajectories, implementation distortions, and systemic governance inefficiencies to highlight the constraints …

(R2125) Impact Of Convective Condition And Inclined Magnetic Field On Casson Nanofluid With Bioconvection In Porous Medium, Touseef Fayaz, O. Otegbeye, Md. Sharifuddin Ansari

Applications and Applied Mathematics: An International Journal (AAM)

This paper presents an analysis on steady magnetohydrodynamic boundary layer flow of Casson nanofluid with microorganisms near an expandable boundary in a porous medium. The flow behaviour is analysed by incorporating impacts of magnetic field applied in a direction which makes an angle α∗ with the boundary and convective conditions in temperature, nanoparticle concentration and microorganism density at boundary. Non-dimensionalised nonlinear and coupled system of ordinary differential equations are solved by exercising a numerical algorithm termed as spectral local-linearization method. The considered numerical algorithm is found to be convergent and capable of yielding accurate results. Graphical sketches of solutions obtained …

Habit Pals: A Habit Awareness App, Sophia R. Huber

Graphic Communication

Habit Pals is a gamified mobile app prototype that helps users reduce skin-picking and nail-biting through positive reinforcement, reflection, and taking care of a virtual pet. Informed by survey results and behavior change research, the design replaces pressure based streak systems with gentle encouragement, small rewards, and calming visuals. The prototype demonstrates how supportive, low pressure UX can promote self-awareness and healthier habits.

December 2025 Library & Learning Newsletter, Minnesota State University, Mankato. Library & Learning Dean’S Office Communications Team

Library & Learning Newsletters

PDF version of the December 2025 (Volume 4, Issue 5) Library & Learning Newsletter.

Chapter 6 Slides: Internship/Practicum/Capstone Project Requirements, Lisa Dunkley

Internship, Practicum, and Capstone: A Guide for Health Sciences

No abstract provided.

Applied Project Management Methodologies To Create A Volunteer Engagement Guide For New Hope Nonprofit Organization's Volunteer Program, Carlos San Miguel

Student Projects for Graduate Degrees

Nonprofit organizations (NPOs) rely on volunteers to sustain operations and fulfill their missions, yet many realize persistent challenges in recruiting, training, and keeping them. New Hope Compassionate Ministries (NHCM), a nonprofit organization in Alaska, has struggled to attract and keep volunteers for inventory and restock days—limitations that directly impact its ability to combat food insecurity. This project applies structured project management methodologies to find and address NHCM’s volunteer engagement gap. Through mixed-methods research, including surveys and interviews, the project analyzes current volunteer recruitment and retention practices to uncover underlying barriers. Findings inform the development of a Volunteer Engagement Guide designed …

Impact Of Antibody Fc Engineering On Translational Pharmacology, And Safety: Insights From Industry Case Studies., Frank R Brennan, J Ryan Polli, Jean Sathish, Melissa Ramones, Babette Wolf, Tilman Schlothauer, Shirley J Peters, Curtis C Maier, Changhua Ji, David L Wensel, Derrick Witcher, Patricia C Ryan, T Scott Manetz, Adriano Flora, Brian Soper, Birgit Fogal, Lindsey Dzielak, Xiaoting Wang, Prathap Nagaraja Shastri, Karen Price, Michael Doyle, Nidhi Sharda, Mary Struthers, Maximilian Brinkhaus, Bianca Balbino, Eric Stefanich, Masaki Honda, Jan Terje Andersen, Shermaine Mitchell-Ryan, David P Humphreys

Faculty Research 2025

Therapeutic monoclonal antibodies (mAbs) are often designed to not only bind targets via their antigen-binding domains (Fabs) but to also engage with cell surface receptors, FcγRs and FcRn, through their Fc regions, which may result in a variety of functional outcomes, including antibody- dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement-dependent cytotoxicity (CDC) and alteration of circulating half-lives. Engineering the Fc regions to achieve desirable pharmacology and pharmacokinetics is a widely adopted strategy in drug development. Fc regions can be modified through amino acid substitutions and glycoengineering, resulting in enhanced or reduced effector functions, preferential binding to FcR subtypes, …

Molecular Systems Biology At 20: Reflecting On The Past, Envisioning The Future., Poonam Bheda, Jingyi Hou, Ruedi Aebersold, Uri Alon, Joel S Bader, Lee Bardwell, Edison Liu, James C W Locke, Matthias Mann, Andrew J Millar, Felix Naef, Yitzhak Pilpel, Ron Shamir, Dennis Vitkup

Faculty Research 2025

As Molecular Systems Biology marks its 20th anniversary, we take this moment to reflect on two decades of discovery and innovation. Since its launch, the journal has stood at the forefront of integrating quantitative biology, computational modeling, and systems science—helping to shape how we understand complex biological systems.

