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Developing A System Dynamics Framework For Sustained Digital Transformation, Quintal Battle Jan 2026

Developing A System Dynamics Framework For Sustained Digital Transformation, Quintal Battle

Graduate Studies Theses and Dissertations 2026

Despite significant organizational investments, more than 70% (Ellmer et al., 2025) of digital transformation initiatives fail. The existing literature evaluates transformation mechanisms as separate factors rather than as interacting, evolving feedback systems. This dissertation addresses this gap by developing and validating a system dynamics framework for sustained digital transformation. Guided by three research questions, the study examined the mechanisms that enable or constrain transformation, identified mechanisms distinctive to digital transformation contexts, and evaluated how existing change management frameworks guide transformation efforts. The study followed a six-phase methodology that combined a systematic literature review of peer-reviewed studies, empirical cases, causal loop …


Stolen Childhood: Picture Book Stories Of Indian Residential Schools, Maughn Rollins Gregory Jan 2026

Stolen Childhood: Picture Book Stories Of Indian Residential Schools, Maughn Rollins Gregory

Picture Books

In the nineteenth and twentieth centuries American and Canadian government agencies and Christian churches established Indian residential schools where hundreds of thousands of children were “reeducated” in English and Christianity. They were not allowed to use their native languages or given names, to practice their religions, or to communicate with their siblings or parents. They were made to work in crop fields, kitchens, laundries, and industrial workshops. Many were physically and sexually abused. Many never saw their families again. The nine picture books reviewed here are accounts of survivors of residential schools from eight different Indigenous nations. In addition to …


Shin-Chi’S Canoe (2008) By Nicola Campbell, Maughn Rollins Gregory Jan 2026

Shin-Chi’S Canoe (2008) By Nicola Campbell, Maughn Rollins Gregory

Picture Books

In the nineteenth and twentieth centuries American and Canadian government agencies and Christian churches established Indian residential schools where hundreds of thousands of children were “reeducated” in English and Christianity. They were not allowed to use their native languages or given names, to practice their religions, or to communicate with their siblings or parents. They were made to work in crop fields, kitchens, laundries, and industrial workshops. Many were physically and sexually abused. Many never saw their families again. The nine picture books reviewed here are accounts of survivors of residential schools from eight different Indigenous nations. In addition to …


The Effects Of Systematic Instructional Interventions On Functional Communication, Vocational Independence, And Academic Performance For High School Students With Autism In A Self-Contained Special Education Setting, Sarah O. Shalash Jan 2026

The Effects Of Systematic Instructional Interventions On Functional Communication, Vocational Independence, And Academic Performance For High School Students With Autism In A Self-Contained Special Education Setting, Sarah O. Shalash

University of Kentucky Master's Theses

This project evaluated the effects of systematic instruction on functional communication, vocational independence, and functional mathematics for three high school students with autism in a self-contained special education classroom using three A–B single-case designs. Interventions included a system of least prompts for AAC requesting and vocational task completion and constant time delay for a functional timer-setting task. Student performance was measured as the percentage of independently completed responses across instructional sessions. Student T demonstrated meaningful improvement in independent AAC requesting and reached 75% independence in the final session. Student B demonstrated emerging improvement in timer-setting performance and reached 60% independence …


17Β Estradiol Protection Against Medium-Change Neurotoxicity In Organotypic Hippocampal Slice Cultures, Autumn B. Stage Jan 2026

17Β Estradiol Protection Against Medium-Change Neurotoxicity In Organotypic Hippocampal Slice Cultures, Autumn B. Stage

University of Kentucky Master's Theses

Medium change neurotoxicity can disrupt glutamate homeostasis and promote excitotoxic neuronal injury through excessive NMDA receptor activation. 17β estradiol (E2) has demonstrated neuroprotective effects in models of neuronal injury and may regulate glutamatergic signaling through metabotropic glutamate receptors (mGluR2/3). This study investigated whether E2 protects against medium change associated neurotoxicity in organotypic hippocampal slice cultures whether responses differed by sex or hippocampal region. Hippocampal slices from postnatal day 8 male and female Sprague Dawley rats were maintained in culture and exposed to 1, 10, or 100 nM E2 for 24 hours following a five day recovery period. Propidium iodide (PI) …


Assessing Positive Digital Experiences: A Spanish Validation Of The Digital Flourishing Scale For Adolescents, Alfredo Zarco-Alpuente, Victor Ciudad Fernández, Jasmina Rosič, Sophie Janicke-Bowles, Tamara Escrivà-Martínez, Paula Samper-García Jan 2026

Assessing Positive Digital Experiences: A Spanish Validation Of The Digital Flourishing Scale For Adolescents, Alfredo Zarco-Alpuente, Victor Ciudad Fernández, Jasmina Rosič, Sophie Janicke-Bowles, Tamara Escrivà-Martínez, Paula Samper-García

Communication Faculty Articles and Research

Background: Adolescents are immersed in digital communication, which can benefit or harm their well-being. Digital flourishing captures positive perceptions of this communication-connectedness, authentic self-presentation, positive social comparison, civil participation, and self-control-and how it contributes to well-being. In Spain there is still no validated instrument for adolescents. Method: We adapted and validated the Digital Flourishing Scale for Adolescents (DFSA) for Spanish adolescents. Study 1 involved a pilot survey (n = 13) and cognitive interviews (n = 10) to improve clarity and cultural relevance. Study 2 used a cross-sectional survey (n = 1,786) to examine the DFSA’s latent structure, measurement invariance by …


The Career Choices Of Final Year Nursing Students In The United Kingdom: A Qualitative Study., Kevin Hambridge, Frazer Underwood, Gosia Bettache, Matt Carey, Halil Kaya, Lisa Burrows, Rachel Tims, Christian Brailsford Jan 2026

The Career Choices Of Final Year Nursing Students In The United Kingdom: A Qualitative Study., Kevin Hambridge, Frazer Underwood, Gosia Bettache, Matt Carey, Halil Kaya, Lisa Burrows, Rachel Tims, Christian Brailsford

School of Nursing and Midwifery

Aim: The aim of this study is to explore the career choices of final year under-graduate nursing students in the United Kingdom. Background: Worldwide there is a decreasing number of nurses and in the United Kingdom there is a decreasing amount of nursing students. There is sparce evidence relating to the career's choices of nursing students and reasons for those choices. Obtaining a deeper comprehension of these choices may aid healthcare employers, in partnership with universities, to design the future nursing workforce. Design: A qualitative design was used. Methods: Twenty-one final year under-graduate nursing students from across a range of …


What Is The Evidence For Effective Teaching Of Clinical Reasoning In Pre-Registration Dentistry?, Sally Hanks Jan 2026

What Is The Evidence For Effective Teaching Of Clinical Reasoning In Pre-Registration Dentistry?, Sally Hanks

Peninsula Dental School

A Commentary on: The impact of different teaching methods on clinical reasoning and clinical decision-making of dentistry students: a systematic review. Journal of Dental Education, 2026, 90(1), pp.33–42 Design: This systematic review examined evidence on educational interventions aimed at developing clinical reasoning and decision-making skills in undergraduate dental students. Searches of PubMed, MEDLINE (Ovid), Cochrane Library, and Scopus were conducted to 15 September 2023. Eighteen studies met the inclusion criteria for qualitative synthesis. Study designs included cross-sectional and case–control approaches. PRISMA guidance was followed, and a flow diagram was provided. Case selection: Eligible studies were English-language reports evaluating clinical reasoning …


Getting Ready Right: The Impact And Influence Of The University Appointed Supervisor, Madlen Griffiths Jan 2026

Getting Ready Right: The Impact And Influence Of The University Appointed Supervisor, Madlen Griffiths

Theses: Doctorates and Masters

Initial Teacher Education professional experience is a valued component of teacher education courses, where preservice teachers can practise applying what they have learned at university in classroom settings. Key to these experiences are supervisors, who are employed by the university and support these aspiring teachers during their professional experiences. This supervisory role is complex, underrated, under-theorised and under researched. Consequently, this research sought to address this shortfall through an investigation into the perspectives of two of the major stakeholders in these experiences: the preservice teachers and the supervisors.