Rna Binding Of Gapdh Controls Transcript Stability And Protein Translation In Acute Myeloid Leukemia., Sama Shamloo, Jeffrey L Schloßhauer, Shashank Tiwari, Kim Denise Fischer, Omar Almolla, Yohana Ghebrechristos, Lisa Kratzenberg, Aathma Merin Bejoy, Ioannis Aifantis, Francesco Boccalatte, Eric Wang, Jochen Imig

Faculty Research 2025

Dysregulation of RNA binding proteins (RBPs) is a hallmark in cancerous cells. In acute myeloid leukaemia (AML) RBPs are key regulators of tumour proliferation. While classical RBPs have defined RNA binding domains, RNA recognition and function in AML by non-canonical RBPs (ncRBPs) remain unclear. Given the inherent complexity of targeting AML broadly, our goal was to uncover potential ncRBP candidates critical for AML survival using a CRISPR/Cas-based screening. We identified the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a pro-proliferative factor in AML cells. Based on cross-linking and immunoprecipitation (CLIP), we are defining the global targetome, detecting novel RNA targets mainly …

Low-Coverage Whole-Genome Sequencing Facilitates Accurate And Cost-Effective Haplotype Reconstruction In Complex Mouse Crosses., Samuel J Widmayer, Lydia K Wooldridge, Emily Swanzey, Mary Barter, Chrystal M Snow, Michael C Saul, Qingchang Meng, Beth L Dumont, Laura G Reinholdt, Daniel M Gatti

Faculty Research 2025

The search for the underlying genetic contributions to complex traits and diseases relies on accurate genetic data from populations of interest. Outbred populations, like the Diversity Outbred (DO), are commonly genotyped using commercial SNP arrays, such as the Giga Mouse Universal Genotyping Array (GigaMUGA). However, array genotypes are expensive to collect, subject to significant ascertainment bias, and too sparse to capture the genetic structure of highly recombined mouse crosses. We investigated the efficacy of sequencing-based genotyping by comparing genotyping results between the GigaMUGA, double-digest restriction-site associated DNA sequencing (ddRADseq), and low-coverage whole-genome sequencing (lcWGS). We aligned reads at ~ 1× …

Harmonizing Mouse Anatomy Terminology: A Common Language?, Jesús Ruberte, Paul N Schofield, John P Sundberg, Sergi Olvera-Maneu, Ana Carretero

Faculty Research 2025

The mouse remains the principal animal model for investigating human diseases due, among other reasons, to its anatomical similarities to humans. Despite its widespread use, the assumption that mouse anatomy is a fully established field with standardized and universally accepted terminology is misleading. Many phenotypic anatomical annotations do not refer to the authority or origin of the terminology used, while others inappropriately adopt outdated or human-centric nomenclature. This inconsistency is further exacerbated by the limited availability of comprehensive anatomical references, often compelling researchers to rely on "do-it-yourself" anatomical interpretations when characterizing disease models-an approach that increases the risk of inaccuracies …

Single-Cell Landscape Of Sex-Specific Drivers Of Alzheimer's Disease., Yiyang Wu, Kyle J Travaglini, Mariano Gabitto, C Dirk Keene, Amy R Dunn, Catherine C Kaczorowski, Philip L De Jager, Vilas Menon, Julie A Schneider, David A Bennett, Logan Dumitrescu, Timothy J Hohman

Faculty Research 2025

INTRODUCTION: We investigated sex-specific gene expression associations with the neuropathology and cognitive manifestation of Alzheimer's disease (AD) leveraging single-nucleus transcriptomic datasets including 2.84 million nuclei from the dorsolateral prefrontal cortex (DLPFC).

METHODS: We delineated the full scope of sex-specific transcript associations, differential gene expression, signaling pathway, and cell-cell communication network changes in eight major DLPFC cell types.