Adopting a social constructivist methodology, this research examined the stakeholders’ perceptions of …


Development Of Virtual Reality Learning Environments In Science To Engage Secondary Students In Hazardous Activities, Luke Spartalis Jan 2026

Development Of Virtual Reality Learning Environments In Science To Engage Secondary Students In Hazardous Activities, Luke Spartalis

Theses: Doctorates and Masters

This research examines the need for change in including hazardous activities in education. As different learning technologies develop, platforms that retain authentic outcomes via virtual reality are needed. The main objective of this research is to examine the inclusion of Virtual Reality Learning Environments (VRLEs) to determine their value in areas that include hazardous conditions. The research considered the ways that VR tools could be optimised to support these activities, as well as considering the challenges of VRLE implementation. The study examined whether VRLE’s allowed for authentic experiences to sufficiently drive an acceptance of VR to complement existing teaching and …


Enhancing Deep Reinforcement Learning With Expert Demonstrations For Mobile Robot Navigation In Unstructured Off-Road Environments, Dulitha Dabare Jan 2026

Enhancing Deep Reinforcement Learning With Expert Demonstrations For Mobile Robot Navigation In Unstructured Off-Road Environments, Dulitha Dabare

Theses: Doctorates and Masters

Advancements in the field of Deep Learning has ushered in a boom in autonomous navigation research. Most of the work being conducted in this space, however, has focused on on-road urban navigation scenarios, with unstructured outdoor terrain navigation receiving much more limited attention. Given the wide range of applications that exist for legged and wheeled ground robots in off-road environments in areas such as agriculture, mining and disaster recovery, there is a growing need for research work to improve the navigational capabilities of mobile robots deployed in these challenging environments.

A promising candidate for application to these navigation challenges in …


Multimodal Scene Understanding For Mobile Robot Navigation In Unstructured Outdoor Environments, Liyana Mudiyanselage Nipuna Dinendra Wijayathunga Jan 2026

Multimodal Scene Understanding For Mobile Robot Navigation In Unstructured Outdoor Environments, Liyana Mudiyanselage Nipuna Dinendra Wijayathunga

Theses: Doctorates and Masters

The application of autonomous field robots in agriculture, mining, transport and logistics, disaster management, and exploration has increased with advances in sensing, perception, and autonomous navigation technologies. Western Australian off-road environments present challenges for autonomous ground robots because they contain unstructured ter rain, variations in appearance and geometry, changing illumination, and visually similar regions with different traversal characteristics. Reliable operation therefore requires scene understanding methods capable of representing the environment according to its navigability for robot traversal.

This PhD research investigates multimodal scene understanding for autonomous ground robot navigation in unstructured off-road environments. The research focuses on the development of …


Productivity Of An Iconic Waterbird, The Common Loon, Is Decreasing Across The Southern Portion Of Its Breeding Range, Matthew Fuirst, Mark L. Mallory, Walter H. Piper, Kristin Bianchini, Sethulakshmi Kumbalathuparambil Sajeev, Griffin Archambault, Dan Clark, John H. Cooley Jr., David C. Evers, Tiffany Grade, Eric W. Hanson, Caroline Hughes, Daniel Poleschook Jr., Virginia R. Poleschook, Lucas J. Savoy, Nina Schoch, Hillary Siener, Andrew Vitz, Harry S. Vogel, Jillian Whitney, Douglas C. Tozer Jan 2026

Productivity Of An Iconic Waterbird, The Common Loon, Is Decreasing Across The Southern Portion Of Its Breeding Range, Matthew Fuirst, Mark L. Mallory, Walter H. Piper, Kristin Bianchini, Sethulakshmi Kumbalathuparambil Sajeev, Griffin Archambault, Dan Clark, John H. Cooley Jr., David C. Evers, Tiffany Grade, Eric W. Hanson, Caroline Hughes, Daniel Poleschook Jr., Virginia R. Poleschook, Lucas J. Savoy, Nina Schoch, Hillary Siener, Andrew Vitz, Harry S. Vogel, Jillian Whitney, Douglas C. Tozer

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The Common Loon (Gavia immer) is an iconic waterbird of the northern wilderness and an indicator of the health of aquatic ecosystems. We conducted a benchmark comparison of productivity rates and long-term trends in productivity (6-week-old young raised per territorial pair) from 45 591 breeding events across 12 different study populations throughout the southern portion of species’ breeding range in North America. While all regions showed long-term mean productivity rates at or above the threshold considered necessary for population stability (0.48 chicks fledged per territorial pair), we found significant declines in productivity (ranging from −0.17% to −2.8% per year) in …


Experimental Investigation Into The Effects Of Air Staging On Fouling In A Fixed-Bed Biomass Combustor, Akram Elsebaie Jan 2026