RESULTS: Nine female-specific associations were identified and replicated, involving ADGRV1, OR3A3, IFI27L1, LYRM1, STAP2, TSTD2, PDYN, and TMEM50B. We observed the preponderance of protective female-specific associations in neurons. Sex-specific genes were enriched in the immune-, inflammation-, and damage-related stress-response pathways. Six ITGB1-mediated microglia-specific …

Pak1 Inhibitor Nvs-Pak1-1 Preserves Dendritic Spines In Amyloid/Tau Exposed Neurons And 5xfad Mice., Tao Yang, Hasi Huhe, Sean-Paul Williams, Sukhneet Kaur, Yeonglong Albert Ay, Zachary W Davis-Gilbert, Gregory Cary, Carolyn Paisie, Robert R Butler, Jesse Wiley, Ranjita Betarbet, Haian Fu, Duc Duong, Nicholas T Seyfried, Karina Leal, Gregory W. Carter, Aled Edwards, Allan I Levey, Jacob L Capener, David H Drewry, Mohammad A Hossain, Hans J Oh, Alison D Axtman, Stacey J Sukoff Rizzo, Frank M Longo, The Emory-Sage-Sgc-Jax Treat-Ad Center

Faculty Research 2025

INTRODUCTION: Synaptic spine loss in Alzheimer's disease (AD) contributes to cognitive decline. p21-activated kinase 1 (PAK1), a regulator of spine integrity, is aberrantly activated in AD. We investigated whether PAK1 inhibition might preserve dendritic spines in vitro and in vivo.

METHODS: Oligomeric amyloid beta (oAβ) or tau (oTau) were applied to hippocampal neurons ± NVS-PAK1-1, a selective PAK1 inhibitor. NVS-PAK1-1 was orally administered to 5xFAD mice. The effects of NVS-PAK1-1 treatment on PAK1 activity, spine density, and the proteome were assessed using phospho-PAK1 (pPAK1) western blotting, Golgi staining, and mass spectrometry for proteomic analyses.

RESULTS: NVS-PAK1-1 prevented oAβ and oTau-induced …

Integrated Phenotypic And Proteomic Screening Identifies Top-Tier Alzheimer's Disease Therapeutic Targets., Gregory Cary, Qianjin Li, Jesse C Wiley, Carolyn Paisie, Yuhong Du, Elizabeth L Zoeller, Duc Duong, Haian Fu, Nicholas T Seyfried, Allan I Levey, Ranjita Betarbet, Gregory W. Carter, The Emory-Sage-Sgc-Jax Treat-Ad Center

Faculty Research 2025

INTRODUCTION: Alzheimer's disease (AD) is a complex neurodegenerative disorder. Hundreds of therapeutic targets have been nominated through genetic and multi-omic studies, but effective prioritization remains a major bottleneck.

METHODS: We applied an integrative screening framework to assess 29 candidate targets from risk-enriched biological domains. Using disease-relevant murine BV2 microglial cell lines with stable Psen2 knockdown, we performed small interfering RNA-mediated perturbations followed by cellular phenotypic assays and quantitative proteomics.

RESULTS: Twenty-five candidate targets significantly altered at least one phenotype, with stronger effects in Psen2 knockdown cells. Integrated proteomic analyses identified several perturbations that reversed AD-associated molecular patterns. Five targets-Ap2a2, Pdhb, …

General Education Teachers' Perspectives And Practices For Supporting English Language Learners In Memphis Charter Schools, Ijiah Hargrove

Dissertations

The growing enrollment of English Language Learners (ELLs) in U.S. schools, particularly within urban charter settings, presents unique challenges for general education teachers who are often underprepared to meet both linguistic and academic needs. The purpose of this study was to explore the instructional strategies, perspectives of their ability of self-efficacy, and institutional factors that shape how K–8 charter school teachers in Memphis support ELLs. This work is significant because teachers’ beliefs, preparation, and available resources directly impact ELL achievement and equity in education.