Experimental Investigation Into The Effects Of Air Staging On Fouling In A Fixed-Bed Biomass Combustor, Akram Elsebaie

Theses: Doctorates and Masters

Biomass offers significant potential as a sustainable and renewable substitute for fossil fuels in energy generation, playing a critical role in the reduction of global warming. However, despite its environmental benefits, biomass combustion faces persistent operational challenges, particularly fouling, which reduces efficiency and increases maintenance costs. Although fouling mechanisms have been studied in various combustion systems, there is limited research which addresses its formation and behaviour in fixed-bed biomass combustors under different air staging conditions. This research investigates fouling behaviour in a counter-current combustor, focusing on the influence of design (secondary air location), operational (air staging flowrates between the primary …


Enhancing Offshore Wind Resource Assessment Through Neural Network-Based Hf Radar Data Analysis, Nikolas Martzikos, Matthew Craven, David Walker, Daniel Conley Jan 2026

Enhancing Offshore Wind Resource Assessment Through Neural Network-Based Hf Radar Data Analysis, Nikolas Martzikos, Matthew Craven, David Walker, Daniel Conley

School of Engineering, Computing and Mathematics

The increasing demand for offshore wind energy underscores the need for accurate wind speed estimation to support the design and operation of offshore wind farms. High-Frequency Radar (HFR), a widely used remote sensing technology in oceanographic research, offers promising potential for wind resource assessment, particularly in areas where conventional measurements are limited. This study explores the application of artificial neural networks (ANNs) for offshore wind speed prediction using HFR-derived data, addressing key challenges in model development and training. A key feature of this approach is the use of a decade-long dataset from the Celtic Sea, off the southwest UK coast, …


A Multiple Case Study Exploring The Lived Experiences Of Special Education Teachers Of Students With Intellectual Disabilities, Patrece A. Scott Jan 2026

A Multiple Case Study Exploring The Lived Experiences Of Special Education Teachers Of Students With Intellectual Disabilities, Patrece A. Scott

Doctor of Education Dissertations

Special educators, particularly the teachers of students with intellectual disabilities, remained an understudied group in research. The purpose of this phenomenological qualitative study was to examine how special educators navigated their lived experiences collaborating with three key stakeholder groups: parents, general education teachers, and administrators, particularly working with students with intellectual disabilities. Specifically, this study examined how special educators experienced collaboration with those stakeholder groups through the framework of McClelland's (1961) Theory of Needs. The study involved two semi-structured interviews with each of the 12 participants, all of whom were special educators at the middle or high school level. These …


(Reverse) Piercing The Trust Veil, Eric Kades Jan 2026

(Reverse) Piercing The Trust Veil, Eric Kades

Faculty Publications

Emergent doctrine deems trusts legal entities distinct from their trustees and beneficiaries. Venerable doctrine empowers creditors to "pierce the veil" separating entities' and their owners' property to avoid inequitable treatment. This article weaves together the new and old to craft a legal roadmap for reversing the ongoing race to the bottom among the states authorizing indefensible self-settled asset protection trusts (SSAPTs) designed solely for the purpose of swindling creditors. As a matter of both policy and doctrine, piercing (more precisely, reverse piercing) an entity's veil is ideally suited to empower the creditor of a SSAPT beneficiary to get paid from …


The Specter Of Jury Nullification, Anna Offit Jan 2026

The Specter Of Jury Nullification, Anna Offit

Faculty Publications

Attention to the trial of Luigi Mangione has renewed debate about nullification—the jury’s inviolate power to acquit a defendant contrary to the evidence presented. Jury nullification proponents hold that it is a mechanism of last resort for refusing to apply laws that conflict with the public conscience. Opponents, by contrast, argue that nullification undermines the law by diminishing its legitimacy. To prosecutors and defense attorneys, however, these arguments are immaterial: Jury nullification is part of the institutional landscape of the contemporary jury trial and thus must be treated as a potentiality—a feature of the agnostic, strategic, and ethical terrain of …


Spinning-Induced Exertional Rhabdomyolysis Without Acute Kidney Injury, Yolanda V. Gutierrez, Ronald Shaju, Alyssa L. Sepulveda, Joaquin Rivera, Aamir Ahmad Jan 2026