A qualitative single-case study design was employed, with twelve general education teachers recruited through purposeful sampling. …

Sight-Singing Requirements Of Choral Festivals: A Fifty-State Comparison Of The Methods Used To Adjudicate Ensemble Literacy, William Griswold Jr

Dissertations

Standardized testing in the United States has permeated all levels of education including the choral music classroom. Across the country, state music organizations have implemented yearly evaluations of high school choral ensembles in which directors prepare choirs to be judged against a particular standard. While many organizations utilize similar methods of evaluating performances at adjudicated choral festivals, the methods used for evaluating sight-singing vary greatly from state to state. Throughout the country, various types of rhythmic, melodic, and harmonic exercises are used to evaluate an ensemble’s ability to sight-sing, however in certain states no form of sight-singing is required for …

Metabolically Guided Walking And Plant-Based Nutrition Enhance Body Composition And Weight Loss Dataset, Harold Mayer, Gregory Heath, Chris S. Hansen, Lucas G. Valenca, Kristina Nelson Hall, Cassie J. White

Datasets

Dataset for research published in International Journal of Environmental Research and Public Health.

Nymc Synapse Issue 56, School Of Medicine Student Senate, New York Medical College

The Synapse

No abstract provided.

Steel-Concrete Composite Girder Experiments To Isolate Interface Load Transfer Effects On Stud Fatigue Life, Marc Crespi Hromcova

Graduate Theses and Dissertations

Metal fatigue resulting from repeated loading is a primary limit state that affects the quantity of headed shear studs required in the composite design of steel bridge girders. While concrete-deck-to-steel-superstructure load transfer is only considered through stud bearing in the American Association of State Highway Transportation Officials (AASHTO) design standards, friction and interface interlocking effects may also contribute. This study aims to experimentally quantify the effect of interface conditions on the fatigue life of headed studs within composite girders. In this study, two full-scale composite girder specimens having the same geometry and material properties are tested with two interface conditions. …

A Journey And A Roadmap: Lessons Learned From Co-Creating An After-School Art Program With/For Newcomer Youth From Refugee Communities., Sally Anne Ball

Graduate Theses and Dissertations

This thesis focuses on my participation in a project developed in collaboration with a non-profit organization, Canopy NWA, with a goal to design and implement an after-school art program for newcomer youth from refugee communities that Canopy serves. This research inquiry is a self- study supported by observation, reflexive practice, and the use of a critical friend for mentorship, collaborative planning, group reflection, and co-developing and co-teaching curriculum. Through investigating my current teaching practices and my lack of experience teaching students from refugee communities, I set out to answer the following two questions: How will my art teaching practices develop, …

A Novel Maturation Equation For Hepatic Clearance Across Preterm, Term Neonates, Children, And Adults: Application To Paracetamol And Its Metabolite, Yunjiao Wu, Swantje Völler, Sebastiaan C. Goulooze, Karel Allegaert, Catherine M.T. Sherwin, Anne Van Rongen, Daniëlla W. E. Roofthooft, Sinno H.P. Simons, Dick Tibboel, Robert B. Flint, John N. Van Den Anker, Catherijne A.J. Knibbe

Pediatrics Faculty Publications

A preterm and term neonate to adult (PTNA) maturation equation was introduced recently to describe the glomerular filtration rate maturation from birth to adulthood for neonates of varying gestational age. This study aims to evaluate the newly developed PTNA equation against common maturation approaches like allometric scaling (AS0.75), the AS0.75 plus postmenstrual age (PMA)-based Emax (AS0.75 + PMA) equation, and the bodyweight dependent exponent equation (BDE) for the maturation of three hepatic pathways of paracetamol (PCM) from preterm and term neonates up to adults. A population pharmacokinetic analysis was conducted with pooled plasma and urine data of PCM, PCM-glucuronide (PCM-GLU), …

Teaching Note - Embedding The Human Library Experience Within Social Work Curriculum, Emily M. Paine

Social Work Faculty Works

The Human Library is a global initiative designed to challenge stereotypes and foster dialogue through storytelling and presents a unique opportunity for experiential learning within social work education. This teaching note explores how the Human Library framework can be integrated into social work curriculum in alignment with the 2022 Council on Social Work Education’s Educational Policy and Accreditation Standards, with particular emphasis on Competency 3: Engaging in Anti-Racism, Diversity, Equity, and Inclusion practice. When embedded in coursework, the Human Library enables students to engage in brave and authentic conversations with storytellers who share aspects of their lived experiences, promoting mutuality, …