Spinning-Induced Exertional Rhabdomyolysis Without Acute Kidney Injury, Yolanda V. Gutierrez, Ronald Shaju, Alyssa L. Sepulveda, Joaquin Rivera, Aamir Ahmad

School of Medicine Publications

Rhabdomyolysis is a condition with a myriad of causes, including both traumatic and non-traumatic. Traumatic conditions are observed in crush injuries, compartment syndrome, and fractures, while non-traumatic rhabdomyolysis is commonly seen due to exertional heat stroke, extreme physical exercise, and dehydration. This case report explores two cases of extreme non-traumatic rhabdomyolysis caused by indoor cycling, also known as spinning. A common complication of severe rhabdomyolysis is acute kidney injury (AKI), which increases the risk of renal failure. Rapid interventions such as aggressive intravenous fluids are necessary to prevent kidney function loss. In this case report, two sisters, on two separate …


Associations Of Blood Pressure Level And Variability With Cortical Thickness: A Cross-Sectional Analysis From The Maracaibo Aging Study, Romeo De Leon, Shana Garza, Silvia Mejia-Arango, Kristina Vatcheva, Sokratis Charisis, Claudia L. Satizabal, Luis J. Mena, Joseph H. Lee, Joseph D. Terwilliger, Eron Manusov Jan 2026

Associations Of Blood Pressure Level And Variability With Cortical Thickness: A Cross-Sectional Analysis From The Maracaibo Aging Study, Romeo De Leon, Shana Garza, Silvia Mejia-Arango, Kristina Vatcheva, Sokratis Charisis, Claudia L. Satizabal, Luis J. Mena, Joseph H. Lee, Joseph D. Terwilliger, Eron Manusov

School of Medicine Publications

Background: Although high blood pressure (BP) level and variability are associated with Alzheimer's Disease (AD), their relationship with cortical thickness in brain regions that are associated with AD is unclear. Furthermore, the role of 24-hour BP has not been examined. We investigated the associations of office and ambulatory BP measures with cortical thickness in brain regions implicated in AD.

Methods: We performed a cross sectional analysis of 304 participants without dementia from a population-based study with office and 24-hour BP and magnetic resonance imaging (MRI) data. We considered cortical thickness values derived from 10 regions throughout the frontal, parietal, and …


A Position Statement On Endovascular Models And Effectiveness Metrics For Mechanical Thrombectomy Navigation, On Behalf Of The Stakeholder Taskforce For Artificial Intelligence-Assisted Robotic Thrombectomy (Start), Harry Robertshaw, Anna Barnes, Phil Blakelock, Raphael Blanc, Robert Crossley, Rebecca Fahrig, Ameer E. Hassan, Benjamin Jackson, Lennart Karstensen Jan 2026

A Position Statement On Endovascular Models And Effectiveness Metrics For Mechanical Thrombectomy Navigation, On Behalf Of The Stakeholder Taskforce For Artificial Intelligence-Assisted Robotic Thrombectomy (Start), Harry Robertshaw, Anna Barnes, Phil Blakelock, Raphael Blanc, Robert Crossley, Rebecca Fahrig, Ameer E. Hassan, Benjamin Jackson, Lennart Karstensen

School of Medicine Publications

Although we are making progress in overcoming infectious diseases and cancer, one of the major medical challenges of the mid-21st century will be the increasing prevalence of stroke. Occlusions in large vessels are especially debilitating, yet effective treatment—needed within hours to achieve best outcomes—remains limited because of geographic accessibility. One solution for improving timely access to mechanical thrombectomy in geographically diverse populations is the widespread deployment of robotic surgical systems. Artificial intelligence assistance may enable the safe and effective upskilling of operators in this emerging therapeutic delivery approach. Our aim was to establish consensus frameworks for developing and validating artificial …


Eeg And Imu Gait Signal Processing: A Comparative Assessment Of The "Reza" Exponential Filter And Classic Filters, Reza Pousti, Daniel M. Russell, Derek C. Monroe, Christopher K. Rhea Jan 2026

Eeg And Imu Gait Signal Processing: A Comparative Assessment Of The "Reza" Exponential Filter And Classic Filters, Reza Pousti, Daniel M. Russell, Derek C. Monroe, Christopher K. Rhea

Rehabilitation Sciences Faculty Publications

Noise degrades both EEG and gait signals, and classical IIR filters (Butterworth, Chebyshev, elliptic) involve trade-offs between passband flatness, ripple, and roll-off. This study compared a novel exponential "Reza" filter with these designs for neural and locomotor data. We analyzed an open-source mobile brain-body imaging dataset with EEG and gait data from 49 healthy adults (EEG: 256-channel, 512 Hz; IMUs: six APDM Opals, 128 Hz). EEG channels were grand-averaged and band-pass filtered at 0.5-50 Hz, while IMU axes were averaged and band-pass filtered at 0.5-5 Hz. The outcomes were signal-to-noise ratio SNR (dB) and band-integrated Welch PSD (EEG:0.5-50 Hz; IMU:0.5-5 …


Eeg Signatures Of Motor Development In Early Childhood: A Systematic Review, Sonia Khurana, Ashwini Kulkarni, Thomas C. Bulea, Hunter J. Bennett Jan 2026

Eeg Signatures Of Motor Development In Early Childhood: A Systematic Review, Sonia Khurana, Ashwini Kulkarni, Thomas C. Bulea, Hunter J. Bennett

Rehabilitation Sciences Faculty Publications

Background

Early identification of motor developmental disorders is limited due to lack of objective neural markers that characterize typical neurodevelopmental patterns. This systematic review interprets and synthesizes existing evidence to propose a framework of EEG signatures associated with motor development in children aged 0-5 years, which may help inform future benchmarks for early assessment and intervention.

Methods

Following PRISMA guidelines, we searched published and gray literature across five databases between 2000 and 2025 (registered protocol). Included studies examined EEG during task-based, resting-state, or sleep studies linked to motor milestones, task performance, or standardized motor assessments. Study quality was assessed using …


Guidelines For Standard Basic Notations In Applied Statistics, Abhaya Indrayan, Shivani Saini Ms Jan 2026

Guidelines For Standard Basic Notations In Applied Statistics, Abhaya Indrayan, Shivani Saini Ms

COBRA Preprint Series

Whereas some statistical notations are standard and uniformly used by different workers, many are not. Varying notations lead to confusion among the readers, particularly those engaged with applied statistics material, such as medical professionals. This communication proposes that all basic notations be standardized so that the same notations are consistently used by different authors, in different books, journals, and articles for the benefit of those who are not rigorously trained statisticians. Guidelines for such standard notations are also provided. The lead must be taken by statisticians.


Campbell At 30: A Retrospective Appreciation, Michael W. Carroll, Peter Jaszi Jan 2026

Campbell At 30: A Retrospective Appreciation, Michael W. Carroll, Peter Jaszi

Scholarly Articles in Law Reviews & Journals

This Article traces the intellectual history of copyright law’s fair use doctrine at the Supreme Court from its first encounter with fair use to its landmark decision slightly more than three decades ago in Campbell v. Acuff-Rose Music, Inc. Campbell provided courts with a coherent, user-centered theory for applying the four statutory fair use factors provided under 17 U.S.C. § 107, a standard the Court recently ratified in Google LLC v. Oracle Am., Inc. and Andy Warhol Foundation for the Visual Arts v. Goldsmith. As one of three related articles, this Article advances two principal claims to contribute to …


Lunch Shaming And The Right To Privacy, Ira P. Robbins Jan 2026

Lunch Shaming And The Right To Privacy, Ira P. Robbins

Scholarly Articles in Law Reviews & Journals

Lunch shaming is the practice of penalizing students who cannot afford to pay for their meals, resulting in them being denied food, served alternative meals, or publicly identified. The origins of lunch shaming can be traced to the financial pressures faced by school districts that struggle to balance tight budgets with the mandate to provide free or reduced-price meals to eligible students. Despite legislative efforts and advocacy campaigns aimed at mitigating the problems associated with lunch shaming, the practice persists, exacerbated by rising food costs and the expiration of pandemic-era food programs.

Many law journal and other articles have correctly …


Readability Of Online Patient Education Materials For Myopia Management, Monica Jong, Michelle Waugh, Pinar Ozmizrak, Ian Flitcroft Jan 2026

Readability Of Online Patient Education Materials For Myopia Management, Monica Jong, Michelle Waugh, Pinar Ozmizrak, Ian Flitcroft

Research Outputs: 2025-Present

Purpose: Patients are turning to the internet to access educational materials to help them make healthcare decisions, making readability an important factor. This cross-sectional study assessed the readability of online patient education materials for myopia management treatments that have regulatory approval. Methods: The top 10 Google search results from May 2024 for freely available online patient information on myopia management modalities and regulatory-approved products in Canada and Australia were analysed for readability. The modalities included orthokeratology, myopia control spectacle lenses, myopia control soft contact lenses and atropine. The products included MiYOSMART® [HOYA®], Stellest® [Essilor®], MyoCare® [ZEISS], MiSight® 1 day [CooperVision®], …


Are Ocular Markers Of Sun Exposure Associated With Skin Cancer? A Cross-Sectional Analysis Of The Busselton Healthy Ageing Study, Gareth Lingham, Vinay Kumar Nilagiri, Holly Brown, Chrianna Bharat, Samantha S.Y. Lee, Maria Franchina, Michael Hunter, Kevin Murray, David Alonso-Caneiro, Catherine M. Olsen, David C. Whiteman, David A. Mackey Jan 2026

Are Ocular Markers Of Sun Exposure Associated With Skin Cancer? A Cross-Sectional Analysis Of The Busselton Healthy Ageing Study, Gareth Lingham, Vinay Kumar Nilagiri, Holly Brown, Chrianna Bharat, Samantha S.Y. Lee, Maria Franchina, Michael Hunter, Kevin Murray, David Alonso-Caneiro, Catherine M. Olsen, David C. Whiteman, David A. Mackey

Research Outputs: 2025-Present

Background: Higher past sun or ultraviolet radiation exposure increases the risk of skin cancer and three common ocular findings: pterygium, conjunctival ultraviolet autofluorescence (CUVAF) and myopia. We investigated whether ocular markers of past sun exposure are associated with a history of skin cancer. Methods: A cross-sectional study of participants who attended the Phase 2 examination of the Busselton Healthy Ageing Study in Western Australia (2016–2022). Myopia was determined from autorefraction and pterygium and CUVAF from photographs of the anterior eye. Past diagnosis of a skin cancer was obtained from linked hospitalisation and cancer registry data (melanoma) or combining linked and …


Snif: Explainability-Driven Feature Selection Through State-Of-The-Art Shap–Nca Intersection Framework For Malware Detection, Sadia Nazim, Syed Shujaa Hussain, Bilal Yousuf, Jawahir Che Mustapha Jan 2026

Snif: Explainability-Driven Feature Selection Through State-Of-The-Art Shap–Nca Intersection Framework For Malware Detection, Sadia Nazim, Syed Shujaa Hussain, Bilal Yousuf, Jawahir Che Mustapha

Research Outputs: 2025-Present

Modern malware detection rely on Deep neural networks to achieve high detection performance by leveraging a large feature space. However, these models often suffer from high dimensionality, limited interpretability, and reduced reliability due to redundant features. As a result, they obscure the true contribution of features to the rationale for the prediction. To address these challenges, this study proposes an explainability-aware feature pruning technique to improve the performance and efficiency of deep neural networks. The key focus of this study is the development of the novel SHAP–NCA Intersection Framework (SNIF), which integrates explainability with feature selection for efficient and trustworthy …


From Platelets To Particles: Optimizing Extracellular Vesicle Isolation In A National Blood Centre, Y. Chintala, A. Waters, F. Mcgrath, A. Lorusso, C. Wynne, S. Meaney Jan 2026

From Platelets To Particles: Optimizing Extracellular Vesicle Isolation In A National Blood Centre, Y. Chintala, A. Waters, F. Mcgrath, A. Lorusso, C. Wynne, S. Meaney

Research Outputs: 2025-Present

Background and Objectives: Platelet-derived extracellular vesicles (PEVs) are submicron, membrane-bound particles released upon platelet activation, with a recognized role in haemostasis, inflammation and immunoregulation. PEVs remain insufficiently characterized in blood products. This study compared four isolation methods to evaluate their impact on PEV yield, purity and characteristics, aiming to identify a practical approach for transfusion service workflows. Materials and Methods: PEVs were isolated from expired single-donor aphaeresis platelet concentrates (n = 12) using methods based on different isolation principles: ultracentrifugation (UC), size exclusion chromatography (SEC), mixed size/charge separation (hybrid) and an affinity-based spin column method (affinity). Size, number and biochemical …